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2. Molecular and Other Ancillary Tests

Author

Nishino, Michiya, VanderLaan, Paul, Troncone, Giancarlo, Bellevicine, Claudio, Ohori, N. Paul, Kondo, Tetsuo, Buffet, Camille, Ali, Syed Z., editor, and VanderLaan, Paul A., editor

Published
2023
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3. How Molecular and Ancillary Tests Can Help in Challenging Cytopathology Cases: Insights from the International Molecular Cytopathology Meeting

Author

Vigliar, Elena, primary, Bellevicine, Claudio, additional, Acanfora, Gennaro, additional, Morales, Allan Argueta, additional, Carillo, Anna Maria, additional, Cozzolino, Domenico, additional, Nacchio, Mariantonia, additional, Luca, Caterina De, additional, Pisapia, Pasquale, additional, Lozano, Maria D., additional, Roy-Chowdhuri, Sinchita, additional, and Troncone, Giancarlo, additional

Published
2024
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4. A case of Kennedy terminal ulcer in a 17th-century Italian mummy

Author

Traversari, Mirko, primary, Ventura, Luca, additional, Iwaszczonek, Aleksander Sebastian, additional, Cilli, Elisabetta, additional, Longoni, Marco, additional, Pasquinelli, Gianandrea, additional, Troncone, Giancarlo, additional, Brunetti, Arturo, additional, Melandri, Davide, additional, and Bellevicine, Claudio, additional

Published
2024
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6. Editorial: Molecular characterization of thyroid lesions in the era of "next generation" techniques: volume II.

Author

Malapelle, Umberto, Bellevicine, Claudio, Friedlaender, Alex, Ciarrocchi, Alessia, and de Biase, Dario

Subjects
NUCLEOTIDE sequencing, AUTOIMMUNE thyroiditis, THYROID cancer, SOMATIC mutation, MEDULLARY thyroid carcinoma, ROOT-tubercles, MOLECULAR pathology
Abstract

This editorial published in the journal Frontiers in Endocrinology discusses the advancements in thyroid cancer research, specifically focusing on molecular characterization and prediction models for recurrence. The article emphasizes the importance of accurate molecular and genetic characterization to differentiate between less aggressive and more aggressive thyroid tumors. It also explores the use of biomarkers and prediction models to improve the diagnosis and management of thyroid nodules. The document provides a summary of three studies related to thyroid cancer research, which identify genes associated with recurrence, analyze the genetic landscape of thyroid cancer in Chinese patients, and investigate the shared molecular mechanisms between thyroid cancer and Hashimoto's thyroiditis. These studies contribute to our understanding of thyroid cancer and may lead to personalized treatment options. [Extracted from the article]

Published
2024
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7. Interobserver variability in cytopathology: How much do we agree?

Author

Acanfora, Gennaro, Carillo, Anna Maria, Dello Iacovo, Filippo, Salatiello, Maria, Pisapia, Pasquale, Bellevicine, Claudio, Troncone, Giancarlo, and Vigliar, Elena

Subjects
CELLULAR pathology, SALIVARY glands, DIFFERENTIAL diagnosis
Abstract

Interobserver variability remains a major challenge for cytopathologists despite the development of standardized reporting and classification systems. Indeed, whereas moderate‐to‐good interobserver agreement is generally achievable when the differential diagnosis between benign and malignant entities is straightforward, high levels of variability make the diagnostic interpretation of atypical and suspicious samples not consistent. This review explores the landscape of interobserver agreement in cytopathology across different anatomical sites. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Delphi expert consensus for whole slide imaging in thyroid cytopathology

Author

Marletta, Stefano, primary, Salatiello, Maria, additional, Pantanowitz, Liron, additional, Bellevicine, Claudio, additional, Bongiovanni, Massimo, additional, Bonoldi, Emanuela, additional, De Rezende, Gisele, additional, Fadda, Guido, additional, Incardona, Paolo, additional, Munari, Enrico, additional, Pagni, Fabio, additional, Rossi, Esther Diana, additional, Tallini, Giovanni, additional, Troncone, Giancarlo, additional, Ugolini, Clara, additional, Vigliar, Elena, additional, and Eccher, Albino, additional

Published
2023
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13. Delphi expert consensus for whole slide imaging in thyroid cytopathology

Author

Marletta, S, Salatiello, M, Pantanowitz, L, Bellevicine, C, Bongiovanni, M, Bonoldi, E, De Rezende, G, Fadda, G, Incardona, P, Munari, E, Pagni, F, Rossi, E, Tallini, G, Troncone, G, Ugolini, C, Vigliar, E, Eccher, A, Marletta, Stefano, Salatiello, Maria, Pantanowitz, Liron, Bellevicine, Claudio, Bongiovanni, Massimo, Bonoldi, Emanuela, De Rezende, Gisele, Fadda, Guido, Incardona, Paolo, Munari, Enrico, Pagni, Fabio, Rossi, Esther Diana, Tallini, Giovanni, Troncone, Giancarlo, Ugolini, Clara, Vigliar, Elena, Eccher, Albino, Marletta, S, Salatiello, M, Pantanowitz, L, Bellevicine, C, Bongiovanni, M, Bonoldi, E, De Rezende, G, Fadda, G, Incardona, P, Munari, E, Pagni, F, Rossi, E, Tallini, G, Troncone, G, Ugolini, C, Vigliar, E, Eccher, A, Marletta, Stefano, Salatiello, Maria, Pantanowitz, Liron, Bellevicine, Claudio, Bongiovanni, Massimo, Bonoldi, Emanuela, De Rezende, Gisele, Fadda, Guido, Incardona, Paolo, Munari, Enrico, Pagni, Fabio, Rossi, Esther Diana, Tallini, Giovanni, Troncone, Giancarlo, Ugolini, Clara, Vigliar, Elena, and Eccher, Albino

Abstract

Objective: Despite an increase in thyroid fine needle aspiration (FNA) and advances in whole slide imaging (WSI) adoption, digital pathology is still considered inadequate for primary diagnosis of these cases. Herein, we aim to validate the utility of WSI in thyroid FNAs employing the Delphi method strategy. Methods: A panel of experts from seven reference cytology centres was recruited. The study consisted of two consecutive rounds: (1) an open-ended, free-response questionnaire generating a list of survey items; and (2) a consensus analysis of 80 selected shared WSIs from 80 cases by six investigators answering six morphological questions utilising a 1 to 5 Likert scale. Results: High consensus was achieved for all parameters, with an overall average score of 4.27. The broad majority of items (84%) were ranked either 4 or 5 by each physician. Two badly scanned cases were responsible for more than half of the low-ranked (≤2) values (57%). Good to excellent (≥3) diagnostic confidence was reached in more than 95.2% of cases. For most cases (78%) WSI assessment was not limited by technical issues linked to the image acquisition process. Conclusion: This systematic Delphi study indicates broad consensus among participating physicians on the application of DP to thyroid cytopathology, supporting expert opinion that WSI is reliable and safe for primary diagnostic purposes.

Published
2023

14. Spatially Resolved Molecular Approaches for the Characterisation of Non-Invasive Follicular Tumours with Papillary-like Features (NIFTPs)

Author

Piga, I, L'Imperio, V, Principi, L, Bellevicine, C, Fusco, N, Maffini, F, Venetis, K, Ivanova, M, Seminati, D, Casati, G, Pagani, L, Galimberti, S, Capitoli, G, Garancini, M, Gatti, A, Magni, F, Pagni, F, Piga, Isabella, L'Imperio, Vincenzo, Principi, Lucrezia, Bellevicine, Claudio, Fusco, Nicola, Maffini, Fausto, Venetis, Konstantinos, Ivanova, Mariia, Seminati, Davide, Casati, Gabriele, Pagani, Lisa, Galimberti, Stefania, Capitoli, Giulia, Garancini, Mattia, Gatti, Andrea-Valer, Magni, Fulvio, Pagni, Fabio, Piga, I, L'Imperio, V, Principi, L, Bellevicine, C, Fusco, N, Maffini, F, Venetis, K, Ivanova, M, Seminati, D, Casati, G, Pagani, L, Galimberti, S, Capitoli, G, Garancini, M, Gatti, A, Magni, F, Pagni, F, Piga, Isabella, L'Imperio, Vincenzo, Principi, Lucrezia, Bellevicine, Claudio, Fusco, Nicola, Maffini, Fausto, Venetis, Konstantinos, Ivanova, Mariia, Seminati, Davide, Casati, Gabriele, Pagani, Lisa, Galimberti, Stefania, Capitoli, Giulia, Garancini, Mattia, Gatti, Andrea-Valer, Magni, Fulvio, and Pagni, Fabio

Abstract

Noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP) are low-risk thyroid lesions most often characterised by RAS-type mutations. The histological diagnosis may be challenging, and even immunohistochemistry and molecular approaches have not yet provided conclusive solutions. This study characterises a set of NIFTPs by Matrix-Assisted Laser Desorption/Ionisation (MALDI)-Mass Spectrometry Imaging (MSI) to highlight the proteomic signatures capable of overcoming histological challenges. Archived formalin-fixed paraffin-embedded samples from 10 NIFTPs (n = 6 RAS-mutated and n = 4 RAS-wild type) were trypsin-digested and analysed by MALDI-MSI, comparing their profiles to normal tissue and synchronous benign nodules. This allowed the definition of a four-peptide signature able to distinguish RAS-mutant from wild-type cases, the latter showing proteomic similarities to hyperplastic nodules. Moreover, among the differentially expressed signals, Peptidylprolyl Isomerase A (PPIA, 1505.8 m/z), which has already demonstrated a role in the development of cancer, was found overexpressed in NIFTP RAS-mutated nodules compared to wild-type lesions. These results underlined that high-throughput proteomic approaches may add a further level of biological comprehension for NIFTPs. In the future, thanks to the powerful single-cell detail achieved by new instruments, the complementary NGS-MALDI imaging sequence might be the correct methodological approach to confirm that the current NIFTP definition encompasses heterogeneous lesions that must be further characterised.

Published
2023

15. Reference standards for gene fusion molecular assays on cytological samples: an international validation study

Author

Malapelle, U, Pepe, F, Pisapia, P, Altimari, A, Bellevicine, C, Brunnström, H, Bruno, R, Büttner, R, Cirnes, L, De Andrea, C, de Biase, D, Dumur, C, Ericson Lindquist, K, Fontanini, G, Gautiero, E, Gentien, D, Hofman, P, Hofman, V, Iaccarino, A, Lozano, M, Mayo-de-Las-Casas, C, Merkelbach-Bruse, S, Pagni, F, Roman, R, Schmitt, F, Siemanowski, J, Roy-Chowdhuri, S, Tallini, G, Tresserra, F, Vander Borght, S, Vielh, P, Vigliar, E, Vita, G, Weynand, B, Rosell, R, Molina Vila, M, Troncone, G, Malapelle, Umberto, Pepe, Francesco, Pisapia, Pasquale, Altimari, Annalisa, Bellevicine, Claudio, Brunnström, Hans, Bruno, Rossella, Büttner, Reinhard, Cirnes, Luis, De Andrea, Carlos E, de Biase, Dario, Dumur, Catherine I, Ericson Lindquist, Kajsa, Fontanini, Gabriella, Gautiero, Eugenio, Gentien, David, Hofman, Paul, Hofman, Veronique, Iaccarino, Antonino, Lozano, Maria Dolores, Mayo-de-Las-Casas, Clara, Merkelbach-Bruse, Sabine, Pagni, Fabio, Roman, Ruth, Schmitt, Fernando C, Siemanowski, Janna, Roy-Chowdhuri, Sinchita, Tallini, Giovanni, Tresserra, Francesc, Vander Borght, Sara, Vielh, Philippe, Vigliar, Elena, Vita, Giulia Anna Carmen, Weynand, Birgit, Rosell, Rafael, Molina Vila, Miguel Angel, Troncone, Giancarlo, Malapelle, U, Pepe, F, Pisapia, P, Altimari, A, Bellevicine, C, Brunnström, H, Bruno, R, Büttner, R, Cirnes, L, De Andrea, C, de Biase, D, Dumur, C, Ericson Lindquist, K, Fontanini, G, Gautiero, E, Gentien, D, Hofman, P, Hofman, V, Iaccarino, A, Lozano, M, Mayo-de-Las-Casas, C, Merkelbach-Bruse, S, Pagni, F, Roman, R, Schmitt, F, Siemanowski, J, Roy-Chowdhuri, S, Tallini, G, Tresserra, F, Vander Borght, S, Vielh, P, Vigliar, E, Vita, G, Weynand, B, Rosell, R, Molina Vila, M, Troncone, G, Malapelle, Umberto, Pepe, Francesco, Pisapia, Pasquale, Altimari, Annalisa, Bellevicine, Claudio, Brunnström, Hans, Bruno, Rossella, Büttner, Reinhard, Cirnes, Luis, De Andrea, Carlos E, de Biase, Dario, Dumur, Catherine I, Ericson Lindquist, Kajsa, Fontanini, Gabriella, Gautiero, Eugenio, Gentien, David, Hofman, Paul, Hofman, Veronique, Iaccarino, Antonino, Lozano, Maria Dolores, Mayo-de-Las-Casas, Clara, Merkelbach-Bruse, Sabine, Pagni, Fabio, Roman, Ruth, Schmitt, Fernando C, Siemanowski, Janna, Roy-Chowdhuri, Sinchita, Tallini, Giovanni, Tresserra, Francesc, Vander Borght, Sara, Vielh, Philippe, Vigliar, Elena, Vita, Giulia Anna Carmen, Weynand, Birgit, Rosell, Rafael, Molina Vila, Miguel Angel, and Troncone, Giancarlo

Abstract

AIMS: Gene fusions assays are key for personalised treatments of advanced human cancers. Their implementation on cytological material requires a preliminary validation that may make use of cell line slides mimicking cytological samples. In this international multi-institutional study, gene fusion reference standards were developed and validated. METHODS: Cell lines harbouring EML4(13)-ALK(20) and SLC34A2(4)-ROS1(32) gene fusions were adopted to prepare reference standards. Eight laboratories (five adopting amplicon-based and three hybridisation-based platforms) received, at different dilution points two sets of slides (slide A 50.0%, slide B 25.0%, slide C 12.5% and slide D wild type) stained by Papanicolaou (Pap) and May Grunwald Giemsa (MGG). Analysis was carried out on a total of 64 slides. RESULTS: Four (50.0%) out of eight laboratories reported results on all slides and dilution points. While 12 (37.5%) out of 32 MGG slides were inadequate, 27 (84.4%) out of 32 Pap slides produced libraries adequate for variant calling. The laboratories using hybridisation-based platforms showed the highest rate of inadequate results (13/24 slides, 54.2%). Conversely, only 10.0% (4/40 slides) of inadequate results were reported by laboratories adopting amplicon-based platforms. CONCLUSIONS: Reference standards in cytological format yield better results when Pap staining and processed by amplicon-based assays. Further investigation is required to optimise these standards for MGG stained cells and for hybridisation-based approaches.

Published
2023

16. Evaluating local thyroid cytopathology practices by molecular quality metrics: A multi‐institutional study on 4651 FNAs with a focus on the role of the interventional cytopathologist.

Author

Nacchio, Mariantonia, Palladino, Raffaele, Vigliar, Elena, Pisapia, Pasquale, Salatiello, Maria, Malapelle, Umberto, Porcelli, Tommaso, Luongo, Cristina, Fonderico, Francesco, Masone, Stefania, Salvatore, Domenico, Troncone, Giancarlo, and Bellevicine, Claudio

Abstract

Background: The diagnostic accuracy of thyroid fine‐needle aspiration (FNA) can be highly influenced by the technical skills of the operator performing the procedure and by interobserver variability in microscopic interpretation. This is particularly true for the indeterminate categories. Recently, molecular testing has been proposed as an ancillary tool for monitoring the performance of different thyroid cytopathology practices. The objective of this multicenter study was to evaluate the quality of different local cytopathology practices by assessing the impact of interventional cytopathologists on FNA adequacy for molecular testing and the variations in mutation rates across different health care centers operating in the Campania region. Methods: The study included 4651 thyroid FNA samples diagnosed in different Southern Italian clinical laboratories belonging to the TIRNET (the Tiroide Network). FNA samples were collected by different proceduralists and were classified by local cytopathologists according to The Bethesda System for Reporting Thyroid Cytopathology. FNAs classified as atypia of undetermined significance, follicular neoplasm, suspicious for malignancy, and malignant were centralized for a real‐time polymerase chain reaction‐based, seven‐gene test at the authors' institution. Results: Centers that employed interventional cytopathologists obtained fewer unsatisfactory FNA samples for molecular testing (11.3%) than centers that employed noncytopathologists (16.7%; p <.05). Furthermore, a significant variation in the mutation rate was observed in FNAs diagnosed by different local cytopathologists; indeterminate categories had the highest percentage of mutation rate variability among centers. Conclusions: Interventional cytopathologists obtained higher yields of diagnostic material for molecular testing. Finally, the current results suggest that the variability in mutation rates among different centers may highlight the low reproducibility of microscopic criteria among cytopathologists, particularly for indeterminate cases. Molecular testing has been proposed as an ancillary tool to monitor the performance of different thyroid cytopathology practices. In this multicenter study, the quality of different local cytopathology practices was evaluated by assessing the impact of interventional cytopathologists on fine‐needle aspiration adequacy for molecular testing and the variations in mutation rates across different health care centers operating in the Campania region of Italy. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Supplemental Table 2 from SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer

Author

Della Corte, Carminia Maria, primary, Bellevicine, Claudio, primary, Vicidomini, Giovanni, primary, Vitagliano, Donata, primary, Malapelle, Umberto, primary, Accardo, Marina, primary, Fabozzi, Alessio, primary, Fiorelli, Alfonso, primary, Fasano, Morena, primary, Papaccio, Federica, primary, Martinelli, Erika, primary, Troiani, Teresa, primary, Troncone, Giancarlo, primary, Santini, Mario, primary, Bianco, Roberto, primary, Ciardiello, Fortunato, primary, and Morgillo, Floriana, primary

Published
2023
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18. Supplemental Figure 1 from SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer

Author

Della Corte, Carminia Maria, primary, Bellevicine, Claudio, primary, Vicidomini, Giovanni, primary, Vitagliano, Donata, primary, Malapelle, Umberto, primary, Accardo, Marina, primary, Fabozzi, Alessio, primary, Fiorelli, Alfonso, primary, Fasano, Morena, primary, Papaccio, Federica, primary, Martinelli, Erika, primary, Troiani, Teresa, primary, Troncone, Giancarlo, primary, Santini, Mario, primary, Bianco, Roberto, primary, Ciardiello, Fortunato, primary, and Morgillo, Floriana, primary

Published
2023
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19. Data from SMO Gene Amplification and Activation of the Hedgehog Pathway as Novel Mechanisms of Resistance to Anti-Epidermal Growth Factor Receptor Drugs in Human Lung Cancer

Author

Della Corte, Carminia Maria, primary, Bellevicine, Claudio, primary, Vicidomini, Giovanni, primary, Vitagliano, Donata, primary, Malapelle, Umberto, primary, Accardo, Marina, primary, Fabozzi, Alessio, primary, Fiorelli, Alfonso, primary, Fasano, Morena, primary, Papaccio, Federica, primary, Martinelli, Erika, primary, Troiani, Teresa, primary, Troncone, Giancarlo, primary, Santini, Mario, primary, Bianco, Roberto, primary, Ciardiello, Fortunato, primary, and Morgillo, Floriana, primary

Published
2023
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21. Spatially Resolved Molecular Approaches for the Characterisation of Non-Invasive Follicular Tumours with Papillary-like Features (NIFTPs)

Author

Piga, Isabella, primary, L’Imperio, Vincenzo, additional, Principi, Lucrezia, additional, Bellevicine, Claudio, additional, Fusco, Nicola, additional, Maffini, Fausto, additional, Venetis, Konstantinos, additional, Ivanova, Mariia, additional, Seminati, Davide, additional, Casati, Gabriele, additional, Pagani, Lisa, additional, Galimberti, Stefania, additional, Capitoli, Giulia, additional, Garancini, Mattia, additional, Gatti, Andrea-Valer, additional, Magni, Fulvio, additional, and Pagni, Fabio, additional

Published
2023
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22. Type 2 deiodinase Thr92Ala polymorphism and aging are associated with a decreased pituitary sensitivity to thyroid hormone

Author

Luongo, Cristina, primary, De Stefano, Maria Angela, additional, Ambrosio, Raffaele, additional, volpe, fabio, additional, Porcelli, Tommaso, additional, Golia, Valeria, additional, Bellevicine, Claudio, additional, Troncone, Giancarlo, additional, Masone, Stefania, additional, Damiano, Vincenzo, additional, Matano, Elide, additional, Klain, Michele, additional, Schlumberger, Martin, additional, and Salvatore, Domenico, additional

Published
2023
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23. Interventional cytopathologist can successfully combine ultrasonographical and microscopic skills to narrow the differential diagnosis in fine needle aspiration of neck paraganglioma

Author

Carillo, Anna Maria, primary, Franca, Raduan Ahmed, additional, Modica, Roberta, additional, De Caro, Marialaura Del Basso, additional, Pisapia, Pasquale, additional, Vigliar, Elena, additional, Troncone, Giancarlo, additional, and Bellevicine, Claudio, additional

Published
2022
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26. Relevance of the College of American Pathologists guideline for validating whole slide imaging for diagnostic purposes to cytopathology

Author

Antonini, Pietro, primary, Santonicco, Nicola, additional, Pantanowitz, Liron, additional, Girolami, Ilaria, additional, Rizzo, Paola Chiara, additional, Brunelli, Matteo, additional, Bellevicine, Claudio, additional, Vigliar, Elena, additional, Negri, Giovanni, additional, Troncone, Giancarlo, additional, Fadda, Guido, additional, Parwani, Anil, additional, Marletta, Stefano, additional, and Eccher, Albino, additional

Published
2022
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28. RNA-based next-generation sequencing in non-small-cell lung cancer in a routine setting: an experience from an Italian referral center

Author

Luca, Caterina De, primary, Pepe, Francesco, additional, Pisapia, Pasquale, additional, Iaccarino, Antonino, additional, Righi, Luisella, additional, Listì, Angela, additional, Russo, Gianluca, additional, Campione, Severo, additional, Pagni, Fabio, additional, Nacchio, Mariantonia, additional, Conticelli, Floriana, additional, Russo, Maria, additional, Fabozzi, Teresa, additional, Vigliar, Elena, additional, Bellevicine, Claudio, additional, Rocco, Danilo, additional, Laudati, Stefano, additional, Iannaci, Giuseppe, additional, Daniele, Bruno, additional, Gridelli, Cesare, additional, Cortinovis, Diego Luigi, additional, Novello, Silvia, additional, Molina-Vila, Miguel Angel, additional, Rosell, Rafael, additional, Troncone, Giancarlo, additional, and Malapelle, Umberto, additional

Published
2022
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29. Thyroid Cancer and Fibroblasts

Author

Avagliano, Angelica, primary, Fiume, Giuseppe, additional, Bellevicine, Claudio, additional, Troncone, Giancarlo, additional, Venuta, Alessandro, additional, Acampora, Vittoria, additional, De Lella, Sabrina, additional, Ruocco, Maria Rosaria, additional, Masone, Stefania, additional, Velotti, Nunzio, additional, Carotenuto, Pietro, additional, Mallardo, Massimo, additional, Caiazza, Carmen, additional, Montagnani, Stefania, additional, and Arcucci, Alessandro, additional

Published
2022
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30. Evaluation of the Molecular Landscape in PD-L1 Positive Metastatic NSCLC: Data from Campania, Italy

Author

Pisapia, Pasquale, primary, Iaccarino, Antonino, additional, De Luca, Caterina, additional, Acanfora, Gennaro, additional, Bellevicine, Claudio, additional, Bianco, Roberto, additional, Daniele, Bruno, additional, Ciampi, Luisa, additional, De Felice, Marco, additional, Fabozzi, Teresa, additional, Formisano, Luigi, additional, Giordano, Pasqualina, additional, Gridelli, Cesare, additional, Ianniello, Giovanni Pietro, additional, Libroia, Annamaria, additional, Maione, Paolo, additional, Nacchio, Mariantonia, additional, Pagni, Fabio, additional, Palmieri, Giovanna, additional, Pepe, Francesco, additional, Russo, Gianluca, additional, Salatiello, Maria, additional, Santaniello, Antonio, additional, Scamarcio, Rachele, additional, Seminati, Davide, additional, Troia, Michele, additional, Troncone, Giancarlo, additional, Vigliar, Elena, additional, and Malapelle, Umberto, additional

Published
2022
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31. Liquid Biopsy in Prostate Cancer Management—Current Challenges and Future Perspectives

Author

Crocetto, Felice, primary, Russo, Gianluca, additional, Di Zazzo, Erika, additional, Pisapia, Pasquale, additional, Mirto, Benito Fabio, additional, Palmieri, Alessandro, additional, Pepe, Francesco, additional, Bellevicine, Claudio, additional, Russo, Alessandro, additional, La Civita, Evelina, additional, Terracciano, Daniela, additional, Malapelle, Umberto, additional, Troncone, Giancarlo, additional, and Barone, Biagio, additional

Published
2022
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32. COVID-19 pandemic impact on cytopathology practice in the post-lockdown period: An international, multicenter study

Author

Vigliar, Elena, Pisapia, Pasquale, Dello Iacovo, Filippo, Alcaraz-Mateos, Eduardo, Ali, Greta, Ali, Syed Z., Baloch, Zubair W., Bellevicine, Claudio, Bongiovanni, Massimo, Botsun, Pavlina, Bruzzese, Dario, Bubendorf, Lukas, Buttner, Reinhard, Canberk, Sule, Capitanio, Arrigo, Casadio, Chiara, Cazacu, Eugeniu, Cochand-Priollet, Beatrix, D'Amuri, Alessandro, Davis, Katelynn, Eloy, Catarina, Engels, Marianne, Fadda, Guido, Fontanini, Gabriella, Fulciniti, Franco, Hofman, Paul, Iaccarino, Antonino, Ieni, Antonio, Jiang, Xiaoyin Sara, Kakudo, Kennichi, Kern, Izidor, Kholova, Ivana, McDermott, Kathryn M. Linton, Liu, Chinhua, Lobo, Anandi, Lozano, Maria D., Malapelle, Umberto, Maleki, Zahra, Michelow, Pamela, Mikula, Michael W., Musayev, Jamal, Ozgun, Gonca, Oznur, Meltem, Marques, Francisca Maria Peiro, Poller, David, Pyzlak, Michal, Robinson, Betsy, Rossi, Esther Diana, Roy-Chowdhuri, Sinchita, Saieg, Mauro, Prince, Spasenija Savic, Schmitt, Fernando C., Ivanez, Francisco Javier Segui, Stoos-Veic, Tajana, Sulaieva, Oksana, Sweeney, Brenda J., Tuccari, Giovanni, Van Velthuysen, Marie-Louise, VanderLaan, Paul A., Vielh, Philippe, Viola, Patrizia, Voorham, Quirinus J. M., Weynand, Birgit, Zeppa, Pio, Faquin, William C., Pitman, Martha Bishop, Troncone, Giancarlo, Vigliar, Elena, Pisapia, Pasquale, Dello Iacovo, Filippo, Alcaraz-Mateos, Eduardo, Ali, Greta, Ali, Syed Z., Baloch, Zubair W., Bellevicine, Claudio, Bongiovanni, Massimo, Botsun, Pavlina, Bruzzese, Dario, Bubendorf, Lukas, Buttner, Reinhard, Canberk, Sule, Capitanio, Arrigo, Casadio, Chiara, Cazacu, Eugeniu, Cochand-Priollet, Beatrix, D'Amuri, Alessandro, Davis, Katelynn, Eloy, Catarina, Engels, Marianne, Fadda, Guido, Fontanini, Gabriella, Fulciniti, Franco, Hofman, Paul, Iaccarino, Antonino, Ieni, Antonio, Jiang, Xiaoyin Sara, Kakudo, Kennichi, Kern, Izidor, Kholova, Ivana, McDermott, Kathryn M. Linton, Liu, Chinhua, Lobo, Anandi, Lozano, Maria D., Malapelle, Umberto, Maleki, Zahra, Michelow, Pamela, Mikula, Michael W., Musayev, Jamal, Ozgun, Gonca, Oznur, Meltem, Marques, Francisca Maria Peiro, Poller, David, Pyzlak, Michal, Robinson, Betsy, Rossi, Esther Diana, Roy-Chowdhuri, Sinchita, Saieg, Mauro, Prince, Spasenija Savic, Schmitt, Fernando C., Ivanez, Francisco Javier Segui, Stoos-Veic, Tajana, Sulaieva, Oksana, Sweeney, Brenda J., Tuccari, Giovanni, Van Velthuysen, Marie-Louise, VanderLaan, Paul A., Vielh, Philippe, Viola, Patrizia, Voorham, Quirinus J. M., Weynand, Birgit, Zeppa, Pio, Faquin, William C., Pitman, Martha Bishop, and Troncone, Giancarlo

Abstract

Background In a previous worldwide survey, the authors showed a drastic reduction in the number of cytological specimens processed during the coronavirus disease 2019 lockdown period along with an increase in malignancy rates. To assess the continued impact of the pandemic on cytological practices around the world, they undertook a second follow-up worldwide survey collecting data from the post-lockdown period (2020). Methods Participants were asked to provide data regarding their cytopathology activity during the first 12 weeks of their respective national post-lockdown period (2020), which ranged from April 4 to October 31. Differences between the post-lockdown period and the corresponding 2019 period were evaluated, and the authors specifically focused on rates of malignant diagnoses. Results A total of 29 respondents from 17 countries worldwide joined the survey. Overall, a lower number of cytological specimens (n = 236,352) were processed in comparison with the same period in 2019 (n = 321,466) for a relative reduction of 26.5%. The overall malignancy rate showed a statistically significant increase (12,442 [5.26%] vs 12,882 [4.01%]; P < .001) during the same time period. Similar results were obtained if both malignancy and suspicious for malignancy rates were considered together (15,759 [6.58%] vs 16,011 [4.98%]; P < .001). Conclusions The data showed a persistent reduction in the cytological specimen volume during the post-lockdown period (2020). However, the relative increase in the cytological workload in the late part of the post-lockdown is a promising finding of a slow return to normality.

Published
2022

33. Evaluation of the Molecular Landscape in PD-L1 Positive Metastatic NSCLC: Data from Campania, Italy

Author

Pisapia, P, Iaccarino, A, De Luca, C, Acanfora, G, Bellevicine, C, Bianco, R, Daniele, B, Ciampi, L, De Felice, M, Fabozzi, T, Formisano, L, Giordano, P, Gridelli, C, Ianniello, G, Libroia, A, Maione, P, Nacchio, M, Pagni, F, Palmieri, G, Pepe, F, Russo, G, Salatiello, M, Santaniello, A, Scamarcio, R, Seminati, D, Troia, M, Troncone, G, Vigliar, E, Malapelle, U, Pisapia, Pasquale, Iaccarino, Antonino, De Luca, Caterina, Acanfora, Gennaro, Bellevicine, Claudio, Bianco, Roberto, Daniele, Bruno, Ciampi, Luisa, De Felice, Marco, Fabozzi, Teresa, Formisano, Luigi, Giordano, Pasqualina, Gridelli, Cesare, Ianniello, Giovanni Pietro, Libroia, Annamaria, Maione, Paolo, Nacchio, Mariantonia, Pagni, Fabio, Palmieri, Giovanna, Pepe, Francesco, Russo, Gianluca, Salatiello, Maria, Santaniello, Antonio, Scamarcio, Rachele, Seminati, Davide, Troia, Michele, Troncone, Giancarlo, Vigliar, Elena, Malapelle, Umberto, Pisapia, P, Iaccarino, A, De Luca, C, Acanfora, G, Bellevicine, C, Bianco, R, Daniele, B, Ciampi, L, De Felice, M, Fabozzi, T, Formisano, L, Giordano, P, Gridelli, C, Ianniello, G, Libroia, A, Maione, P, Nacchio, M, Pagni, F, Palmieri, G, Pepe, F, Russo, G, Salatiello, M, Santaniello, A, Scamarcio, R, Seminati, D, Troia, M, Troncone, G, Vigliar, E, Malapelle, U, Pisapia, Pasquale, Iaccarino, Antonino, De Luca, Caterina, Acanfora, Gennaro, Bellevicine, Claudio, Bianco, Roberto, Daniele, Bruno, Ciampi, Luisa, De Felice, Marco, Fabozzi, Teresa, Formisano, Luigi, Giordano, Pasqualina, Gridelli, Cesare, Ianniello, Giovanni Pietro, Libroia, Annamaria, Maione, Paolo, Nacchio, Mariantonia, Pagni, Fabio, Palmieri, Giovanna, Pepe, Francesco, Russo, Gianluca, Salatiello, Maria, Santaniello, Antonio, Scamarcio, Rachele, Seminati, Davide, Troia, Michele, Troncone, Giancarlo, Vigliar, Elena, and Malapelle, Umberto

Abstract

Background: Immune-checkpoint inhibitors (ICIs) have increased and improved the treatment options for patients with non-oncogene-addicted advanced stage non-small cell lung cancer (NSCLC). However, the role of ICIs in oncogene-addicted advanced stage NSCLC patients is still debated. In this study, in an attempt to fill in the informational gap on the effect of ICIs on other driver mutations, we set out to provide a molecular landscape of clinically relevant oncogenic drivers in programmed death-ligand 1 (PD-L1) positive NSCLC patients. Methods: We retrospectively reviewed data on 167 advanced stage NSCLC PD-L1 positive patients (≥1%) who were referred to our clinic for molecular evaluation of five driver oncogenes, namely, EGFR, KRAS, BRAF, ALK and ROS1. Results: Interestingly, n = 93 (55.7%) patients showed at least one genomic alteration within the tested genes. Furthermore, analyzing a subset of patients with PD-L1 tumor proportion score (TPS) ≥ 50% and concomitant gene alterations (n = 8), we found that n = 3 (37.5%) of these patients feature clinical benefit with ICIs administration, despite the presence of a concomitant KRAS gene alteration. Conclusions: In this study, we provide a molecular landscape of clinically relevant biomarkers in NSCLC PD-L1 positive patients, along with data evidencing the clinical benefit of ICIs in patient NSCLC PD-L1 positive alterations.

Published
2022

39. Microsatellite instability evaluation of patients with solid tumour: routine practice insight from a large series of Italian referral centre

Author

Russo, Gianluca, primary, Pepe, Francesco, additional, Pisapia, Pasquale, additional, Palumbo, Lucia, additional, Nacchio, Mariantonia, additional, Vigliar, Elena, additional, Pallante, Pierlorenzo, additional, Parente, Paola, additional, Fassan, Matteo, additional, Graziano, Paolo, additional, Bellevicine, Claudio, additional, Troncone, Giancarlo, additional, Malapelle, Umberto, additional, and Iaccarino, Antonino, additional

Published
2022
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41. Paleopathological Approach to the Study of a Christian Relic: The Case of the Blessed Maria Lorenza Longo

Author

Traversari, Mirko, Ventura, Luca, Cilli, Elisabetta, Luiselli, Donata, Troncone, Giancarlo, Brunetti, Arturo, Cocozza, Sirio, Petrella, Enrico, Feeney, Robin N.M., and Bellevicine, Claudio

Subjects
paleoanthropology, paleoradiology, paleopathology, relics, neurosyphilis
Abstract

The Blessed Maria Lorenza Longo, founder of the hospital of Santa Maria del Popolo degli Incurabili and the Order of the Capuchin Poor Clares in Naples, Italy, died on 21 October 1539 and was recently beatified on 9 October 2021. The relic, a fully skeletonized cranium, underwent visual and radiological inspection. The biological profile supports the at¬tribution of female sex of the relic, whereas the age at death is estimated to be younger than that reported by historians. A paleopathological survey was conducted to evaluate the historical reports of poisoning or rheumatoid arthritis affecting Maria Longo. Given the limited skeletal data, it was not possible to confirm the presence of these claims. No obvious in¬dicators of dietary deficiencies were observed, and the tertiary syphilis hypothesized by textual sources was excluded. Postmortem alterations of the relic were clearly visible on the superior aspect of the cranium and testified to the worship of the relic.

Published
2022

42. Predictive molecular pathology in metastatic thyroid cancer: the role of RET fusions

Author

Nacchio, Mariantonia, primary, Pisapia, Pasquale, additional, Pepe, Francesco, additional, Russo, Gianluca, additional, Vigliar, Elena, additional, Porcelli, Tommaso, additional, Luongo, Cristina, additional, Iaccarino, Antonino, additional, Pagni, Fabio, additional, Salvatore, Domenico, additional, Troncone, Giancarlo, additional, Malapelle, Umberto, additional, and Bellevicine, Claudio, additional

Published
2022
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43. Application of the Milan System for Reporting Salivary Gland Cytopathology in pediatric patients: An international, multi‐institutional study

Author

Maleki, Zahra, primary, Saoud, Carla, additional, Viswanathan, Kartik, additional, Kilic, Irem, additional, Tommola, Erkka, additional, Griffin, Daniel T., additional, Heider, Amer, additional, Petrone, Gianluigi, additional, Jo, Vickie Y., additional, Centeno, Barbara A., additional, Saieg, Mauro, additional, Mikou, Panagiota, additional, Fadda, Guido, additional, Ali, Syed Z., additional, Kholová, Ivana, additional, Wojcik, Eva M., additional, Barkan, Güliz A., additional, Eisele, David W., additional, Bellevicine, Claudio, additional, Vigliar, Elena, additional, Wiles, Austin B., additional, Al‐Ibraheemi, Alyaa, additional, Allison, Derek B., additional, Dixon, Glen R., additional, Chandra, Ashish, additional, Walsh, Jonathan M., additional, Baloch, Zubair W., additional, Faquin, William C., additional, Krane, Jeffrey F., additional, Rossi, Esther Diana, additional, Pantanowitz, Liron, additional, Troncone, Giancarlo, additional, Callegari, Fabiano M., additional, and Klijanienko, Jerzy, additional

Published
2022
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45. COVID‐19 pandemic impact on cytopathology practice in the post‐lockdown period: An international, multicenter study

Author

Vigliar, Elena, primary, Pisapia, Pasquale, additional, Dello Iacovo, Filippo, additional, Alcaraz‐Mateos, Eduardo, additional, Alì, Greta, additional, Ali, Syed Z., additional, Baloch, Zubair W., additional, Bellevicine, Claudio, additional, Bongiovanni, Massimo, additional, Botsun, Pavlina, additional, Bruzzese, Dario, additional, Bubendorf, Lukas, additional, Büttner, Reinhard, additional, Canberk, Sule, additional, Capitanio, Arrigo, additional, Casadio, Chiara, additional, Cazacu, Eugeniu, additional, Cochand‐Priollet, Beatrix, additional, D’Amuri, Alessandro, additional, Davis, Katelynn, additional, Eloy, Catarina, additional, Engels, Marianne, additional, Fadda, Guido, additional, Fontanini, Gabriella, additional, Fulciniti, Franco, additional, Hofman, Paul, additional, Iaccarino, Antonino, additional, Ieni, Antonio, additional, Jiang, Xiaoyin Sara, additional, Kakudo, Kennichi, additional, Kern, Izidor, additional, Kholova, Ivana, additional, Linton McDermott, Kathryn M., additional, Liu, Chinhua, additional, Lobo, Anandi, additional, Lozano, Maria D., additional, Malapelle, Umberto, additional, Maleki, Zahra, additional, Michelow, Pamela, additional, Mikula, Michael W., additional, Musayev, Jamal, additional, Özgün, Gonca, additional, Oznur, Meltem, additional, Peiró Marqués, Francisca Maria, additional, Poller, David, additional, Pyzlak, Michal, additional, Robinson, Betsy, additional, Rossi, Esther Diana, additional, Roy‐Chowdhuri, Sinchita, additional, Saieg, Mauro, additional, Savic Prince, Spasenija, additional, Schmitt, Fernando C., additional, Seguí Iváñez, Francisco Javier, additional, Štoos‐Veić, Tajana, additional, Sulaieva, Oksana, additional, Sweeney, Brenda J., additional, Tuccari, Giovanni, additional, van Velthuysen, Marie‐Louise, additional, VanderLaan, Paul A., additional, Vielh, Philippe, additional, Viola, Patrizia, additional, Voorham, Quirinus J. M., additional, Weynand, Birgit, additional, Zeppa, Pio, additional, Faquin, William C., additional, Pitman, Martha Bishop, additional, and Troncone, Giancarlo, additional

Published
2022
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46. UbcH10 Expression Can Predict Prognosis and Sensitivity to the Antineoplastic Treatment for Colorectal Cancer Patients

Author

Cacciola, Nunzio Antonio, Calabrese, Chiara, Malapelle, Umberto, Pellino, Gianluca, De Stefano, Alfonso, Sepe, Romina, Sgariglia, Roberta, Quintavalle, Cristina, Federico, Antonella, Bianco, Antonio, Uchimura Bastos, André, Milone, Marco, Bellevicine, Claudio, Milone, Francesco, Carlomagno, Chiara, Selvaggi, Francesco, Troncone, Giancarlo, Fusco, Alfredo, and Pallante, Pierlorenzo

Published
2016
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48. Microsatellite instability evaluation of patients with solid tumour: routine practice insight from a large series of Italian referral centre.

Author

Russo, Gianluca, Pepe, Francesco, Pisapia, Pasquale, Palumbo, Lucia, Nacchio, Mariantonia, Vigliar, Elena, Pallante, Pierlorenzo, Parente, Paola, Fassan, Matteo, Graziano, Paolo, Bellevicine, Claudio, Troncone, Giancarlo, Malapelle, Umberto, and Iaccarino, Antonino

Subjects
DNA mismatch repair, MICROSATELLITE repeats, HEREDITARY nonpolyposis colorectal cancer
Published
2023
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49. Interventional cytopathologist can successfully combine ultrasonographical and microscopic skills to narrow the differential diagnosis in fine needle aspiration of neck paraganglioma.

Author

Carillo, Anna Maria, Franca, Raduan Ahmed, Modica, Roberta, De Caro, Marialaura Del Basso, Pisapia, Pasquale, Vigliar, Elena, Troncone, Giancarlo, and Bellevicine, Claudio

Subjects
NEEDLE biopsy, PARAGANGLIOMA, DIFFERENTIAL diagnosis, NECK
Abstract

The interventional cytopathologist can successfully refine the differential diagnosis of a neck mass by combining ultrasonographical and morphological skills as shown in this case of head and neck paraganglioma, which was suspected thanks to ultrasound features and rapid‐on site evaluation and further confirmed by immunocytochemistry on cell block and by the subsequent histologic evaluation. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Relevance of the College of American Pathologists guideline for validating whole slide imaging for diagnostic purposes to cytopathology.

Author

Antonini, Pietro, Santonicco, Nicola, Pantanowitz, Liron, Girolami, Ilaria, Rizzo, Paola Chiara, Brunelli, Matteo, Bellevicine, Claudio, Vigliar, Elena, Negri, Giovanni, Troncone, Giancarlo, Fadda, Guido, Parwani, Anil, Marletta, Stefano, and Eccher, Albino

Subjects
CYTODIAGNOSIS, PATHOLOGISTS, DIAGNOSTIC imaging, CELLULAR pathology, PATHOLOGY
Abstract

Whole slide imaging (WSI) allows pathologists to view virtual versions of slides on computer monitors. With increasing adoption of digital pathology, laboratories have begun to validate their WSI systems for diagnostic purposes according to reference guidelines. Among these the College of American Pathologists (CAP) guideline includes three strong recommendations (SRs) and nine good practice statements (GPSs). To date, the application of WSI to cytopathology has been beyond the scope of the CAP guideline due to limited evidence. Herein we systematically reviewed the published literature on WSI validation studies in cytology. A systematic search was carried out in PubMed‐MEDLINE and Embase databases up to November 2021 to identify all publications regarding validation of WSI in cytology. Each article was reviewed to determine if SRs and/or GPSs recommended by the CAP guideline were adequately satisfied. Of 3963 retrieved articles, 25 were included. Only 4/25 studies (16%) satisfied all three SRs, with only one publication (1/25, 4%) fulfilling all three SRs and nine GPSs. Lack of a suitable validation dataset was the main missing SR (16/25, 64%) and less than a third of the studies reported intra‐observer variability data (7/25, 28%). Whilst the CAP guideline for WSI validation in clinical practice helped the widespread adoption of digital pathology, more evidence is required to routinely employ WSI for diagnostic purposes in cytopathology practice. More dedicated validation studies satisfying all SRs and/or GPSs recommended by the CAP are needed to help expedite the use of WSI for primary diagnosis in cytopathology. [ABSTRACT FROM AUTHOR]

Published
2023
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