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567 results on '"Aifantis, Iannis"'

2. A RORγt+ cell instructs gut microbiota-specific Treg cell differentiation

Author

Kedmi, Ranit, Najar, Tariq A, Mesa, Kailin R, Grayson, Allyssa, Kroehling, Lina, Hao, Yuhan, Hao, Stephanie, Pokrovskii, Maria, Xu, Mo, Talbot, Jhimmy, Wang, Jiaxi, Germino, Joe, Lareau, Caleb A, Satpathy, Ansuman T, Anderson, Mark S, Laufer, Terri M, Aifantis, Iannis, Bartleson, Juliet M, Allen, Paul M, Paidassi, Helena, Gardner, James M, Stoeckius, Marlon, and Littman, Dan R

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Microbiology, Immunology, Autoimmune Disease, Emerging Infectious Diseases, Digestive Diseases, Infectious Diseases, Vaccine Related, Prevention, Biodefense, 2.1 Biological and endogenous factors, Underpinning research, Aetiology, 1.1 Normal biological development and functioning, Inflammatory and immune system, Oral and gastrointestinal, Cell Differentiation, Dendritic Cells, Gastrointestinal Microbiome, Homeostasis, Immunity, Innate, Integrin alphaV, Nuclear Receptor Subfamily 1, Group F, Member 3, Receptors, CCR7, T-Lymphocytes, Regulatory, Th17 Cells, Transforming Growth Factor beta, Antigen Presentation, Antigen-Presenting Cells, General Science & Technology
Abstract

The mutualistic relationship of gut-resident microbiota and the host immune system promotes homeostasis that ensures maintenance of the microbial community and of a largely non-aggressive immune cell compartment1,2. The consequences of disturbing this balance include proximal inflammatory conditions, such as Crohn's disease, and systemic illnesses. This equilibrium is achieved in part through the induction of both effector and suppressor arms of the adaptive immune system. Helicobacter species induce T regulatory (Treg) and T follicular helper (TFH) cells under homeostatic conditions, but induce inflammatory T helper 17 (TH17) cells when induced Treg (iTreg) cells are compromised3,4. How Helicobacter and other gut bacteria direct T cells to adopt distinct functions remains poorly understood. Here we investigated the cells and molecular components required for iTreg cell differentiation. We found that antigen presentation by cells expressing RORγt, rather than by classical dendritic cells, was required and sufficient for induction of Treg cells. These RORγt+ cells-probably type 3 innate lymphoid cells and/or Janus cells5-require the antigen-presentation machinery, the chemokine receptor CCR7 and the TGFβ activator αv integrin. In the absence of any of these factors, there was expansion of pathogenic TH17 cells instead of iTreg cells, induced by CCR7-independent antigen-presenting cells. Thus, intestinal commensal microbes and their products target multiple antigen-presenting cells with pre-determined features suited to directing appropriate T cell differentiation programmes, rather than a common antigen-presenting cell that they endow with appropriate functions.

Published
2022

3. NUDT21 limits CD19 levels through alternative mRNA polyadenylation in B cell acute lymphoblastic leukemia

Author

Witkowski, Matthew T, Lee, Soobeom, Wang, Eric, Lee, Anna K, Talbot, Alexis, Ma, Chao, Tsopoulidis, Nikolaos, Brumbaugh, Justin, Zhao, Yaqi, Roberts, Kathryn G, Hogg, Simon J, Nomikou, Sofia, Ghebrechristos, Yohana E, Thandapani, Palaniraja, Mullighan, Charles G, Hochedlinger, Konrad, Chen, Weiqiang, Abdel-Wahab, Omar, Eyquem, Justin, and Aifantis, Iannis

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Childhood Leukemia, Orphan Drug, Pediatric Cancer, Hematology, Biotechnology, Pediatric Research Initiative, Stem Cell Research - Nonembryonic - Human, Immunization, Stem Cell Research, Human Genome, Pediatric, Genetics, Vaccine Related, Rare Diseases, Cancer, Aetiology, 2.1 Biological and endogenous factors, Antigens, CD19, Burkitt Lymphoma, Cleavage And Polyadenylation Specificity Factor, Humans, Immunotherapy, Adoptive, Lymphoma, B-Cell, Membrane Glycoproteins, Polyadenylation, Precursor Cell Lymphoblastic Leukemia-Lymphoma, RNA, Messenger, Receptors, Chimeric Antigen, Trans-Activators, Biochemistry and cell biology
Abstract

B cell progenitor acute lymphoblastic leukemia (B-ALL) treatment has been revolutionized by T cell-based immunotherapies-including chimeric antigen receptor T cell therapy (CAR-T) and the bispecific T cell engager therapeutic, blinatumomab-targeting surface glycoprotein CD19. Unfortunately, many patients with B-ALL will fail immunotherapy due to 'antigen escape'-the loss or absence of leukemic CD19 targeted by anti-leukemic T cells. In the present study, we utilized a genome-wide CRISPR-Cas9 screening approach to identify modulators of CD19 abundance on human B-ALL blasts. These studies identified a critical role for the transcriptional activator ZNF143 in CD19 promoter activation. Conversely, the RNA-binding protein, NUDT21, limited expression of CD19 by regulating CD19 messenger RNA polyadenylation and stability. NUDT21 deletion in B-ALL cells increased the expression of CD19 and the sensitivity to CD19-specific CAR-T and blinatumomab. In human B-ALL patients treated with CAR-T and blinatumomab, upregulation of NUDT21 mRNA coincided with CD19 loss at disease relapse. Together, these studies identify new CD19 modulators in human B-ALL.

Published
2022

5. Oncogenic drivers dictate immune control of acute myeloid leukemia

Author

Austin, Rebecca J., Straube, Jasmin, Halder, Rohit, Janardhanan, Yashaswini, Bruedigam, Claudia, Witkowski, Matthew, Cooper, Leanne, Porter, Amy, Braun, Matthias, Souza-Fonseca-Guimaraes, Fernando, Minnie, Simone A., Cooper, Emily, Jacquelin, Sebastien, Song, Axia, Bald, Tobias, Nakamura, Kyohei, Hill, Geoffrey R., Aifantis, Iannis, Lane, Steven W., and Bywater, Megan J.

Published
2023
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6. Mechanisms of Resistance to Noncovalent Brutons Tyrosine Kinase Inhibitors.

Author

Wang, Eric, Mi, Xiaoli, Thompson, Meghan, Montoya, Skye, Notti, Ryan, Afaghani, Jumana, Durham, Benjamin, Penson, Alex, Witkowski, Matthew, Lu, Sydney, Bourcier, Jessie, Hogg, Simon, Erickson, Caroline, Cui, Dan, Cho, Hana, Singer, Michael, Totiger, Tulasigeri, Chaudhry, Sana, Geyer, Mark, Alencar, Alvaro, Linley, Adam, Palomba, M, Coombs, Catherine, Park, Jae, Zelenetz, Andrew, Roeker, Lindsey, Rosendahl, Mary, Tsai, Donald, Ebata, Kevin, Brandhuber, Barbara, Hyman, David, Aifantis, Iannis, Mato, Anthony, Taylor, Justin, and Abdel-Wahab, Omar

Subjects
Humans, Middle Aged, Adenine, Agammaglobulinaemia Tyrosine Kinase, Drug Resistance, Neoplasm, Leukemia, Lymphocytic, Chronic, B-Cell, Mutation, Phospholipase C gamma, Piperidines, Protein Kinase Inhibitors, Receptors, Antigen, B-Cell, Sequence Analysis, RNA, Signal Transduction
Abstract

BACKGROUND: Covalent (irreversible) Brutons tyrosine kinase (BTK) inhibitors have transformed the treatment of multiple B-cell cancers, especially chronic lymphocytic leukemia (CLL). However, resistance can arise through multiple mechanisms, including acquired mutations in BTK at residue C481, the binding site of covalent BTK inhibitors. Noncovalent (reversible) BTK inhibitors overcome this mechanism and other sources of resistance, but the mechanisms of resistance to these therapies are currently not well understood. METHODS: We performed genomic analyses of pretreatment specimens as well as specimens obtained at the time of disease progression from patients with CLL who had been treated with the noncovalent BTK inhibitor pirtobrutinib. Structural modeling, BTK-binding assays, and cell-based assays were conducted to study mutations that confer resistance to noncovalent BTK inhibitors. RESULTS: Among 55 treated patients, we identified 9 patients with relapsed or refractory CLL and acquired mechanisms of genetic resistance to pirtobrutinib. We found mutations (V416L, A428D, M437R, T474I, and L528W) that were clustered in the kinase domain of BTK and that conferred resistance to both noncovalent BTK inhibitors and certain covalent BTK inhibitors. Mutations in BTK or phospholipase C gamma 2 (PLCγ2), a signaling molecule and downstream substrate of BTK, were found in all 9 patients. Transcriptional activation reflecting B-cell-receptor signaling persisted despite continued therapy with noncovalent BTK inhibitors. CONCLUSIONS: Resistance to noncovalent BTK inhibitors arose through on-target BTK mutations and downstream PLCγ2 mutations that allowed escape from BTK inhibition. A proportion of these mutations also conferred resistance across clinically approved covalent BTK inhibitors. These data suggested new mechanisms of genomic escape from established covalent and novel noncovalent BTK inhibitors. (Funded by the American Society of Hematology and others.).

Published
2022

8. A membrane-associated MHC-I inhibitory axis for cancer immune evasion

Author

Chen, Xufeng, Lu, Qiao, Zhou, Hua, Liu, Jia, Nadorp, Bettina, Lasry, Audrey, Sun, Zhengxi, Lai, Baoling, Rona, Gergely, Zhang, Jiangyan, Cammer, Michael, Wang, Kun, Al-Santli, Wafa, Ciantra, Zoe, Guo, Qianjin, You, Jia, Sengupta, Debrup, Boukhris, Ahmad, Zhang, Hongbing, Liu, Cheng, Cresswell, Peter, Dahia, Patricia L.M., Pagano, Michele, Aifantis, Iannis, and Wang, Jun

Published
2023
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9. An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia

Author

Lasry, Audrey, Nadorp, Bettina, Fornerod, Maarten, Nicolet, Deedra, Wu, Huiyun, Walker, Christopher J., Sun, Zhengxi, Witkowski, Matthew T., Tikhonova, Anastasia N., Guillamot-Ruano, Maria, Cayanan, Geraldine, Yeaton, Anna, Robbins, Gabriel, Obeng, Esther A., Tsirigos, Aristotelis, Stone, Richard M., Byrd, John C., Pounds, Stanley, Carroll, William L., Gruber, Tanja A., Eisfeld, Ann-Kathrin, and Aifantis, Iannis

Published
2023
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11. Deep Learning and Pathomics Analyses Reveal Cell Nuclei as Important Features for Mutation Prediction of BRAF-Mutated Melanomas

Author

Kim, Randie H., Nomikou, Sofia, Coudray, Nicolas, Jour, George, Dawood, Zarmeena, Hong, Runyu, Esteva, Eduardo, Sakellaropoulos, Theodore, Donnelly, Douglas, Moran, Una, Hatzimemos, Aristides, Weber, Jeffrey S., Razavian, Narges, Aifantis, Iannis, Fenyo, David, Snuderl, Matija, Shapiro, Richard, Berman, Russell S., Osman, Iman, and Tsirigos, Aristotelis

Published
2022
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14. CHD7 and Runx1 interaction provides a braking mechanism for hematopoietic differentiation

Author

Hsu, Jingmei, Huang, Hsuan-Ting, Lee, Chung-Tsai, Choudhuri, Avik, Wilson, Nicola K., Abraham, Brian J., Moignard, Victoria, Kucinski, Iwo, Yu, Shuqian, Hyde, R. Katherine, Tober, Joanna, Cai, Xiongwei, Li, Yan, Guo, Yalin, Yang, Song, Superdock, Michael, Trompouki, Eirini, Calero-Nieto, Fernando J., Ghamari, Alireza, Jiang, Jing, Gao, Peng, Gao, Long, Nguyen, Vy, Robertson, Anne L., Durand, Ellen M., Kathrein, Katie L., Aifantis, Iannis, Gerber, Scott A., Tong, Wei, Tan, Kai, Cantor, Alan B., Zhou, Yi, Liu, P. Paul, Young, Richard A., Göttgens, Berthold, Speck, Nancy A., and Zon, Leonard I.

Published
2020

16. BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells

Author

Valls, Ester, Lobry, Camille, Geng, Huimin, Wang, Ling, Cardenas, Mariano, Rivas, Martín, Cerchietti, Leandro, Oh, Philmo, Yang, Shao Ning, Oswald, Erin, Graham, Camille W, Jiang, Yanwen, Hatzi, Katerina, Agirre, Xabier, Perkey, Eric, Li, Zhuoning, Tam, Wayne, Bhatt, Kamala, Leonard, John P, Zweidler-McKay, Patrick A, Maillard, Ivan, Elemento, Olivier, Ci, Weimin, Aifantis, Iannis, and Melnick, Ari

Subjects
Rare Diseases, Hematology, Genetics, Cancer, HIV/AIDS, Lymphoma, 2.1 Biological and endogenous factors, Aetiology, Good Health and Well Being, Animals, B-Lymphocytes, Gene Expression Regulation, Neoplastic, Germinal Center, Heterografts, Humans, Lymphoma, Follicular, Mice, Mice, SCID, Proto-Oncogene Proteins c-bcl-6, Receptor, Notch2, Oncology and Carcinogenesis
Abstract

Although the BCL6 transcriptional repressor is frequently expressed in human follicular lymphomas (FL), its biological role in this disease remains unknown. Herein, we comprehensively identify the set of gene promoters directly targeted by BCL6 in primary human FLs. We noted that BCL6 binds and represses NOTCH2 and NOTCH pathway genes. Moreover, BCL6 and NOTCH2 pathway gene expression is inversely correlated in FL. Notably, BCL6 upregulation is associated with repression of NOTCH2 and its target genes in primary human and murine germinal center (GC) cells. Repression of NOTCH2 is an essential function of BCL6 in FL and GC B cells because inducible expression of Notch2 abrogated GC formation in mice and killed FL cells. Indeed, BCL6-targeting compounds or gene silencing leads to the induction of NOTCH2 activity and compromises survival of FL cells, whereas NOTCH2 depletion or pathway antagonists rescue FL cells from such effects. Moreover, BCL6 inhibitors induced NOTCH2 expression and suppressed growth of human FL xenografts in vivo and primary human FL specimens ex vivo These studies suggest that established FLs are thus dependent on BCL6 through its suppression of NOTCH2Significance: We show that human FLs are dependent on BCL6, and primary human FLs can be killed using specific BCL6 inhibitors. Integrative genomics and functional studies of BCL6 in primary FL cells point toward a novel mechanism whereby BCL6 repression of NOTCH2 drives the survival and growth of FL cells as well as GC B cells, which are the FL cell of origin. Cancer Discov; 7(5); 506-21. ©2017 AACR.This article is highlighted in the In This Issue feature, p. 443.

Published
2017

17. Author Correction: An inflammatory state remodels the immune microenvironment and improves risk stratification in acute myeloid leukemia

Author

Lasry, Audrey, Nadorp, Bettina, Fornerod, Maarten, Nicolet, Deedra, Wu, Huiyun, Walker, Christopher J., Sun, Zhengxi, Witkowski, Matthew T., Tikhonova, Anastasia N., Guillamot-Ruano, Maria, Cayanan, Geraldine, Yeaton, Anna, Robbins, Gabriel, Obeng, Esther A., Tsirigos, Aristotelis, Stone, Richard M., Byrd, John C., Pounds, Stanley, Carroll, William L., Gruber, Tanja A., Eisfeld, Ann-Kathrin, and Aifantis, Iannis

Published
2023
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20. Active and Inactive Enhancers Cooperate to Exert Localized and Long-Range Control of Gene Regulation.

Author

Proudhon, Charlotte, Snetkova, Valentina, Raviram, Ramya, Lobry, Camille, Badri, Sana, Jiang, Tingting, Hao, Bingtao, Trimarchi, Thomas, Kluger, Yuval, Aifantis, Iannis, Bonneau, Richard, and Skok, Jane A

Subjects
T-Lymphocytes, Animals, Mice, Inbred C57BL, Receptors, Antigen, T-Cell, alpha-beta, RNA, Messenger, Gene Rearrangement, beta-Chain T-Cell Antigen Receptor, Gene Expression Regulation, Protein Binding, Enhancer Elements, Genetic, Igk, Tcrb, enhancer-sharing, gene regulation, localized and long-range contacts, nuclear architecture, super-enhancer, transcription factor binding, transcriptional output, Mice, Inbred C57BL, Receptors, Antigen, T-Cell, alpha-beta, RNA, Messenger, Gene Rearrangement, beta-Chain T-Cell Antigen Receptor, Enhancer Elements, Genetic, Biochemistry and Cell Biology, Medical Physiology
Abstract

V(D)J recombination relies on the presence of proximal enhancers that activate the antigen receptor (AgR) loci in a lineage- and stage-specific manner. Unexpectedly, we find that both active and inactive AgR enhancers cooperate to disseminate their effects in a localized and long-range manner. Here, we demonstrate the importance of short-range contacts between active enhancers that constitute an Igk super-enhancer in B cells. Deletion of one element reduces the interaction frequency between other enhancers in the hub, which compromises the transcriptional output of each component. Furthermore, we establish that, in T cells, long-range contact and cooperation between the inactive Igk enhancer MiEκ and the active Tcrb enhancer Eβ alters enrichment of CBFβ binding in a manner that impacts Tcrb recombination. These findings underline the complexities of enhancer regulation and point to a role for localized and long-range enhancer-sharing between active and inactive elements in lineage- and stage-specific control.

Published
2016

21. Publisher Correction: A RORγt+ cell instructs gut microbiota-specific Treg cell differentiation

Author

Kedmi, Ranit, Najar, Tariq A., Mesa, Kailin R., Grayson, Allyssa, Kroehling, Lina, Hao, Yuhan, Hao, Stephanie, Pokrovskii, Maria, Xu, Mo, Talbot, Jhimmy, Wang, Jiaxi, Germino, Joe, Lareau, Caleb A., Satpathy, Ansuman T., Anderson, Mark S., Laufer, Terri M., Aifantis, Iannis, Bartleson, Juliet M., Allen, Paul M., Paidassi, Helena, Gardner, James M., Stoeckius, Marlon, and Littman, Dan R.

Published
2022
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22. Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL

Author

Rodriguez, Sonia, Abundis, Christina, Boccalatte, Francesco, Mehrotra, Purvi, Chiang, Mark Y., Yui, Mary A., Wang, Lin, Zhang, Huajia, Zollman, Amy, Bonfim-Silva, Ricardo, Kloetgen, Andreas, Palmer, Joycelynne, Sandusky, George, Wunderlich, Mark, Kaplan, Mark H., Mulloy, James C., Marcucci, Guido, Aifantis, Iannis, Cardoso, Angelo A., and Carlesso, Nadia

Published
2020
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23. Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia

Author

Kloetgen, Andreas, Thandapani, Palaniraja, Ntziachristos, Panagiotis, Ghebrechristos, Yohana, Nomikou, Sofia, Lazaris, Charalampos, Chen, Xufeng, Hu, Hai, Bakogianni, Sofia, Wang, Jingjing, Fu, Yi, Boccalatte, Francesco, Zhong, Hua, Paietta, Elisabeth, Trimarchi, Thomas, Zhu, Yixing, Van Vlierberghe, Pieter, Inghirami, Giorgio G., Lionnet, Timothee, Aifantis, Iannis, and Tsirigos, Aristotelis

Published
2020
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30. Role of Dysregulated Cytokine Signaling and Bacterial Triggers in the Pathogenesis of Cutaneous T-Cell Lymphoma

Author

Fanok, Melania H., Sun, Amy, Fogli, Laura K., Narendran, Vijay, Eckstein, Miriam, Kannan, Kasthuri, Dolgalev, Igor, Lazaris, Charalampos, Heguy, Adriana, Laird, Mary E., Sundrud, Mark S., Liu, Cynthia, Kutok, Jeff, Lacruz, Rodrigo S., Latkowski, Jo-Ann, Aifantis, Iannis, Ødum, Niels, Hymes, Kenneth B., Goel, Swati, and Koralov, Sergei B.

Published
2018
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32. The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation

Author

Guillamot, Maria, Ouazia, Dahmane, Dolgalev, Igor, Yeung, Stephen T., Kourtis, Nikos, Dai, Yuling, Corrigan, Kate, Zea-Redondo, Luna, Saraf, Anita, Florens, Laurence, Washburn, Michael P., Tikhonova, Anastasia N., Malumbres, Marina, Gong, Yixiao, Tsirigos, Aristotelis, Park, Christopher, Barbieri, Christopher, Khanna, Kamal M., Busino, Luca, and Aifantis, Iannis

Published
2019
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33. The bone marrow microenvironment at single-cell resolution

Author

Tikhonova, Anastasia N., Dolgalev, Igor, Hu, Hai, Sivaraj, Kishor K., Hoxha, Edlira, Cuesta-Domínguez, Álvaro, Pinho, Sandra, Akhmetzyanova, Ilseyar, Gao, Jie, Witkowski, Matthew, Guillamot, Maria, Gutkin, Michael C., Zhang, Yutong, Marier, Christian, Diefenbach, Catherine, Kousteni, Stavroula, Heguy, Adriana, Zhong, Hua, Fooksman, David R., Butler, Jason M., Economides, Aris, Frenette, Paul S., Adams, Ralf H., Satija, Rahul, Tsirigos, Aristotelis, and Aifantis, Iannis

Published
2019
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34. Supplementary Methods from Mitophagy Promotes Resistance to BH3 Mimetics in Acute Myeloid Leukemia

Author

Glytsou, Christina, primary, Chen, Xufeng, primary, Zacharioudakis, Emmanouil, primary, Al-Santli, Wafa, primary, Zhou, Hua, primary, Nadorp, Bettina, primary, Lee, Soobeom, primary, Lasry, Audrey, primary, Sun, Zhengxi, primary, Papaioannou, Dimitrios, primary, Cammer, Michael, primary, Wang, Kun, primary, Zal, Tomasz, primary, Zal, Malgorzata Anna, primary, Carter, Bing Z., primary, Ishizawa, Jo, primary, Tibes, Raoul, primary, Tsirigos, Aristotelis, primary, Andreeff, Michael, primary, Gavathiotis, Evripidis, primary, and Aifantis, Iannis, primary

Published
2023
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35. Supplementary Figures 1-7 from Mitophagy Promotes Resistance to BH3 Mimetics in Acute Myeloid Leukemia

Author

Glytsou, Christina, primary, Chen, Xufeng, primary, Zacharioudakis, Emmanouil, primary, Al-Santli, Wafa, primary, Zhou, Hua, primary, Nadorp, Bettina, primary, Lee, Soobeom, primary, Lasry, Audrey, primary, Sun, Zhengxi, primary, Papaioannou, Dimitrios, primary, Cammer, Michael, primary, Wang, Kun, primary, Zal, Tomasz, primary, Zal, Malgorzata Anna, primary, Carter, Bing Z., primary, Ishizawa, Jo, primary, Tibes, Raoul, primary, Tsirigos, Aristotelis, primary, Andreeff, Michael, primary, Gavathiotis, Evripidis, primary, and Aifantis, Iannis, primary

Published
2023
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36. Flow cytometric assessment of leukemia-associated monocytes in childhood B-cell acute lymphoblastic leukemia outcome

Author

Contreras Yametti, Gloria Paz, primary, Evensen, Nikki A, additional, Schloss, Jennifer, additional, Aldebert, Clemence, additional, Duan, Emily, additional, Zhang, Yan, additional, Hu, Jiyuan, additional, Chambers, Tiffany M, additional, Scheurer, Michael E, additional, Teachey, David T, additional, Rabin, Karen R, additional, Raetz, Elizabeth A., additional, Aifantis, Iannis, additional, Carroll, William L, additional, and Witkowski, Matthew T, additional

Published
2023
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37. A membrane-associated inhibitory axis of MHC-I presentation for cancer immune evasion

Author

Lu, Qiao, primary, Chen, Xufeng, additional, Zhou, Hua, additional, Liu, Jia, additional, Nadorp, Bettina, additional, Lasry, Audrey, additional, Sun, Zhengxi, additional, Zhang, Jiangyan, additional, Cammer, Michael, additional, Wang, Kun, additional, Ciantra, Zoe, additional, You, Jia, additional, Guo, Qianjin, additional, Zhang, Hongbing, additional, Sengupta, Debrup, additional, Boukhris, Ahmad, additional, Liu, Cheng, additional, Cresswell, Peter, additional, Dahia, Patricia L. M., additional, Aifantis, Iannis, additional, and Wang, Jun, additional

Published
2023
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38. Abstract A20: Inflammation remodels the immune microenvironment in acute myeloid leukemia

Author

Lasry, Audrey, primary, Nadorp, Bettina, additional, Fornerod, Maarten, additional, Nicolet, Deedra, additional, Wu, Huiyun, additional, Walker, Christopher J, additional, Sun, Zhengxi, additional, Witkowski, Matthew T, additional, Tikhonova, Anastasia N, additional, Guillamot, Maria, additional, Cayanan, Geraldine, additional, Yeaton, Anna, additional, Gruber, Tanja A, additional, Eisfeld, Ann-Kathrin, additional, and Aifantis, Iannis, additional

Published
2023
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39. Abstract A10: Targeting MHC-I antigen presentation for cancer immune evasion in acute myeloid leukemia

Author

Chen, Xufeng, primary, Lu, Qiao, additional, Zhou, Hua, additional, Liu, Jia, additional, Nadorp, Bettina, additional, Lasry, Audrey, additional, Sun, Zhengxi, additional, Zhang, Jiangyan, additional, Cammer, Michael, additional, Wang, Kun, additional, Ciantra, Zoe, additional, You, Jia, additional, Guo, Qianjin, additional, Zhang, Hongbing, additional, Sengupta, Debrup, additional, Boukhris, Ahmad, additional, Liu, Cheng, additional, Cresswell, Peter, additional, Dahia, Patricia L. M., additional, Wang, Jun, additional, and Aifantis, Iannis, additional

Published
2023
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41. Publisher Correction: The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia

Author

Papaioannou, Dimitrios, Petri, Andreas, Dovey, Oliver M., Terreri, Sara, Wang, Eric, Collins, Frances A., Woodward, Lauren A., Walker, Allison E., Nicolet, Deedra, Pepe, Felice, Kumchala, Prasanthi, Bill, Marius, Walker, Christopher J., Karunasiri, Malith, Mrózek, Krzysztof, Gardner, Miranda L., Camilotto, Virginia, Zitzer, Nina, Cooper, Jonathan L., Cai, Xiongwei, Rong-Mullins, Xiaoqing, Kohlschmidt, Jessica, Archer, Kellie J., Freitas, Michael A., Zheng, Yi, Lee, Robert J., Aifantis, Iannis, Vassiliou, George, Singh, Guramrit, Kauppinen, Sakari, Bloomfield, Clara D., Dorrance, Adrienne M., and Garzon, Ramiro

Published
2020
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42. The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia

Author

Papaioannou, Dimitrios, Petri, Andreas, Dovey, Oliver M., Terreri, Sara, Wang, Eric, Collins, Frances A., Woodward, Lauren A., Walker, Allison E., Nicolet, Deedra, Pepe, Felice, Kumchala, Prasanthi, Bill, Marius, Walker, Christopher J., Karunasiri, Malith, Mrózek, Krzysztof, Gardner, Miranda L., Camilotto, Virginia, Zitzer, Nina, Cooper, Jonathan L., Cai, Xiongwei, Rong-Mullins, Xiaoqing, Kohlschmidt, Jessica, Archer, Kellie J., Freitas, Michael A., Zheng, Yi, Lee, Robert J., Aifantis, Iannis, Vassiliou, George, Singh, Guramrit, Kauppinen, Sakari, Bloomfield, Clara D., Dorrance, Adrienne M., and Garzon, Ramiro

Published
2019
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44. Oncogenic hijacking of the stress response machinery in T cell acute lymphoblastic leukemia

Author

Kourtis, Nikos, Lazaris, Charalampos, Hockemeyer, Kathryn, Balandrán, Juan Carlos, Jimenez, Alejandra R., Mullenders, Jasper, Gong, Yixiao, Trimarchi, Thomas, Bhatt, Kamala, Hu, Hai, Shrestha, Liza, Ambesi-Impiombato, Alberto, Kelliher, Michelle, Paietta, Elisabeth, Chiosis, Gabriela, Guzman, Monica L., Ferrando, Adolfo A., Tsirigos, Aristotelis, and Aifantis, Iannis

Published
2018
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45. Mitophagy promotes resistance to BH3 mimetics in acute myeloid leukemia

Author

Glytsou, Christina, primary, Chen, Xufeng, additional, Zacharioudakis, Emmanouil, additional, Al-Santli, Wafa, additional, Zhou, Hua, additional, Nadorp, Bettina, additional, Lee, Soobeom, additional, Lasry, Audrey, additional, Sun, Zhengxi, additional, Papaioannou, Dimitrios, additional, Cammer, Michael, additional, Wang, Kun, additional, Zal, Tomasz, additional, Zal, Malgorzata Anna., additional, Carter, Bing Z., additional, Ishizawa, Jo, additional, Tibes, Raoul, additional, Tsirigos, Aristotelis, additional, Andreeff, Michael, additional, Gavathiotis, Evripidis, additional, and Aifantis, Iannis, additional

Published
2023
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48. Data from The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation

Author

Yeaton, Anna, primary, Cayanan, Geraldine, primary, Loghavi, Sanam, primary, Dolgalev, Igor, primary, Leddin, Emmett M., primary, Loo, Christian E., primary, Torabifard, Hedieh, primary, Nicolet, Deedra, primary, Wang, Jingjing, primary, Corrigan, Kate, primary, Paraskevopoulou, Varvara, primary, Starczynowski, Daniel T, primary, Wang, Eric, primary, Abdel-Wahab, Omar, primary, Viny, Aaron D, primary, Stone, Richard M., primary, Byrd, John C., primary, Guryanova, Olga A., primary, Kohli, Rahul M., primary, Cisneros, G. Andrés, primary, Tsirigos, Aristotelis, primary, Eisfeld, Ann-Kathrin, primary, Aifantis, Iannis, primary, and Guillamot, Maria, primary

Published
2023
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49. Supplementary Figure from The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation

Author

Yeaton, Anna, primary, Cayanan, Geraldine, primary, Loghavi, Sanam, primary, Dolgalev, Igor, primary, Leddin, Emmett M., primary, Loo, Christian E., primary, Torabifard, Hedieh, primary, Nicolet, Deedra, primary, Wang, Jingjing, primary, Corrigan, Kate, primary, Paraskevopoulou, Varvara, primary, Starczynowski, Daniel T, primary, Wang, Eric, primary, Abdel-Wahab, Omar, primary, Viny, Aaron D, primary, Stone, Richard M., primary, Byrd, John C., primary, Guryanova, Olga A., primary, Kohli, Rahul M., primary, Cisneros, G. Andrés, primary, Tsirigos, Aristotelis, primary, Eisfeld, Ann-Kathrin, primary, Aifantis, Iannis, primary, and Guillamot, Maria, primary

Published
2023
Full Text
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50. Supplementary Data from The Impact of Inflammation-Induced Tumor Plasticity during Myeloid Transformation

Author

Yeaton, Anna, primary, Cayanan, Geraldine, primary, Loghavi, Sanam, primary, Dolgalev, Igor, primary, Leddin, Emmett M., primary, Loo, Christian E., primary, Torabifard, Hedieh, primary, Nicolet, Deedra, primary, Wang, Jingjing, primary, Corrigan, Kate, primary, Paraskevopoulou, Varvara, primary, Starczynowski, Daniel T, primary, Wang, Eric, primary, Abdel-Wahab, Omar, primary, Viny, Aaron D, primary, Stone, Richard M., primary, Byrd, John C., primary, Guryanova, Olga A., primary, Kohli, Rahul M., primary, Cisneros, G. Andrés, primary, Tsirigos, Aristotelis, primary, Eisfeld, Ann-Kathrin, primary, Aifantis, Iannis, primary, and Guillamot, Maria, primary

Published
2023
Full Text
View/download PDF

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