1. pH-dependent cytotoxic effects of extracts of the marine sponge Polymastia janeirensis on cancer cell lines
- Author
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João Luís Carraro, José Cláudio Fonseca Moreira, Renata Biegelmeyer, Douglas F. Rambo, Mário L C da Frota Junior, Rafael Schröder, Roger R. Dresch, Beatriz Mothes B, and Amélia T. Henriques
- Subjects
Antioxidant ,medicine.medical_treatment ,Plant Science ,Orange (colour) ,01 natural sciences ,Biochemistry ,Analytical Chemistry ,03 medical and health sciences ,0302 clinical medicine ,Neuroblastoma ,medicine ,Cytotoxic T cell ,neoplasms ,biology ,Organic Chemistry ,biology.organism_classification ,medicine.disease ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Sponge ,Clotting time ,030220 oncology & carcinogenesis ,Immunology ,Cancer cell ,Polymastia janeirensis - Abstract
The purpose of this work was to study the cytotoxic effects of marine sponge Polymastia janeirensis, which has been observed in the field to release an orange substance that is toxic to fish. The result showed that aqueous extract (pH 7.0) was highly cytotoxic to glioma (U87) and neuroblastoma (SHSY5Y) cancer cell lines (IC50
- Published
- 2016