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The question of aesthetic value remains a source of tension within diverse film education environments. While film-makers and audiences have visceral experiences of the value of cinema, these experiences are troubled by a contemporary film studies that tends to adopt a more relativist approach, suggesting that the experience of value is reflective of sociocultural subjectivity. Speaking from two different perspectives, Alan Bernstein and Andrew Burn explore the role of value in film education, and film culture more widely, in 2019. While Bernstein argues for a reinstatement of value as a fundamental aspect of how film is experienced and understood in educational contexts and beyond, Burn contextualizes questions of value within a wider framework of semiotic and aesthetic theory, arguing for a multimodal approach that takes into account the multifaceted nature of film.

After PhD studies at the University of Toronto, and postdoctoral work in London, Alan worked at the Ontario Cancer Institute and then the Samuel Lunenfeld Research Institute (eventually as Director of Research). As inaugural president of the Canadian Institutes of Health Research (CIHR; 2000–2007), he led the transformation of health research in Canada and an almost tripling of the budget for health research. He then was named executive director of the Global HIV Vaccine Enterprise (2008–2012). Since 2012, Alan has been president of CIFAR, Canada’s global research institute, where he has led major initiatives to increase CIFAR’s programs of research and global impact, and launched new programs to nurture the world’s next generation of researchers. Author of 250 scientific and 50 op-ed and lay publications, Alan has received numerous awards and honors, including induction into the Orders of Canada and Ontario, honorary degrees, the Gairdner Wightman Award, induction into the Canadian Medical Hall of Fame and the Henry Friesen International Prize.

Launch a global clean-energy initiative to set priorities that galvanize researchers to deliver breakthroughs, write Alan Bernstein and colleagues.

The protooncogene Vav functions as a GDP/GTP exchange factor (GEF) for Rho-like small GTPases involved in cytoskeletal reorganization and cytokine production in T cells. Gene-targeted mice lacking Vav have a severe defect in positive and negative selection of T cell antigen receptor transgenic thymocytes in vivo, and vav−/− thymocytes are completely resistant to peptide-specific and anti-CD3/anti-CD28–mediated apoptosis. Vav acts upstream of mitochondrial pore opening and caspase activation. Biochemically, Vav regulates peptide-specific Ca2+ mobilization and actin polymerization. Peptide-specific cell death was blocked both by cytochalasin D inhibition of actin polymerization and by inhibition of protein kinase C (PKC). Activation of PKC with phorbol ester restored peptide-specific apoptosis in vav−/− thymocytes. Vav was found to bind constitutively to PKC-θ in thymocytes. Our results indicate that peptide-triggered thymocyte apoptosis is mediated via Vav activation, changes in the actin cytoskeleton, and subsequent activation of a PKC isoform.