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1. Epidemiology of gastroenteropancreatic neuroendocrine neoplasms: a review and protocol presentation for bridging tumor registry data with the Italian association for neuroendocrine tumors (Itanet) national database

Author

Panzuto, Francesco, Partelli, Stefano, Campana, Davide, de Braud, Filippo, Spada, Francesca, Cives, Mauro, Tafuto, Salvatore, Bertuzzi, Alexia, Gelsomino, Fabio, Bergamo, Francesca, Marcucci, Stefano, Mastrangelo, Laura, Massironi, Sara, Appetecchia, Marialuisa, Filice, Angelina, Badalamenti, Giuseppe, Bartolomei, Mirco, Amoroso, Vito, Landoni, Luca, Rodriquenz, Maria Grazia, Valente, Monica, Colao, Annamaria, Isidori, Andrea, Fanciulli, Giuseppe, Bollina, Roberto, Ciola, Michele, Butturini, Giovanni, Marconcini, Riccardo, Arvat, Emanuela, Cinieri, Saverio, Berardi, Rossana, Baldari, Sergio, Riccardi, Ferdinando, Spoto, Chiara, Giuffrida, Dario, Gattuso, Domenico, Ferone, Diego, Rinzivillo, Maria, Bertani, Emilio, Versari, Annibale, Zerbi, Alessandro, Lamberti, Giuseppe, Lauricella, Eleonora, Pusceddu, Sara, Fazio, Nicola, Dell’Unto, Elisabetta, Marini, Marco, and Falconi, Massimo

Published
2024
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3. The Molecular Tumor Board of the Regina Elena National Cancer Institute: from accrual to treatment in real-world

Author

Giacomini, Patrizio, Valenti, Fabio, Allegretti, Matteo, Pallocca, Matteo, De Nicola, Francesca, Ciuffreda, Ludovica, Fanciulli, Maurizio, Scalera, Stefano, Buglioni, Simonetta, Melucci, Elisa, Casini, Beatrice, Carosi, Mariantonia, Pescarmona, Edoardo, Giordani, Elena, Sperati, Francesca, Jannitti, Nicoletta, Betti, Martina, Maugeri-Saccà, Marcello, Cecere, Fabiana Letizia, Villani, Veronica, Pace, Andrea, Appetecchia, Marialuisa, Vici, Patrizia, Savarese, Antonella, Krasniqi, Eriseld, Ferraresi, Virginia, Russillo, Michelangelo, Fabi, Alessandra, Landi, Lorenza, Minuti, Gabriele, Cappuzzo, Federico, Zeuli, Massimo, and Ciliberto, Gennaro

Published
2023
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6. Contributors

Author

Appetecchia, Marialuisa, primary, Aragona, Cesare, additional, Barbaro, Daniele, additional, Benvenga, Salvatore, additional, Bevilacqua, Arturo, additional, Bizzarri, Mariano, additional, Cantelmi, Tonino, additional, Cavalli, Pietro, additional, Chan, Shiao-yng, additional, Copp, Andrew J., additional, D’Anna, Rosario, additional, Dewailly, Didier, additional, Di Lorenzo, Cherubino, additional, Diamanti-Kandarakis, Evanthia, additional, Dinicola, Simona, additional, Espinola, Maria Salomè Bezerra, additional, Facchinetti, Fabio, additional, Greene, Nicholas D.E., additional, Hod, Moshe, additional, Kamenov, Zdravko, additional, Laganà, Antonio Simone, additional, Monastra, Giovanni, additional, Nestler, John E., additional, Nordio, Maurizio, additional, Oliva, Mario Montanino, additional, Özay, Ali Cenk, additional, Papalou, Olga, additional, Pkhaladze, Lali, additional, Porcaro, Giuseppina, additional, Prapas, Nikos, additional, Roseff, Scott, additional, Soulage, Christophe O., additional, Stringaro, Annarita, additional, Unfer, Vittorio, additional, Vazquez-Levin, Monica, additional, Vucenik, Ivana, additional, Wdowiak, Artur, additional, and Yu, Tony Chiu Tak, additional

Published
2023
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7. Prognostic significance of laterality in lung neuroendocrine tumors

Author

La Salvia, Anna, Persano, Irene, Siciliani, Alessandra, Verrico, Monica, Bassi, Massimiliano, Modica, Roberta, Audisio, Alessandro, Zanata, Isabella, Trabalza Marinucci, Beatrice, Trevisi, Elena, Puliani, Giulia, Rinzivillo, Maria, Parlagreco, Elena, Baldelli, Roberto, Feola, Tiziana, Sesti, Franz, Razzore, Paola, Mazzilli, Rossella, Mancini, Massimiliano, Panzuto, Francesco, Volante, Marco, Giannetta, Elisa, Romero, Carmen, Appetecchia, Marialuisa, Isidori, Andrea, Venuta, Federico, Ambrosio, Maria Rosaria, Zatelli, Maria Chiara, Ibrahim, Mohsen, Colao, Annamaria, Brizzi, Maria Pia, García-Carbonero, Rocío, and Faggiano, Antongiulio

Published
2022
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8. Angiogenic factors as prognostic markers in neuroendocrine neoplasms

Author

Puliani, Giulia, Sesti, Franz, Anastasi, Emanuela, Verrico, Monica, Tarsitano, Maria Grazia, Feola, Tiziana, Campolo, Federica, Di Gioia, Cira Rosaria Tiziana, Venneri, Mary Anna, Angeloni, Antonio, Appetecchia, Marialuisa, Lenzi, Andrea, Isidori, Andrea Marcello, Faggiano, Antongiulio, and Giannetta, Elisa

Published
2022
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10. Recommendations for the Application of Sex and Gender Medicine in Preclinical, Epidemiological and Clinical Research.

Author

Cattaneo, Annamaria, Bellenghi, Maria, Ferroni, Eliana, Mangia, Cristina, Marconi, Matteo, Rizza, Paola, Borghini, Alice, Martini, Lorena, Luciani, Maria Novella, Ortona, Elena, Carè, Alessandra, and Appetecchia, Marialuisa

Subjects
GENDER, GENDER medicine, SOCIAL impact, RESEARCH protocols, CLINICAL epidemiology
Abstract

Gender medicine studies how health status and diseases differ between men and women in terms of prevention, therapeutic approach, prognosis, and psychological and social impact. Sex and gender analyses have been demonstrated to improve science, contributing to achieving real appropriateness and equity in the cure for each person. Therefore, it is fundamental to consider, both in preclinical and clinical research, the different clinical and biological features associated with sex and/or gender, where sex differences are mainly influenced by biological determinants and gender ones by socio-cultural and economic matters. This article was developed to provide knowledge and methodological tools for the development of studies/research protocols in which sex and gender should be taken into account. [ABSTRACT FROM AUTHOR]

Published
2024
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11. The Role of Inositols in Endocrine and Neuroendocrine Tumors.

Author

Mormando, Marilda, Puliani, Giulia, Bianchini, Marta, Lauretta, Rosa, and Appetecchia, Marialuisa

Subjects
NEUROENDOCRINE tumors, THYROID cancer, CANCER prevention, INOSITOL, OXIDATIVE stress
Abstract

Inositols have demonstrated a role in cancer prevention and treatment in many kinds of neoplasms. Their molecular mechanisms vary from the regulation of survival and proliferative pathways to the modulation of immunity and oxidative stress. The dysregulation of many pathways and mechanisms regulated by inositols has been demonstrated in endocrine and neuroendocrine tumors but the role of inositol supplementation in this context has not been clarified. The aim of this review is to summarize the molecular basis of the possible role of inositols in endocrine and neuroendocrine tumors, proposing it as an adjuvant therapy. [ABSTRACT FROM AUTHOR]

Published
2024
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12. d-Chiro-Inositol in Clinical Practice: A Perspective from the Experts Group on Inositol in Basic and Clinical Research (EGOI).

Author

Dinicola, Simona, Unfer, Vittorio, Soulage, Christophe O., Yap-Garcia, Maria Isidora Margarita, Bevilacqua, Arturo, Benvenga, Salvatore, Barbaro, Daniele, Wdowiak, Artur, Nordio, Maurizio, Dewailly, Didier, Appetecchia, Marialuisa, Aragona, Cesare, Espinola, Maria Salomè Bezerra, Bizzarri, Mariano, Cavalli, Pietro, Colao, Annamaria, D'Anna, Rosario, Vazquez-Levin, Mónica Hebe, Hernàndez Marin, Imelda, and Kamenov, Zdravko

Subjects
WHITE adipose tissue, BROWN adipose tissue, BONE health, INSULIN resistance, METABOLIC disorders
Abstract

Background:d-Chiro-inositol is a natural molecule that, in association with its well-studied isomer myo-inositol, may play a role in treating various metabolic and gynecological disorders. Objectives: This perspective seeks to explore the mechanisms and functions of d-chiro-inositol, laying the foundations to discuss its use in clinical practice, across dysmetabolism, obesity, and hormonal dysregulation. Methods: A narrative review of all the relevant papers known to the authors was conducted. Outcome:d-Chiro-inositol acts through a variety of mechanisms, acting as an insulin sensitizer, inhibiting the transcription of aromatase, in addition to modulating white adipose tissue/brown adipose tissue transdifferentiation. These different modes of action have potential applications in a variety of therapeutic fields, including PCOS, dysmetabolism, obesity, hypoestrogenic/hyperandrogenic disorders, and bone health. Conclusions:d-Chiro-inositol mode of action has been studied in detail in recent years, resulting in a clear differentiation between d-chiro-inositol and its isomer myo-inositol. The insulin-sensitizing activities of d-chiro-inositol are well understood; however, its potential applications in other fields, in particular obesity and hyperestrogenic/hypoandrogenic disorders in men and women, represent promising avenues of research that require further clinical study. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Breakthroughs in the Use of Inositols for Assisted Reproductive Treatment (ART)

Author

Facchinetti, Fabio, Unfer, Vittorio, Appetecchia, Marialuisa, Aragona, Cesare, Bertelli, Matteo, Bevilacqua, Arturo, Espinola, Maria Salome Bezerra, Bizzarri, Mariano, Cavalli, Pietro, Copp, Andrew, D’Anna, Rosario, Dewailly, Didier, Greene, Nicholas, Marín, Imelda Hernández, Kamenov, Zdravko A., Kandaraki, Eleni, Diamanti-Kandarakis, Evanthia, Laganà, Antonio Simone, Monastra, Giovanni, Oliva, Mario Montanino, Nestler, John E., Ozay, Ali Cenk, Papalou, Olga, Pkhaladze, Lali, Porcaro, Giusy, Prapas, Nikos, Soulage, Christophe O., Stringaro, Annarita, Vazquez-Levin, Mónica, and Wdowiak, Artur

Published
2020
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14. Ultrasound and Clinical Parameters in Patients with Hashimoto’s Thyroiditis Related to Dermatological Diseases: A Cross-Sectional Study

Author

Desiderio, Flora, primary, Puliani, Giulia, additional, Mariano, Maria, additional, Guerrisi, Antonino, additional, Elia, Fulvia, additional, Solivetti, Francesco Maria, additional, Barnabei, Agnese, additional, Sperati, Francesca, additional, Morrone, Aldo, additional, and Appetecchia, Marialuisa, additional

Published
2024
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15. NRF2 activation in BON‑1 neuroendocrine cancer cells reduces the cytotoxic effects of a novel Ruthenium(II)‑curcumin compound: A pilot study

Author

Garufi, Alessia, primary, Pettinari, Riccardo, additional, Monteonofrio, Laura, additional, Puliani, Giulia, additional, Virdia, Ilaria, additional, Appetecchia, Marialuisa, additional, Marchetti, Fabio, additional, Cirone, Mara, additional, Soddu, Silvia, additional, and D'Orazi, Gabriella, additional

Published
2024
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17. Management of Gastric Neuroendocrine Tumors

Author

Carlini, Massimo, Apa, Daniela, Spoletini, Domenico, Grieco, Michele, Appetecchia, Marialuisa, Rota, Francesca, Palazzo, Salvatore, Turano, Salvatore, Carlini, Massimo, editor, Montorsi, Marco, and Santoro, Eugenio

Published
2018
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22. Syndrome of Inappropriate Antidiuresis and Diabetes Insipidus as Two Sides of the Same Coin in Hypothalamic Lymphoma: A Case Report

Author

Appetecchia Marialuisa, Mormando Marilda, Lauretta Rosa, Telera Stefano, Bianchini Marta, Chiefari Alfonsina, Natalino Fiammetta, and Puliani Giulia

Subjects
Endocrinology, Diabetes and Metabolism, Immunology and Allergy
Abstract

Background: Hypothalamic-pituitary region lymphoma is rare and diabetes insipidus (DI) represents one of the most common endocrine manifestations. We report the first case of hypothalamic lymphoma associated with both the syndrome of inappropriate antidiuresis (SIAD) and DI. Case report: A 64-year-old woman with a history of stage IV large B-cell non-Hodgkin lymphoma, underwent atypical right lung resection for pulmonary nodules. A few days after surgery, the patient presented severe normovolemic hyponatremia and serum hypo-osmolarity, therefore, we suspected a paraneoplastic syndrome (SIAD) related to the lung neoplasm, histologically diagnosed as typical carcinoid. The brain magnetic resonance imaging (MRI) showed a 9 mm lesion in the hypothalamic region that significantly increased one month later with the onset of neurological symptoms. A trans-sphenoidal biopsy showed localization of the large B-cell lymphoma. After surgery, the patient presented with polyuria and polydipsia, so desmopressin therapy was started. In the following days, serum osmolarity and sodium fluctuated between normal and low values, then DI was excluded, and SIAD became more likely. Desmopressin therapy was discontinued and hyponatremia was treated with sodium infusion. Hypothalamic lymphoma was treated with chemotherapy and radiotherapy with substantial shrinkage. The hyponatremia persisted during anticancer treatments and improved only after radiotherapy, confirming paraneoplastic SIAD. Conclusion: Lymphomas of the hypothalamic region can cause electrolyte imbalance for various causes. The differential diagnosis between SIAD, DI and impaired thirst centers may not be straightforward and they must be evaluated step by step in all different stages of the disease.

Published
2023
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23. Prognosis of patients with differentiated thyroid carcinomas having a preoperative cytological report of indeterminate at low or high risk. A multicenter study

Author

Trimboli, Pierpaolo, Palermo, Andrea, Deandrea, Maurilio, Piccardo, Arnoldo, Campennì, Alfredo, Valabrega, Stefano, Grani, Giorgio, Santolamazza, Giuliano, Bottoni, Gianluca, Barnabei, Agnese, Ramundo, Valeria, Lauretta, Rosa, Monte, Lavinia, Ferrarazzo, Giulia, Paone, Gaetano, Crosetto, Cecilia, Ruggeri, Rosaria Maddalena, Baldari, Sergio, Chiefari, Alfonsina, Vottari, Sebastiano, Giarnieri, Enrico, Perrella, Eleonora, Limone, Paolo, Durante, Cosimo, Giovanella, Luca, Appetecchia, Marialuisa, and Crescenzi, Anna

Published
2019
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24. Neurological adverse events of mitotane in adrenocortical carcinoma: results of a pilot study

Author

Mormando, Marilda, primary, Galiè, Edvina, additional, Bianchini, Marta, additional, Lauretta, Rosa, additional, Puliani, Giulia, additional, Tanzilli, Antonio, additional, Anceschi, Umberto, additional, Simone, Giuseppe, additional, Petreri, Gianluca, additional, Graziano, Giuliana, additional, Pace, Andrea, additional, and Appetecchia, Marialuisa, additional

Published
2023
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25. Immune profile in acromegalic patients and the impact of the current medical treatment. Resultsfrom the PROMISE study

Author

Feola, Tiziana, primary, De, Alcubierre Dario, additional, Sada, Valentina, additional, Puliani, Giulia, additional, Sciarra, Francesca, additional, Cozzolino, Alessia, additional, Appetecchia, Marialuisa, additional, Sbardella, Emilia, additional, Jaffrain-Rea, Marie-Lise, additional, Anna, Venneri Mary, additional, and Isidori, Andrea, additional

Published
2023
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26. Gender related differences in patients with carcinoid syndrome: new insights from a multicenter retrospective study

Author

Grazia, Tarsitano Maria, primary, Altieri, Barbara, additional, Grossrubatscher, Erika, additional, Minotta, Roberto, additional, Zamponi, Virginia, additional, Albertelli, Manuela, additional, Appetecchia, Marialuisa, additional, Pia, Brizzi Maria, additional, Vittoria, Davi Maria, additional, Fanciulli, Giuseppe, additional, Giannetta, Elisa, additional, Guarnotta, Valentina, additional, La, Salvia Anna, additional, Lania, Andrea, additional, Lavezzi, Elisabetta, additional, Malandrino, Pasqualino, additional, Mazzilli, Rossella, additional, Modica, Roberta, additional, Pia, Anna, additional, Prinzi, Natalie, additional, Pusceddu, Sara, additional, Razzore, Paula, additional, Zanata, Isabella, additional, Chiara, Zatelli Maria, additional, Isidori, Andrea, additional, Maria, Colao Anna, additional, Faggiano, Antongiulio, additional, and Maddalena, Ruggeri Rosaria, additional

Published
2023
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27. Prolonged exposure to target mitotane concentrations is associated with better recurrence-free survival in patients with adrenocortical carcinoma on adjuvant treatment

Author

Puglisi, Soraya, primary, Calabrese, Anna, additional, Basile, Vittoria, additional, Kimpel, Otilia, additional, Altieri, Barbara, additional, Angelousi, Anna, additional, Kaltsas, Gregory, additional, Ambroziak, Urszula, additional, Appetecchia, Marialuisa, additional, Arosio, Maura, additional, Berruti, Alfredo, additional, Cosentini, Deborah, additional, Canu, Letizia, additional, Ceccato, Filippo, additional, Dalmazi, Guido Di, additional, Bouys, Lucas, additional, Libe, Rossella, additional, Papierska, Lucyna, additional, Pittaway, James, additional, Kienitz, Tina, additional, Quinkler, Marcus, additional, Elhassan, Yasir, additional, Ronchi, Cristina, additional, Saiegh, Leonard, additional, Stigliano, Antonio, additional, Dusek, Tina, additional, Kastelan, Darko, additional, Fassnacht, Martin, additional, and Terzolo, Massimo, additional

Published
2023
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28. The Therapeutic Intensity Score as Predictor of Clinical Outcomes after Total and Partial Adrenalectomy for Unilateral Primary Aldosteronism: Results of a Multicentric Series

Author

Anceschi, Umberto, primary, Mormando, Marilda, additional, Flammia, Rocco Simone, additional, Fiori, Cristian, additional, Zappalà, Orazio, additional, De Concilio, Bernardino, additional, Brassetti, Aldo, additional, Carrara, Alessandro, additional, Ferriero, Maria Consiglia, additional, Tuderti, Gabriele, additional, Misuraca, Leonardo, additional, Prata, Francesco, additional, Tufano, Antonio, additional, Bove, Alfredo Maria, additional, Mastroianni, Riccardo, additional, Appetecchia, Marialuisa, additional, Tirone, Giuseppe, additional, Porpiglia, Francesco, additional, Celia, Antonio, additional, and Simone, Giuseppe, additional

Published
2023
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30. Whole exome sequencing identifies a germline MET mutation in two siblings with hereditary wild‐type RET medullary thyroid cancer

Author

Sponziello, Marialuisa, Benvenuti, Silvia, Gentile, Alessandra, Pecce, Valeria, Rosignolo, Francesca, Virzì, Anna Rita, Milan, Melissa, Comoglio, Paolo M., Londin, Eric, Fortina, Paolo, Barnabei, Agnese, Appetecchia, Marialuisa, Marandino, Ferdinando, Russo, Diego, Filetti, Sebastiano, Durante, Cosimo, and Verrienti, Antonella

Published
2018
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31. Radiofrequency ablation for thyroid nodules: which indications? The first Italian opinion statement

Author

Garberoglio, Roberto, Aliberti, Camillo, Appetecchia, Marialuisa, Attard, Marco, Boccuzzi, Giuseppe, Boraso, Flavio, Borretta, Giorgio, Caruso, Giuseppe, Deandrea, Maurilio, Freddi, Milena, Gallone, Gabriella, Gandini, Giovanni, Gasparri, Guido, Gazzera, Carlo, Ghigo, Ezio, Grosso, Maurizio, Limone, Paolo, Maccario, Mauro, Mansi, Luigi, Mormile, Alberto, Nasi, Pier Giorgio, Orlandi, Fabio, Pacchioni, Donatella, Pacella, Claudio Maurizio, Palestini, Nicola, Papini, Enrico, Pelizzo, Maria Rosa, Piotto, Andrea, Rago, Teresa, Riganti, Fabrizio, Rosato, Lodovico, Rossetto, Ruth, Scarmozzino, Antonio, Spiezia, Stefano, Testori, Ornella, Valcavi, Roberto, Veltri, Andrea, Vitti, Paolo, and Zingrillo, Matteo

Published
2015
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33. PD04-05 CLINICAL CURE VS A NOVEL TRIFECTA SYSTEM FOR EVALUATING LONG-TERM OUTCOMES OF MINIMALLY-INVASIVE PARTIAL OR TOTAL ADRENALECTOMY FOR UNILATERAL PRIMARY ALDOSTERONISM: RESULTS OF A MULTICENTRIC SERIES

Author

Anceschi, Umberto, primary, Mastroianni, Riccardo, additional, Tuderti, Gabriele, additional, Bove, Alfredo Maria, additional, Brassetti, Aldo, additional, Ferriero, Mariaconsiglia, additional, Mormando, Marilda, additional, Carrara, Alessandro, additional, De Concilio, Bernardino, additional, Misuraca, Leonardo, additional, Zappalà, Orazio, additional, Fiori, Cristian, additional, Appetecchia, Marialuisa, additional, Celia, Antonio, additional, Porpiglia, Francesco, additional, Tirone, Giuseppe, additional, Gallucci, Michele, additional, and Simone, Giuseppe, additional

Published
2022
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34. New Insights in PRRT: Lessons From 2021

Author

Puliani, Giulia, primary, Chiefari, Alfonsina, additional, Mormando, Marilda, additional, Bianchini, Marta, additional, Lauretta, Rosa, additional, and Appetecchia, Marialuisa, additional

Published
2022
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35. Surgical Quality, Antihypertensive Therapy, and Electrolyte Balance: A Novel Trifecta to Assess Long-Term Outcomes of Adrenal Surgery for Unilateral Primary Aldosteronism

Author

Anceschi, Umberto, primary, Mormando, Marilda, additional, Fiori, Cristian, additional, Zappalà, Orazio, additional, De Concilio, Bernardino, additional, Brassetti, Aldo, additional, Carrara, Alessandro, additional, Ferriero, Maria Consiglia, additional, Tuderti, Gabriele, additional, Misuraca, Leonardo, additional, Bove, Alfredo Maria, additional, Mastroianni, Riccardo, additional, Chiefari, Alfonsina, additional, Appetecchia, Marialuisa, additional, Tirone, Giuseppe, additional, Porpiglia, Francesco, additional, Celia, Antonio, additional, Gallucci, Michele, additional, and Simone, Giuseppe, additional

Published
2022
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37. New Prognostic Frontiers for Lung Neuroendocrine Tumors

Author

Salvia, Anna La, primary, Persano, Irene, additional, Siciliani, Alessandra, additional, Verrico, Monica, additional, Bassi, Massimiliano, additional, Modica, Roberta, additional, Audisio, Alessandro, additional, Zanata, Isabella, additional, Marinucci, Beatrice Trabalza, additional, Trevisi, Elena, additional, Puliani, Giulia, additional, Rinzivillo, Maria, additional, Parlagreco, Elena, additional, Baldelli, Roberto, additional, Feola, Tiziana, additional, Sesti, Franz, additional, Razzore, Paola, additional, Mazzilli, Rossella, additional, Mancini, Massimiliano, additional, Panzuto, Francesco, additional, Volante, Marco, additional, Giannetta, Elisa, additional, Romero, Carmen, additional, Appetecchia, Marialuisa, additional, Isidori, Andrea, additional, Venuta, Federico, additional, Ambrosio, Maria Rosaria, additional, Zatelli, Maria Chiara, additional, Ibrahim, Mohsen, additional, Colao, Annamaria, additional, Brizzi, Maria Pia, additional, Carbonero, Rocio Garcia, additional, and Faggiano, Antongiulio, additional

Published
2022
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38. A Multicenter Epidemiological Study on Second Malignancy in Non-Syndromic Pheochromocytoma/Paraganglioma Patients in Italy

Author

Canu, Letizia, primary, Puglisi, Soraya, additional, Berchialla, Paola, additional, De Filpo, Giuseppina, additional, Brignardello, Francesca, additional, Schiavi, Francesca, additional, Ferrara, Alfonso Massimiliano, additional, Zovato, Stefania, additional, Luconi, Michaela, additional, Pia, Anna, additional, Appetecchia, Marialuisa, additional, Arvat, Emanuela, additional, Letizia, Claudio, additional, Maccario, Mauro, additional, Parasiliti-Caprino, Mirko, additional, Altieri, Barbara, additional, Faggiano, Antongiulio, additional, Modica, Roberta, additional, Morelli, Valentina, additional, Arosio, Maura, additional, Verga, Uberta, additional, Pellegrino, Micaela, additional, Petramala, Luigi, additional, Concistrè, Antonio, additional, Razzore, Paola, additional, Ercolino, Tonino, additional, Rapizzi, Elena, additional, Maggi, Mario, additional, Stigliano, Antonio, additional, Burrello, Jacopo, additional, Terzolo, Massimo, additional, Opocher, Giuseppe, additional, Mannelli, Massimo, additional, and Reimondo, Giuseppe, additional

Published
2021
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40. Angiogenic factors as prognostic markers in neuroendocrine neoplasms

Author

Puliani, Giulia, Sesti, Franz, Anastasi, Emanuela, Verrico, Monica, Tarsitano, Maria Grazia, Feola, Tiziana, Campolo, Federica, Di Gioia, Cira Rosaria Tiziana, Venneri, Mary Anna, Angeloni, Antonio, Appetecchia, Marialuisa, Lenzi, Andrea, Isidori, Andrea M., Faggiano, Antongiulio, Giannetta, Elisa, Nettare, Unit, Severi, Carola, Cantisani, Vito, and Maccioni, Francesca

Subjects
neuroendocrine neoplasm, Endocrinology, Diabetes and Metabolism, angiopoietin, Prognosis, angiogenesis, neuroendocrine tumor, PROK2, prognostic marker, Pancreatic Neoplasms, Neuroendocrine Tumors, Endocrinology, Stomach Neoplasms, Intestinal Neoplasms, Humans, Angiogenesis Inducing Agents
Abstract

Angiogenic markers in neuroendocrine neoplasms (NENs) have recently received increasing attention, but their clinical role remains unclear. The aim of this study was to evaluate the role of angiogenic markers in NEN aggressiveness and prognosis.We performed a prospective observational study including 46 consecutive patients with proven NENs of pulmonary (45.65%) and gastro-entero-pancreatic (GEP) (54.35%) origin and 29 healthy controls. Circulating pro-angiogenic factors were measured by ELISA assay. ANG2 tissue expression was evaluated in a subgroup of ten patients by immunohistochemistry.The study demonstrated a significantly higher level of ANG2, ANG1, sTIE2, and PROK2 in patients affected by NENs compared to controls. In the NENs' group we measured that: (i) ANG2 levels were higher in poorly vs well-differentiated NENs: 4.85 (2.75-7.42) vs 3.16 (1.66-6.36) ng/ml, p = 0.046 and in tumor stage 3-4 compared to stage 1-2: 4.24 (2.66-8.72) vs 2.73 (1.53-5.70), p = 0.044; (ii) ANG2 and PROK2 were significantly higher in patents with progressive disease compared to stable disease: ANG2 = 6.26 (3.98-10.99) vs 2.73 (1.65-4.36) pg/ml, p = 0.001; PROK2 = 29.19 (28.42-32.25) vs 28.37 (28.14-28.91) pg/ml, p = 0.035. Immunohistochemistry confirmed ANG2 expression in tumor specimens.We documented higher levels of angiogenic markers in NENs, with an association between ANG2 serum levels and NENs morphology and staging. In both GEP and lung NENs, ANG2 and PROK2 are higher in case of tumor progression, suggesting a potential role as prognostic markers in NENs patients.

Published
2021

41. Clinical cure vs a novel trifecta system for evaluating long-term outcomes of minimally-invasive partial or total adrenalectomy for unilateral primary aldosteronism: results of a multicentric series.

Author

Anceschi, Umberto, Tufano, Antonio, Flammia, Rocco Simone, Mormando, Marilda, Fiori, Cristian, Zappalà, Orazio, De Concilio, Bernardino, Carrara, Alessandro, Consiglia, Ferriero Maria, Tuderti, Gabriele, Brassetti, Aldo, Misuraca, Leonardo, Bove, Alfredo Maria, Mastroianni, Riccardo, Appetecchia, Marialuisa, Tirone, Giuseppe, Porpiglia, Francesco, Celia, Antonio, Gallucci, Michele, and Simone, Giuseppe

Subjects
HYPERALDOSTERONISM, ADRENALECTOMY, HYPERTENSION, REGRESSION analysis, PERIOPERATIVE care
Abstract

Introduction. Several predictive scores to evaluate outcomes of adrenal surgery for unilateral primary aldosteronism (UPA), have been conceived. We compared a novel trifecta that summarizes outcomes of adrenal surgery for UPA with the clinical cure proposed by Vorselaars. Material and methods. Between March 2011 and January 2022, a multi-institutional dataset was queried for UPA. Baseline, perioperative and functional data were collected. Clinical and biochemical complete and partial success rates according to Primary Aldosteronism Surgical Outcome (PASO) criteria were assessed for the overall cohort. Clinical cure was defined either as normotension without antihypertensive medications or normotension with lower or equal use of antihypertensive medications. Trifecta was defined as the coexistence of =50% antihypertensive therapeutic intensity score (TIS) reduction (ΔTIS), no electrolyte impairment at 3-months and no Clavien-Dindo (2-5) complications. Cox regression analyses were used to identify predictors of long-term clinical and biochemical success. For all analyses, a two-sided p <0.05 was considered significant. Results Baseline, perioperative and functional outcomes were analyzed. Out of 90 patients, at a median follow-up of 42 months (IQR 27-54) a complete and partial clinical success was observed in 60% and 17.7% of cases while a complete and partial biochemical success was achieved in 83.3% and 12.3% of cases, respectively. Overall trifecta and clinical cure rates were 21.1% and 58.9%, respectively. On multivariable Cox regression analysis, trifecta achievement (HR 2.87; 95% CI 1.45-5.58; p = 0.02) was the only independent predictor of complete clinical success at long-term follow-up. Conclusions Despite its complex estimation and more restrictive criteria, trifecta but not clinical cure allows to independently predict composite PASO endpoints on the long run. [ABSTRACT FROM AUTHOR]

Published
2022
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42. Inositols: From Established Knowledge to Novel Approaches

Author

Dinicola, Simona, primary, Unfer, Vittorio, additional, Facchinetti, Fabio, additional, Soulage, Christophe O., additional, Greene, Nicholas D., additional, Bizzarri, Mariano, additional, Laganà, Antonio Simone, additional, Chan, Shiao-Yng, additional, Bevilacqua, Arturo, additional, Pkhaladze, Lali, additional, Benvenga, Salvatore, additional, Stringaro, Annarita, additional, Barbaro, Daniele, additional, Appetecchia, Marialuisa, additional, Aragona, Cesare, additional, Bezerra Espinola, Maria Salomè, additional, Cantelmi, Tonino, additional, Cavalli, Pietro, additional, Chiu, Tony T., additional, Copp, Andrew J., additional, D’Anna, Rosario, additional, Dewailly, Didier, additional, Di Lorenzo, Cherubino, additional, Diamanti-Kandarakis, Evanthia, additional, Hernández Marín, Imelda, additional, Hod, Moshe, additional, Kamenov, Zdravko, additional, Kandaraki, Eleni, additional, Monastra, Giovanni, additional, Montanino Oliva, Mario, additional, Nestler, John E., additional, Nordio, Maurizio, additional, Ozay, Ali C., additional, Papalou, Olga, additional, Porcaro, Giuseppina, additional, Prapas, Nikos, additional, Roseff, Scott, additional, Vazquez-Levin, Monica, additional, Vucenik, Ivana, additional, and Wdowiak, Artur, additional

Published
2021
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48. Patient Age Is an Independent Risk Factor of Relapse of Differentiated Thyroid Carcinoma and Improves the Performance of the American Thyroid Association Stratification System

Author

Trimboli, Pierpaolo, primary, Piccardo, Arnoldo, additional, Signore, Alberto, additional, Valabrega, Stefano, additional, Barnabei, Agnese, additional, Santolamazza, Giuliano, additional, Di Paolo, Arianna, additional, Stati, Valeria, additional, Chiefari, Alfonsina, additional, Vottari, Sebastiano, additional, Simmaco, Maurizio, additional, Ferrarazzo, Giulia, additional, Ceriani, Luca, additional, Appetecchia, Marialuisa, additional, and Giovanella, Luca, additional

Published
2020
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49. Experts’ opinion on inositols in treating polycystic ovary syndrome and non-insulin dependent diabetes mellitus: a further help for human reproduction and beyond

Author

Facchinetti, Fabio, primary, Appetecchia, Marialuisa, additional, Aragona, Cesare, additional, Bevilacqua, Arturo, additional, Bezerra Espinola, Maria Salome, additional, Bizzarri, Mariano, additional, D’Anna, Rosario, additional, Dewailly, Didier, additional, Diamanti-Kandarakis, Evanthia, additional, Hernández Marín, Imelda, additional, Kamenov, Zdravko A., additional, Kandaraki, Eleni, additional, Laganà, Antonio Simone, additional, Monastra, Giovanni, additional, Montanino Oliva, Mario, additional, Nestler, John E., additional, Orio, Francesco, additional, Ozay, Ali Cenk, additional, Papalou, Olga, additional, Pkhaladze, Lali, additional, Porcaro, Giusy, additional, Prapas, Nikos, additional, Soulage, Christophe O., additional, Stringaro, Annarita, additional, Wdowiak, Artur, additional, and Unfer, Vittorio, additional

Published
2020
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50. Additional file 1: of Erratum to: Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer

Author

Prodosmo, Andrea, Buffone, Amelia, Mattioni, Manlio, Barnabei, Agnese, Persichetti, Agnese, Leo, Aurora De, Appetecchia, Marialuisa, Nicolussi, Arianna, Coppa, Anna, Sciacchitano, Salvatore, Giordano, Carolina, Pinnarò, Paola, Sanguineti, Giuseppe, Strigari, Lidia, Alessandrini, Gabriele, Facciolo, Francesco, Cosimelli, Maurizio, Grazi, Gian, Corrado, Giacomo, Vizza, Enrico, Giannini, Giuseppe, and Soddu, Silvia

Abstract

Characteristics of ATM variants. (DOCX 16 kb)

Published
2019
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