41 results on '"Afinjuomo, Franklin"'
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2. Physicochemical properties of otic products for Canine Otitis Externa: comparative analysis of marketed products
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Song, Yunmei, Abdella, Sadikalmahdi, Afinjuomo, Franklin, Weir, Emily Josephine, Tan, Jin Quan Eugene, Hill, Peter, Page, Stephen W., and Garg, Sanjay
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- 2023
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3. Printing a cure: A tailored solution for localized drug delivery in liver cancer treatment
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Youssef, Souha H., Ganesan, Raja, Amirmostofian, Marzieh, Kim, Sangseo, Polara, Ruhi, Afinjuomo, Franklin, Song, Yunmei, Chereda, Bradley, Singhal, Nimit, Robinson, Nirmal, and Garg, Sanjay
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- 2024
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4. 3D printed bilayer mucoadhesive buccal film of estradiol: Impact of design on film properties, release kinetics and predicted in vivo performance
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Abdella, Sadikalmahdi, Afinjuomo, Franklin, Song, Yunmie, Upton, Richard, and Garg, Sanjay
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- 2022
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5. Development of a novel chromatographic method for concurrent determination of 5-fluorouracil and cisplatin: Validation, greenness evaluation, and application on drug-eluting film
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Youssef, Souha H., Afinjuomo, Franklin, Song, Yunmei, and Garg, Sanjay
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- 2021
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6. Combining the potential of 3D printed buccal films and nanostructured lipid carriers for personalised cannabidiol delivery
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Abdella, Sadikalmahdi, primary, Kim, Sangseo, additional, Afinjuomo, Franklin, additional, Song, Yunmei, additional, Upton, Richard, additional, and Garg, Sanjay, additional
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- 2023
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7. Synthesis and characterization of a novel inulin hydrogel crosslinked with pyromellitic dianhydride
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Afinjuomo, Franklin, Barclay, Thomas G., Song, Yunmei, Parikh, Ankit, Petrovsky, Nikolai, and Garg, Sanjay
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- 2019
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8. Harnessing the Synergistic Potential of 3D Printed Buccal Films and Nanostructured Lipid Carriers (NLCs) For Personalised Cannabidiol Delivery
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Abdella, Sadikalmahdi, primary, Kim, Sangseo, additional, Afinjuomo, Franklin, additional, Song, Yunmei, additional, Upton, Richard, additional, and Garg, Sanjay, additional
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- 2023
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9. The development of 5-fluorouracil biodegradable implants: A comparative study of PCL/PLGA blends
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Youssef, Souha H., primary, Kim, Sangseo, additional, Khetan, Riya, additional, Afinjuomo, Franklin, additional, Song, Yunmei, additional, and Garg, Sanjay, additional
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- 2023
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10. Development and Optimization of Imiquimod-Loaded Nanostructured Lipid Carriers Using a Hybrid Design of Experiments Approach
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Kim, Sangseo, primary, Abdella, Sadikalmahdi, additional, Abid, Fatima, additional, Afinjuomo, Franklin, additional, Youssef, Souha H, additional, Holmes, Amy, additional, Song, Yunmei, additional, Vaidya, Sachin, additional, and Garg, Sanjay, additional
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- 2023
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11. Advanced Strategies of Drug Delivery via Oral, Topical, and Parenteral Administration Routes: Where Do Equine Medications Stand?
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Song, Yunmei, primary, Day, Candace M., additional, Afinjuomo, Franklin, additional, Tan, Jin-Quan E., additional, Page, Stephen W., additional, and Garg, Sanjay, additional
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- 2023
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12. pH and its applications in targeted drug delivery
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Abdella, Sadikalmahdi, primary, Abid, Fatima, additional, Youssef, Souha H., additional, Kim, Sangseo, additional, Afinjuomo, Franklin, additional, Malinga, Constance, additional, Song, Yunmei, additional, and Garg, Sanjay, additional
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- 2023
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13. Mucoadhesive Buccal Film of Estradiol for Hormonal Replacement Therapy: Development and In-Vivo Performance Prediction
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Abdella, Sadikalmahdi, primary, Afinjuomo, Franklin, additional, Song, Yunmei, additional, Upton, Richard, additional, and Garg, Sanjay, additional
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- 2022
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14. Effect of plasticizers on drug-in-adhesive patches containing 5-fluorouracil
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Kim, Sangseo, primary, Fouladian, Paris, additional, Afinjuomo, Franklin, additional, Song, Yunmei, additional, Youssef, Souha H., additional, Vaidya, Sachin, additional, and Garg, Sanjay, additional
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- 2022
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15. 3D Printing of Thermo-Sensitive Drugs
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Abdella, Sadikalmahdi, primary, Youssef, Souha H., additional, Afinjuomo, Franklin, additional, Song, Yunmei, additional, Fouladian, Paris, additional, Upton, Richard, additional, and Garg, Sanjay, additional
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- 2021
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16. Inulin and Its Application in Drug Delivery
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Afinjuomo, Franklin, primary, Abdella, Sadikalmahdi, additional, Youssef, Souha H., additional, Song, Yunmei, additional, and Garg, Sanjay, additional
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- 2021
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17. Influence of Polymer Composition on the Controlled Release of Docetaxel: A Comparison of Non-Degradable Polymer Films for Oesophageal Drug-Eluting Stents
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Fouladian, Paris, primary, Afinjuomo, Franklin, additional, Arafat, Mohammad, additional, Bergamin, Amanda, additional, Song, Yunmei, additional, Blencowe, Anton, additional, and Garg, Sanjay, additional
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- 2020
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18. Influence of Oxidation Degree on the Physicochemical Properties of Oxidized Inulin
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Afinjuomo, Franklin, primary, Fouladian, Paris, additional, Barclay, Thomas G., additional, Song, Yunmei, additional, Petrovsky, Nikolai, additional, and Garg, Sanjay, additional
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- 2020
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19. Three-dimensional printed 5-fluorouracil eluting polyurethane stents for the treatment of oesophageal cancers
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Fouladian, Paris, primary, Kohlhagen, Jarrod, additional, Arafat, Mohammad, additional, Afinjuomo, Franklin, additional, Workman, Nathan, additional, Abuhelwa, Ahmad Y., additional, Song, Yunmei, additional, Garg, Sanjay, additional, and Blencowe, Anton, additional
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- 2020
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20. Doxorubicin-Loaded Delta Inulin Conjugates for Controlled and Targeted Drug Delivery: Development, Characterization, and In Vitro Evaluation
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Wang, Lixin, primary, Song, Yunmei, additional, Parikh, Ankit, additional, Joyce, Paul, additional, Chung, Rosa, additional, Liu, Liang, additional, Afinjuomo, Franklin, additional, Hayball, John D., additional, Petrovsky, Nikolai, additional, Barclay, Thomas G., additional, and Garg, Sanjay, additional
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- 2019
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21. Synthesis and Characterization of pH-Sensitive Inulin Conjugate of Isoniazid for Monocyte-Targeted Delivery
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Afinjuomo, Franklin, primary, Barclay, Thomas G., additional, Parikh, Ankit, additional, Chung, Rosa, additional, Song, Yunmei, additional, Nagalingam, Gayathri, additional, Triccas, Jamie, additional, Wang, Lixin, additional, Liu, Liang, additional, Hayball, John D., additional, Petrovsky, Nikolai, additional, and Garg, Sanjay, additional
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- 2019
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22. Preparation and Characterization of Oxidized Inulin Hydrogel for Controlled Drug Delivery
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Afinjuomo, Franklin, primary, Fouladian, Paris, additional, Parikh, Ankit, additional, Barclay, Thomas G., additional, Song, Yunmei, additional, and Garg, Sanjay, additional
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- 2019
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23. Design and Characterization of Inulin Conjugate for Improved Intracellular and Targeted Delivery of Pyrazinoic Acid to Monocytes
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Afinjuomo, Franklin, primary, Barclay, Thomas G., additional, Parikh, Ankit, additional, Song, Yunmei, additional, Chung, Rosa, additional, Wang, Lixin, additional, Liu, Liang, additional, Hayball, John D., additional, Petrovsky, Nikolai, additional, and Garg, Sanjay, additional
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- 2019
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24. Development and Optimization of Imiquimod-Loaded Nanostructured Lipid Carriers Using a Hybrid Design of Experiments Approach
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Sangseo Kim, Sadikalmahdi Abdella, Fatima Abid, Franklin Afinjuomo, Souha H Youssef, Amy Holmes, Yunmei Song, Sachin Vaidya, Sanjay Garg, Kim, Sangseo, Abdella, Sadikalmahdi, Abid, Fatima, Afinjuomo, Franklin, Youssef, Souha H, Holmes, Amy, Song, Yunmei, Vaidya, Sachin, and Garg, Sanjay
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skin cancer ,Organic Chemistry ,greenness evaluation ,Biophysics ,Pharmaceutical Science ,Bioengineering ,General Medicine ,nanostructured lipid carrier ,imiquimod ,Biomaterials ,design of experiments ,International Journal of Nanomedicine ,topical patches ,Drug Discovery - Abstract
Sangseo Kim,1 Sadikalmahdi Abdella,1 Fatima Abid,1 Franklin Afinjuomo,1 Souha H Youssef,1 Amy Holmes,1 Yunmei Song,1 Sachin Vaidya,2 Sanjay Garg1 1Centre for Pharmaceutical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, SA, 5000, Australia; 2Central Adelaide Local Health Network, The Queen Elizabeth Hospital, Woodville, SA, 5011, AustraliaCorrespondence: Sanjay Garg, Tel +61 8 8302 1575, Email Sanjay.garg@unisa.edu.auBackground: Imiquimod (IMQ) is an immunomodulating drug that is approved for the treatment of superficial basal cell carcinoma, actinic keratosis, external genital warts and perianal warts. However, IMQ cream (Aldara®) has several drawbacks including poor skin permeation, local toxicity, and compromised patient compliance as a topical pharmacological option.Methods: Our research aimed to develop and optimize nanostructured lipid carriers (NLCs) containing IMQ for the first time using a hybrid design of experiments approach. The optimized formulation was then incorporated into a matrix-type topical patch as an alternative dosage form for topical application and evaluated for IMQ deposition across different skin layers in comparison to the performance of the commercial product. Additionally, our work also attempted to highlight the possibility of implementing environment-friendly practices in our IMQ-NLCs formulation development by reviewing our analytical methods and experimental designs and reducing energy and solvent consumption where possible.Results: In this study, stearyl alcohol, oleic acid, Tween® 80 (polysorbate 80), and Gelucire® 50/13 (Stearoyl polyoxyl-32 glycerides) were selected for formulation development. The formulation was optimized using a 2k factorial design and a central composite design. The optimized formulation achieved the average particle size, polydispersity index, and zeta potential of 75.6 nm, 0.235, and â 30.9 mV, respectively. Subsequently, a matrix-type patch containing IMQ-NLCs was developed and achieved a statistically significant improvement in IMQ deposition in the deeper skin layers. The IMQ deposition from the patch into the dermis layer and receptor chamber was 3.3 ± 0.9 μg/cm2 and 12.3 ± 2.2 μg/cm2, while the commercial cream only deposited 1.0 ± 0.8 μg/cm2 and 1.5 ± 0.5 μg/cm2 of IMQ, respectively.Conclusion: In summary, IMQ-NLC-loaded patches represent great potential as a topical treatment option for skin cancer with improved patient compliance.Keywords: imiquimod, nanostructured lipid carrier, design of experiments, topical patches, skin cancer, greenness evaluation
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- 2023
25. Physicochemical properties of otic products for Canine Otitis Externa: comparative analysis of marketed products
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Yunmei Song, Sadikalmahdi Abdella, Franklin Afinjuomo, Emily Josephine Weir, Jin Quan Eugene Tan, Peter Hill, Stephen W. Page, Sanjay Garg, Song, Yunmei, Abdella, Sadikalmahdi, Afinjuomo, Franklin, Weir, Emily Josephine, Tan, Jin Quan Eugene, Hill, Peter, Page, Stephen W, and Garg, Sanjay
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formulation development ,General Veterinary ,physicochemical properties ,General Medicine ,canine otitis externa - Abstract
Background Otitis externa is a commonly diagnosed dermatological disorder in canines. The pathogens primarily involved in canine otitis externa (COE) include Staphylococcus pseudintermedius, Pseudomonas aeruginosa, Proteus mirabilis, and Malassezia pachydermatis. As COE tends to be superficial, medications delivered topically are often effective and practical in managing the condition. As such, there is a wide variety of approved topical products currently available in the market. The efficacy of topical dosage forms can be dependent on various factors such as the pharmacology of active constituents and the physicochemical properties of the formulation, including pH, viscosity, spreadability, and bio-adhesion. Currently, there is a lack of published literature available on the optimal properties of topical COE products. In this study, we compared the physicochemical properties of nine commercially available otic veterinarian products in Australia used clinically to manage COE. Results Based on our comparative analysis, the pH (6.26 ± 0.04) of an aqueous-based product was similar to a healthy dog’s external auditory canal. Products containing polymers exhibited higher viscosity and bio-adhesion. Spreadability was inversely related to viscosity and Osurnia ® a product with high viscosity demonstrated the lowest spreadability. Aqueous-based otic products showed better syringebility whereas oil-based systems required higher force to expel the products. Variability in droplet size was noted. Derm Otic, Baytril Otic, and Aurizon Ear Drops had the lower standard deviation which indicates they would give a more consistent dose. Conclusions Findings from this work provide considerations for industry researchers or formulation scientists working in the area of otic dosage formulations.
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- 2023
26. The development of 5-fluorouracil biodegradable implants: A comparative study of PCL/PLGA blends
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Souha Youssef, FRANKLIN AFINJUOMO, Yunmei Song, Riya Khetan, Sanjay Garg, Sangseo Kim, Youssef, Souha H, Kim, Sangseo, Khetan, Riya, Afinjuomo, Franklin, Song, Yunmei, and Garg, Sanjay
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solvent casting ,PCL ,blends ,PLGA ,Pharmaceutical Science ,biodegradable - Abstract
Chemotherapy is commonly used in cancer treatment, following resection surgery to reduce recurrence. Systemic administration results in severe side effects, therefore, the concept of drug-eluting implants was adopted, especially biodegradable scaffolds to eliminate the need for additional procedures for removal. Polycaprolactone (PCL) and Poly(lactide-co-glycolide) (PLGA) are biodegradable polymers that showed potential in extended-release drug delivery systems. Their blends combine their benefits, particularly mechanical properties, degradation, and drug release profiles. However, blending these polymers without risking phase separation is challenging. This research presents the development of solvent-cast films composed of different ratios of PCL: PLGA. The blending efficiency was assessed by Fourier Transform Infrared analysis and thermal assessments such as differential scanning calorimetry and thermogravimetric analysis. As PCL is a slow-degrading polymer, the addition of PLGA increased its degradation rate. 5-Fluorouracil (5FU) was used as a model drug and loaded to the blended films, the influence of the ratio of PLGA, percentage of plasticizer, and 5FU loading on the drug release profile was investigated. It was evident that formulations with higher PLGA and plasticizer concentrations showed a reduced burst effect whereas higher 5FU loading resulted in an increased rate of release. Refereed/Peer-reviewed
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- 2023
27. Advanced Strategies of Drug Delivery via Oral, Topical, and Parenteral Administration Routes: Where Do Equine Medications Stand?
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Yunmei Song, Candace M. Day, Franklin Afinjuomo, Jin-Quan E. Tan, Stephen W. Page, Sanjay Garg, Song, Yunmei, Day, Candace M, Afinjuomo, Franklin, Tan, Jin Quan E, Page, Stephen W, and Garg, Sanjay
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oral ,injection ,Pharmaceutical Science ,topical ,NDDSs ,equine - Abstract
Refereed/Peer-reviewed While the global market for veterinary products has been expanding rapidly, there is still a lack of specialist knowledge of equine pharmaceutics. In many cases, the basic structure of the gastrointestinal tract (GIT) and integumentary system of the horse shares similarities with those of humans. Generally, the dosage form developed for humans can be repurposed to deliver equine medications; however, due to physiological variation, the therapeutic outcomes can be unpredictable. This is an area that requires more research, as there is a clear deficiency in literature precedence on drug delivery specifically for horses. Through a careful evaluation of equine anatomy and physiology, novel drug delivery systems (NDDSs) can be developed to adequately address many of the medical ailments of the horse. In addition to this, there are key considerations when delivering oral, topical, and parenteral drugs to horses, deriving from age and species variation. More importantly, NDDSs can enhance the duration of action of active drugs in animals, significantly improving owner compliance; and ultimately, enhancing the convenience of product administration. To address the knowledge gap in equine pharmaceutical formulations, this paper begins with a summary of the anatomy and physiology of the equine gastrointestinal, integumentary, and circulatory systems. A detailed discussion of potential dosage-form related issues affecting horses, and how they can be overcome by employing NDDSs is presented.
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- 2023
28. pH and its applications in targeted drug delivery
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Sadikalmahdi Abdella, Fatima Abid, Souha H. Youssef, Sangseo Kim, Franklin Afinjuomo, Constance Malinga, Yunmei Song, Sanjay Garg, Abdella, Sadikalmahdi, Abid, Fatima, Youssef, Souha H, Kim, Sangseo, Afinjuomo, Franklin, Malinga, Constance, Song, Yunmei, and Garg, Sanjay
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Pharmacology ,acidic ,formulations ,Drug Discovery ,pH-sensitive ,alkaline ,targeted drug delivery ,diseases - Abstract
Refereed/Peer-reviewed Physiologic pH is vital for the normal functioning of tissues and varies in different parts of the body. The varying pH of the body has been exploited to design pH-sensitive smart oral, transdermal and vaginal drug delivery systems (DDS). The DDS demonstrated promising results in hard-to-treat diseases such as cancer and Helicobacter pylori infection. In some cases, a change in pH of tissues or body fluids has also been employed as a useful diagnostic biomarker. This paper aims to comprehensively review the development and applications of pH-sensitive DDS as well as recent advances in the field.
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- 2023
29. Mucoadhesive Buccal Film of Estradiol for Hormonal Replacement Therapy: Development and In-Vivo Performance Prediction
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Sadikalmahdi Abdella, Richard Upton, FRANKLIN AFINJUOMO, Yunmei Song, Sanjay Garg, Abdella, Sadikalmahdi, Afinjuomo, Franklin, Song, Yunmei, Upton, Richard, and Garg, Sanjay
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estradiol ,menopause ,patient-centric ,Pharmaceutical Science ,film ,in vivo prediction ,mucoadhesive - Abstract
Refereed/Peer-reviewed The age-related loss of circulating estrogen that occurs during the menopausal transition manifests itself through a variety of symptoms including vasomotor (hot flushes and night sweats), genito-urinary syndrome (vaginal dryness and urinary symptoms), sexual dysfunction, mood, and sleep disturbance that often last longer than a decade. Furthermore, reductions in estrogen level increase the risks of chronic complications such as osteoporosis, cardiovascular disease, and cognitive decline among others, thereby affecting the quality of life of women. Although oral estrogens are the most widely used therapy for menopausal symptoms, they suffer from poor bioavailability, and there are concerns over their safety, creating a significant concern to consumers. Mucoadhesive buccal films are an innovative dosage form that offers several advantages including avoidance of the first-pass metabolism, fast onset of action, and importantly, improved patient acceptance In the current work, we developed mucoadhesive estradiol film for hormonal replacement therapy using film-forming polymers. Two approaches, namely, co-solvency and nano-emulsion were evaluated to increase solubility and hence incorporate estradiol, a poorly water-soluble drug, into a formulation made from the hydrophilic polymer/s. The films were characterised for their mechanical and physicochemical properties. In-vitro release study showed that about 80% of the drug was released within 6 min from films prepared by the nano-emulsion approach, whereas it took about 10.5 min to get similar drug release from films prepared by the co-solvency approach. The ex-vivo permeation result indicates that about 15% of the drug permeated across the porcine buccal mucosa in the first 10 h from films prepared by the nano-emulsion approach, while permeation across porcine buccal mucosa was only observed at around 24 h from films prepared by the co-solvency method The nano-emulsion films were evaluated for in vivo performance using a convolution technique using R software. The predicted Cmax and Tmax were found to be 740.74 ng mL−1 and 7 min, respectively, which were higher than previously reported in vivo concentration from oral tablets. The results demonstrated that mucoadhesive film of estradiol based on the nano-emulsion approach could be a promising platform for the delivery of estradiol through the buccal mucosa for the treatment of menopausal symptoms.
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- 2022
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30. 3D printed bilayer mucoadhesive buccal film of estradiol: impact of design on film properties, release kinetics and predicted in vivo performance
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Sadikalmahdi Abdella, Richard Upton, FRANKLIN AFINJUOMO, Yunmei Song, Sanjay Garg, Abdella, Sadikalmahdi, Afinjuomo, Franklin, Song, Yunmie, Upton, Richard, and Garg, Sanjay
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Drug Liberation ,Estradiol ,infill patterns ,release kinetics ,Printing, Three-Dimensional ,pressure-assisted microsyringe ,Adhesiveness ,Biological Availability ,Pharmaceutical Science ,estradiol bi-layered film ,in vivo prediction - Abstract
Refereed/Peer-reviewed Despite being an effective therapy for menopausal symptoms, the use of oral estrogen is associated with low bioavailability and serious adverse effects of venous thromboembolism. Individualized therapy has been recommended to maximize benefits and curb the adverse effects, but much has not been done in developing formulations that offer flexibility to personalize therapy. In the present study, we employed an innovative 3D printing technology to design and develop bi-layered estradiol film with different infill patterns with an aim of improving bioavailability and facilitating personalized treatment. Hydroxypropyl cellulose (HPC-H) based formulation exhibited suitable rheological properties and was used as a feedstock to fabricate estradiol films with different infill patterns namely honeycomb, rectangular and plain. The back layer was prepared from a hydroxyethyl cellulose-based formulation. The resulting films were subsequently characterized in terms of their physicochemical, mechanical, environmental impact, and release characteristics among others. Films with a plain infill pattern exhibited significantly higher % elongation break and tensile strength. The in vitro drug release study revealed the fastest drug release profile for rectangular infill (96 % within 4 h) and the slowest drug release was observed for the plain infill pattern (∼35 % within 4 h), highlighting the effect of the infill pattern on release kinetics. Films with honeycomb infill patterns were selected for further characterization based on mechanical and in vitro release properties. No interaction between components of the formulation was observed and the absence of crystallinity in the final product was confirmed by Differential Scanning Calorimetry (DSC) and X-Ray Powder Diffraction analyses (XRD). The force of adhesiveness for the film was 0.13 ± 0.03 N. The predicted AUC 0–4 h, Cmax, and Tmax were 144.85 ng·h/mL, 65.97 ng/mL, and 0.83 h for a film (honeycomb infill pattern) loaded with 1 mg of estradiol. The printing process of films with honeycomb and rectangular infill patterns was evaluated as “green” using the index of Greenness Assessment of Printed Pharmaceuticals (iGAPP) tool. Our finding demonstrates the development of bi-layered estradiol film using Pressure assisted microsyringe (PAM) 3D printing and the influence of infill patterns on release kinetics and mechanical properties. The fabricated film not only facilitates the move towards personalized medicine but could also improve the bioavailability of the drugs by bypassing the hepatic first-pass metabolism and decreasing wash-out by the saliva.
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- 2022
31. Three-dimensional printed 5-fluorouracil eluting polyurethane stents for the treatment of oesophageal cancers
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Franklin Afinjuomo, Yunmei Song, Anton Blencowe, Sanjay Garg, Jarrod Kohlhagen, Paris Fouladian, Nathan Workman, Mohammad Arafat, Ahmad Y. Abuhelwa, Fouladian, Paris, Kohlhagen, Jarrod, Arafat, Mohammad, Afinjuomo, Franklin, Workman, Nathan, Abuhelwa, Ahmad Y, Song, Yunmei, Garg, Sanjay, and Blencowe, Anton
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Antimetabolites, Antineoplastic ,Drug doses ,3d printed ,Materials science ,Esophageal Neoplasms ,medicine.medical_treatment ,Polyurethanes ,Biomedical Engineering ,02 engineering and technology ,cancer treatment ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,medicine ,Humans ,General Materials Science ,Polyurethane ,5-fluorouracil (5-FU) ,Oesophageal Mucosa ,Stent ,Drug-Eluting Stents ,Patient specific ,equipment and supplies ,021001 nanoscience & nanotechnology ,medicine.disease ,Stenosis ,chemistry ,Fluorouracil ,030220 oncology & carcinogenesis ,Printing, Three-Dimensional ,Stents ,0210 nano-technology ,medicine.drug ,Biomedical engineering - Abstract
Oesophageal stents have been widely used to prevent occlusion or stenosis in the treatment of oesophageal cancers. However, stent restenosis caused by tumour ingrowth occurs frequently after stent placement. Incorporating anti-cancer drugs into endoluminal stents is a promising strategy to provide a sustained release of drugs to oesophageal malignant tissues while prolonging the retention of the stent and relieving dysphagia. Recognizing the potential of 3D printing to produce personalised stents with patient specific geometries, we herein report the development of a drug-loaded 3D printed stent for the sustained local delivery of 5-fluorouracil (5-FU) to treat oesophageal cancer. The 3D printed drug-eluting stents (DESs) were fabricated via fused deposition modelling using 5-FU-loaded polyurethane filament. Determination of the 5-FU in the filament and stent (>97%) confirmed that minimal degradation of the drug occurred during the thermal extrusion and 3D printing processes. The physicochemical properties of the stents were investigated using photoacoustic Fourier-transform infrared (PA-FTIR) spectrophotometry, X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA) and mechanical testing. In vitro release studies revealed that the drug-loaded stents provided a sustained release of 5-FU over a period of 110 days and allowed the constant diffusion of 5-FU when in contact with oesophageal mucosa. Furthermore, the 3D printed stents exhibited good stability following sterilization with gamma or UV irradiation, and during accelerated storage. This study demonstrates that 3D printing is a powerful tool for manufacturing DESs which could easily be customized to provide personalized, patient specific geometries and drug doses. Refereed/Peer-reviewed
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- 2020
32. 3D Printing of Thermo-Sensitive Drugs
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Sadikalmahdi Abdella, Paris Fouladian, Sanjay Garg, Franklin Afinjuomo, Souha H. Youssef, Yunmei Song, Richard N. Upton, Abdella, Sadikalmahdi, Youssef, Souha H, Afinjuomo, Franklin, Song, Yunmei, Fouladian, Paris, Upton, Richard, and Garg, Sanjay
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Fabrication ,FDM ,Computer science ,business.industry ,education ,Pharmaceutical Science ,Low melting point ,3D printing ,Review ,law.invention ,thermolabile ,RS1-441 ,Light source ,thermosensitive ,Pharmacy and materia medica ,law ,SSE ,Digital Light Processing ,DLP ,SLA ,Process engineering ,business ,Stereolithography - Abstract
Refereed/Peer-reviewed Three-dimensional (3D) printing is among the rapidly evolving technologies with applications in many sectors. The pharmaceutical industry is no exception, and the approval of the first 3D-printed tablet (Spiratam®) marked a revolution in the field. Several studies reported the fabrication of different dosage forms using a range of 3D printing techniques. Thermosensitive drugs compose a considerable segment of available medications in the market requiring strict temperature control during processing to ensure their efficacy and safety. Heating involved in some of the 3D printing technologies raises concerns regarding the feasibility of the techniques for printing thermolabile drugs. Studies reported that semi-solid extrusion (SSE) is the commonly used printing technique to fabricate thermosensitive drugs. Digital light processing (DLP), binder jetting (BJ), and stereolithography (SLA) can also be used for the fabrication of thermosensitive drugs as they do not involve heating elements. Nonetheless, degradation of some drugs by light source used in the techniques was reported. Interestingly, fused deposition modelling (FDM) coupled with filling techniques offered protection against thermal degradation. Concepts such as selection of low melting point polymers, adjustment of printing parameters, and coupling of more than one printing technique were exploited in printing thermosensitive drugs. This systematic review presents challenges, 3DP procedures, and future directions of 3D printing of thermo-sensitive formulations.
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- 2021
33. Inulin and Its Application in Drug Delivery
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Souha H. Youssef, Sadikalmahdi Abdella, Franklin Afinjuomo, Yunmei Song, Sanjay Garg, Afinjuomo, Franklin, Abdella, Sadikalmahdi, Youssef, Souha H, Song, Yunmei, and Garg, Sanjay
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microparticles ,Liposome ,inulin ,Inulin ,Pharmaceutical Science ,Nanotechnology ,Review ,Prodrug ,Controlled release ,Micelle ,Bioavailability ,RS1-441 ,chemistry.chemical_compound ,Pharmacy and materia medica ,chemistry ,Drug Discovery ,Drug delivery ,Self-healing hydrogels ,drug delivery ,Medicine ,Molecular Medicine ,nanoparticles ,hydrogels - Abstract
Refereed/Peer-reviewed Inulin’s unique and flexible structure, stabilization/protective effects, and organ targeting ability make it an excellent drug delivery carrier compared to other biodegradable polysaccharides. The three hydroxyl groups attached to each fructose unit serve as an anchor for chemical modification. This, in turn, helps in increasing bioavailability, improving cellular uptake, and achieving targeted, sustained, and controlled release of drugs and biomolecules. This review focuses on the various types of inulin drug delivery systems such as hydrogel, conjugates, nanoparticles, microparticles, micelles, liposomes, complexes, prodrugs, and solid dispersion. The preparation and applications of the different inulin drug delivery systems are further discussed. This work highlights the fact that modification of inulin allows the use of this polymer as multifunctional scaffolds for different drug delivery systems.
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- 2021
34. Effect of plasticizers on drug-in-adhesive patches containing 5-fluorouracil
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Sanjay Garg, Sachin Vaidya, Souha H. Youssef, Paris Foulandian, Sangseo Kim, Franklin Afinjuomo, Yunmei Song, Kim, Sangseo, Fouladian, Paris, Afinjuomo, Franklin, Song, Yunmei, Youssef, Souha H, Vaidya, Sachin, and Garg, Sanjay
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plasticizers ,skin cancer ,Plasticizer ,Pharmaceutical Science ,Adhesion ,Methacrylate ,Dibutyl sebacate ,Eudragit® E ,pressure-sensitive adhesive ,chemistry.chemical_compound ,Pharmaceutical Preparations ,chemistry ,Triethyl citrate ,Plasticizers ,Adhesives ,topical patches ,Ultimate tensile strength ,5-fluorouracil ,Fluorouracil ,Adhesive ,Composite material ,Triacetin - Abstract
Topical patches containing 5-fluorouracil (5-FU) are a feasible alternative to overcome the shortcomings of commercial cream for the treatment of non-melanoma skin cancer (NMSC). Plasticizers are a critical component of drug-in-adhesive (DIA) patches as they can significantly affect the mechanical, adhesive and drug release characteristics of the patches. Eudragit® E (EuE) is a methacrylate-based cationic copolymer capable of producing flexible and adhesive films for topical application. In this study, the effect of plasticizers on the mechanical, adhesive and 5-FU release characteristics of EuE-based patches was comprehensively evaluated. While the elongation at break (%) and adhesion of the films were significantly increased with increasing triacetin, dibutyl sebacate (DBS) and triethyl citrate (TEC) concentrations, the tensile strength showed an inverse relationship. EuE plasticized with 40% triacetin, 30% DBS or 40% w/w TEC produced elastic and adhesive films most suitable for topical application. In vitro release studies of the 5-FU-loaded patches demonstrated an initial burst release pattern during the first 10 min followed by a slow release over 120 min. In summary, this study provides important information on effect of plasticizers for preparation of EuE-based patches with desired mechanical, adhesive and release characteristics of 5-FU towards their potential application in the treatment of NMSC. Refereed/Peer-reviewed
- Published
- 2022
35. Influence of Oxidation Degree on the Physicochemical Properties of Oxidized Inulin
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Franklin Afinjuomo, Paris Fouladian, Thomas G. Barclay, Sanjay Garg, Nikolai Petrovsky, Yunmei Song, Afinjuomo, Franklin, Fouladian, Paris, Barclay, Thomas G, Song, Yunmei, Petrovsky, Nikolai, and Garg, Sanjay
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chemistry.chemical_classification ,Thermogravimetric analysis ,Polymers and Plastics ,oxidized inulin ,Sodium periodate ,periodate oxidation ,degree of oxidation and physicochemical properties ,Inulin ,General Chemistry ,Aldehyde ,Article ,aldehyde content ,lcsh:QD241-441 ,chemistry.chemical_compound ,chemistry ,lcsh:Organic chemistry ,Hemiacetal ,Thermal stability ,Fourier transform infrared spectroscopy ,Semicarbazone ,Nuclear chemistry - Abstract
usc This paper reports the oxidation of inulin using varying ratios of sodium periodate and the characterization of the inulin polyaldehyde. The physicochemical properties of the inulin polyaldehyde (oxidized inulin) were characterized using different techniques including 1D NMR spectroscopy, 13C Nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), differential scanning calorimetric (DSC), ultraviolet-visible spectroscopy (UV), and scanning electron microscopy (SEM). The aldehyde peak was not very visible in the FTIR, because the aldehyde functional group exists in a masked form (hemiacetal). The thermal stability of the oxidized inulin decreased with the increasing oxidation degree. The smooth spherical shape of raw inulin was destructed due to the oxidation, as confirmed by the SEM result. The 1HNMR results show some new peaks from 4.8 to 5.0 as well as around 5.63 ppm. However, no aldehyde peak was found around 9.7 ppm. This can be attributed to the hemiacetal. The reaction of oxidized inulin with tert-butyl carbazate produced a carbazone conjugate. There was clear evidence of decreased peak intensity for the proton belonging to the hemiacetal group. This clearly shows that not all of the hemiacetal group can be reverted by carbazate. In conclusion, this work provides vital information as regards changes in the physicochemical properties of the oxidized inulin, which has direct implications when considering the further utilization of this biomaterial. Refereed/Peer-reviewed
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- 2020
36. Synthesis and Characterization of pH-Sensitive Inulin Conjugate of Isoniazid for Monocyte-Targeted Delivery
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Liang Liu, Rosa Chung, Nikolai Petrovsky, Franklin Afinjuomo, Yunmei Song, Jamie Triccas, Lixin Wang, Gayathri Nagalingam, John D. Hayball, Sanjay Garg, Ankit Parikh, Thomas G. Barclay, Afinjuomo, Franklin, Barclay, Thomas G, Parikh, Ankit, Chung, Rosa, Song, Yunmei, Nagalingam, Gayathri, Triccas, Jamie, Wang, Lixin, Liu, Liang, Hayball, John D., Petrovsky, Nikolai, and Garg, Sanjay
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isoniazid ,inulin microparticles ,intracellular delivery ,Inulin ,lcsh:RS1-441 ,Pharmaceutical Science ,02 engineering and technology ,Endocytosis ,Article ,lcsh:Pharmacy and materia medica ,03 medical and health sciences ,chemistry.chemical_compound ,Lysosome ,medicine ,030304 developmental biology ,0303 health sciences ,Chemistry ,Isoniazid ,021001 nanoscience & nanotechnology ,Drug vehicle ,medicine.anatomical_structure ,Targeted drug delivery ,Biochemistry ,tuberculosis ,0210 nano-technology ,Intracellular ,medicine.drug ,Conjugate - Abstract
The use of particles for monocyte-mediated delivery could be a more efficient strategy and approach to achieve intracellular targeting and delivery of antitubercular drugs to host macrophages. In this study, the potential of inulin microparticles to serve as a drug vehicle in the treatment of chronic tuberculosis using a monocytes-mediated drug targeting approach was evaluated. Isoniazid (INH) was conjugated to inulin via hydrazone linkage in order to obtain a pH-sensitive inulin-INH conjugate. The conjugate was then characterized using proton nuclear magnetic resonance (1HNMR), Fourier transform infrared spectroscopy (FTIR) as well as in vitro, cellular uptake and intracellular Mycobacterium tuberculosis (Mtb) antibacterial efficacy. The acid-labile hydrazone linkage conferred pH sensitivity to the inulin-INH conjugate with ~95, 77 and 65% of the drug released after 5 h at pH 4.5, 5.2, and 6.0 respectively. Cellular uptake studies confirm that RAW 264.7 monocytic cells efficiently internalized the inulin conjugates into endocytic compartments through endocytosis. The intracellular efficacy studies demonstrate that the inulin conjugates possess a dose-dependent targeting effect against Mtb-infected monocytes. This was through efficient internalization and cleavage of the hydrazone bond by the acidic environment of the lysosome, which subsequently released the isoniazid intracellularly to the Mtb reservoir. These results clearly suggest that inulin conjugates can serve as a pH-sensitive intracellular drug delivery system for TB treatment Refereed/Peer-reviewed
- Published
- 2019
37. Development of a novel chromatographic method for concurrent determination of 5-fluorouracil and cisplatin: Validation, greenness evaluation, and application on drug-eluting film
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Yunmei Song, Sanjay Garg, Franklin Afinjuomo, Souha H. Youssef, Youssef, Souha H., Afinjuomo, Franklin, Song, Yunmei, and Garg, Sanjay
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Drug ,drug-eluting film ,media_common.quotation_subject ,chromatographic method ,cisplatin ,02 engineering and technology ,Stability result ,01 natural sciences ,Analytical Chemistry ,chemistry.chemical_compound ,medicine ,5-fluorouracil ,Sodium dodecyl sulfate ,Hplc method ,Phosphoric acid ,Spectroscopy ,media_common ,Cisplatin ,Detection limit ,Chromatography ,green analytical method ,010401 analytical chemistry ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,chemistry ,Stress conditions ,0210 nano-technology ,medicine.drug - Abstract
The combination of 5-fluorouracil (5-FU) and cisplatin (Cis) has been used for the treatment of many cancers. The combination demonstrates synergy and improved clinical outcomes encouraging developing a formulation with both drugs. An analytical procedure is essential for formulation studies; however, no method has been reported for the concurrent determination and quantification of both 5-FU and Cis to date. A novel, simple, accurate, and precise HPLC method was developed using a C18 column (250 mm × 4.6 mm, 5 µm) and mobile phase composed of 0.5 mM sodium dodecyl sulfate: methanol (98:2, v/v), adjusted to pH 2.5 with phosphoric acid. A flow rate of 0.5 mL/min was applied and a photodiode array was utilized for detection and the retention times were 9.89 min (265 nm) for 5-FU and 5.36 min (210 nm) for Cis. Validation procedures were performed, and the method was found to be linear at ranges of 0.9–60.0 µg/mL for 5-FU and 6.0–60.0 µg/mL for Cis. The limits of detection (LOD) and quantitation (LOQ) were 0.10 and 0.25 µg/mL for 5-FU and 2.00 and 4.00 µg/mL for Cis, respectively. Other parameters such as precision, selectivity, robustness, and stability results were within acceptable limits. The method was applied to a model co-eluting film and its release profile was studied. Additionally, the method's greenness was evaluated by four assessment tools namely the national environmental method index (NEMI), analytical eco scale assessment (ESA), green analytical procedure index (GAPI), and Analytical GREEnness Metric Approach and Software (AGREE). The results demonstrated compliance with green analytical chemistry (GAC) practices. This research acts as a step towards further investigation of drug stability under different stress conditions and quantification of the intact drugs in presence of their degradation products. Refereed/Peer-reviewed
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- 2021
38. Preparation and Characterization of Oxidized Inulin Hydrogel for Controlled Drug Delivery
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Paris Fouladian, Sanjay Garg, Franklin Afinjuomo, Ankit Parikh, Yunmei Song, Thomas G. Barclay, Afinjuomo, Franklin, Fouladian, Paris, Parikh, Ankit, Barclay, Thomas G, Song, Yunmei, and Garg, Sanjay
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Thermogravimetric analysis ,Biocompatibility ,periodate oxidation ,Inulin ,lcsh:RS1-441 ,Pharmaceutical Science ,02 engineering and technology ,macromolecular substances ,010402 general chemistry ,01 natural sciences ,Article ,lcsh:Pharmacy and materia medica ,chemistry.chemical_compound ,Differential scanning calorimetry ,Fourier transform infrared spectroscopy ,hydrogels ,colon targeting ,oxidized inulin ,technology, industry, and agriculture ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,chemistry ,Drug delivery ,Self-healing hydrogels ,Adipic acid dihydrazide ,0210 nano-technology ,Nuclear chemistry - Abstract
Inulin-based hydrogels are useful carriers for the delivery of drugs in the colon-targeted system and in other biomedical applications. In this project, inulin hydrogels were fabricated by crosslinking oxidized inulin with adipic acid dihydrazide (AAD) without the use of a catalyst or initiator. The physicochemical properties of the obtained hydrogels were further characterized using different techniques, such as swelling experiments, in vitro drug release, degradation, and biocompatibility tests. The cross linking was confirmed with Fourier transform infrared spectroscopy (FTIR), thermal gravimetric analysis (TGA), and differential scanning calorimetry (DSC). In vitro releases of 5-fluorouracil (5FU) from the various inulin hydrogels was enhanced in acidic conditions (pH 5) compared with physiological pH (pH 7.4). In addition, blank gels did not show any appreciable cytotoxicity, whereas 5FU-loaded hydrogels demonstrated efficacy against HCT116 colon cancer cells, which further confirms the potential use of these delivery platforms for direct targeting of 5-FU to the colon Refereed/Peer-reviewed
- Published
- 2019
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39. Design and Characterization of Inulin Conjugate for Improved Intracellular and Targeted Delivery of Pyrazinoic Acid to Monocytes
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Lixin Wang, Liang Liu, Rosa Chung, Nikolai Petrovsky, John D. Hayball, Sanjay Garg, Yunmei Song, Ankit Parikh, Thomas G. Barclay, Franklin Afinjuomo, Afinjuomo, Franklin, Barclay, Thomas G, Parikh, Ankit, Song, Yunmei, Chung, Rosa, Wang, Lixin, Liu, Liang, Hayball, John D, Petrovsky, Nikolai, and Garg, Sanjay
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intracellular delivery ,Inulin ,lcsh:RS1-441 ,Pharmaceutical Science ,02 engineering and technology ,Article ,lcsh:Pharmacy and materia medica ,03 medical and health sciences ,chemistry.chemical_compound ,Pyrazinoic acid ,pyrazinoic acid ,medicine ,Zeta potential ,030304 developmental biology ,0303 health sciences ,inulin ,Monocyte ,021001 nanoscience & nanotechnology ,medicine.anatomical_structure ,chemistry ,tuberculosis ,Drug delivery ,Biophysics ,0210 nano-technology ,Linker ,Intracellular ,Conjugate - Abstract
The propensity of monocytes to migrate into sites of mycobacterium tuberculosis (TB) infection and then become infected themselves makes them potential targets for delivery of drugs intracellularly to the tubercle bacilli reservoir. Conventional TB drugs are less effective because of poor intracellular delivery to this bacterial sanctuary. This study highlights the potential of using semicrystalline delta inulin particles that are readily internalised by monocytes for a monocyte-based drug delivery system. Pyrazinoic acid was successfully attached covalently to the delta inulin particles via a labile linker. The formation of new conjugate and amide bond was confirmed using zeta potential, Proton Nuclear Magnetic Resonance (1HNMR) and Fourier transform infrared spectroscopy (FTIR). Scanning electron microscopy (SEM) confirmed that no significant change in size after conjugation which is an important parameter for monocyte targeting. Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were used to establish the change in thermal properties. The analysis of in-vitro release demonstrated pH-triggered drug cleavage off the delta inulin particles that followed a first-order kinetic process. The efficient targeting ability of the conjugate for RAW 264.7 monocytic cells was supported by cellular uptake studies. Overall, our finding confirmed that semicrystalline delta inulin particles (MPI) can be modified covalently with drugs and such conjugates allow intracellular drug delivery and uptake into monocytes, making this system potentially useful for the treatment of TB. Refereed/Peer-reviewed
- Published
- 2019
40. Doxorubicin-loaded delta inulin conjugates for controlled and targeted drug delivery: development, characterization, and in vitro evaluation
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Nikolai Petrovsky, Ankit Parikh, Sanjay Garg, Yunmei Song, Thomas G. Barclay, John D. Hayball, Lixin Wang, Liang Liu, Rosa Chung, Paul Joyce, Franklin Afinjuomo, Wang, Lixin, Song, Yunmei, Parikh, Ankit, Joyce, Paul, Chung, Rosa, Liu, Liang, Afinjuomo, Franklin, Hayball, John D, Petrovsky, Nikolai, Barclay, Thomas G, and Garg, Sanjay
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Anthracycline ,Pharmaceutical Science ,lcsh:RS1-441 ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,doxorubicin ,Article ,lcsh:Pharmacy and materia medica ,intracellular drug release ,In vivo ,medicine ,Doxorubicin ,anticancer therapy ,pH sensitive ,inulin ,Chemistry ,Monocyte ,targeted delivery ,021001 nanoscience & nanotechnology ,Controlled release ,In vitro ,3. Good health ,0104 chemical sciences ,medicine.anatomical_structure ,Targeted drug delivery ,advax ,Biophysics ,0210 nano-technology ,medicine.drug ,Conjugate - Abstract
Delta inulin, also known as microparticulate inulin (MPI), was modified by covalently attaching doxorubicin to its nanostructured surface for use as a targeted drug delivery vehicle. MPI is readily endocytosed by monocytes, macrophages, and dendritic cells and in this study, we sought to utilize this property to develop a system to target anti-cancer drugs to lymphoid organs. We investigated, therefore, whether MPI could be used as a vehicle to deliver doxorubicin selectively, thereby reducing the toxicity of this antibiotic anthracycline drug. Doxorubicin was covalently attached to the surface of MPI using an acid&ndash, labile linkage to enable pH-controlled release. The MPI-doxorubicin conjugate was characterized using FTIR and SEM, confirming covalent attachment and indicating doxorubicin coupling had no obvious impact on the physical nanostructure, integrity, and cellular uptake of the MPI particles. To simulate the stability of the MPI-doxorubicin in vivo, it was stored in artificial lysosomal fluid (ALF, pH 4.5). Although the MPI-doxorubicin particles were still visible after 165 days in ALF, 53% of glycosidic bonds in the inulin particles were hydrolyzed within 12 days in ALF, reflected by the release of free glucose into solution. By contrast, the fructosidic bonds were much more stable. Drug release studies of the MPI-doxorubicin in vitro, demonstrated a successful pH-dependent controlled release effect. Confocal laser scanning microscopy studies and flow cytometric analysis confirmed that when incubated with live cells, MPI-doxorubicin was efficiently internalized by immune cells. An assay of cell metabolic activity demonstrated that the MPI carrier alone had no toxic effects on RAW 264.7 murine monocyte/macrophage-like cells, but exhibited anti-cancer effects against HCT116 human colon cancer cells. MPI-doxorubicin had a greater anti-cancer cell effect than free doxorubicin, particularly when at lower concentrations, suggesting a drug-sparing effect. This study establishes that MPI can be successfully modified with doxorubicin for chemotherapeutic drug delivery.
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- 2019
41. Synthesis and characterization of a novel inulin hydrogel crosslinked with pyromellitic dianhydride
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Thomas G. Barclay, Nikolai Petrovsky, Franklin Afinjuomo, Yunmei Song, Ankit Parikh, Sanjay Garg, Afinjuomo, Franklin, Barclay, Thomas G, Song, Yunmei, Parikh, Ankitkumar, Petrovsky, Nikolai, and Garg, Sanjay
- Subjects
Pyromellitic dianhydride ,Polymers and Plastics ,General Chemical Engineering ,Carboxylic acid ,One-pot synthesis ,Inulin ,02 engineering and technology ,macromolecular substances ,pyromellitic dianhydride ,010402 general chemistry ,01 natural sciences ,Biochemistry ,chemistry.chemical_compound ,Materials Chemistry ,medicine ,Environmental Chemistry ,crosslinking ,Fourier transform infrared spectroscopy ,Thermal analysis ,chemistry.chemical_classification ,technology, industry, and agriculture ,General Chemistry ,021001 nanoscience & nanotechnology ,hydrogelInulin ,0104 chemical sciences ,chemistry ,Self-healing hydrogels ,Swelling ,medicine.symptom ,pH dependent swelling ,0210 nano-technology ,Nuclear chemistry - Abstract
Smart hydrogels with pH and enzyme triggered release suitable for colon specific drug delivery were prepared by crosslinking inulin with pyromellitic dianhydride (PMDA) in a simple one pot synthesis. Back titration, Fourier transform infrared spectroscopy (FTIR) and ultraviolet spectrophotometry (UV) demonstrated that the hydrogel crosslinking reaction resulted in ester linkages and carboxylic acid groups and that the amount of the crosslinker in the hydrogel increased with increasing PMDA concentration in the crosslinking reaction. Thermal analysis and scanning electron microscopy (SEM) confirmed the chemical change by illustrating the hydrogels changed thermal properties and appearance compared to inulin. This hydrogel showed excellent swelling in water and the degree of swelling was inversely proportional to the cross-linking density, as determined using Flory-Rehner theory. Due to the presence of the carboxylic acid groups in the structure, the swelling was pH dependent, with significantly reduced swelling as acidity decreased from pH 7.4 to pH 1.2. Refereed/Peer-reviewed
- Published
- 2019
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