Search

The quality assurance system of postgraduate training is a powerful guarantee to ensure the quality of postgraduate training. By combing the literature research on the quality assurance system of postgraduate training in military academies, this paper finds three types and seven specific problems that affect the quality of training. In view of the current training characteristics, the prospect of quality improvement is put forward from three aspects : theoretical research, training status and system construction. The research results provide a theoretical basis for the construction of a quality assurance system for postgraduate training in military academies in the context of the new era.

Ovarian cancer is among the most common gynecological cancers and the eighth leading cause of cancer‐related deaths among women worldwide. Surgery is among the most important options for cancer treatment. During surgery, a biopsy is generally required to screen for lesions; however, traditional case examinations are time consuming and laborious and require extensive experience and knowledge from pathologists. Therefore, this study proposes a simple, fast, and label‐free ovarian cancer diagnosis method that combines second harmonic generation (SHG) imaging and deep learning. Unstained fresh human ovarian tissues were subjected to SHG imaging and accurately characterized using the Pyramid Vision Transformer V2 (PVTv2) model. The results showed that the SHG imaged collagen fibers could quantify ovarian cancer. In addition, the PVTv2 model could accurately differentiate the 3240 SHG images obtained from our imaging collection into benign, normal, and malignant images, with a final accuracy of 98.4%. These results demonstrate the great potential of SHG imaging techniques combined with deep learning models for diagnosing the diseased ovarian tissues. [ABSTRACT FROM AUTHOR]

Global navigation satellite system (GNSS) provides users with all-weather, continuous, high-precision positioning, navigation, and timing (PNT) services. In the operation and use of GNSS, the influence of the space environment is a factor that must be considered. For example, during geomagnetic storms, a series of changes in the Earth's magnetosphere, ionosphere, and upper atmosphere affect GNSS's positioning performance. To investigate the positioning performance of global satellite navigation systems during geomagnetic storms, this study selected three geomagnetic storm events that occurred from September to December 2023. Utilizing the global positioning system (GPS)/Beidou navigation satellite system (BDS) dual-system, kinematic precise point positioning (PPP) experiments were conducted, and the raw observational data from 100 stations worldwide was analyzed. The experimental results show that the positioning accuracy of some stations in high-latitude areas decreases significantly when using the conventional Geometry Free (GF) cycle-slip detection threshold during geomagnetic storms, which means that the GF is no longer applicable to high-precision positioning services. Meanwhile, there is no significant change in the satellite signal strengths received at the stations during the period of the decrease in positioning accuracy. Analyzing the cycle-slip rates for stations where abnormal accuracy occurred, it was observed that stations experiencing a significant decline in positioning accuracy exhibited serious cycle-slip misjudgments. To improve the kinematic PPP accuracy during magnetic storms, this paper proposes an adaptive threshold for cycle-slip detection and designs five experimental strategies. After using the GF adaptive threshold, the station positioning accuracy improved significantly. It achieved the accuracy level of the quiet period, while the cycle-slip incidence reached the average level. During magnetic storms, the ionosphere changes rapidly, and the use of the traditional GF constant threshold will cause serious cycle-slip misjudgments, which makes the dynamic accuracy in high latitude areas and some mid-latitude areas uncommon, while the use of the GF adaptive threshold can alleviate this phenomenon and improve the positioning accuracy in the high-latitude regions and some of the affected mid-latitude areas during the magnetic storms. [ABSTRACT FROM AUTHOR]

To address the problem of low accuracy of construction schedule prediction in location-based management systems (LBMS), this paper adopts Harmony Search Algorithm (HS) to optimize the weights and thresholds of BP neural networks. By integrating practical construction information, an LBMS framework based on HS-BP neural networks is constructed to accurately predict the construction schedule. Finally, the prediction accuracy of HS-BP neural network is verified by taking the construction schedule of roof slab formwork of Guangzhou Guanglianda South China Headquarters Base Project as an example. The flow line of the actual and predicted schedules of the beam slab are also drawn to illustrate the reliability of the LBMS framework based on HS-BP neural network. [ABSTRACT FROM AUTHOR]

Differential code bias (DCB) of satellite is an error that cannot be ignored in precise positioning, timing, ionospheric modeling, satellite clock correction, and ambiguity resolution. The completion of the third generation of BeiDou Navigation Satellite System (BDS-3) has extended DCB to multichannel code bias observations and observable-specific signal bias (OSB). In this paper, the DCB and OSB products provided by the Chinese Academy of Sciences (CAS) are analyzed and compared. The DCB parameters for the BDS satellites are applied in both single- and dual-frequency single point positioning (SPP), and the results are intensively investigated. Based on the satellite DCB parameters of the BDS, the performance of precise point positioning (PPP) with different frequency combinations is also analyzed in terms of positioning accuracy and convergence time. The standard deviations (STDs) of DCBs at each signal pair fluctuate from 0.2 ns to 1.5 ns. The DCBs of BDS-2 are slightly more stable than those of BDS-3. The mean values and STDs of C2I and C7I OSBs for BDS-2 are at the same level and are numerically smaller than their counterparts for the C6I OSBs. The mean OSBs for each signal of the BDS-3, excluding C2I, fluctuate between 12.35 ns and 12.94 ns, and the STD fluctuates between 2.11 ns and 3.10 ns. The DCBs and OSBs of the BDS-3 of the IGSO satellites are more stable than those of the MEO satellites. The corrections for TGD and DCB are able to improve the accuracy of single-frequency SPP by 44.09% and 44.07%, respectively, and improve the accuracy of dual-frequency SPP by 6.44% and 12.85%, respectively. The most significant improvements from DCB correction are seen in single-frequency positioning with B1I and dual-frequency positioning with B2a+B3I. DCB correction can improve the horizontal and three-dimensional positioning accuracy of the dual-frequency PPP of different ionosphere-free combinations by 13.53% and 13.84% on average, respectively, although the convergence is slowed. [ABSTRACT FROM AUTHOR]

Summary: Background: Liver fibrosis is the strongest histological risk factor for liver‐related complications and mortality in metabolic dysfunction‐associated fatty liver disease (MAFLD). Second harmonic generation/two‐photon excitation fluorescence (SHG/TPEF) is a powerful tool for label‐free two‐dimensional and three‐dimensional tissue visualisation that shows promise in liver fibrosis assessment. Aim: To investigate combining multi‐photon microscopy (MPM) and deep learning techniques to develop and validate a new automated quantitative histological classification tool, named AutoFibroNet (Automated Liver Fibrosis Grading Network), for accurately staging liver fibrosis in MAFLD. Methods: AutoFibroNet was developed in a training cohort that consisted of 203 Chinese adults with biopsy‐confirmed MAFLD. Three deep learning models (VGG16, ResNet34, and MobileNet V3) were used to train pre‐processed images and test data sets. Multi‐layer perceptrons were used to fuse data (deep learning features, clinical features, and manual features) to build a joint model. This model was then validated in two further independent cohorts. Results: AutoFibroNet showed good discrimination in the training set. For F0, F1, F2 and F3‐4 fibrosis stages, the area under the receiver operating characteristic curves (AUROC) of AutoFibroNet were 1.00, 0.99, 0.98 and 0.98. The AUROCs of F0, F1, F2 and F3‐4 fibrosis stages for AutoFibroNet in the two validation cohorts were 0.99, 0.83, 0.80 and 0.90 and 1.00, 0.83, 0.80 and 0.94, respectively, showing a good discriminatory ability in different cohorts. Conclusion: AutoFibroNet is an automated quantitative tool that accurately identifies histological stages of liver fibrosis in Chinese individuals with MAFLD. [ABSTRACT FROM AUTHOR]

This study presents auxiliary support techniques for tree selection strategies based on the spatial structure indices and three competition indices in secondary forests, and discusses the importance of tree competition in forest management. The spatial structure parameter in the structured management is used as a quantitative index—the uniform angle index and three competition indices are used in the design of the algorithm for selective thinning for secondary forest. Based on the target tree-based management principles, simulation of selective thinning was carried out using GIS and C# programming languages. Data for this study were collected from experimental sample plots at Jilin Wangqing Forestry Bureau in China. The simulation results strongly support the use of auxiliary technology for scientifically selecting trees for thinning, avoiding the subjectivity of the traditional manual selection. Selection is largely based on the uniform angle index and competition index. Hegyi's competition index and its improved version used in the algorithm provided almost identical simulation results, i.e., thinning intensities suggested by these indices for the first sample plot are 21.8% and 21.5%, respectively, and for the second plot are 21.3% and 21.1%, respectively. Thus, one of these competition indices can be used to select trees for thinning. The comprehensive competition index (CCI, a combination of an improved version of Hegyi's competition index with tree species mingling) can avoid the selection of individual trees with high mingling and help maintain the tree species diversity. CCI suggests thinning intensities of 18.3% and 18.4% for the first and second sample plots, respectively. Presented methods and results may provide auxiliary supports for scientific thinning and help promote the application of information technology in forest management. [ABSTRACT FROM AUTHOR]

Tropospheric delay (TD) parameter estimation is a critical issue underlying high-precision data processing for global navigation satellite systems (GNSSs). The most widely used TD parameter estimation methods are the random walk (RW) and piece-wise constant (PWC). The RW method can effectively track rapid variations of tropospheric delay, but it may introduce excessive noise. In contrast, the PWC method introduces less noise, but it is less adaptable to cases of large variations of tropospheric delay. To address the problem of how to choose the optimal TD parameter estimation method, this paper investigates the variation patterns of international GNSS service zenith tropospheric delay (IGS ZTD) products and proposes a combined strategy model for TD parameter estimation. Firstly, this paper avoids the day-boundary jumps problem of IGS ZTD products by grouping based on single-day data. Secondly, this paper introduces discrete point areas (DPAs) to measure the magnitude of the ZTD values and uses comprehensive indicators to reflect the variation of ZTD. Next, based on the Köppen-Geiger climate classification, this study selected five different climate classifications with a total of 20 IGS stations as experimental data. The data assessed span from day of year (DOY) 001 to DOY 365 in 2022. This paper then applied 26 different parameter estimation strategies for static precise point positioning (PPP) data processing, and the parameter estimation strategies that were used include the RW and PWC (with the piece-wise constant ranging from twenty minutes to five hundred minutes at twenty-minute intervals). Finally, ZTD and positioning results were obtained using various parameter estimation methods, and a combined strategy model was established. We selected five different climate classifications of IGS stations as validation data and designed three sets of comparative experiments: RW, PWC120, and the combined strategy model, to verify the effectiveness of the combined strategy model. The experimental results revealed that: RW and the combined strategy model have a comparable ZTD accuracy and both are superior to PWC120. The combined strategy model improves the positioning accuracy in the U direction compared to RW and PWC120. In arid (B) and polar (E) regions with a small variation of TD, the PWC120 strategy displayed a better positioning accuracy than the RW strategy; in equatorial (A) and warm-temperate (C) regions, where there are large variations of TD, the RW strategy exhibited a better positioning accuracy than the PWC120 strategy. The combined strategy model can flexibly select the optimal parameter estimation method according to the comprehensive indicator while ensuring ZTD estimation accuracy; it enhances positioning accuracy. [ABSTRACT FROM AUTHOR]

Background: Rowell syndrome (RS) is an uncommon condition characterized by erythema multiforme (EM)‐like lesions and lupus erythematosus. It is more common in females, and EM may be the first manifestation of the disease with positive autoantibodies, such as antinuclear antibody (ANA), SSA, SSB and rheumatoid factor. The pathogenesis of RS is unknown and is likely caused by drug induction, ultraviolet exposure and infection. Method: We describe a case of RS from China which presented as characteristic targetoid‐like lesions and chilblain‐like erythema on hands and feet. This is a case of RS in a female patient from the inpatient department of dermatology. Results: A 41‐year‐old female with systemic lupus erythematosus exhibited chilblain‐like erythema and characteristic EM lesions on her extremities. She tested positive for serum ANA (1:320) and anti‐double‐stranded DNA, as well as other autoantibodies. Systemic glucocorticoids and hydroxychloroquine worked effectively for her. Conclusion: The present case met diagnostic criteria of RS. Notably, there was a co‑occurrence of facial butterfly erythema, chilblain‐like erythema and EM lesions distributed on the limbs in this case. [ABSTRACT FROM AUTHOR]

Functional principal component analysis (FPCA) has been widely used to capture major modes of variation and reduce dimensions in functional data analysis. However, standard FPCA based on the sample covariance estimator does not work well if the data exhibits heavy‐tailedness or outliers. To address this challenge, a new robust FPCA approach based on a functional pairwise spatial sign (PASS) operator, termed PASS FPCA, is introduced. We propose robust estimation procedures for eigenfunctions and eigenvalues. Theoretical properties of the PASS operator are established, showing that it adopts the same eigenfunctions as the standard covariance operator and also allows recovering ratios between eigenvalues. We also extend the proposed procedure to handle functional data measured with noise. Compared to existing robust FPCA approaches, the proposed PASS FPCA requires weaker distributional assumptions to conserve the eigenspace of the covariance function. Specifically, existing work are often built upon a class of functional elliptical distributions, which requires inherently symmetry. In contrast, we introduce a class of distributions called the weakly functional coordinate symmetry (weakly FCS), which allows for severe asymmetry and is much more flexible than the functional elliptical distribution family. The robustness of the PASS FPCA is demonstrated via extensive simulation studies, especially its advantages in scenarios with nonelliptical distributions. The proposed method was motivated by and applied to analysis of accelerometry data from the Objective Physical Activity and Cardiovascular Health Study, a large‐scale epidemiological study to investigate the relationship between objectively measured physical activity and cardiovascular health among older women. [ABSTRACT FROM AUTHOR]

The meiotic entry of undifferentiated germ cells is sexually specific and strictly regulated by the testicular or ovarian environment. Germline stem cells with a set of abnormal sex chromosomes and associated autosomes undergo defective meiotic processes and are eventually eliminated by yet to be defined post‐transcriptional modifications. Herein, we report the role of gsdf, a member of BMP/TGFβ family uniquely found in teleost, in the regulation of meiotic entry in medaka (Oryzias latipes) via analyses of gametogenesis in gsdf‐deficient XX and XY gonads in comparison with their wild‐type siblings. Several differentially expressed genes, including the FKB506‐binding protein 7 (fkbp7), were significantly upregulated in pubertal gsdf‐deficient gonads. The increase in alternative pre‐mRNA isoforms of meiotic synaptonemal complex gene sycp3 was visualized using Integrative Genomics Viewer and confirmed by real‐time qPCR. Nevertheless, immunofluorescence analysis showed that Sycp3 protein products reduced significantly in gsdf‐deficient XY oocytes. Transmission electron microscope observations showed that normal synchronous cysts were replaced by asynchronous cysts in gsdf‐deficient testis. Breeding experiments showed that the sex ratio deviation of gsdf−/− XY gametes in a non‐Mendelian manner might be due to the non‐segregation of XY chromosomes. Taken together, our results suggest that gsdf plays a role in the proper execution of cytoplasmic and nuclear events through receptor Smad phosphorylation and Sycp3 dephosphorylation to coordinate medaka gametogenesis, including sex‐specific mitotic divisions and meiotic recombination. [ABSTRACT FROM AUTHOR]