7 results on '"Sinha, Sanjeev"'
Search Results
2. Lean Mass Improvement from Nutrition Education and Protein Supplementation among Rural Indian Women Living with HIV/AIDS: Results from Cluster Randomized Factorial Trial at 18-Month Follow-Up
- Author
-
Carpenter, Catherine L, Kapur, Kavita, Ramakrishna, Padma, Pamujula, Suresh, Yadav, Kartik, Giovanni, Jennifer E, Julian, Olivia, Ekstrand, Maria L, Sinha, Sanjeev, and Nyamathi, Adeline M
- Subjects
Biomedical and Clinical Sciences ,Public Health ,Health Sciences ,Clinical Research ,Clinical Trials and Supportive Activities ,Prevention ,Behavioral and Social Science ,Nutrition ,HIV/AIDS ,Infectious Diseases ,Acquired Immunodeficiency Syndrome ,Body Composition ,Counseling ,Dietary Proteins ,Dietary Supplements ,Female ,Follow-Up Studies ,Health Education ,Humans ,India ,Nutrition Therapy ,Nutritional Physiological Phenomena ,Rural Population ,Time Factors ,lean mass ,HIV ,AIDS ,protein ,nutrition ,cluster-randomized trial ,Food Sciences ,Nutrition and Dietetics ,Clinical sciences ,Nutrition and dietetics ,Public health - Abstract
Loss of lean muscle mass impairs immunity and increases mortality risk among individuals with HIV/AIDS. We evaluated the relative contributions of protein supplementation and nutrition education on body composition among 600 women living with HIV/AIDS in rural Andhra Pradesh, India. We conducted a cluster randomized controlled 2 × 2 factorial trial lasting six months with follow up at twelve and eighteen months. Interventions occurred in the Nellore and Prakasam regions of Andhra Pradesh by trained village women, ASHA (Accredited Social Health Activists), and included: (1) the usual supportive care from ASHA (UC); (2) UC plus nutrition education (NE); (3) UC plus nutritional protein supplementation (NS); (4) combined UC plus NE plus NS. A Bioimpedance Analyzer Model 310e measured body composition. SAS 9.4 analyzed all data. Mixed models using repeated measures evaluated lean mass change from baseline as primary and fat weight and total weight as secondary outcomes. Lean mass change was significantly associated with NS (p = 0.0001), NE (p = 0.0001), and combined NS plus NE (p = 0.0001), with similar associations for secondary outcomes. Stronger associations for total weight were observed with greater ART adherence. Nutritional interventions may improve physiologic response to HIV. Significant increases in lean mass resulted from independent and combined protein supplementation and nutrition education.
- Published
- 2022
3. Depression, social support, and stigma as predictors of quality of life over time: results from an Asha-based HIV/AIDS intervention in India.
- Author
-
Garfin, Dana Rose, Shin, Sanghyuk S, Ekstrand, Maria L, Yadav, Kartik, Carpenter, Catherine L, Sinha, Sanjeev, and Nyamathi, Adeline M
- Subjects
Humans ,HIV Infections ,Antiretroviral Therapy ,Highly Active ,Depression ,Quality of Life ,Social Support ,Adult ,Middle Aged ,India ,Female ,Male ,Social Stigma ,Self Report ,AIDS ,HIV ,Latent Class Analysis ,depression ,quality of life ,social support ,stigma ,Clinical Research ,HIV/AIDS ,Mental Health ,Infectious Diseases ,Behavioral and Social Science ,Good Health and Well Being ,Public Health and Health Services ,Psychology ,Public Health - Abstract
Quality of life (QOL) is associated with better outcomes in HIV/AIDS populations. We explored predictors of improved QOL over time in 600 Women Living with HIV/AIDS (WLH/A) in India [mean age = 34.31, SD = 6.97], enrolled in a nurse-led-Asha (Accredited Social Health Activist) intervention. Trained local interviewers ascertained self-report data at baseline and six-month follow-up (post-intervention). Latent Class Analysis (LCA) identified constellations of responses on psychosocial indicators (depression, social support, internalized stigma and stigma fears); their relationship with QOL over time was examined. We identified three classes: Class 1) Highest Social Resources/Lowest Depression; Class 2) Some Social Resources/Highest Depression; and Class 3) Lowest Social Resources/Higher Depression. At baseline, Class 3 reported the lowest QOL (M = 0.25, SD = 0.26); Class 1 reported the highest (M = 0.37, SD = 0.33). Class 2's QOL did not differ from Class 3's QOL, likely due to the potent effects of high depression. At six-month follow-up, all groups reported improved QOL; class membership no longer predicted variability (contrast between Class 2 and 1 = -0.05, 95% CI = -0.14, 0.04; contrast between Class 3 and 1 = 0.01, 95% CI = -0.03, 0.05; contrast between Class 3 and 2 = 0.07, 95% CI = -0.02, 0.16). Psychosocial indicators are important predictors of QOL; an Asha-supported approach may have broad applicability to improve QOL in WLH/A in India.
- Published
- 2019
4. Relationships Among Adherence and Physical and Mental Health Among Women Living with HIV in Rural India
- Author
-
Nyamathi, Adeline, Ekstrand, Maria, Heylen, Elsa, Ramakrishna, Padma, Yadav, Kartik, Sinha, Sanjeev, Hudson, Angela, Carpenter, Catherine L, and Arab, Lenore
- Subjects
Health Services and Systems ,Public Health ,Health Sciences ,Behavioral and Social Science ,Mind and Body ,Infectious Diseases ,Clinical Research ,HIV/AIDS ,Prevention ,Mental Health ,Good Health and Well Being ,Zero Hunger ,Adult ,Anti-Retroviral Agents ,CD4 Lymphocyte Count ,Cross-Sectional Studies ,Depression ,Female ,Food Supply ,HIV Infections ,Health Status ,Humans ,India ,Male ,Medication Adherence ,Middle Aged ,Quality of Life ,Rural Population ,Social Stigma ,Women ,AIDS ,Opportunistic infections ,Public Health and Health Services ,Social Work ,Public health - Abstract
We conducted a cross-sectional examination of the physical and psychological factors related to ART adherence among a sample of 400 women living with HIV/AIDS in rural India. Interviewer-administered measures assessed adherence, internalized stigma, depressive symptoms, quality of life, food insecurity, health history and sociodemographic information. CD4 counts were measured using blood collected at screening. Findings revealed that adherence to ART was generally low, with 94% of women taking 50% or less of prescribed medication in past month. Multivariate analyses showed a non-linear association between numbers of self-reported opportunistic infections (OIs) in past 6 months (p = 0.016) and adherence, with adherence decreasing with each additional OI for 0-5 OIs. For those reporting more than 5 OIs, the association reversed direction, with increasing OIs beyond 5 associated with greater adherence.
- Published
- 2018
5. Women living with AIDS in rural Southern India: Perspectives on mental health and lay health care worker support
- Author
-
Srivastava, Neha, Nyamathi, Adeline M, Sinha, Sanjeev, Carpenter, Catherine, Satyanarayana, Veena, Ramakrishnan, Padma, and Ekstrand, Maria
- Subjects
Health Services and Systems ,Health Sciences ,Mental Health ,Clinical Research ,Behavioral and Social Science ,7.1 Individual care needs ,Management of diseases and conditions ,Mental health ,Good Health and Well Being ,AIDS ,coping resources ,India ,mental health ,women ,Women ,Public Health and Health Services ,Social Work ,Public Health ,Public health ,Social work - Abstract
In this study, focus groups were conducted with 16 rural Women Living with AIDS (WLA) from Andhra Pradesh, India who had previously participated in a clinical trial wherein 68 WLA were randomized into either an Accredited Social Health Activists (ASHA) - Life (AL) intervention or a Usual Care program. Findings are discussed in terms of: a) mental health issues, b) perceived stressors, c) individual resources for coping with mental health issues, and d) role of Asha support in coping with mental health issues. These findings highlight the salience of mental health issues in the lives of WLA and the role played by Asha in addressing some of these issues. The discussion section makes a case for increased emphasis on mental health care in future community-based interventions for this population.
- Published
- 2017
6. Immunological alterations in tuberculosis associated immune reconstitution inflammatory syndrome in HIV infected patients.
- Author
-
Verma, Chaitenya, Sharma, Surendra K., Natarajan, Krishnamurthi, Sreenivas, Vishnu, Upadhyay, Vishwanath, Sinha, Sanjeev, Ranjan, Sanjay, Mehra, Narinder K., Kaur, Gurvinder, and Hari, Smriti
- Subjects
IMMUNE reconstitution inflammatory syndrome ,AIDS ,CHEMOKINES ,HIV-positive persons ,T cells - Abstract
The tuberculosis associated immune reconstitution inflammatory syndrome (TB-IRIS) frequently complicates the course of HIV/AIDS and HIV-TB treatment and its immunological mechanisms are poorly understood. Here, we investigated T-cells frequencies, their secreted chemokines and cytokines. In this prospective case-control study, HIV/AIDS and HIV-TB patients during treatment with highly active antiretroviral treatment (HAART) and anti-TB treatment were followed for TB-IRIS development. Age, gender and BMI-matched patients without IRIS constituted as "Controls" (non-IRIS). Activation and proliferation were assessed in CD4 and CD8 cell compartments. CCR4, CCR6 and T-reg cells were also analysed in PBMCs. Cytokines (IL-2, IL-4, IL-10, IFN-γ and TGF-β1) and chemokines (IP-10, MCP-1, MIG and RANTES) were measured in culture supernatants. Of 560 enrolled HIV/AIDS patients, TB-IRIS developed in 50 (8.9%) patients (25-paradoxical and 25-unmasking) at a median interval of 35-days (IQR, 24-78). After ART therapy, CD8+ T-cell proportion decreased in both paradoxical and unmasking-TB-IRIS as compared to non-IRIS. Simultaneously, activation of CD4+ T-cells was observed in unmasking TB-IRIS only. Similarly, CD161+ T-cells, Th17-cells and inflammatory cytokines like IFN-γ, IP-10 and MIG elevated in both TB-IRIS subgroups as compared to non-IRIS.In conclusion, during HAART treatment the dominance of pro-inflammatory cells and cytokines in TB-IRIS patients favours the development of IRIS event. On the other hand, in non- IRIS patients relative increase of anti-inflammatory cells and cytokines prevents the development of IRIS event. [ABSTRACT FROM AUTHOR]
- Published
- 2019
7. Case control study: magnetic resonance spectroscopy of brain in HIV infected patients.
- Author
-
Bairwa, Devender, Kumar, Virendra, Vyas, Surabhi, Kumar Das, Bimal, Kumar Srivastava, Achal, Pandey, Ravinder M., Sharma, Surendra K., Jagannathan, Naranamangalam R., Sinha, Sanjeev, Das, Bimal Kumar, and Srivastava, Achal Kumar
- Subjects
PROTON magnetic resonance spectroscopy ,HIV-positive persons ,BIOMARKERS ,BASAL ganglia ,METABOLIC disorders ,ASPARTIC acid metabolism ,BRAIN metabolism ,GLUTAMINE metabolism ,GLUTAMIC acid metabolism ,ASPARTIC acid ,CHOLINE ,CREATINE ,FRONTAL lobe ,GENETIC disorders ,HIV infections ,INOSITOL ,LIPID metabolism disorders ,MAGNETIC resonance imaging ,MOLECULAR structure ,NEURORADIOLOGY ,OLIGOPEPTIDES ,CASE-control method - Abstract
Background: In vivo proton magnetic resonance spectroscopy ((1)H-MRS) studies on brain in HIV infected patients have shown significant alteration in neuro-biochemicals.Methods: In this study, we measured the neuro-biochemical metabolites from the left frontal white matter (FWM) and left basal ganglia (BG) caudate head nucleus in 71 subjects that include 30 healthy controls, 20 asymptomatic HIV and 21 HIV patients with CNS lesion. Proton MR spectra were acquired at 3 T MRI system and the concentration (institutional units) of tNAA (N-acetylaspartate, NAA + N-acetylaspartylglutamate, NAAG), tCr (Creatine, Cr + phosphocreatine, PCr), choline containing compounds (tCho), glutamate + glutamine (Glx) and lipid and macromolecules at 0.9 ppm were determined using LC Model.Results: In BG, the concentration of tNAA (6.71 ± 0.64) was decreased and in FWM, the concentration of Glx (20.4 ± 7.8), tCr (9.14 ± 3.04) and lipid and macromolecules at 0.9 ppm (8.69 ± 2.96) were increased in HIV patients with CNS lesion. In healthy controls, the concentration of tNAA in BG was 7.31 ± 0.47 and concentration of Glx, tCr and lipid and macromolecules in FWM were 15.0 ± 6.06, 6.95 ± 2.56, 5.59 ± 1.56, respectively.Conclusion: Reduced tNAA in BG suggests neuronal loss in HIV patients with CNS lesion while increased Glx in FWM may suggest excito-toxicity. In addition, increased levels of tCr in FWM of HIV patients were observed. The study indicates region specific metabolic changes in tNAA, tCr and Glx in brain of HIV infected patients. [ABSTRACT FROM AUTHOR]- Published
- 2016
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.