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13. Effects of bcrp and p-gp modulators on the penetration of aflatoxin b1 into the mouse brain

Author

TRAS B, CETIN G, UNEY K, DIK B, CORUM O, and ATALAY S

Subjects
aflatoxin b1, brain, drug transporter proteins, modulation, mice, Veterinary medicine, SF600-1100
Abstract

This study was conducted to determine whether the plasma and brain concentrations of AFB1 are affected by the modulation of P-gp and BCRP using zosuquidar (ZQR) and prazosin (PRZ), respectively. In this study, a total of 40 healthy adult male BALB/c mice (32±3.7 g) were used. The animals were randomly divided into 5 groups, with 8 animals per group. Group 1 was used for method validation. Group 2 (AF) received intraperitoneal AFB1 at a dose of 20 mg/kg of body weight. Groups 3 (AF+PRZ), 4 (AF+ZQR), and 5 (AF+PRZ+ZQR) received 20 mg/kg of AFB1 intraperitoneally 30 min after the intraperitoneal administration of prazosin (0.3 mg/kg), zosuquidar (25 mg/kg), and prazosin+zosuquidar (0.3 mg/kg prazosin + 25 mg/kg zosuquidar), respectively. Six hours after the administration of AFB1, blood and brain samples were collected from the animals in Groups 2 to 5. AFB1 concentrations were determined using an HPLC system with fluorescence detection. Individual and simultaneous administration of prazosin and zosuquidar significantly reduced the brain concentrations of AFB1 in comparison to a single administration of AFB1 (P

Published
2017
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19. Serum drug levels and anti-drug antibodies in the context of dose tapering by interval prolongation of adalimumab, etanercept and ustekinumab in psoriasis patients: results of the CONDOR trial

Author

Atalay, S., Berends, S.E., Groenewoud, H., Mathot, R.A.A., Njoo, D.M., Mommers, J.M., Ossenkoppele, P.M., Koetsier, M.I., Berends, Matthijs S., Vries, Annick de, Kerkhof, P.C.M. van de, Broeder, A.A. den, Jong, E.M.G.J. de, Reek, J.M.P.A. van den, Atalay, S., Berends, S.E., Groenewoud, H., Mathot, R.A.A., Njoo, D.M., Mommers, J.M., Ossenkoppele, P.M., Koetsier, M.I., Berends, Matthijs S., Vries, Annick de, Kerkhof, P.C.M. van de, Broeder, A.A. den, Jong, E.M.G.J. de, and Reek, J.M.P.A. van den

Abstract

Contains fulltext : 282879.pdf (Publisher’s version ) (Open Access), BACKGROUND: Biologics for psoriasis are registered in standard dosages. In patients with low disease activity, reduction of the dose by interval prolongation can prevent overtreatment, and lower risks and costs. However, fear for increased anti-drug antibody (ADA) formation due to interval prolongation of biologics is an important barrier. OBJECTIVE: To investigate the course of serum drug concentrations, ADA levels, and predictors for successful dose reduction of adalimumab, ustekinumab, and etanercept for psoriasis. METHODS: Patients were randomized to dose reduction (DR) or usual care (UC) and followed for one year. The course and extent of detectable ADA levels were expressed as proportions/relative risks for DR vs. UC. Association of baseline characteristics with successful tapering was investigated with log-binomial regression analysis. RESULTS: In total, 118 patients were included. In adalimumab-treated patients, no significant difference in the proportion of patients with relevant ADA levels in DR vs. UC was seen. For ustekinumab, relevant ADA development was absent in both groups. Baseline trough levels were not predictive for successful DR. CONCLUSIONS: Immunogenicity may not increase by interval prolongation in psoriasis patients with low disease activity. This pilot provides important and reassuring insight into the pharmacological changes after dose tapering of adalimumab, etanercept, and ustekinumab.

Published
2022

21. Two-year follow-up of a dose reduction strategy trial of biologics adalimumab, etanercept, and ustekinumab in psoriasis patients in daily practice

Author

Atalay, S., Reek, J.M.P.A. van den, Groenewoud, J.M.M., Kerkhof, P.C.M. van de, Kievit, W., Jong, E.M.G.J. de, Atalay, S., Reek, J.M.P.A. van den, Groenewoud, J.M.M., Kerkhof, P.C.M. van de, Kievit, W., and Jong, E.M.G.J. de

Abstract

Contains fulltext : 251762.pdf (Publisher’s version ) (Open Access), BACKGROUND/OBJECTIVES: Tightly-controlled dose reduction was possible during 1 year in psoriasis patients on adalimumab, etanercept or ustekinumab with low disease activity (CONDOR trial). Extended observation is needed to ensure long-term effectiveness and safety of the strategy. With prolonged follow-up, we investigated the clinical effects and safety of the strategy, the proportion of patients with successful dose reduction, and assessed if patients with a disease flare regained remission. METHODS: Two-year follow up of a subgroup of patients previously included in a randomized pragmatic study comparing usual care (UC) with stepwise dose reduction (DR). Effectiveness (Psoriasis Area and Severity Index, PASI), Dermatology Life Quality Index (DLQI), adverse events, proportion of patients with successful DR and proportion of persistent disease flares were analyzed. RESULTS: DR leads temporarily to a slightly increased PASI groupwise, but on the long-term patients regained low PASI. DLQI scores remained stable during follow-up. No serious adverse events due to DR were reported. Forty-one percent of patients remained on a low dose up to 2 years. The number of persistent flares was low in DR and UC. CONCLUSIONS: The proposed dose reduction strategy is effective for a significant part of patients and remains safe up to 2 years of follow-up.

Published
2022

22. Frequency and predictors of a high clinical response in patients with psoriasis on biological therapy in daily practice: results from the prospective, multicenter BioCAPTURE cohort

Author

Zweegers, J., Roosenboom, B., van de Kerkhof, P.C.M., van den Reek, J.M.P.A., Otero, M.E., Atalay, S., Kuijpers, A.L.A., Koetsier, M.I.A., Arnold, W.P., Berends, M.A., Weppner‐Parren, L., Bijen, M., Njoo, M.D., Mommers, J.M., van Lümig, P.P.M., Driessen, R.J.B., Kievit, W., and de Jong, E.M.G.J.

Published
2017
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25. Influence of Ti substitution on magnetic and magnetocaloric properties of Pr2Fe17-xTix intermetallic compounds.

Author

Cengiz, N. E., Pektas, M., Kaya, A. O., Bayri, N., Izgi, T., Gencer, H., Kolat, V. S., and Atalay, S.

Subjects
MAGNETIC entropy, MAGNETIC transitions, MAGNETIC properties, INTERMETALLIC compounds, MAGNETIC measurements, CRITICAL exponents, MAGNETIC fields
Abstract

The structural, magnetic, and magnetocaloric properties of the Pr2Fe17-xTix (x = 0, 0.2, 0.4, 0.6) intermetallic compounds prepared by the arc-melting process were investigated. X-ray analyses indicated that all samples are single phase with the rhombohedral Th2Zn17-type structure. The unit-cell volume was determined to increase with the increasing Ti content. The magnetic measurements revealed that the Curie temperature increases with Ti content from 286 K for x = 0 to 337 K for x = 0.6. The maximum value of |ΔSm| tends to decrease from 5.63 J/kg.K for x = 0 to 4.28 J/kg.K for x = 0.6 with increasing Ti content at 5 T magnetic field change. At the same magnetic field change, the relative cooling power (RCP) ranges from 425.17 J/Kg for x = 0 to 385.62 J/Kg for x = 0.6. The critical exponents (β, γ, and δ) determined from magnetocaloric data for x < 0.2 belong to mean-field model with long-range ferromagnetic interaction. A small deviation in the critical exponents of γ and δ for x > 0.4 samples was attributed to inhomogeneous magnetic state of the samples. From the phase analysis, it was concluded that all samples showed a second-order magnetic phase transition. [ABSTRACT FROM AUTHOR]

Published
2023
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28. Dose reduction of biologics in psoriasis

Author

Jong, E.M.G.J. de, Kievit, W., Reek, J.M.P.A. van den, Atalay, S., Jong, E.M.G.J. de, Kievit, W., Reek, J.M.P.A. van den, and Atalay, S.

Abstract

Radboud University, 21 december 2021, Promotor : Jong, E.M.G.J. de Co-promotores : Kievit, W., Reek, J.M.P.A. van den, Contains fulltext : 240236.pdf (Publisher’s version ) (Open Access)

Published
2021

29. Evaluation of a One-step Dose Reduction Strategy of Adalimumab, Etanercept and Ustekinumab in Patients with Psoriasis in Daily Practice

Author

Atalay, S., Schoot, L.S. van der, Vandermaesen, L.M.D., Vugt, L.J. van, Eilander, Mascha, Reek, J.M.P.A. van den, Jong, E.M.G.J. de, Atalay, S., Schoot, L.S. van der, Vandermaesen, L.M.D., Vugt, L.J. van, Eilander, Mascha, Reek, J.M.P.A. van den, and Jong, E.M.G.J. de

Abstract

Contains fulltext : 234405.pdf (Publisher’s version ) (Open Access)

Published
2021

30. Dose reduction of biologics in psoriasis.

Author

Atalay, S. and Atalay, S.

Subjects
Radboud Institute for Health Sciences., Radboudumc 5: Inflammatory diseases., Radboudumc 5: Inflammatory diseases RIHS: Radboud Institute for Health Sciences.
Published
2021

31. Structural, magnetic and magnetocaloric properties of Ru doped Pr0.67Ca0.33Mn1 − xRuxO3 manganites.

Author

Kanıkırmızı, T., İzgi, T., Bayri, N., Gencer, H., Kolat, V. S., Pektas, M., and Atalay, S.

Subjects
MAGNETOCALORIC effects, MAGNETIC properties, MAGNETIC transitions, MANGANESE, CURIE temperature, MAGNETIC moments, MAGNETIZATION measurement
Abstract

We have investigated the influence of ruthenium doping on magnetic and magnetocaloric properties of Pr0.67Ca0.33Mn1 − x RuxO3 (x = 0, 0.05, 0.1, 0.15, 0.2, 0.3, 0.5) compounds. X-ray results revealed that the samples have an orthorhombic structure with Pnma space group. The magnetization analysis also showed that Ru doping destroys CO antiferromagnetic and simultaneously inducing ferromagnetism. Variation of lattice parameters and magnetization measurements revealed the existence of mixed valence states of Ru3+ and Ru4+. With increasing Ru content, a slight increase in Curie temperature and magnetization values was observed until x = 0.15. At further Ru doping rates, a considerable decrease was observed in Curie temperature and saturation magnetization. Such a behavior at high Ru concentration rates in saturation magnetization and Curie temperature was attributed to a smaller magnetic moment of Ru4+ than that of Mn3+ and Mn4+ and increase of AFM interaction between the Ru3+– Mn3+ and Ru3+– Mn4+ pairs. The decrease in |ΔSm| was attributed to the second-order magnetic phase transition and the reduction in saturation magnetization. [ABSTRACT FROM AUTHOR]

Published
2022
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32. Health Economic Consequences of a Tightly Controlled Dose Reduction Strategy for Adalimumab, Etanercept and Ustekinumab Compared with Standard Psoriasis Care: A Cost-utility Analysis of the CONDOR Study

Author

Atalay, S., Reek, J.M.P.A. van den, Otero, M.E., Njoo, M.D., Mommers, J.M., Ossenkoppele, P.M., Koetsier, M.I., Berends, M.A.M., Kerkhof, P.C.M. van de, Groenewoud, H., Broeder, A.A. den, Jong, E.M.G.J. de, Kievit, W., Atalay, S., Reek, J.M.P.A. van den, Otero, M.E., Njoo, M.D., Mommers, J.M., Ossenkoppele, P.M., Koetsier, M.I., Berends, M.A.M., Kerkhof, P.C.M. van de, Groenewoud, H., Broeder, A.A. den, Jong, E.M.G.J. de, and Kievit, W.

Abstract

Contains fulltext : 229433.pdf (publisher's version ) (Open Access), A dose reduction strategy for adalimumab, etanercept and ustekinumab in patients with psoriasis who have stable and low disease activity has recently been compared with usual care in the CONDOR study (CONtrolled DOse Reduction) of biologics in patients with psoriasis with low disease activity. The aim of the current study was to perform a cost-utility analysis with a 12-month time horizon alongside this trial, using prospectively measured healthcare costs and quality-adjusted life years, based on Short-Form Six-Dimension utilities. Bootstrap analys-es were used to calculate the decremental cost-utility ratio and the incremental net monetary benefit. The dose reduction strategy resulted in a mean cost saving of €3,820 (95th percentile -€3,099 to -€4,509) per patient over a period of 12 months. There was an 83% chance that dose reduction would result in a reduction in quality adjusted life years (mean -0.02 (95th percentile -0.06 to 0.02). In conclusion, dose reduction of biologics resulted in substantial cost savings with an acceptable reduction in quality of life.

Published
2020

33. Comparison of Tightly Controlled Dose Reduction of Biologics With Usual Care for Patients With Psoriasis A Randomized Clinical Trial

Author

Atalay, S., Reek, J.M.P.A. van den, Broeder, A.A. den, Vugt, L.J. van, Otero, M.E., Njoo, M.D., Kerkhof, Peter C.M. van de, Groenewoud, H., Kievit, W., Jong, E.M.G.J. de, Atalay, S., Reek, J.M.P.A. van den, Broeder, A.A. den, Vugt, L.J. van, Otero, M.E., Njoo, M.D., Kerkhof, Peter C.M. van de, Groenewoud, H., Kievit, W., and Jong, E.M.G.J. de

Abstract

Contains fulltext : 218548.pdf (publisher's version ) (Closed access)

Published
2020

38. Health Economic Consequences of a Tightly Controlled Dose Reduction Strategy for Adalimumab, Etanercept and Ustekinumab Compared with Standard Psoriasis Care: A Cost-utility Analysis of the CONDOR Study

Author

Atalay, S, primary, Reek, J, additional, Otero, M, additional, Njoo, M, additional, Mommers, J, additional, Ossenkoppele, P, additional, Koetsier, M, additional, Berends, M, additional, Kerkhof, P, additional, Groenewoud, H, additional, Broeder, A, additional, Jong, E, additional, and Kievit, W, additional

Published
2020
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39. Structural, magnetic, and magnetocaloric properties of (1 − x)La0.7Ca0.3MnO3/(x)La0.7Ag0.3MnO3 composites.

Author

Yigiter, N., Pektas, M., Kolat, V. S., Izgi, T., Bayri, N., Gencer, H., and Atalay, S.

Subjects
MAGNETOCALORIC effects, MAGNETIC transitions, LANDAU theory, MAGNETIC entropy, MAGNETIC measurements, MAGNETIC fields, MANGANESE alloys
Abstract

In this study, structural, magnetic, and magnetocaloric properties of (1 − x)La0.7Ca0.3MnO3/(x)La0.7Ag0.3MnO3 (x = 0, 0.25, 0.50, 0.75, and 1) composites were investigated in detail. The X-ray diffraction has indicated that the samples have a single phase without any detectable impurity. SEM analysis revealed that samples consist of irregularly shaped and strongly connected particles and grain boundaries become unclear with increasing x. The magnetic measurements revealed that the parent compounds exhibit a ferromagnetic to paramagnetic phase transition. The magnetization curves for composite samples exhibited two magnetic phase transitions nearly same temperature that of the parent compounds. The maximum value of magnetic entropy change (|∆Sm|) decreased from 8.02 for x = 0 to 4.1 J/kg K for x = 0.75 at 5 T magnetic field change. Overlapping entropy peaks becomes almost flat over a wide temperature range for composite samples inducing an enhancement of the RCP (= 273.96 J/kg for x = 0.75 at 5 T magnetic field change). Arrott plots showed a second-order magnetic phase transition for composite samples and also confirmed in terms of Landau theory. [ABSTRACT FROM AUTHOR]

Published
2022
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40. Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin

Author

Bogaard, E.H.J. van den, Geel, M. van, Vlijmen-Willems, I.M.J.J. van, Jansen, P.A.M., Peppelman, M., Erp, P.E.J. van, Atalay, S., Venselaar, H., Simon, M.E., Joosten, M., Schalkwijk, J., Zeeuwen, P.L.J.M., Bogaard, E.H.J. van den, Geel, M. van, Vlijmen-Willems, I.M.J.J. van, Jansen, P.A.M., Peppelman, M., Erp, P.E.J. van, Atalay, S., Venselaar, H., Simon, M.E., Joosten, M., Schalkwijk, J., and Zeeuwen, P.L.J.M.

Abstract

Contains fulltext : 205151.pdf (publisher's version ) (Open Access), PURPOSE: We aimed to assess the biological and clinical significance of the human cysteine protease inhibitor cystatin M/E, encoded by the CTS6 gene, in diseases of human hair and skin. METHODS: Exome and Sanger sequencing was performed to reveal the genetic cause in two related patients with hypotrichosis. Immunohistochemical, biophysical, and biochemical measurements were performed on patient skin and 3D-reconstructed skin from patient-derived keratinocytes. RESULTS: We identified a homozygous variant c.361C>T (p.Gln121*), resulting in a premature stop codon in exon 2 of CST6 associated with hypotrichosis, eczema, blepharitis, photophobia and impaired sweating. Enzyme assays using recombinant mutant cystatin M/E protein, generated by site-directed mutagenesis, revealed that this p.Gln121* variant was unable to inhibit any of its three target proteases (legumain and cathepsins L and V). Three-dimensional protein structure prediction confirmed the disturbance of the protease/inhibitor binding sites of legumain and cathepsins L and V in the p.Gln121* variant. CONCLUSION: The herein characterized autosomal recessive hypotrichosis syndrome indicates an important role of human cystatin M/E in epidermal homeostasis and hair follicle morphogenesis.

Published
2019

41. Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin

Author

van den Bogaard, EHJ, van Geel, M, van Vlijmen-Willems, I, Jansen, PAM, Peppelman, M, van Erp, PEJ, Atalay, S, Venselaar, H, Simon, MEH, Joosten, Marieke, Schalkwijk, J, Zeeuwen, P, van den Bogaard, EHJ, van Geel, M, van Vlijmen-Willems, I, Jansen, PAM, Peppelman, M, van Erp, PEJ, Atalay, S, Venselaar, H, Simon, MEH, Joosten, Marieke, Schalkwijk, J, and Zeeuwen, P

Published
2019

43. Investigation of bacterial and viral etiology in community acquired central nervous system infections with molecular methods [Toplum Kökenli Santral Sinir Sistemi Enfeksiyonlarinda Bakteriyel ve Viral Etiyolojinin Moleküler Yöntemlerle Deǧerlendirilmesi]

Author

Kahraman, H. and Tünger, A. and Şenol, S. and Gazi, H. and Avci, M. and Örmen, B. and Türker, N. and Atalay, S. and Köse, S. and Ulusoy, S. and Taşbakan, M.I. and Sipahi, O.R. and Yamazhan, T. and Gülay, Z. and Çavuş, S.A. and Pullukçu, H., Sabuncuoǧlu Şerefeddin Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Amasya, Turkey, Ege University, Faculty of Medicine, Department of Medical Microbiology, Izmir, Turkey, Celal Bayar University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Manisa, Turkey, Celal Bayar University, Faculty of Medicine, Department of Medical Microbiology, Manisa, Turkey, Bozyaka Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Izmir, Turkey, Ataturk Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Izmir, Turkey, Tepecik Training and Research Hospital, Department of Infectious Diseases and Clinical Microbiology, Izmir, Turkey, Ege University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Izmir, Turkey, Dokuz Eylul University, Faculty of Medicine, Department of Medical Microbiology, Izmir, Turkey, and Dokuz Eylul University, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Izmir, Turkey

Abstract

In this multicenter prospective cohort study, it was aimed to evaluate the bacterial and viral etiology in community-acquired central nervous system infections by standart bacteriological culture and multiplex polymerase chain reaction (PCR) methods. Patients hospitalized with central nervous system infections between April 2012 and February 2014 were enrolled in the study. Demographic and clinical information of the patients were collected prospectively. Cerebrospinal fluid (CSF) samples of the patients were examined by standart bacteriological culture methods, bacterial multiplex PCR (Seeplex meningitis-B ACE Detection (Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae, Listeria monocytogenes, Group B streptococci) and viral multiplex PCR (Seeplex meningitis-VI ACE Detection kits herpes simplex virus-1(HSV1), herpes simplex virus-2(HSV2), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein Barr virus (EBV) and human herpes virus 6 (HHV6)) (Seeplex meningitis-V2 ACE Detection kit (enteroviruses)). Patients were classified as purulent meningitis, aseptic meningitis and encephalitis according to their clinical, CSF (leukocyte level, predominant cell type, protein and glucose (blood/CSF) levels) and cranial imaging results. Patients who were infected with a pathogen other than the detection of the kit or diagnosed as chronic meningitis and other diseases during the follow up, were excluded from the study. A total of 79 patients (28 feMale, 51 Male, aged 42.1 ±18.5) fulfilled the study inclusion criteria. A total of 46 patients were classified in purulent meningitis group whereas 33 were in aseptic meningitis/encephalitis group. Pathogens were detected by multiplex PCR in 41 patients. CSF cultures were positive in 10 (21.7%) patients (nine S.pneumoniae, one H.influenzae) and PCR were positive for 27 (58.6%) patients in purulent meningitis group. In this group one type of bacteria were detected in 18 patients (14 S.pneumoniae, two N.meningitidis, one H.influenzae, one Lmonocytogenes). Besides, it is noteworthy that multiple pathogens were detected such as bacteria-virus combination in eight patients and two different bacteria in one patient. In the aseptic meningitis/encephalitis group, pathogens were detected in 14 out of 33 patients; single type of viruses in 11 patients (seven enterovirus, two HSV1, one HSV2, one VZV) and two different viruses were determined in three patients. These data suggest that multiplex PCR methods may increase the isolation rate of pathogens in central nervous system infections. Existence of mixed pathogen growth is remarkable in our study. Further studies are needed for the clinical relevance of this result.

Published
2017

44. Investigation of bacterial and viral etiology in community acquired central nervous system infections with molecular methods [Toplum Kökenli Santral Sinir Sistemi Enfeksiyonlarinda Bakteriyel ve Viral Etiyolojinin Moleküler Yöntemlerle Degerlendirilmesi]

Author

Kahraman H., Tünger A., Şenol S., Gazi H., Avci M., Örmen B., Türker N., Atalay S., Köse S., Ulusoy S., Taşbakan M.I., Sipahi O.R., Yamazhan T., Gülay Z., Çavuş S.A., Pullukçu H., and Ege Üniversitesi

Subjects
ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS, ComputingMethodologies_PATTERNRECOGNITION, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, Encephalitis, Mixed infection, Viral menengitis, InformationSystems_MISCELLANEOUS, Acute bacterial meningitis, Polymerase chain reaction
Abstract

PubMed ID: 28929964, In this multicenter prospective cohort study, it was aimed to evaluate the bacterial and viral etiology in community-acquired central nervous system infections by standart bacteriological culture and multiplex polymerase chain reaction (PCR) methods. Patients hospitalized with central nervous system infections between April 2012 and February 2014 were enrolled in the study. Demographic and clinical information of the patients were collected prospectively. Cerebrospinal fluid (CSF) samples of the patients were examined by standart bacteriological culture methods, bacterial multiplex PCR (Seeplex meningitis-B ACE Detection (Streptococcus pneumoniae, Neisseria meningitidis, Haemophilus influenzae, Listeria monocytogenes, Group B streptococci) and viral multiplex PCR (Seeplex meningitis-VI ACE Detection kits herpes simplex virus-1(HSV1), herpes simplex virus-2(HSV2), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein Barr virus (EBV) and human herpes virus 6 (HHV6)) (Seeplex meningitis-V2 ACE Detection kit (enteroviruses)). Patients were classified as purulent meningitis, aseptic meningitis and encephalitis according to their clinical, CSF (leukocyte level, predominant cell type, protein and glucose (blood/CSF) levels) and cranial imaging results. Patients who were infected with a pathogen other than the detection of the kit or diagnosed as chronic meningitis and other diseases during the follow up, were excluded from the study. A total of 79 patients (28 feMale, 51 Male, aged 42.1 ±18.5) fulfilled the study inclusion criteria. A total of 46 patients were classified in purulent meningitis group whereas 33 were in aseptic meningitis/encephalitis group. Pathogens were detected by multiplex PCR in 41 patients. CSF cultures were positive in 10 (21.7%) patients (nine S.pneumoniae, one H.influenzae) and PCR were positive for 27 (58.6%) patients in purulent meningitis group. In this group one type of bacteria were detected in 18 patients (14 S.pneumoniae, two N.meningitidis, one H.influenzae, one Lmonocytogenes). Besides, it is noteworthy that multiple pathogens were detected such as bacteria-virus combination in eight patients and two different bacteria in one patient. In the aseptic meningitis/encephalitis group, pathogens were detected in 14 out of 33 patients; single type of viruses in 11 patients (seven enterovirus, two HSV1, one HSV2, one VZV) and two different viruses were determined in three patients. These data suggest that multiplex PCR methods may increase the isolation rate of pathogens in central nervous system infections. Existence of mixed pathogen growth is remarkable in our study. Further studies are needed for the clinical relevance of this result.

Published
2017

45. Effects of Ru substitution on the structural, magnetic and magnetocaloric properties of Pr0.68Ca0.22Sr0.1Mn1−xRuxO3 (x = 0, 0.05, 0.1 and 0.2) compounds.

Author

Pektas, M., Izgi, T., Gencer, H., Atalay, S., Kolat, V. S., and Bayri, N.

Subjects
PRASEODYMIUM, MAGNETIC properties, ALKALINE earth metals, MAGNETIC moments, CURIE temperature, LATTICE constants, PHASE transitions
Abstract

The structural, magnetic and magnetocaloric properties of polycrystalline Pr0.68Ca0.22Sr0.1Mn1−xRuxO3 (x = 0, 0.05, 0.1 and 0.2) compounds were studied. All the samples crystallized in an orthorhombic symmetry. A significant increase in the lattice parameters in the doped samples was attributed to the existence of Ru with a the mixed-valence state (Ru3+/Ru4+). The increase in the Curie temperature (Tc) with increasing Ru content was interpreted as Ru doping promoting the ferromagnetic interactions between Ru4+–Mn3+ and Ru4+–Mn4+pairs. The decrease in saturation magnetisation was attributed to an AFM interaction between the Ru3+–Mn3+ and Ru3+–Mn4+ pairs and smaller magnetic moments of Ru than those of Mn. The decrease in |ΔSM| (from 4.66 J kg−1 K−1 for x = 0.05 to 2.32 J kg−1 K−1 for x = 0.2 at 5 T) was attributed to the nature of phase transition (from a first-order to second-order transition) and a decrease in the saturation magnetisation. [ABSTRACT FROM AUTHOR]

Published
2020
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48. Tight controlled dose reduction of biologics in psoriasis patients with low disease activity: a randomized pragmatic non-inferiority trial

Author

Atalay, S., Reek, J.M.P.A. van den, Vugt, L.J. van, Otero, M.E., Kerkhof, P.C.M. van de, Broeder, A.A. den, Kievit, W., Jong, E.M.G.J. de, Atalay, S., Reek, J.M.P.A. van den, Vugt, L.J. van, Otero, M.E., Kerkhof, P.C.M. van de, Broeder, A.A. den, Kievit, W., and Jong, E.M.G.J. de

Abstract

Contains fulltext : 174225.pdf (publisher's version ) (Open Access), BACKGROUND: Psoriasis is an immune-mediated chronic inflammatory skin disorder for which several targeted biologic therapies became available in the last 10 years. Data from patients with rheumatoid arthritis revealed that dose tapering combined with tight control of disease activity is successful. For psoriasis patients the lowest effective dose of biologics needs to be determined. The objective was to assess whether dose tapering of biologics guided by Psoriasis Area and Severity Index (PASI) and Dermatology Quality of Life Index (DLQI) scores in psoriasis patients with controlled disease activity is non-inferior (NI) to usual care. METHODS/DESIGN: This is a multicenter, pragmatic, randomized, non-inferiority trial with cost- effectiveness analysis. One hundred and twenty patients with stable low disease activity (PASI

Published
2017

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