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Background and Objective: Knee osteoarthritis(KOA) is a chronic degenerative disease characterized by pain, morning stiffness and swelling in the knee joints. And KOA is common in the elderly and seriously affects the exercise function and physical health of patients. This study aimed to explore the curative effects of patellar inward pushing method(PIPM) on KOA. Methods: In this study, we established rabbit animal models of KOA for the research by using the New Zealand white rabbits. A total of n=30 rabbits were divided into 5 groups by random number table method: blank group, model group, glucosamine hydrochloride(GH) group, PIPM group and PIPM combined with GH group. The rabbits were then modeled. Results: After 9-weeks cultured in groups, 5 ml blood was collected from the heart, and cytokines were detected. The result suggested that iNOS, NO and TNF-α were the pathogenic inflammatory factor of KOA, and aggravated cartilage damage and degeneration. Besides, this study indicated that PIPM combined with GH treatment significantly reduced the activity of inflammatory cytokines in serum and joint fluid of KOA model in rabbits. In addition, PIPM combined with GH therapy exhibited the best therapeutic effect among these treatments, which was working on KOA better than PIPM treatment alone or GH treatment alone. Conclusion: PIPM could effectively treat KOA via regulating cytokines, and the PIPM combined with GH therapy could be a novel therapeutic strategy for KOA. [ABSTRACT FROM AUTHOR]

The distribution of slip during an earthquake and how it propagates among faults in the subduction system play a major role in seismic and tsunami hazards, yet they are poorly understood because offshore observations are often lacking. Here we derive the slip distribution and rupture evolution during the 2016 M w 7.9 Kaikōura (New Zealand) earthquake that reconcile the surface rupture, space geodetic measurements, seismological and tsunami waveform records. We use twelve fault segments, with eleven in the crust and one on the megathrust interface, to model the geodetic data and match the major features of the complex surface ruptures. Our modeling result indicates that a large portion of the moment is distributed on the subduction interface, making a significant contribution to the far field surface deformation and teleseismic body waves. The inclusion of local strong motion and teleseismic waveform data in the joint inversion reveals a unilateral rupture towards northeast with a relatively low averaged rupture speed of ∼1.5 km/s. The first 30 s of the rupture took place on the crustal faults with oblique slip motion and jumped between fault segments that have large differences in strike and dip. The peak moment release occurred at ∼65 s, corresponding to simultaneous rupture of both plate interface and the overlying splay faults with rake angle changes progressively from thrust to strike-slip. The slip on the Papatea fault produced more than 2 m of offshore uplift, making a major contribution to the tsunami at the Kaikōura station, while the northeastern end of the rupture can explain the main features at the Wellington station. Our inversions and simulations illuminate complex up-dip rupture behavior that should be taken into consideration in both seismic and tsunami hazard assessment. The extreme complex rupture behavior also brings new challenges to the earthquake dynamic simulations and understanding the physics of earthquakes. [ABSTRACT FROM AUTHOR]