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31 results on '"Bartolacci, Caterina"'

2. Author Correction: Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer

Author

Bartolacci, Caterina, Andreani, Cristina, Vale, Gonçalo, Berto, Stefano, Melegari, Margherita, Crouch, Anna Colleen, Baluya, Dodge L., Kemble, George, Hodges, Kurt, Starrett, Jacqueline, Politi, Katerina, Starnes, Sandra L., Lorenzini, Daniele, Raso, Maria Gabriela, Solis Soto, Luisa M., Behrens, Carmen, Kadara, Humam, Gao, Boning, Wistuba, Ignacio I., Minna, John D., McDonald, Jeffrey G., and Scaglioni, Pier Paolo

Published
2022
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3. Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer

Author

Bartolacci, Caterina, Andreani, Cristina, Vale, Gonçalo, Berto, Stefano, Melegari, Margherita, Crouch, Anna Colleen, Baluya, Dodge L., Kemble, George, Hodges, Kurt, Starrett, Jacqueline, Politi, Katerina, Starnes, Sandra L., Lorenzini, Daniele, Raso, Maria Gabriela, Solis Soto, Luisa M., Behrens, Carmen, Kadara, Humam, Gao, Boning, Wistuba, Ignacio I., Minna, John D., McDonald, Jeffrey G., and Scaglioni, Pier Paolo

Published
2022
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4. Anticancer Activity of Imidazolyl Gold(I/III) Compounds in Non-Small Cell Lung Cancer Cell Lines.

Author

Galassi, Rossana, Sargentoni, Nicola, Renzi, Sofia, Luciani, Lorenzo, Bartolacci, Caterina, Pattabhi, Prasad, Andreani, Cristina, and Pucciarelli, Stefania

Subjects
NON-small-cell lung carcinoma, CANCER cell growth, TETRAHYDROFOLATE dehydrogenase, GOLD compounds, LUNG cancer
Abstract

Lung cancer is a leading cause of cancer-related death worldwide that needs updated therapies to contrast both the serious side effects and the occurrence of drug resistance. A panel of non-small cell lung cancer (NSCLC) cells were herein employed as cancer models. Eight structurally related gold(I) and gold(III) complexes with NHC and halides or triphenylphosphane ligands were investigated as lung cancer cell growth inhibitors. As expected, gold compounds with PPh3 were found to be more cytotoxic than homoleptic [(NHC)2-Au(I)]X or heteroleptic NHC-Au(I)X or NHC-Au(III)X3 complexes. Mixed ligand gold(I) compounds exhibiting the linear NHC-AuPPh3 (compound 7) or the trigonal NHC-Au(Cl)PPh3 (compound 8) arrangements at the central metal were found to be the best lung cancer cytotoxic compounds. Analysis of the TrxR residual activity of the treated cells revealed that these compounds efficiently inhibit the most accredited molecular target for gold compounds, the TrxR, with compound 8 reaching more than 80% activity reduction in lung cells. Some of the current cancer lung therapy protocols consist of specific lung cancer cell cytotoxic agents combined with antifolate drugs; interestingly, the herein gold compounds are both TrxR and antifolate inhibitors. The human DHFR was inhibited with IC50 ranging between 10–21 µM, depending on substrate concentrations, proceeding by a likely allosteric mechanism only for compound 8. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Copper drives remodeling of metabolic state and progression of clear cell renal cell carcinoma

Author

Czyzyk-Krzeska, Maria, primary, Bischoff, Megan E, additional, Shamsaei, Behrouz, additional, Yang, Juechen, additional, Secic, Dina, additional, Vemuri, Bhargav, additional, Reisz, Julie A, additional, D'Alessandro, Angelo, additional, Bartolacci, Caterina, additional, Adamczyk, Rafal, additional, Schmidt, Lucas, additional, Wang, Jiang, additional, Martines, Amelia, additional, Biesiada, Jacek, additional, Vest, Katherine E, additional, Scaglioni, Pier Paolo, additional, Plas, David R, additional, Patra, Krushna C, additional, Gulati, Shuchi, additional, Figueroa, Julio Landero, additional, Meller, Jarek, additional, and Cunningham, J. Tom, additional

Published
2024
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9. Data from Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma

Author

Puca, Francesca, primary, Yu, Fei, primary, Bartolacci, Caterina, primary, Pettazzoni, Piergiorgio, primary, Carugo, Alessandro, primary, Huang-Hobbs, Emmet, primary, Liu, Jintan, primary, Zanca, Ciro, primary, Carbone, Federica, primary, Del Poggetto, Edoardo, primary, Gumin, Joy, primary, Dasgupta, Pushan, primary, Seth, Sahil, primary, Srinivasan, Sanjana, primary, Lang, Frederick F., primary, Sulman, Erik P., primary, Lorenzi, Philip L., primary, Tan, Lin, primary, Shan, Mengrou, primary, Tolstyka, Zachary P., primary, Kachman, Maureen, primary, Zhang, Li, primary, Gao, Sisi, primary, Deem, Angela K., primary, Genovese, Giannicola, primary, Scaglioni, Pier Paolo, primary, Lyssiotis, Costas A., primary, Viale, Andrea, primary, and Draetta, Giulio F., primary

Published
2023
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10. Video 1 from Phage-Based Anti-HER2 Vaccination Can Circumvent Immune Tolerance against Breast Cancer

Author

Bartolacci, Caterina, primary, Andreani, Cristina, primary, Curcio, Claudia, primary, Occhipinti, Sergio, primary, Massaccesi, Luca, primary, Giovarelli, Mirella, primary, Galeazzi, Roberta, primary, Iezzi, Manuela, primary, Tilio, Martina, primary, Gambini, Valentina, primary, Wang, Junbiao, primary, Marchini, Cristina, primary, and Amici, Augusto, primary

Published
2023
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11. Supplementary S1 from Phage-Based Anti-HER2 Vaccination Can Circumvent Immune Tolerance against Breast Cancer

Author

Bartolacci, Caterina, primary, Andreani, Cristina, primary, Curcio, Claudia, primary, Occhipinti, Sergio, primary, Massaccesi, Luca, primary, Giovarelli, Mirella, primary, Galeazzi, Roberta, primary, Iezzi, Manuela, primary, Tilio, Martina, primary, Gambini, Valentina, primary, Wang, Junbiao, primary, Marchini, Cristina, primary, and Amici, Augusto, primary

Published
2023
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12. Supplementary Figures from Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma

Author

Puca, Francesca, primary, Yu, Fei, primary, Bartolacci, Caterina, primary, Pettazzoni, Piergiorgio, primary, Carugo, Alessandro, primary, Huang-Hobbs, Emmet, primary, Liu, Jintan, primary, Zanca, Ciro, primary, Carbone, Federica, primary, Del Poggetto, Edoardo, primary, Gumin, Joy, primary, Dasgupta, Pushan, primary, Seth, Sahil, primary, Srinivasan, Sanjana, primary, Lang, Frederick F., primary, Sulman, Erik P., primary, Lorenzi, Philip L., primary, Tan, Lin, primary, Shan, Mengrou, primary, Tolstyka, Zachary P., primary, Kachman, Maureen, primary, Zhang, Li, primary, Gao, Sisi, primary, Deem, Angela K., primary, Genovese, Giannicola, primary, Scaglioni, Pier Paolo, primary, Lyssiotis, Costas A., primary, Viale, Andrea, primary, and Draetta, Giulio F., primary

Published
2023
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13. Supplementary Tables from Phage-Based Anti-HER2 Vaccination Can Circumvent Immune Tolerance against Breast Cancer

Author

Bartolacci, Caterina, primary, Andreani, Cristina, primary, Curcio, Claudia, primary, Occhipinti, Sergio, primary, Massaccesi, Luca, primary, Giovarelli, Mirella, primary, Galeazzi, Roberta, primary, Iezzi, Manuela, primary, Tilio, Martina, primary, Gambini, Valentina, primary, Wang, Junbiao, primary, Marchini, Cristina, primary, and Amici, Augusto, primary

Published
2023
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14. Data from Phage-Based Anti-HER2 Vaccination Can Circumvent Immune Tolerance against Breast Cancer

Author

Bartolacci, Caterina, primary, Andreani, Cristina, primary, Curcio, Claudia, primary, Occhipinti, Sergio, primary, Massaccesi, Luca, primary, Giovarelli, Mirella, primary, Galeazzi, Roberta, primary, Iezzi, Manuela, primary, Tilio, Martina, primary, Gambini, Valentina, primary, Wang, Junbiao, primary, Marchini, Cristina, primary, and Amici, Augusto, primary

Published
2023
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16. HER2-Displaying M13 Bacteriophages induce Therapeutic Immunity against Breast Cancer

Author

Wang, Junbiao, primary, Lamolinara, Alessia, additional, Conti, Laura, additional, Giangrossi, Mara, additional, Cui, Lishan, additional, Morelli, Maria Beatrice, additional, Amantini, Consuelo, additional, Falconi, Maurizio, additional, Bartolacci, Caterina, additional, Andreani, Cristina, additional, Orlando, Fiorenza, additional, Provinciali, Mauro, additional, Del Pizzo, Francesco Domenico, additional, Russo, Francesca, additional, Belletti, Barbara, additional, Riccardo, Federica, additional, Bolli, Elisabetta, additional, Quaglino, Elena, additional, Cavallo, Federica, additional, Amici, Augusto, additional, Iezzi, Manuela, additional, and Marchini, Cristina, additional

Published
2022
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19. Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma

Author

Puca, Francesca, primary, Yu, Fei, additional, Bartolacci, Caterina, additional, Pettazzoni, Piergiorgio, additional, Carugo, Alessandro, additional, Huang-Hobbs, Emmet, additional, Liu, Jintan, additional, Zanca, Ciro, additional, Carbone, Federica, additional, Del Poggetto, Edoardo, additional, Gumin, Joy, additional, Dasgupta, Pushan, additional, Seth, Sahil, additional, Srinivasan, Sanjana, additional, Lang, Frederick F., additional, Sulman, Erik P., additional, Lorenzi, Philip L., additional, Tan, Lin, additional, Shan, Mengrou, additional, Tolstyka, Zachary P., additional, Kachman, Maureen, additional, Zhang, Li, additional, Gao, Sisi, additional, Deem, Angela K., additional, Genovese, Giannicola, additional, Scaglioni, Pier Paolo, additional, Lyssiotis, Costas A., additional, Viale, Andrea, additional, and Draetta, Giulio F., additional

Published
2021
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20. Targetingde novolipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer

Author

Bartolacci, Caterina, primary, Andreani, Cristina, additional, Vias Do Vale, Gonçalo, additional, Berto, Stefano, additional, Melegari, Margherita, additional, Crouch, Anna C., additional, Baluya, Dodge L., additional, Kemble, George, additional, Hodges, Kurt, additional, Starrett, Jacqueline, additional, Politi, Katerina, additional, Starnes, Sandra L., additional, Lorenzini, Daniele, additional, Raso, Maria Gabriela, additional, Soto, Luisa Solis, additional, Behrens, Carmen, additional, Kadara, Humam, additional, Gao, Boning, additional, Gerber, David, additional, Wistuba, Ignacio I., additional, Minna, John D., additional, McDonald, Jeffrey, additional, and Scaglioni, Pier Paolo, additional

Published
2021
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22. Phage-Based Anti-HER2 Vaccination Can Circumvent Immune Tolerance against Breast Cancer

Author

Bartolacci, Caterina, primary, Andreani, Cristina, additional, Curcio, Claudia, additional, Occhipinti, Sergio, additional, Massaccesi, Luca, additional, Giovarelli, Mirella, additional, Galeazzi, Roberta, additional, Iezzi, Manuela, additional, Tilio, Martina, additional, Gambini, Valentina, additional, Wang, Junbiao, additional, Marchini, Cristina, additional, and Amici, Augusto, additional

Published
2018
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29. Manipulation of lipoplex concentration at the cell surface boosts transfection efficiency in hard-to-transfect cells

Author

Francesco Cardarelli, Cristina Andreani, Valentina Gambini, Rocco Palermo, Sara Palchetti, Giulio Caracciolo, Carmine Di Rienzo, Luca Digiacomo, Daniela Pozzi, Giovanna Peruzzi, Caterina Bartolacci, Cristina Marchini, Isabella Screpanti, Heinz Amenitsch, Augusto Amici, Palchetti, Sara, Pozzi, Daniela, Marchini, Cristina, Amici, Augusto, Andreani, Cristina, Bartolacci, Caterina, Digiacomo, Luca, Gambini, Valentina, Cardarelli, Francesco, Di Rienzo, Carmine, Peruzzi, Giovanna, Amenitsch, Heinz, Palermo, Rocco, Screpanti, Isabella, and Caracciolo, Giulio

Subjects
0301 basic medicine, animal structures, viruses, Cell, Biomedical Engineering, Pharmaceutical Science, Medicine (miscellaneous), Bioengineering, 02 engineering and technology, Biology, Transfection, Jurkat cells, Cell transfection, Cell Line, 03 medical and health sciences, Dynamic light scattering, X-Ray Diffraction, Scattering, Small Angle, medicine, Animals, Humans, General Materials Science, Cationic liposome, Liposome, Hard-to-transfect cell, Animal, fungi, Transfection efficiency, DNA, Lipid, 021001 nanoscience & nanotechnology, Lipids, Cell biology, Lipoplexe, 030104 developmental biology, medicine.anatomical_structure, Cell culture, Lipofectamine, Cationic liposomes, Hard-to-transfect cells, Lipoplexes, Molecular Medicine, Materials Science (all), 3003, Liposomes, embryonic structures, 0210 nano-technology, Human
Abstract

To date, efficiency upon non-viral DNA delivery remains low and this implies the existence of unidentified transfection barriers. Here we explore the mechanisms of action of multicomponent (MC) cationic liposome/DNA complexes (lipoplexes) by a combination of reporter technologies, dynamic light scattering (DLS), synchrotron small angle X-ray scattering (SAXS), fluorescence activated cell sorting (FACS) analysis and laser scanning confocal microscopy (LSCM) in live cells. Lipofectamine - the gold standard among transfection reagents - was used as a reference. On the basis of our results, we suggest that an additional transfection barrier impairs transfection efficiency, that is: low lipoplex concentration at the cell surface. Based on the acquired knowledge we propose an optimized transfection protocol that allowed us to efficiently transfect DND41, JURKAT, MOLT3, P12-ICHIKAWA, ALL-SILL, TALL-1 human T-cell acute lymphoblastic leukemia (T-ALL) cell lines known to be difficult-to-transfect by using non-viral vectors and where LFN-based technologies fail to give satisfactory results.

Published
2017

30. Copper Drives Remodeling of Metabolic State and Progression of Clear Cell Renal Cell Carcinoma.

Author

Bischoff ME, Shamsaei B, Yang J, Secic D, Vemuri B, Reisz JA, D'Alessandro A, Bartolacci C, Adamczak R, Schmidt L, Wang J, Martines A, Venkat J, Tcheuyap VT, Biesiada J, Behrmann CA, Vest KE, Brugarolas J, Scaglioni PP, Plas DR, Patra KC, Gulati S, Landero Figueroa JA, Meller J, Cunningham JT, and Czyzyk-Krzeska MF

Subjects
Humans, Glucose metabolism, Carcinoma, Renal Cell metabolism, Carcinoma, Renal Cell pathology, Copper metabolism, Kidney Neoplasms metabolism, Kidney Neoplasms pathology, Disease Progression
Abstract

Significance: The work establishes a requirement for glucose-dependent coordination between energy production and redox homeostasis, which is fundamental for the survival of cancer cells that accumulate Cu and contributes to tumor growth., (©2024 The Authors; Published by the American Association for Cancer Research.)

Published
2025
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31. Copper drives remodeling of metabolic state and progression of clear cell renal cell carcinoma.

Author

Bischoff ME, Shamsaei B, Yang J, Secic D, Vemuri B, Reisz JA, D'Alessandro A, Bartolacci C, Adamczak R, Schmidt L, Wang J, Martines A, Biesiada J, Vest KE, Scaglioni PP, Plas DR, Patra KC, Gulati S, Figueroa JAL, Meller J, Cunningham JT, and Czyzyk-Krzeska MF

Abstract

Copper (Cu) is an essential trace element required for mitochondrial respiration. Late-stage clear cell renal cell carcinoma (ccRCC) accumulates Cu and allocates it to mitochondrial cytochrome c oxidase. We show that Cu drives coordinated metabolic remodeling of bioenergy, biosynthesis and redox homeostasis, promoting tumor growth and progression of ccRCC. Specifically, Cu induces TCA cycle-dependent oxidation of glucose and its utilization for glutathione biosynthesis to protect against H 2 O 2 generated during mitochondrial respiration, therefore coordinating bioenergy production with redox protection. scRNA-seq determined that ccRCC progression involves increased expression of subunits of respiratory complexes, genes in glutathione and Cu metabolism, and NRF2 targets, alongside a decrease in HIF activity, a hallmark of ccRCC. Spatial transcriptomics identified that proliferating cancer cells are embedded in clusters of cells with oxidative metabolism supporting effects of metabolic states on ccRCC progression. Our work establishes novel vulnerabilities with potential for therapeutic interventions in ccRCC. Accumulation of copper is associated with progression and relapse of ccRCC and drives tumor growth.Cu accumulation and allocation to cytochrome c oxidase (CuCOX) remodels metabolism coupling energy production and nucleotide biosynthesis with maintenance of redox homeostasis.Cu induces oxidative phosphorylation via alterations in the mitochondrial proteome and lipidome necessary for the formation of the respiratory supercomplexes. Cu stimulates glutathione biosynthesis and glutathione derived specifically from glucose is necessary for survival of Cu Hi cells. Biosynthesis of glucose-derived glutathione requires activity of glutamyl pyruvate transaminase 2, entry of glucose-derived pyruvate to mitochondria via alanine, and the glutamate exporter, SLC25A22. Glutathione derived from glucose maintains redox homeostasis in Cu-treated cells, reducing Cu-H 2 O 2 Fenton-like reaction mediated cell death. Progression of human ccRCC is associated with gene expression signature characterized by induction of ETC/OxPhos/GSH/Cu-related genes and decrease in HIF/glycolytic genes in subpopulations of cancer cells. Enhanced, concordant expression of genes related to ETC/OxPhos, GSH, and Cu characterizes metabolically active subpopulations of ccRCC cells in regions adjacent to proliferative subpopulations of ccRCC cells, implicating oxidative metabolism in supporting tumor growth.

Published
2024
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