1. Identification of oligopeptides from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non structural protein 8 (NSP8) and their similarities with type 1 angiotensin II receptor key sites
- Author
-
Ammar Achour
- Subjects
0301 basic medicine ,ACE-2, angiotensin-converting enzyme 2 ,SARS-CoV-2, severe severe acute respiratory syndrome coronavirus 2 ,NSP8 ,Angiotensin receptor ,AT1R, angiotensin II type 1 receptor ,G protein ,Short Communication ,Cellular homeostasis ,RM1-950 ,a.a, amino acids ,Viral Nonstructural Proteins ,AT1R ,Receptor, Angiotensin, Type 1 ,Cpp, cell penetrating peptide ,03 medical and health sciences ,0302 clinical medicine ,Mediator ,Desensitization (telecommunications) ,Sarscov-2 ,Humans ,Amino Acid Sequence ,Receptor ,Covid 19, Coronavirus disease 2019 ,Pharmacology ,Ang II, angiotensin II ,Coronavirus RNA-Dependent RNA Polymerase ,SARS-CoV-2 ,Chemistry ,COVID-19 ,similarity Angiotensin II ,General Medicine ,Angiotensin II ,NSP8, non structural protein 8 ,Cell biology ,ORF1ab, open reading frame 1ab ,030104 developmental biology ,030220 oncology & carcinogenesis ,peptides ,Phosphorylation ,LPS, lipopolysaccharides ,Therapeutics. Pharmacology ,Oligopeptides - Abstract
Coronavirus disease 2019 is associated with clinical symptoms including severe inflammatory syndrome and a higher expression of angiotensin II. As a pro-inflammatory mediator, the physiologic effects of angiotensin II are mediated by a G-protein coupled receptor, termed AT1R. Following binding, AT1R initiates the process of signal desensitization necessary to maintain cellular homeostasis. At the cellular level, this function occurs via the G protein-dependent signaling and the phosphorylation. We describe amino acids similarities between SARS COV-2 nonstructural protein (NSP8) which is associated with intracellular membranes and AT1R key sites. Since abnormal activation of AT1R receptor leads to a number of physiological disorders, we hypothesize that SARS COV-2 might further interfere with the angiotensin II receptor functions.
- Published
- 2021