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Purpose: Peripheral neuropathy is a dose-limiting adverse effect of oxaliplatin. The aim of this study was to evaluate the efficacy and safety of duloxetine in the prevention of oxaliplatin-induced peripheral neuropathy (OIPN). Method: Cancer patients receiving oxaliplatin based chemotherapy were randomized into two arms. Duloxetine 60 mg capsule was given in the first 14 days of each chemotherapy cycle to one arm and placebo was similarly given to another. We compared the two arms based on the incidence of neuropathy and the results of the nerve conduction study (NCS). Grade of complained neuropathy was recorded according to Common Terminology Criteria for Adverse Events (CTCAE). Results: Thirty-two patients mostly rectal cancer (90.6%) were randomized to duloxetine and placebo arms. Highest grade of neuropathy in each cycle was not significantly different between the two groups. Six weeks after treatment incidence of neuropathy of any grade was 52.9 in duloxetine arm compared to 76.9% in placebo arm (P: 0.26). Patients in the duloxetine arm had a lower percentage of chemotherapy cycles (mean) in which they reported distal paresthesia (51% vs. 84%, P = 0.01) and throat discomfort (37% vs. 69%, P = 0.01). Results of NCS were mostly comparable between the two arms except for the velocity in two of the examined nerve which was significantly higher in duloxetine group. Duloxetine was safe and well-tolerated. Conclusion: Although a definite conclusion might be difficult to draw but administering duloxetine for 14 days in each chemotherapy cycle could not decrease the incidence of acute OIPN based on CTCAE grading system. [ABSTRACT FROM AUTHOR]

Introduction: The present study aimed to investigate the interaction of the common lncRNA-miRNA-mRNA network involved in signaling pathways in different stages of prostate cancer (PCa) by using bioinformatics and experimental methods. Methods: Seventy subjects included sixty PCa patients in Local, Locally Advanced, Biochemical Relapse, Metastatic, and Benign stages, and ten healthy subjects were entered into the current study. The mRNAs with significant expression differences were first found using the GEO database. The candidate hub genes were then identified by analyzing Cytohubba and MCODE software. Cytoscape, GO Term, and KEGG software determined hub genes and critical pathways. The expression of candidate lncRNAs, miRNAs, and mRNAs was then assessed using Real-Time PCR and ELISA techniques. Results: 4 lncRNAs, 5 miRNAs, and 15 common target genes were detected in PCa patients compared with the healthy group. Unlike the tumor suppressors, the expression levels of common onco-lncRNAs, oncomiRNAs, and oncogenes showed a considerable increase in patients with advanced stages; Biochemical Relapse and Metastatic, in comparison to the primary stages; Local and Locally Advanced. Additionally, their expression levels significantly increased with a higher Gleason score than a lower one. Conclusion: Identifying a common lncRNA-miRNA-mRNA network associated with prostate cancer may be clinically valuable as potential predictive biomarkers. They can also serve as novel therapeutic targets for PCa patients. [ABSTRACT FROM AUTHOR]

Comparative studies, in addition to showing the overlap between culture and literature, can lead to the identification of national literature as much as possible and reveal the position of each work in comparison with its international examples; therefore, such studies can play a significant role in the globalization of literature and identifying the strengths and weaknesses of local works. One of the approaches that can be used for the comparative study of two works is the narratological approach. In this approach, the narrative elements of two works are measured together and the similarities and differences are determined. Various theories have been proposed in the field of narratology. One of the most important theories in this regard belongs to the French theorist Gerard Genet (1930). He considers the "story" or the main plot of the story to be one of the aspects of the narrative and considers it to be the real sequence of events One of the approaches that can be used for the comparative study of two works is the narratological approach. In this approach, the narrative elements of two works are measured together and the similarities and differences are determined. Various theories have been proposed in the field of narratology. One of the most important theories in this regard belongs to the French theorist Gerard Genet (1930). He considers the "story" or the main plot of the story to be one of the aspects of the narrative and considers it to be the real sequence of events. In this research, a comparative comparison of one of the narrative elements (grammatical Tense) in two novels, "Don Quixote" and "Dayi Jan Napoleon", has been done. Tense is one of the elements that gives identity to narrative and story and is defined by three components of order, continuity and frequency. [ABSTRACT FROM AUTHOR]

Muscular stomach or gizzard is one of the most important parts of gastrointestinal tract in birds for mechanical and chemical digestion and can vary depending on the bird's eating habits. In the present study, the morphology of muscular stomach in common kestrel, steppe eagle, golden eagle and imperial eagle has been investigated and compared. Materials & Methods: In this study, common kestrel (n=4), steppe eagle (n=5), golden eagle (n=4) and imperial eagle (n=6) which died because of broken leg and wing, sent to the faculty of veterinary science at Bu-Ali Sina University of Hamadan. The gizzard samples were fixed in 10% formalin buffer solution and the histological process was carried. Finally, H&E, Masson's trichrome, Orcein and PAS staining were utilized. Results: The most important difference between the stomach of steppe, golden, and imperial eagles and common kestrel was the lack of keratinous layer in the surface of stomach in eagles. The histological structure of stomach in imperial eagle was more similar to that of steppe eagle. The differences of the stomach of imperial eagle were due to the presence of a thick muscle layer in several different rows with different directions in comparison with steppe and golden eagles. Conclusions: It can be concluded that, the structure of muscular stomach in common kestrel was similar to gizzard, while the stomach in three species of eagles did not have a keratinous layer. [ABSTRACT FROM AUTHOR]

Background and Objectives: The non-surgical treatment outcome of gastroesophageal junction (GEJ) adenocarcinoma remains to be defined. We aimed to assess the outcomes of definitive chemoradiation (CRT) of GEJ tumors. Methods: This retrospective cohort study was entirely carried out in the radiation oncology ward of Cancer Institute of Iran. We included patients with adenocarcinoma histology whose tumors had involved the gastro-esophageal junction and underwent chemoradiotherapy without surgery. In the final analysis, we evaluated 50 patients with non-metastatic adenocarcinoma of GEJ (Siewert's type I and II) from 2008 to 2017. The primary outcome was overall survival; secondary outcomes were progression-free survival and local and distal metastasis. Results: The reasons for not undergoing surgery in order of frequency from highest to lowest were patient refusal or medical unfitness for surgery, tumor unresectability or progress at the time of operation and incident metastasis in pre-op restaging, and. The 1-year, 2-year, and 3-year overall survival rates were 53%, 26%, and 12%, respectively. The 1-year, 2-year, and 3-year progression-free survival rates were 44%, 18%, and 10%, respectively. In the multivariate analysis, the only independent predictor of survival was a distant failure (P=0.031). Conclusion: Although the outcomes of non-surgical treatments are disappointing in GEJ adenocarcinomas, a few patients may experience long-term survival using definitive CRT. This option should be discussed with all patients who are not candidates for surgery. [ABSTRACT FROM AUTHOR]

Background: One of the most important fundamental issues in mental health is patients' satisfaction with the beauty of their teeth and their compatibility with complete dentures. Therefore, this study investigated the role of early maladaptive schemas and body image in the level of satisfaction with complete dentures among patients referred to the dental clinic of Islamic Azad University of Tabriz, Iran, in 2021-2022. Methods: The research was a descriptive correlational study. This study's statistical population included all candidates for complete dentures referring to the dental clinic of Islamic Azad University of Tabriz in 2021-22, from among which, 168 people were selected through convenience sampling method. The research tools included the Young Schema Questionnaire-Short Form (YSQ-SF) (1988), Body Image Concern Inventory (BICI) Littleton et al. (2005), and Dental Satisfaction Questionnaire (DSQ) by Davies and Ware (1982). The collected data were analyzed using multiple regression tests in SPSS software. Results: The results showed a relationship between the components of early maladaptive schemas [failure (B = -0.225), defectiveness/shame (B = -0.279), social isolation/alienation (B = 0.278), abandonment/instability (B = 0.331), subjugation (B = -0.264), and dependence/incompetence (B = 0.246)] and the level of satisfaction with complete dentures among the patients (P < 0.05). The results also showed a significant relationship between the components of body image and the level of satisfaction with complete dentures (P < 0.05). Conclusion: It can be concluded that early maladaptive schemas and body image playa role in the satisfaction level of patients referred to the dental clinic of Islamic Azad University of Tabriz. [ABSTRACT FROM AUTHOR]

Most histotechnical methods and preparation of tissue sections were invented and used in the 18th and 19th centuries. Due to the colorless nature of most cells and tissues in the body, tissue staining methods were used from the beginning to differentiate cells and tissues. Materials & Methods: According to sources and reports in this field, the time required for each hematoxylin-eosin staining period is approximately 80 minutes. In the present study, a method of hematoxylin-eosin staining is reported that reduces the time required for staining by maintaining the quality of sections and staining from 80 minutes to less than 40 minutes. Also, considering the existing problems regarding the cost of histochemistry and immunohistochemistry kits, the Low amount of kits and the problems that exist in the drip staining method of this type of staining, the present report tries to present three creative methods in this regard. These methods increase the quality of the prepared slides, in addition to reducing consumables. Optimization of tissue staining steps can reduce expenses spent and increase the quality of tissue sections. [ABSTRACT FROM AUTHOR]