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185 results on '"Agostini, V"'

1. Measurement of the cosmic ray flux by an ArduSiPM-based muon telescope in the framework of the Lab2Go project

Author

Agostini, V., Arcese, B., Ascani, N., Astone, P., Bocci, V., Caperna, S., Casaburo, F., Cerica, A., D'Auria, C., De Bonis, G., Deda, D., Di Mauro, F., Di Vico, A., Faccini, R., Frasca, L., Galuppi, G., Giovannetti, G., Iacoangeli, F., Ludovici, G., Martone, L., Marucci, B., Mizzoni, L., Moriconi, A., Organtini, G., Piacentini, F., Pietrobono, A., Pongelli, F., Severa, F., and Vona, D.

Subjects
Physics - Physics Education
Abstract

Whitin Istituto Nazionale di Fisica Nucleare (INFN) outreach activities, the Lab2Go project is of great significance. Its goal is involving high school teachers and students in several laboratory activities, aiming at increasing the weight of experimental contents in teaching and learning. In this article we present the measurement, carried out in the framework of the Lab2Go project, of the cosmic muon flux made by an ArduSiPM-based muon telescope.

Published
2023

2. Strategies to prevent blood loss and reduce transfusion in emergency general surgery, WSES-AAST consensus paper

Author

Coccolini, F, Shander, A, Ceresoli, M, Moore, E, Tian, B, Parini, D, Sartelli, M, Sakakushev, B, Doklestich, K, Abu-Zidan, F, Horer, T, Shelat, V, Hardcastle, T, Bignami, E, Kirkpatrick, A, Weber, D, Kryvoruchko, I, Leppaniemi, A, Tan, E, Kessel, B, Isik, A, Cremonini, C, Forfori, F, Ghiadoni, L, Chiarugi, M, Ball, C, Ottolino, P, Hecker, A, Mariani, D, Melai, E, Malbrain, M, Agostini, V, Podda, M, Picetti, E, Kluger, Y, Rizoli, S, Litvin, A, Maier, R, Beka, S, De Simone, B, Bala, M, Perez, A, Ordonez, C, Bodnaruk, Z, Cui, Y, Calatayud, A, de Angelis, N, Amico, F, Pikoulis, E, Damaskos, D, Coimbra, R, Chirica, M, Biffl, W, Catena, F, Coccolini F., Shander A., Ceresoli M., Moore E., Tian B., Parini D., Sartelli M., Sakakushev B., Doklestich K., Abu-Zidan F., Horer T., Shelat V., Hardcastle T., Bignami E., Kirkpatrick A., Weber D., Kryvoruchko I., Leppaniemi A., Tan E., Kessel B., Isik A., Cremonini C., Forfori F., Ghiadoni L., Chiarugi M., Ball C., Ottolino P., Hecker A., Mariani D., Melai E., Malbrain M., Agostini V., Podda M., Picetti E., Kluger Y., Rizoli S., Litvin A., Maier R., Beka S. G., De Simone B., Bala M., Perez A. M., Ordonez C., Bodnaruk Z., Cui Y., Calatayud A. P., de Angelis N., Amico F., Pikoulis E., Damaskos D., Coimbra R., Chirica M., Biffl W. L., Catena F., Coccolini, F, Shander, A, Ceresoli, M, Moore, E, Tian, B, Parini, D, Sartelli, M, Sakakushev, B, Doklestich, K, Abu-Zidan, F, Horer, T, Shelat, V, Hardcastle, T, Bignami, E, Kirkpatrick, A, Weber, D, Kryvoruchko, I, Leppaniemi, A, Tan, E, Kessel, B, Isik, A, Cremonini, C, Forfori, F, Ghiadoni, L, Chiarugi, M, Ball, C, Ottolino, P, Hecker, A, Mariani, D, Melai, E, Malbrain, M, Agostini, V, Podda, M, Picetti, E, Kluger, Y, Rizoli, S, Litvin, A, Maier, R, Beka, S, De Simone, B, Bala, M, Perez, A, Ordonez, C, Bodnaruk, Z, Cui, Y, Calatayud, A, de Angelis, N, Amico, F, Pikoulis, E, Damaskos, D, Coimbra, R, Chirica, M, Biffl, W, Catena, F, Coccolini F., Shander A., Ceresoli M., Moore E., Tian B., Parini D., Sartelli M., Sakakushev B., Doklestich K., Abu-Zidan F., Horer T., Shelat V., Hardcastle T., Bignami E., Kirkpatrick A., Weber D., Kryvoruchko I., Leppaniemi A., Tan E., Kessel B., Isik A., Cremonini C., Forfori F., Ghiadoni L., Chiarugi M., Ball C., Ottolino P., Hecker A., Mariani D., Melai E., Malbrain M., Agostini V., Podda M., Picetti E., Kluger Y., Rizoli S., Litvin A., Maier R., Beka S. G., De Simone B., Bala M., Perez A. M., Ordonez C., Bodnaruk Z., Cui Y., Calatayud A. P., de Angelis N., Amico F., Pikoulis E., Damaskos D., Coimbra R., Chirica M., Biffl W. L., and Catena F.

Abstract

Emergency general surgeons often provide care to severely ill patients requiring surgical interventions and intensive support. One of the primary drivers of morbidity and mortality is perioperative bleeding. In general, when addressing life threatening haemorrhage, blood transfusion can become an essential part of overall resuscitation. However, under all circumstances, indications for blood transfusion must be accurately evaluated. When patients decline blood transfusions, regardless of the reason, surgeons should aim to provide optimal care and respect and accommodate each patient’s values and target the best outcome possible given the patient’s desires and his/her clinical condition. The aim of this position paper was to perform a review of the existing literature and to provide comprehensive recommendations on organizational, surgical, anaesthetic, and haemostatic strategies that can be used to provide optimal peri-operative blood management, reduce, or avoid blood transfusions and ultimately improve patient outcomes.

Published
2024

5. Automatic sleep scoring via deep learning: do it at home!

Author

Fiorillo, L., primary, Monachino, G., additional, Bechny, M., additional, Palo, G., additional, Samaras-Tsakiris, K., additional, du Toit, W., additional, Meier, E., additional, Melnykowycz, M., additional, Agostini, V., additional, and Faraci, F.D., additional

Published
2024
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9. Immunochip analysis identifies novel susceptibility loci in the human leukocyte antigen region for acquired thrombotic thrombocytopenic purpura

Author

Mancini, I., Ricaño‐Ponce, I., Pappalardo, E., Cairo, A., Gorski, M.M., Casoli, G., Ferrari, B., Alberti, M., Mikovic, D., Noris, M., Wijmenga, C., Peyvandi, F., Rinaldi, E., Melpignano, A., Campus, S., Podda, R.A., Caria, C., Caddori, A., Di Francesco, E., Giuffrida, G., Agostini, V., Roncarati, U., Mannarella, C., Fragasso, A., Podda, G.M., Bertinato, E., Cerbone, A.M., Tufano, A., Loffredo, G., Poggi, V., Pizzuti, M., Re, G., Ronchi, M., Codeluppi, K., Facchini, L., De Fanti, A., Amarri, S., Trisolini, S.M., Capria, S., Aprile, L., Defina, M., and Cerù, S.

Published
2016
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10. Comment : A community-sourced glossary of open scholarship terms

Author

Parsons, S, Azevedo, F, Elsherif, MM, Guay, S, Shahim, ON, Govaart, GH, Norris, E, O’Mahony, A, Parker, AJ, Todorovic, A, Pennington, CR, Garcia-Pelegrin, E, Lazić, A, Robertson, O, Middleton, SL, Valentini, B, McCuaig, J, Baker, BJ, Collins, E, Fillon, AA, Lonsdorf, TB, Lim, MC, Vanek, N, Kovacs, M, Roettger, TB, Rishi, S, Miranda, JF, Jaquiery, M, Stewart, SLK, Agostini, V, Stewart, AJ, Izydorczak, K, Ashcroft-Jones, S, Hartmann, H, Ingham, M, Yamada, Y, Vasilev, MR, Dechterenko, F, Albayrak-Aydemir, N, Yang, YF, LaPlume, AA, Wolska, JK, Henderson, EL, Zaneva, M, Farrar, BG, Mounce, R, Kalandadze, T, Li, W, Xiao, Q, Ross, RM, Yeung, SK, Liu, M, Vandegrift, ML, Kekecs, Z, Topor, MK, Baum, MA, Williams, EA, Assaneea, AA, Bret, A, Cashin, AG, Ballou, N, Dumbalska, T, Kern, BMJ, Melia, CR, Arendt, B, Vineyard, GH, Pickering, JS, Evans, TR, Laverty, C, Woodward, EA, Moreau, D, Roche, DG, Rinke, EM, Reid, G, Garcia-Garzon, E, Verheyen, S, Kocalar, HE, Blake, AR, Cockcroft, JP, Micheli, L, Bret, BB, Flack, ZM, Szaszi, B, Weinmann, M, Lecuona, O, Schmidt, B, Ngiam, WX, Mendes, AB, Francis, S, Gall, BJ, Paul, M, Keating, CT, Grose-Hodge, M, Bartlett, JE, Iley, BJ, Spitzer, L, Pownall, M, Graham, CJ, Wingen, T, Terry, J, Parsons, S, Azevedo, F, Elsherif, MM, Guay, S, Shahim, ON, Govaart, GH, Norris, E, O’Mahony, A, Parker, AJ, Todorovic, A, Pennington, CR, Garcia-Pelegrin, E, Lazić, A, Robertson, O, Middleton, SL, Valentini, B, McCuaig, J, Baker, BJ, Collins, E, Fillon, AA, Lonsdorf, TB, Lim, MC, Vanek, N, Kovacs, M, Roettger, TB, Rishi, S, Miranda, JF, Jaquiery, M, Stewart, SLK, Agostini, V, Stewart, AJ, Izydorczak, K, Ashcroft-Jones, S, Hartmann, H, Ingham, M, Yamada, Y, Vasilev, MR, Dechterenko, F, Albayrak-Aydemir, N, Yang, YF, LaPlume, AA, Wolska, JK, Henderson, EL, Zaneva, M, Farrar, BG, Mounce, R, Kalandadze, T, Li, W, Xiao, Q, Ross, RM, Yeung, SK, Liu, M, Vandegrift, ML, Kekecs, Z, Topor, MK, Baum, MA, Williams, EA, Assaneea, AA, Bret, A, Cashin, AG, Ballou, N, Dumbalska, T, Kern, BMJ, Melia, CR, Arendt, B, Vineyard, GH, Pickering, JS, Evans, TR, Laverty, C, Woodward, EA, Moreau, D, Roche, DG, Rinke, EM, Reid, G, Garcia-Garzon, E, Verheyen, S, Kocalar, HE, Blake, AR, Cockcroft, JP, Micheli, L, Bret, BB, Flack, ZM, Szaszi, B, Weinmann, M, Lecuona, O, Schmidt, B, Ngiam, WX, Mendes, AB, Francis, S, Gall, BJ, Paul, M, Keating, CT, Grose-Hodge, M, Bartlett, JE, Iley, BJ, Spitzer, L, Pownall, M, Graham, CJ, Wingen, T, and Terry, J

Abstract

Open scholarship has transformed research, and introduced a host of new terms in the lexicon of researchers. The ‘Framework for Open and Reproducible Research Teaching’ (FORRT) community presents a crowdsourced glossary of open scholarship terms to facilitate education and effective communication between experts and newcomers.

Published
2022

11. A community-sourced glossary of open scholarship terms

Author

Parsons, S., Azevedo, F., Elsherif, M.M., Guay, S., Shahim, O.N., Govaart, G.H., Norris, E., O'Mahony, A., Parker, A.J., Todorovic, A., Pennington, C.R., Garcia-Pelegrin, E., Lazić, A., Robertson, O., Middleton, S.L., Valentini, B., McCuaig, J., Baker, B.J., Collins, E., Fillon, A.A., Lonsdorf, T.B., Lim, M.C., Vanek, N., Kovacs, M., Roettger, T.B., Rishi, S., Miranda, J.F., Jaquiery, M., Stewart, S.L.K., Agostini, V., Stewart, A.J., Izydorczak, K., Ashcroft-Jones, S., Hartmann, H., Ingham, M., Yamada, Y., Vasilev, M.R., Dechterenko, F., Albayrak-Aydemir, N., Yang, Y.F., LaPlume, A.A., Wolska, J.K., Henderson, E.L., Zaneva, M., Farrar, B.G., Mounce, R., Kalandadze, T., Li, W., Xiao, Q., Ross, R.M., Yeung, S.K., Liu, M., Vandegrift, M.L., Kekecs, Z., Topor, M.K., Baum, M.A., Williams, E.A., Assaneea, A.A., Bret, A., Cashin, A.G., Ballou, N., Dumbalska, T., Kern, B.M.J., Melia, C.R., Arendt, B., Vineyard, G.H., Pickering, J.S., Evans, T.R., Laverty, C., Woodward, E.A., Moreau, D., Roche, D.G., Rinke, E.M., Reid, G., Garcia-Garzon, E., Verheyen, S., Kocalar, H.E., Blake, A.R., Cockcroft, J.P., Micheli, L., Bret, B.B., Flack, Z.M., Szaszi, B., Weinmann, M., Lecuona, O., Schmidt, B., Ngiam, W.X., Mendes, A.B., Francis, S., Gall, B.J., Paul, M., Keating, C.T., Grose-Hodge, M., Bartlett, J.E., Iley, B.J., Spitzer, L., Pownall, M., Graham, C.J., Wingen, T., Terry, J., Al-Hoorie, A.H., Aczel, B., Parsons, S., Azevedo, F., Elsherif, M.M., Guay, S., Shahim, O.N., Govaart, G.H., Norris, E., O'Mahony, A., Parker, A.J., Todorovic, A., Pennington, C.R., Garcia-Pelegrin, E., Lazić, A., Robertson, O., Middleton, S.L., Valentini, B., McCuaig, J., Baker, B.J., Collins, E., Fillon, A.A., Lonsdorf, T.B., Lim, M.C., Vanek, N., Kovacs, M., Roettger, T.B., Rishi, S., Miranda, J.F., Jaquiery, M., Stewart, S.L.K., Agostini, V., Stewart, A.J., Izydorczak, K., Ashcroft-Jones, S., Hartmann, H., Ingham, M., Yamada, Y., Vasilev, M.R., Dechterenko, F., Albayrak-Aydemir, N., Yang, Y.F., LaPlume, A.A., Wolska, J.K., Henderson, E.L., Zaneva, M., Farrar, B.G., Mounce, R., Kalandadze, T., Li, W., Xiao, Q., Ross, R.M., Yeung, S.K., Liu, M., Vandegrift, M.L., Kekecs, Z., Topor, M.K., Baum, M.A., Williams, E.A., Assaneea, A.A., Bret, A., Cashin, A.G., Ballou, N., Dumbalska, T., Kern, B.M.J., Melia, C.R., Arendt, B., Vineyard, G.H., Pickering, J.S., Evans, T.R., Laverty, C., Woodward, E.A., Moreau, D., Roche, D.G., Rinke, E.M., Reid, G., Garcia-Garzon, E., Verheyen, S., Kocalar, H.E., Blake, A.R., Cockcroft, J.P., Micheli, L., Bret, B.B., Flack, Z.M., Szaszi, B., Weinmann, M., Lecuona, O., Schmidt, B., Ngiam, W.X., Mendes, A.B., Francis, S., Gall, B.J., Paul, M., Keating, C.T., Grose-Hodge, M., Bartlett, J.E., Iley, B.J., Spitzer, L., Pownall, M., Graham, C.J., Wingen, T., Terry, J., Al-Hoorie, A.H., and Aczel, B.

Abstract

Item does not contain fulltext

Published
2022

12. A Ge.F.I. – ISFG European collaborative study on DNA identification of Cannabis sativa samples using a 13-locus multiplex STR method

Author

Di Nunzio, M., primary, Agostini, V., additional, Alessandrini, F., additional, Barrot-Feixat, C., additional, Berti, A., additional, Bini, C., additional, Bottinelli, M., additional, Carnevali, E., additional, Corradini, B., additional, Fabbri, M., additional, Fattorini, P., additional, Garofano, P., additional, Gino, S., additional, Mameli, A., additional, Marino, A., additional, Previderè, C., additional, Robino, C., additional, Romano, C., additional, Tozzo, P., additional, Verzeletti, A., additional, Buscemi, L., additional, Gangitano, D., additional, and Di Nunzio, C., additional

Published
2021
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15. Fulminant Versus Acute Nonfulminant Myocarditis in Patients With Left Ventricular Systolic Dysfunction

Author

Ammirati, E, Veronese, G, Brambatti, M, Merlo, M, Cipriani, M, Potena, L, Sormani, P, Aoki, T, Sugimura, K, Sawamura, A, Okumura, T, Pinney, S, Hong, K, Shah, P, Braun, O, Van de Heyning, C, Montero, S, Petrella, D, Huang, F, Schmidt, M, Raineri, C, Lala, A, Varrenti, M, Foa, A, Leone, O, Gentile, P, Artico, J, Agostini, V, Patel, R, Garascia, A, Van Craenenbroeck, E, Hirose, K, Isotani, A, Murohara, T, Arita, Y, Sionis, A, Fabris, E, Hashem, S, Garcia-Hernando, V, Oliva, F, Greenberg, B, Shimokawa, H, Sinagra, G, Adler, E, Frigerio, M, Camici, P, Ammirati E., Veronese G., Brambatti M., Merlo M., Cipriani M., Potena L., Sormani P., Aoki T., Sugimura K., Sawamura A., Okumura T., Pinney S., Hong K., Shah P., Braun O., Van de Heyning C. M., Montero S., Petrella D., Huang F., Schmidt M., Raineri C., Lala A., Varrenti M., Foa A., Leone O., Gentile P., Artico J., Agostini V., Patel R., Garascia A., Van Craenenbroeck E. M., Hirose K., Isotani A., Murohara T., Arita Y., Sionis A., Fabris E., Hashem S., Garcia-Hernando V., Oliva F., Greenberg B., Shimokawa H., Sinagra G., Adler E. D., Frigerio M., Camici P. G., Ammirati, E, Veronese, G, Brambatti, M, Merlo, M, Cipriani, M, Potena, L, Sormani, P, Aoki, T, Sugimura, K, Sawamura, A, Okumura, T, Pinney, S, Hong, K, Shah, P, Braun, O, Van de Heyning, C, Montero, S, Petrella, D, Huang, F, Schmidt, M, Raineri, C, Lala, A, Varrenti, M, Foa, A, Leone, O, Gentile, P, Artico, J, Agostini, V, Patel, R, Garascia, A, Van Craenenbroeck, E, Hirose, K, Isotani, A, Murohara, T, Arita, Y, Sionis, A, Fabris, E, Hashem, S, Garcia-Hernando, V, Oliva, F, Greenberg, B, Shimokawa, H, Sinagra, G, Adler, E, Frigerio, M, Camici, P, Ammirati E., Veronese G., Brambatti M., Merlo M., Cipriani M., Potena L., Sormani P., Aoki T., Sugimura K., Sawamura A., Okumura T., Pinney S., Hong K., Shah P., Braun O., Van de Heyning C. M., Montero S., Petrella D., Huang F., Schmidt M., Raineri C., Lala A., Varrenti M., Foa A., Leone O., Gentile P., Artico J., Agostini V., Patel R., Garascia A., Van Craenenbroeck E. M., Hirose K., Isotani A., Murohara T., Arita Y., Sionis A., Fabris E., Hashem S., Garcia-Hernando V., Oliva F., Greenberg B., Shimokawa H., Sinagra G., Adler E. D., Frigerio M., and Camici P. G.

Abstract

Background: Fulminant myocarditis (FM) is a form of acute myocarditis characterized by severe left ventricular systolic dysfunction requiring inotropes and/or mechanical circulatory support. A single-center study found that a patient with FM had better outcomes than those with acute nonfulminant myocarditis (NFM) presenting with left ventricular systolic dysfunction, but otherwise hemodynamically stable. This was recently challenged, so disagreement still exists. Objectives: This study sought to provide additional evidence on the outcome of FM and to ascertain whether patient stratification based on the main histologic subtypes can provide additional prognostic information. Methods: A total of 220 patients (median age 42 years, 46.3% female) with histologically proven acute myocarditis (onset of symptoms <30 days) all presenting with left ventricular systolic dysfunction were included in a retrospective, international registry comprising 16 tertiary hospitals in the United States, Europe, and Japan. The main endpoint was the occurrence of cardiac death or heart transplantation within 60 days from admission and at long-term follow-up. Results: Patients with FM (n = 165) had significantly higher rates of cardiac death and heart transplantation compared with those with NFM (n = 55), both at 60 days (28.0% vs. 1.8%, p = 0.0001) and at 7-year follow-up (47.7% vs. 10.4%, p < 0.0001). Using Cox multivariate analysis, the histologic subtype emerged as a further variable affecting the outcome in FM patients, with giant cell myocarditis having a significantly worse prognosis compared with eosinophilic and lymphocytic myocarditis. In a subanalysis including only adults with lymphocytic myocarditis, the main endpoints occurred more frequently in FM compared with in NFM both at 60 days (19.5% vs. 0%, p = 0.005) and at 7-year follow up (41.4% vs. 3.1%, p = 0.0004). Conclusions: This international registry confirms that patients with FM have higher rates of cardiac death and heart

Published
2019

16. Additional file 1 of Muscle synergies for the control of single-limb stance with and without visual information in young individuals

Author

Labanca, L., Ghislieri, M., Knaflitz, M., Barone, G., Bragonzoni, L., Agostini, V., and Benedetti, M. G.

Subjects
genetic structures, eye diseases
Abstract

Additional file 1. Example of muscle synergies in one of the participants. Activation coefficients and weight vectors obtained from a representative healthy subject of the sample population considering two different task conditions: eyes open and eyes closed conditions

Published
2021
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18. The features of acquired thrombotic thrombocytopenic purpura occurring at advanced age

Author

Agosti, P, Mancini, I, Artoni, A, Ferrari, B, Pontiggia, S, Trisolini, Sm, Facchini, L, Peyvandi, F, Capria, S, Codeluppi, K, Rinaldi, E, Pastore, D, Campus, S, Podda, Ra, Caria, C, Caddori, A, Nicolosi, D, Giuffrida, G, Agostini, V, Roncarati, U, Mannarella, C, Fragasso, A, Podda, Gm, Birocchi, S, Cerbone, Am, Tufano, A, Loffredo, G, Menna, G, Pizzuti, M, Ronchi, M, De Fanti, A, Amarri, S, Defina, M, Bocchia, M, Ceru, S, Gattillo, S, Agosti, P., Mancini I., Artoni A., Ferrari B., Pontiggia S., Trisolini S. M., Facchini L., Peyvandi F., and Tufano, A.

Subjects
medicine.medical_specialty, Thrombotic microangiopathy, ADAMTS13 Protein, Hemorrhage, Disease, 030204 cardiovascular system & hematology, Kidney, Adamts13 activity, 03 medical and health sciences, 0302 clinical medicine, Elderly, Older patients, Internal medicine, medicine, Humans, Registries, Acute thrombotic thrombocytopenic purpura management, ADAMTS13, Rare disease, Aged, Acquired Thrombotic Thrombocytopenic Purpura, Purpura, Thrombotic Thrombocytopenic, business.industry, Hematology, Microangiopathic hemolytic anemia, medicine.disease, Cross-Sectional Studies, 030220 oncology & carcinogenesis, Female, business
Abstract

Introduction: Acquired thrombotic thrombocytopenic purpura (aTTP) is a rare life-threatening thrombotic microangiopathy (TMA) affecting more frequently women of 30–50 years of age. There is scarce information on the clinical features of aTTP occurring in the elderly. Our goal was to evaluate the impact of an elderly-onset disease on the expression, severity and management of aTTP. Materials and methods: We performed a cross-sectional study of patients enrolled in the Milan TTP Registry (www.ttpdatabase.org) after a first acute episode of aTTP from January 2002 to March 2018. The aTTP diagnosis was suspected on the basis of the presence of thrombocytopenia and microangiopathic hemolytic anemia with no alternative causes, and was confirmed centrally by a severe plasma deficiency of ADAMTS13 activity (

Published
2020

33. Blood Component Therapy and Coagulopathy in Trauma: A Systematic Review of the Literature from the Trauma Update Group

Author

Poole D., Cortegiani A., Chieregato A., Russo E., Pellegrini C., De Blasio E., Mengoli F., Volpi A., Grossi S., Gianesello L., Orzalesi V., Fossi F., Chiara O., Coniglio C., Gordini G., Blasio D., Nardi G., Agostini V., Bini G., Cimbanassi S., Cingolani E., Monesi A., Sanson G., Tacconi C., Poole D., Cortegiani A., Chieregato A., Russo E., Pellegrini C., De Blasio E., Mengoli F., Volpi A., Grossi S., Gianesello L., Orzalesi V., Fossi F., Chiara O., Coniglio C., Gordini G., Blasio D., Nardi G., Agostini V., Bini G., Cimbanassi S., Cingolani E., Monesi A., Sanson G., Tacconi C., Poole, D., Cortegiani, A., Chieregato, A., Russo, E., Pellegrini, C., De Blasio, E., Mengoli, F., Volpi, A., Grossi, S., Gianesello, L., Orzalesi, V., Fossi, F., Chiara, O., Coniglio, C., Gordini, G., Nardi, G., Agostini, V., Cimbanassi, S., Cingolani, E., Monesi, A., Sanson, G., and Tacconi, C.

Subjects
Tranexamic acid, Physiology, Glycobiology, lcsh:Medicine, Cardiovascular Medicine, Pathology and Laboratory Medicine, Biochemistry, Vascular Medicine, law.invention, Database and Informatics Methods, Fresh frozen plasma, 0302 clinical medicine, Randomized controlled trial, Coagulopathy, Animal Cells, law, Antifibrinolytic agent, Fibrinogen, Medicine and Health Sciences, 030212 general & internal medicine, Database Searching, lcsh:Science, Multidisciplinary, Plasma Exchange, Hematology, Blood Coagulation Disorders, Clinical Laboratory Sciences, Antifibrinolytic Agents, Body Fluids, Blood, trauma, Tranexamic Acid, Cardiovascular Diseases, Research Design, Meta-analysis, Observational Studies, Anatomy, Cellular Types, Research Article, Platelets, medicine.medical_specialty, Death Rates, Hemorrhage, Blood Component Transfusion, Research and Analysis Methods, External validity, 03 medical and health sciences, Signs and Symptoms, Population Metrics, Diagnostic Medicine, medicine, Humans, Blood Transfusion, Mortality, Intensive care medicine, Blood Coagulation, Wounds and Injuries, Biochemistry, Genetics and Molecular Biology (all), Agricultural and Biological Sciences (all), Demography, Glycoproteins, Blood Cells, Population Biology, Coagulation Disorders, Transfusion Medicine, business.industry, lcsh:R, Bleeding, Biology and Life Sciences, 030208 emergency & critical care medicine, Cell Biology, medicine.disease, Surgery, People and Places, lcsh:Q, Observational study, Packed red blood cells, business
Abstract

Background Traumatic coagulopathy is thought to increase mortality and its treatment to reduce preventable deaths. However, there is still uncertainty in this field, and available literature results may have been overestimated. Methods We searched the MEDLINE database using the PubMed platform. We formulated four queries investigating the prognostic weight of traumatic coagulopathy defined according to conventional laboratory testing, and the effectiveness in reducing mortality of three different treatments aimed at contrasting coagulopathy (high fresh frozen plasma/packed red blood cells ratios, fibrinogen, and tranexamic acid administration). Randomized controlled trials were selected along with observational studies that used a multivariable approach to adjust for confounding. Strict criteria were adopted for quality assessment based on a two-step approach. First, we rated quality of evidence according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria. Then, this rating was downgraded if other three criteria were not met: high reporting quality according to shared standards, absence of internal methodological and statistical issues not detailed by the GRADE system, and absence of external validity issues. Results With few exceptions, the GRADE rating, reporting and methodological quality of observational studies was “very low”, with frequent external validity issues. The only two randomized trials retrieved were, instead, of high quality. Only weak evidence was found for a relation between coagulopathy and mortality. Very weak evidence was found supporting the use of fibrinogen administration to reduce mortality in trauma. On the other hand, we found high evidence that the use of 1:1 vs. 1:2 high fresh frozen plasma/packed red blood cells ratios failed to obtain a 12% mortality reduction. This does not exclude lower mortality rates, which have not been investigated. The use of tranexamic acid in trauma was supported by “high” quality evidence according to the GRADE classification but was downgraded to “moderate” for external validity issues. Conclusions Tranexamic acid is effective in reducing mortality in trauma. The other transfusion practices we investigated have been inadequately studied in the literature, as well as the independent association between mortality and coagulopathy measured with traditional laboratory testing. Overall, in this field of research literature quality is poor.

Published
2016
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49. Comparison of time-series registration methods in breast dynamic infrared imaging.

Author

Riyahi−Alam, S., Agostini, V., Molinari, F., and Knaflitz, M.

Abstract

Automated motion reduction in dynamic infrared imaging is on demand in clinical applications, since movement disarranges time−temperature series of each pixel, thus originating thermal artifacts that might bias the clinical decision. All previously proposed registration methods are feature based algorithms requiring manual intervention. The aim of this work is to optimize the registration strategy specifically for Breast Dynamic Infrared Imaging and to make it user−independent. We implemented and evaluated 3 different 3D time−series registration methods: 1. Linear affine, 2. Non−linear Bspline, 3. Demons applied to 12 datasets of healthy breast thermal images. The results are evaluated through normalized mutual information with average values of 0.70 ±0.03, 0.74 ±0.03 and 0.81 ±0.09 (out of 1) for Affine, Bspline and Demons registration, respectively, as well as breast boundary overlap and Jacobian determinant of the deformation field. The statistical analysis of the results showed that symmetric diffeomorphic Demons' registration method outperforms also with the best breast alignment and non−negative Jacobian values which guarantee image similarity and anatomical consistency of the transformation, due to homologous forces enforcing the pixel geometric disparities to be shortened on all the frames. We propose Demons' registration as an effective technique for time−series dynamic infrared registration, to stabilize the local temperature oscillation. [ABSTRACT FROM AUTHOR]

Published
2015
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