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Danah Abdullah Albarrak,1 Abdulrahman Bandar Alotaibi,2 Roaa Faisal Alotaibi,3 Sara Hussain Alramadhan,3 Alhanouf Ibrahim Bin Muhanna,1 Abdulrahman Mohammed Aldehan,2 Khalid A Bin Abdulrahman4 1College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; 2Department of Medicine, College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, 13317, Saudi Arabia; 3Department of Medicine, College of Medicine, AlMaarefa University, Ad Diriyah, 13713, Saudi Arabia; 4Department of Medical Education, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 13317-4233, Saudi ArabiaCorrespondence: Abdulrahman Bandar Alotaibi, Department of Medicine, College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, 13317, Saudi Arabia, Email abdulrahmanbto@gmail.comBackground: High prevalence of mental disorders is associated with psychoactive substances, significantly contributing to morbidity, disability, and premature mortality. Worldwide, individuals who use electronic-cigarettes (EC) and have a mental health diagnosis are more likely to experience stress, depression, and drug use. This study aims to measure the prevalence of both EC use and mental health disorders namely, anxiety and depression additionally to investigate the association between EC use and mental health status among the general population of Saudi Arabia.Methods: A cross-sectional analytical study was conducted across Saudi Arabia from November 2022 to May 2023. The survey was divided into three sections. The first section focuses on the demographics, while the second part asked about both conventional and EC smoking and their frequency. The third section assessed mental health status using a Patient Health Questionnaire with a 9-item depression scale (PHQ-9) and a 7-item Generalized Anxiety Disorder scale (GAD-7).Results: The study revealed 21.1% reporting EC use in the past thirty days. While 19.8% reported smoking tobacco one