6 results on '"De Cesaris, Francesco"'
Search Results
2. Protocol and methods for testing the efficacy of well-being therapy in chronic migraine patients: a randomized controlled trial
- Author
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Mansueto, Giovanni, De Cesaris, Francesco, Geppetti, Pierangelo, and Cosci, Fiammetta
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- 2018
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3. Effectiveness of anti-CGRP monoclonal antibodies on central symptoms of migraine.
- Author
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Iannone, Luigi Francesco, De Cesaris, Francesco, Ferrari, Anita, Benemei, Silvia, Fattori, Davide, and Chiarugi, Alberto
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MONOCLONAL antibodies , *MIGRAINE aura , *MIGRAINE , *ERENUMAB , *PEPTIDES , *PANIC attacks - Abstract
Background: Clinical trials and observational studies with anti-calcitonin gene-related peptide antibodies poorly investigated their impact on migraine prodromal and accompanying symptoms. This information might help deciphering the biologics' pharmacodynamic and provide hints on migraine pathogenesis. Herein, we report the effects of erenumab, fremanezumab and galcanezumab on attack prodromal and accompanying symptoms and on neurological and psychiatric traits. Methods: An explorative, prospective, questionnaire-based study was completed by a cohort (n = 80) of patients with chronic migraine patients presenting a sustained reduction of ≥50% of Migraine Disability Assessment Score and ≥30% of monthly migraine days three months after anti-calcitonin gene-related peptide antibodies treatment. Results: The majority of patients experienced a complete prevention of migraine symptoms without evidence of initial onset followed by attack abortion. Few patients reported the recurrence of prodromal (from 10% to 12.5%) or accompanying (from 1.3% to 8.8%) symptoms without headache. All patients with migraine with aura reported a decrease of aura incidence. Sleep changes (51.2%), increase in appetite (20.0%) and weight (18.8%) as well as a reduction in stress (45.0%), anxiety (26.3%), and panic attacks (15%) were also reported. Conclusion: Anti-calcitonin gene-related peptide antibodies seems to significantly impact brain functions of migraineurs, preventing not only migraine headache but also its anticipatory and accompanying symptoms. [ABSTRACT FROM AUTHOR]
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- 2022
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4. Predictors of sustained response and effects of the discontinuation of anti‐calcitonin gene related peptide antibodies and reinitiation in resistant chronic migraine.
- Author
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Iannone, Luigi Francesco, Fattori, Davide, Benemei, Silvia, Chiarugi, Alberto, Geppetti, Pierangelo, and De Cesaris, Francesco
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PEPTIDES ,MIGRAINE ,ERENUMAB ,IMPACT testing ,IMMUNOGLOBULINS ,CD20 antigen ,BOTULINUM A toxins - Abstract
Background and purpose: Guidelines for migraine prophylaxis suggest stopping medication after 6–12 months to reevaluate treatment appropriateness. The Italian Medicines Agency set a mandatory regulation to stop anti‐calcitonin gene related protein (CGRP) pathway monoclonal antibody (anti‐CGRP mAb) treatments for 3 months after 12 months of treatment. Herein, the effects of discontinuation and retreatment of anti‐CGRP mAbs in resistant chronic migraine patients are assessed, evaluating predictive factors of sustained response. Methods: This was a monocentric prospective cohort study, enrolling 44 severe (resistant to ≥3 preventive treatments) chronic migraine patients (all with medication‐overuse), treated with erenumab (54.5%) or galcanezumab (45.5%) for 12 months, who discontinued treatment for 3 months and then restarted for 1 month. Results: Overall, patients reported an increasing deteriorating trend during the 3 months of discontinuation. Monthly migraine days, number of analgesics, days with at least one analgesic used, a ≥50% response rate (reduction in monthly migraine days), and Migraine Disability Assessment Score and Headache Impact Test 6 total score, remained lower than baseline values, but increased compared to month 12 of treatment. All outcome measures decreased again during the month of retreatment. Patients who did not meet criteria for restarting treatment had a lower Migraine Disability Assessment Score (p = 0.03) and Headache Impact Test 6 (p = 0.01) score at baseline and better outcome measures during discontinuation compared to patients who restarted treatment. Conclusions: In most patients, the 3‐month discontinuation of anti‐CGRP mAbs resulted in progressive migraine deterioration that was rapidly reverted by retreatment. However, one‐quarter of patients who reported better quality of life indices before treatment showed a sustained benefit during discontinuation and did not need retreatment. [ABSTRACT FROM AUTHOR]
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- 2022
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5. Epidemiology and determinants of chronic migraine: A real-world cohort study, with nested case-control analysis, in primary care in Italy.
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Marconi, Ettore, Pecchioli, Serena, Nica, Mihaela, Colombo, Delia, Mazzoleni, Francesco, De Cesaris, Francesco, Geppetti, Pierangelo, Cricelli, Claudio, and Lapi, Francesco
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MIGRAINE , *PRIMARY care , *EPIDEMIOLOGY , *COHORT analysis , *GENERAL practitioners , *MIGRAINE aura - Abstract
Background: The proper identification of chronic migraine is one of the mainstays for general practitioners. This study therefore aims to assess the epidemiology and determinants of chronic migraine in primary care in Italy by testing five operational case definition algorithms. Methods: Five case definition algorithms defining chronic migraine were developed to estimate the prevalence and incidence rate of chronic migraine in the Health Search database. For each algorithm, we conducted a nested case-control analysis to quantify the level of association between certain determinants and incident cases of chronic migraine. Results: Considering a cohort of 1,091,032 patients (52% were females), the prevalence rate of chronic migraine increased from the first to the fifth case definition algorithm ranging from 0.03 to 0.28%. No 95% confidence interval overlapped the others, and every confidence interval reliably maintained 2% precision. Incidence rates showed a growing trend (0.008–0.056 per 100,000 person-years) as well. All case definition algorithms were able to capture sex (i.e. female) and nonsteroidal anti-inflammatory drug (NSAID) overuse as statistically significant determinants of incident cases of chronic migraine. Depression was associated with a statistically significant increase of incidence rate of chronic migraine only for two case definition algorithms. Conclusion: Our findings show that prevalence and incidence rate of chronic migraine are underestimated when compared with current literature. On the other hand, we found acceptable correctness of chronic migraine definition in the light of the association with well-known determinants. [ABSTRACT FROM AUTHOR]
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- 2020
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6. Development and validation of the ID-EC - the ITALIAN version of the identify chronic migraine
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Maria Pia Prudenzano, Gianluca Coppola, Grazia Sances, Roberto De Icco, Simona Sacco, Paolo Martelletti, Valentina Taranta, Pietro Cortelli, Francesca Pistoia, Giulia Pierangeli, Antonio Russo, Cristina Tassorelli, Luigi Alberto Pini, Francesco Pierelli, Sabina Cevoli, Cristiano Maria De Marco, Maria Trojano, Silvia Benemei, Cherubino Di Lorenzo, Gioacchino Tedeschi, Francesco De Cesaris, Pierangelo Geppetti, Alessia Manni, Raffaele Ornello, Andrea Negro, Lanfranco Pellesi, Sacco, S., Benemei, S., Cevoli, S., Coppola, G., Cortelli, P., De Cesaris, F., De Icco, R., De Marco, C. M., Di Lorenzo, C., Geppetti, P., Manni, A., Negro, A., Ornello, R., Pierangeli, G., Pierelli, F., Pellesi, L., Pini, L. A., Pistoia, F., Prudenzano, M. P., Russo, A., Sances, G., Taranta, V., Tassorelli, C., Tedeschi, G., Trojano, M., Martelletti, P., Sacco, Simona, Benemei, Silvia, Cevoli, Sabina, Coppola, Gianluca, Cortelli, Pietro, De Cesaris, Francesco, De Icco, Roberto, De Marco, Cristiano Maria, Di Lorenzo, Cherubino, Geppetti, Pierangelo, Manni, Alessia, Negro, Andrea, Ornello, Raffaele, Pierangeli, Giulia, Pierelli, Francesco, Pellesi, Lanfranco, Pini, Luigi Alberto, Pistoia, Francesca, Prudenzano, Maria Pia, Russo, Antonio, Sances, Grazia, Taranta, Valentina, Tassorelli, Cristina, Tedeschi, Gioacchino, Trojano, Maria, and Martelletti, Paolo
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Male ,lcsh:Medicine ,0302 clinical medicine ,Chronic Migraine ,Migraine Disorder ,Surveys and Questionnaires ,Diagnosis ,Mass Screening ,Surveys and Questionnaire ,030212 general & internal medicine ,Program Development ,Medical diagnosis ,education.field_of_study ,General Medicine ,Health Survey ,Middle Aged ,Test (assessment) ,Italy ,chronic migraine ,diagnosis ,migraine ,neurology ,anesthesiology and pain medicine ,Female ,Research Article ,Diagnosi ,Human ,Adult ,medicine.medical_specialty ,Migraine Disorders ,Population ,Sensitivity and Specificity ,Young Adult ,03 medical and health sciences ,medicine ,Humans ,education ,Migraine ,Mass screening ,Chronic migraine ,business.industry ,lcsh:R ,Translating ,medicine.disease ,Health Surveys ,Neurology (clinical) ,Anesthesiology and Pain Medicine ,Clinical diagnosis ,Chronic Disease ,Physical therapy ,International Classification of Headache Disorders ,business ,030217 neurology & neurosurgery - Abstract
Background Case-finding tools, such as the Identify Chronic Migraine (ID-CM) questionnaire, can improve detection of CM and alleviate its significant societal burden. We aimed to develop and validate the Italian version of the ID-CM (ID-EC) in paper and as a smart app version in a headache clinic-based setting. Methods The study investigators translated and adapted to the Italian language the original ID-CM questionnaire (ID-EC) and further implemented it as a smart app. The ID-EC was tested in its paper and electronic version in consecutive patients referring to 9 Italian tertiary headache centers for their first in-person visit. The scoring algorithm of the ID-EC paper version was applied by the study investigators (case-finding) and by patients (self-diagnosis), while the smart app provided to patients automatically the diagnosis. Diagnostic accuracy of the ID-EC was assessed by matching the questionnaire results with the interview-based diagnoses performed by the headache specialists during the visit according to the criteria of International Classification of Headache Disorders, III edition, beta version. Results We enrolled 531 patients in the test of the paper version of ID-EC and 427 in the validation study of the smart app. According to the clinical diagnosis 209 patients had CM in the paper version study and 202 had CM in the smart app study. 79.5% of patients returned valid paper questionnaires, while 100% of patients returned valid and complete smart app questionnaires. The paper questionnaire had a 81.5% sensitivity and a 81.1% specificity for case-finding and a 30.7% sensitivity and 90.7% specificity for self-diagnosis, while the smart app had a 64.9% sensitivity and 90.2% specificity. Conclusions Our data suggest that the ID-EC, developed and validated in tertiary headache centers, is a valid case-finding tool for CM, with sensitivity and specificity values above 80% in paper form, while the ID-EC smart app is more useful to exclude CM diagnosis in case of a negative result. Further studies are warranted to assess the diagnostic accuracy of the ID-EC in general practice and population-based settings.
- Published
- 2019
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