363 results on '"Bagolan, P."'
Search Results
2. Congenital lung malformations: a nationwide survey on management aspects by the Italian Society of Pediatric Surgery
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Pio, Luca, Gentilino, Valerio, Macchini, Francesco, Scarpa, Alberto Attilio, Lo Piccolo, Roberto, Conforti, Andrea, Ratta, Alberto, Guanà, Riccardo, Molinaro, Francesco, Costanzo, Sara, Riccipetitoni, Giovanna, Lisi, Gabriele, Midrio, Paola, Tocchioni, Francesca, Cobellis, Giovannii, Volpe, Andrea, Zolpi, Elisa, Morandi, Anna, Ciardini, Enrico, Vella, Claudio, Grella, Maria Giovanna, Sergio, Maria, Guida, Edoardo, Nanni, Lorenzo, Ceccanti, Silvia, Di Benedetto, Vincenzo, Cheli, Maurizio, Garzi, Alfredo, Nobili, Maria, Gabriele, Valeria, Boroni, Giovanni, Incerti, Filippo, Zampieri, Nicola, Cacciaguerra, Sebastiano, Ceccarelli, Pier Luca, Escolino, Maria, Briganti, Vito, Gori, Davide, Esposito, Ciro, Gamba, Piergiorgio, Gennari, Fabrizio, Inserra, Alessandro, Dall’Igna, Patrizia, Romeo, Carmelo, Bagolan, Pietro, Bleve, Cosimo, Chiarenza, Fabio, Morini, Francesco, Pelizzo, Gloria, and Torre, Michele
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- 2024
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3. Assessment of hemodynamic dysfunction in septic newborns by functional echocardiography: a systematic review
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Pugnaloni, Flaminia, De Rose, Domenico Umberto, Kipfmueller, Florian, Patel, Neil, Ronchetti, Maria Paola, Dotta, Andrea, Bagolan, Pietro, Capolupo, Irma, and Auriti, Cinzia
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- 2024
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4. Anorectal malformations (ARM) and VACTERL association and severity of congenital heart diseases (CHD): Experience of 396 consecutive patients in a tertiary center
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Patrizio Moras, Angelo Zarfati, Pietro Bagolan, Andrea Conforti, Alessandra Toscano, and Barbara Daniela Iacobelli
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Anorectal malformations ,ARM ,VACTERL ,VACTERL association ,Congenital heart disease ,CHD ,Pediatrics ,RJ1-570 - Abstract
Objective: Congenital heart diseases (CHD) are the most frequently associated anomalies with anorectal malformations (ARM). Nevertheless, many specific aspects of CHD in ARM patients have yet to be studied. The aims of this study were to evaluate the prevalence and distribution of CHD in neonates-infants with ARM, and to explore whether the severity of ARM, and the presence of VACTERL association, had an impact on CHD rate, severity, and timing at first cardiac surgery. Study design: All consecutive newborn-infants with ARM managed in our tertiary center (January-1999; December-2021) were collected from a prospective database and retrospectively analyzed. Prevalence and distribution of CHD in ARM patients were assessed. Patients were divided into groups depending on ARM severity and presence of VACTERL association. Pairwise comparison for CHD prevalence, severity, and timing at first cardiac surgery was performed between groups. Results: Of 396 ARM patients identified, those with severe ARM showed a higher number of overall CHD compared to patients with non-severe ARM (36.7 % vs. 25.2 %, p = 0.032). VACTERL + patients had a significantly higher prevalence of CHD (73.4 % vs. 16.4 %; p
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- 2024
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5. Decreased incidence of late-onset sepsis during the SARS-CoV-2 pandemic in Italy: a multicentric study on a cohort of infants requiring major surgery
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De Rose, Domenico Umberto, Santisi, Alessandra, Ronchetti, Maria Paola, Martini, Ludovica, Serafini, Lisa, Betta, Pasqua, Maino, Marzia, Cavigioli, Francesco, Giuffré, Mario, Bonanno, Elvira, Tzialla, Chryssoula, Bua, Jenny, Pugni, Lorenza, Della Torre, Benedetta, Nardella, Giovanna, Mazzeo, Danila, Ravà, Lucilla, Bagolan, Pietro, Dotta, Andrea, and Auriti, Cinzia
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- 2023
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6. Use of N-Acetylcysteine in Preterm Neonates with Enteral Feeding Intolerance and Intestinal Obstruction: A Case Series and Review of the Literature
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Domenico Umberto De Rose, Francesca Landolfo, Flaminia Pugnaloni, Paola Giliberti, Alessandra Santisi, Claudia Columbo, Ludovica Martini, Maria Paola Ronchetti, Paolo Maria Schingo, Guglielmo Salvatori, Fabio Fusaro, Pietro Bagolan, Andrea Dotta, Irma Capolupo, and Andrea Conforti
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meconium obstruction ,Fluimucil ,intestinal obstruction ,acute abdomen ,Pediatrics ,RJ1-570 - Abstract
(1) Background: The use of N-acetylcysteine (NAC) to relieve meconium obstruction of prematurity in the first days of life has been reported, with NAC reducing the viscosity of luminal contents by cleaving the disulfide bonds of mucoproteins. However, its use in this population should be further explored since it has been associated with hypernatremia and transient increase in transaminases and bilirubin. (2) Methods: In this retrospective study, we included neonates admitted because of enteral feeding intolerance and intestinal obstruction from 2019 to 2021 who received NAC as a rescue therapy before explorative laparotomy. (3) Results: We summarized the clinical presentation of six preterm neonates with enteral feeding intolerance and intestinal obstruction who received NAC as a rescue therapy. Four infants (66.7%) gradually improved without the need for explorative laparotomy, whereas two infants (33.3%) underwent the creation of an ileostomy. No cases of hypernatremia or hepatic derangement associated with NAC therapy were observed. (4) Conclusions: We described the use of NAC treatment by nasogastric tube and/or rectal enemas in preterm infants with enteral feeding intolerance and intestinal obstruction after a multidisciplinary assessment, but the limited sample size did not allow us to obtain definitive conclusions and further research is needed in this field, given the limited evidence about NAC treatment in preterm infants.
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- 2024
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7. Biliary atresia in preterm infants: a single center experience and review of literature
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Federico Beati, Antonella Mosca, Andrea Pietrobattista, Daniela Liccardo, Sara Ronci, Lidia Monti, Paola Francalanci, Marco Spada, Giuseppe Maggiore, Pietro Bagolan, and Fabio Fusaro
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biliary atresia—common cause of obstructive jaundice in young infants ,Kasai portoenterostomy (KPE) ,clearance of jaundice ,neonatal cholestasis ,pediatric liver transplant ,native liver survival ,Surgery ,RD1-811 - Abstract
IntroductionThe diagnosis of biliary atresia (BA) remains challenging, and there is still uncertainty regarding the optimal time to perform a Kasai portoenterostomy (KPE). Little is known about the difficulties in the diagnosis and outcomes of BA in preterm infants (PBA). This study, which represents the first Italian report of preterm infants with BA, aims to describe a single-center experience of BA in preterm newborns.MethodsWe retrospectively reviewed all infants consecutively diagnosed with BA who underwent a Kasai procedure at the Bambino Gesù Children’s Hospital between January 1998 and December 2021. Prematurity was defined as a gestational age (GA) of
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- 2024
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8. Long-term urological outcome of cloaca patients with multidisciplinary management
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Pellegrino, C., Agamennone, M., Iacobelli, B. D., Turchi, B., Capitanucci, M. L., Beati, F., Forlini, V., Sollini, M. L., Marras, C. E., Esposito, G., Palma, P., Bella, G. Della, D’Urzo, R., Caldaro, T., Castelli, E., Conforti, A., Bagolan, P., and Mosiello, G.
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- 2023
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9. Hypospadias management in children with anorectal malformation: a multidisciplinary single center experience
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Forlini, Valentina, Pellegrino, Chiara, Capitanucci, Maria Luisa, Beati, Federico, Iacobelli, Barbara Daniela, Conforti, Andrea, Sollini, Maria Laura, Turchi, Beatrice, Agamennone, Marco, Marras, Carlo Efisio, Esposito, Giacomo, Palma, Paolo, Della Bella, Gessica, D’urzo, Rossella, Castelli, Enrico, Bagolan, Pietro, and Mosiello, Giovanni
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- 2023
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10. Continence management in children with severe caudal regression syndrome: role of multidisciplinary team and long-term follow-up
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Esposito, Giacomo, Totonelli, Giorgia, Iacobelli, Barbara Daniela, Longo, Daniela, Caldaro, Tamara, Blasetti, Giulia, Bevilacqua, Francesca, Santato, Francesca, Lucignani, Giulia, Sollini, Maria Laura, Marras, Carlo Efisio, Bagolan, Pietro, and Mosiello, Giovanni
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- 2022
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11. Anorectal malformation, urethral duplication, occult spinal dysraphism (ARM-UD-OSD): a challenging uncommon association
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Lena, Federica, Pellegrino, Chiara, Zaccara, Antonio Maria, Capitanucci, Maria Luisa, Esposito, Giacomo, Iacobelli, Barbara Daniela, Longo, Daniela, Caldaro, Tamara, Bruno, Diletta, Bevilacqua, Francesca, Santato, Francesca, Lucignani, Giulia, Marras, Carlo Efisio, Castelli, Enrico, Bagolan, Pietro, and Mosiello, Giovanni
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- 2022
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12. How much does a liter of donor human milk cost? Cost analysis of operating a human milk bank in Italy
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Guglielmo Salvatori, Domenico Umberto De Rose, Maria Clemente, Cristina Gentili, Giovanni Paride Verardi, Patrizia Amadio, Maria Paola Reposi, Pietro Bagolan, and Andrea Dotta
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Newborn ,Human milk bank ,Donor human milk ,Pediatrics ,RJ1-570 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background To date, 40 Human Milk Banks (HMB) have been established in Italy; however, recent cost analysis data for operating an HMB in Italy are not available in the literature. Methods This study was a cross-sectional study performed at “Bambino Gesù” Children’s Hospital in Rome, Italy in 2019. We assessed the one-year operational costs and, the per liter unit costs at our HMB. Results During the 2019 year we collected 771 l of human milk supplied by 128 donors. The total cost was € 178,287.00 and the average cost was € 231.00 per liter. € 188,716.00 would have been spent had the maximum capacity for 904 l been reached. We found a significant difference (€ 231.00 vs € 209.00 per liter, p = 0.016) comparing the cost for collected liters in the year 2019 and the cost for the maximum capacity of the bank for that year of activity. Analyzing each cost item that determines the charge of donor human milk (DHM), the highest costs are the salaries of medical and paramedical staff, and then the costs related to transporting. If the HMB works at maximum capacity and manages a greater number of liters of milk, this can represent an important saving. Conversely, the price of consumables is modest (i.e., the price of a single-use kit for breast pumps was € 0.22 per unit). Conclusion The costs for a liter of DHM are quite high, but they must be related to the benefits, especially for preterm infants. Comparing the cost for collected liters in 2019 and the costs for the 2019 maximum capacity of the HMB, we calculated how much fixed costs of collection and distribution of DHM can be reduced, by increasing the volume of milk collected. To the best of our knowledge, this is the first complete cost analysis for an Italian Milk Bank. A thorough analysis could help to abate fixed costs and reduce the cost of a liter of DHM. The centralization of DHM can allow savings, rather than creating small HMBs scattered throughout the territory that would operate with lower milk volumes.
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- 2022
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13. Hemodynamic Assessment of a Large Pulmonary Arteriovenous Malformation in a Neonate: Case Report and Review of Literature
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Giliberti, Paola, De Rose, Domenico Umberto, Landolfo, Francesca, Columbo, Claudia, Pugnaloni, Flaminia, Santisi, Alessandra, Conforti, Andrea, Secinaro, Aurelio, Francalanci, Paola, Bozza, Patrizia, Chukhlantseva, Natalia, Savignoni, Ferdinando, Caforio, Leonardo, Toscano, Alessandra, Novelli, Antonio, Dotta, Andrea, Capolupo, Irma, and Bagolan, Pietro
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- 2022
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14. Incidence and risk factors of bacterial sepsis and invasive fungal infection in neonates and infants requiring major surgery: an Italian multicentre prospective study
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Auriti, C., De Rose, D.U., Santisi, A., Martini, L., Ronchetti, M.P., Ravà, L., Antenucci, V., Bernaschi, P., Serafini, L., Catarzi, S., Fiorini, P., Betta, P., Scuderi, M.G., Di Benedetto, V., Ferrari, S., Maino, M., Cavigioli, F., Cocchi, I., Giuffré, M., Bonanno, E., Tzialla, C., Bua, J., Pugni, L., Della Torre, B., Nardella, G., Mazzeo, D., Manzoni, P., Capolupo, I., Ciofi degli Atti, M., Dotta, A., Stronati, M., Raponi, M., Mosca, F., and Bagolan, P.
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- 2022
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15. Isoperistaltic gastric tube for long gap esophageal atresia (LGEA) in newborn, infants, and toddlers: a case-control study from a tertiary center
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Angelo Zarfati, Renato Tambucci, Pietro Bagolan, and Andrea Conforti
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esophagal atresia ,long-gap atresia ,long-gap ,gastric tube esophagoplasty ,gastric tube ,isoperistaltic gastric tube ,Pediatrics ,RJ1-570 - Abstract
BackgroundLimited evidence exists about outcomes after gastric tube formation as “rescue” technique to avoid esophageal replacement in long gap esophageal atresia (LGEA). The last ERNICA Consensus Conference on the Management of LGEA has placed the techniques of gastric tubulization among the priorities for future research.AimsEvaluate personal experience with Isoperistaltic Gastric Tube (IGT) and compare its outcomes with other more popular techniques for LGEA.MethodsA case-control study has been conducted. A retrospective monocentric analysis of LGEA patients (period: 2010–19) has been conducted in all consecutive IGT patients and each of these has been type matched with two cases of LGEA treated with other techniques. The follow-up (FU) considered was 24-months.ResultsIGT and controls showed no statistically significant differences regarding preoperative variables like sex, gestational age, birth weight, syndromes, and EA type. However, IGT patients had a significantly longer esophageal GAP under boost pressure (4.5 vertebral bodies vs. 3.6, p = 0.019) at time of surgery. The analysis showed no statistical difference among the two groups about perioperative outcomes, ICU, or overall postoperative stay. No differences have been shown between IGT and controls during the follow-up regarding GERD, esophagitis, fundoplication, dysphagia, vocal cord paralysis, stenosis, and dilatations, auxologic data, need for anastomosis revision, oral aversion, and death.ConclusionsIsoperistaltic Gastric Tube is safe and effective even in LGEA patients with longer gaps, with good perioperative, post-operative and middle-term outcomes. This procedure may be considered as an alternative to avoid esophageal substitution when a primary anastomosis seems impossible for a residual gap after traction and growth techniques.
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- 2023
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16. A neonatal report of iliac artery aneurysm
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Costanza Renata Neri, Sara Torresi, Valentina Chiavaroli, Eleonora Coclite, Daniele Galasso, Gianluca Brancaccio, Matteo Trezzi, Fabio Fusaro, Pietro Bagolan, Francesco Chiarelli, and Susanna Di Valerio
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Pediatrics ,RJ1-570 ,Surgery ,RD1-811 - Published
- 2023
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17. SARS-CoV-2 in a Neonate with Truncus Arteriosus: Management and Surgical Correction Timing
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Masci, M., Moras, P., Di Chiara, L., Pasquini, L., Campanale, C. M., Bagolan, P., Galletti, L., and Toscano, A.
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- 2022
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18. Early vasopressin infusion improves oxygenation in infants with congenital diaphragmatic hernia
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Irma Capolupo, Domenico Umberto De Rose, Francesca Mazzeo, Francesca Monaco, Paola Giliberti, Francesca Landolfo, Alessandra Di Pede, Alessandra Toscano, Andrea Conforti, Pietro Bagolan, and Andrea Dotta
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pulmonary hypertension ,CDH ,neonates ,hypotension ,oxygenation index ,near-infrared spectroscopy ,Pediatrics ,RJ1-570 - Abstract
ObjectiveCongenital Diaphragmatic Hernia (CDH) is a complex disease including a diaphragmatic defect, lung hypoplasia, and pulmonary hypertension. Despite its increasing use in neonates, the literature on the use of vasopressin in neonates is limited. The aim of this work is to analyze the changes in clinical and hemodynamic variables in a cohort of CDH infants treated with vasopressin.MethodsAmong CDH infants managed at the Neonatal Intensive Care Unit (NICU) of our hospital from May 2014 to January 2019, all infants who were treated with vasopressin, because of systemic hypotension and pulmonary hypertension, were enrolled in this retrospective study. The primary outcome was the change in oxygenation index (OI) after the start of the infusion of vasopressin. The secondary outcomes were the changes in cerebral and splanchnic fractional tissue oxygen extraction (FTOEc and FTOEs) at near-infrared spectroscopy, to understand the balance between oxygen supply and tissue oxygen consumption after the start of vasopressin infusion. We also reported as secondary outcomes the changes in ratio of arterial oxygen partial pressure (PaO2) to fraction of inspired oxygen (FiO2), heart rate, mean arterial pressure, serum pH, and serum sodium.ResultsWe included 27 patients with isolated CDH who received vasopressin administration. OI dramatically dropped when vasopressin infusion started, with a significant reduction according to ANOVA for repeated measures (p = 0.003). A global significant improvement in FTOEc and FTOEs was detected (p = 0.009 and p = 0.004, respectively) as a significant reduction in heart rate (p = 0.019). A global significant improvement in PaO2/FiO2 ratio was observed (p
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- 2023
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19. Editorial: Unsolved problems in congenital diaphragmatic hernia
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Dick Tibboel, Anne Greenough, Neil Patel, Pietro Bagolan, and Thomas Schaible
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newborn ,congenital diaphragmatic hernia ,ECMO ,pulmonary hypertension ,follow-up ,artificial ventilation ,Pediatrics ,RJ1-570 - Published
- 2023
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20. How much does a liter of donor human milk cost? Cost analysis of operating a human milk bank in Italy
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Salvatori, Guglielmo, De Rose, Domenico Umberto, Clemente, Maria, Gentili, Cristina, Verardi, Giovanni Paride, Amadio, Patrizia, Reposi, Maria Paola, Bagolan, Pietro, and Dotta, Andrea
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- 2022
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21. Reliability of Fetal Echocardiography in Predicting Postnatal Critical Hypoxia in Patients with Transposition of Great Arteries and Intact Ventricular Septum
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Masci, M., Pasquini, L., Alsaied, T., Di Chiara, L., Formigari, R., Galletti, L., Campanale, C. M., Romiti, A., Bonito, M., Bagolan, P., and Toscano, A.
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- 2021
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22. Unsolved problems in CDH follow-up
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Laura Valfré, Andrea Conforti, Francesco Morini, Neil Patel, Francesca Bevilacqua, Maria Chiara Cianci, Pietro Bagolan, and Annabella Braguglia
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congenital diaphragmatic hernia (CDH) ,pulmonary hypertension ,neurodevelopment ,hearing loss ,thoracoscopy ,problems ,Pediatrics ,RJ1-570 - Abstract
In patients affected by CDH, survival beyond the neonatal period continues to increase thanks to technological and pharmacological improvements. Conversely, patients, families and caregivers are more and more frequently facing “new” complex late comorbidities, including chronic pulmonary and cardiac dysfunctions, neurodevelopmental challenges, and specific nutritional requirements, that often require ongoing long-term medical or surgical care. Therefore, late morbidity is now a key focus in clinical care of CDH. The aims of this paper are to stress some of the most important “unsolved problems” for CDH patients at long-term follow-up.
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- 2022
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23. Fetal cardiac dimensions in congenital diaphragmatic hernia: relationship with gestational age and postnatal outcomes
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Massolo, Anna Claudia, Romiti, Anita, Viggiano, Milena, Vassallo, Chiara, Ledingham, Marie Anne, Lanzone, Antonio, Caforio, Leonardo, Bagolan, Pietro, and Patel, Neil
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- 2021
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24. Anorectal malformations (ARM) and VACTERL association and severity of congenital heart diseases (CHD): Experience of 396 consecutive patients in a tertiary center.
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Moras, Patrizio, Zarfati, Angelo, Bagolan, Pietro, Conforti, Andrea, Toscano, Alessandra, and Iacobelli, Barbara Daniela
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CONGENITAL heart disease ,NEONATAL surgery ,HUMAN abnormalities ,CARDIAC surgery - Abstract
Congenital heart diseases (CHD) are the most frequently associated anomalies with anorectal malformations (ARM). Nevertheless, many specific aspects of CHD in ARM patients have yet to be studied. The aims of this study were to evaluate the prevalence and distribution of CHD in neonates-infants with ARM, and to explore whether the severity of ARM, and the presence of VACTERL association, had an impact on CHD rate, severity, and timing at first cardiac surgery. All consecutive newborn-infants with ARM managed in our tertiary center (January-1999; December-2021) were collected from a prospective database and retrospectively analyzed. Prevalence and distribution of CHD in ARM patients were assessed. Patients were divided into groups depending on ARM severity and presence of VACTERL association. Pairwise comparison for CHD prevalence, severity, and timing at first cardiac surgery was performed between groups. Of 396 ARM patients identified, those with severe ARM showed a higher number of overall CHD compared to patients with non-severe ARM (36.7 % vs. 25.2 %, p = 0.032). VACTERL + patients had a significantly higher prevalence of CHD (73.4 % vs. 16.4 %; p <0.001) and major CHD (51.7 % vs. 26.9 %; p = 0.008) when compared with VACTERL-patients. Furthermore, VACTERL + patients underwent first cardiac surgery at a significantly younger age than VACTERL-patients (5.2 ± 15.2 months vs. 11.9 ± 6.3, p = 0.039). Patients with severe ARM had a higher number of CHD compared to patients with non-severe ARM. VATERL + patients had significantly more CHD and more severe CHD than VACTERL-patients. Early screening for CHD is strongly recommended in all newborns diagnosed with ARM before surgery. III retrospective comparative study. [ABSTRACT FROM AUTHOR]
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- 2024
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25. Bedside surgery in the newborn infants: survey of the Italian society of pediatric surgery
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Gloria Pelizzo, Pietro Bagolan, Francesco Morini, Mariagrazia Aceti, Daniele Alberti, Mario Andermarcher, Luigi Avolio, Fabio Bartoli, Vito Briganti, Sebastiano Cacciaguerra, Francesco S. Camoglio, Pierluca Ceccarelli, Maurizio Cheli, Fabio Chiarenza, Enrico Ciardini, Marcello Cimador, Ennio Clemente, Denis A. Cozzi, Luigi Dall’ Oglio, Ugo De Luca, Carmine Del Rossi, Ciro Esposito, Diego Falchetti, Silvana Federici, Piergiorgio Gamba, Valerio Gentilino, Girolamo Mattioli, Ascanio Martino, Mario Messina, Bruno Noccioli, Alessandro Inserra, Pierluigi Lelli Chiesa, Ernesto Leva, Francesco Licciardi, Paola Midrio, Maria Nobili, Alfonso Papparella, Guglielmo Paradies, Giuseppe Piazza, Alessio Pini Prato, Fabio Rossi, Giovanna Riccipetitoni, Carmelo Romeo, Domenico Salerno, Alessandro Settimi, Jurgen Schleef, Mario Milazzo, Valeria Calcaterra, and Mario Lima
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Neonatal intensive care unit ,Bedside surgery ,Operative room ,Intrahospital transport ,Critically ill neonates ,Pediatrics ,RJ1-570 - Abstract
Abstract Introduction This is the report of the first official survey from the Italian Society of Pediatric Surgery (ISPS) to appraise the distribution and organization of bedside surgery in the neonatal intensive care units (NICU) in Italy. Methods A questionnaire requesting general data, staff data and workload data of the centers was developed and sent by means of an online cloud-based software instrument to all Italian pediatric surgery Units. Results The survey was answered by 34 (65%) out of 52 centers. NICU bedside surgery is reported in 81.8% of the pediatric surgery centers. A lower prevalence of bedside surgical practice in the NICU was reported for Southern Italy and the islands than for Northern Italy and Central Italy (Southern
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- 2020
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26. Clonal Spread of Hospital-Acquired NDM-1-Producing Klebsiella pneumoniae and Escherichia coli in an Italian Neonatal Surgery Unit: A Retrospective Study
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Marilena Agosta, Daniela Bencardino, Marta Argentieri, Laura Pansani, Annamaria Sisto, Marta Luisa Ciofi Degli Atti, Carmen D’Amore, Pietro Bagolan, Barbara Daniela Iacobelli, Mauro Magnani, Massimiliano Raponi, Carlo Federico Perno, Francesca Andreoni, and Paola Bernaschi
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Enterobacterales ,carbapenem-resistance ,neonates ,hospital-acquired colonization ,plasmid-typing ,sequence type ,Therapeutics. Pharmacology ,RM1-950 - Abstract
This article reports a rapid and unexpected spread of colonization cases of NDM-1 carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in a neonatal surgical unit (NSU) at Bambino Gesù Children’s Hospital in Rome, Italy. Between the 16th of November 2020 and the 18th of January 2021, a total of 20 NDM-1 carbapenemase-producing K. pneumoniae (n = 8) and E. coli (n = 12) were isolated from 17 out of 230 stool samples collected from neonates admitted in the aforementioned ward and time period by an active surveillance culture program routinely in place to monitor the prevalence of colonization/infection with multidrug-resistant Gram-negative microorganisms. All strains were characterized by antimicrobial susceptibility testing, detection of resistance determinants, PCR-based replicon typing (PBRT) and multilocus-sequence typing (MLST). All isolates were highly resistant to most of the tested antibiotics, and molecular characterization revealed that all of them harbored the blaNDM-1 gene. Overall, IncA/C was the most common Inc group (n = 20/20), followed by IncFIA (n = 17/20), IncFIIK (n = 14/20) and IncFII (n = 11/20). MLST analysis was performed on all 20 carbapenemase-producing Enterobacterales (CPE) strains, revealing three different Sequence Types (STs) among E. coli isolates, with the prevalence of ST131 (n = 10/12; 83%). Additionally, among the 8 K. pneumoniae strains we found 2 STs with the prevalence of ST37 (n = 7/8; 87.5%). Although patient results were positive for CPE colonization during their hospital stay, infection control interventions prevented their dissemination in the ward and no cases of infection were recorded in the same time period.
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- 2023
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27. Lung Ultrasound Score in Neonates with Congenital Diaphragmatic Hernia (CDH-LUS): A Cross-Sectional Study
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Chiara Maddaloni, Domenico Umberto De Rose, Sara Ronci, Iliana Bersani, Ludovica Martini, Stefano Caoci, Irma Capolupo, Andrea Conforti, Pietro Bagolan, Andrea Dotta, and Flaminia Calzolari
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LUS ,newborns ,ultrasonography ,congenital malformation ,Medicine (General) ,R5-920 - Abstract
Introduction: The use of a lung ultrasound (LUS) score has been described in the early phases of neonatal respiratory distress syndrome; however, there is still no data regarding the application of the LUS score to neonates with a congenital diaphragmatic hernia (CDH). The objective of this observational cross-sectional study was to explore, for the first time, the postnatal changes in LUS score patterns in neonates with CDH, with the creation of a new specific CDH-LUS score. Methods: We included all consecutive neonates with a prenatal diagnosis of CDH admitted to our Neonatal Intensive Care Unit (NICU) from June 2022 to December 2022 who underwent lung ultrasonography. Lung ultrasonography (LUS) was determined at scheduled time points: (T0) during the first 24 h of life; (T1) at 24–48 h of life; (T2) within 12 h of surgical repair; (T3) a week after the surgical repair. We used a modified LUS score (CDH-LUS), starting from the original 0–3 score. We assigned 4 as a score in the presence of herniated viscera in the hemithorax (liver, small bowel, stomach, or heart in the case of a mediastinal shift) in the preoperative scans or pleural effusions in the postoperative scans. Results: We included in this observational cross-sectional study 13 infants: twelve/13 had a left-sided hernia (2 severe, 3 moderate, and 7 mild cases), while one patient had a right-sided severe hernia. The median CDH-LUS score was 22 (IQR 16–28) during the first 24 h of life (T0), 21 (IQR 15–22) at 24–48 h of life (T1), 14 (IQR 12–18) within 12 h of surgical repair (T2) and 4 (IQR 2–15) a week after the surgical repair (T3). The CDH-LUS significantly dropped over time from the first 24 h of life (T0) to a week after the surgical repair (T3), according to ANOVA for repeated measures. Conclusion: We showed a significant improvement in CDH-LUS scores from the immediate postoperative period, with normal ultrasonographic evaluations a week after surgery in most patients.
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- 2023
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28. Development of a core outcome set for congenital pulmonary airway malformations: study protocol of an international Delphi survey
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René M H Wijnen, Maarten Schurink, Nagarajan Muthialu, Pietro Bagolan, Nazan Cobanoglu, Dhanya Mullassery, Holger Till, M. Singh, M. Boon, Sergei Hermelijn, Casper Kersten, Silvia Gartner, Carmen Mesas Burgos, Alberto Sgro, Stijn Heyman, Janne Suominen, Liesbeth Desender, Paul Losty, Kjetil Ertresvag, Harm A W M Tiddens, Marco Schnater, S.M. Hermelijn, C.M. Kersten, J.M. Schnater, R.M.H. Wijnen, H.A.W.M. Tiddens, S.C.M. Cochius, J. Suominen, M. Pakarinen, L. Martelius, S. Heyman, D. Vervloessem, H. Steyaert, A. Sgrò, P. Gamba, M. Schurink, S. van der Heide, J. Roukema, N. Rikkers-Mutsaerts, S. Terheggen-Lagro, S. de Beer, E. Haarman, H. Till, G. Singer, M. Metzelder, P Sezen, L. Desender, H. Schaballie, N. Cobanoglu, G. Gollu, M. Stanton, A. Bonnard, R. Sfeir, N. Muthialu, D. Mullassery, C. Wallis, D. Cox, P. Bagolan, F. Morini, C. Mesas Burgos, P. Conner, E. Caffrey Osvald, C. Bitkover, H. Decaluwé, M. Proesmans, J. Deprest, S. Gartner, A. Lain, P.D. Losty, I. Sinha, I. Yardley, L. Wessel, K. Zahn, T. Schaible, N. Qvist, M. Zampoli, G. Aksnes, C. K. van der Ent, K.M. Winter-de Groot, R. Peters, E. Hannon, Q. Jöbsis, and M. Bannier
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Medicine - Abstract
Introduction A worldwide lack of consensus exists on the optimal management of asymptomatic congenital pulmonary airway malformation (CPAM) even though the incidence is increasing. Either a surgical resection is performed or a wait-and-see policy is employed, depending on the treating physician. Management is largely based on expert opinion and scientific evidence is scarce. Wide variations in outcome measures are seen between studies making comparison difficult thus highlighting the lack of universal consensus in outcome measures as well. We aim to define a core outcome set which will include the most important core outcome parameters for paediatric patients with an asymptomatic CPAM.Methods and analysis This study will include a critical appraisal of the current literature followed by a three-stage Delphi process with two stakeholder groups. One surgical group including paediatric as well as thoracic surgeons, and a non-surgeon group including paediatric pulmonologists, intensive care and neonatal specialists. All participants will score outcome parameters according to their level of importance and the most important parameters will be determined by consensus.Ethics and dissemination Electronic informed consent will be obtained from all participants. Ethical approval is not required. After the core outcome set has been defined, we intend to design an international randomised controlled trial: the COllaborative Neonatal NEtwork for the first CPAM Trial, which will be aimed at determining the optimal management of patients with asymptomatic CPAM.
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- 2021
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29. Hyperspectral monitoring of a constructed wetland as a tertiary treatment in a wastewater treatment plant
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Chiavola, A., Bagolan, C., Moroni, M., and Bongirolami, S.
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- 2020
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30. An omic approach to congenital diaphragmatic hernia: a pilot study of genomic, microRNA, and metabolomic profiling
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Piersigilli, Fiammetta, Syed, Mansoor, Lam, TuKiet T., Dotta, Andrea, Massoud, Michela, Vernocchi, Pamela, Quagliariello, Andrea, Putignani, Lorenza, Auriti, Cinzia, Salvatori, Guglielmo, Bagolan, Pietro, and Bhandari, Vineet
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- 2020
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31. Case Report: Massive Intestinal Pneumatosis and Pneumoretroperitoneum Following Hematopoietic Stem Cell Transplantation in a 2-Year-Old Child
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Giorgia Contini, Arianna Bertocchini, Roberto Carta, Pietro Merli, Alessandro Inserra, Pietro Bagolan, and Francesco Morini
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hematopoietic stem cell transplantation ,intestinal pneumatosis ,graft versus host disease (GVHD) ,pneumomediastinum ,severe combined immunodeficiency ,Pediatrics ,RJ1-570 - Abstract
A 2-year-old boy with severe combined immunodeficiency (SCID) developed intestinal graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation (HSCT), associated with massive intestinal pneumatosis (IP), pneumoretroperitoneum (PRP), and pneumomediastinum. His fair clinical conditions allowed conservative management, with progressive normalization of imaging findings. The patient did not require surgery and is alive and in good clinical conditions at follow-up. In children with GVHD-related IP but good clinical conditions and no signs of peritonitis, IP is not a mandatory indication for surgery, despite its potentially striking imaging features. Conservative management, with intestinal rest, decompression, and antibiotics, often allows regression of the clinical picture.
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- 2021
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32. Assisted Reproductive Technology and Anorectal Malformation: A Single-Center Experience
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Chiara Iacusso, Barbara Daniela Iacobelli, Francesco Morini, Giorgia Totonelli, Milena Viggiano, Leonardo Caforio, and Pietro Bagolan
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anorectal malformation ,assisted reproductive techniques ,VACTERL ,congenital anomalies ,malformation anomalies ,Pediatrics ,RJ1-570 - Abstract
Background: Assisted reproductive technologies (ART) are becoming widespread, accounting for approximately 2% of all births in the western countries. Concerns exist on the potential association of ART with congenital anomalies. Few studies have addressed if a relationship exists between ART and the development of anorectal malformation (ARM). Our aim was to analyze the relationship between ARM and ART.Methods: Single-center retrospective case control study of all patients treated for ARM between 2010 and 2017. Patients with bronchiolitis treated since 2014 were used as controls. Variables analyzed include the following: prevalence of ART, gestational age, birth weight, and maternal age. Patients with ARM born after ART were also compared with those naturally conceived for disease complexity. Fisher's exact and Mann-Whitney U-tests were used as appropriate.Results: Three hundred sixty-nine patients were analyzed (143 cases and 226 controls). Prevalence of ART was significantly higher in ARM patients than in controls [7.6 vs. 3.0%; odds ratio: 2.59 (95% CI, 0.98–0.68); p = 0.05]. Among ARM patients, incidence of VACTERL association (17%) is more frequent in ART babies.Conclusion: Patients with ARM were more likely to be conceived following ART as compared with controls without congenital anomalies. Disease complexity of patients with ARM born after ART seems greater that those born after nonassisted conception.
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- 2021
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33. Operative Management of Neonatal Lymphatic Malformations: Lesson Learned From 57 Consecutive Cases
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Marianna Scuglia, Andrea Conforti, Laura Valfrè, Giorgia Totonelli, Chiara Iacusso, Barbara D. Iacobelli, Duino Meucci, Milena Viggiano, Fabio Fusaro, Andrea Diociaiuti, Francesco Morini, May El Hachem, and Pietro Bagolan
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lymphangioma ,respiratory distress ,neonates ,sclerotherapy ,OK432 sclerotherapy ,EXIT procedure ,Pediatrics ,RJ1-570 - Abstract
Aim of the study: Lymphatic malformations (LMs) are rare entities, sometimes difficult to treat, that may be life-threatening when intricately connected to airway structures. Invasive treatments are occasionally required, with sclerotherapy considered the treatment of choice and surgery as a second-line approach. The aim of the present study was to evaluate our multidisciplinary team experience in treating newborns affected by LMs requiring operative management, while defining early outcomes.Methods: Retrospective review of all consecutive patients admitted for LMs requiring operative management between January 2000 and January 2019. Patients were mainly characterized based on anatomical district of the LM (and further stratified based on the development of respiratory distress), need for tracheostomy, number of sclerotherapies, indication for surgery, and residual disease beyond the 1st year. Morbidity and mortality were also evaluated. Fisher exact test and Mann–Whitney test were used as appropriate. Statistical significance was set at p < 0.05.Results: Fifty-seven patients were included in the study, 36 with cervicofacial and/or mediastinal LMs and 21 with LMs of other anatomical districts. Due to the risk of developing respiratory distress at birth, patients with cervicofacial and/or mediastinal LMs were divided into two groups (8/36 group A vs. 28/36 group B). Group A patients are at higher risk for tracheostomy (7/8 group A vs. 1/28 group B, p = 0.0001) and more often require surgical reduction of the residual lymphatic abnormality (5/8 group A vs. 4/28 group B, p = 0.013). They also require sclerotherapies more often, but the difference is not statistically significant (8/8 group A vs. 19/28 group B, p = 0.15). Patients with cervicofacial/mediastinal LMs frequently suffer from persistent residual disease beyond the 1st year of life, significantly more often in group A (7/8 group A vs. 12/28 group B, p = 0.043).Conclusion: LMs are rare conditions with potential life-threatening behavior. Their intrinsic clinical complexity requires a multidisciplinary approach to the affected patients. Planning a long-term follow-up is essential because of the late-term problems those patients may experience.
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- 2021
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34. The Management of Asymptomatic Congenital Pulmonary Airway Malformation: Results of a European Delphi Survey
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Casper M. Kersten, Sergei M. Hermelijn, Dhanya Mullassery, Nagarajan Muthialu, Nazan Cobanoglu, Silvia Gartner, Pietro Bagolan, Carmen Mesas Burgos, Alberto Sgrò, Stijn Heyman, Holger Till, Janne Suominen, Maarten Schurink, Liesbeth Desender, Paul Losty, Henri Steyaert, Suzanne Terheggen-Lagro, Martin Metzelder, Arnaud Bonnard, Rony Sfeir, Michael Singh, Iain Yardley, Noor R. V. M. Rikkers-Mutsaerts, Cornelis K. van der Ent, Niels Qvist, Des W. Cox, Robert Peters, Michiel A. G. E. Bannier, Lucas Wessel, Marijke Proesmans, Michael Stanton, Edward Hannon, Marco Zampoli, Francesco Morini, Harm A. W. M. Tiddens, René M. H. Wijnen, and Johannes M. Schnater
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congenital lung abnormalities ,congenital pulmonary airway malformation ,core outcome set ,outcome parameters ,consensus ,Pediatrics ,RJ1-570 - Abstract
Consensus on the optimal management of asymptomatic congenital pulmonary airway malformation (CPAM) is lacking, and comparison between studies remains difficult due to a large variety in outcome measures. We aimed to define a core outcome set (COS) for pediatric patients with an asymptomatic CPAM. An online, three-round Delphi survey was conducted in two stakeholder groups of specialized caregivers (surgeons and non-surgeons) in various European centers. Proposed outcome parameters were scored according to level of importance, and the final COS was established through consensus. A total of 55 participants (33 surgeons, 22 non-surgeons) from 28 centers in 13 European countries completed the three rounds and rated 43 outcome parameters. The final COS comprises seven outcome parameters: respiratory insufficiency, surgical complications, mass effect/mediastinal shift (at three time-points) and multifocal disease (at two time-points). The seven outcome parameters included in the final COS reflect the diversity in priorities among this large group of European participants. However, we recommend the incorporation of these outcome parameters in the design of future studies, as they describe measurable and validated outcomes as well as the accepted age at measurement.
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- 2022
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35. The Role of Lung Function Testing in Newborn Infants With Congenital Thoracic Arterial Anomalies
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Claudia Columbo, Francesca Landolfo, Domenico Umberto De Rose, Anna Claudia Massolo, Aurelio Secinaro, Teresa Pia Santangelo, Marilena Trozzi, Cosimo Marco Campanale, Alessandra Toscano, Irma Capolupo, Pietro Bagolan, and Andrea Dotta
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pulmonary function tests ,infants ,vascular rings ,aortic arch ,thoracic arteries ,congenital tracheal stenosis ,Pediatrics ,RJ1-570 - Abstract
Introduction: Congenital thoracic arterial anomalies (CTAAs), such as complete or incomplete vascular rings, pulmonary artery sling, and innominate artery compression syndrome, may cause severe tracheomalacia and upper airway obstruction. An obstructive ventilatory pattern at lung function testing (LFT) has been suggested in the presence of CTAA. The severity of obstruction may be evaluated by LFT. Little is known about the use of LFT in newborn infants with CTAA. The aim of our study is to evaluate the role of LFT in CTAA diagnosis.Methods: This is a retrospective study, conducted between February 2016 and July 2020. All CTAA cases for whom LFT was performed preoperatively were considered for inclusion. Tidal volume (Vt), respiratory rate, and the ratio of time to reach the peak tidal expiratory flow over total expiratory time (tPTEF/tE) were assessed and compared to existing normative data. Demographics and CTAA characteristics were also collected.Results: Thirty cases were included. All infants with CTAA showed a significantly reduced Vt and tPTEF/tE, compared to existing normative data suggesting an obstructive pattern.No significant differences were found for LFT between cases with a tracheal obstruction
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- 2021
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36. Impact of the associated anorectal malformation on the outcome of spinal dysraphism after untethering surgery
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Totonelli, Giorgia, Messina, Raffaella, Morini, Francesco, Mosiello, Giovanni, Iacusso, Chiara, Randi, Franco, Palma, Paolo, Bagolan, Pietro, and Iacobelli, Barbara Daniela
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- 2019
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37. Diagnostic Workup of Neonates With Esophageal Atresia: Results From the EUPSA Esophageal Atresia Registry
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Francesco Morini, Andrea Conforti, Augusto Zani, Sanja Sindjic-Antunovic, Antti Koivusalo, Florian Friedmacher, Ernest van Heurn, Agostino Pierro, Michael Hollwarth, and Pietro Bagolan
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esophageal atresia ,registry analysis ,tracheobronchoscopy ,preoperative ,diagnostic work up ,Pediatrics ,RJ1-570 - Abstract
Aim: Controversies exist on the optimal diagnostic workup for neonates with esophageal atresia (EA) with/without tracheoesophageal fistula (TEF). Aim of this study was to describe the current diagnostic policies in EA/TEF patients enrolled in an International multicenter registry.Methods: All patients consecutively registered from July 2014 to December 2017 in the EUPSA Esophageal Atresia Registry (EUPSA-EAR) were included in the study. Data related to diagnostic investigations among Centers forming the EUPSA-EAR were analyzed.Main Results: During the study period, 374 consecutive patients were recorded by 23 Centers. The majority of patients underwent chest X-rays, echocardiography, abdominal ultrasound, and abdominal X-rays. Preoperative bronchoscopy and esophageal gap measurement were performed in one third of the patients.Conclusions: Present data from a large cohort of patients from the EUPSA-EAR show both inter-institutional and intra-institutional variability in diagnostic workup of patients with EA/TEF. Efforts should be made to develop guidelines on the diagnostic workup for EA/TEF patients.
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- 2020
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38. Gut Mucosal and Fecal Microbiota Profiling Combined to Intestinal Immune System in Neonates Affected by Intestinal Ischemic Injuries
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Lorenza Romani, Federica Del Chierico, Maria Chiriaco, Silvia Foligno, Sofia Reddel, Guglielmo Salvatori, Cristina Cifaldi, Simona Faraci, Andrea Finocchi, Paolo Rossi, Pietro Bagolan, Patrizia D'Argenio, Lorenza Putignani, and Fabio Fusaro
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intestinal ischemia ,mucosal microbiota ,fecal microbiota ,intestinal immune system ,microbial markers ,Microbiology ,QR1-502 - Abstract
Background and Purpose: Early life microbiota plays a crucial role in human health by acting as a barrier from pathogens' invasion and maintaining the intestinal immune homoeostasis. Altered fecal microbiota (FM) ecology was reported in newborns affected by intestinal ischemia. Our purpose was to describe, in these patients, the FM, the mucosal microbiota (MM) and the mucosal immunity.Methods: Fourteen newborns underwent intestinal resection because of intestinal ischemia. FM and MM were determined through targeted-metagenomics, diversity assignment and Kruskal-Wallis analyses of Operational taxonomic units (OTUs). The mucosal immune cells were analyzed through cytofluorimetry.Results and Conclusion: Based on the severity intestinal injueris we identified two groups: extensive (EII) and focal intestinal ischemia (FII). FM and MM varied in EII and FII groups, showing in the EII group the predominance of Proteobacteria and Enterobacteriaceae and the reduction of Bacteroidetes and Verrucomicrobia for both microbiota. The MM was characterized by a statistically significant reduction of Bacteroides, Lachnospiraceae and Ruminococcaceae and by a higher diversity in the EII compared to FII group. FM showed a prevalence of Proteobacteria, while the Shannon index was lower in the EII compared to FII group. An overall increment in B- and T-lymphocytes and Natural killer (NK) T-like cells was found for EII mucosal samples associated to an increment of TNF-α and INF-γ expressing cells, compared to FII group. FM and MM carry specific signatures of intestinal ischemic lesions. Further research may be crucial to address the role of specific taxa in EII, expecially with reference to inflammation grade and ischemia extension.
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- 2020
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39. Lack of Gut Secretory Immunoglobulin A in Memory B-Cell Dysfunction-Associated Disorders: A Possible Gut-Spleen Axis
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Rita Carsetti, Antonio Di Sabatino, Maria Manuela Rosado, Simona Cascioli, Eva Piano Mortari, Cinzia Milito, Ola Grimsholm, Alaitz Aranburu, Ezio Giorda, Francesco Paolo Tinozzi, Federica Pulvirenti, Giuseppe Donato, Francesco Morini, Pietro Bagolan, Gino Roberto Corazza, and Isabella Quinti
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common variable immune deficiency ,gut mucosal immunology ,plasma cell ,splenectomy ,transmembrane activator and calcium-modulator and cyclophilin ligand interactor ,Immunologic diseases. Allergy ,RC581-607 - Abstract
Background: B-1a B cells and gut secretory IgA (SIgA) are absent in asplenic mice. Human immunoglobulin M (IgM) memory B cells, which are functionally equivalent to mouse B-1a B cells, are reduced after splenectomy.Objective: To demonstrate whether IgM memory B cells are necessary for generating IgA-secreting plasma cells in the human gut.Methods: We studied intestinal SIgA in two disorders sharing the IgM memory B cell defect, namely asplenia, and common variable immune deficiency (CVID).Results: Splenectomy was associated with reduced circulating IgM memory B cells and disappearance of intestinal IgA-secreting plasma cells. CVID patients with reduced circulating IgM memory B cells had a reduced frequency of gut IgA+ plasma cells and a disrupted film of SIgA on epithelial cells. Toll-like receptor 9 (TLR9) and transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI) induced IgM memory B cell differentiation into IgA+ plasma cells in vitro. In the human gut, TACI-expressing IgM memory B cells were localized under the epithelial cell layer where the TACI ligand a proliferation inducing ligand (APRIL) was extremely abundant.Conclusions: Circulating IgM memory B cell depletion was associated with a defect of intestinal IgA-secreting plasma cells in asplenia and CVID. The observation that IgM memory B cells have a distinctive role in mucosal protection suggests the existence of a functional gut-spleen axis.
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- 2020
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40. Prevalence and Molecular Typing of Carbapenemase-Producing Enterobacterales among Newborn Patients in Italy
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Marilena Agosta, Daniela Bencardino, Marta Argentieri, Laura Pansani, Annamaria Sisto, Marta Luisa Ciofi Degli Atti, Carmen D’Amore, Lorenza Putignani, Pietro Bagolan, Barbara Daniela Iacobelli, Andrea Dotta, Ludovica Martini, Luca Di Chiara, Mauro Magnani, Carlo Federico Perno, Francesca Andreoni, and Paola Bernaschi
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Enterobacterales ,carbapenem resistance ,neonates ,plasmid-typing ,sequence type ,Therapeutics. Pharmacology ,RM1-950 - Abstract
The spread of carbapenemase-producing Enterobacterales (CPE), especially Klebsiella pneumoniae (K. pneumoniae) and Escherichia coli (E. coli), is a serious public health threat in pediatric hospitals. The associated risk in newborns is due to their underdeveloped immune system and limited treatment options. The aim was to estimate the prevalence and circulation of CPE among the neonatal intensive units of a major pediatric hospital in Italy and to investigate their molecular features. A total of 124 CPE were isolated from rectal swabs of 99 newborn patients at Bambino Gesù Children’s Hospital between July 2016 and December 2019. All strains were characterized by antimicrobial susceptibility testing, detection of resistance genes, and PCR-based replicon typing (PBRT). One strain for each PBRT profile of K. pneumoniae or E. coli was characterized by multilocus-sequence typing (MLST). Interestingly, the majority of strains were multidrug-resistant and carried the blaNDM gene. A large part was characterized by a multireplicon status, and FII, A/C, FIA (15%) was the predominant. Despite the limited size of collection, MLST analysis revealed a high number of Sequence Types (STs): 14 STs among 28 K. pneumoniae and 8 STs among 11 E. coli, with the prevalence of the well-known clones ST307 and ST131, respectively. This issue indicated that some strains shared the same circulating clone. We identified a novel, so far never described, ST named ST10555, found in one E. coli strain. Our investigation showed a high heterogeneity of CPE circulating among neonatal units, confirming the need to monitor their dissemination in the hospital also through molecular methods.
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- 2022
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41. The experience of breastfeeding infants affected by congenital diaphragmatic hernia or esophageal atresia
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G Salvatori, S Foligno, M Massoud, F Piersigilli, P Bagolan, and A Dotta
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Breastfeeding ,Breast milk (BM) ,Congenital diaphragmatic hernia (CDH) ,Esophageal atresia (EA) ,Human milk ,Neonatal surgery unit (NSU), kangaroo mother care (KMC) ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Newborns with congenital diaphragmatic hernia (CDH) and esophageal atresia (EA) might experience breastfeeding difficulties. The aim of this study was to detect the prevalence of breastfeeding in newborns with CDH and EA at different time points. Methods We performed an epidemiological study and retrospective survey on the prevalence of breastfeeding in CDH and EA affected newborns. We identified 40 CDH and 25 EA newborns who were fed through breastfeeding procedures according to WHO categorized definitions, and compared the breastfeeding procedures at the beginning of hospitalization and at three months of life. Results Although all the mothers attempted breastfeeding after birth, only 44 (67.7%) were still breastfeeding at the time of discharge. Exclusive breastfeeding was successful for only 19 (29%) mothers. The rate of exclusive breastfeeding at three months of life did not differ statistically from discharge and between the two groups of study. Conclusion A large percentage of mothers of children with CDH and EA who breastfed at the beginning of hospitalization did not continue at three months. It would be important to increase the breastfeeding rate in CDH and EA affected newborns by following specific steps for vulnerable infants and sustaining breastfeeding after discharge.
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- 2018
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42. Giant rapidly involuting congenital hemangioma and Kasabach‐Merritt phenomenon: A potentially underhanded trap
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Diociaiuti, A., primary, Bersani, I., additional, Dotta, A., additional, Braguglia, A., additional, Di Pede, A., additional, Iacobelli, B. D., additional, Pugnaloni, F., additional, Guido, M., additional, Di Fabio, S., additional, Toscano, A., additional, Conforti, A., additional, Bagolan, P., additional, and Hachem, El, additional
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- 2023
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43. Bedside surgery in the newborn infants: survey of the Italian society of pediatric surgery
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Pelizzo, Gloria, Bagolan, Pietro, Morini, Francesco, Aceti, Mariagrazia, Alberti, Daniele, Andermarcher, Mario, Avolio, Luigi, Bartoli, Fabio, Briganti, Vito, Cacciaguerra, Sebastiano, Camoglio, Francesco S., Ceccarelli, Pierluca, Cheli, Maurizio, Chiarenza, Fabio, Ciardini, Enrico, Cimador, Marcello, Clemente, Ennio, Cozzi, Denis A., Dall’ Oglio, Luigi, De Luca, Ugo, Del Rossi, Carmine, Esposito, Ciro, Falchetti, Diego, Federici, Silvana, Gamba, Piergiorgio, Gentilino, Valerio, Mattioli, Girolamo, Martino, Ascanio, Messina, Mario, Noccioli, Bruno, Inserra, Alessandro, Lelli Chiesa, Pierluigi, Leva, Ernesto, Licciardi, Francesco, Midrio, Paola, Nobili, Maria, Papparella, Alfonso, Paradies, Guglielmo, Piazza, Giuseppe, Pini Prato, Alessio, Rossi, Fabio, Riccipetitoni, Giovanna, Romeo, Carmelo, Salerno, Domenico, Settimi, Alessandro, Schleef, Jurgen, Milazzo, Mario, Calcaterra, Valeria, and Lima, Mario
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- 2020
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44. Tethered cord in patients affected by anorectal malformations: a survey from the ARM-Net Consortium
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Fanjul, María, Samuk, I., Bagolan, P., Leva, E., Sloots, C., Giné, C., Aminoff, D., Midrio, P., Aminoff, Dalia, Bagolan, Piero, De Blaauw, Ivo, Deluggi, Stefan, Fanjul, María, Fascetti Leon, Francesco, García, Araceli, Giné, Carles, Giuliani, Stefano, Grano, Caterina, Grasshoff-Derr, Sabine, Haanen, Michel, Holland-Cunz, Stephan, Jenetzky, Ekkehart, Lacher, Martin, Leva, Ernesto, Lisi, Grabiele, Makedonsky, Igor, Marcelis, Carlos, Midrio, Paola, Miserez, Marc, Ozen, Onur, Percin, Ferda, Reutter, Heiko, Rohleder, Stephan, Samuk, Inbal, Schmiedeke, Eberhard, Schwarzer, Nicole, Sloots, Pim, Stenström, Pernilla, Till, Holger, Van der Steeg, Lideke, Van Rooij, Iris, Volk, Patrick, Wester, Tomas, Zwink, Nadine, and On behalf of the ARM-Net Consortium
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- 2017
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45. Respiratory problems in children with esophageal atresia and tracheoesophageal fistula
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Federica Porcaro, Laura Valfré, Lelia Rotondi Aufiero, Luigi Dall’Oglio, Paola De Angelis, Alberto Villani, Pietro Bagolan, Sergio Bottero, and Renato Cutrera
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Congenital malformations ,Esophageal atresia ,Tracheoesophageal fistula ,Respiratory symptoms ,Flexible bronchoscopy ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Children with congenital esophageal atresia (EA) and tracheoesophageal fistula (TEF) have chronic respiratory symptoms including recurrent pneumonia, wheezing and persistent cough. The aim of this study is to describe the clinical findings of a large group of children with EA and TEF surgically corrected and the instrumental investigation to which they have undergone in order to better understand the patient’s needs and harmonize the care. Methods A retrospective data collection was performed on 105 children with EA and TEF followed at Department of Pediatric Medicine of Bambino Gesù Children’s Hospital (Rome, Italy) between 2010 and 2015. Results 69/105 (66%) children reported lower respiratory symptoms with a mean age onset of 2.2 ± 2.5 years and only 63/69 (91%) performed specialist assessment at Respiratory Unit. Recurrent pneumonia (33%) and wheezing (31%) were the most reported symptoms. The first respiratory evaluation was performed after surgically correction of gastroesophageal reflux (GER) at mean age of 3.9 ± 4.2 years. Twenty nine patients have undergone to chest CT with contrast enhancement detecting localized atelectasis (41%), residual tracheal diverticulum (34%), bronchiectasis (31%), tracheal vascular compression (21%), tracheomalacia (17%) and esophageal diverticulum (14%). Fifty three patients have undergone to airways endoscopy detecting tracheomalacia (66%), residual tracheal diverticulum (26%), recurrent tracheoesophageal fistula (19%) and vocal cord paralysis (11%). Conclusions Our study confirms that respiratory symptoms often complicate EA and TEF; their persistence despite medical and surgical treatment of GER means that other etiological hypothesis must be examined and that a complete respiratory diagnostic work up must be considered.
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- 2017
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46. Using IOTA terminology to evaluate fetal ovarian cysts: analysis of 51 cysts over 10-year period
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Romiti, A, Moro, Francesca, Ricci, Luigia, Codeca, C, Pozzati, Federica, Viggiano, M, Vicario, R, Fabietti, I, Scambia, Giovanni, Bagolan, P, Testa, Antonia Carla, Caforio, Leonardo, Moro, F, Ricci, L, Pozzati, F, Scambia, G (ORCID:0000-0003-2758-1063), Testa, A C (ORCID:0000-0003-2217-8726), Caforio, L (ORCID:0000-0002-1677-695X), Romiti, A, Moro, Francesca, Ricci, Luigia, Codeca, C, Pozzati, Federica, Viggiano, M, Vicario, R, Fabietti, I, Scambia, Giovanni, Bagolan, P, Testa, Antonia Carla, Caforio, Leonardo, Moro, F, Ricci, L, Pozzati, F, Scambia, G (ORCID:0000-0003-2758-1063), Testa, A C (ORCID:0000-0003-2217-8726), and Caforio, L (ORCID:0000-0002-1677-695X)
- Abstract
ObjectivesTo describe ultrasound features of fetal ovarian cysts as reported by the original ultrasound examiner, to apply International Ovarian Tumor Analysis (IOTA) terminology after retrospective analysis of the images and to describe patient management and evolution of fetal cysts during pregnancy and after delivery. MethodsThis retrospective observational study included pregnant women diagnosed on ultrasound examination with a fetal ovarian cyst at the Prenatal Diagnosis Division of the Bambino Gesu Children's Hospital, in Rome, between March 2011 and May 2020. Cysts were classified by the original ultrasound examiner as 'simple' (unilocular anechoic cyst) or 'complex' (cyst with other morphology). In addition, three ultrasound examiners, experienced in gynecologic ultrasound, classified retrospectively the fetal ovarian cysts according to IOTA terminology, by reviewing stored ultrasound images. The evolution of these fetal ovarian cysts during pregnancy and after birth was recorded. ResultsIncluded were 51 ovarian cysts in 48 fetuses. Of the 51 cysts, 29 (56.9%) had been classified by the original ultrasound examiner as 'simple', and 22 (43.1%) as 'complex'. Of the simple cysts, the majority (20/29 (69.0%)) resolved spontaneously after delivery, 2/29 (6.9%) resolved following intrauterine aspiration, 2/29 (6.9%) resolved after postnatal aspiration and 5/29 (17.2%) underwent surgery due to persistence after delivery; in all five, normal ovarian parenchyma without signs of necrosis was observed at histology. Of the complex cysts, 7/22 (31.8%) resolved spontaneously. The other 15/22 (68.2%) were removed surgically and, at histology, necrosis was observed in most (12/15 (80.0%)), while a benign epithelial cyst with normal ovarian parenchyma was observed in 3/15 (20%). After reviewing the ultrasound images and applying IOTA terminology, all 51 (100%) fetal cysts were described as unilocular; 29/51 (56.9%) cysts showed anechoic content (described as simple cysts by
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- 2023
47. Guidelines of the Italian Society of Videosurgery in Infancy for the minimally invasive treatment of the ureteropelvic-junction obstruction
- Author
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Salvatore Fabio Chiarenza, Cosimo Bleve, Ciro Esposito, Maria Escolino, Fabio Beretta, Maurizio Cheli, Vincenzo Di Benedetto, Maria Grazia Scuderi, Giovanni Casadio, Maurizio Marzaro, Leon Francesco Facetti, Pietro Bagolan, Claudio Vella, Maria Luisa Conighi, Daniela Codric, Simona Nappo, and Paolo Caione
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SIVI ,minimally intensive treatment ,ureteropelvic-junction obstruction ,Pediatrics ,RJ1-570 ,Surgery ,RD1-811 - Abstract
The hydronephrosis, characterized by the dilation of the renal pelvicalyceal system with possible functional damage to the renal parenchyma, is the most common congenital abnormality of the urinary system detected in utero through the prenatal ultrasound screening. (...)
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- 2019
- Full Text
- View/download PDF
48. Guidelines of the Italian Society of Videosurgery in Infancy for the minimally invasive treatment of the esophageal atresia
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Salvatore Fabio Chiarenza, Maria Luisa Conighi, Ciro Esposito, Maria Escolino, Fabio Beretta, Maurizio Cheli, Vincenzo Di Benedetto, Maria Grazia Scuderi, Giovanni Casadio, Maurizio Marzaro, Leon Francesco Fascetti, Andrea Conforti, Pietro Bagolan, Claudio Vella, Cosimo Bleve, Daniela Codric, and Paolo Caione
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SIVI ,minimally intensive treatment ,esophageal atresia ,Pediatrics ,RJ1-570 ,Surgery ,RD1-811 - Abstract
Esophageal Atresia (EA) is defined as an interruption in esophageal continuity that results in a proximal tract that ends in a blind pouch in 98% of cases, and a distal tract that in 87% of cases arises via a Fistula from the Trachea (TEF). (...).
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- 2019
- Full Text
- View/download PDF
49. Guidelines of the Italian Society of Videosurgery in Infancy for the minimally invasive treatment of pediatric nephrectomy and partial nephrectomy
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Salvatore Fabio Chiarenza, Cosimo Bleve, Ciro Esposito, Maria Escolino, Fabio Beretta, Maurizio Cheli, Vincenzo Di Benedetto, Maria Grazia Scuderi, Giovanni Casadio, Maurizio Marzaro, Leon Francesco Fascetti, Pietro Bagolan, Caludio Vella, Maria Luisa Conighi, Daniela Codric, Simona Nappo, and Paolo Caione
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SIVI ,minimally invasive treatment ,pediatric nephrectomy ,pediatric partial nephrectomy ,Pediatrics ,RJ1-570 ,Surgery ,RD1-811 - Abstract
Throughout history, the pediatric laparoscopic nephrectomy was first described at the beginning of the Nineties by Erlich and colleagues in a child and by Koyle and colleagues in an unweaned patient. (...)
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- 2019
- Full Text
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50. The CoDiNOS trial protocol: an international randomised controlled trial of intravenous sildenafil versus inhaled nitric oxide for the treatment of pulmonary hypertension in neonates with congenital diaphragmatic hernia
- Author
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Anne Greenough, Thomas Schaible, Neil Patel, Dick Tibboel, Arno van Heijst, Theodore Dassios, Joost van Rosmalen, Viviana Arreo, Yogen Singh, Karel Allegaert, Suzan Cochius-den Otter, Florian Kipfmueller, Maria Dolores Elorza, Ana Sanchez, Leopoldo Martinez, Carlos Labrandero, Pertierra Cortada, Jordi Clotet Caba, Marta Aguar, Ana Gimeno, Raquel Escrig, Irma Capolupo, Pietro Bagolan, Fabrizio Ciralli, Genny Raffaeli, Giacomo Cavallaro, Valentina Condò, Paul D. Losty, Marie Horan, Nimish V. Subhedar, Emma E. Williams, Jennifer B. Brandt, Alexandra Kreissl, Berndt Urlesberger, Carmen Mesas Burgos, Björn Frenckner, Björn Larrson, Carla Pinto, Joana Saldaha, Anne Debeer, Anne Smits, Ragnhild Emblem, Richard Keijzer, Yassar Elsayed, David Tingay, and Ulrike Kraemer
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Medicine - Abstract
Introduction Congenital diaphragmatic hernia (CDH) is a developmental defect of the diaphragm that impairs normal lung development, causing pulmonary hypertension (PH). PH in CDH newborns is the main determinant for morbidity and mortality. Different therapies are still mainly based on ‘trial and error’. Inhaled nitric oxide (iNO) is often the drug of first choice. However, iNO does not seem to improve mortality. Intravenous sildenafil has reduced mortality in newborns with PH without CDH, but prospective data in CDH patients are lacking.Methods and analysis In an open label, multicentre, international randomised controlled trial in Europe, Canada and Australia, 330 newborns with CDH and PH are recruited over a 4-year period (2018–2022). Patients are randomised for intravenous sildenafil or iNO. Sildenafil is given in a loading dose of 0.4 mg/kg in 3 hours; followed by continuous infusion of 1.6 mg/kg/day, iNO is dosed at 20 ppm. Primary outcome is absence of PH on day 14 without pulmonary vasodilator therapy and/or absence of death within the first 28 days of life. Secondary outcome measures include clinical and echocardiographic markers of PH in the first year of life. We hypothesise that sildenafil gives a 25% reduction in the primary outcome from 68% to 48% on day 14, for which a sample size of 330 patients is needed. An intention-to-treat analysis will be performed. A p-value (two-sided)
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- 2019
- Full Text
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