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Your search keyword '"Andrade, Sérgio Faloni de"' showing total 17 results
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17 results on '"Andrade, Sérgio Faloni de"'

1. Maytenus robusta Reissek, a medicinal plant popularly used to treat digestive diseases, promotes ameliorative effects in colon and liver of mice exposed to dextran sulfate sodium

Author

Mees, Mariéli, Meurer, Marianne Caroline, Mariano, Luísa Nathalia Bolda, Boeing, Thaise, Somensi, Lincon Bordignon, Mariott, Marihá, Niero, Rivaldo, Cechinel-Filho, Valdir, Andrade, Sérgio Faloni de, Duarte, Lucienir Pains, Sousa, Grasiely Faria de, de Souza, Priscila, and Da Silva, Luísa Mota

Published
2020
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5. Antiarthritic and Antihyperalgesic Properties of Ethanolic Extract from Gomphrena celosioides Mart. (Amaranthaceae) Aerial Parts

Author

Macorini, Luis Fernando Benitez, primary, Radai, Joyce Alencar Santos, additional, Maris, Rafael Souza, additional, Silva-Filho, Saulo Euclides, additional, Leitao, Maicon Matos, additional, Andrade, Sérgio Faloni de, additional, Gelves, Dayanna Isabel Araque, additional, Salvador, Marcos Jose, additional, Arena, Arielle Cristina, additional, and Kassuya, Cândida Aparecida Leite, additional

Published
2020
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8. Artepillin C, drupanin, aromadendrin-4′-O-methyl-ether and kaempferide from Brazilian green propolis promote gastroprotective action by diversified mode of action

Author

Costa, Philipe, primary, Almeida, Marilia O., additional, Lemos, Marivane, additional, Arruda, Caroline, additional, Casoti, Rosana, additional, Somensi, Lincon Bordignon, additional, Boeing, Thaise, additional, Mariott, Marihá, additional, da Silva, Rita de Cássia Melo Vilhena de Andrade Fonseca, additional, Stein, Bruna De Paoli, additional, Souza, Priscila de, additional, dos Santos, Ana Caroline, additional, Bastos, Jairo K., additional, da Silva, Luísa Mota, additional, and Andrade, Sérgio Faloni de, additional

Published
2018
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9. Sex-specific effects ofEugenia punicifoliaextract on gastric ulcer healing in rats

Author

Périco, Larissa Lucena, primary, Rodrigues, Vinícius Peixoto, additional, Ohara, Rie, additional, Bueno, Gabriela, additional, Nunes, Vânia Vasti Alfieri, additional, Santos, Raquel de Cássia dos, additional, Camargo, Ana Carolina Lima, additional, Júnior, Luis Antônio Justulin, additional, Andrade, Sérgio Faloni de, additional, Steimbach, Viviane Miranda Bispo, additional, Silva, Luísa Mota da, additional, Rocha, Lúcia Regina Machado da, additional, Vilegas, Wagner, additional, Santos, Catarina dos, additional, and Hiruma-Lima, Clélia Akiko, additional

Published
2018
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10. SCREENING OF WILD FRUIT TREES WITH GASTROPROTECTIVE ACTIVITY IN DIFFERENT EXPERIMENTAL MODELS

Author

NESELLO, Luciane Angela Nottar, CAMPOS, Adriana, ROSA, Roseane Leandra da, ANDRADE, Sérgio Faloni de, and CECHINEL FILHO, Valdir

Subjects
Ethanol, Etanol, Phytochemicals, Indomethacin, Compostos fitoquímicos, Gastroenteropatias, Gastrointestinal diseases, Indometacina
Abstract

BACKGROUND Given the increase of people with gastrointestinal disorders, the search for alternative treatments with fewer side effects is vital, as well as the demand for food or plants that can help protect the stomach. OBJECTIVE The aim of this study was to evaluate the gastroprotective action of the extracts of wild fruit trees of Myrcianthes pungens (guabiju); Inga vera Willd. (ingá-banana) and Marlierea tomentosa Cambess. (guarapuruna) in in vivo pharmacological models. METHODS The different parts of the fruits were separately subjected to a process of extraction by methanol. Two experimental pharmacological models were conducted in mice; the gastric ulcer model induced by non-steroidal anti-inflammatory (indomethacin), and the gastric ulcer model induced by ethanol/HCl, which allowed us to evaluate the gastroprotective activity of the extracts at a dose of 250 mg/kg. Subsequently, the total lesion area (mm2) and relative lesion area (%) were determined. RESULTS The results showed significant gastroprotective activity against the aggressive agents used - ethanol and indomethacin - for all the extracts tested. CONCLUSION It is assumed that the fruits have bioactive compounds such as antioxidant substances that act on the prostaglandin levels, protecting them from the damage caused by ethanol and indomethacin. These results prompt further studies to isolate and identify the active properties. RESUMO CONTEXTO Devido ao aumento de pessoas com distúrbios gastrointestinais, a busca de tratamentos alternativos com menos efeitos colaterais é fundamental, assim como a demanda por alimentos ou plantas que possam ajudar a proteger o estômago. OBJETIVO O presente estudo teve como objetivo avaliar a ação gastroprotetora dos extratos plantas frutíferas silvestres Myrcianthes pungens (guabiju); Inga vera Willd. (ingá-banana) e Marlierea tomentosa Cambess. (guarapuruna) em modelos farmacológicos in vivo. MÉTODOS As diferentes partes do fruto foram submetidas separadamente a um processo de maceração em solução metanólica a frio. Foram realizados dois modelos experimentais em camundongos, modelo de úlcera gástrica induzida por anti-inflamatório não-esteroidal (indometacina) e modelo de úlcera gástrica induzida por etanol/HCl, que permitiram avaliar a atividade gastroprotetora dos extratos na dose de 250 mg/kg. Posteriormente, foram determinadas a área total de lesão (mm2) e a área relativa lesada (%). RESULTADOS Os resultados apresentaram atividade gastroprotetora significativa para todos os extratos estudados frente aos agentes agressores utilizados, etanol e indometacina. CONCLUSÃO Supõe-se que os frutos apresentam compostos bioativos, como as substancias antioxidantes, que atuam sobre os níveis de prostaglandinas, protegendo dos danos causados pelo etanol e indometacina. Os resultados encorajam futuros estudos para isolamento e identificação dos princípios ativos dos frutos.

Published
2017

12. Prolonged diuretic and saluretic effect of nothofagin isolated from Leandra dasytricha (A. Gray) Cogn. leaves in normotensive and hypertensive rats: Role of antioxidant system and renal protection

Author

de Almeida, Camila Leandra Bueno, primary, Cechinel-Filho, Valdir, additional, Boeing, Thaise, additional, Mariano, Luísa Nathália Bolda, additional, Silva, Luísa Mota da, additional, Andrade, Sérgio Faloni de, additional, and de Souza, Priscila, additional

Published
2018
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13. Influence of Prostanoids in the Diuretic and Natriuretic Effects of Extracts and Kaempferitrin fromBauhinia forficataLink Leaves in Rats

Author

de Souza, Priscila, primary, da Silva, Luisa Mota, additional, Boeing, Thaise, additional, Somensi, Lincon Bordignon, additional, Cechinel-Zanchett, Camile Cecconi, additional, Campos, Adriana, additional, Krueger, Clarissa de Medeiros Amorim, additional, Bastos, Jairo Kenupp, additional, Cechinel-Filho, Valdir, additional, and Andrade, Sérgio Faloni de, additional

Published
2017
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14. Diuretic, natriuretic and potassium-sparing effect of nothofagin isolated from Leandra dasytricha (A. Gray) Cogn. leaves in normotensive and hypertensive rats

Author

de Almeida, Camila Leandra Bueno, primary, Boeing, Thaise, additional, Somensi, Lincon Bordignon, additional, Steimbach, Viviane Miranda Bispo, additional, da Silva, Luísa Mota, additional, Andrade, Sérgio Faloni de, additional, Delle Monache, Franco, additional, Cechinel-Filho, Valdir, additional, and de Souza, Priscila, additional

Published
2017
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16. Influence of Prostanoids in the Diuretic and Natriuretic Effects of Extracts and Kaempferitrin from Bauhinia forficata Link Leaves in Rats.

Author

Souza, Priscila, Silva, Luisa Mota, Boeing, Thaise, Somensi, Lincon Bordignon, Cechinel ‐ Zanchett, Camile Cecconi, Campos, Adriana, Krueger, Clarissa de Medeiros Amorim, Bastos, Jairo Kenupp, Cechinel ‐ Filho, Valdir, and Andrade, Sérgio Faloni de

Abstract

Although Bauhinia forficata Link is popularly used in Brazil to induce diuresis, no scientific investigation has focused on demonstrating its efficacy in preclinical trials. For that, normotensive male Wistar and spontaneously hypertensive rats were used to test the effect of extracts and kaempferitrin obtained from Bauhinia forficata leaves in the experimental model of diuresis. Cumulative urine volume, Na+ and K+ excretion, calcium, creatinine, prostaglandin E2 , pH, density, and conductivity were measured at the end of the experiment (after 8 or 24 h). The treatment with aqueous infusion, methanolic extract, trichloromethane, or ethyl acetate-butanolic fractions significantly increase urinary volume and electrolytes levels when orally given to rats, without altering the pH or density parameters. Kaempferitrin induced diuretic, natriuretic, but not kaliuretic effects in both normotensive and hypertensive rats. In addition, kaempferitrin enhanced urinary creatinine and prostaglandin E2 excretion, without modifying calcium levels. Kaempferitrin-induced diuresis was unaffected by previous treatment with a nonselective inhibitor of nitric oxide synthase and neither with a nonselective muscarinic receptor antagonist. On the other hand, a cyclooxygenase inhibitor was able to decrease its effect when compared with vehicle-treated rats, suggesting that the diuretic and natriuretic properties from kaempferitrin are associated with endogenous prostanoids generation. Copyright © 2017 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]

Published
2017
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17. In vivo evaluation of the genetic toxicity of Rubus niveus Thunb. (Rosaceae) extract and initial screening of its potential chemoprevention against doxorubicin-induced DNA damage

Author

Tolentino, Flora, primary, Araújo, Priscila Alves de, additional, Marques, Eduardo de Souza, additional, Petreanu, Marcel, additional, Andrade, Sérgio Faloni de, additional, Niero, Rivaldo, additional, Perazzo, Fábio F., additional, Rosa, Paulo César Pires, additional, and Maistro, Edson Luis, additional

Published
2015
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