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This study is devoted to a new research topic in real-time airline operations, the redispatching of unit load devices (ULDs) under demand variations. We develop a new hybrid framework to solve the problem of ULD redispatch following the time-sequence decision-making required by airlines. The hybrid framework is developed by integrating techniques including the probability distribution technique to simulate different types of operational demand, the adjustable number of stages which is needed to meet the requirements of a decision-making process following a time sequence and the time pressure characteristic of real operations, and the scenario tree and probability rule approaches which are aimed and representing all possible demand scenarios for a stage, while the network flow technique is applied to represent the movement and location of ULDs at each airport over time and is used for the development of the associated mathematical model and the simulation. We performed a simulation of 2,000 cases based on different operational days and types of operational demand. The results show that this hybrid framework is able to achieve stability and also a small variability of both ULD operating costs and solution times, which could allow the airline to save on ULD operating costs, under demand variations in real-time operations. [ABSTRACT FROM AUTHOR]