1. Identification of Prognostic and Therapeutic Biomarkers among FAM83 Family Members for Pancreatic Ductal Adenocarcinoma.
- Author
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Ma Z, Zhou Z, Zhuang H, Li Z, Ma Z, Huang B, Liu C, Gong Y, Zou Y, Zheng Z, Huang S, Zhang C, and Hou B
- Subjects
- Biomarkers, Tumor metabolism, Carcinoma, Pancreatic Ductal genetics, Carcinoma, Pancreatic Ductal pathology, Cell Cycle Proteins metabolism, Cell Movement, Humans, Microtubule-Associated Proteins metabolism, Neoplasm Invasiveness, Neoplasm Proteins metabolism, Pancreatic Neoplasms genetics, Pancreatic Neoplasms pathology, Proteins metabolism, Proto-Oncogene Proteins p21(ras) genetics, Proto-Oncogene Proteins p21(ras) metabolism, Smad4 Protein genetics, Smad4 Protein metabolism, T-Lymphocytes physiology, Up-Regulation, Biomarkers, Tumor genetics, Carcinoma, Pancreatic Ductal metabolism, Cell Cycle Proteins genetics, Microtubule-Associated Proteins genetics, Neoplasm Proteins genetics, Pancreatic Neoplasms metabolism, Proteins genetics
- Abstract
Family with sequence similarity 83 (FAM83) members were shown recently to have oncogenic effect in a variety of cancer types, but the biological roles and prognostic value of FAM83 family in pancreatic ductal adenocarcinoma remain unknown. In the current study, the clinical significance and molecular function of the FAM83 family were assessed by multiple bioinformatics analysis. Besides, potential associations between differentially expressed genes (DEGs) of FAM83 family and antitumor immunity were evaluated using TIMER and TISIDB analyses. As the results show, FAM83A, FAM83D, FAM83E, and FAM83H were significantly upregulated in PDAC and were identified as DEGs. Higher expression of FAM83A, FAM83B, FAM83D, FAM83E, and FAM83H were associated with advanced tumor stage or worse patient prognosis. Importantly, the overexpression of DEGs was found to be significantly correlated with activated KRAS and loss of SMAD4, which are important drivers for PDAC. Further, FAM83A, FAM83D, and FAM83H were associated with CD8
+ T cell, Gamma Delta T cell, and CD4+ T cell infiltration in PDAC and FAM83H was found closely correlated with some immunomodulators including immunoinhibitors, immunostimulators, and MHC molecules. In conclusion, FAM83A, FAM83D, FAM83E, and FAM83H have significant prognostic value in PDAC and they may play important roles in regulating tumor progression and the immune cell infiltration., Competing Interests: The authors declare that they have no potential conflicts of interest., (Copyright © 2021 Zuyi Ma et al.)- Published
- 2021
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