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Your search keyword '"Alicia Villavicencio"' showing total 4 results
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4 results on '"Alicia Villavicencio"'

1. CD200 genotype is associated with clinical outcome of patients with multiple myeloma

Author

Yolanda Gonzalez-Montes, Gemma Osca-Gelis, Rocío Rodriguez-Romanos, Alicia Villavicencio, Marta González-Bártulos, Francesca Llopis, Victòria Clapes, Albert Oriol, Anna Sureda, Lourdes Escoda, Josep Sarrà, Ana Garzó, Natàlia Lloveras, Beatriz Gómez, Isabel Granada, and David Gallardo

Subjects
CD200 polymorphisms, multiple myeloma, immune checkpoint, bone marrow microenvironment, immune disfunction, Immunologic diseases. Allergy, RC581-607
Abstract

Immune dysfunction in patients with MM affects both the innate and adaptive immune system. Molecules involved in the immune response pathways are essential to determine the ability of cancer cells to escape from the immune system surveillance. However, few data are available concerning the role of immune checkpoint molecules in predicting the myeloma control and immunological scape as mechanism of disease progression. We retrospectively analyzed the clinical impact of the CD200 genotype (rs1131199 and rs2272022) in 291 patients with newly diagnosed MM. Patients with a CD200 rs1131199 GG genotype showed a median overall survival (OS) significantly lower than those with CC+CG genotype (67.8 months versus 94.4 months respectively; p: 0.022) maintaining significance in the multivariate analysis. This effect was specially detected in patients not receiving an autologous stem cell transplant (auto-SCT) (p < 0.001). In these patients the rs1131199 GG genotype negatively influenced in the mortality not related with the progression of MM (p: 0.02) mainly due to infections events.

Published
2024
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2. Genetic variants of CTLA4 are associated with clinical outcome of patients with multiple myeloma

Author

Yolanda Gonzalez-Montes, Rocío Rodriguez-Romanos, Alicia Villavicencio, Gemma Osca-Gelis, Marta González-Bártulos, Francesca Llopis, Victòria Clapes, Albert Oriol, Anna Sureda, Lourdes Escoda, Josep Sarrà, Ana Garzó, Natàlia Lloveras, Isabel Díez, Isabel Granada, and David Gallardo

Subjects
CTLA4 polymorphisms, multiple myeloma, immune checkpoint, bone marrow microenvironment, cytogenetics and molecular genetics, Immunologic diseases. Allergy, RC581-607
Abstract

Immune dysfunction in patients with multiple myeloma (MM) affects both the innate and adaptive immune system. Molecules involved in the immune checkpoint pathways are essential to determine the ability of cancer cells to escape from the immune system surveillance. However, few data are available concerning the role of these molecules in predicting the kinetics of progression of MM. We retrospectively analysed polymorphisms of CTLA4 (rs231775 and rs733618), BTLA (rs9288953), CD28 (rs3116496), PD-1 (rs36084323 and rs11568821) and LAG-3 (rs870849) genes in 239 patients with newly diagnosed MM. Patients with a CTLA4 rs231775 AA/AG genotype showed a median progression-free survival (PFS) significantly lower than those with GG genotype (32.3 months versus 96.8 months respectively; p: 0.008). The 5-year PFS rate was 25% for patients with grouped AA and AG genotype vs 55.4% for patients with GG genotype. Multivariate analysis confirmed the CTLA4 rs231775 genotype as an independent risk factor for PFS (Hazard Ratio (HR): 2.05; 95% CI: 1.0-6.2; p: 0.047). Our results suggest that the CTLA4 genotype may identify patients with earlier progression of MM. This polymorphism could potentially be used as a prognostic biomarker.

Published
2023
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4. Effect of the Application of Microorganisms on the Nutrient Absorption in Avocado (Persea americana Mill.) Seedlings

Author

Kang Jin Cho, Trevor A. Jackson, Alicia Villavicencio, Andrea Sotomayor, Antonio Gonzáles, and William Viera

Subjects
0106 biological sciences, 0303 health sciences, Persea, biology, Inoculation, fungi, food and beverages, Trichoderma harzianum, biology.organism_classification, 01 natural sciences, Crop, 03 medical and health sciences, Horticulture, Trichoderma, Cultivar, Rootstock, Plant nutrition, 030304 developmental biology, 010606 plant biology & botany
Abstract

Avocado is a fruit crop of high economic importance for Ecuador, both locally and for exportation. Fuerte and Hass varieties are cultivated, both of which are grafted onto rootstocks from the cultivar Criollo. The growth of rootstocks in the nursery is a critical stage in the production of avocado plants, and application of beneficial microorganisms could be used to improve plant nutrition and growth of the rootstocks. In this research, the effect of inoculation of Trichoderma harzianum or Glomus iranicum var. tenuihypharum on avocado rootstock seedlings (cultivar Criollo) was evaluated. Application of T. harzianum significantly increased the absorption of N5+ and Mg2+ in the roots; while in the aerial parts (leaves and stem), it increased the absorption of N5+, Ca2+, Mg2+, Mn2+ and Cu2+. On the other hand, G. iranicum var. tenuihypharum significantly increased the absorption of Ca2+ and Fe3+ in the root; but no major effect was observed in the aerial part. However, a positive tendency toward an increase in the amount of P5+ was observed in the root; while in the aerial part this trend was observed for N3- and Ca2+ absorption. Neither of the two microorganisms influenced the absorption of S4+, an element that was present at stable levels in the whole plant. In conclusion, the applied microorganisms produced an increase in absorption of several macro and micronutrient in Criollo avocado rootstock seedlings.

Published
2019

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