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1. Helicobacter pylori-induced matrix metallopeptidase-10 promotes gastric bacterial colonization and gastritis.

Author

Yi-pin Lv, Ping Cheng, Jin-yu Zhang, Fang-yuan Mao, Yong-sheng Teng, Yu-gang Liu, Hui Kong, Xiao-long Wu, Chuan-jie Hao, Bin Han, Qiang Ma, Shi-ming Yang, Weisan Chen, Liu-sheng Peng, Ting-ting Wang, Quan-ming Zou, and Yuan Zhuang

Subjects
*MATRIX metalloproteinases, *HELICOBACTER pylori infections, *GASTRITIS, *GASTRIC mucosa, *INTERLEUKIN-22, *CADHERINS, *TIGHT junctions
Abstract

The article looks at a study which demonstrate procolonization and proinflammation role of matrix metallopeptidase-10 (MMP-10) in Helicobacter pylori–induced gastric bacterial colonization and gastritis. It mentions MMP-10 is elevated in gastric mucosa and is produced by gastric epithelial cells synergistically induced by Helicobacter pylori and Interleukin-22 (IL-22) via the ERK pathway. It also mentions influence of MMP-10 decrease Reg3a, epithelial cadherin, and zonula occludens–1 proteins.

Published
2019
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