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Your search keyword '"Santos, Eduardo José Melo dos"' showing total 17 results
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17 results on '"Santos, Eduardo José Melo dos"'

1. Severe COVID-19 and long COVID are associated with high expression of STING, cGAS and IFN-α

Author

Queiroz, Maria Alice Freitas, primary, Brito, Wandrey Roberto dos Santos, additional, Pereira, Keise Adrielle Santos, additional, Pereira, Leonn Mendes Soares, additional, Amoras, Ednelza da Silva Graça, additional, Lima, Sandra Souza, additional, Santos, Erika Ferreira dos, additional, Costa, Flávia Póvoa da, additional, Sarges, Kevin Matheus Lima de, additional, Cantanhede, Marcos Henrique Damasceno, additional, Brito, Mioni Thieli Figueiredo Magalhães d, additional, Silva, Andréa Luciana Soares da, additional, Leite, Mauro de Meira, additional, Viana, Maria de Nazaré do Socorro de Almei, additional, Rodrigues, Fabíola Brasil Barbosa, additional, Silva, Rosilene da, additional, Viana, Giselle Maria Rachid, additional, Chaves, Tânia do Socorro Souza, additional, Veríssimo, Adriana de Oliveira Lameira, additional, Carvalho, Mayara da Silva, additional, Henriques, Daniele Freitas, additional, Silva, Carla Pinheiro da, additional, Nunes, Juliana Abreu Lima, additional, Costa, Iran Barros, additional, Cayres-Vallinoto, Izaura Maria Vieira, additional, Brasil-Costa, Igor, additional, Quaresma, Juarez Antônio Simões, additional, Falcão, Luiz Fábio Magno, additional, Santos, Eduardo José Melo dos, additional, and Vallinoto, Antonio Carlos Rosário, additional

Published
2024
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4. Association of the IFNG +874T/A Polymorphism with Symptomatic COVID-19 Susceptibility.

Author

Sarges, Kevin Matheus Lima de, Póvoa da Costa, Flávia, Santos, Erika Ferreira dos, Cantanhede, Marcos Henrique Damasceno, da Silva, Rosilene, Veríssimo, Adriana de Oliveira Lameira, Viana, Maria de Nazaré do Socorro de Almeida, Rodrigues, Fabíola Brasil Barbosa, Leite, Mauro de Meira, Torres, Maria Karoliny da Silva, Bentes da Silva, Christiane, Brito, Mioni Thieli Figueiredo Magalhães de, Silva, Andréa Luciana Soares da, Henriques, Daniele Freitas, Vallinoto, Izaura Maria Vieira Cayres, Viana, Giselle Maria Rachid, Queiroz, Maria Alice Freitas, Vallinoto, Antonio Carlos Rosário, and Santos, Eduardo José Melo dos

Subjects
TUMOR necrosis factors, CYTOKINE release syndrome, COVID-19, SINGLE nucleotide polymorphisms, INFLAMMATORY mediators
Abstract

Tumor necrosis factor (TNF) and interferon-gamma (IFNγ) are important inflammatory mediators in the development of cytokine storm syndrome (CSS). Single nucleotide polymorphisms (SNPs) regulate the expression of these cytokines, making host genetics a key factor in the prognosis of COVID-19. In this study, we investigated the associations of the TNF -308G/A and IFNG +874T/A polymorphisms with COVID-19. We analyzed the frequencies of the two polymorphisms in the control groups (CG: TNF -308G/A, n = 497; IFNG +874T/A, n = 397), a group of patients with COVID-19 (CoV, n = 222) and among the subgroups of patients with nonsevere (n = 150) and severe (n = 72) COVID-19. We found no significant difference between the genotypic and allelic frequencies of TNF -308G/A in the groups analyzed; however, both the frequencies of the high expression genotype (TT) (CoV: 13.51% vs. CG: 6.30%; p = 0.003) and the *T allele (CoV: 33.56% vs. CG: 24. 81%; p = 0.001) of the IFNG +874T/A polymorphism were higher in the COVID-19 group than in the control group, with no differences between the subgroups of patients with nonsevere and severe COVID-19. The *T allele of IFNG +874T/A (rs2430561) is associated with susceptibility to symptomatic COVID-19. These SNPs provided valuables clues about the potential mechanism involved in the susceptibility to developing symptomatic COVID-19. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Association of Polymorphisms of IL-6 Pathway Genes (IL6, IL6R and IL6ST) with COVID-19 Severity in an Amazonian Population

Author

Rodrigues, Fabíola Brasil Barbosa, primary, da Silva, Rosilene, additional, Santos, Erika Ferreira dos, additional, de Brito, Mioni Thieli Figueiredo Magalhães, additional, da Silva, Andréa Luciana Soares, additional, de Meira Leite, Mauro, additional, Póvoa da Costa, Flávia, additional, de Nazaré do Socorro de Almeida Viana, Maria, additional, de Sarges, Kevin Matheus Lima, additional, Cantanhede, Marcos Henrique Damasceno, additional, Veríssimo, Adriana de Oliveira Lameira, additional, Carvalho, Mayara da Silva, additional, Henriques, Daniele Freitas, additional, Silva, Carla Pinheiro da, additional, Costa, Igor Brasil, additional, Nunes, Juliana Abreu Lima, additional, Costa, Iran Barros, additional, Viana, Giselle Maria Rachid, additional, Queiroz, Maria Alice Freitas, additional, Lima, Sandra Souza, additional, Lopes, Jeferson da Costa, additional, Torres, Maria Karoliny da Silva, additional, Vallinoto, Izaura Maria Vieira Cayres, additional, Bichara, Carlos David Araújo, additional, Vallinoto, Antonio Carlos Rosário, additional, and Santos, Eduardo José Melo dos, additional

Published
2023
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7. Imbalance of Peripheral Temperature, Sympathovagal, and Cytokine Profile in Long COVID

Author

Neves, Pablo Fabiano Moura das, primary, Quaresma, Juarez Antônio Simões, additional, Queiroz, Maria Alice Freitas, additional, Silva, Camilla Costa, additional, Maia, Enzo Varela, additional, Oliveira, João Sergio de Sousa, additional, Neves, Carla Manuela Almeida das, additional, Mendonça, Suellen da Silva, additional, Falcão, Aline Semblano Carreira, additional, Melo, Giovana Salomão, additional, Santos, Isabella Boechat Faria, additional, Sousa, Jorge Rodrigues de, additional, Santos, Eduardo José Melo dos, additional, Vasconcelos, Pedro Fernando da Costa, additional, Vallinoto, Antonio Carlos Rosário, additional, and Falcão, Luiz Fábio Magno, additional

Published
2023
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8. Polymorphisms in the MBL2 gene are associated with the plasma levels of MBL and the cytokines IL-6 and TNF-α in severe COVID-19

Author

Queiroz, Maria Alice Freitas, primary, Santiago, Angélica Menezes, additional, Brito, Wandrey Roberto dos Santos, additional, Pereira, Keise Adrielle Santos, additional, de Brito, William Botelho, additional, Torres, Maria Karoliny da Silva, additional, Lopes, Jeferson da Costa, additional, Santos, Erika Ferreira dos, additional, da Costa, Flávia Póvoa, additional, de Sarges, Kevin Matheus Lima, additional, Cantanhede, Marcos Henrique Damasceno, additional, de Brito, Mioni Thieli Figueiredo Magalhães, additional, da Silva, Andréa Luciana Soares, additional, Leite, Mauro de Meira, additional, Viana, Maria de Nazaré do Socorro de Almeida, additional, Rodrigues, Fabíola Brasil Barbosa, additional, da Silva, Rosilene, additional, Viana, Giselle Maria Rachid, additional, Chaves, Tânia do Socorro Souza, additional, Veríssimo, Adriana de Oliveira Lameira, additional, Carvalho, Mayara da Silva, additional, Henriques, Daniele Freitas, additional, Santos, Carla Pinheiro dos, additional, Nunes, Juliana Abreu Lima, additional, Costa, Iran Barros, additional, Amoras, Ednelza da Silva Graça, additional, Lima, Sandra Souza, additional, Cayres-Vallinoto, Izaura Maria Vieira, additional, Brasil-Costa, Igor, additional, Quaresma, Juarez Antônio Simões, additional, Falcão, Luiz Fábio Magno, additional, Santos, Eduardo José Melo dos, additional, and Vallinoto, Antonio Carlos Rosário, additional

Published
2023
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9. Antibody Response to the SARS-CoV-2 Spike and Nucleocapsid Proteins in Patients with Different COVID-19 Clinical Profiles

Author

Soares, Sinei Ramos, primary, da Silva Torres, Maria Karoliny, additional, Lima, Sandra Souza, additional, de Sarges, Kevin Matheus Lima, additional, Santos, Erika Ferreira dos, additional, de Brito, Mioni Thieli Figueiredo Magalhães, additional, da Silva, Andréa Luciana Soares, additional, de Meira Leite, Mauro, additional, da Costa, Flávia Póvoa, additional, Cantanhede, Marcos Henrique Damasceno, additional, da Silva, Rosilene, additional, de Oliveira Lameira Veríssimo, Adriana, additional, Vallinoto, Izaura Maria Vieira Cayres, additional, Feitosa, Rosimar Neris Martins, additional, Quaresma, Juarez Antônio Simões, additional, Chaves, Tânia do Socorro Souza, additional, Viana, Giselle Maria Rachid, additional, Falcão, Luiz Fábio Magno, additional, Santos, Eduardo José Melo dos, additional, Vallinoto, Antonio Carlos Rosário, additional, and da Silva, Andréa Nazaré Monteiro Rangel, additional

Published
2023
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10. Cytokine Profiles Associated With Acute COVID-19 and Long COVID-19 Syndrome

Author

Queiroz, Maria Alice Freitas, primary, Neves, Pablo Fabiano Moura das, additional, Lima, Sandra Souza, additional, Lopes, Jeferson da Costa, additional, Torres, Maria Karoliny da Silva, additional, Vallinoto, Izaura Maria Vieira Cayres, additional, Bichara, Carlos David Araújo, additional, Santos, Erika Ferreira dos, additional, de Brito, Mioni Thieli Figueiredo Magalhães, additional, da Silva, Andréa Luciana Soares, additional, Leite, Mauro de Meira, additional, da Costa, Flávia Póvoa, additional, Viana, Maria de Nazaré do Socorro de Almeida, additional, Rodrigues, Fabíola Brasil Barbosa, additional, de Sarges, Kevin Matheus Lima, additional, Cantanhede, Marcos Henrique Damasceno, additional, da Silva, Rosilene, additional, Bichara, Clea Nazaré Carneiro, additional, Berg, Ana Virgínia Soares van den, additional, Veríssimo, Adriana de Oliveira Lameira, additional, Carvalho, Mayara da Silva, additional, Henriques, Daniele Freitas, additional, Santos, Carla Pinheiro dos, additional, Nunes, Juliana Abreu Lima, additional, Costa, Iran Barros, additional, Viana, Giselle Maria Rachid, additional, Carneiro, Francisca Regina Oliveira, additional, Palacios, Vera Regina da Cunha Menezes, additional, Quaresma, Juarez Antonio Simões, additional, Brasil-Costa, Igor, additional, Santos, Eduardo José Melo dos, additional, Falcão, Luiz Fábio Magno, additional, and Vallinoto, Antonio Carlos Rosário, additional

Published
2022
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11. Prevalence and Risk Factors for HTLV-1/2 Infection in Quilombo Remnant Communities Living in the Brazilian Amazon

Author

Brito, Wandrey Roberto dos Santos, primary, Cardoso-Costa, Greice de Lemos, additional, Roland Junior, Lourival Marques, additional, Pereira, Keise Adrielle Santos, additional, Lopes, Felipe Teixeira, additional, Santos, Bernardo Cintra dos, additional, de Lima, Aline Cecy Rocha, additional, Abreu, Isabella Nogueira, additional, Lima, Carlos Neandro Cordeiro, additional, Lima, Sandra Souza, additional, Cayres Vallinoto, Izaura M. Vieira, additional, Santos, Eduardo José Melo dos, additional, Guerreiro, João Farias, additional, and Vallinoto, Antonio Carlos Rosário, additional

Published
2022
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12. HLA-B*13, B*35 and B*39 Alleles Are Closely Associated With the Lack of Response to ART in HIV Infection: A Cohort Study in a Population of Northern Brazil

Author

Pereira, Leonn Mendes Soares, primary, França, Eliane dos Santos, additional, Costa, Iran Barros, additional, Jorge, Erika Vanessa Oliveira, additional, Mattos, Patrícia Jeanne de Souza Mendonça, additional, Freire, Amaury Bentes Cunha, additional, Ramos, Francisco Lúzio de Paula, additional, Monteiro, Talita Antonia Furtado, additional, Macedo, Olinda, additional, Sousa, Rita Catarina Medeiros, additional, Santos, Eduardo José Melo dos, additional, Freitas, Felipe Bonfim, additional, Costa, Igor Brasil, additional, and Vallinoto, Antonio Carlos Rosário, additional

Published
2022
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14. Standardization of a Polymerase Chain Reaction Protocol for Detecting Antimicrobial Peptides in Anopheles Darlingi (Diptera: Culicidae) Mosquitoes from the Brazilian Amazon

Author

Santos, Erian, primary, Santos, Ana Cecília Feio dos, additional, Pires, Luciana Letícia da Costa, additional, Casseb, Samir Mansour Moraes, additional, Holanda, Gustavo Moraes, additional, Sucupira, Izis Mônica Carvalho, additional, Cruz, Ana Cecília Ribeiro, additional, Santos, Eduardo José Melo dos, additional, and Póvoa, Marinete Marins, additional

Published
2021
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17. A influência dos polimorfismos nos genes interferons lambda 3 lambda 4 e ancestralidade genética na infecção crônica pelo vírus da hepatite c e na resposta ao tratamento em uma população miscigenada de Belém-Pará-Brasil

Author

AMARAL, Ivanete do Socorro Abraçado, QUARESMA, Juarez Antônio Simões, and SANTOS, Eduardo José Melo dos

Subjects
Herança genética, Hepatite C, CIENCIAS BIOLOGICAS::GENETICA::GENETICA HUMANA E MEDICA [CNPQ], Pará - Estado, Belém - PA, Doença infectocontagiosa
Abstract

A infecção crônica pelo vírus da Hepatite C é um problema global de saúde pública em que mais da metade dos indivíduos infectados evoluem para a sua forma crônica bem como carcinoma hepatocelular. Este estudo objetiva descrever os polimorfismos nos genes da IL-28B e do IFNL4 na população de Belém com infecção crônica pelo vírus da hepatite C já que podem influenciar na resposta terapêutica e na história natural desta infecção. Trezentos e sessenta e seis pacientes foram atendidos no Hospital da Santa Casa de Misericórdia do Pará confirmados por RT-PCR e 243 controles. Os SNPS estudados foram determinados por técnica da PCR Real time e a ancestralidade foi avaliada usando 48 marcadores INDEL validados para populações parentais Europeu, Africano e Indígena. Foi encontrado contribuições de ancestraliade Africana, Europeia e Ameríndia em pacientes e controles, respectivamente (0,06 vs 0,04), (0,588vs 0,662), (0,275) vs (0,214). As frequências dos rs-860 C/C, C/T, T/T, (C/T e T/T) em pacientes e em controles, respectivamente foram: (21% vs 38%), (59% vs 48%), (19% vs 14%), (79% vs 62%). As frequências genotípicas nos rs-917 em pacientes e em controles não mostraram significância. As distribuições das frequências genotípicas no ss-590 foram semelhantes às encontradas no rs-860. Como preditores de resposta terapêutica: gênero feminino, idade abaixo de 45 anos, estágio de fibrose hepática F1F2, rs8099917 genótipo T/T, RNA HCV

Published
2015

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