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This study investigated the effects of 5E instructional model on the teaching processes of novice teachers. First, we conducted a teaching design training project based on the 5E model for 40 novice teachers, and compared pre-texts of the teachers' teaching process from before the training with post-texts obtained immediately following the training to determine whether the model can promote the teaching design process of novice teachers. In order to explore how the 5E model influenced the novice teachers' teaching processes, we chose three teachers for an additional three stages of training, then compared the texts resulting from the different stages and interviewed each teacher. Finally, we found that the 5E model had a significant effect on the improvement and further development of the teaching processes among the novice teachers. The model influenced the teachers' teaching process through each of the sub-phases, and different sub-phases resulted in different improvements. Each novice teacher also showed different improvements, with the specific improvements also being affected by teachers' personal beliefs.

Autism spectrum disorders (ASD) is a group of heterogeneous neurodevelopmental disorders. Evidence has implied that environmental pollutants are important factors related to ASD. In this study, several environmental endocrine-disrupting chemicals, including parabens, benzophenone-type ultraviolet filters, hydroxyl polycyclic aromatic hydrocarbons, triclosan and tetrabromobisphenol A were analyzed in blood plasma in ASD children (n = 34) and the control children (n = 28). The results showed that parabens were the most concentrated chemicals (2.18 ng/mL, median value), followed by hydroxyl polycyclic aromatic hydrocarbons (0.73 ng/mL), benzophenone-type ultraviolet filters (0.14 ng/mL), triclosan (0.13 ng/mL) and tetrabromobisphenol A (0.03 ng/mL). ASD children accumulated significantly lower 2-hydroxy-4-methoxybenzophenone, 2,4-dihydroxybenzophenone, 4-hydroxybenzophenone and triclosan but higher 2-hydroxyphenanthrene and tetrabromobisphenol A than the control children (0.02/0.09 ng/mL of 2-hydroxy-4-methoxybenzophenone, p < 0.05; 0.04/0.07 ng/mL of 2,4-dihydroxybenzophenone, p < 0.05; 0.03/0.04 ng/mL of 4-hydroxybenzophenone, p < 0.05; 0.13/1.22 ng/mL of triclosan, p < 0.01; 0.03 ng/mL/not detected of 2-hydroxyphenanthrene, p < 0.05; 0.03/0.004 ng/mL of tetrabromobisphenol A, p < 0.05). Gender differences in certain environmental endocrine-disrupting chemicals were evident, and the differences were more inclined toward boys. Positive associations between 2-hydroxy-4-methoxybenzophenone and triclosan, and tetrabromobisphenol A and 2-hydroxyphenanthrene were found in ASD boys. Binary logistic regression analysis showed that the adjusted odds ratio value of 2-hydroxyphenanthrene in ASD boys was 11.0 (1.45–84.0, p < 0.05). This is the first pilot study on multiple environmental endocrine-disrupting chemicals in children with ASD in China. [ABSTRACT FROM AUTHOR]

Pharmaceuticals, such as over-the-counter (OTC) medicines, may be an important source of human exposure to several endocrine disruptors, though unnoticed to date. In the present study, we investigated the presence of six parabens and nine bisphenol A (BPA) and its analogues in OTC medicines manufactured in China. Parabens and bisphenols were present in more than 90% of the samples. The total measured concentrations of parabens and bisphenols were in the range of non-detectable (ND) to 213 ng/g and ND to 415 ng/g, respectively. Regarding parabens, methyl paraben (MeP) was the predominant analog, accounting for 43 ± 36% of the total amount, followed by ethyl paraben (EtP) (39 ± 35%), and others (< 10%). Bisphenol F and BPA were the predominant bisphenols, accounting for 24 ± 28% and 22 ± 26% of the total amount, respectively. The median values of estimated daily intakes (EDIs) of parabens and bisphenols were the highest for infants (2.96 and 3.14 ng/kg_bw/day, respectively) and the lowest for adults (0.69 and 0.25 ng/kg_bw/day, respectively); moreover, the EDIs of parabens and bisphenols were higher in Chinese patent medicines than in western pediatric medicines. The hazard quotient (HQ) for sum of MeP and EtP (∑(MeP + EtP)) and BPA in three age groups were within the safe zone (HQ < 0.0004). Monte Carlo simulation was applied to predict the human exposure risk of parabens and bisphenols. The predicted ranges of EDIs of parabens and bisphenols were much wider, and the extreme predicted values were observed in all four age groups, which were higher than the acceptable daily intake. The extreme predicted values of ∑(MeP + EtP) and BPA were indicative of carcinogenic risk in toddlers. These results implied potential risks for the Chinese people existed. Considering the huge export of Chinese traditional medicines and western medicines worldwide, and easy access to OTC medicines for the general population, the presence of parabens, bisphenols, and other environmental contaminants in medicines still need to be monitored. [ABSTRACT FROM AUTHOR]

Hexabromocyclododecane (HBCD) and tetrabromobisphenol A (TBBPA) are legacy brominated flame retardants which are still produced and used in China. In this study, 187 surface soils from the Pearl River Delta (PRD) urban conurbation in China were collected, and the effects of urban conurbation development on the concentrations, distributions and human exposure risk of HBCDs and TBBPA were investigated. The concentration ranges of Σ 3 HBCD (sum of α-, β-, and γ-HBCD) and TBBPA in soil were below the limit of quantification (−1 dry weight (dw) and < LOQ to 53.1 ng g−1 dw, respectively. Concentration levels of HBCDs and TBBPA in the PRD were affected both by distributions of land-use type and by the location of the city. Soils from residential areas contained the highest concentrations of Σ 3 HBCD (median: 1.75 ng g−1 dw) and TBBPA (1.92 ng g−1 dw) among all land-use types. In addition, soils from the central PRD had higher Σ 3 HBCD and TBBPA levels (0.46 and 0.90 ng g−1 dw) than those from the surrounding areas (0.17 and 0.07 ng g−1 dw). The concentrations of Σ 3 HBCD and TBBPA were highly correlated with urbanization level, population density, regional GDP and per capita income in all cities studied (p < 0.01), which indicates that the prosperity of the urban conurbation may play an important role in soil contamination of HBCDs and TBBPA in the PRD. Children living in residential areas had the highest estimated daily intakes of Σ 3 HBCD (7.09 pg kg−1 d−1) and TBBPA (7.76 pg kg−1 d−1), suggesting that people living in residential areas have a relatively higher exposure risk of HBCDs and TBBPA. This is a comprehensive study to report the effects of prosperity indices and land use indicators of an urban conurbation on the occurrence of HBCDs and TBBPA in soil in China. Image 1 • Conc. of HBCDs and TBBPA in soils were affected by land-use type and city location. • Urban prosperity may play an important role in soil contamination of HBCDs and TBBPA. • People living in the residential areas were exposure to relative higher levels of HBCDs and TBBPA, especially for children. Urban conurbation development affects contamination of HBCDs and TBBPA in soil. [ABSTRACT FROM AUTHOR]

Benzophenone (BP)-type UV filters are commonly used in our daily life. 2-hydroxy-4-methoxy benzophenone (BP-3), 4-hydroxy benzophenone (4-HBP), 2,4-dihydroxy benzophenone (BP-1), 2,2′,4,4′-tetrahydroxy benzophenone (BP-2) and 2,2′-dihydroxy-4-methoxy benzophenone (BP-8) were measured in urine samples from Chinese young adults. The results indicated that Chinese young adults were widely exposed to BP-3, BP-1, and 4-HBP, with the median concentrations of 0.55, 0.21, and 0.08 ng/mL, respectively. No significant difference was found between males and females, between urban and rural population. The correlations between urinary concentrations provided important indications for sources and metabolic pathways of target compounds. The estimated daily excretion doses of BP-3, 4-HBP, BP-1, BP-2 and BP-8 were 27.2, 2.24, 5.86, 0.76 and 0.30 ng/kg-bw/day, respectively. The ratio of exposure to excretion must be considered for the exposure assessment with chemicals based on urine measurement. This is the first nationwide study on BP-derivatives with young adults in China. [ABSTRACT FROM AUTHOR]

Energy consumption issues are important factors concerning the achievement of sustainable social development and also have a significant impact on energy security, particularly for China whose energy structure is experiencing a transformation. Construction of an accurate and reliable prediction model for the volatility changes in energy consumption can provide valuable reference information for policy makers of the government and for the energy industry. In view of this, a novel improved model is developed in this article by integrating the modified state transition algorithm (MSTA) with the Gaussian processes regression (GPR) approach for non-fossil energy consumption predictions for China at the end of the 13th Five-Year Project, in which the MSTA is utilized for effective optimization of hyper-parameters in GPR. Aiming for validating the superiority of MSTA, several comparisons are conducted on two well-known functions and the optimization results show the effectiveness of modification in the state transition algorithm (STA). Then, based on the latest statistical renewable energy consumption data, the MSTA-GPR model is utilized to generate consumption predictions for overall renewable energy and each single renewable energy source, including hydropower, wind, solar, geothermal, biomass and other energies, respectively. The forecasting results reveal that the proposed improved GPR can promote the forecasting ability of basic GPR and obtain the best prediction effect among all the other comparison models. Finally, combined with the forecasting results, the trend of each renewable energy source is analyzed. [ABSTRACT FROM AUTHOR]

The interconnection of multiple regional integrated energy systems (RIES) can effectively enhance the low-carbon and flexible operation capabilities of RIES, but the uncertainty and multi-energy interaction of the system pose challenges to the stable operation of RIES. Therefore, a stochastic hierarchical optimization and revenue allocation approach is proposed to optimize the operational strategy of multi-RIES with multi-operator participation, multi-energy interactions, and multiple uncertainties. Firstly, agent-based modeling, Latin hypercube sampling and simultaneous backward reduction based on the Wasserstein metric are proposed to capture the power-side and load-side uncertainties. Secondly, based on the Nash bargaining game and the alternating direction method of multipliers algorithm, multi-RIES peer-to-peer transactions of electricity, thermal, and natural gas are optimized through energy cooperation and scheduling strategies. Subsequently, a Nash-Harsanyi bargaining game revenue allocation method that considers both fairness and renewable energy accommodation is proposed to ensure the stable operation of the alliance. Finally, simulations are conducted on a multi-RIES in northern China, demonstrating that the proposed model and approach can achieve inter-grid flexible resource complementarity, improve RIES economics, increase local renewable energy accommodation rate, and reduce carbon emissions. • Multi-RIES multi-energy internal scheduling and P2P transaction co-optimization. • Wasserstein metric is introduced into the SBR model to capture stochastic scenarios. • A multi-RIES stochastic hierarchical optimization model based on cooperative games. • ADMM is used to solve distributed stochastic hierarchical optimization model. • A revenue allocation method considering equity & renewable energy development is proposed. [ABSTRACT FROM AUTHOR]

Background: Detection of IgG subclasses (IgGSc) is vital for the diagnosis and management of disease, especially IgG4-related diseases (IgG4-RD). This study aimed to evaluate the performances of the chemiluminescent immunoassay (CLIA) for detecting IgGSc and diagnosing IgG4-RD by IgGSc., Methods: A total of 40 individuals with IgG4-RD, 40 with primary Sjogren's syndrome (pSS), and 40 healthy controls (HCs) were enrolled. Serum samples were collected for the simultaneous detection of IgG1, IgG2, IgG3, and IgG4 by the Siemens immunonephelometric assay and the CLIA. The correlation analysis was performed, and diagnostic value was analyzed by the receiver operating characteristic (ROC) curve., Results: Patients with IgG4-RD had higher IgG4 (p < 0.001) and lower IgG1 (p < 0.001) than those with pSS, and HC. The results by the Siemens immunonephelometric assay and the CLIA showed a strong correlation in detecting IgG1, IgG2, IgG3, and IgG4 (r = 0.937, r = 0.847, r = 0.871, r = 0.990, all p < 0.001, respectively). The sum of IgG1, IgG2, IgG3, and IgG4 using two assays strongly correlated with total IgG by the IMMAGE 800 (r = 0.866, r = 0.811, both p < 0.001, respectively). For discriminating IgG4-RD from pSS and HC, no significant differences were observed in CLIA IgG4 and Siemens immunonephelometric assay IgG4 (z = 0.138, p = 0.891), which provided the area under the curves (AUCs) of 0.951 (p < 0.001) and 0.950 (p < 0.001), respectively. The AUCs of CLIA IgG1 and Siemens immunonephelometric assay IgG1 in distinguishing pSS from IgG4-RD and HC were 0.761 (p < 0.001) and 0.765 (p < 0.001), respectively, with no significant differences (z = 0.228, p = 0.820)., Conclusions: The CLIA and the Siemens immunonephelometric assay appeared to have good consistency with comparable diagnostic value in detecting IgGSc, especially IgG4, and IgG1 that can accurately identify IgG4-RD or pSS in clinical practice., (© 2024 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC.)

Phthalic acid esters (PAEs), a class of typical endocrine disruptors, have received considerable attention due to their widespread applications and adverse effects on biological health. In this study, 30 water samples, along the mainstream of the Yangtze River (YR), were collected from Chongqing (upper stream) to Shanghai (estuary) from May to June in 2019. The total concentrations of 16 targeted PAEs ranged from 0.437 to 20.5 μg/L, with an average of 1.93 μg/L, where dibutyl phthalate (DBP, 0.222-20.2 μg/L), bis (2-ethylhexyl) phthalate (DEHP, 0.254-7.03 μg/L), and diisobutyl phthalate (DIBP, 0.0645-0.621 μg/L) were the most abundant PAEs. According to the pollution level in the YR to assess the ecological risk posed by PAEs, the results showed medium risk level of PAEs in the YR, among which DBP and DEHP posed a high ecological risk to aquatic organisms. The optimal solution for DBP and DEHP is found in ten fitting curves. The PNEC SSD of them is 2.50 μg/L and 0.34 μg/L, respectively., (© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)

Objective: To guide clinical decision making, race-, age- and gender-specific reference ranges for lymphocytes and CD4+ T-cell subsets are required., Methods: Single platform flow cytometry to determine reference intervals for lymphocyte subpopulations and CD4+ T-cell subsets in 196 healthy Han Chinese adults., Results: The frequencies and absolute numbers of B cells were slightly lower in Han Chinese individuals of the Shanxi region than in individuals from Hong Kong, Germany and Singapore, while percentages and absolute numbers of NK cells were slightly higher compared with individuals from Hong Kong. CD4+/CD8+ T-cell ratios, CD4+ T cell percentages and Th2 cell counts were higher, while frequencies and numbers of CD8+ T cells, numbers of NK cells and percentages of Th1 cells were lower, in females compared with males. CD4+ T cell percentages, CD4+/CD8+ T-cell ratios, numbers of CD8+ T cells and Treg cells, and Th17/Treg cell ratios differed by age., Conclusion: We established lymphocyte and CD4+ T-cell subset reference intervals for healthy Han Chinese adults of the Shanxi region. Ethnicity, gender and age affected lymphocyte subset composition.

Phthalates have been associated with reproductive toxicity and precocious puberty in females, but the occurrence of these toxicants in feminine hygiene products is rarely reported. In this study, eight phthalates were determined in 120 feminine hygiene products (56 feminine care products and 64 sanitary napkins) collected from China. Phthalates were found in 86% and 98% of feminine care products and sanitary napkins, respectively, with the total concentrations varying between not detectable and 813 μg/g (median: 0.26 μg/g) and 0.25 and 8.76 μg/g (1.43 μg/g), respectively. Diethyl phthalate, dibutyl phthalate, and bis(2-ethylhexyl)phthalate were the major compounds, accounting for >60% of the total concentrations. The plastic materials used on the top and bottom layers and the hot melt adhesive used during the manufacturing process are the potential sources of phthalates in sanitary napkins. The range of daily exposure doses of phthalates in women from the use of feminine care products and sanitary napkins was <0.001-0.156 μg/kg-bw/day and <0.001-0.731 μg/kg-bw/day, respectively. Sanitary napkins contributed to 8.2% of the total exposure, and the levels of exposure to several phthalates from sanitary napkins were much higher than those reported from indoor dust ingestion but were lower than those of dietary intakes. Our study confirmed a new source of women's exposure to phthalates, sanitary napkins.

Environmental endocrine disruptors (EEDs) in beverages may enter the human body by ingestion and thus may represent a potential health risk. In this study, phthalates, bisphenol A, and its analogues, parabens, benzophenone-type UV filters, and triclosan (TCS) were analyzed in beverage samples (n = 116) collected from local markets in Guangzhou, South China. Twelve of 30 target compounds were found in > 50% samples, and for the first time, TCS was found in a majority of beverages from China (~ 80%). Among all analytes, concentrations of total phthalates (median = 14.4 ng/mL) were generally two orders of magnitude higher than other target EEDs, and concentrations of total benzophenone-type UV filters (0.02 ng/mL) and TCS (0.01 ng/mL) were the lowest. Among all targets, phthalates were predominant, accounting for > 99% of the total EEDs, and dimethyl phthalate was frequently detected in beverages (> 60%). In addition, we estimated the daily intake (EDI) of EEDs for Chinese populations of different age groups based on the daily consumption of beverages. The EDIs of total EEDs were the highest for toddlers (mean = 14,200 ng/kg-bw/day) followed by children and teenagers (3420 ng/kg-bw/day), adults (1950 ng/kg-bw/day), the elderly (1740 ng/kg-bw/day), and infants (70 ng/kg-bw/day). Compared to all food categories, EEDs from beverage consumption accounted for ~ 0.1% (parabens) to 20% (phthalates) of total exposure from diet. However, intakes of phthalates, bisphenols, and TCS from beverages were comparable to those from other potential sources (food, dust, personal care products, cloth, and medicines). Furthermore, the cumulative risks of EEDs by beverage consumption were not high, which indicated that EEDs in beverages might not represent a potential human health risk for Chinese populations.

Triclosan (TCS) is an endocrine disruptor which may affect endocrine function, antibiotic resistance, and thyroid hormone homeostasis. As a broad-spectrum antimicrobial agent used in medical and personal care products, TCS was frequently detected in human urine, indicating widespread human exposure to this chemical. Over-the-counter medicines (OTCs) may be a potential source of human exposure to TCS. In this study, 84 OTCs were collected from Guangzhou, South China, including medicines intended for both children and adults. We determined the concentration of TCS in OTCs and the estimated daily intakes (EDIs) of TCS by evaluating OTCs for different age groups of the Chinese population. Our results indicated over half of the evaluated medicines contained TCS and the highest concentration reached 7.825 ng/g, with a median value of 0.017 ng/g. TCS was frequently found in adult medicines (detected in 85% of samples), and the concentrations were significantly higher than those in children's medicines. TCS in OTCs may come from packaging materials, cultivated soils, or production process (Chinese patent medicines). The EDIs of TCS (estimated with 95th concentration in OTC medicines) were 0.305, 0.191, 0.287, 0.331, and 0.135 and 0.110 ng/kg-bw/day for infants, toddlers, children, teenagers, and adult females and males, respectively. Compared to other potential sources, human exposure to TCS from OTCs was limited in China-much less than TCS exposure through personal care products or indoor dust.

Phthalates are widely used in consumer products. People are frequently exposed to phthalates due to their applications in daily life. In this study, 14 phthalate metabolites were analyzed in 108 urine samples collected from Chinese young adults using high-performance liquid chromatography-tandem mass spectrometry. The total concentrations of 14 phthalate metabolites ranged from 71.3 to 2670 ng/mL, with the geometric mean concentration of 306 ng/mL. mBP and miBP were the two most abundant compounds, accounting for 48% of the total concentrations. Principal component analysis suggested two major sources of phthalates: one dominated by the DEHP metabolites and one by the group of mCPP, mBP and miBP metabolites. The estimated daily intakes of DMP, DEP, DBP, DiBP and DEHP were 1.68, 2.14, 4.12, 3.52 and 1.26-2.98 μg/kg-bw/day, respectively. In a sensitivity analysis, urinary concentration and body weight were the most influential variables for human exposure estimation. Furthermore, cumulative risk for hazard quotient (HQ) and hazard index (HI) were evaluated. Nearly half of Chinese young adults had high HI values exceeding the safe threshold. This is the first study on the occurrence and human exposure to urinary phthalate metabolites with Chinese young adults., (Copyright © 2015 Elsevier B.V. All rights reserved.)