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Background Numerous case reports and case series have described brain Magnetic Resonance Imaging (MRI) findings in Coronavirus disease 2019 (COVID-19) patients with concurrent posterior reversible encephalopathy syndrome (PRES). Purpose We aim to compile and analyze brain MRI findings in patients with COVID-19 disease and PRES. Methods PubMed and Embase were searched on April 5th, 2021 using the terms “COVID-19”, “PRES”, “SARS-CoV-2” for peer-reviewed publications describing brain MRI findings in patients 21 years of age or older with evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and PRES. Results Twenty manuscripts were included in the analysis, which included descriptions of 30 patients. The average age was 57 years old. Twenty-four patients (80%) required mechanical ventilation. On brain MRI examinations, 15 (50%) and 7 (23%) of patients exhibited superimposed foci of hemorrhage and restricted diffusion respectively. Conclusions PRES is a potential neurological complication of COVID-19 related disease. COVID-19 patients with PRES may exhibit similar to mildly greater rates of superimposed hemorrhage compared to non-COVID-19 PRES patients.

The coronavirus disease 2019 (COVID -19) pandemic caused by the novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has affected almost every country in the world, resulting in severe morbidity, mortality and economic hardship, and altering the landscape of healthcare forever. Although primarily a pulmonary illness, it can affect multiple organ systems throughout the body, sometimes with devastating complications and long-term sequelae. As we move into the second year of this pandemic, a better understanding of the pathophysiology of the virus and the varied imaging findings of COVID-19 in the involved organs is crucial to better manage this complex multi-organ disease and to help improve overall survival. This manuscript provides a comprehensive overview of the pathophysiology of the virus along with a detailed and systematic imaging review of the extra-thoracic manifestation of COVID-19 with the exception of unique cardiothoracic features associated with multisystem inflammatory syndrome in children (MIS-C). In Part I, extra-thoracic manifestations of COVID-19 in the abdomen in adults and features of MIS-C will be reviewed. In Part II, manifestations of COVID-19 in the musculoskeletal, central nervous and vascular systems will be reviewed.

Disasters are a primary influence in the global development landscape given their unequal impacts across society and calls for transformative change in their aftermath. Recovering from disasters is one component of development that is coming under scrutiny. This is especially so in the context of the COVID-19 pandemic, whose scale, scope, and cascading effects mean that the uncertain prospects for recovery will be complicated and endure long term. COVID-19 has forced a reappraisal of what recovery encompasses, who it is for, and how it can better enable preparedness for future disasters. Drawing upon interviews with a global community of experts specializing in different areas of disaster governance, this paper focuses on the lessons emerging for recovery-related theory and practice deriving from the pandemic. We elaborate a multi-dimensional framework to support those working on local recovery planning within communities and operating across different sectors. The framework captures the interconnected issues across six principal domains—communities, economic, infrastructure, environment, health, and governance—representing key impact areas around which strategies and multifaceted actions can be developed. We suggest a three-step process using a systems approach to develop a recovery strategy that operationalizes the framework and addresses the complexity of long-term recovery for development.

BackgroundResilience is a ubiquitous but often misunderstood term. It is often studied and described within the lens of individual academic disciplines, despite the complexities and interactions of today’s world. Using a meta-narrative approach, we performed a systematic literature review of healthcare resilience, tracking the research traditions which have informed this field. This paper consolidates knowledge about the definitions, measures, and concepts of healthcare resilience at meso- and macro-levels, to build an interdisciplinary, cross-sectoral, and multi-level (ICM) approach and framework. It forms part of a wider project on healthcare resilience, within a larger research group on societal resilience and guides efforts to build resilience after the COVID19 pandemic.MethodsForty-five reviews were analysed thematically, adhering to RAMESES and PRISMA guidelines. We explore issues inherent to fundamental terms and propose a unified definition spanning event timescales and applicable to multiple hierarchical levels. Studies tended to focus on individual hierarchical levels using a range of frameworks, which are frequently also used as measurement indices. Macro-level indices focusing on capacities failed to sufficiently capture the importance of relational aspects of systems resilience. Meso-level approaches and frameworks tended to swing between the extremes of disaster risk reduction strategies and patient safety approaches for normal stressors. Micro-level approaches were not a focus but tended to centre around acute psychological interventions.ResultsThe analysis allowed us to propose a unified definition and build an overall framework for healthcare resilience containing pre-, intra-, post-, and trans-event domains, which work across hierarchical levels. We also adopt a realist view by presenting a table of selected resilience frameworks, categorising them according to predominant hierarchical level and timescale. This aims to guide decision-makers about the suitability of various frameworks, at specific levels, through numerous points during crises. ConclusionThere is increasing acknowledgement of the need for inter-disciplinary, cross-sectoral, and multi-level approaches to healthcare resilience, but such work is hitherto rare. A realist approach to various resilience frameworks may help to determine best-fit for individual organisations and systems. There is a need to better understand how resilience practically works across various hierarchical levels.

The coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has affected almost every country in the world resulting in severe morbidity, mortality and economic hardship, altering the landscape of healthcare forever. Its devastating and most frequent thoracic and cardiac manifestations have been well reported since the start of the pandemic. Its extra-thoracic manifestations are myriad and understanding them is critical in diagnosis and disease management. The role of radiology is growing in the second wave and second year of the pandemic as the multiorgan manifestations of COVID-19 continue to unfold. Musculoskeletal, neurologic and vascular disease processes account for a significant number of COVID-19 complications and understanding their frequency, clinical sequelae and imaging manifestations is vital in guiding management and improving overall survival. The authors aim to provide a comprehensive overview of the pathophysiology of the virus along with a detailed and systematic imaging review of the extra-thoracic manifestation of COVID-19. In Part I, abdominal manifestations of COVID-19 in adults and multisystem inflammatory syndrome in children will be reviewed. In Part II, manifestations of COVID-19 in the musculoskeletal, central nervous and vascular systems will be reviewed.

ObjectiveSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is protean in its manifestations, affecting nearly every organ system. However, nervous system involvement and its effect on disease outcome are poorly characterized. The objective of this study was to determine whether neurologic syndromes are associated with increased risk of inpatient mortality.MethodsA total of 581 hospitalized patients with confirmed SARS-CoV-2 infection, neurologic involvement, and brain imaging were compared to hospitalized non-neurologic patients with coronavirus disease 2019 (COVID-19). Four patterns of neurologic manifestations were identified: acute stroke, new or recrudescent seizures, altered mentation with normal imaging, and neuro-COVID-19 complex. Factors present on admission were analyzed as potential predictors of in-hospital mortality, including sociodemographic variables, preexisting comorbidities, vital signs, laboratory values, and pattern of neurologic manifestations. Significant predictors were incorporated into a disease severity score. Patients with neurologic manifestations were matched with patients of the same age and disease severity to assess the risk of death.ResultsA total of 4,711 patients with confirmed SARS-CoV-2 infection were admitted to one medical system in New York City during a 6-week period. Of these, 581 (12%) had neurologic issues of sufficient concern to warrant neuroimaging. These patients were compared to 1,743 non-neurologic patients with COVID-19 matched for age and disease severity admitted during the same period. Patients with altered mentation (n = 258, p = 0.04, odds ratio [OR] 1.39, confidence interval [CI] 1.04–1.86) or radiologically confirmed stroke (n = 55, p = 0.001, OR 3.1, CI 1.65–5.92) had a higher risk of mortality than age- and severity-matched controls.ConclusionsThe incidence of altered mentation or stroke on admission predicts a modest but significantly higher risk of in-hospital mortality independent of disease severity. While other biomarker factors also predict mortality, measures to identify and treat such patients may be important in reducing overall mortality of COVID-19.

Assess the prevalence of white matter microstructural changes in combat veterans, within the context of a highly matched control group comprising unexposed close relatives. This prospective study had institutional review board approval, included written informed consent, and is HIPAA-compliant. Diffusion tensor imaging was analyzed in 16 male blast-exposed combat veterans of Operation Iraqi Freedom/Operation Enduring Freedom (mean age 31.0 years) and 18 unexposed males (mean age 30.4 years) chosen on the basis of a consanguineous relationship to a member of the subject group. Whole-brain voxel-based comparison of fractional anisotropy (FA) was performed using both group and individual analyses. Areas where effects on FA were detected were subsequently characterized by extracting radial diffusivity (RD), axial diffusivity (AD), and mean diffusivity (MD) from the regions of abnormal FA. Controls did not differ from veterans on any background demographic factor. In voxel-based group comparison, we identify high fractional anisotropy (FA) in veterans compared to controls (p

The cathedral city of Armagh is one of the most historically and architecturally significant on the island of Ireland. This article explores the preparation of an inventory of Armagh’s architectural heritage by the London architect-planner Max Lock in 1964, commissioned by the Northern Ireland Committee of the National Trust. The inventory represents one aspect of the initial response of civil society to impending change in the built environment in the mid-1960s and formed part of efforts to ensure parity with Great Britain in land-use planning legislation. The inventory facilitates a wider discussion on state-civil society relations in Northern Ireland, the values and ideas guiding change within historic settlements, and the place promotional advantage that the local council sought to derive from Armagh’s history and heritage. Utilizing Ward’s typology of diffusion, it is argued that Northern Ireland represents an unusual ‘within-UK’ example of the transference of planning ideas and practices, with its historical experience of devolution offering valuable contemporary insights into the increasingly diffuse and fragmented governance space within the UK.

Terence O’Neill maintained a keen interest in conservation and architectural heritage, but his record on these issues in government in Northern Ireland is largely unexamined. This article addresses this deficit through a comprehensive review of the existing literature reinforced by archival material, revealing the familial and other connections that O’Neill had with the conservation world and civil society organisations, including his sometimes behind-the-scenes interventions on conservation policy. The momentous impact on the existing built environment from his drive to ‘transform the face of Ulster’ is ultimately foregrounded, particularly the contemporary philosophy underpinning the ‘balanced approach’ to development that was initially favoured by progressive opinion in the early 1960s, and the effect that the destruction of familiar places had on the creation of new heritage values. However, the failure of O’Neill to introduce town and country planning legalisation akin to that existing in Great Britain frustrated the efforts of conservationists who grew increasingly vociferous in their calls for action. As in other contested areas of public policy in the 1960s in Northern Ireland, the destructive forces unleashed in the built environment threatened architectural heritage and essentially remained unchecked in the absence of timely reforms prior to Direct Rule from Westminster.

This article describes a maximum likelihood method for estimating the parameters of the standard square-root stochastic volatility model and a variant of the model that includes jumps in equity prices. The model is fitted to data on the S&P 500 Index and the prices of vanilla options written on the index, for the period 1990 to 2011. The method is able to estimate both the parameters of the physical measure (associated with the index) and the parameters of the risk-neutral measure (associated with the options), including the volatility and jump risk premia. The estimation is implemented using a particle filter whose efficacy is demonstrated under simulation. The computational load of this estimation method, which previously has been prohibitive, is managed by the effective use of parallel computing using graphics processing units (GPUs). The empirical results indicate that the parameters of the models are reliably estimated and consistent with values reported in previous work. In particular, both the vola...

This article explores the creation of the system for the conservation of architectural heritage in Northern Ireland, evidencing the struggle for convergence within the UK before 1972. The agency of networked individuals, close state–civil society interrelationships and the innovative actions of conservationist groups in response to legislative and practice inadequacies in the 1960s are discussed. In particular, a series of ‘pre-statutory lists’ are introduced, highlighting the burgeoning interest in industrial archaeology and Victorian architecture in Belfast and the prompt provided to their creation by redevelopment. The efforts of conservationists were eventually successful after the collapse of Devolution in the early 1970s.

On 9 August 1945, the United States dropped an atomic bomb on Nagasaki. Of the dead, approximately 8500 were Catholic, representing sixty to seventy-five percent of their own community and over ten percent of the total. This thesis analyses the memories and narratives of surviving members of the Catholic community in Nagasaki through the lens of Johann Metz’s theology of ‘dangerous memory’. For the Catholic survivors, memories of the bombing destruction are linked to community narratives about religious persecution and marginalisation in earlier times. The survivors speak about ongoing tests of faith, but also their own resilience and survival.

Background: Oestrogen receptor positive (ER+) breast cancer patients can acquire endocrine resistance and 10-20% tumours have lost ER at relapse. While growth factor pathway hyperactivity and ER promoter methylation contribute to de novo ER negativity, ER loss in acquired resistance is largely unexplored. We have recently developed 11 lines from MCF7, T47D, BT474 & MDAMB361 cells to model acquired resistance emerging with prolonged (3 year) endocrine treatment both in ER+/HER2- and ER+/HER2+ disease. Here we establish prevalence of acquired ER loss in the panel, determine any association with aggressiveness, and explore ER loss mechanisms in acquired endocrine resistance. Methods: Authenticated acquired resistant models derived from endocrine responsive lines cultured for 3 years with 10-7M tamoxifen (TamR), 10-7M fulvestrant (FasR) or oestrogen deprivation (5% charcoal-stripped foetal calf serum SFCSR) were profiled for ER & PR by PCR, immunocytochemistry and Western blotting (+/- 1-2wk antihormone withdrawal), for 2nd-line endocrine responsiveness and for migration using Boyden chamber assays vs. time-matched controls. Src kinase, EGFR, HER2, MAPK & AKT activity were examined and whether their respective inhibition using saracatinib or gefitinib (1μM), trastuzumab (100nM), U0126 or LY294002 (5μM) for 1wk restored ER. ESR1 promoter methylation was examined by bisulfite modification & MethyLight PCR. Results: Substantial ER mRNA & protein loss occurred in 7/11 long-term acquired endocrine resistant lines. This was irreversible by antihormone withdrawal and paralleled by complete PR loss and endocrine growth-insensitivity. While seen in all fulvestrant resistant lines, ER loss was less frequent with tamoxifen (in MCF7TamR & MDATamR) and only seen in oestrogen deprived resistant T47DSFCSR cells. Increased migration accompanied acquired ER loss in ER+/HER2- derived MCF7TamR, MCF7FasR & T47DSFCSR cells and was saracatinib-sensitive. Src and further growth factor pathway activity increased in several acquired resistant models, and ER loss associated with increased EGFR/HER2 in the MCF7- & MDA-derived cells and with increased MAPK activity in all lines. Weak ER recovery was seen in antioestrogen resistant models treated with saracatinib (MDATamR, MCF7FasR), gefitinib (MDATamR, BT474FasR, MCF7FasR/TamR) or trastuzumab (MCF7TamR). ESR1 DNA methylation was only prominent in MDATamR and MCF7TamR cells. No inhibitor restored ER in the T47D-derived cells, including T47DSFCSR which also lacked ESR1 methylation. Conclusions: Although ER loss is very prominent in this acquired resistant cell panel, it demonstrates there is capacity of prolonged antihormones, chiefly antioestrogens, to promote receptor loss independent of initial HER2 status. Acquired ER loss clinically would be expected to confer endocrine insensitivity and poorer prognosis given the panel findings. Where ER loss emerged with antioestrogens there was some mechanistic-overlap with de novo ER negativity, including ER promoter methylation for acquired tamoxifen resistance. Our future studies will use the panel to address if targeting these mechanisms can be optimized for ER recovery or if further mechanisms also drive ER loss in acquired resistance, notably for prolonged oestrogen deprivation. Citation Format: Julia M Gee, Mei Yee Meng, Richard A McClelland, Huw J Mottram, Susan R Kyme, Pauline Finlay, Lindy Goddard, Carol M Dutkowski, Denise Barrow, Walther Parson, Heidi Fiegl. A new cell panel to study oestrogen receptor loss in acquired endocrine resistant breast cancer [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P3-05-19.

The multiple socio-economic benefits ascribed to cycling are increasingly recognised by politicians and policymakers on the island of Ireland. Although a network of greenways and long-distance cycle routes are under construction in many urban and rural areas, harnessing the numerous opportunities in the Irish border region remains under-developed. To progress the development of cycling infrastructure in the border region, it is asserted that local and national policy frameworks require strengthening and integration; that strategic coordination and master-planning processes should be initiated; and, innovative funding mechanisms are needed to enable on-the-ground delivery. Improved cross-border connectivity is considered a critical component in realising the promised ‘cycling revolution’ on the island.