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Background/aim Ganglioside antibodies are identified not only in patients with inflammatory neuropathies but also several central nervous system disorders and paraneoplastic neuropathies. Our aim was to investigate whether ganglioside antibodies are found in autoimmune encephalitis patients and may function as a diagnostic and prognostic biomarker. Materials and methods Sera and cerebrospinal fluid (CSF) samples of 33 patients fulfilling the criteria for probable autoimmune encephalitis were collected within the first week of clinical manifestation. None of the patients had evident symptoms and findings of peripheral polyneuropathy. Well-characterized anti-neuronal and paraneoplastic antibodies were investigated in sera and CSF and anti-ganglioside (anti-GM1, GM2, GM3, GD1a, GD1b, GT1b and GQ1b) IgG and IgM antibodies were measured in sera using commercial immunoblots. Results Twenty-eight of 33 autoimmune encephalitis patients displayed antibodies against neuronal surface or onco-neural antigens with N-methyl-D-aspartate receptor (NMDAR), glutamic acid decarboxylase (GAD) and Hu antibodies being the most prevalent. While no anti-ganglioside IgG antibodies were found, 4 patients (2 anti-NMDAR+, 1 anti-GAD+ and 1 antibody negative) with autoimmune limbic encephalitis displayed anti-GM1, anti-GM2, anti-GM3 or anti-GQ1b IgM antibodies. There was no apparent association between anti-ganglioside positivity and clinical and demographic features. Conclusion Serum ganglioside IgM antibodies may infrequently emerge during the clinical course of autoimmune limbic encephalitis without evident polyneuropathy. Absence of the IgG response suggests that these antibodies might have developed as a hyperacute immune response to neuro-axonal destruction. Nevertheless, potential impact of ganglioside antibodies on axonal degeneration and neuronal loss in limbic encephalitis pends to be further investigated.

This paper studies the radionuclide (

A Pulsed Electrical Field (PEF) reactor was developed to process biological sludge as a pretreatment method prior to anaerobic digestion. This study focuses on the effects of operational parameters such as applied voltage, pH, conductivity, flow-rate, and temperature affecting the treatment of waste active sludge (WAS) by PEF, the simulation of reactor process conditions and anaerobic biodegradation of PEF pretreated sludge. The effects of the sludge conductivity, flow-rate, and temperature on the Soluble Chemical Oxygen Demand (SCOD) of WAS treated by PEF reactor were investigated by using a Box-Wilson statistical experiment design. Simulations of the PEF process conditions were performed to verify experimental results. After PEF optimization study, the PEF operational conditions for maximum SCOD were obtained at 4 mS/cm conductivity, 5 mL/min flow-rate, and 40 degrees C temperature during PEF treatment. The measured and predicted SCOD showed a good consistency (R (2 )= 0.92). After it was pretreated by the PEF, the SCOD, total nitrogen, total phosphorus, polysaccharide and protein contents of WAS increased. However filterability property also decreased. In the anaerobic digestion study, the reactor fed with the PEF pretreated WAS provided 1.70 times higher methane production compared with raw sludge. In addition to this situation, 18% and 19% improvements, respectively, were observed in SCOD and VSS reductions when it was compared with raw sludge in the 23 days of anaerobic operation. Sixteen percent decrease in CST showed that the PEF enhanced the ?lterability of WAS during the anaerobic stabilization.

In this paper, nutrient recovery from sewage sludge as struvite using pulsed electric field (PEF) technique was performed. Box-Behnken response surface methodology (BBD) was used to determine the best struvite formation conditions. NH4-N removal efficiency (Y-1) and PO4-P removal efficiency (Y-2) were considered response functions, while the pH (X-1), magnesium concentration (X-2, mM), and phosphate concentration (X-3, mM) were considered independent variables in the BBD. The best struvite formation conditions by using BBD optimization was found for pH 8.5 and Mg+2/NH4+/PO4- molar ratio of 1.2:1:1.2 at 89.83% NH4-N and 80.30% PO4-P removal efficiency. The predicted dates for response functions determined by regression analysis exhibited excellent agreement with the experimental results. The obtained precipitation contained 61.7% struvite (MgNH4PO4 center dot 6H(2)O) and 38.3% nahpoite (Na2HPO4). The goodness of fit (GOF) was found as 1.67 and Bragg factor was calculated as 47.4% for this match in Rietveld refinement. Ammonia loss was calculated as 13% at optimum operation conditions using Visual Minteq. Saturation index (SI) value calculated by Visual Minteq was above zero, which means that the struvite can occur to the liquid phase of sludge pre-treated by PEF. After PEF pre-treatment, the heavy metals in liquid phase of WAS were below detection limit, except Cr and Ni. In study in evaluation of the obtained struvite, the heavy metal contents of the sediment were founded below the limit value, except Cr.

Biyolojikarıtma çamurları organik madde, azot ve fosfor içeriği yönünden zengin birkaynaktır. Bu nedenle tarımda kullanımı oldukça önemlidir. Magnezyum amonyumfosfat (MAP) çöktürmesi sonucu elde edilen strüvit, endüstriyel hammadde vetarımsal gübre olarak kullanım için uygundur. Arıtma çamurlarından azot vefosfor geri kazanımı için kullanılan yöntemlerin başında asidik şartlarda azotve fosforun sıvı faza geçirilmesi gelmekte ve akabinde MAP çökelmesi ilestrüvit elde edilmesi sağlanmaktadır. Bu yöntem için en büyük sorunasidifikasyon işlemi ile sıvı faza geçen ağır metallarin strüvitebağlanmasıdır. Çalışmamızda yeni bir çamur dezentegrasyon yöntemi darbelielektrik alan (PEF) tekniği ile evsel nitelikteki biyolojik atık çamurdan azotve fosfor geri kazanımı gerçekleştirilmiştir. Çalışma iki aşamadanoluşmaktadır. Birinci aşama; biyolojik atık çamurdaki azot ve fosforun kimyasaleklemeden PEF tekniği ile geri kazanımı. İkinci aşama ise PEF ön arıtımısonrası sıvı fazda elde edilen yüksek azot ve fosfordan MAP çöktürmesi ilestrüvit elde edilmesi şeklindedir. MAP çökeltim testlerinde optimum sıcaklık,pH ve çökelme süresi sırasıyla 20 °C, 9.5 ve 24 saat olarak belirlenmiştir. Eniyi çökelme ve giderim verimi 2.5 ml MgCl2.6H2O (0.015 M)ve 2.5 ml H3PO4 (0.049M) eklenmiş örnekte elde edildi.Çökeltim sonrası TN ve TP giderim verimleri sırasıyla %52 ve %14’tür. Çökeltimsonrası kristal yapılı çökelti oluşumu gözlenmiş ve XRD analizi sonucunda buçökeltinin strüvit olduğu tespit edilmiştir., Sewagesludge is a rich source of organic matter, nitrogen and phosphorus content. Forthis reason, its use in agriculture is very important. Strüvite obtained as aresult of magnesium ammonium phosphate (MAP) settlement is suitable for use asindustrial raw material and agricultural fertilizer. At the beginning of themethods used for the recovery of nitrogen and phosphorus from sludge, nitrogenand phosphorus are introduced into liquid phase under acidic conditions. Thenthe struvite is obtained by MAP precipitation. The biggest problem for this method is the bonding ofheavy metals passing liquid phase by acidification to struvite. In our work, a new sludge disintegration method,pulsed electric field (PEF) technique, has been used to recover nitrogen andphosphorus from the domestic biological waste sludge. The study consists of twophases. In the first stage, nitrogenand phosphorus from biological waste sludge are recovered without the additionof chemical by PEF technique. Inthe second stage, the strüvite is obtained by MAP precipitation from liquidphase with high nitrogen and phosphore content. The optimumtemperature, pH and precipitation time were determined as 20 °C, 9.5 and 24 hours, respectively for the formation of strüvite in the MAP precipitation tests. Thebest precipitate and removal efficiency was obtained to the sample with 2.5 mlof MgCl2.6H2O (0.015 M) and 2.5 ml of H3PO4(0.049M). TN and TP removal efficiencies were obtained as 52% and 14% afterprecipitation. After sedimentation, crystalline precipitate formation wasobserved and XRD analysis revealed that this precipitate was struvite.

In order to evaluate the radiological baseline in the Lake Van basin, U-238, Th-232,, Ra-226 Cs-137 and K-40 activity concentrations and gross radioactivity were determined in twelve river water and sediment samples. To determine radionuclide activities and gross radioactivity, a gamma ray spectrometer with HPGe detector and a gross-alpha/beta-counting system low background multi-detector were used, respectively. Therefore, based on the measured activity concentrations,. parameters of radiological hazards such as radium equivalent activity, outdoor absorbed dose rate, annual effective dose, and internal and external hazard indices were calculated. R-eq, H-ex and H-in and values in samples were generally lower than worldwide average values; while D-out, and AED values were higher than worldwide average values in general.

In the current work, the effect of the poly(2-aminoethyl methacrylate)-grafted kaolin (PAEMA@KLN) was investigated for the potential removal of U(VI) from aqueous samples. This novel adsorbent prepared for U(VI) removal was characterized by various techniques (Fourier transform infrared spectrometry (FTIR), energy-dispersive x-ray analysis (EDX), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS)). Response surface methodology (RSM) was utilized to optimize and model the removal of U(VI) by PAEMA@KLN from aqueous environments. The effects of different parameters such as pH, U(VI) concentration ( C o ), PAEMA@KLN dosage, and shaking time were optimized by central composite design (CCD) combined with RSM. The optimum points were numerically determined as 5.07 for pH, 35.16 mg/L for C o , 13.73 mg for PAEMA@KLN dosage, and 92.09 min for the shaking time. The maximum removal was obtained at 96.03% under the optimum conditions. The kinetic data was better described by the pseudo-second-order and Weber–Morris models. U(VI) removal onto PAEMA@KLN follows the Langmuir isotherm model. Thermodynamic studies showed that U(VI) removal by PAEMA@KLN was spontaneous and exothermic in nature. The results indicate that PAEMA@KLN is a promising adsorbent for the effective removal of radionuclides like U(VI) from aqueous media.

Treatability of Olive Mill Wastewater (OMW) by Pulsed High Voltage Discharge (PHVD) reactor using pure oxygen or air was investigated. It was shown that OMW was effectively treated through the combined reactions of the hydroxyl radicals, ultraviyole and ozone formed by applying pulsed electrical discharges in the presence of pure oxygen or air. The results show that PHVD using oxygen displays better performance than PHVD using air. PHVD process using pure oxygen removed 75 % of chemical oxygen demand (COD), 61 % of total organic carbone (TOC), 71 % of phenol and 76 % of color in OMW in 60 min under optimum conditions (pH = 10,temperature = 13 °C, conductivity = 30 mS/cm, voltage = 24 kV, flow rate = 7.5 mL/min.). Oxidation kinetic results showed that the both two oxidation processes behave as a pseudo-second-order reaction with respect to COD and phenol removal. When they are compared in terms of the operational costs, the operational cost of PHVD reactor using Air was lower than the cost of PHVD reactor using oxygen.

This study deals with radioactivity and heavy metal distribution and statistical analyses in the Bendimahi River Basin, which is within the Lake Van Closed Basin, Turkey. In order to identify the relationships between measured variables and to categorize soils and sediments collected at 15 sites on Bendimahi River, factor and cluster analysis have been applied. The data set is constituted of 9 radiological and physico–chemical variables, including gross alpha and gross beta activities and Pb, Zn, Cu, Cr, Cd, Co and Mn concentrations. Factor and cluster analysis were used to describe the relationship and similarity among data sets (variables) for the Bendimahi River. The convergence diagnostics such as trace plot and kernel density were applied to determine the convergence criteria to the data sets.

In this study, the performance of modified adsorbents obtained from activated carbon for the adsorption of thorium(IV) ions from aqueous media was investigated. The analytical and spectroscopic methods such as FT-IR, BET, SEM and UV-Vis were used to examine the properties of the modified materials. According to the analysis results, the both adsorbents had large surface areas after modification. Then, temperature, pH, mixing time and solution concentration parameters were observed to determine optimum thorium adsorption conditions on modified materials. The obtained results from the experiments were applied different three kinetic models and adsorption isotherms and thermodynamic parameters were calculated and then all of the results were interpreted. The adsorption process for both adsorption systems was observed to be compatible with the pseudo-second-order kinetic model. The adsorption equilibrium data were best described by the Langmuir model for modified adsorbent with KMnO4 and by the Freundlich model for modified adsorbent with NaOH. Furthermore, the calculated thermodynamic parameters (Delta G degrees, Delta H degrees and Delta S degrees) showed that the both adsorption processes were endothermic and spontaneous. The data show that modified adsorbents can be used as influential and low-cost adsorbents to remove thorium ion. Modified new adsorbents were highly selective for thorium ion in competitive adsorption studies.

Uranyum kirliligi yuksek toksisite ve radyoaktivite icerir. Bu nedenle insan sagligi ve cevre icin ciddi bir tehdit olusturur. Bu nedenle sulu cozeltilerden uranyumun geri kazanimi icin kimyasal cokeltme, iyon degisimi, ters ozmoz ve adsorpsiyon gibi bir dizi teknik gelistirilmistir. Dusuk konsantrasyonlarda, sulu cozeltilerden uranyum gibi uzun omurlu radyonuklidlerin adsorpsiyon yoluyla ayrilmasi hem nukleer/radyasyon kimyasinda hem de cevre/atik islem kimyasinda onemlidir. Cevre kirliliginin onlenmesi konusunda ekonomik ve teknik bakimlardan uygulanabilir yontemlere ihtiyac duyulmasi nedeniyle, dogal ve sentetik adsorbanlar uzerinde bircok calisma yapilmaktadir. Amidoksim gruplari iceren polimerlerin agir metal iyonlari iceren kompleksler olusturma egiliminde oldugu ve uranyum iyonlari iceren komplekslerin de oldukca cok arastirildigi belirlenmistir. Bu calismada sulu cozeltilerden uranyumun giderilmesi amaciyla amidoksim gruplari iceren yeni bir polimer adsorban madde uretilmistir. N-(3,4-disiyanofenil) akrilamid monomerini sentezlemek icin 4-aminoftalonitril ve akriloil klorur kullanildi ve bu monomer poli [N-(3,4-disiyanofenil) akrilamid]’e polimerize edildi. Son olarak, polimer nitril gruplari iceren amidoksimatlanmis forma donusturuldu. Monomer, polimer ve amidoksimatlanmis formunun yapisi, FT-IR spektroskopisi ve termal analiz yontemleri ile karakterize edildi. Temas suresi, pH, ilk konsantrasyon ve amidoksimatli polimer tarafindan U(VI) adsorpsiyonu uzerindeki sicaklik gibi cesitli deneysel parametrelerin etkisi arastirilmis ve uranyumun sulu cozeltiden adsorpsiyonu icin kosullar belirlenmistir. Kinetik kosullar icin, veriler sozde birinci derece, sozde ikinci derece ve partikul ici kinetik modeline uygulandi. Sonuclar, U(VI) 'nin amidoksimatlanmis polimer uzerindeki adsorpsiyonunun sozde ikinci dereceden kinetik modeline uydugunu gostermistir. Denge kosullari icin sulu cozeltilerdeki denge verileri Langmuir, Freundlich, Temkin ve Dubinin-Radushkevich gibi farkli sorpsiyon izotermlerine uygulandi. Adsorpsiyon denge verilerinin, U(VI) iyonlarinin amidoksimasyonlu polimer tarafindan adsorpsiyonunda Langmuir modeline cok uyum gosterdigi ve maksimum adsorpsiyon kapasitesinin 175.4 mg/g oldugu belirlenmistir. Termodinamik kosullar icin, ΔHo, ΔSo ve ΔGo termodinamik parametreleri hesaplandi ve degerlendirildi. ΔGo (-2.92 kJ/mol) negatif degeri, spontanligi belirtirken, ΔHo (15.14 J/mol) pozitif degeri, amidoksimasyonlu polimer tarafindan U(VI) adsorpsiyonu icin adsorpsiyon isleminin endotermik yapisini gostermektedir.00

It is becoming more and more critical to identify and eliminate pesticide residues that are intended to be used in combating agriculture but pose a threat to all living things due to their unconscious use. In this study, a high- performance molecular imprinted material (MIP) was synthesized to remove ziram, a dithiocarbamate fungicide, from its liquid phase. After characterization studies of the printed polymer synthesized by the suspension poly- merization process, the re-bonding ability and the suitability of the adsorption process to kinetic and isothermal models were compared with an non-imprinted reference polymer (NIP). Selectivity of MIP adsorbent prepared by imprinting method against template molecule ziram; their adsorption ability against different dithiocarbamate fungicides (maneb, ferbam, and propineb) was determined by testing. Some extraction parameters were opti- mized to evaluate the extraction performance of MIPs used as adsorbents in the solid-phase extraction column. It has been found that under optimized conditions, the developed MIP-SPE method provides high recovery for ziram. This method was developed; it was determined that MIP-SPE showed higher extraction efficiency against ziram than commercial C18-SPE and non-print polymer solid-phase extraction (NIP-SPE) processes. Thus, the MIP-SPE method has proven to be an environmentally friendly, sensitive, easy-to-work, time-saving, efficient sample pretreatment method that uses less solvent. These findings will provide a fundamentally technical for the removal of the trace hazardous pollutants.

© 2020 Elsevier B.V.UTSA-76 encoded MOF structure containing Lewis basic groups was efficiently synthesized and characterized for the removal of UVI from the liquid phase by using adsorption technique. 1H, 13C-NMR, FT-IR, P-XRD, TEM, TEM-EDX, BET, SEM and SEM-EDX mapping techniques were applied to define this adsorbent material. Adsorption of UVI on the synthesized UTSA-76 structure was investigated depending on the parameters of pH, temperature, mixing time and solution concentrations. In the kinetic of adsorption process, not only the pseudo-second-order kinetic, but also film diffusion was effective. The adsorption equilibrium of UVI on UTSA-76 explained better by Langmuir isotherm model and the qmax from Langmuir isotherm was calculated as 91.31 mg/g. The synthesized MOF structure (UTSA-76) demonstrated a removal rate from 12 ppm to 0.25 ppm in 45 min to a very low UO22+ ion concentration of about 98 % using a low adsorbent mass of 5 mg, and UTSA-76 with this adsorption performance will be among the highly preferred effective adsorbents for uranium adsorption.

In the present paper, an electrochemical method was developed for the determination of pterostilbene (a phenolic phytoalexin) using adsorptive anodic stripping voltammetry at a cathodically pretreated boron doped diamond electrode. The oxidation of compound was irreversible and exhibited an adsorption controlled process which is of pH dependence. The sensitivity of the stripping voltammetric measurements was significantly improved in the presence of cationic surfactant, cetyltrimethylammonium bromide (CTAB). Using square-wave stripping mode, a highly linear analytical curve was obtained for pterostilbene determination in 0.1 M HNO3 solution containing 2 x 10(-4)M CTAB at +0.78V (vs. Ag/AgCl) (after 30 s accumulation at open-circuit condition). The process could be used in the range of 0.005-1.0 mu g mL(-1) (2.0 x 10(-8)-3.9 x 10(-6)M), with a detection limit of 0.0011 mu gmL(-1) (4.3 x 10(-9) M). The proposed method was successfully applied to measure the concentration of pterostilbene in the commercial dietary supplements, with results similar to those obtained using a HPLC method at 95% confidence level. As far as it could be verified, the proposed method is the first one based on the electrochemical investigation of pterostilbene. (C) 2016 Elsevier B.V. All rights reserved.

The natural gross radioactivity in milk from farms in different locations in Van and in milk purchased from Kahramanmara markets were determined. In the milk samples, natural gross alpha and beta activity concentrations were measured. The evaporation and ashing procedures were applied to the milk samples collected from farms and markets. Nuclear spectroscopic systems containing gas-flow proportional counters were used to measure the gross alpha and beta activity concentrations of the milk samples. The gross radioactivity in milk from markets was generally lower than the gross radioactivity in milk from farms. The annual effective dose resulting from gross radioactivity for adults, children, and infants and excess lifetime cancer risk values were calculated. The highest total annual effective dose (AED) values were 1,105.9mSvy-1 for adults, 6,456.2mSvy-1 for children, and 10,267.0mSvy-1 for infants in milk samples. The excess lifetime cancer risk (ELCR) values from gross alpha and beta activities range from 0.010 to 3.870 in milk samples.

Contamination of agricultural soil is a worldwide problem, with heavy metals being a major part of the concern. Bioenergy crop production is also a profitable phytoremediation strategy using biofuel crops for both utilization and remediation of contaminated soil. To investigate lead (Pb) accumulation and tolerance of three different energy crop cultivars, three-week-old healthy seedlings were grown in Hoagland solution supplemented with five different concentrations of Pb 0, 25, 50, 100, and 150 mg/kg. At the end of 30 days, Pb content and translocation, tolerance index, bioconcentration factor, and growth parameters of the plants were evaluated in the study. Results showed that increasing Pb concentrations did not affected the growth and development of Sunburst (Panicum virgatum L.) and Dincer (Carthamus tinctorius L.) cultivars. The highest Pb contents were also found in roots and shoots of Sunburst and Tarsan-1018 (Helianthus annuus L.) cultivars. Dincer cultivar has a high ability to transfer Pb from root to shoot when compared to others. These results suggest that these cultivars may be good candidates for remediation of Pb-contaminated areas for use in biofuel production.

Many kinds of cosmetic products were analyzed to determine gross radioactivity. In this study, gross alpha/beta radioactivity concentrations in 51 cosmetic samples were determined. The examined cosmetic products consist of blusher, eye shadow, lipstick, nail polish, shampoo, hand cream, cellulite cream, baby powder, soap, and toothpaste. The gross alpha–beta activity concentrations were measured with a nuclear spectroscopic system which contains gas-flow proportional counters. The highest gross alpha/beta activity concentrations were found in eye shadow samples of 1.621Bq g−1 for alpha and 6.471Bq g−1 for beta. The total effective doses due to gross radioactivity for skin were calculated. Although the effective dose of eye shadow samples had the highest value, the effective doses due to gross radioactivity concentrations in this study were found to be lower than the radiological limits given by the authorities.

In this study, a new cationic monomer 2-(3-indol-yl)ethylmethacrylamide (IEMA) derived from tryptamine was synthesized in a single step and characterized by Fourier transform infrared (FTIR), H-1-NMR, and C-13-NMR. Then, one-step preparation of novel poly[2-hydroxyethylmethacrylate-c-2-(3-indol-yl)ethylmethacrylamide], or p(HEMA-c-IEMA), copolymeric hydrogels has been performed successfully with IEMA and 2-hydroxyethylmethacrylate (HEMA) as monomers using free radical aqueous polymerization. The hydrogels were characterized with scanning electron microscopy, FTIR, elemental analysis, thermogravimetric analysis, and texture profile analysis instruments. p(HEMA-c-IEMA) hydrogels were used for swelling, diffusion, drug release, and antibacterial activity studies. The drug-release behavior of the hydrogels was determined as a function of time at 37 degrees C in pH1.2 and 7.2. The swelling and drug-release studies showed that an increased IEMA amount caused a higher increase in swelling and drug-release values. Additionally, zero-order, first-order, and Higuchi equation kinetic models were applied to the drug-release data, and the data fit well in the Higuchi model, and the Peppas power-law model was applied to the release mechanism. Finally, the antibacterial activities of the hydrogels were screened against Gram-positive bacteria (Bacillus cereus and Staphylococcus aureus) and Gram-negative bacteria (Escherichia coli and Salmonella typhimurium). (c) 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45550.

The paper presents the results of radiological investigations of food products sampled in the summer and fall of 2011 and 2012 in different parts of Van, Turkey. Gross radioactivity measurements in food products were evaluated. Food items were divided into eight groups: (1) water, (2) fish, (3) cheese products, (4) fruits, (5) vegetables, (6) herbs, (7) walnut and (8) rock salt. The levels of the gross alpha and gross beta radioactivity in all food samples varied widely ranging from 0.070 to 10.885 Bq/g and from 0.132 to 48.285 Bq/g on dry mass basis, respectively. In one sample, gross alpha and gross beta activity concentrations were found to be relatively high according to the other samples and in all samples, the gross alpha radioactivity was measured lower than the gross beta radioactivity. The gross α and gross β activities were measured by using α/β counter of the multi-detector low background system (PIC MPC-9604).

Introduction: S100B protein, which helps nerve development and differentiation, is produced by astrocytes and can be detected in peripheral circulation after brain damage. In this study, we aimed to investigate the relationship between the serum S100B protein level and the infarction volume and clinical outcome and also the early prognostic role of serum S100B protein in patients with ischemic stroke. Method: Fifty patients admitted in the first 24-hour period of acute ischemic stroke were evaluated prospectively, and the findings were compared to those of the controls (n=26). S100B levels of the patients and neurological findings on days 1, 3, and 5 and their functional outcomes on the discharge day and at the first month were recorded by the same examiner. Results: S100B levels were not affected by sex, age, or concomitant systemic diseases. The maximum levels of S100B were recorded on the 3 rd day, and there was a correlation between infarct size and S100B levels. No correlation between the severity of stroke and S100B level was found. There was a poor correlation between the functional outcomes of the patients at the 1 st month and S100B levels and on the 3 rd day. Conclusion: The detection of high S100B levels in peripheral circulation after acute ischemic stroke and the correlations of S100B levels with infarct size (good) and disability (poor) imply that S100B protein may be used as a peripheral marker in acute ischemic stroke patients. (Archives of Neuropsychiatry 2014; 51: 395-400)