1. Bioinformatic Analysis of Correlation between Immune Infiltration and COVID-19 in Cancer Patients
- Author
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Jun Wang, Anna Kan, Shuxin Sun, Xin Hua, Chaobin He, Shengping Li, and Xin Huang
- Subjects
Male ,ACE2 ,Applied Microbiology and Biotechnology ,Neoplasms ,Genotype ,RNA-Seq ,Respiratory system ,0303 health sciences ,Stomach ,Prognosis ,Gene Expression Regulation, Neoplastic ,Kidney Tubules ,medicine.anatomical_structure ,Female ,Angiotensin-Converting Enzyme 2 ,Goblet Cells ,Signal transduction ,Coronavirus Infections ,hormones, hormone substitutes, and hormone antagonists ,Signal Transduction ,Research Paper ,Adult ,Gene Expression Regulation, Viral ,Urinary system ,Pneumonia, Viral ,Peptidyl-Dipeptidase A ,Biology ,Betacoronavirus ,03 medical and health sciences ,Immune system ,medicine ,Humans ,cancer ,Pandemics ,Molecular Biology ,Ecology, Evolution, Behavior and Systematics ,030304 developmental biology ,SARS-CoV-2 ,immune infiltration ,Gene Expression Profiling ,Computational Biology ,Cancer ,COVID-19 ,Epithelial Cells ,Cell Biology ,medicine.disease ,Gene expression profiling ,Enterocytes ,Immune System ,Hepatocytes ,Cancer research ,Developmental Biology - Abstract
In 2020, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused infections worldwide. However, the correlation between the immune infiltration and coronavirus disease 2019 (COVID-19) susceptibility or severity in cancer patients remains to be fully elucidated. ACE2 expressions in normal tissues, cancers and cell lines were comprehensively assessed. Furthermore, we compared ACE2 expression between cancers and matched normal tissues through Gene Expression Profiling Interactive Analysis (GEPIA). In addition, we performed gene set enrichment analysis (GSEA) to investigate the related signaling pathways. Finally, the correlations between ACE2 expression and immune infiltration were investigated via Tumor Immune Estimation Resource (TIMER) and GEPIA. We found that ACE2 was predominantly expressed in both adult and fetal tissues from the digestive, urinary and male reproductive tracts; moreover, ACE2 expressions in corresponding cancers were generally higher than that in matched healthy tissues. GSEA showed that various metabolic and immune-related pathways were significantly associated with ACE2 expression across multiple cancer types. Intriguingly, we found that ACE2 expression correlated significantly with immune cell infiltration in both normal and cancer tissues, especially in the stomach and colon. These findings proposed a possible fecal-oral and maternal-fetal transmission of SARS-CoV-2 and suggested that cancers of the respiratory, digestive or urinary tracts would be more vulnerable to SARS-CoV-2 infection.
- Published
- 2020