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Bilateral acute depigmentation of the iris (BADI) and bilateral acute iris transillumination (BAIT) are relatively new clinical entities characterized by acute pigment dispersion from the iris stroma or iris pigment epithelium, respectively. While BADI presents with diffuse or geographic areas of iris stromal depigmentation without transillumination, BAIT cases typically develop diffuse iris transillumination and mydriatic atonic pupils. Prolonged pigment dispersion and ocular hypertension are more common in BAIT. Although the exact etiopathogenesis is still unknown, moxifloxacin toxicity appears to be a probable/likely cause. The underlying cause of BADI or BAIT in patients who were not exposed to fluoroquinolone antibiotics remains unexplained. Systemic viral infections, including coronavirus disease 2019, may be the triggering event in several cases. [ABSTRACT FROM AUTHOR]

Purpose: To evaluate the efficacy and safety of transscleral diode laser cyclophotocoagulation (TSDLC) in advanced glaucoma patients with hest-corrected visual acuity (BCVA) of 0.3 Snellen unit or better. Materials and Methods: Patients with BCVA of 0.3 Snellen unit or better who underwent TSDLC for uncontrolled intraocular pressure (IOP) and followed up regularly for at least 12 months were evaluated retrospectively. The primary end-point was the decrease of one or more Snellen lines in BCVA, secondary end-point was the IOP control with or without medications. Results: Thirty-six eyes of 36 patients were included and followed for a mean of24.1+26.4 months. The mean IOP was reduced from 28.3±6.0 mmHg at baseline to 14.4±5.0 mmHg (p<0.001). The average number of antiglaucoma medications was significantly reduced from 3.7±0.5 at baseline to 3.0±0.87 (p<0.05) at last follow-up. BCVAremained constant in 24 (66.7%) eyes, improved in 4 (11.1%), and deteriorated by one line or more in 8 (22.2%). The vision loss was attributed to TSDLC in only 3 patients who had cystoid macular edema, central retinal vein occlusion and post-laser hypotony. Conclusion: TSDLC is an effective, safe, and technically easy procedure for controlling the IOP in advanced glaucoma cases with good visual acuity. TSDLC may be considered both as primary treatment and as an alternative treatment after failed filtration procedures instead of invasive glaucoma surgeries. [ABSTRACT FROM AUTHOR]

Purpose: To develop an algorithm for the diagnosis of Behçet's disease (BD) uveitis based on ocular findings. Methods: Following an initial survey among uveitis experts, we collected multi-center retrospective data on 211 patients with BD uveitis and 207 patients with other uveitides, and identified ocular findings with a high diagnostic odds ratio (DOR). Subsequently, we collected multi-center prospective data on 127 patients with BD uveitis and 322 controls and developed a diagnostic algorithm using Classification and Regression Tree (CART) analysis and expert opinion. Results: We identified 10 items with DOR >5. The items that provided the highest accuracy in CART analysis included superficial retinal infiltrate, signs of occlusive retinal vasculitis, and diffuse retinal capillary leakage as well as the absence of granulomatous anterior uveitis or choroiditis in patients with vitritis. Conclusion: This study provides a diagnostic tree for BD uveitis that needs to be validated in future studies. [ABSTRACT FROM AUTHOR]