361 results on '"Akpalu, Albert"'
Search Results
2. Mucuna pruriens to treat Parkinson's disease in low-income countries: Recommendations and practical guidelines from the farmer to clinical trials. Paving the way for future use in clinical practice
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Caronni, Serena, Del Sorbo, Francesca, Barichella, Michela, Fothergill-Misbah, Natasha, Denne, Tanya, Laguna, Janeth, Urasa, Sarah, Dekker, Marieke C.J., Akpalu, Albert, Sarfo, Fred Stephen, Cham, Momodou, Pezzoli, Gianni, and Cilia, Roberto
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- 2024
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3. Dementia in Africa: Current evidence, knowledge gaps, and future directions
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Akinyemi, Rufus O, Yaria, Joseph, Ojagbemi, Akin, Guerchet, Maëlenn, Okubadejo, Njideka, Njamnshi, Alfred K, Sarfo, Fred S, Akpalu, Albert, Ogbole, Godwin, Ayantayo, Temitayo, Adokonou, Thierry, Paddick, Stella‐Maria, Ndetei, David, Bosche, Judith, Ayele, Biniyam, Damas, Andrea, Coker, Motunrayo, Mbakile‐Mahlanza, Lingani, Ranchod, Kirti, Bobrow, Kirsten, Anazodo, Udunna, Damasceno, Albertino, Seshadri, Sudha, Pericak‐Vance, Margaret, Lawlor, Brian, Miller, Bruce L, Owolabi, Mayowa, Baiyewu, Olusegun, Walker, Richard, Gureje, Oye, Kalaria, Rajesh N, Ogunniyi, Adesola, and Consortium, the African Dementia
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Biomedical and Clinical Sciences ,Neurosciences ,Clinical Sciences ,Clinical Research ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Acquired Cognitive Impairment ,Alzheimer's Disease ,Genetics ,Aging ,Brain Disorders ,Dementia ,Neurodegenerative ,Neurological ,Good Health and Well Being ,Aged ,Alzheimer Disease ,Apolipoprotein E4 ,Dementia ,Vascular ,Genome-Wide Association Study ,Genotype ,Humans ,Africa ,Alzheimer's disease ,consortium ,dementia ,epidemiology ,genetics ,neuropathology ,biomarkers ,precision medicine ,vascular dementia ,African Dementia Consortium ,neuropathology. biomarkers ,Geriatrics ,Clinical sciences ,Biological psychology - Abstract
In tandem with the ever-increasing aging population in low and middle-income countries, the burden of dementia is rising on the African continent. Dementia prevalence varies from 2.3% to 20.0% and incidence rates are 13.3 per 1000 person-years with increasing mortality in parts of rapidly transforming Africa. Differences in nutrition, cardiovascular factors, comorbidities, infections, mortality, and detection likely contribute to lower incidence. Alzheimer's disease, vascular dementia, and human immunodeficiency virus/acquired immunodeficiency syndrome-associated neurocognitive disorders are the most common dementia subtypes. Comprehensive longitudinal studies with robust methodology and regional coverage would provide more reliable information. The apolipoprotein E (APOE) ε4 allele is most studied but has shown differential effects within African ancestry compared to Caucasian. More candidate gene and genome-wide association studies are needed to relate to dementia phenotypes. Validated culture-sensitive cognitive tools not influenced by education and language differences are critically needed for implementation across multidisciplinary groupings such as the proposed African Dementia Consortium.
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- 2022
4. Stroke occurrence by hypertension treatment status in Ghana and Nigeria: A case-control study
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Sarfo, Fred Stephen, Asowata, Osahon Jeffery, Akpa, Onoja Matthew, Akinyemi, Joshua, Wahab, Kolawole, Singh, Arti, Akpalu, Albert, Opare-Addo, Priscilla Abrafi, Okekunle, Akinkunmi Paul, Ogbole, Godwin, Fakunle, Adekunle, Adebayo, Oladimeji, Obiako, Reginald, Akisanya, Cynthia, Komolafe, Morenkeji, Olunuga, Taiwo, Chukwuonye, Innocent I., Osaigbovo, Godwin, Olowoyo, Paul, Adebayo, Phillip B., Jenkins, Carolyn, Bello, Abiodun, Laryea, Ruth, Ibinaye, Phillip, Olalusi, Olatundun, Adeniyi, Sunday, Arulogun, Oyedunni, Ogah, Okechukwu, Adeoye, Abiodun, Samuel, Dialla, Calys-Tagoe, Benedit, Tiwari, Hemant, Obiageli, Onyemelukwe, Mensah, Yaw, Appiah, Lambert, Akinyemi, Rufus, Ovbiagele, Bruce, and Owolabi, Mayowa
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- 2024
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5. Clinical and neuroimaging factors associated with 30-day fatality among indigenous West Africans with spontaneous intracerebral hemorrhage
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Komolafe, Morenikeji A., Sunmonu, Taofiki, Akinyemi, Joshua, Sarfo, Fred S., Akpalu, Albert, Wahab, Kolawole, Obiako, Reginald, Owolabi, Lukman, Osaigbovo, Godwin O., Ogbole, Godwin, Tiwari, Hemant K., Jenkins, Carolyn, Lackland, Daniel T., Fakunle, Adekunle G., Uvere, Ezinne, Akpa, Onoja, Dambatta, Hamisu A., Akpalu, Josephine, Onasanya, Akinola, Olaleye, Adeniji, Ogah, Okechukwu S., Isah, Sulaiman Y., Fawale, Micheal B., Adebowale, Akintunde, Okekunle, Akinkunmi P., Arnett, Donna, Adeoye, Abiodun M., Agunloye, Atinuke M., Bello, Abiodun H., Aderibigbe, Adeniyi S., Idowu, Ahmed O., Sanusi, Ahmad A., Ogunmodede, Adebimpe, Balogun, Simon A., Egberongbe, Adedeji A., Rotimi, Folorunso T., Fredrick, Adeyemi, Akinnuoye, Andrew O., Adeniyi, Folu A., Calys-Tagoe, Benedict, Adebayo, Philip, Arulogun, Oyedunni, Agbogu-Ike, Obiageli U., Yaria, Joseph, Appiah, Lambert, Ibinaiye, Philip, Singh, Arti, Adeniyi, Sunday, Olalusi, Oladotun, Mande, Aliyu, Balogun, Olayemi, Akinyemi, Rufus, Ovbiagele, Bruce, and Owolabi, Mayowa
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- 2024
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6. Pragmatic solutions to reduce the global burden of stroke: a World Stroke Organization–Lancet Neurology Commission
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Feigin, Valery L, Abd-Allah, Foad, Akinyemi, Rufus O, Bhattacharjee, Natalia V, Brainin, Michael, Cao, Jackie, Caso, Valeria, Dalton, Bronte, Davis, Alan, Dempsey, Robert, Duprey, Joseph, Feng, Wuwei, Ford, Gary A, Gall, Seana, Gandhi, Dorcas, Good, David C, Hachinski, Vladimir, Hacke, Werner, Hankey, Graeme J, Ishida, Marie, Johnson, Walter, Kim, Julie, Lavados, Pablo, Lindsay, Patrice, Mahal, Ajay, Martins, Sheila, Murray, Christopher, Nguyen, Thuy Phuong, Norrving, Bo, Olaiya, Muideen T, Olalusi, Oladotun V, Pandian, Jeyaraj, Phan, Hoang, Platz, Thomas, Ranta, Anna, Rehman, Sabah, Roth, Greg, Sebastian, Ivy Anne, Smith, Amanda E, Suwanwela, Nijasri C, Sylaja, P N, Thapa, Rajshree, Thrift, Amanda G, Uvere, Ezinne, Vollset, Stein Emil, Yavagal, Dileep, Yaria, Joseph, Owolabi, Mayowa O, Abera, Semaw Ferede, Akinyemi, Rufus, Dempsey, Robert J, Ibrahim, Norlinah Mohamed, Liu, Liping, Ovbiagele, Bruce, Piradov, Michael, Suwanwela, Nijasri, Abanto, Carlos, Addissie, Adamu, Adeleye, Amos O, Adilbekov, Yerzhan, Adilbekova, Bibigul, Adoukonou, Thierry A, Aguiar de Sousa, Diana, Akhmetzhanova, Zauresh, Akpalu, Albert, El Alaoui-Faris, Mustapha, Ameriso, Sebastian F, Andonova, Silva, Arsovska, Anita, Awoniyi, Folorunso E, Bakhiet, Moiz, Barboza, Miguel A, Basri, Hamidon, Bath, Philip M, Bereczki, Daniel, Beretta, Simone, Berkowitz, Aaron L, Bernhardt, Julie, Berzina, Guna, Bhavsar, Bhavan, Bisharyan, Mher S, Bohara, Manoj, Bovet, Pascal, Budincevic, Hrvoje, Cadilhac, Dominique A, Čerimagić, Denis, Charway-Felli, Augustina, Chen, Christopher, Chin, Jerome H, Christensen, Hanne, Chwojnicki, Kamil, Conforto, Adriana B, Correia, Manuel, Mora Cuervo, Daissy L, Członkowska, Anna, D'Amelio, Marco, Danielyan, Kristine E, Davis, Stephen, Demarin, Vida, Demchuk, Andrew M, Dichgans, Martin, Dokova, Klara, Donnan, Geoffrey, Duran, Juan Carlos, Ekeng, Gloria, Elkind, Mitchell S, Endres, Matthias, Fischer, Urs, Flomin, Yuriy, Gankpe, Fortuné, Gavidia, Martin, Gaye Saavedra, Andrés, Gebreyohanns, Mehari, George, Mary, Gierlotka, Marek, Giroud, Maurice, Gnedovskaya, Elena V, Gonçalves, Ivete Pillo, Gongora-Rivera, Fernando, Gunaratne, Padma S, Hamadeh, Randah R, Hamzat, Tal-hatu K, Heldner, Mirjam R, Ibrahim, Etedal, Ihle-Hansen, Hanne, Jee, Sungju, Jiann-Shing, Jeng, Johnston, S Clay, Jovanovic, Dejana, Jurjāns, Kristaps, Kalani, Rizwan, Kalkonde, Yogeshwar, Kamenova, Saltanat, Karaszewski, Bartosz, Kelly, Peter, Kiechl, Stefan, Kondybayeva, Aida, Kõrv, Janika, Kozera, Grzegorz, Kravchenko, Michael, Krespi, Yakup, Krishnamurthi, Rita, Kruja, Jera, Kutluk, Kursad, Langhorne, Peter, Law, Zhe K, Lebedynets, Dmytro, Lee, Tsong-Hai, Leung, Thomas W, Liebeskind, David S, López-Jaramillo, Patricio, Lotufo, Paulo A, Machline-Carrion, M Julia, Maia, Luis F, Malojcic, Branko, Markus, Hugh S, Marquez-Romero, Juan M, Medina, Marco T, Medukhanova, Sabina, Mehndiratta, Man Mohan, Miglāne, Evija, Mihejeva, Illa, Mikulik, Robert, Mirrakhimov, Erkin, Mohl, Stephanie, Munakomi, Sunil, Murphy, Sean, Musa, Kamarul I, Nasreldein, Ahmed, Nogueira, Raul G, Nolte, Christian H, Noubiap, Jean Jacques, Novarro-Escudero, Nelson, Ocampo, Cassandra, O'Donnell, Martin, Ogun, Yomi, Ogunniyi, Adesola, Oraby, Mohammed I, Ōrken, Dilek N, Ōzdemir, Atilla O, Ozturk, Serefnur, Paccot, Mélanie, Pereira, Telmo, Peeters, André, Potpara, Tatjana, Proios, Hariklia, Rathore, Farooq A, Sacco, Ralph L, Sahathevan, Ramesh, Sandset, Else S, Renato Santos, Irving, Saposnik, Gustavo, Sarfo, Fred S, Sargento-Freitas, João, Sharma, Mukul, Shaw, Louise, Sheth, Kevin N, Shin, Yong-Il, Shobhana, A, Silva, S Nishan, Tedim Cruz, Vitor, Thakur, Kiran, Thapa, Lekh Jung, Toni, Danilo, Topcuoglu, Mehmetakif A, Torales, Julio, Towfighi, Amytis, Truelsen, Thomas, Tsiskaridze, Alexander, Tulloch-Reid, Marshall, Useche, Juan N, Vanacker, Peter, Vassilopoulou, Sophia, Vukorepa, Gorana, Vuletic, Vladimira, Wahab, Kolawole W, Wang, Wenzhi, Wijeratne, Tissa, Wojtyniak, Bogdan, Wolfe, Charles, Yacouba, Mapoure N, Yang, Jie, Yifru, Yared M, Yock-Corrales, Adriana, Yonemoto, Naohiro, Yperzeele, Laetitia, and Zagożdżon, Pawel
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- 2023
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7. Identification of genetic risk loci and causal insights associated with Parkinson's disease in African and African admixed populations: a genome-wide association study
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Okubadejo, Njideka, Ojo, Oluwadamilola, Abiodun, Oladunni, Achoru, Charles, Agabi, Osigwe, Agulanna, Uchechi, Akinyemi, Rufus, Ali, Mohammed, Ani-Osheku, Ifeyinwa, Arigbodi, Ohwotemu, Bello, Abiodun, Erameh, Cyril, Farombi, Temitope, Fawale, Michael, Imarhiagbe, Frank, Iwuozo, Emmanuel, Komolafe, Morenikeji, Nwani, Paul, Nwazor, Ernest, Nyandaiti, Yakub, Obiabo, Yahaya, Odeniyi, Olanike, Odiase, Francis, Ojini, Francis, Onwuegbuzie, Gerald, Osaigbovo, Godwin, Osemwegie, Nosakhare, Oshinaike, Olajumoke, Otubogun, Folajimi, Oyakhire, Shyngle, Ozomma, Simon, Samuel, Sarah, Taiwo, Funmilola, Wahab, Kolawole, Zubair, Yusuf, Gams Massi, Daniel, Gueumekane Bila lamou, Eric, Njamnshi Nfor, Leonard, Magnerou, Mélanie Annick, Fogang Fogoum, Yannick, Shalash, Ali, El-FawaI, Hassan, Khedr, Eman, Fawi, Gharib, A. Eltantawi, Mohamed, Salama, Mohamed, El-Jaafary, Shaimaa, Hamed, Sharifa, Tafesse Mengesha, Abenet, Alemayehu Ayele, Biniyam, Melka Oda, Dereje, Zenebe Zewde, Yared, Debebe Gelan, Yohanesse, AkpaIu, Albert, Charway-Felli, Augustina, Stephen Sarfo, Fred, Adjei, Patrick, Obese, Vida, Bocoum, Abdoulaye, Koita, Abdou, Oumar Guinto, Cheick, Coulibaly, Toumany, Maiga, Youssoufa, Kone, Zaynab, Bell, Abiodun, Adebowale, Akintunde A., Akpekpe, John, lyagba, Alagoma, Wulgo, Ali Mohammed, Arabambi, Babawale, Agu, Christian, Dike, Franklin, Ishola, Ismail, Abiodun, Kehinde, Ekenze, Oluchi, Agabi Osigwe, Paul, Balarabe, Salisu, Abubakar, Sani, Williams, Uduak, Fall, Maouly, Mamadou Diop, Alassane, Hilaire Dominique, Ewodo Touna, Mochan, Andre, Modi, Girish, Dindayal, Saiesha, Ali Awadelkareem, Eman, Elsayed, Inas, Dahawi, Maha, Awadelkareem, Mosab Ali, Misbah, Sarah, Mushengez, Brighton, Kimambo, Henrika, Msango, Leonard, Adebayo, Philip, OKeng, Kigocha, Diekker, Marieke, URassa, Sarah, Gouider, Riadh, Ben Djebara, Mouna, Gargouri, Amina, Kacem, Imen, Nasri, Amina, Mrabet, Saloua, Sghaier, Ikram, Mkada, Imen, Atadzhanov, Masharip, Chishimba, Lorraine, Rizig, Mie, Jama, Fatumah, Okunoye, Olaitan, Hardy, John, Houlden, Henry, Singleton, Andrew, Nalls, Mike, Shamim, Ejaz, Jonas, Cabell, Williamson, Jared, Hall, Deborah A., Rosenbaum, Marc, Davis, Staci, Dean, Marissa, Cromer, Candace, Smith, Jenna, Ruffrage, Lauren, Richardson, Joseph, Sipma, Rebeka, Xie, Tao, Padmanaban, Manesh, Warren, Natalie, Mercado, Tomas, Disbrow, Elizabeth, Chauppeta, Brian, Thomas-Dean, Fermine, Toms, Jamie, Lofton, Katelyn, Rawls, Ashley, Rizer, Kyle, Black, Nieci, Solle, Justin, O'Grady, Alyssa, Sherer, Todd, Fiske, Brian, Başak, A. Nazlı, Tan, Ai Huey, Noyce, Alastair, Akpalu, Albert, Espay, Alberto, Martínez-Carrasco, Alejandro, Medina, Alex, Zimprich, Alexander, Brice, Alexis, Karimova, Altynay, Hernandez, Alvaro, Illarionova, Anastasia, Quattrone, Andrea, Singleton, Andrew B, Sobering, Andrew K., Vinuela, Angel, Sanyaolu, Arinola, Schumacher-Schuh, Artur F., Kishore, Asha, Ahmad-Annuar, Azlina, Al Mubarak, Bashayer, Tang, Beisha, Pizarro Galleguillos, Benjamin, Jeon, Beomseok, Siddiqi, Bernadette, Casey, Bradford, Mollenhauer, Brit, Carroll, Camille, Rieder, Carlos, Pantazis, Caroline B., Comart, Charisse, Lin, Chin-Hsien, Klein, Christine, Bale, Claire, Shepherd, Claire E, Wegel, Claire, Blauwendraat, Cornelis, Vitale, Dan, Martinez-Ramirez, Daniel, Hall, Deborah, Hernandez, Dena, KP, Divya, Nguyen, Duan, Fon, Edward A., Dadiotis, Efthymios, Riley, Ekemini, Iakovenko, Elena, Stafford, Ellie, Gatto, Emilia M, Valente, Enza Maria, Vollstedt, Eva-Juliane, Faghri, Faraz, Genc, Gencer, Xiromerisiou, Georgia, Hadjigorgiou, Georgios, Hiu-Fai Chan, Germaine, Arboleda, Gonzalo, Kaishibayeva, Gulnaz, Höglinger, Günter, Leonard, Hampton, Madoev, Harutyun, Iwaki, Hirotaka, Chen, Honglei, Wu, Hsiu-Chuan, Shang, Huifang, Morris, Huw R, F. Mata, Ignacio, Keller Sarmiento, Ignacio Juan, Dagklis, Ioannis, Tarnanas, Ioannis, Aasly, Jan O., Hoenicka, Janet, Corvol, Jean-Christophe, Foo, Jia Nee, Guo, Jifeng, Junker, Johanna, Carr, Jonathan, Kim, Jonggeol Jeff, Orozco, Jorge, Jankovic, Joseph, Shulman, Joshua, Hunter, Julie, Solle, Justin C., Murphy, Kaileigh, Nuytemans, Karen, Kieburtz, Karl, Lohmann, Katja, Marek, Kenneth, Mok, Kin Ying, Kumar, Kishore, Levine, Kristin, Chahine, Lana M., Lange, Lara M., Pihlstrøm, Lasse, Screven, Laurel, Stefanis, Leonidas, Shulman, Lisa, Marsili, Luca, Parnetti, Lucilla, Kuhl, Maggie, Funayama, Manabu, Sharma, Manu, Tan, Manuela, Kauffman, Marcelo, Miranda, Marcelo, Bustamante, Maria Leonor, Stamelou, Maria, Periñan Tocino, Maria Teresa, Cornejo-Olivas, Mario, Jimenez del Rio, Marlene, Makarious, Mary B, Koretsky, Mathew, Rodriguez-Violante, Mayela, Ellis, Melina, Avenali, Micol, Rentería, Miguel E., Inca-Martines, Miguel z, Nalls, Mike A., Ibrahim Norlinah, Mohamed, Umair, Muhammad, Ip, Nancy, Louie, Naomi, Cheung, Nelson Yuk-Fai, Mencacci, Niccolò Emanuele, Wood, Nicholas, Williams, Nigel, Hattori, Nobutaka, Abdul Murad, Nor Azian, Ibrahim, Norlinah Mohamed, Monchi, Oury, Öztop Çakmak, Özgür, Öztop Çakmak, Patricio Öztop Çakmak, Lewis, Patrick Alfryn, Pastor, Pau, Reyes-Pérez, Paula, Saffie Awad, Paula, Chana, Pedro, Chan, Phillip, Kung, Pin-Jui, Chan, Piu, Pal, Pramod, Lingappa Kukkle, Prashanth, Ojha, Rajeev, Kaiyrzhanov, Rauan, Krüger, Rejko, Amouri, Rim, Weil, Rimona, Rajan, Roopa, Alcalay, Roy, Wu, Ruey-Meei, Borgohain, Rupam, Sassi, Samia Ben, Khachatryan, Samson, Bandres-Ciga, Sara, El-Sadig, Sarah, Wu, Serena, Groppa, Sergio, Azmin, Shahrul, Lim, Shen-Yang, Ur-Rehman, Shoaib, Ertan, Sibel, Stott, Simon, Jasaitye, Simona, Chowdhury, Sohini, Dumanis, Sonya, Bardien, Soraya, Lubbe, Steven, Koks, Sulev, Dey, Sumit, Foroud, Tatiana, Fon, Ted, Beach, Thomas, Gasser, Thomas, Anderson, Tim, Nguyen, Toan, Schirinzi, Tommaso, Shiraishi, Tomotaka, Pitcher, Toni, Tumas, Vitor, Mohamed, Wael, Kamel, Walaa A., Luo, Wei, Zhou, Xiaopu, Zewde, Yared Z., Song, Yeajin, Wen, Yi, Wu, Yihru, Joong Kim, Yun, Tavadyan, Zaruhi, Fang, Zih-Hua, Ojo, Oluwadamilola Omolara, Crea, Peter Wild, Abiodun, Oladunni Victoria, Levine, Kristin S, Abubakar, Sani Atta, Achoru, Charles Obiora, Adeniji, Olaleye Akinmola, Agabi, Osigwe Paul, Koretsky, Mathew J, Hall, Deborah A, Akinyemi, Rufus Olusola, Ali, Mohammed Wulgo, Shamim, Ejaz A, Padmanaban, Mahesh, Arigbodi, Ohwotemu Michael, Standaert, David G, Bello, Abiodun Hamzat, Dean, Marissa N, Erameh, Cyril Oshomah, Farombi, Temitope Hannah, Fawale, Michael Bimbola, Billingsley, Kimberley J, Imarhiagbe, Frank Aiwansoba, Jerez, Pilar Alvarez, Iwuozo, Emmanuel Uzodinma, Baker, Breeana, Komolafe, Morenikeji Adeyoyin, Malik, Laksh, Nwani, Paul Osemeke, Daida, Kensuke, Nwazor, Ernest Okwundu, Miano-Burkhardt, Abigail, Nyandaiti, Yakub Wilberforce, Obiabo, Yahaya Olugbo, Kluss, Jillian H, Odeniyi, Olanike Adedoyin, Hernandez, Dena G, Odiase, Francis Ehidiamen, Tayebi, Nahid, Ojini, Francis Ibe, Sidranksy, Ellen, Onwuegbuzie, Gerald Awele, D'Souza, Andrea M, Osaigbovo, Godwin Osawaru, Berhe, Bahafta, Reed, Xylena, Oshinaike, Olajumoke Olufemi, Leonard, Hampton L, Otubogun, Folajimi Morenikeji, Alvarado, Chelsea X, Oyakhire, Shyngle Imiewan, Ozomma, Simon Izuchukwu, Samuel, Sarah Chabiri, Taiwo, Funmilola Tolulope, Wahab, Kolawole Wasiu, Zubair, Yusuf Agboola, Kim, Jonggeol Jeffrey, Nalls, Mike A, Heilbron, Karl, Norcliffe-Kaufmann, Lucy, and Okubadejo, Njideka Ulunma
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- 2023
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8. Patient-level and system-level determinants of stroke fatality across 16 large hospitals in Ghana and Nigeria: a prospective cohort study
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Sarfo, Fred S, Akpa, Onoja M, Ovbiagele, Bruce, Akpalu, Albert, Wahab, Kolawole, Obiako, Reginald, Komolafe, Morenikeji, Owolabi, Lukman, Ogbole, Godwin, Fakunle, Adekunle, Okekunle, Akinkunmi Paul, Asowata, Osahon J, Calys-Tagoe, Benedict, Uvere, Ezinne O, Sanni, Taofeek, Olowookere, Samuel, Ibinaiye, Philip, Akinyemi, Joshua O, Arulogun, Oyedunni, Jenkins, Carolyn, Lackland, Daniel T, Tiwari, Hemant K, Isah, Suleiman Y, Abubakar, Sani A, Oladimeji, Adebayo, Adebayo, Philip, Akpalu, Josephine, Onyeonoro, Ugochukwu, Ogunmodede, James A, Akisanya, Cynthia, Mensah, Yaw, Oyinloye, Olalekan I, Appiah, Lambert, Agunloye, Atinuke M, Osaigbovo, Godwin O, Adeoye, Abiodun M, Adeleye, Osimhiarherhuo Ohifemen, Laryea, Ruth Y, Olunuga, Taiwo, Ogah, Okechukwu S, Oguike, Wisdom, Ogunronbi, Mayowa, Adeniyi, Wasiu, Olugbo, Obiabo Y, Bello, Abiodun H, Ogunjimi, Luqman, Diala, Samuel, Dambatta, Hamisu A, Singh, Arti, Adamu, Sheila, Obese, Vida, Adusei, Nathaniel, Owusu, Dorcas, Ampofo, Michael, Tagge, Raelle, Fawale, Bimbo, Yaria, Joseph, Akinyemi, Rufus O, and Owolabi, Mayowa O
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- 2023
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9. Are there differences in perceptions, preferences and attitudes towards disclosure of genetic testing for Stroke? A qualitative study among stroke-free SIREN-SIBS genomics study participants
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Arulogun, Oyedunni, Nichols, Michelle, Jenkins, Carolyn, Fakunle, Adekunle Gregory, Akpa, Onoja, Sarfo, Fred S., Akpalu, Albert, Wahab, Kolawole, Obiako, Reginald, Komolafe, Morenikeji, Owolabi, Lukman, Osaigbovo, Godwin O., Okekunle, Akinkunmi Paul, Akinyemi, Joshua, Ogbole, Godwin, Calys-Tagoe, Benedict, Adeleye, Adeniji, Mensah, Yaw, Asowata, Osahon Jeffery, Adeoye, Abiodun M., Appiah, Lambert, Singh, Arti, Adebayo, Philip, Arnett, Donna, Tiwari, Hemant K., Lackland, Daniel, Ibinaiye, Philip, Oguike, Wisdom, Melikam, Chimdinma, Sunday, Adeniyi, Bello, Abiodun, Ogah, Okechukwu, Akinyemi, Rufus, Ovbiagele, Bruce, and Owolabi, Mayowa
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- 2023
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10. Differential associations between pre-diabetes, diabetes and stroke occurrence among West Africans
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Sarfo, Fred Stephen, Ovbiagele, Bruce, Akinyemi, Joshua, Akpa, Onoja, Akpalu, Albert, Wahab, Kolawole, Ogbole, Godwin, Obiako, Reginald, Komolafe, Morenikeji, Owolabi, Lukman, Osaigbovo, Godwin, Jenkins, Carolyn, Fakunle, Adekunle, Adeoye, Abiodun, Lackland, Dan, Arnett, Donna, Tiwari, Hemant K., Olunuga, Taiwo, Uvere, Ezinne, Fawale, Bimbo, Ogah, Okechukwu, Agunloye, Atinuke, Faniyan, Moyinoluwalogo, Diala, Samuel, Yinka, Oladele, Laryea, Ruth, Osimhiarherhuo, Adeleye, Akinsanya, Cynthia, Abdulwasiu, Adeniyi, Akpalu, Josephine, Arulogun, Oyedunni, Appiah, Lambert, Dambatta, Hamisu, Olayemi, Balogun, Onasanya, Akinola, Isah, Sulaiman, Akinyemi, Rufus, and Owolabi, Mayowa
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- 2022
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11. Determinants of metabolic syndrome and its prognostic implications among stroke patients in Africa: Findings from the Stroke Investigative Research and Educational Network (SIREN) study
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Adeoye, Abiodun M., Akintunde, Adeseye A., Akinyemi, Joshua, Fakunle, Adekunle G., Sarfo, Fred S., Akpalu, Albert, Wahab, Kolawole, Obiako, Reginald, Komolafe, Morenikeji, Owolabi, Lukman, Osaigbovo, Godwin O., Akpa, Onoja, Arulogun, Oyedunni, Okekunle, Akinkunmi P., Ogah, Okechukwu S., Jenkins, Carolyn, Ogbole, Godwin, Tiwari, Hemant K., Asowata, Osahon J., Ibinaiye, Philip, Appiah, Lambert, Agunloye, Atinuke M., Yaria, Joseph, Calys-Tagoe, Benedict, Agbogu-Ike, Obiageli U., Adeniyi, Sunday, Adebayo, Philip, Balogun, Olayemi, Aderonmu, Olajumoke, Adeegbe, Oluwayemisi T., Adebayo, Oladimeji, Akinyemi, Rufus, Ovbiagele, Bruce, and Owolabi, Mayowa
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- 2022
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12. Frequency & factors associated with recurrent stroke in Ghana and Nigeria
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Akpalu, Albert, Sarfo, Fred S., Akinyemi, Joshua, Wahab, Kolawole, Komolafe, Morenikeji, Obiako, Reginald, Owolabi, Lukman, Osaigbovo, Godwin O., Ogbole, Godwin, Adebayo, Philip, Onoja, Akpa, Fakunle, Adekunle, Balogun, Olayemi, Fawale, Bimbo, Ogah, Okechukwu, Akinyemi, Rufus, Owolabi, Mayowa, and Ovbiagele, Bruce
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- 2022
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13. Feasibility, acceptability, and appropriateness of a mobile health stroke intervention among Ghanaian health workers
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Amuasi, JohnH., Agbogbatey, Melvin K., Sarfo, Fred S., Beyuo, Alexis, Duah, Kwaku, Agasiya, Patrick, Arthur, Agnes, Appiah, Lambert, Nguah, Samuel B., Bockarie, Ansumana, Ayisi-Boateng, Nana K., Boateng, Kwadwo Gyebi Agyenim, Adusei-Mensah, Nathaniel, Akpalu, Albert, and Ovbiagele, Bruce
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- 2022
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14. Nationwide rates of outpatient clinic attendance by stroke survivors in Ghana: Analysis by region and facility
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Sarfo, Fred Stephen, Commeh, Mary Efua, Tandoh, Isaac Obeng, Agbogbatey, Melvin, Ankrah, Odame, Akpalu, Albert, and Ovbiagele, Bruce
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- 2022
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15. Attitudes and perceptions towards epilepsy in an onchocerciasis-endemic region of Tanzania: a mixed approach to determine the magnitude and driving factors.
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Mushi, Vivian P., Kidima, Winifrida, Massawe, Isolide S., Magili, Pendo F., Bhwana, Dan, Kaaya, Rahel Elishilia, Kimambo, Henrika, Hyera, Herieth F., Matuja, William, Sen, Arjune, Sander, Josemir W., Colebunders, Robert, Mahone, Sloan, Newton, Charles R., Mmbando, Bruno P., EPInA Study Group, Akpalu, Albert, Godi, Anthony, Mmbando, Bruno, and Sottie, Cynthia
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ATTITUDES toward illness ,NEUROLOGICAL disorders ,PLACE-based education ,PEOPLE with epilepsy ,SOCIAL isolation - Abstract
Background: Epilepsy remains a significant public health concern in Tanzania, with affected individuals enduring stigma, whether through actions or perceptions. Myths, misunderstandings, and misconceptions about epilepsy have persisted due to a multitude of factors. Here, we assessed attitudes and perceptions toward epilepsy in Mahenge. Methods: A cross-sectional study utilising a mixed-methods approach was undertaken in eight villages in the Ulanga district of Mahenge, integrating a semi-structured questionnaire and focus group discussions (FGDs). The questionnaire involved 778 community members, and 15 FGDs were conducted (seven groups with people with epilepsy and eight without). Descriptive statistics, chi-square, and logistic regression were used for quantitative analysis, while we used NVivo version 14 for thematic analysis of qualitative data. Results: Of 778 participants, over half were women (425, 54.6%) with a median age of 41 years (IQR: 30–55) and most had completed primary education (79.9%). The majority of participants were aware of epilepsy (96.8%), yet they displayed low knowledge (51%), negative attitudes (45.5%), and perceptions (42.1%) towards the disorder. A low level of understanding was significantly associated with negative attitudes (Adjusted Odds Ratio [AOR] = 1.89, 95%CI: 1.41–2.53) and perceptions (AOR = 3.22, 95%CI: 2.05–5.04) towards epilepsy. In the qualitative analysis, often hereditary factors and infections were named as causes of epilepsy, along with misconceptions involving witchcraft and divine punishment. There was also a misconception about the contagiousness of epilepsy. Traditional healers were often the initial point of treatment. Epilepsy-related stigma was evident, with individuals with epilepsy facing derogatory labels, social isolation, and barriers to education. Lastly, there was a lack of understanding regarding a possible association between epilepsy and onchocerciasis. Conclusions: Despite high awareness of epilepsy, there is insufficient understanding, negative attitudes, and perceptions, including misconceptions and stigma about this neurologic condition. Community-based education programmes are essential for promoting proper healthcare-seeking behaviour and dispelling myths. [ABSTRACT FROM AUTHOR]
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- 2024
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16. Primary stroke prevention worldwide: translating evidence into action
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Abanto, Carlos, Abera, Semaw Ferede, Addissie, Adamu, Adebayo, Oluwadamilola, Adeleye, Amos Olufemi, Adilbekov, Yerzhan, Adilbekova, Bibigul, Adoukonou, Thierry Armel, Aguiar de Sousa, Diana, Ajagbe, Temitope, Akhmetzhanova, Zauresh, Akpalu, Albert, Álvarez Ahlgren, Jhon, Ameriso, Sebastián, Andonova, Silva, Awoniyi, Foloruso Emmanuel, Bakhiet, Moiz, Barboza, Miguel, Basri, Hamidon, Bath, Philip, Bello, Olamide, Bereczki, Dániel, Beretta, Simone, Berkowitz, Aaron, Bernabé-Ortiz, Antonio, Bernhardt, Julie, Berzina, Guna, Bisharyan, Mher, Bovet, Pascal, Budincevic, Hrvoje, Cadilhac, Dominique, Caso, Valeria, Chen, Christopher, Chin, Jerome, Chwojnicki, Kamil, Conforto, Adriana, Cruz, Vitor Tedim, D'Amelio, Marco, Danielyan, Kristine, Davis, Stephen, Demarin, Vida, Dempsey, Robert, Dichgans, Martin, Dokova, Klara, Donnan, Geoffrey, Elkind, Mitchell S., Endres, Matthias, Fischer, Urs, Gankpé, Fortuné, Gaye Saavedra, Andrés, Gil, Artyom, Giroud, Maurice, Gnedovskaya, Elena, Hachinski, Vladimir, Hafdi, Melanie, Hamadeh, Randah, Hamzat, T. Kolapo, Hankey, Graeme, Heldner, Mirjam, Ibrahim, Etedal Ahmed, Ibrahim, Norlinah Mohamed, Inoue, Manabu, Jee, Sungju, Jeng, Jiann-Shing, Kalkonde, Yogesh, Kamenova, Saltanat, Karaszewski, Bartosz, Kelly, Peter, Khan, Taskeen, Kiechl, Stefan, Kondybayeva, Aida, Kõrv, Janika, Kravchenko, Michael, Krishnamurthi, Rita V., Kruja, Jera, Lakkhanaloet, Mongkol, Langhorne, Peter, Lavados, Pablo M., Law, Zhe Kang, Lawal, Abisola, Lazo-Porras, Maria, Lebedynets, Dmytro, Lee, Tsong-Hai, Leung, Thomas, Liebeskind, David S., Lindsay, Patrice, López-Jaramillo, Patricio, Lotufo, Paulo Andrade, Machline-Carrion, Julia, Makanjuola, Akintomiwa, Markus, Hugh Stephen, Marquez-Romero, Juan Manuel, Medina, Marco, Medukhanova, Sabina, Mehndiratta, Man Mohan, Merkin, Alexandr, Mirrakhimov, Erkin, Mohl, Stephanie, Moscoso-Porras, Miguel, Müller-Stierlin, Annabel, Murphy, Sean, Musa, Kamarul Imran, Nasreldein, Ahmed, Nogueira, Raul Gomes, Nolte, Christian, Noubiap, Jean Jacques, Novarro-Escudero, Nelson, Ogun, Yomi, Oguntoye, Richard Ayobami, Oraby, Mohammed Ibrahim, Osundina, Morenike, Ovbiagele, Bruce, Orken, Dilek Necioglu, Ozdemir, Atilla Özcan, Ozturk, Serefnur, Paccot, Melanie, Phromjai, Jurairat, Piradov, Piradov, Platz, Thomas, Potpara, Tatjana, Ranta, Annemarei, Rathore, Farooq, Richard, Edo, Sacco, Ralph L., Sahathevan, Ramesh, Santos Carquín, Irving, Saposnik, Gustavo, Sarfo, Fred Stephen, Sharma, Mike, Sheth, Kevin, Shobhana, A., Suwanwela, Nijasri, Svyato, Irina, Sylaja, P.N., Tao, Xuanchen, Thakur, Kiran T., Toni, Danilo, Topcuoglu, Mehmet Akif, Torales, Julio, Towfighi, Amytis, Truelsen, Thomas Clement, Tsiskaridze, Alexander, Tulloch-Reid, Marshall, Useche, Nicolás, Vanacker, Peter, Vassilopoulou, Sophia, Vukorepa, Gorana, Vuletic, Vladimira, Wahab, Kolawole W., Wang, Wenzhi, Wijeratne, Tissa, Wolfe, Charles, Yifru, Yared Mamushet, Yock-Corrales, Adriana, Yonemoto, Naohiro, Yperzeele, Laetitia, Zhang, Puhong, Owolabi, Mayowa O, Thrift, Amanda G, Mahal, Ajay, Ishida, Marie, Martins, Sheila, Johnson, Walter D, Pandian, Jeyaraj, Abd-Allah, Foad, Yaria, Joseph, Phan, Hoang T, Roth, Greg, Gall, Seana L, Beare, Richard, Phan, Thanh G, Mikulik, Robert, Akinyemi, Rufus O, Norrving, Bo, Brainin, Michael, and Feigin, Valery L
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- 2022
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17. Nurses’ Perspectives on a Novel Stroke Nurse Training Program in Lusaka, Zambia (P1-15.001)
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Chen, Phoebe, primary, Nanduri, Samhita, additional, Sneh, Gabriel, additional, Braun, Sarah, additional, Appiah, Monica, additional, Asare, Maxwell, additional, Asukile, Melody, additional, Chomba, Mashina, additional, Gebrewold, Meron, additional, Kaunda, Kasakula, additional, Kinkata, Michael, additional, Mwanza, Jessica, additional, Mwenya, Royce, additional, Peele, Muchinka, additional, Peloso, Alexandra, additional, Singoyi, Jane, additional, Quarton, Jonathan, additional, Baral, Stefan, additional, Birbeck, Gretchen, additional, Gottesman, Rebecca, additional, Sikazwe, Izukanji, additional, Winch, Peter, additional, Akpalu, Albert, additional, Sykes, Lucy, additional, Prust, Morgan, additional, and Saylor, Deanna, additional
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- 2024
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18. A Novel Afrocentric Stroke Risk Assessment Score: Models from the Siren Study
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Akpa, Onoja, Sarfo, Fred S., Owolabi, Mayowa, Akpalu, Albert, Wahab, Kolawole, Obiako, Reginald, Komolafe, Morenikeji, Owolabi, Lukman, Osaigbovo, Godwin O., Ogbole, Godwin, Tiwari, Hemant K., Jenkins, Carolyn, Fakunle, Adekunle G., Olowookere, Samuel, Uvere, Ezinne O., Akinyemi, Joshua, Arulogun, Oyedunni, Akpalu, Josephine, Tito-Ilori, Moyinoluwalogo M., Asowata, Osahon J., Ibinaiye, Philip, Akisanya, Cynthia, Oyinloye, Olalekan I., Appiah, Lambert, Sunmonu, Taofik, Olowoyo, Paul, Agunloye, Atinuke M., Adeoye, Abiodun M., Yaria, Joseph, Lackland, Daniel T., Arnett, Donna, Laryea, Ruth Y., Adigun, Taiwo O., Okekunle, Akinkunmi P., Calys-Tagoe, Benedict, Ogah, Okechukwu S., Ogunronbi, Mayowa, Obiabo, Olugbo Y., Isah, Suleiman Y., Dambatta, Hamisu A., Tagge, Raelle, Ogenyi, Obande, Fawale, Bimbo, Melikam, Chimdinma L., Onasanya, Akinola, Adeniyi, Sunday, Akinyemi, Rufus, and Ovbiagele, Bruce
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- 2021
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19. Influence of age on links between major modifiable risk factors and stroke occurrence in West Africa
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Sarfo, Fred S., Akpa, Onoja, Ovbiagele, Bruce, Akpalu, Albert, Wahab, Kolawole, Komolafe, Morenikeji, Obiako, Reginald, Owolabi, Lukman, Osaigbovo, Godwin O., Jenkins, Carolyn, Ogbole, Godwin, Fakunle, Adekunle, Tiwari, Hemant K., Arulogun, Oyedunni, Arnett, Donna K., Asowata, Osahon, Ogah, Okechukwu, Akinyemi, Rufus O., and Owolabi, Mayowa O.
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- 2021
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20. Neurological disorders encountered at an out-patient clinic in Ghana's largest medical center: A 16-year review
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Akpalu, Albert, Adjei, Patrick, Nkromah, Kodwo, Poku, Foster Osei, and Sarfo, Fred Stephen
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- 2021
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21. Frequency and factors associated with post-stroke seizures in a large multicenter study in West Africa
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Sarfo, Fred S., Akinyemi, Joshua, Akpalu, Albert, Wahab, Kolawole, Yaria, Joseph, Adebayo, Oladimeji, Komolafe, Morenike, Obiako, Reginald, Owolabi, Lukman, Osaigbovo, Godwin O., Jenkins, Carolyn, Mensah, Yaw, Ogbole, Godwin, Calys-Tagoe, Benedict, Adebayo, Philip, Appiah, Lambert, Singh, Arti, Fakunle, Adekunle, Uvere, Ezinne, Hemant, Tiwari, Balogun, Olayemi, Adeleye, Osi, Fawale, Bimbo, Abdulwasiu, Adeniyi, Ogunjimi, Luqman, Akinola, Onasanya, Arulogun, Oyedunni, Donna, Arnette, Ogah, Okechukwu, Akinyemi, Rufus, Ovbiagele, Bruce, and Owolabi, Mayowa O.
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- 2021
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22. Phone-Based Intervention under Nurse Guidance after Stroke (PINGS II) Study: Protocol for a Phase III Randomized Clinical Trial
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Sarfo, Fred Stephen, Akpalu, Albert, Bockarie, Ansumana, Appiah, Lambert, Nguah, Samuel Blay, Ayisi-Boateng, Nana Kwame, Adamu, Sheila, Neizer, Christiana, Arthur, Agnes, Nyamekye, Richard, Agyenim-Boateng, Kwabena, Tagge, Raelle, Adusei-Mensah, Nathaniel, Ampofo, Michael, Laryea, Ruth, Singh, Arti, Amuasi, John Humphry, and Ovbiagele, Bruce
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- 2021
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23. Antecedent febrile illness and occurrence of stroke in West Africa: The SIREN study
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Sarfo, Fred Stephen, Ovbiagele, Bruce, Matthew, Onoja Akpa, Akpalu, Albert, Wahab, Kolawole, Obiako, Reginald, Owolabi, Lukman, Asowata, Osahon, Ogbole, Godwin, Komolafe, Morenikeji, Akinyemi, Rufus, and Owolabi, Mayowa
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- 2020
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24. Clinical and neuroimaging factors associated with 30-day fatality among indigenous West Africans with spontaneous intracerebral hemorrhage
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Komolafe, Morenikeji A., primary, Sunmonu, Taofiki, additional, Akinyemi, Joshua, additional, Sarfo, Fred S., additional, Akpalu, Albert, additional, Wahab, Kolawole, additional, Obiako, Reginald, additional, Owolabi, Lukman, additional, Osaigbovo, Godwin O., additional, Ogbole, Godwin, additional, Tiwari, Hemant K., additional, Jenkins, Carolyn, additional, Lackland, Daniel T., additional, Fakunle, Adekunle G., additional, Uvere, Ezinne, additional, Akpa, Onoja, additional, Dambatta, Hamisu A., additional, Akpalu, Josephine, additional, Onasanya, Akinola, additional, Olaleye, Adeniji, additional, Ogah, Okechukwu S., additional, Isah, Sulaiman Y., additional, Fawale, Micheal B., additional, Adebowale, Akintunde, additional, Okekunle, Akinkunmi P., additional, Arnett, Donna, additional, Adeoye, Abiodun M., additional, Agunloye, Atinuke M., additional, Bello, Abiodun H., additional, Aderibigbe, Adeniyi S., additional, Idowu, Ahmed O., additional, Sanusi, Ahmad A., additional, Ogunmodede, Adebimpe, additional, Balogun, Simon A., additional, Egberongbe, Adedeji A., additional, Rotimi, Folorunso T., additional, Fredrick, Adeyemi, additional, Akinnuoye, Andrew O., additional, Adeniyi, Folu A., additional, Calys-Tagoe, Benedict, additional, Adebayo, Philip, additional, Arulogun, Oyedunni, additional, Agbogu-Ike, Obiageli U., additional, Yaria, Joseph, additional, Appiah, Lambert, additional, Ibinaiye, Philip, additional, Singh, Arti, additional, Adeniyi, Sunday, additional, Olalusi, Oladotun, additional, Mande, Aliyu, additional, Balogun, Olayemi, additional, Akinyemi, Rufus, additional, Ovbiagele, Bruce, additional, and Owolabi, Mayowa, additional
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- 2023
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25. Risk Factor Characterization of Ischemic Stroke Subtypes Among West Africans
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Sarfo, Fred S., Ovbiagele, Bruce, Akpa, Onoja, Akpalu, Albert, Wahab, Kolawole, Obiako, Reginald, Komolafe, Morenikeji, Owolabi, Lukman, Ogbole, Godwin, Calys-Tagoe, Benedict, Fakunle, Adekunle, Sanni, Taofeek, Mulugeta, Gebregziabher, Abdul, Salaam, Akintunde, Adeseye A., Olowookere, Samuel, Uvere, Ezinne O., Ibinaiye, Philip, Akinyemi, Joshua, Uwanuruochi, Kelechukwu, Olayemi, Balogun, Odunlami, Olufemi A., Abunimye, Esther, Arulogun, Oyedunni, Isah, Suleiman Y., Abubakar, Sani A., Oladimeji, Adebayo, Adebayo, Philip, Shidali, Vincent, Chukwuonye, Innocent I., Akpalu, Josephine, Tito-Ilori, Moyinoluwalogo M., Asowata, Osahon J., Sanya, Emmanuel O., Amusa, Ganiyu, Onyeonoro, Ugochukwu, Ogunmodede, James A., Sule, Abdullateef G., Akisanya, Cynthia, Mensah, Yaw, Oyinloye, Olalekan I., Appiah, Lambert, Agunloye, Atinuke M., Osaigbovo, Godwin O., Olabinri, Eunice, Kolo, Philip M., Okeke, Obiora, Adeoye, Abiodun M., Ajose, Olabamiji, Jenkins, Carolyn, Lackland, Daniel T., Egberongbe, Adedeji A., Adeniji, Olaleye, Ohifemen Adeleye, Osimhiarherhuo, Tiwari, Hemant K., Arnett, Donna, Laryea, Ruth Y., Olunuga, Taiwo, Akinwande, Kazeem S., Imoh, Lucius, Ogah, Okechukwu S., Melikam, Ezinne S., Adebolaji, Adeyemo, Oguike, Wisdom, Ogunronbi, Olumayowa, Adeniyi, Wasiu, Olugbo, Obiabo Y., Bello, Abiodun H., Ohagwu, Kenneth A., Ogunjimi, Luqman, Agyekum, Francis, Iheonye, Henry, Adesina, Julius, Diala, Samuel, Dambatta, Hamisu A., Ikubor, Joyce, Singh, Arti, Adamu, Sheila, Obese, Vida, Adusei, Nathaniel, Owusu, Dorcas, Ampofo, Michael, Tagge, Raelle, Efidi, Richard, Fawale, Bimbo, Yaria, Joseph, Akinyemi, Rufus, and Owolabi, Mayowa
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- 2021
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26. Non-cigarette Tobacco Use and Stroke Among West Africans: Evidence From the SIREN Study.
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Fakunle, Adekunle Gregory, Okekunle, Akinkunmi Paul, Asowata, Osahon Jeffery, Akpa, Onoja, Sarfo, Fred S, Akpalu, Albert, Wahab, Kolawole, Obiako, Reginald, Komolafe, Morenikeji, Owolabi, Lukman, Osaigbovo, Godwin O, Adeoye, Abiodun M, Tiwari, Hemant K, Uvere, Ezinne O, Akinyemi, Joshua, Jenkins, Carolyn, Arulogun, Oyedunni, Ibinaiye, Philip, Appiah, Lambert T, and Bello, Temilade
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TOBACCO use ,MAGNETIC resonance imaging ,COMPUTED tomography ,SYMPTOMS ,STROKE - Abstract
Introduction Non-cigarette tobacco (NCT) represents a form of tobacco use with a misperceived significance in chronic disease events. Whether NCT use is sufficient to promote stroke events, especially among Africans, is yet to be understood. This study assessed the relationship between NCT use and stroke among indigenous Africans. Methods A total of 7617 respondents (NCT users: 41 vs. non-NCT: 7576) from the Stroke Investigative Research and Educational Network (SIREN) study were included in the current analysis. NCT use was defined as self-reported use of smoked (cigars or piper) or smokeless (snuff or chewed) tobacco in the past year preceding stroke events. Stroke was defined based on clinical presentation and confirmed with a cranial computed tomography/magnetic resonance imaging. Multivariable-adjusted logistic regression was applied to estimate the odds ratio (OR) and 95% confidence interval (CI) for the relationship of NCT with stroke at a two-sided p <.05. Results Out of the 41 (0.54%) who reported NCT use, 27 (65.9%) reported using smokeless NCT. NCT users were older than non-NCT users (62.8 ± 15.7 vs. 57.7 ± 14.8 years). Overall, NCT use was associated with first-ever stroke (OR: 2.08; 95% CI: 1.02, 4.23) in the entire sample. Notably, smokeless NCT use was independently associated with higher odds of stroke (OR: 2.74; 95% CI: 1.15, 6.54), but smoked NCT use (OR: 0.16; 95% CI: 0.02, 1.63) presented a statistically insignificant association after adjusting for hypertension and other covariates. Conclusions NCT use was associated with higher odds of stroke, and public health interventions targeting NCT use might be promising in reducing the burden of stroke among indigenous Africans. Implications A detailed understanding of the relationship between NCT use and stroke will likely inform well-articulated policy guidance and evidence-based recommendations for public health prevention and management of stroke on the African continent. [ABSTRACT FROM AUTHOR]
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- 2024
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27. Non-cigarette Tobacco Use and Stroke Among West Africans: Evidence From the SIREN Study
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Fakunle, Adekunle Gregory, primary, Okekunle, Akinkunmi Paul, additional, Asowata, Osahon Jeffery, additional, Akpa, Onoja, additional, Sarfo, Fred S, additional, Akpalu, Albert, additional, Wahab, Kolawole, additional, Obiako, Reginald, additional, Komolafe, Morenikeji, additional, Owolabi, Lukman, additional, Osaigbovo, Godwin O, additional, Adeoye, Abiodun M, additional, Tiwari, Hemant K, additional, Uvere, Ezinne O, additional, Akinyemi, Joshua, additional, Jenkins, Carolyn, additional, Arulogun, Oyedunni, additional, Ibinaiye, Philip, additional, Appiah, Lambert T, additional, Bello, Temilade, additional, Singh, Arti, additional, Yaria, Joseph, additional, Calys-Tagoe, Benedict, additional, Ogbole, Godwin, additional, Chukwuonye, Ijezie, additional, Melikam, Chidinma, additional, Adebayo, Philip, additional, Mensah, Yaw, additional, Adebayo, Oladimeji, additional, Adeniyi, Sunday, additional, Oguike, Wisdom, additional, Donna, Arnett, additional, Akinyemi, Rufus, additional, Ovbiagele, Bruce, additional, and Owolabi, Mayowa, additional
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- 2023
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28. Risk Assessment Score and χ 2 Automatic Interaction Detection Algorithm for Hypertension Among Africans: Models From the SIREN Study
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Asowata, Osahon, primary, Okekunle, Akinkunmi, additional, Akpa, Onoja, additional, Fakunle, Adekunle, additional, Akinyemi, Joshua, additional, Komolafe, Morenikeji, additional, Sarfo, Fred, additional, Akpalu, Albert, additional, Obiako, Reginald, additional, Wahab, Kolawole, additional, Osaigbovo, Godwin, additional, Owolabi, Lukman, additional, Jenkins, Carolyn, additional, Calys-Tagoe, Benedict, additional, Arulogun, Oyedunni, additional, Ogbole, Godwin, additional, Ogah, Okechukwu S., additional, Appiah, Lambert, additional, Ibinaiye, Philip, additional, Adebayo, Philip, additional, Singh, Arti, additional, Adeniyi, Sunday, additional, Mensah, Yaw, additional, Laryea, Ruth, additional, Balogun, Olayemi, additional, Chukwuonye, Ijezie, additional, Akinyemi, Rufus, additional, Ovbiagele, Bruce, additional, and Owolabi, Mayowa, additional
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- 2023
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29. Research participants’ perception of ethical issues in stroke genomics and neurobiobanking research in Africa
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Jegede, Ayodele, primary, Balogun, Olubukola, additional, Olorunsogbon, Olorunyomi Felix, additional, Nichols, Michelle, additional, Akinyemi, Joshua, additional, Jenkins, Carolyn, additional, Ogunronbi, Mayowa, additional, Singh, Arti, additional, Obiako, Reginald, additional, Wahab, Kolawole, additional, Bello, Abiodun, additional, Akpalu, Albert, additional, Sarfo, Fred S., additional, Owolabi, Lukman F., additional, Ojebuyi, Babatunde, additional, Adigun, Muyiwa, additional, Olujobi, Dorcas, additional, Musbahu, Rabiu, additional, Titiloye, Musibau, additional, Afolami, Ibukun, additional, Calys-Tagoe, Benedict, additional, Uvere, Ezinne, additional, Laryea, Ruth, additional, Fakunle, Adekunle, additional, Adeleye, Osi, additional, Adesina, Deborah, additional, Mensah, Nathaniel, additional, Oguike, Wisdom, additional, Coleman, Nathaniel, additional, Adeniyi, Sunday, additional, Omotoso, Lanre, additional, Asibey, Shadrack, additional, Melikam, Lois, additional, Yusuf, Jibril, additional, Gbenga, Abdullateef, additional, Mande, Aliyu, additional, Uthman, Muhammed, additional, Kalaria, Rajesh N., additional, Owolabi, Mayowa, additional, Ovbiagele, Bruce, additional, Arulogun, Oyedunni, additional, and Akinyemi, Rufus O., additional
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- 2023
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30. Intracranial aneurysms in Ghanaian adults
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D. Sarkodie, Benjamin, primary, B. Jimah, Bashiru, additional, H. Mohammed, Abdullah, additional, Akpalu, Albert, additional, K. Brakohiapa, Edmund, additional, Anim, Dorothea, additional, and O. Botwe, Benard, additional
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- 2023
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31. Abstract P155: Low Vegetable Consumption Doubles The Risk Of Stroke Among Hypertensives In West Africa
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Asowata, Osahon J, primary, Bodunde, Ifeoluwa, additional, Danladi, David K, additional, Akpa, Onoja M, additional, Fakunle, Adekunle, additional, SARFO, FRED S, additional, Akpalu, Albert, additional, Obiako, Reginald, additional, Wahab, Kolawole W, additional, Osaigbovo, Godwin, additional, Ogbole, Godwin, additional, Akinyemi, Joshua, additional, Owolabi, Lukman, additional, Komolafe, Morenikeji, additional, Akinyemi, Rufus O, additional, Ovbiagele, Bruce, additional, Okekunle, Akinkunmi P, additional, and Owolabi, Mayowa, additional
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- 2023
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32. Dominant modifiable risk factors for stroke in Ghana and Nigeria (SIREN): a case-control study
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Owolabi, Mayowa Ojo, Sarfo, Fred Stephen, Akinyemi, Rufus, Gebregziabher, Mulugeta, Akpa, Onoja, Akpalu, Albert, Wahab, Kolawole, Obiako, Reginald, Owolabi, Lukman, Ovbiagele, Bruce, Tiwari, Hemant K, Arnett, Donna, Lackland, Daniel, Adeoye, Abiodun Moshood, Akin, Ojagbemi, Ogbole, Godwin, Jenkins, Carolyn, Arulogun, Oyedunni, Ryan, Irvin Marguerite, Armstrong, Kevin, Olowoyo, Paul, Komolafe, Morenikeji, Osaigbovo, Godwin, Obiabo, Olugbo, Chukwuonye, Innocent, Adebayo, Philip, Adebayo, Oladimeji, Omololu, Ayanfe, Otubogun, Folajimi, Olaleye, Adeniji, Durodola, Amina, Olunuga, Taiwo, Akinwande, Kazeem, Aridegbe, Mayowa, Fawale, Bimbo, Adeleye, Omisore, Kolo, Philip, Appiah, Lambert, Singh, Arti, Adamu, Sheila, Awuah, Dominic, Saulson, Raelle, Agyekum, Francis, Shidali, Vincent, Ogah, Okechukwu, Oguntade, Ayodipopo, Umanruochi, Kelechi, Iheonye, Henry, Imoh, Lucius, Afolaranmi, Tolulope, Calys-Tagoe, Benedict, Okeke, Obiora, Fakunle, Adekunle, Akinyemi, Joshua, Akpalu, Josephine, Ibinaiye, Philip, Agunloye, Atinuke, Sanni, Taofeeq, Bisi, Ayotunde, Efidi, Chika, Bock-Oruma, Andrew, Melikam, Sylvia, Olaniyan, Lanre, Yaria, Joseph, Odo, Chidi Joseph, Lakoh, Sulaiman, Ogunjimi, Luqman, Salaam, Abdul, Oyinloye, Lekan, Asaleye, Caroline, Sanya, Emmanuel, Olowookere, Samuel, Makanjuola, Akintomiwa, Oguntoye, Ayobami, Uvere, Ezinne, Faniyan, Moyinoluwalogo, Akintunde, Adeseye, Kehinde, Issa, Diala, Samuel, Adeleye, Osimhiarherhuo, Ajose, Olabanji A., Onyeonoro, Ugochukwu, Amusa, Adeniyi G., Owusu, Dorcas, Mensah, Yaw, Owolabi, Mayowa O, and Sarfo, Fred
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- 2018
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33. Editorial: Epilepsy research in the developing countries: the neuro-ethical issues, cross-cultural di.
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Mukasa, Mark Kaddu, Akpalu, Albert, Ejilemele, Adetoun, and Ogunrin, Olubunmi Akindele
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EPILEPSY ,DEVELOPING countries ,CHILDHOOD epilepsy - Abstract
This article published in Frontiers in Neurology discusses the neuro-ethical issues and cross-cultural differences in epilepsy research in developing countries. The authors emphasize the importance of understanding the impact of epilepsy research on individuals' holistic health, including cognitive and social aspects. The article includes studies from diverse cultures and settings, covering topics such as perceived causes and management of epilepsy, the effects of epilepsy education on pregnancy outcomes, genetic causes of epilepsy, social and psychological consequences of epilepsy, epilepsy management, and ethical considerations in epilepsy research. The authors stress the need for culturally relevant and responsive ethical frameworks to promote valid research in low- and medium-income countries. The article also mentions other studies, including one that explores the treatment gap in developing countries and another that examines the effectiveness of anticonvulsant therapy in Nigerian Africans. Additionally, the use of functional mapping in the evaluation of epilepsy surgery is discussed. [Extracted from the article]
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- 2024
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34. Identification of genetic risk loci and causal insights associated with Parkinson's disease in African and African admixed populations: a genome-wide association study
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Rizig, Mie, primary, Bandres-Ciga, Sara, additional, Makarious, Mary B, additional, Ojo, Oluwadamilola Omolara, additional, Crea, Peter Wild, additional, Abiodun, Oladunni Victoria, additional, Levine, Kristin S, additional, Abubakar, Sani Atta, additional, Achoru, Charles Obiora, additional, Vitale, Dan, additional, Adeniji, Olaleye Akinmola, additional, Agabi, Osigwe Paul, additional, Koretsky, Mathew J, additional, Agulanna, Uchechi, additional, Hall, Deborah A, additional, Akinyemi, Rufus Olusola, additional, Xie, Tao, additional, Ali, Mohammed Wulgo, additional, Shamim, Ejaz A, additional, Ani-Osheku, Ifeyinwa, additional, Padmanaban, Mahesh, additional, Arigbodi, Ohwotemu Michael, additional, Standaert, David G, additional, Bello, Abiodun Hamzat, additional, Dean, Marissa N, additional, Erameh, Cyril Oshomah, additional, Elsayed, Inas, additional, Farombi, Temitope Hannah, additional, Okunoye, Olaitan, additional, Fawale, Michael Bimbola, additional, Billingsley, Kimberley J, additional, Imarhiagbe, Frank Aiwansoba, additional, Jerez, Pilar Alvarez, additional, Iwuozo, Emmanuel Uzodinma, additional, Baker, Breeana, additional, Komolafe, Morenikeji Adeyoyin, additional, Malik, Laksh, additional, Nwani, Paul Osemeke, additional, Daida, Kensuke, additional, Nwazor, Ernest Okwundu, additional, Miano-Burkhardt, Abigail, additional, Nyandaiti, Yakub Wilberforce, additional, Fang, Zih-Hua, additional, Obiabo, Yahaya Olugbo, additional, Kluss, Jillian H, additional, Odeniyi, Olanike Adedoyin, additional, Hernandez, Dena G, additional, Odiase, Francis Ehidiamen, additional, Tayebi, Nahid, additional, Ojini, Francis Ibe, additional, Sidranksy, Ellen, additional, Onwuegbuzie, Gerald Awele, additional, D'Souza, Andrea M, additional, Osaigbovo, Godwin Osawaru, additional, Berhe, Bahafta, additional, Osemwegie, Nosakhare, additional, Reed, Xylena, additional, Oshinaike, Olajumoke Olufemi, additional, Leonard, Hampton L, additional, Otubogun, Folajimi Morenikeji, additional, Alvarado, Chelsea X, additional, Oyakhire, Shyngle Imiewan, additional, Ozomma, Simon Izuchukwu, additional, Samuel, Sarah Chabiri, additional, Taiwo, Funmilola Tolulope, additional, Wahab, Kolawole Wasiu, additional, Zubair, Yusuf Agboola, additional, Iwaki, Hirotaka, additional, Kim, Jonggeol Jeffrey, additional, Morris, Huw R, additional, Hardy, John, additional, Nalls, Mike A, additional, Heilbron, Karl, additional, Norcliffe-Kaufmann, Lucy, additional, Blauwendraat, Cornelis, additional, Houlden, Henry, additional, Singleton, Andrew, additional, Okubadejo, Njideka Ulunma, additional, Okubadejo, Njideka, additional, Ojo, Oluwadamilola, additional, Abiodun, Oladunni, additional, Achoru, Charles, additional, Agabi, Osigwe, additional, Akinyemi, Rufus, additional, Ali, Mohammed, additional, Arigbodi, Ohwotemu, additional, Bello, Abiodun, additional, Erameh, Cyril, additional, Farombi, Temitope, additional, Fawale, Michael, additional, Imarhiagbe, Frank, additional, Iwuozo, Emmanuel, additional, Komolafe, Morenikeji, additional, Nwani, Paul, additional, Nwazor, Ernest, additional, Nyandaiti, Yakub, additional, Obiabo, Yahaya, additional, Odeniyi, Olanike, additional, Odiase, Francis, additional, Ojini, Francis, additional, Onwuegbuzie, Gerald, additional, Osaigbovo, Godwin, additional, Oshinaike, Olajumoke, additional, Otubogun, Folajimi, additional, Oyakhire, Shyngle, additional, Ozomma, Simon, additional, Samuel, Sarah, additional, Taiwo, Funmilola, additional, Wahab, Kolawole, additional, Zubair, Yusuf, additional, Gams Massi, Daniel, additional, Gueumekane Bila lamou, Eric, additional, Njamnshi Nfor, Leonard, additional, Magnerou, Mélanie Annick, additional, Fogang Fogoum, Yannick, additional, Shalash, Ali, additional, El-FawaI, Hassan, additional, Khedr, Eman, additional, Fawi, Gharib, additional, A. Eltantawi, Mohamed, additional, Salama, Mohamed, additional, El-Jaafary, Shaimaa, additional, Hamed, Sharifa, additional, Tafesse Mengesha, Abenet, additional, Alemayehu Ayele, Biniyam, additional, Melka Oda, Dereje, additional, Zenebe Zewde, Yared, additional, Debebe Gelan, Yohanesse, additional, AkpaIu, Albert, additional, Charway-Felli, Augustina, additional, Stephen Sarfo, Fred, additional, Adjei, Patrick, additional, Obese, Vida, additional, Bocoum, Abdoulaye, additional, Koita, Abdou, additional, Oumar Guinto, Cheick, additional, Coulibaly, Toumany, additional, Maiga, Youssoufa, additional, Kone, Zaynab, additional, Bell, Abiodun, additional, Adebowale, Akintunde A., additional, Akpekpe, John, additional, lyagba, Alagoma, additional, Wulgo, Ali Mohammed, additional, Arabambi, Babawale, additional, Agu, Christian, additional, Dike, Franklin, additional, Ishola, Ismail, additional, Abiodun, Kehinde, additional, Ekenze, Oluchi, additional, Agabi Osigwe, Paul, additional, Balarabe, Salisu, additional, Abubakar, Sani, additional, Williams, Uduak, additional, Fall, Maouly, additional, Mamadou Diop, Alassane, additional, Hilaire Dominique, Ewodo Touna, additional, Mochan, Andre, additional, Modi, Girish, additional, Dindayal, Saiesha, additional, Ali Awadelkareem, Eman, additional, Dahawi, Maha, additional, Awadelkareem, Mosab Ali, additional, Misbah, Sarah, additional, Mushengez, Brighton, additional, Kimambo, Henrika, additional, Msango, Leonard, additional, Adebayo, Philip, additional, OKeng, Kigocha, additional, Diekker, Marieke, additional, URassa, Sarah, additional, Gouider, Riadh, additional, Ben Djebara, Mouna, additional, Gargouri, Amina, additional, Kacem, Imen, additional, Nasri, Amina, additional, Mrabet, Saloua, additional, Sghaier, Ikram, additional, Mkada, Imen, additional, Atadzhanov, Masharip, additional, Chishimba, Lorraine, additional, Rizig, Mie, additional, Jama, Fatumah, additional, Nalls, Mike, additional, Shamim, Ejaz, additional, Jonas, Cabell, additional, Williamson, Jared, additional, Hall, Deborah A., additional, Rosenbaum, Marc, additional, Davis, Staci, additional, Dean, Marissa, additional, Cromer, Candace, additional, Smith, Jenna, additional, Ruffrage, Lauren, additional, Richardson, Joseph, additional, Sipma, Rebeka, additional, Padmanaban, Manesh, additional, Warren, Natalie, additional, Mercado, Tomas, additional, Disbrow, Elizabeth, additional, Chauppeta, Brian, additional, Thomas-Dean, Fermine, additional, Toms, Jamie, additional, Lofton, Katelyn, additional, Rawls, Ashley, additional, Rizer, Kyle, additional, Black, Nieci, additional, Solle, Justin, additional, O'Grady, Alyssa, additional, Sherer, Todd, additional, Fiske, Brian, additional, Başak, A. Nazlı, additional, Tan, Ai Huey, additional, Noyce, Alastair, additional, Akpalu, Albert, additional, Espay, Alberto, additional, Martínez-Carrasco, Alejandro, additional, Medina, Alex, additional, Zimprich, Alexander, additional, Brice, Alexis, additional, Karimova, Altynay, additional, Hernandez, Alvaro, additional, Illarionova, Anastasia, additional, Quattrone, Andrea, additional, Singleton, Andrew B, additional, Sobering, Andrew K., additional, Vinuela, Angel, additional, Sanyaolu, Arinola, additional, Schumacher-Schuh, Artur F., additional, Kishore, Asha, additional, Ahmad-Annuar, Azlina, additional, Al Mubarak, Bashayer, additional, Tang, Beisha, additional, Pizarro Galleguillos, Benjamin, additional, Jeon, Beomseok, additional, Siddiqi, Bernadette, additional, Casey, Bradford, additional, Mollenhauer, Brit, additional, Carroll, Camille, additional, Rieder, Carlos, additional, Pantazis, Caroline B., additional, Comart, Charisse, additional, Lin, Chin-Hsien, additional, Klein, Christine, additional, Bale, Claire, additional, Shepherd, Claire E, additional, Wegel, Claire, additional, Martinez-Ramirez, Daniel, additional, Hall, Deborah, additional, Hernandez, Dena, additional, KP, Divya, additional, Nguyen, Duan, additional, Fon, Edward A., additional, Dadiotis, Efthymios, additional, Riley, Ekemini, additional, Iakovenko, Elena, additional, Stafford, Ellie, additional, Gatto, Emilia M, additional, Valente, Enza Maria, additional, Vollstedt, Eva-Juliane, additional, Faghri, Faraz, additional, Genc, Gencer, additional, Xiromerisiou, Georgia, additional, Hadjigorgiou, Georgios, additional, Hiu-Fai Chan, Germaine, additional, Arboleda, Gonzalo, additional, Kaishibayeva, Gulnaz, additional, Höglinger, Günter, additional, Leonard, Hampton, additional, Madoev, Harutyun, additional, Chen, Honglei, additional, Wu, Hsiu-Chuan, additional, Shang, Huifang, additional, F. Mata, Ignacio, additional, Keller Sarmiento, Ignacio Juan, additional, Dagklis, Ioannis, additional, Tarnanas, Ioannis, additional, Aasly, Jan O., additional, Hoenicka, Janet, additional, Corvol, Jean-Christophe, additional, Foo, Jia Nee, additional, Guo, Jifeng, additional, Junker, Johanna, additional, Carr, Jonathan, additional, Kim, Jonggeol Jeff, additional, Orozco, Jorge, additional, Jankovic, Joseph, additional, Shulman, Joshua, additional, Hunter, Julie, additional, Solle, Justin C., additional, Murphy, Kaileigh, additional, Nuytemans, Karen, additional, Kieburtz, Karl, additional, Lohmann, Katja, additional, Marek, Kenneth, additional, Mok, Kin Ying, additional, Kumar, Kishore, additional, Levine, Kristin, additional, Chahine, Lana M., additional, Lange, Lara M., additional, Pihlstrøm, Lasse, additional, Screven, Laurel, additional, Stefanis, Leonidas, additional, Shulman, Lisa, additional, Marsili, Luca, additional, Parnetti, Lucilla, additional, Kuhl, Maggie, additional, Funayama, Manabu, additional, Sharma, Manu, additional, Tan, Manuela, additional, Kauffman, Marcelo, additional, Miranda, Marcelo, additional, Bustamante, Maria Leonor, additional, Stamelou, Maria, additional, Periñan Tocino, Maria Teresa, additional, Cornejo-Olivas, Mario, additional, Jimenez del Rio, Marlene, additional, Koretsky, Mathew, additional, Rodriguez-Violante, Mayela, additional, Ellis, Melina, additional, Avenali, Micol, additional, Rentería, Miguel E., additional, Inca-Martines, Miguel z, additional, Nalls, Mike A., additional, Ibrahim Norlinah, Mohamed, additional, Umair, Muhammad, additional, Ip, Nancy, additional, Louie, Naomi, additional, Cheung, Nelson Yuk-Fai, additional, Mencacci, Niccolò Emanuele, additional, Wood, Nicholas, additional, Williams, Nigel, additional, Hattori, Nobutaka, additional, Abdul Murad, Nor Azian, additional, Ibrahim, Norlinah Mohamed, additional, Monchi, Oury, additional, Öztop Çakmak, Özgür, additional, Öztop Çakmak, Patricio Öztop Çakmak, additional, Lewis, Patrick Alfryn, additional, Pastor, Pau, additional, Reyes-Pérez, Paula, additional, Saffie Awad, Paula, additional, Chana, Pedro, additional, Chan, Phillip, additional, Kung, Pin-Jui, additional, Chan, Piu, additional, Pal, Pramod, additional, Lingappa Kukkle, Prashanth, additional, Ojha, Rajeev, additional, Kaiyrzhanov, Rauan, additional, Krüger, Rejko, additional, Amouri, Rim, additional, Weil, Rimona, additional, Rajan, Roopa, additional, Alcalay, Roy, additional, Wu, Ruey-Meei, additional, Borgohain, Rupam, additional, Sassi, Samia Ben, additional, Khachatryan, Samson, additional, El-Sadig, Sarah, additional, Wu, Serena, additional, Groppa, Sergio, additional, Azmin, Shahrul, additional, Lim, Shen-Yang, additional, Ur-Rehman, Shoaib, additional, Ertan, Sibel, additional, Stott, Simon, additional, Jasaitye, Simona, additional, Chowdhury, Sohini, additional, Dumanis, Sonya, additional, Bardien, Soraya, additional, Lubbe, Steven, additional, Koks, Sulev, additional, Dey, Sumit, additional, Foroud, Tatiana, additional, Fon, Ted, additional, Beach, Thomas, additional, Gasser, Thomas, additional, Anderson, Tim, additional, Nguyen, Toan, additional, Schirinzi, Tommaso, additional, Shiraishi, Tomotaka, additional, Pitcher, Toni, additional, Tumas, Vitor, additional, Mohamed, Wael, additional, Kamel, Walaa A., additional, Luo, Wei, additional, Zhou, Xiaopu, additional, Zewde, Yared Z., additional, Song, Yeajin, additional, Wen, Yi, additional, Wu, Yihru, additional, Joong Kim, Yun, additional, and Tavadyan, Zaruhi, additional
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- 2023
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35. Development and Reliability of a User-Friendly Multicenter Phenotyping Application for Hemorrhagic and Ischemic Stroke
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Owolabi, Mayowa, Ogbole, Godwin, Akinyemi, Rufus, Salaam, Kehinde, Akpa, Onoja, Mongkolwat, Pattanasak, Omisore, Adeleye, Agunloye, Atinuke, Efidi, Richard, Odo, Joseph, Makanjuola, Akintomiwa, Akpalu, Albert, Sarfo, Fred, Owolabi, Lukman, Obiako, Reginald, Wahab, Kolawole, Sanya, Emmanuel, Adebayo, Philip, Komolafe, Morenikeji, Adeoye, Abiodun Moshood, Fawale, Michael B, Akinyemi, Joshua, Osaigbovo, Godwin, Sunmonu, Taofiki, Olowoyo, Paul, Chukwuonye, Innocent, Obiabo, Yahaya, Ibinaiye, Philip, Dambatta, Abdul, Mensah, Yaw, Abdul, Salaam, Olabinri, Eunice, Ikubor, Joyce, Oyinloye, Olalekan, Odunlami, Femi, Melikam, Ezinne, Saulson, Raelle, Kolo, Philip, Ogunniyi, Adesola, and Ovbiagele, Bruce
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- 2017
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36. Novel functional insights into ischemic stroke biology provided by the first genome-wide association study of stroke in indigenous Africans.
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Akinyemi, Rufus O., Tiwari, Hemant K., Srinivasasainagendra, Vinodh, Akpa, Onoja, Sarfo, Fred S., Akpalu, Albert, Wahab, Kolawole, Obiako, Reginald, Komolafe, Morenikeji, Owolabi, Lukman, Osaigbovo, Godwin O., Mamaeva, Olga A., Halloran, Brian A., Akinyemi, Joshua, Lackland, Daniel, Obiabo, Olugbo Y., Sunmonu, Taofik, Chukwuonye, Innocent I., Arulogun, Oyedunni, and Jenkins, Carolyn
- Subjects
GENOME-wide association studies ,LINCRNA ,ISCHEMIC stroke ,BIOLOGY ,NON-coding DNA ,NON-coding RNA - Abstract
Background: African ancestry populations have the highest burden of stroke worldwide, yet the genetic basis of stroke in these populations is obscure. The Stroke Investigative Research and Educational Network (SIREN) is a multicenter study involving 16 sites in West Africa. We conducted the first-ever genome-wide association study (GWAS) of stroke in indigenous Africans. Methods: Cases were consecutively recruited consenting adults (aged > 18 years) with neuroimaging-confirmed ischemic stroke. Stroke-free controls were ascertained using a locally validated Questionnaire for Verifying Stroke-Free Status. DNA genotyping with the H3Africa array was performed, and following initial quality control, GWAS datasets were imputed into the NIH Trans-Omics for Precision Medicine (TOPMed) release2 from BioData Catalyst. Furthermore, we performed fine-mapping, trans-ethnic meta-analysis, and in silico functional characterization to identify likely causal variants with a functional interpretation. Results: We observed genome-wide significant (P-value < 5.0E−8) SNPs associations near AADACL2 and miRNA (MIR5186) genes in chromosome 3 after adjusting for hypertension, diabetes, dyslipidemia, and cardiac status in the base model as covariates. SNPs near the miRNA (MIR4458) gene in chromosome 5 were also associated with stroke (P-value < 1.0E−6). The putative genes near AADACL2, MIR5186, and MIR4458 genes were protective and novel. SNPs associations with stroke in chromosome 2 were more than 77 kb from the closest gene LINC01854 and SNPs in chromosome 7 were more than 116 kb to the closest gene LINC01446 (P-value < 1.0E−6). In addition, we observed SNPs in genes STXBP5-AS1 (chromosome 6), GALTN9 (chromosome 12), FANCA (chromosome 16), and DLGAP1 (chromosome 18) (P-value < 1.0E−6). Both genomic regions near genes AADACL2 and MIR4458 remained significant following fine mapping. Conclusions: Our findings identify potential roles of regulatory miRNA, intergenic non-coding DNA, and intronic non-coding RNA in the biology of ischemic stroke. These findings reveal new molecular targets that promise to help close the current gaps in accurate African ancestry-based genetic stroke's risk prediction and development of new targeted interventions to prevent or treat stroke. [ABSTRACT FROM AUTHOR]
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- 2024
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37. Factors associated with frequency of fruit and vegetable consumption among selected sub-Saharan African populations: evidence from the Cardiovascular H3Africa Innovation Resource Project.
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Okekunle, Akinkunmi Paul, Asowata, Osahon Jeffery, Akpa, Onoja Matthew, Fakunle, Adekunle Gregory, Chikowore, Tinashe, Mohamed, Shukri F, Obiako, Reginald, Komolafe, Morenikeji, Osaigbovo, Godwin O, Ogbole, Godwin, Arulogun, Oyedunni, Sarfo, Fred Stephen, Wahab, Kolawole, Owolabi, Lukman, Akinyemi, Joshua, Akpalu, Albert, Uvere, Ezinne, Akinyemi, Rufus, Jenkins, Carolyn, and Arnett, Donna K
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SUB-Saharan Africans ,VEGETABLES ,FRUIT ,DISEASE risk factors ,FAMILY history (Medicine) - Abstract
Background Frequent fruit and vegetable consumption is considered a promising dietary behaviour that protects health. However, most existing studies about the factors associated with this phenomenon among Africans are based on single-country reports, apart from one meta-regression combining smaller studies. This study harmonized large datasets and assessed factors associated with the frequency of fruit and vegetable consumption in this population. Methods Individual-level data on sociodemographics, lifestyle and diet from 20 443 participants across five African countries (Burkina Faso, Ghana, Kenya, South Africa and Nigeria), from the Stroke Investigative Research and Educational Network (SIREN) and Africa Wits-INDEPTH partnership for Genomic Research (AWI-Gen) studies, were harmonized. Total frequency of fruit and vegetable consumption (in portions/week) was classified as 'low' (≤6), 'moderate' (7–14) and 'high' (≥15). Adjusted odds ratios (aORs) and 95% confidence intervals (CIs) of factors associated with the total frequency of fruit and vegetable consumption (using 'low' consumption as the reference) were estimated using multinomial regression models. Results Mean age of participants was 54.3 ± 11.8 years, 10 641 (52.1%) were female, and the median (interquartile range) frequency of total fruit and vegetable consumption was 10.0 (4.0, 21.0) portions/week. Participants with a family history of cardiovascular disease [moderate (aOR, 0.92; 95% CI, 0.85, 1.00) and high (aOR, 0.85; 95% CI, 0.78, 0.92)], current smokers [moderate (aOR, 0.83; 95% CI, 0.74, 0.94) and high (aOR, 0.78; 95% CI, 0.69, 0.88)], current alcohol users [moderate (aOR, 0.92; 95% CI, 0.85, 1.00) and high (aOR, 0.82; 95% CI, 0.76, 0.89)] and physically inactive participants [moderate (aOR, 0.85; 95% CI, 0.75, 0.96) and high (aOR, 0.80; 95% CI, 0.70, 0.90)] were less likely to consume fruits and vegetables frequently. Conclusion Africans with lifestyle risk factors for cardiovascular disease were less likely to consume fruit and vegetables frequently. [ABSTRACT FROM AUTHOR]
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- 2024
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38. Management of Impulse Control and Related Disorders in Parkinson's Disease: An Expert Consensus.
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Debove, Ines, Paschen, Steffen, Amstutz, Deborah, Cardoso, Francisco, Corvol, Jean‐Christophe, Fung, Victor S.C., Lang, Anthony E., Martinez Martin, Pablo, Rodríguez‐Oroz, María C., Weintraub, Daniel, Krack, Paul, Deuschl, Günther, Sarfo, Fred Stephen, Akpalu, Albert Kwaku, Okubadejo, Njideka, Shalash, Ali Soliman, Hattori, Nobutaka, Lee, Jee‐Young, O'Sullivan, Sean, and Antonini, Angelo
- Abstract
Background: Impulse‐control and related behavioral disorders (ICBDs) significantly impact the lives of Parkinson's disease (PD) patients and caregivers, with lasting consequences if undiagnosed and untreated. While ICBD pathophysiology and risk factors are well‐studied, a standardized severity definition and treatment evidence remain elusive. Objective: This work aimed to establish international expert consensus on ICBD treatment strategies. To comprehensively address diverse treatment availabilities, experts from various continents were included. Methods: From 2021 to 2023, global movement disorders specialists engaged in a Delphi process. A core expert group initiated surveys, involving a larger panel in three iterations, leading to refined severity definitions and treatment pathways. Results: Experts achieved consensus on defining ICBD severity, emphasizing regular PD patient screenings for early detection. General treatment recommendations focused on continuous monitoring, collaboration with significant others, and seeking specialist advice for legal or financial challenges. For mild to severe ICBDs, gradual reduction in dopamine agonists was endorsed, followed by reductions in other PD medications. Second‐line treatment strategies included diverse approaches like reversing the last medication change, cognitive behavior therapy, subthalamic nucleus deep brain stimulation, and specific medications like quetiapine, clozapine, and antidepressants. The panel reached consensus on distinct treatment pathways for punding and dopamine dysregulation syndrome, formulating therapy recommendations. Comprehensive discussions addressed management strategies for the exacerbation of either motor or non‐motor symptoms following the proposed treatments. Conclusion: The consensus offers in‐depth insights into ICBD management, presenting clear severity criteria and expert consensus treatment recommendations. The study highlights the critical need for further research to enhance ICBD management. © 2024 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]
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- 2024
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39. Risk Assessment Score and Chi-Square Automatic Interaction Detection Algorithm for Hypertension Among Africans: Models From the SIREN Study.
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Asowata, Osahon J., Okekunle, Akinkunmi Paul, Akpa, Onoja M., Fakunle, Adekunle Gregory, Akinyemi, Joshua O., Komolafe, Morenikeji Adeyoyin, Sarfo, Fred Stephen, Akpalu, Albert K., Obiako, Reginald, Wahab, Kolawole W., Osaigbovo(Osawaru), Godwin O., Owolabi, Lukman F., Jenkins, Carolyn M., Calys-Tagoe, Benedict Nii Laryea, Arulogun, Oyedunni Sola, Ogbole, Godwin I., Ogah, Okechukwu Samuel, Lambert, Appiah T., Ibinaiye, Philip Oluleke, and Adebayo, Philip B.
- Abstract
BACKGROUND: This study aimed to develop a risk-scoring model for hypertension among Africans. METHODS: In this study, 4413 stroke-free controls were used to develop the risk-scoring model for hypertension. Logistic regression models were applied to 13 risk factors. We randomly split the dataset into training and testing data at a ratio of 80:20. Constant and standardized weights were assigned to factors significantly associated with hypertension in the regression model to develop a probability risk score on a scale of 0 to 1 using a logistic regression model. The model accuracy was assessed to estimate the cutoff score for discriminating hypertensives. RESULTS: Mean age was 59.9±13.3 years, 56.0% were hypertensives, and 8 factors, including diabetes, age =65 years, higher waist circumference, (BMI) =30 kg/m², lack of formal education, living in urban residence, family history of cardiovascular diseases, and dyslipidemia use were associated with hypertension. Cohen κ was maximal at =0.28, and a total probability risk score of =0.60 was adopted for both statistical weighting for risk quantification of hypertension in both datasets. The probability risk score presented a good performance--receiver operating characteristic: 64% (95% CI, 61.0-68.0), a sensitivity of 55.1%, specificity of 71.5%, positive predicted value of 70.9%, and negative predicted value of 55.8%, in the test dataset. Similarly, decision tree had a predictive accuracy of 67.7% (95% CI, 66.1-69.3) for the training set and 64.6% (95% CI, 61.0-68.0) for the testing dataset. CONCLUSIONS: The novel risk-scoring model discriminated hypertensives with good accuracy and will be helpful in the early identification of community-based Africans vulnerable to hypertension for its primary prevention. [ABSTRACT FROM AUTHOR]
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- 2023
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40. Stroke Investigative Research and Education Network: Community Engagement and Outreach within Phenomics Core
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Jenkins, Carolyn, Arulogun, Oyedunni Sola, Singh, Arti, Mande, Aliyu T., Ajayi, Eric, Benedict, Calys Tagoe, Ovbiagele, Bruce, Lackland, Daniel T., Sarfo, Fred Stephen, Akinyemi, Rufus, Akpalu, Albert, Obiako, Reginald, Melikam, Enzinne Sylvia, Laryea, Ruth, Shidali, Vincent, Sagoe, Kwamena, Ibinaiye, Philip, Fakunle, Adekunie Gregory, Owolabi, Lukman F., and Owolabi, Mayowa O.
- Abstract
Stroke is the leading cause of neurological hospital admissions in sub-Saharan Africa (SSA) and the second leading cause of death globally. The Stroke Investigative Research and Education Network [SIREN] seeks to comprehensively characterize the genomic, sociocultural, economic, and behavioral risk factors for stroke and to build effective teams for research to address and decrease the burden of stroke and other noncommunicable diseases in SSA. One of the first steps to address this goal is to effectively engage the communities that suffer the high burden of disease. The purpose of this article is to describe plans to elucidate information about knowledge, attitudes, beliefs, and practices about stroke and genomics from patients, caregivers, and local leaders, to recruit participation in research activities and dissemination of ongoing results, as well as to facilitate research uptake and impact within the broader communities of scientists, health professionals, policy makers, and others. We describe the (a) study sites and their communities; (b) plans for community advisory boards, focus groups, and surveys; (c) methods for data management in REDCap database; (d) analyses of qualitative data; (e) evaluation of community and public engagement across multiple sites and research teams in SSA and the United States; (f) use of RE-AIM for presentation of evaluation data; and (g) community indicators of success. This is the first of its kind public outreach engagement initiative to evaluate stroke and genomics in SSA, and has implications as a model for assessment in other high-stroke risk populations. [This article was also written by the SIREN Team.]
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- 2016
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41. Unraveling the risk factors for spontaneous intracerebral hemorrhage among West Africans
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Sarfo, Fred S., Ovbiagele, Bruce, Gebregziabher, Mulugeta, Akpa, Onoja, Akpalu, Albert, Wahab, Kolawole, Ogbole, Godwin, Akinyemi, Rufus, Obiako, Reginald, Komolafe, Morenikeji, Owolabi, Lukman, Lackland, Daniel, Arnett, Donna, Tiwari, Hemant, Markus, Hugh S., Akinyemi, Joshua, Oguntade, Ayodipupo, Fawale, Bimbo, Adeoye, Abiodun, Olugbo, Obiabo, Ogunjimi, Luqman, Osaigbovo, Godwin, Jenkins, Carolyn, Chukwuonye, Ijezie, Ajose, Olabamiji, Oyinloye, Lekan, Mutiso, Fedelis, Laryea, Ruth, Calys-Tagoe, Benedict, Salaam, Abdul, Amusa, Ganiyu, Olowookere, Samuel, Imoh, Chidiebere, Mande, Aliyu, Arulogun, Oyedunni, Adekunle, Fakunle, Appiah, Lambert, Balogun, Olayemi, Singh, Arti, Adeleye, Osi, Ogah, Okechukwu, Makanjuola, Akintomiwa, Owusu, Dorcas, Kolo, Philip, Adebayo, Oladimeji, Agunloye, Atinuke, Shidali, Vincent, Faniyan, Moyinoluwalogo, Lakoh, Sulaiman, Diala, Samuel, Iheonye, Henry, Efidi, Chika, Sanya, Emmanuel, Sunmonu, Taofiki, Akintunde, Adeseye, and Owolabi, Mayowa
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- 2020
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42. Guillain-Barre syndrome and pulmonary embolism in an adult female with COVID-19 infection in Ghana: A case report
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Tetteh-Wayoe, Eugene, primary, Duodu, Fiifi, additional, Pekyi-Boateng, Prince Kwabla, additional, Agyeman Badu, Nana Boakye, additional, Akpalu, Albert, additional, and Adjei, Patrick, additional
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- 2023
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43. Correction to: African Control of Hypertension through Innovative Epidemiology and a Vibrant Ecosystem (ACHIEVE): novel strategies for accelerating hypertension control in Africa
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Owolabi, Mayowa, primary, Olowoyo, Paul, additional, Mocumbi, Ana, additional, Ogah, Okechukwu S., additional, Odili, Augustine, additional, Wahab, Kolawole, additional, Ojji, Dike, additional, Adeoye, Abiodun M., additional, Akinyemi, Rufus, additional, Akpalu, Albert, additional, Obiako, Reginald, additional, Sarfo, Fred S., additional, Bavuma, Charlotte, additional, Beheiry, Hind Mamoun, additional, Ibrahim, Moshen, additional, El Aroussy, Wafaa, additional, Parati, Gianfranco, additional, Dzudie, Anastase, additional, Singh, Sandhya, additional, Akpa, Onoja, additional, Kengne, Andre Pascal, additional, Okekunle, Akinkunmi Paul, additional, de Graft Aikins, Ama, additional, Agyemang, Charles, additional, Ogedegbe, Gbenga, additional, Ovbiagele, Bruce, additional, Garg, Renu, additional, Campbell, Norman R. C., additional, Lackland, Daniel T., additional, Barango, Prebo, additional, Slama, Slim, additional, Varghese, Cherian V., additional, Whelton, Paul K., additional, and Zhang, Xin-Hua, additional
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- 2023
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44. In-hospital Delays of Acute Ischaemic Stroke Treatment and Their Influence on Outcomes in Korle Bu Teaching Hospital, Ghana (P7-5.004)
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Duodu, Fiifi, primary, Mends, David, additional, Agbinko-Djobalar, Babbel, additional, Pekyi-Boateng, Prince, additional, Nkromah, Kodwo, additional, Adjei, Patrick, additional, and Akpalu, Albert, additional
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- 2023
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45. African Control of Hypertension through Innovative Epidemiology and a Vibrant Ecosystem (ACHIEVE): novel strategies for accelerating hypertension control in Africa
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Owolabi, Mayowa, primary, Olowoyo, Paul, additional, Mocumbi, Ana, additional, Ogah, Okechukwu S., additional, Odili, Augustine, additional, Wahab, Kolawole, additional, Ojji, Dike, additional, Adeoye, Abiodun M., additional, Akinyemi, Rufus, additional, Akpalu, Albert, additional, Obiako, Reginald, additional, Sarfo, Fred S., additional, Bavuma, Charlotte, additional, Beheiry, Hind Mamoun, additional, Ibrahim, Moshen, additional, El Aroussy, Wafaa, additional, Parati, Gianfranco, additional, Dzudie, Anastase, additional, Singh, Sandhya, additional, Akpa, Onoja, additional, Kengne, Andre Pascal, additional, Okekunle, Akinkunmi Paul, additional, de Graft Aikins, Ama, additional, Agyemang, Charles, additional, Ogedegbe, Gbenga, additional, Ovbiagele, Bruce, additional, Garg, Renu, additional, Campbell, Norman R. C., additional, Lackland, Daniel T., additional, Barango, Prebo, additional, Slama, Slim, additional, Varghese, Cherian V., additional, Whelton, Paul K., additional, and Zhang, Xin-Hua, additional
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- 2023
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46. Development and validation of a diagnostic aid for convulsive epilepsy in sub-Saharan Africa: a retrospective case-control study
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Jones, Gabriel Davis, primary, Kariuki, Symon M, additional, Ngugi, Anthony K, additional, Mwesige, Angelina Kakooza, additional, Masanja, Honorati, additional, Owusu-Agyei, Seth, additional, Wagner, Ryan, additional, Cross, J Helen, additional, Sander, Josemir W, additional, Newton, Charles R, additional, Sen, Arjune, additional, Abban, Hanna, additional, Adjei, Patrick, additional, Ae-Ngibise, Ken, additional, Agbokey, Francis, additional, Aissaoui, Lisa, additional, Akpalu, Albert, additional, Akpalu, Bright, additional, Asiamah, Sabina, additional, Asiki, Gershim, additional, Atieno, Mercy, additional, Bauni, Evasius, additional, Bhwana, Dan, additional, Bitta, Mary, additional, Bottomley, Christian, additional, Chabi, Martin, additional, Chengo, Eddie, additional, Chowdhary, Neerja, additional, Connor, Myles, additional, Cross, Helen, additional, Collinson, Mark, additional, Darkwa, Emmanuel, additional, Denison, Timothy, additional, Doku, Victor, additional, Dua, Tarun, additional, Egesa, Isaac, additional, Godi, Tony, additional, Gómez-Olivé, F. Xavier, additional, Grassi, Simone, additional, Iddi, Samuel, additional, Junior, Daniel Nana Yaw Abankwah, additional, Kahn, Kathleen, additional, Kakooza, Angelina, additional, Kariuki, Symon, additional, Kamuyu, Gathoni, additional, Khalayi, Clarah, additional, Kimambo, Henrika, additional, Kleinschmidt, Immo, additional, Kwasa, Thomas, additional, Mahone, Sloan, additional, Manolova, Gergana, additional, Mathew, Alexander, additional, Matuja, William, additional, McDaid, David, additional, Mmbando, Bruno, additional, Mtai Mwanga, Daniel, additional, Muli, Dorcas, additional, Mung'ala Odera, Victor, additional, Murunga Wekesah, Frederick, additional, Mushi, Vivian, additional, Ngugi, Anthony, additional, Odermatt, Peter, additional, Odhiambo, Rachael, additional, O Mageto, James, additional, Otieno, Peter, additional, Pariyo, George, additional, Peterson, Stefan, additional, Sander, Josemir, additional, Sottie, Cynthia, additional, Sylvester, Isolide, additional, Tollman, Stephen, additional, Thoya, Yvonne, additional, Twine, Rhian, additional, Vallentin, Sonia, additional, Walker, Richard, additional, and Waruingi, Stella, additional
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- 2023
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47. Capacity-Building for Stroke Genomic Research Data Collection: The African Neurobiobank Ethical, Legal, and Social Implications Project Experience
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Uvere, Ezinne O., primary, Nichols, Michelle, additional, Ojebuyi, Babatunde R., additional, Isah, Suleiman Yahaya, additional, Calys-Tagoe, Benedict, additional, Jenkins, Carolyn, additional, Obiako, Reginald, additional, Owolabi, Lukman, additional, Akpalu, Albert, additional, Sarfo, Fred Stephen, additional, Ogunronbi, Olumayowa, additional, Adigun, Muyiwa, additional, Fakunle, Gregory Adekunle, additional, Hamzat, Bello, additional, Laryea, Ruth, additional, Uthman, Babatunde, additional, Akinyemi, Joshua O., additional, Adeleye, Osi, additional, Melikam, Lois, additional, Balogun, Olubukola, additional, Sule, Abdullateef, additional, Adeniyi, Sunday, additional, Asibey, Shadrack O., additional, Oguike, Wisdom, additional, Olorunsogbon, Olorunyomi, additional, Singh, Arti, additional, Titiloye, Musibau A., additional, Musbahu, Rabiu, additional, Wahab, Kolawole W., additional, Kalaria, Rajesh N., additional, Jegede, Ayodele S., additional, Owolabi, Mayowa O., additional, Ovbiagele, Bruce, additional, Arulogun, Oyedunni S., additional, and Akinyemi, Rufus O., additional
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- 2023
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48. Profile of neurological disorders in an adult neurology clinic in Kumasi, Ghana
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Sarfo, Fred Stephen, Akassi, John, Badu, Elizabeth, Okorozo, Aham, Ovbiagele, Bruce, and Akpalu, Albert
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- 2016
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49. Validation of the 8-item questionnaire for verifying stroke free status with and without pictograms in three West African languages
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Sarfo, Fred S., Gebregziabher, Mulugeta, Ovbiagele, Bruce, Akinyemi, Rufus, Owolabi, Lukman, Obiako, Reginald, Armstrong, Kevin, Arulogun, Oyedunni, Akpalu, Albert, Melikam, Sylvia, Saulson, Raelle, Jenkins, Carolyn, and Owolabi, Mayowa
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- 2016
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50. African Control of Hypertension through Innovative Epidemiology and a Vibrant Ecosystem (ACHIEVE): novel strategies for accelerating hypertension control in Africa
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Owolabi, Mayowa, Olowoyo, Paul, Mocumbi, Ana, Ogah, Okechukwu S., Odili, Augustine, Wahab, Kolawole, Ojji, Dike, Adeoye, Abiodun M., Akinyemi, Rufus, Akpalu, Albert, Obiako, Reginald, Sarfo, Fred S., Bavuma, Charlotte, Beheiry, Hind Mamoun, Ibrahim, Moshen, El Aroussy, Wafaa, Parati, Gianfranco, Dzudie, Anastase, Singh, Sandhya, Akpa, Onoja, Kengne, Andre Pascal, Okekunle, Akinkunmi Paul, de Graft Aikins, Ama, Agyemang, Charles, Ogedegbe, Gbenga, Ovbiagele, Bruce, Garg, Renu, Campbell, Norman R. C., Lackland, Daniel T., Barango, Prebo, Slama, Slim, Varghese, Cherian V., Whelton, Paul K., and Zhang, Xin-Hua
- Abstract
Hypertension is a leading preventable and controllable risk factor for cardiovascular and cerebrovascular diseases and the leading preventable risk for death globally. With a prevalence of nearly 50% and 93% of cases uncontrolled, very little progress has been made in detecting, treating, and controlling hypertension in Africa over the past thirty years. We propose the African Control of Hypertension through Innovative Epidemiology and a Vibrant Ecosystem (ACHIEVE) to implement the HEARTS package for improved surveillance, prevention, treatment/acute care of hypertension, and rehabilitation of those with hypertension complications across the life course. The ecosystem will apply the principles of an iterative implementation cycle by developing and deploying pragmatic solutions through the contextualization of interventions tailored to navigate barriers and enhance facilitators to deliver maximum impact through effective communication and active participation of all stakeholders in the implementation environment. Ten key strategic actions are proposed for implementation to reduce the burden of hypertension in Africa.
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- 2024
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