1. The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits
- Author
-
Lusis, Aldons J, Seldin, Marcus M, Allayee, Hooman, Bennett, Brian J, Civelek, Mete, Davis, Richard C, Eskin, Eleazar, Farber, Charles R, Hui, Simon, Mehrabian, Margarete, Norheim, Frode, Pan, Calvin, Parks, Brian, Rau, Christoph D, Smith, Desmond J, Vallim, Thomas, Wang, Yibin, and Wang, Jessica
- Subjects
Biological Sciences ,Biomedical and Clinical Sciences ,Genetics ,Biotechnology ,Cardiovascular ,Nutrition ,Human Genome ,Aging ,Aetiology ,2.1 Biological and endogenous factors ,Metabolic and endocrine ,Oral and gastrointestinal ,Animals ,Atherosclerosis ,Cardiovascular Diseases ,Disease Models ,Animal ,Genome-Wide Association Study ,Heart Failure ,Humans ,Hybridization ,Genetic ,Insulin Resistance ,Metabolic Diseases ,Mice ,Microbiota ,Obesity ,Osteoporosis ,Quantitative Trait Loci ,Transcriptome ,aherosclerosis ,osteoporosis ,obesity ,heart failure ,microbiota ,gene-by-diet interaction ,gene expression ,insulin resistance ,gene mapping ,Biochemistry and Cell Biology ,Medical Biochemistry and Metabolomics ,Biochemistry & Molecular Biology ,Biochemistry and cell biology ,Medical biochemistry and metabolomics - Abstract
The Hybrid Mouse Diversity Panel (HMDP) is a collection of approximately 100 well-characterized inbred strains of mice that can be used to analyze the genetic and environmental factors underlying complex traits. While not nearly as powerful for mapping genetic loci contributing to the traits as human genome-wide association studies, it has some important advantages. First, environmental factors can be controlled. Second, relevant tissues are accessible for global molecular phenotyping. Finally, because inbred strains are renewable, results from separate studies can be integrated. Thus far, the HMDP has been studied for traits relevant to obesity, diabetes, atherosclerosis, osteoporosis, heart failure, immune regulation, fatty liver disease, and host-gut microbiota interactions. High-throughput technologies have been used to examine the genomes, epigenomes, transcriptomes, proteomes, metabolomes, and microbiomes of the mice under various environmental conditions. All of the published data are available and can be readily used to formulate hypotheses about genes, pathways and interactions.
- Published
- 2016