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Your search keyword '"G, Janaki"' showing total 2 results
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2 results on '"G, Janaki"'

1. Carcinoma esophagus with xeroderma pigmentosa: Case report on a rare association

Author

P Guru Sai Ratna Priya and M G Janaki

Subjects
xeroderma pigmentosa, Pathology, medicine.medical_specialty, Carcinoma esophagus, DNA damage, business.industry, medicine.medical_treatment, General Medicine, Base excision repair, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, lcsh:RC254-282, Radiation therapy, Non-homologous end joining, chemistry.chemical_compound, Oncology, chemistry, medicine, Radiology, Nuclear Medicine and imaging, External beam radiotherapy, business, Homologous recombination, DNA, radiotherapy, Nucleotide excision repair
Abstract

Radiation in patients with diseases such as xeroderma pigmentosa (XP), systemic lupus erythematosus, and other connective diseases is a matter of concern because of higher incidence of toxicities. Here with, we are reporting a case of carcinoma esophagus with XP, who tolerated the treatment well with sufficiently prolonged palliation of symptoms, after treatment with external beam radiotherapy. This might be attributed to the different mechanisms of DNA damage and repair mechanisms for ultraviolet (UV) rays and X-rays. UV rays cause DNA damage by dimer formation whereas X-rays will cause single- or double-stranded breaks in DNA. The repair mechanisms for UV rays are nucleotide excision repair and translesion synthesis while for X-rays, they are base excision repair, homologous recombination, and nonhomologous end joining, and these repair mechanisms for X-rays are intact in a XP patient. Hence, they can be been treated with high dose of radiation, and they do tolerate the treatment well.

Published
2018

2. Indian Brachytherapy Society Guidelines for radiotherapeutic management of cervical cancer with special emphasis on high-dose-rate brachytherapy.

Author

Mahantshetty, Umesh, Gudi, Shivakumar, Singh, Roshni, Sasidharan, Ajay, Sastri, Supriya (Chopra), Gurram, Lavanya, Sharma, Dayanand, Ganeshrajah, Selvaluxmy, M. G., Janaki, Badakh, Dinesh, Basu, Abhishek, James, Francis, Swamidas, Jamema V., Kuppuswamy, Thayalan, and Bhalavat, Rajendra

Subjects
CERVICAL cancer, RADIOISOTOPE brachytherapy, RADIOTHERAPY, PATIENT selection, HIGH dose rate brachytherapy
Abstract

Brachytherapy (BT) for locally advanced cervical cancer is vital for optimal outcomes. There is heterogeneity in brachytherapy treatment practice for cervical cancer across India. In an attempt to standardize various processes involved in cervical cancer brachytherapy, the expert members of the Indian Brachytherapy Society (IBS) developed a document related to radiation therapy treatment of cervical cancer with special emphasis on brachytherapy. The guidelines are based on high quality clinical evidence, expert opinion and consensus wherever evidence was lacking. The document provides a guide for external beam radiation and details of all the processes involved in high-dose-rate (HDR) brachytherapy including patient selection, preparation, principles and technique of BT applications, target and normal tissue definition, dose prescriptions, BT planning, reporting parameters, common complications of BT and their management, scope for research, etc. In summary, we present here practical tips and tricks, recording and reporting of cervical cancer brachytherapy, which can be implemented in various clinical environments and forms the basis of this report. [ABSTRACT FROM AUTHOR]

Published
2019
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