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OBJECTIVE: This study aimed to quantitatively analyze the calculi components of upper urinary tract calculi and to explore the relationship between calculus components, demographic characteristics, and underlying diseases. PATIENTS AND METHODS: Clinical data of 1,495 patients with upper urinary tract calculi were retrospectively collected. The calculi were divided into simple calcium oxalate, calcium oxalate mixed, calcium phosphate mixed, uric acid, magnesium ammonium phosphate, and other components. Statistical software SPSS 22.0 was used to analyze the differences between the stone compositions and various factors. The influencing factors (p < 0.05) were analyzed using multiple logistic regression analysis. RESULTS: Among 1,495 patients with upper urinary tract calculi, simple calcium oxalate calculi were the most common component (39.7%), followed by calcium oxalate mixed calculi (30.4%), uric acid calculi (13.6%), calcium phosphate mixed calculi (10.4%), magnesium ammonium phosphate calculi (5.8%) and other component calculi (0.1%). Univariate analysis revealed statistically significant differences in stone composition according to gender, age, and hyperuricemia (p < 0.05). Multiple logistic regression analysis showed that compared to men, the odds ratio (OR) values of calcium oxalate mixed stones, calcium phosphate mixed stones, and magnesium ammonium phosphate stones in women were 1.61, 2.50, and 4.17, respectively (p < 0.001). Compared with elderly patients, the OR values of calcium phosphate mixed stones in young and middle-aged patients were 3.14 and 2.70, respectively (p < 0.05). CONCLUSIONS: Patients with different stone components had different demographic characteristics, and stone components were significantly different between gender and age. Calcium oxalate mixed stones were more common in females, and calcium phosphate mixed stones and magnesium ammonium phosphate stones were more common in females, young patients, and middle-aged patients. [ABSTRACT FROM AUTHOR]

The angular distributions of 12C + 90,92,94,96Zr elastic scattering were measured with the Q3D magnetic spectrometer at the HI-13 tandem accelerator, Beijing. The real part of optical potential were extracted by analysing these angular distributions. The analysis enable us to avoid the influence of Coulomb effect and to observe the dependence of optical potential on the nuclear properties. With the deduced potential parameters, the experimental elastic scattering angular distributions can be reproduced very well. Formulas to infer global heavy-ion potential parameters were obtained then by analyzing the extracted optical potential parameters. The formulas can be used widely in heavy-ion nuclear reactions.

The proton decay of53Com(3174.1 keV, 19/2-) was investigated via the fragmentation of a 58Ni primary beam. The proton-decay energy was determined with an improved precision to be 1558(8) keV. With this new result and the mass of 53Com, the 52Fe mass excess was derived to be - 48330(8)keV, which is in good agreement with the AMEI2 value. A new recommended value of - 48331.6(49) keV is given. [ABSTRACT FROM AUTHOR]

The angular distributions of the 12C(11B,11B)12C and 12C(11B,12C)11B reactions have been measured at an incident energy of 50 MeV by using the high resolution Q3D magnetic spectrometer of the HI-13 tandem accelerator at China Institute of Atomic Energy, Beijing. The optical potential parameters of the 11B + 12C system are determined by fitting the angular distribution of the elastic scattering and then used to predict the cross sections of the elastic transfer reaction leading to the ground state in l 2C based on distorted-wave Born approximation (DWBA) analysis. Taking into account the interference between the elastic scattering and the elastic transfer processes, the proton spectroscopic factor of the, 12C ground state is extracted to be 2.15 ± 0.23 by constraining the geometrical parameters r0 and a using the rms radius of the valence proton in the 12C ground state. [ABSTRACT FROM AUTHOR]

The relative γ-decay probability ratios of the neutron resonance states in 94Zr and 92Zr populated via two-neutron transfer reactions, 92Zr(18O,16O)94Zr and 90Zr(18O,16O)92Zr, have been measured to test the validity of the surrogate ratio method (SRM) in determining the (n, γ) reaction cross section. The cross sections of the 93Zr(n,γ)94Zr reaction are derived from the experimentally obtained ratios and the cross sections of the 91Zr(n,γ)92Zr reaction in the equivalent neutron energy range of En=0-8MeV. The deduced cross sections of 93Zr(n,γ)94Zr reaction agree with the directly measured ones in the low-energy region, and with the evaluated ENDF/B-VII.1 data at higher energies of En>3MeV. The agreement supports the concept of the SRM method to indirectly determine the (n,γ) reaction cross sections. [ABSTRACT FROM AUTHOR]

Objective: To analyze the ultrasonic manifestations, clinical features, high risk factors and key points of pregnancy management in prenatal diagnosis of umbilical artery thrombosis (UAT). Methods: The data of 31 pregnant women of UAT diagnosed by prenatal ultrasonography and confirmed after birth from July 2017 to July 2022 at the Women's Hospital, Zhejiang University School of Medicine were retrospectively analyzed, including the maternal characteristics, pregnancy outcomes and fetal complications. In addition, the baseline data and pregnancy outcomes were compared in 21 patients who continued pregnancy after diagnosis of UAT. Of the 21 UAT cases that continued pregnancy, 10 cases were treated with low molecular weight heparin (LMWH; LMWH treatment group), while the other 11 patients had expectant treatment(expectant treatment group). Results: The age of the 31 pregnant women was (30.2±4.7) years, of which 5 cases (16%,5/31) were advanced age pregnant women. The gestational age at diagnosis was (32.9±4.0) weeks, and the gestational age at termination of pregnancy was (35.6±2.9) weeks. In 31 fetuses with UAT, 15 cases (48%) had fetal distress, 11 cases (35%) had fetal growth restriction, and 3 cases (10%) had intrauterine stillbirth. There were 28 cases of live births, including 26 cases by cesarean section and 2 cases by vaginal delivery. There were also 3 stillbirths, all delivered vaginally. Four neonates had mild asphyxia and two newborns had severe asphyxia. Among the 31 cases, 10 cases were terminated immediately after diagnosis, the gestational age at diagnosis was (35.9±2.9) weeks. Another 21 pregnancies continued, and their gestational age at diagnosis was (31.4±3.7) weeks. The median prolonged gestational age in LMWH treatment group was 7.9 weeks (4.6-9.4 weeks), and all were live births. The median prolonged gestational age in the expectant treatment group was 0.6 weeks (0.0-1.0 weeks), and 2 cases were stillbirths. There was a statistically significant difference in prolonged gestational age ( P =0.002). Conclusions: Ultrasound is the preferred method for prenatal detection of UAT. Clinicians need to be vigilant for UAT when a newly identified single umbilical artery is detected by ultrasound in the second or third trimesters. The decision to continue or terminate the pregnancy depends on the gestational age and the condition of fetus. Attention should be paid to fetal movements as the pregnancy continues. The treatment of LMWH as soon as possible after diagnosis of UAT may improve the pregnancy outcome.

Objective: To investigate the effect of apoptosis-associated protein kinase-like 1 (DAPL1) hypomethylation on prognosis of lung cancer patients with epidermal growth factor receptor gene exon 19 deletion (EGFR Del19) mutation. Methods: The clinicopathological data of lung cancer patients in databases of genomic data sharing (GDC) TCGA lung adenocarcinoma, TCGA lung adenocarcinoma, and TCGA lung cancer were collected to analyze the effect of DAPL1 methylation level on the prognosis of patients with EGFR Del19 mutation. Linear regression model was used for correlation analysis, Kaplan-Meier method was used to draw the survival curve, and the difference of survival curve between the two groups was tested by Log rank. Results: In GDC TCGA lung adenocarcinoma, TCGA lung adenocarcinoma and TCGA lung cancer databases, the 5-year survival rates of lung cancer patients with high DAPL1 expression (31.9%, 27.5% and 33.0%, respectively) were higher than those with low DAPL1 expression (11.0%, 11.6% and 13.8%, respectively). The differences were statistically significant ( P =0.006, 0.028 and 0.025, respectively). The median expression levels of DAPL1 in patients with EGFR Del19 mutation (12.8, 2.75 and 2.9, respectively) were higher than those in patients with other EGFR mutations (11.6, 1.75 and 1.8, respectively, P <0.05). In TCGA lung adenocarcinoma and TCGA lung cancer database, the 5-year survival rate of lung cancer patients with lower DAPL1 methylation levels (22.4% and 16.4%, respectively) were higher than those of lung cancer patients with higher DAPL1 methylation levels (15.1% and 14.2%, respectively), with statistical significance ( P <0.05). The expression level of DAPL1 was positively correlated with the EGFR mutant subtype ( r =0.909, P <0.05), and negatively correlated with DNA methylation ( r =-0.891, P <0.05). The expression of DAPL1 in lung cancer patients was regulated by DNA methylation, which affected the prognosis of lung cancer patients. Conclusion: High DAPL1 expression, or hypomethylation, is associated with lung cancer EGFR Del19 mutation subtype, and DAPL1 hypomethylated lung cancer patients have longer overall survival.