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Your search keyword '"Pali-Schöll, Isabella"' showing total 4 results
Start Over Author "Pali-Schöll, Isabella" Topic allergens Topic immunoglobulin e Publication Year Range Last 10 years
4 results on '"Pali-Schöll, Isabella"'

1. Retinoic acid‐loading of the major birch pollen allergen Bet v 1 may improve specific allergen immunotherapy: In silico, in vitro and in vivo data in BALB/c mice.

Author

Hufnagl, Karin, Afify, Sheriene Moussa, Braun, Nina, Wagner, Stefanie, Wallner, Michael, Hauser, Michael, Wiederstein, Markus, Gadermaier, Gabriele, Wildner, Sabrina, Redegeld, Frank A., Blokhuis, Bart R., Hofstetter, Gerlinde, Pali‐Schöll, Isabella, Roth‐Walter, Franziska, Pacios, Luis F., and Jensen‐Jarolim, Erika

Subjects
IMMUNOGLOBULIN E, TRETINOIN, POLLEN, ALLERGENS, BIRCH, IMMUNOTHERAPY
Abstract

Retinoic acid-loading of the major birch pollen allergen Bet v 1 may improve specific allergen immunotherapy: In silico, in vitro and in vivo data in BALB/c mice Even if this was not due to altered endolysosomal stability of Bet v 1a due to RA binding (Figure S3), it seemed so far like RA-loading transforms the hyperallergen Bet v 1a to a hypoallergen with improved tolerogenic capacity of potential implications for allergen immunotherapy. Mice were first made allergic against the major birch pollen allergen Bet v 1a and subsequently treated intranasally with either the I apo i -Bet v 1a, or with the RA-loaded I holo i -Bet v 1a, or as a control with RA alone. [Extracted from the article]

Published
2020
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2. A distinct microbiota composition is associated with protection from food allergy in an oral mouse immunization model

Author

Diesner, Susanne C., Bergmayr, Cornelia, Pfitzner, Barbara, Assmann, Vera, Krishnamurthy, Durga, Starkl, Philipp, Endesfelder, David, Rothballer, Michael, Welzl, Gerhard, Rattei, Thomas, Eiwegger, Thomas, Szépfalusi, Zsolt, Fehrenbach, Heinz, Jensen-Jarolim, Erika, Hartmann, Anton, Pali-Schöll, Isabella, and Untersmayr, Eva

Subjects
Ovalbumin, Sucralfate, Immunology, Administration, Oral, Intestinal barrier function, Article, Gastric Acid, Feces, Food allergy, Bacterial community composition, Animals, Immunology and Allergy, Anaphylaxis, Mice, Inbred BALB C, Bacteria, Microbiota, Stomach, Allergens, Immunoglobulin E, Anti-Ulcer Agents, Immunoglobulin A, Intestines, Disease Models, Animal, Allergen Uptake, Bacterial Community Composition, Cytokines, Food Allergy, Intestinal Barrier Function, Immunoglobulin G, Female, Immunization, Food Hypersensitivity, Spleen, Allergen uptake
Abstract

In our mouse model, gastric acid-suppression is associated with antigen-specific IgE and anaphylaxis development. We repeatedly observed non-responder animals protected from food allergy. Here, we aimed to analyse reasons for this protection. Ten out of 64 mice, subjected to oral ovalbumin (OVA) immunizations under gastric acid-suppression, were non-responders without OVA-specific IgE or IgG1 elevation, indicating protection from allergy. In these non-responders, allergen challenges confirmed reduced antigen uptake and lack of anaphylactic symptoms, while in allergic mice high levels of mouse mast-cell protease-1 and a body temperature reduction, indicative for anaphylaxis, were determined. Upon OVA stimulation, significantly lower IL-4, IL-5, IL-10 and IL-13 levels were detected in non-responders, while IL-22 was significantly higher. Comparison of fecal microbiota revealed differences of bacterial communities on single bacterial Operational-Taxonomic-Unit level between the groups, indicating protection from food allergy being associated with a distinct microbiota composition in a non-responding phenotype in this mouse model.

Published
2016

3. The concept of allergen-associated molecular patterns (AAMP).

Author

Pali-Schöll, Isabella and Jensen-Jarolim, Erika

Subjects
*ALLERGENS, *PATTERN perception, *B cell receptors, *IMMUNOGLOBULIN E, *OLIGOMERIZATION, *EPITOPES
Abstract

For proteins to become allergenic, they need to acquire features enabling them to induce B cell activation and isotype switch to IgE production. Crosslinking of the B-cell receptor (BCR) is the most efficient way to productively activate B-cells. The IgE-crosslinking capability of allergens is equally crucial in the effector phase of immediate type allergy. Antigens, which acquire enhanced crosslinking capacity by oligomerization, aggregation, or the expression of repetitive epitopes may therefore gain allergenic potency. The accumulated evidence for repetitive epitope display by allergens suggests the existence of allergen-associated molecular patterns. [ABSTRACT FROM AUTHOR]

Published
2016
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4. Micronutritional supplementation with a holoBLG-based FSMP (food for special medical purposes)-lozenge alleviates allergic symptoms in BALB/c mice: Imitating the protective farm effect

Author

Karin Hufnagl, Erika Jensen-Jarolim, Rodolfo Bianchini, Andreas Regner, Franziska Roth-Walter, Zdenek Dvorak, Luis F. Pacios, Matthias F. Kramer, Bart R. Blokhuis, Alessandro Fiocchi, Sheriene Moussa Afify, Sebastian A. Jensen, Sonja Guethoff, Frank A. Redegeld, Isabella Pali-Schöll, Afd Pharmacology, Pharmacology, Biomedical International R+D GmbH, Austrian Science Fund, Bencard Allergie GmbH, Afify, Sheriene Moussa, Pacios, Luis F, Redegeld, Frank A, Pali-Schöll, Isabella, Hufnagl, Karin, Bianchini, Rodolfo, Guethoff, Sonja, Kramer, Matthias F, Fiocchi, Alessandro, Dvorak, Zdenek, Jensen-Jarolim, Erika, Roth-Walter, Franziska, Afify, Sheriene Moussa [0000-0003-2082-9038], Pacios, Luis F [0000-0002-0585-4289], Redegeld, Frank A [0000-0001-8830-7960], Pali-Schöll, Isabella [0000-0003-2089-6011], Hufnagl, Karin [0000-0002-2288-2468], Bianchini, Rodolfo [0000-0003-0351-6937], Guethoff, Sonja [0000-0001-5846-1035], Kramer, Matthias F [0000-0002-3740-4733], Fiocchi, Alessandro [0000-0002-2549-0523], Dvorak, Zdenek [0000-0002-3938-3585], Jensen-Jarolim, Erika [0000-0003-4019-5765], and Roth-Walter, Franziska [0000-0001-5005-9228]

Subjects
Farms, T cell, Antigen presentation, Immunology, Lactoglobulins, Immunoglobulin E, immunomodulation, BALB/c, Mice, Immune system, medicine, Animals, Humans, Immunology and Allergy, Antigen-presenting cell, immune resilience, Mice, Inbred BALB C, biology, beta-lactoglobulin, farm effect, Chemistry, Degranulation, holoBLG lozenge, Allergens, biology.organism_classification, medicine.anatomical_structure, food for special medical purposes FSMP, Dietary Supplements, biology.protein, Milk Hypersensitivity, Lozenge
Abstract

16 Pág., Previously, the protective farm effect was imitated using the whey protein beta-lactoglobulin (BLG) that is spiked with iron-flavonoid complexes. Here, we formulated for clinical translation a lozenge as food for special medical purposes (FSMP) using catechin-iron complexes as ligands for BLG. The lozenge was tested in vitro and in a therapeutical BALB/c mice model., The study was supported by Biomedical International R+D GmbH, Vienna, Austria and Bencard Allergie GmbH, Munich, Germany and in part by the Austrian Science Fund FWF, grant SFB F4606-B28.

Published
2022

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