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Objective: Amiodarone is an iodine-rich molecule and an effective antiarrhythmic drug. It is a first-line treatment for patients with life-threatening ventricular arrhythmias and for prevention in patients at high risk. The use of amiodarone may cause serious adverse effects such as pharmacotherapy-resistant, life-threatening amiodarone-induced thyrotoxicosis (AIT)leading to rapid deterioration of the patient's condition.According to the European Thyroid Association (ETA) guidelines, emergency thyroidectomy is the first-line treatment option in these cases. ; however, is not always feasible in the clinical setting due to the high anesthetic risk.We aimed to assess the clinical course and results of urgent thyroidectomy and 131-I therapy in patients with severe AIT with worsening of cardiac status., Methods: Retrospective analysis of the clinical course and outcomes of life-threatening AIT refractory to pharmacotherapy in patients hospitalized at a tertiary endocrinology center between 2014 and 2022., Results: An electronic database search identified 75 patients hospitalized for severe AIT. At the time of AIT diagnosis, median Thyroid-stimulating hormone (TSH) concentration was 0.001 mIU/L (range 0.001-0.35), fT4 63.2 pmol/L (range 9.0 - >100), and fT3 10.2 pmol/L (range 3.8-49.3). All patients received optimal conservative treatment. Among them, 20 required urgent radical therapy due to worsening arrhythmias and/or AIT-related heart failure. In this group, 6 patients died before any radical treatment was applied, 6 underwent total thyroidectomy, while 8 patients were successfully treated with 131-I (in 6 cases after rhTSH stimulation). The median dose of 131-I used for the therapy was 784MBq (range 627-860). The decision to treat with 131-I despite low but detectable 131-I uptake (median value 6 %) was made in cases of significant contraindications to anesthesia due to refractory ventricular arrhythmias, exacerbation of severe heart failure unresponsive to cardiac treatment, myocardial infarction during AIT course, massive pulmonary embolism., Conclusion: The decision regarding the optimal time and type of radical treatment of AIT refractory to pharmacotherapy is critical for patients management and should not be delayed. Urgent therapy with 131-I may be an effective therapeutic option in patients who are unsuitable for thyroidectomy due to the high risk of anesthesia., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 Jagiellonian Univerity Medical College.)

Unlabelled: Studies find increasing trend among children, adolescents and young adults to spend excessive amounts of time surfing in the Internet. Another serious problem is the increasing proportion of young people who are overweight and obese. There are only few papers trying to correlate these two trends., Aim: The aims of the study were as follows: identification the extent of Internet addiction among students of Krakow's secondary schools and its correlation with BMI and other health problems., Materials and Methods: Cross-sectional study among 200 pupils of randomly selected Krakow's high schools was conducted. Internet addiction was evaluated by using the Internet Addiction Test (IAT) by Kimberly Young. Each participant filled in an authors' questionnaire about his/her basic social and medical information. For each participant BMI was calculated., Results: It was found that 7% of study group was addicted to the Internet (above 49 points in the IAT questionnaire). Internet addicts had higher BMI. The study revealed also several statistically significant relationships between the level of Internet addiction and the time spent online, BMI, back pain, headache., Conclusions: There is a modest percentage of people addicted to the Internet in the population of high school graduates, but these people often complain of back pain and headaches. BMI is higher among addicted youths. The time spent by high school graduates on online activity is far beyond the time devoted to physical activity., (© 2015 MEDPRESS.)