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Your search keyword '"Bagnarelli, Luca"' showing total 27 results
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27 results on '"Bagnarelli, Luca"'

5. Novel Silver Complexes Based on Phosphanes and Ester Derivatives of Bis(pyrazol-1-yl)acetate Ligands Targeting TrxR: New Promising Chemotherapeutic Tools Relevant to SCLC Management

Author

Pellei, Maura, primary, Santini, Carlo, additional, Bagnarelli, Luca, additional, Caviglia, Miriam, additional, Sgarbossa, Paolo, additional, De Franco, Michele, additional, Zancato, Mirella, additional, Marzano, Cristina, additional, and Gandin, Valentina, additional

Published
2023
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6. Exploring the Antitumor Potential of Copper Complexes Based on Ester Derivatives of Bis(pyrazol-1-yl)acetate Ligands

Author

Pellei, Maura, primary, Santini, Carlo, additional, Bagnarelli, Luca, additional, Battocchio, Chiara, additional, Iucci, Giovanna, additional, Venditti, Iole, additional, Meneghini, Carlo, additional, Amatori, Simone, additional, Sgarbossa, Paolo, additional, Marzano, Cristina, additional, De Franco, Michele, additional, and Gandin, Valentina, additional

Published
2022
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7. Cu(I) and Cu(II) Complexes Based on Lonidamine-Conjugated Ligands Designed to Promote Synergistic Antitumor Effects

Author

Del Bello, Fabio, primary, Pellei, Maura, additional, Bagnarelli, Luca, additional, Santini, Carlo, additional, Giorgioni, Gianfabio, additional, Piergentili, Alessandro, additional, Quaglia, Wilma, additional, Battocchio, Chiara, additional, Iucci, Giovanna, additional, Schiesaro, Irene, additional, Meneghini, Carlo, additional, Venditti, Iole, additional, Ramanan, Nitya, additional, De Franco, Michele, additional, Sgarbossa, Paolo, additional, Marzano, Cristina, additional, and Gandin, Valentina, additional

Published
2022
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19. Synthesis and Cytotoxic Activity Evaluation of New Cu(I) Complexes of Bis(pyrazol-1-yl) Acetate Ligands Functionalized with an NMDA Receptor Antagonist

Author

Pellei, Maura, primary, Bagnarelli, Luca, additional, Luciani, Lorenzo, additional, Del Bello, Fabio, additional, Giorgioni, Gianfabio, additional, Piergentili, Alessandro, additional, Quaglia, Wilma, additional, De Franco, Michele, additional, Gandin, Valentina, additional, Marzano, Cristina, additional, and Santini, Carlo, additional

Published
2020
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20. Development of new and efficient copper(ii) complexes of hexyl bis(pyrazolyl)acetate ligands as catalysts for allylic oxidation

Author

Gabrielli, Serena, primary, Pellei, Maura, additional, Venditti, Iole, additional, Fratoddi, Ilaria, additional, Battocchio, Chiara, additional, Iucci, Giovanna, additional, Schiesaro, Irene, additional, Meneghini, Carlo, additional, Palmieri, Alessandro, additional, Marcantoni, Enrico, additional, Bagnarelli, Luca, additional, Vallesi, Riccardo, additional, and Santini, Carlo, additional

Published
2020
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26. Exploring the Antitumor Potential of Copper Complexes Based on Ester Derivatives of Bis(pyrazol-1-yl)acetate Ligands

Author

Maura Pellei, Carlo Santini, Luca Bagnarelli, Chiara Battocchio, Giovanna Iucci, Iole Venditti, Carlo Meneghini, Simone Amatori, Paolo Sgarbossa, Cristina Marzano, Michele De Franco, Valentina Gandin, Pellei, Maura, Santini, Carlo, Bagnarelli, Luca, Battocchio, Chiara, Iucci, Giovanna, Venditti, Iole, Meneghini, Carlo, Amatori, Simone, Sgarbossa, Paolo, Marzano, Cristina, De Franco, Michele, and Gandin, Valentina

Subjects
XAS, Ligand, Acetates, Ligands, Crystallography, X-Ray, Catalysis, Inorganic Chemistry, Coordination Complexes, Humans, Ester, Physical and Theoretical Chemistry, Molecular Biology, bis(pyrazolyl)acetate ligands, Spectroscopy, bis(pyrazolyl)acetate ligand, Crystallography, Coordination Complexe, SR-XPS, Acetate, Organic Chemistry, Esters, General Medicine, Computer Science Applications, copper, cytotoxicity, Cisplatin, Copper, X-Ray, Human
Abstract

Bis(pyrazol-1-yl)acetic acid (HC(pz)2COOH) and bis(3,5-dimethyl-pyrazol-1-yl)acetic acid (HC(pzMe2)2COOH) were converted into the methyl ester derivatives 1 (LOMe) and 2 (L2OMe), respectively, and were used for the preparation of Cu(I) and Cu(II) complexes 3–10. The copper(II) complexes were prepared by the reaction of CuCl2·2H2O or CuBr2 with ligands 1 and 2 in methanol solution. The copper(I) complexes were prepared by the reaction of Cu[(CH3CN)4]PF6 and 1,3,5-triaza-7-phosphaadamantane (PTA) or triphenylphosphine with LOMe and L2OMe in acetonitrile solution. Synchrotron radiation-based complementary techniques (XPS, NEXAFS, and XAS) were used to investigate the electronic and molecular structures of the complexes and the local structure around copper ions in selected Cu(I) and Cu(II) coordination compounds. All Cu(I) and Cu(II) complexes showed a significant in vitro antitumor activity, proving to be more effective than the reference drug cisplatin in a panel of human cancer cell lines, and were able to overcome cisplatin resistance. Noticeably, Cu complexes appeared much more effective than cisplatin in 3D spheroid cultures. Mechanistic studies revealed that the antitumor potential did not correlate with cellular accumulation but was consistent with intracellular targeting of PDI, ER stress, and paraptotic cell death induction.

Published
2022
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27. Development of new and efficient copper(ii) complexes of hexyl bis(pyrazolyl)acetate ligands as catalysts for allylic oxidation

Author

Carlo Santini, Alessandro Palmieri, Maura Pellei, Iole Venditti, Carlo Meneghini, Giovanna Iucci, Chiara Battocchio, Ilaria Fratoddi, Irene Schiesaro, Luca Bagnarelli, Enrico Marcantoni, Serena Gabrielli, Riccardo Vallesi, Gabrielli, Serena, Pellei, Maura, Venditti, Iole, Fratoddi, Ilaria, Battocchio, Chiara, Iucci, Giovanna, Schiesaro, Irene, Meneghini, Carlo, Palmieri, Alessandro, Marcantoni, Enrico, Bagnarelli, Luca, Vallesi, Riccardo, and Santini, Carlo

Subjects
chemistry.chemical_classification, conjugates, Allylic rearrangement, Chemistry, Reducing agent, Alkene, Ligand, Copper(I) complexes, chemistry.chemical_element, Copper, anticancer compounds, Catalysis, Inorganic Chemistry, X-ray photoelectron spectroscopy, Yield (chemistry), gold nanoparticles, Polymer chemistry, drug delivery
Abstract

In this study, two new hexyl bis(pyrazol-1-yl)acetate ligands and related copper(ii) complexes were prepared and fully characterized in the solid state and in solution. Their electronic and molecular structures were investigated by X-ray photoelectron spectroscopy and near edge X-ray absorption; their ligand molecular structural stability upon coordination to copper was also investigated. The Cu(ii) complexes were studied as new catalysts in copper-catalyzed C-H oxidation for allylic functionalization (the Kharasch-Sosnovsky reaction) avoiding the use of any external reducing agents. Using 5 mol% of these catalysts and tert-butylperoxybenzoate as the oxidant, allylic benzoates were obtained in up to 90% yield: the general reaction time was decreased to 6 h and a 5 to 1 ratio of the alkene and tert-butylperoxybenzoate was used to overcome the two most important limitations on their use in chemistry.

Published
2020

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