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Paeonia rockii has been a traditional medicinal material from time immemorial. It is an important plant resource of ethnic medicine and chinese herbal medicine. It has unique effects on heat and cool blood, promoting blood circulation and dispersing blood stasis, analgesia and promoting menstruational flow. It is also a first-class protected plant. With the increasing demand for the bark and roots of P. rockii in China's medicinal market, the continuous high-intensity and disorderly excavation has led to a sharp decline in wild resources. P. rockii is in imminent danger and needs to be saved and protected urgently. In this study, the distribution records of P. rockii in China, combined with environmental factors, are used to simulate the current potential distribution area of P. rockii through MaxEnt model. The environmental factors affecting the distribution of P. rockii are obtained by using the contribution rate of environmental factors and a jackknife test analysis, and the appropriate value of environmental factors is determined by using the response curve. The results show that the AUC value of test set data is 0.985 and that of training set data is 0.987. The prediction accuracy of the Maxent model is extremely high and the simulation effect is very good. At present, the high suitable areas of P. rockii are mainly distributed in the shape of cake in Southern Ningxia, southern Gansu and southern Shanxi, accounting for 15.58% of the total suitable areas. The most important environmental factor affecting the geographical distribution of P. rockii is the altitude; Under the future climate change scenario, the total suitable area of P. rockii shows a decreasing trend, among which the area of high suitable area shows an obvious decreasing trend, the mass center of high suitable area of P. rockii generally tends to migrate to the northwest, and the migration range is large under the scenario of high concentration emission. The research results can provide scientific data support for P. rockii to to cope with the changes in suitable areas caused by climate change and the establishment of effective protection, clarify the change and heterogeneity of P. rockii in different regions of China in the future, and clarify its ecological needs, which has certain practical significance. [ABSTRACT FROM AUTHOR]

Objective: We investigated the possible lobe-specific lymph node (LN) metastasis pattern of early-stage peripheral non-small cell lung cancers (NSCLC) and define the extent of lobe-specific LN dissection for them., Methods: We retrospectively collected clinical data of patients undergoing lobectomy or segmentectomy with systematic lymphadenectomy for clinical T1N0M0 peripheral NSCLC from January 2015 to December 2018. The LN metastasis pattern was analyzed by tumor lobe location., Results: A total of 590 patients were included for analysis. The mean number of total dissected LNs was 12.3 ± 5.8 and 8.2 ± 4.1 for total dissected mediastinal LNs. The rate of mediastinal LN metastasis was 9.5%. For cases of upper lobe tumor and lower lobe tumor, 8.8% and 6.0% of them respectively metastasized to the upper LN zone (P = 0.274). However, upper lobe tumors hardly metastasized to the subcarinal (0.3%) and lower (0.3%) LN zones while for lower lobe tumors, the rate of LN metastasis was 10.2% and 5.4% respectively (both P < 0.001). However, all cases (100%) metastasizing from lower lobes to the upper LN zone had a tumor size of 2-3 cm, whereas cases with a tumor size ≤ 2 cm had no metastasis (0%). None of the tumors in the right middle lobe metastasized to the lower LN zone (0%)., Conclusions: A lobe-specific LN metastasis pattern was observed in clinical stage IA peripheral NSCLC. For tumors in upper lobes (≤ 3 cm), there may be no need to dissect lower mediastinal LNs and for tumors in lower lobes (≤ 2 cm), dissecting upper mediastinal LNs may not be required.