1. Perillaldehyde: A promising antifungal agent to treat oropharyngeal candidiasis.
- Author
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Chen L, Qu S, Yang K, Liu M, Li YX, Keller NP, Zeng X, and Tian J
- Subjects
- Animals, Antifungal Agents pharmacology, Candida albicans physiology, Candidiasis, Oral pathology, Dose-Response Relationship, Drug, Mice, Mice, Inbred C57BL, Monoterpenes pharmacology, Pharyngeal Diseases microbiology, Pharyngeal Diseases pathology, Random Allocation, Antifungal Agents therapeutic use, Candida albicans drug effects, Candidiasis, Oral drug therapy, Monoterpenes therapeutic use, Pharyngeal Diseases drug therapy
- Abstract
Perillaldehyde (PAE), a natural monoterpenoid agent extracted from Perilla frutescence, PAE has been reported to present various physiological capabilities, such as anti-inflammation, anti-oxidative and anti-fungal. In this study, we show that PAE exhibits strong antifungal activity against Candida albicans (C. albicans). C. albicans, a fungal pathogen with high incidence of antifungal resistance in clinical settings, is the major cause of oropharyngeal candidiasis (OPC). OPC is characterized by inflammatory immunological responses to fungal infections. Our in vitro results show PAE inhibited several virulence attributes of C. albicans including biofilm formation, yeast-to-hyphal transition and secreted aspartic proteinases (SAPs) gene expression. Using an experimental murine model of OPC, we found that PAE inhibited NLRP3 inflammasome assembly, reduced the excessive accumulation of ROS and prevented the p65 transfer in nuclear; processes all leading to reduced inflammation burden in the host. Together, this supports use PAE as a promising new agent to improve OPC., (Copyright © 2020 Elsevier Inc. All rights reserved.)
- Published
- 2020
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