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Your search keyword '"Schulkey, Claire E"' showing total 7 results
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7 results on '"Schulkey, Claire E"'

1. Prevalence of 12 Common Health Conditions in Sexual and Gender Minority Participants in the All of Us Research Program

Author

Tran, Nguyen K., primary, Lunn, Mitchell R., additional, Schulkey, Claire E., additional, Tesfaye, Samantha, additional, Nambiar, Siddhartha, additional, Chatterjee, Snigdhansu, additional, Kozlowski, Dawn, additional, Lozano, Paula, additional, Randal, Fornessa T., additional, Mo, Yicklun, additional, Qi, Siya, additional, Hundertmark, Ell, additional, Eastburn, Chloe, additional, Pho, Anthony T., additional, Dastur, Zubin, additional, Lubensky, Micah E., additional, Flentje, Annesa, additional, and Obedin-Maliver, Juno, additional

Published
2023
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2. NIH funding longevity by gender

Author

Hechtman, Lisa A., Moore, Nathan P., Schulkey, Claire E., Miklos, Andrew C., Calcagno, Anna Maria, Aragon, Richard, and Greenberg, Judith H.

Published
2018

3. Design and Implementation of the All of Us Research Program COVID-19 Participant Experience (COPE) Survey

Author

Schulkey, Claire E, primary, Litwin, Tamara R, additional, Ellsworth, Genevieve, additional, Sansbury, Heather, additional, Ahmedani, Brian K, additional, Choi, Karmel W, additional, Cronin, Robert, additional, Kloth, Yasmin, additional, Ashbeck, Alan W, additional, Sutherland, Scott, additional, Mapes, Brandy, additional, Begale, Mark, additional, Bhat, Geeta, additional, King, Paula, additional, Marginean, Kayla, additional, Wolfe, Keri Ann, additional, Kouame, Aymone, additional, Raquel, Carmina, additional, Ratsimbazafy, Francis, additional, Bornemeier, Zach, additional, Neumeier, Kyle, additional, Baskir, Rubin, additional, Gebo, Kelly A, additional, Denny, Joshua, additional, Smoller, Jordan W, additional, and Garriock, Holly A, additional

Published
2023
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4. The maternal-age-associated risk of congenital heart disease is modifiable

Author

Schulkey, Claire E., Regmi, Suk D., Magnan, Rachel A., Danzo, Megan T., Luther, Herman, Hutchinson, Alayna K., Panzer, Adam A., Grady, Mary M., Wilson, David B., and Jay, Patrick Y.

Subjects
Congenital heart disease -- Risk factors -- Genetic aspects, Age -- Health aspects, Mother and child -- Health aspects, Pregnant women -- Health aspects -- Genetic aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Maternal age is a risk factor for congenital heart disease even in the absence of any chromosomal abnormality in the newborn (1-7). Whether the basis of this risk resides with the mother or oocyte is unknown. The impact of maternal age on congenital heart disease can be modelled in mouse pups that harbour a mutation of the cardiac transcription factor gene Nkx2-5 (ref. 8). Here, reciprocal ovarian transplants between young and old mothers establish a maternal basis for the age-associated risk in mice. A high-fatdiet does not accelerate the effect of maternal ageing, so hyperglycaemia and obesity do not simply explain the mechanism. The age-associated risk varies with the mother's strain background, making it a quantitative genetic trait. Most remarkably, voluntary exercise, whether begun by mothers at a young age or later in life, can mitigate the risk when they are older. Thus, even when the offspring carry a causal mutation, an intervention aimed at the mother can meaningfully reduce their risk of congenital heart disease., Congenital heart disease remains a leading cause of childhood morbidity and mortality despite dramatic clinical advances. Discoveries regarding the pathogenic mechanisms have likewise abounded, but translating knowledge about the causes [...]

Published
2015

7. Nkx2-5 and Sarcospan genetically interact in the development of the muscular ventricular septum of the heart

Author

Panzer, Adam A., primary, Regmi, Suk D., additional, Cormier, DePorres, additional, Danzo, Megan T., additional, Chen, Iuan-bor D., additional, Winston, Julia B., additional, Hutchinson, Alayna K., additional, Salm, Diana, additional, Schulkey, Claire E., additional, Cochran, Rebecca S., additional, Wilson, David B., additional, and Jay, Patrick Y., additional

Published
2017
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