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112 results on '"Bernava, Gianmarco"'

1. Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID-19 pandemic

Author

Nguyen, Thanh N, Haussen, Diogo C, Qureshi, Muhammad M, Yamagami, Hiroshi, Fujinaka, Toshiyuki, Mansour, Ossama Y, Abdalkader, Mohamad, Frankel, Michael, Qiu, Zhongming, Taylor, Allan, Lylyk, Pedro, Eker, Omer F, Mechtouff, Laura, Piotin, Michel, Lima, Fabricio Oliveira, Mont'Alverne, Francisco, Izzath, Wazim, Sakai, Nobuyuki, Mohammaden, Mahmoud, Al-Bayati, Alhamza R, Renieri, Leonardo, Mangiafico, Salvatore, Ozretic, David, Chalumeau, Vanessa, Ahmad, Saima, Rashid, Umair, Hussain, Syed Irteza, John, Seby, Griffin, Emma, Thornton, John, Fiorot, Jose Antonio, Rivera, Rodrigo, Hammami, Nadia, Cervantes-Arslanian, Anna M, Dasenbrock, Hormuzdiyar H, Vu, Huynh Le, Nguyen, Viet Quy, Hetts, Steven, Bourcier, Romain, Guile, Romain, Walker, Melanie, Sharma, Malveeka, Frei, Don, Jabbour, Pascal, Herial, Nabeel, Al-Mufti, Fawaz, Ozdemir, Atilla Ozcan, Aykac, Ozlem, Gandhi, Dheeraj, Chugh, Chandril, Matouk, Charles, Lavoie, Pascale, Edgell, Randall, Beer-Furlan, Andre, Chen, Michael, Killer-Oberpfalzer, Monika, Pereira, Vitor Mendes, Nicholson, Patrick, Huded, Vikram, Ohara, Nobuyuki, Watanabe, Daisuke, Shin, Dong Hun, Magalhaes, Pedro SC, Kikano, Raghid, Ortega-Gutierrez, Santiago, Farooqui, Mudassir, Abou-Hamden, Amal, Amano, Tatsuo, Yamamoto, Ryoo, Weeks, Adrienne, Cora, Elena A, Sivan-Hoffmann, Rotem, Crosa, Roberto, Möhlenbruch, Markus, Nagel, Simon, Al-Jehani, Hosam, Sheth, Sunil A, Lopez Rivera, Victor S, Siegler, James E, Sani, Achmad Fidaus, Puri, Ajit S, Kuhn, Anna Luisa, Bernava, Gianmarco, Machi, Paolo, Abud, Daniel G, Pontes-Neto, Octavio M, Wakhloo, Ajay K, Voetsch, Barbara, Raz, Eytan, Yaghi, Shadi, Mehta, Brijesh P, Kimura, Naoto, Murakami, Mamoru, Lee, Jin Soo, Hong, Ji Man, Fahed, Robert, Walker, Gregory, Hagashi, Eiji, Cordina, Steve M, and Roh, Hong Gee

Subjects
Brain Disorders, Stroke, Clinical Research, Neurosciences, COVID-19, Cross-Sectional Studies, Humans, Intracranial Aneurysm, Pandemics, Prospective Studies, Retrospective Studies, SARS-CoV-2, Subarachnoid Hemorrhage, Treatment Outcome, aneurysm, coil, haemorrhage, infection, subarachnoid, SVIN COVID-19 Registry, the Middle East North Africa Stroke and Interventional Neurotherapies Organization, Japanese Society of Vascular and Interventional Neurology Society
Abstract

BackgroundDuring the COVID-19 pandemic, decreased volumes of stroke admissions and mechanical thrombectomy were reported. The study's objective was to examine whether subarachnoid haemorrhage (SAH) hospitalisations and ruptured aneurysm coiling interventions demonstrated similar declines.MethodsWe conducted a cross-sectional, retrospective, observational study across 6 continents, 37 countries and 140 comprehensive stroke centres. Patients with the diagnosis of SAH, aneurysmal SAH, ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases, 10th Revision, codes. The 3-month cumulative volume, monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before (1 year and immediately before) and during the pandemic, defined as 1 March-31 May 2020. The prior 1-year control period (1 March-31 May 2019) was obtained to account for seasonal variation.FindingsThere was a significant decline in SAH hospitalisations, with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic, representing a relative decline of 22.5% (95% CI -24.3% to -20.7%, p

Published
2021

3. Acute Stenting and Concomitant Tirofiban Administration for the Endovascular Treatment of Acute Ischemic Stroke Related to Intracranial Artery Dissections: A Single Center Experience and Systematic Review of the Literature

Author

Bernava, Gianmarco, Meling, Torstein R., Rosi, Andrea, Hofmeister, Jeremy, Yilmaz, Hasan, Brina, Olivier, Reymond, Philippe, Muster, Michel, Corniola, Marco V., Carrera, Emmanuel, Lovblad, Karl-Olof, Kulcsar, Zsolt, and Machi, Paolo

Published
2021
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4. In vitro evaluation of how the presence of the stent retriever and microcatheter influences aspiration parameters in thrombectomy according to their position inside the aspiration catheter.

Author

Bernava, Gianmarco, Brina, Olivier, Reymond, Philippe, Rosi, Andrea, Hofmeister, Jeremy, Yilmaz, Hasan, Muster, Michel, Kulcsar, Zsolt, Lovblad, Karl-Olof, and Machi, Paolo

Subjects
*ISCHEMIC stroke, *LEVEL of aspiration, *THROMBECTOMY, *ASPIRATORS, *CATHETERS
Abstract

Background: Several variations of the combined thrombectomy technique for acute ischemic stroke using a stent retriever and aspiration catheter have been described. The aim of our study was to assess how the presence of the microcatheter and stent retriever affect the basic aspiration parameters, namely, flow rate and aspiration force, depending on their position within the aspiration catheter. Methods: Two experimental set-ups were designed to assess changes in flow rate and aspiration force according to the position of the stent retriever and microcatheter within the aspiration catheter. Results: The transition of the stent retriever and microcatheter from the distal to proximal position resulted in a progressive increase in the flow rate, but with no impact on aspiration force. Additionally, the size of the stent retriever had no significant effect on flow rate changes and the reduction in flow rate was related to the microcatheter diameter. Negative pressure generated inside the aspiration catheter impacted on its distal segment located beyond the radiopaque marker, thus leading to its partial collapse. As a consequence, the measured aspiration force was lower than the theoretical aspiration force level for all tested aspiration catheters. Conclusions: In our experimental model, the position of the stent retriever and microcatheter within the aspirator catheter affected the flow rate, but not the aspiration force. Negative pressure generated within the aspiration catheter appeared to determine a partial collapse of the distal segment that resulted in a less effective aspiration force than the theoretical aspiration force level. [ABSTRACT FROM AUTHOR]

Published
2024
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7. In vitroevaluation of how the presence of the stent retriever and microcatheter influences aspiration parameters in thrombectomy according to their position inside the aspiration catheter

Author

Bernava, Gianmarco, Brina, Olivier, Reymond, Philippe, Rosi, Andrea, Hofmeister, Jeremy, Yilmaz, Hasan, Muster, Michel, Kulcsar, Zsolt, Lovblad, Karl-Olof, and Machi, Paolo

Abstract

Background Several variations of the combined thrombectomy technique for acute ischemic stroke using a stent retriever and aspiration catheter have been described. The aim of our study was to assess how the presence of the microcatheter and stent retriever affect the basic aspiration parameters, namely, flow rate and aspiration force, depending on their position within the aspiration catheter.Methods Two experimental set-ups were designed to assess changes in flow rate and aspiration force according to the position of the stent retriever and microcatheter within the aspiration catheter.Results The transition of the stent retriever and microcatheter from the distal to proximal position resulted in a progressive increase in the flow rate, but with no impact on aspiration force. Additionally, the size of the stent retriever had no significant effect on flow rate changes and the reduction in flow rate was related to the microcatheter diameter. Negative pressure generated inside the aspiration catheter impacted on its distal segment located beyond the radiopaque marker, thus leading to its partial collapse. As a consequence, the measured aspiration force was lower than the theoretical aspiration force level for all tested aspiration catheters.Conclusions In our experimental model, the position of the stent retriever and microcatheter within the aspirator catheter affected the flow rate, but not the aspiration force. Negative pressure generated within the aspiration catheter appeared to determine a partial collapse of the distal segment that resulted in a less effective aspiration force than the theoretical aspiration force level.

Published
2024
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8. Effectiveness of the preventive administration of vasoactive amines in counterbalancing significant patient blood pressure drops following nimodipine administration during mechanical thrombectomy procedures

Author

Bernava, Gianmarco, primary, Tesoro, Rosa, additional, Boto, José, additional, Challita, Myriam, additional, Rosi, Andrea, additional, Hofmeister, Jeremy, additional, Yilmaz, Hasan, additional, Carrera, Emmanuel, additional, Brina, Olivier, additional, Reymond, Philippe, additional, Muster, Michel, additional, Kulcsar, Zsolt, additional, Lovblad, Karl-Olof, additional, and Machi, Paolo, additional

Published
2023
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14. Endovascular treatment strategies for simultaneous bilateral anterior circulation occlusions in acute ischemic stroke: A single-center experience and systematic review of the literature

Author

Bernava, Gianmarco, primary, Botti, Paul, additional, Rosi, Andrea, additional, Hofmeister, Jeremy, additional, Yilmaz, Hasan, additional, Carrera, Emmanuel, additional, Brina, Olivier, additional, Reymond, Philippe, additional, Muster, Michel, additional, Kulcsar, Zsolt, additional, Lovblad, Karl-Olof, additional, and Machi, Paolo, additional

Published
2023
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15. Global Impact of the COVID-19 Pandemic on Stroke Volumes and Cerebrovascular Events: A 1-Year Follow-up

Author

Society of Vascular and Interventional Neurology (US), Nguyen, Thanh N., Qureshi, Muhammad M., Klein, Piers, Yamagami, Hiroshi, Mikulik, Robert, Czlonkowska, Anna, Abdalkader, Mohamad, Sedova, Petra, Sathya, Anvitha, Lo, Hannah C., Mansour, Ossama Yassin, Vanguru, Husitha Reddy, Lesaine, Emilie, Tsivgoulis, Georgios, Loochtan, Aaron I., Demeestere, Jelle, Uchino, Ken, Inoa, Violiza, Goyal, Nitin, Charidimou, Andreas, Siegler, James E., Yaghi, Shadi, Aguiar de Sousa, Diana, Mohammaden, Mahmoud H., Haussen, Diogo C., Kristoffersen, Espen Saxhaug, Lereis, Virginia Pujol, Scollo, Sergio Daniel, Campbell, Bruce C. V., Ma, Alice, Thomas, James Orton, Parsons, Mark W., Singhal, Shaloo, Slater, Lee-Anne, Tomazini Martins, Rodrigo, Enzinger, Chris, Gattringer, Thomas, Rahman, Aminur, Bonnet, Thomas, Ligot, Noemie, De Raedt, Sylvie, Lemmens, Robin, Vanacker, Peter, Vandervorst, Fenne, Conforto, Adriana Bastos, Hidalgo, Raquel C. T., Neves, Luciana de Oliveira, Martins, Rodrigo Targa, Mora Cuervo, Daissy Liliana, Rebello, Leticia C., Santiago, Igor Bessa, Silva, Isabelle Lameirinhas da, Sakelarova, Teodora, Kalpachki, Rosen, Alexiev, Filip, Catanese, Luciana, Cora, Elena Adela, Goyal, Mayank, Hill, Michael D., Kelly, Michael E., Khosravani, Houman, Lavoie, Pascale, Peeling, Lissa, Pikula, Aleksandra, Rivera, Rodrigo, Chen, Hui-Sheng, Chen, Yimin, Huo, Xiaochuan, Miao, Zhongrong, Yang, Shuiquan, Bedekovic, Marina Roje, Bralic, Marina, Budincevic, Hrvoje, Corredor-Quintero, Ángel Basilio, Lara-Sarabia, Osvaldo E., Cabal, Martin, Tenora, Dusan, Fibrich, Petr, Herzig, Roman, Hlaváčová, Helena, Hrabanovska, Emanuela, Hlinovsky, David, Jurak, Lubomir, Kadlcikova, Jana, Karpowicz, Igor, Klecka, Lukas, Kovar, Martin, Lauer, David, Neumann, Jiri, Palouskova, Hana, Reiser, Martin, Rekova, Petra, Rohan, Vladimir, Skoda, Ondrej, Škorňa, Miroslav, Sobotková, Lenka, Sramek, Martin, Zakova, Lenka, Christensen, Hanne, Drenck, Nicolas, Iversen, Helle Klingenberg, Truelsen, Thomas Clement, Wienecke, Troels, Sobh, Khalid, Ylikotila, Pauli, Alpay, Kemal, Strbian, Daniel, Bernady, Patricia, Casenave, Philippe, Dan, Maria, Faucheux, Jean-Marc, Gentric, Jean-Christophe, Magro, Elsa, Sabben, Candice, Reiner, Peggy, Rouanet, Francois, Bohmann, Ferdinand O., Boskamp, Stefan, Mbroh, Joshua, Nagel, Simon, Nolte, Christian H, Ringleb, Peter A., Rosenkranz, Michael, Poli, Sven, Thomalla, Götz, Karapanayiotides, Theodoros, Koutroulou, Ioanna, Kargiotis, Odysseas, Palaiodimou, Lina, Barrientos Guerra, José Domingo, Huded, Vikram, Menon, Bindu, Nagendra, Shashank, Prajapati, Chintan, Sylaja, P. N., Krishna Pramana, Nyoman Angga, Sani, Achmad Firdaus, Ghoreishi, Abdoreza, Farhoudi, Mehdi, Hokmabadi, Elyar Sadeghi, Raya, Tariq Abu, Kalmanovich, Shani Avnery, Ronen, Levite, Sabetay, Sergiu Ionut, Acampa, Maurizio, Adami, Alessandro, Castellan, Lucio, Longoni, Marco, Ornello, Raffaele, Renieri, Leonardo, Bigliani, Claudia Rolla, Romoli, Michele, Sacco, Simona, Salmaggi, Andrea, Sangalli, Davide, Zini, Andrea, Doijiri, Ryosuke, Fukuda, Hiroki, Fujinaka, Toshiyuki, Fujita, Kyohei, Imamura, Hirotoshi, Sakai, Nobuyuki, Kanamaru, Takuya, Kimura, Naoto, Kono, Ryuhei, Miyake, Kosuke, Sakaguchi, Manabu, Sakai, Kenichiro, Sonoda, Kazutaka, Todo, Kenichi, Miyashita, Fumio, Tokuda, Naoki, Matsumaru, Yuji, Matsumoto, Shoji, Ohara, Nobuyuki, Shindo, Seigo, Takenobu, Yohei, Yoshimoto, Takeshi, Toyoda, Kazunori, Uwatoko, Takeshi, Yagita, Yoshiki, Yamada, Takehiro, Yamamoto, Nobuaki, Yamamoto, Ryoo, Yazawa, Yukako, Sugiura, Yuri, Waweru, Peter Kuria, Baek, Jang-Hyun, Lee, Si Baek, Seo, Kwon-Duk, Sohn, Sung-Il, Arsovska, Anita Ante, Chan, Yong Chieh, Wan Zaidi, Wan Asyraf, Jaafar, Ainul Syahrilfazli, Gongora-Rivera, Fernando, Martinez-Marino, Manuel, Infante-Valenzuela, Adrian, Groppa, Stanislav, Leahu, Pavel, Coutinho, Jonathan M, Rinkel, Leon A., Dippel, Diederik W. J., Dam-Nolen, Dianne H. K. van, Ranta, Annemarei, Wu, Teddy Y., Adebayo, Tajudeen Temitayo, Bello, Abiodun H., Nwazor, Ernest Okwundu, Sunmonu, Taofiki Ajao, Wahab, Kolawole Wasiu, Ronning, Ole Morten, Sandset, Else Charlotte, Al Hashmi, Amal M., Ahmad, Saima, Rashid, Umair, Rodriguez-Kadota, Liliana, Vences, Miguel Ángel, Yalung, Patrick Matic, Hao Dy, Jon Stewart, Pineda-Franks, Maria Carissa, Co, Christian Oliver, Brola, Waldemar, Debiec, Aleksander, Dorobek, Malgorzata, Karlinski, Michal Adam, Labuz-Roszak, Beata M., Lasek-Bal, Anetta, Sienkiewicz-Jarosz, Halina, Staszewski, Jacek, Sobolewski, Piotr, Wiacek, Marcin, Zielinska-Turek, Justyna, Araujo, Andre Pinho, Rocha, Mariana, Castro, Pedro, Cruz, Vitor Tedim, Ferreira, Paulo Venancio, Ferreira, Patricia, Nunes, Ana Paiva, Fonseca, Luisa, Marto, João Pedro, Pinho E Melo, Teresa, Rodrigues, Miguel, Silva, M. Luis, Dimitriade, Adela, Falup-Pecurariu, Cristian, Hamid, May Adel, Venketasubramanian, Narayanaswamy, Krastev, Georgi, Mako, Miroslav, Ayo-Martin, Oscar, Hernández-Fernández, Francisco, Blasco, Jordi, Rodríguez-Vázquez, Alejandro, Cruz-Culebras, Antonio, Moniche, Francisco, Montaner, Joan, Pérez-Sánchez, Soledad, García Sánchez, María Jesús, Guillán Rodríguez, Marta, Jood, Katarina, Nordanstig, Annika, Mazya, Michael V., Moreira, Tiago T. P., Bernava, Gianmarco, Beyeler, Morin, Bolognese, Manuel, Carrera, Emmanuel, Dobrocky, Tomas, Karwacki, Grzegorz Marek, Keller, Emanuela, Hsieh, Chang Yang, Boonyakarnkul, Surawan, Churojana, Anchalee, Aykac, Ozlem, Ozdemir, Atilla Ã-Zcan, Bajrami, Arsida, Senadim, Songul, Hussain, Syed Irteza, John, Seby, Banerjee, Soma, Kwan, Joseph, Krishnan, Kailash, Lenthall, Robert, Matthews, Ashok, Wong, Ken, Zhang, Liqun, Altschul, Dorothea, Asif, Kaiz S., Bahiru, Zeelalem, Below, Kristine, Biller, José, Ruland, Sean, Chaudry, Saqib A., Chen, Michael, Chebl, Alex, Cibulka, Jackie, Cistrunk, Leon, Clark, Judith, Colasurdo, Marco, Czap, Alexandra, de Havenon, Adam, D'Amato, Salvatore, Dharmadhikari, Sushrut, Grimmett, Kasey B., Dmytriw, Adam A., Etherton, Mark R., Ezepue, Chizoba, Farooqui, Mudassir, Feske, Steven K., Fink, Lauren, Gasimova, Ulviyya, Guzik, Amy K., Hakemi, Maryam, Hovingh, Majesta, Khan, Muhib, Jillela, Dinesh, Kan, Peter T., Khatri, Rakesh, Khawaja, Ayaz M., Khoury, Naim N., Kiley, Nicole L., Kim, Benny S., Kolikonda, Murali K., Kuhn, Anna Luisa, Lara, Stephanie, Linares, Guillermo, Linfante, Italo, Lukovits, Timothy G., Lycan, Sarah, Male, Shailesh S., Maali, Laith, Mancin, John, Masoud, Hesham, Mohamed, Ghada A., Monteiro, Andre, Nahab, Fadi, Nalleballe, Krishna, Ortega-Gutiérrez, Santiago, Puri, Ajit S, Radaideh, Yazan, Rahangdale, Rahul H., Rai, Ansaar, Ramakrishnan, Pankajavalli, Reddy, Aravind B., Rojas-Soto, Diana M., Romero, José Rafael, Rost, Natalia S., Rothstein, Aaron, Omran, Setareh Salehi, Sheth, Sunil A., Siddiqui, Adnan H., Starosciak, Amy K., Tarlov, Nicholas E., Taylor, Robert A., Wang, Michael J., Wolfe, Jared, Wong, Ka-Ho, Le, Huynh Vu, Nguyen, Quy Viet, Pham, Thong Nhu, Nguyen, Trung Thanh, Phan, Hoang Thi, Ton, Mai Duy, Fischer, Urs, Michel, Patrik, Strambo, Davide, Martins, Sheila O., Zaidat, Osama O., Nogueira, Raul G., Society of Vascular and Interventional Neurology (US), Nguyen, Thanh N., Qureshi, Muhammad M., Klein, Piers, Yamagami, Hiroshi, Mikulik, Robert, Czlonkowska, Anna, Abdalkader, Mohamad, Sedova, Petra, Sathya, Anvitha, Lo, Hannah C., Mansour, Ossama Yassin, Vanguru, Husitha Reddy, Lesaine, Emilie, Tsivgoulis, Georgios, Loochtan, Aaron I., Demeestere, Jelle, Uchino, Ken, Inoa, Violiza, Goyal, Nitin, Charidimou, Andreas, Siegler, James E., Yaghi, Shadi, Aguiar de Sousa, Diana, Mohammaden, Mahmoud H., Haussen, Diogo C., Kristoffersen, Espen Saxhaug, Lereis, Virginia Pujol, Scollo, Sergio Daniel, Campbell, Bruce C. V., Ma, Alice, Thomas, James Orton, Parsons, Mark W., Singhal, Shaloo, Slater, Lee-Anne, Tomazini Martins, Rodrigo, Enzinger, Chris, Gattringer, Thomas, Rahman, Aminur, Bonnet, Thomas, Ligot, Noemie, De Raedt, Sylvie, Lemmens, Robin, Vanacker, Peter, Vandervorst, Fenne, Conforto, Adriana Bastos, Hidalgo, Raquel C. T., Neves, Luciana de Oliveira, Martins, Rodrigo Targa, Mora Cuervo, Daissy Liliana, Rebello, Leticia C., Santiago, Igor Bessa, Silva, Isabelle Lameirinhas da, Sakelarova, Teodora, Kalpachki, Rosen, Alexiev, Filip, Catanese, Luciana, Cora, Elena Adela, Goyal, Mayank, Hill, Michael D., Kelly, Michael E., Khosravani, Houman, Lavoie, Pascale, Peeling, Lissa, Pikula, Aleksandra, Rivera, Rodrigo, Chen, Hui-Sheng, Chen, Yimin, Huo, Xiaochuan, Miao, Zhongrong, Yang, Shuiquan, Bedekovic, Marina Roje, Bralic, Marina, Budincevic, Hrvoje, Corredor-Quintero, Ángel Basilio, Lara-Sarabia, Osvaldo E., Cabal, Martin, Tenora, Dusan, Fibrich, Petr, Herzig, Roman, Hlaváčová, Helena, Hrabanovska, Emanuela, Hlinovsky, David, Jurak, Lubomir, Kadlcikova, Jana, Karpowicz, Igor, Klecka, Lukas, Kovar, Martin, Lauer, David, Neumann, Jiri, Palouskova, Hana, Reiser, Martin, Rekova, Petra, Rohan, Vladimir, Skoda, Ondrej, Škorňa, Miroslav, Sobotková, Lenka, Sramek, Martin, Zakova, Lenka, Christensen, Hanne, Drenck, Nicolas, Iversen, Helle Klingenberg, Truelsen, Thomas Clement, Wienecke, Troels, Sobh, Khalid, Ylikotila, Pauli, Alpay, Kemal, Strbian, Daniel, Bernady, Patricia, Casenave, Philippe, Dan, Maria, Faucheux, Jean-Marc, Gentric, Jean-Christophe, Magro, Elsa, Sabben, Candice, Reiner, Peggy, Rouanet, Francois, Bohmann, Ferdinand O., Boskamp, Stefan, Mbroh, Joshua, Nagel, Simon, Nolte, Christian H, Ringleb, Peter A., Rosenkranz, Michael, Poli, Sven, Thomalla, Götz, Karapanayiotides, Theodoros, Koutroulou, Ioanna, Kargiotis, Odysseas, Palaiodimou, Lina, Barrientos Guerra, José Domingo, Huded, Vikram, Menon, Bindu, Nagendra, Shashank, Prajapati, Chintan, Sylaja, P. N., Krishna Pramana, Nyoman Angga, Sani, Achmad Firdaus, Ghoreishi, Abdoreza, Farhoudi, Mehdi, Hokmabadi, Elyar Sadeghi, Raya, Tariq Abu, Kalmanovich, Shani Avnery, Ronen, Levite, Sabetay, Sergiu Ionut, Acampa, Maurizio, Adami, Alessandro, Castellan, Lucio, Longoni, Marco, Ornello, Raffaele, Renieri, Leonardo, Bigliani, Claudia Rolla, Romoli, Michele, Sacco, Simona, Salmaggi, Andrea, Sangalli, Davide, Zini, Andrea, Doijiri, Ryosuke, Fukuda, Hiroki, Fujinaka, Toshiyuki, Fujita, Kyohei, Imamura, Hirotoshi, Sakai, Nobuyuki, Kanamaru, Takuya, Kimura, Naoto, Kono, Ryuhei, Miyake, Kosuke, Sakaguchi, Manabu, Sakai, Kenichiro, Sonoda, Kazutaka, Todo, Kenichi, Miyashita, Fumio, Tokuda, Naoki, Matsumaru, Yuji, Matsumoto, Shoji, Ohara, Nobuyuki, Shindo, Seigo, Takenobu, Yohei, Yoshimoto, Takeshi, Toyoda, Kazunori, Uwatoko, Takeshi, Yagita, Yoshiki, Yamada, Takehiro, Yamamoto, Nobuaki, Yamamoto, Ryoo, Yazawa, Yukako, Sugiura, Yuri, Waweru, Peter Kuria, Baek, Jang-Hyun, Lee, Si Baek, Seo, Kwon-Duk, Sohn, Sung-Il, Arsovska, Anita Ante, Chan, Yong Chieh, Wan Zaidi, Wan Asyraf, Jaafar, Ainul Syahrilfazli, Gongora-Rivera, Fernando, Martinez-Marino, Manuel, Infante-Valenzuela, Adrian, Groppa, Stanislav, Leahu, Pavel, Coutinho, Jonathan M, Rinkel, Leon A., Dippel, Diederik W. J., Dam-Nolen, Dianne H. K. van, Ranta, Annemarei, Wu, Teddy Y., Adebayo, Tajudeen Temitayo, Bello, Abiodun H., Nwazor, Ernest Okwundu, Sunmonu, Taofiki Ajao, Wahab, Kolawole Wasiu, Ronning, Ole Morten, Sandset, Else Charlotte, Al Hashmi, Amal M., Ahmad, Saima, Rashid, Umair, Rodriguez-Kadota, Liliana, Vences, Miguel Ángel, Yalung, Patrick Matic, Hao Dy, Jon Stewart, Pineda-Franks, Maria Carissa, Co, Christian Oliver, Brola, Waldemar, Debiec, Aleksander, Dorobek, Malgorzata, Karlinski, Michal Adam, Labuz-Roszak, Beata M., Lasek-Bal, Anetta, Sienkiewicz-Jarosz, Halina, Staszewski, Jacek, Sobolewski, Piotr, Wiacek, Marcin, Zielinska-Turek, Justyna, Araujo, Andre Pinho, Rocha, Mariana, Castro, Pedro, Cruz, Vitor Tedim, Ferreira, Paulo Venancio, Ferreira, Patricia, Nunes, Ana Paiva, Fonseca, Luisa, Marto, João Pedro, Pinho E Melo, Teresa, Rodrigues, Miguel, Silva, M. Luis, Dimitriade, Adela, Falup-Pecurariu, Cristian, Hamid, May Adel, Venketasubramanian, Narayanaswamy, Krastev, Georgi, Mako, Miroslav, Ayo-Martin, Oscar, Hernández-Fernández, Francisco, Blasco, Jordi, Rodríguez-Vázquez, Alejandro, Cruz-Culebras, Antonio, Moniche, Francisco, Montaner, Joan, Pérez-Sánchez, Soledad, García Sánchez, María Jesús, Guillán Rodríguez, Marta, Jood, Katarina, Nordanstig, Annika, Mazya, Michael V., Moreira, Tiago T. P., Bernava, Gianmarco, Beyeler, Morin, Bolognese, Manuel, Carrera, Emmanuel, Dobrocky, Tomas, Karwacki, Grzegorz Marek, Keller, Emanuela, Hsieh, Chang Yang, Boonyakarnkul, Surawan, Churojana, Anchalee, Aykac, Ozlem, Ozdemir, Atilla Ã-Zcan, Bajrami, Arsida, Senadim, Songul, Hussain, Syed Irteza, John, Seby, Banerjee, Soma, Kwan, Joseph, Krishnan, Kailash, Lenthall, Robert, Matthews, Ashok, Wong, Ken, Zhang, Liqun, Altschul, Dorothea, Asif, Kaiz S., Bahiru, Zeelalem, Below, Kristine, Biller, José, Ruland, Sean, Chaudry, Saqib A., Chen, Michael, Chebl, Alex, Cibulka, Jackie, Cistrunk, Leon, Clark, Judith, Colasurdo, Marco, Czap, Alexandra, de Havenon, Adam, D'Amato, Salvatore, Dharmadhikari, Sushrut, Grimmett, Kasey B., Dmytriw, Adam A., Etherton, Mark R., Ezepue, Chizoba, Farooqui, Mudassir, Feske, Steven K., Fink, Lauren, Gasimova, Ulviyya, Guzik, Amy K., Hakemi, Maryam, Hovingh, Majesta, Khan, Muhib, Jillela, Dinesh, Kan, Peter T., Khatri, Rakesh, Khawaja, Ayaz M., Khoury, Naim N., Kiley, Nicole L., Kim, Benny S., Kolikonda, Murali K., Kuhn, Anna Luisa, Lara, Stephanie, Linares, Guillermo, Linfante, Italo, Lukovits, Timothy G., Lycan, Sarah, Male, Shailesh S., Maali, Laith, Mancin, John, Masoud, Hesham, Mohamed, Ghada A., Monteiro, Andre, Nahab, Fadi, Nalleballe, Krishna, Ortega-Gutiérrez, Santiago, Puri, Ajit S, Radaideh, Yazan, Rahangdale, Rahul H., Rai, Ansaar, Ramakrishnan, Pankajavalli, Reddy, Aravind B., Rojas-Soto, Diana M., Romero, José Rafael, Rost, Natalia S., Rothstein, Aaron, Omran, Setareh Salehi, Sheth, Sunil A., Siddiqui, Adnan H., Starosciak, Amy K., Tarlov, Nicholas E., Taylor, Robert A., Wang, Michael J., Wolfe, Jared, Wong, Ka-Ho, Le, Huynh Vu, Nguyen, Quy Viet, Pham, Thong Nhu, Nguyen, Trung Thanh, Phan, Hoang Thi, Ton, Mai Duy, Fischer, Urs, Michel, Patrik, Strambo, Davide, Martins, Sheila O., Zaidat, Osama O., and Nogueira, Raul G.

Abstract

Background and Objectives: Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), IVT, and mechanical thrombectomy over a 1-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020)., Methods: We conducted a longitudinal retrospective study across 6 continents, 56 countries, and 275 stroke centers. We collected volume data for COVID-19 admissions and 4 stroke metrics: ischemic stroke admissions, ICH admissions, IVT treatments, and mechanical thrombectomy procedures. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases., Results: There were 148,895 stroke admissions in the 1 year immediately before compared with 138,453 admissions during the 1-year pandemic, representing a 7% decline (95% CI [95% CI 7.1–6.9]; p < 0.0001). ICH volumes declined from 29,585 to 28,156 (4.8% [5.1–4.6]; p < 0.0001) and IVT volume from 24,584 to 23,077 (6.1% [6.4–5.8]; p < 0.0001). Larger declines were observed at high-volume compared with low-volume centers (all p < 0.0001). There was no significant change in mechanical thrombectomy volumes (0.7% [0.6–0.9]; p = 0.49). Stroke was diagnosed in 1.3% [1.31–1.38] of 406,792 COVID-19 hospitalizations. SARS-CoV-2 infection was present in 2.9% ([2.82–2.97], 5,656/195,539) of all stroke hospitalizations., Discussion: There was a global decline and shift to lower-volume centers of stroke admission volumes, ICH volumes, and IVT volumes during the 1st year of the COVID-19 pandemic compared with the prior year. Mechanical thrombectomy volumes were preserved. These results suggest preservation in the stroke care of higher severity of disease through the first pandemic year., Trial Registration Information: This study is registered under NCT04934020.

Published
2023

16. Endovascular treatment strategies for simultaneous bilateral anterior circulation occlusions in acute ischemic stroke: A single-center experience and systematic review of the literature

Author

Bernava, Gianmarco; https://orcid.org/0000-0003-2037-5558, Botti, Paul; https://orcid.org/0000-0002-2268-1121, Rosi, Andrea; https://orcid.org/0000-0003-0286-2889, Hofmeister, Jeremy; https://orcid.org/0000-0002-0071-8499, Yilmaz, Hasan, Carrera, Emmanuel, Brina, Olivier, Reymond, Philippe, Muster, Michel, Kulcsar, Zsolt; https://orcid.org/0000-0002-6805-5150, Lovblad, Karl-Olof, Machi, Paolo, Bernava, Gianmarco; https://orcid.org/0000-0003-2037-5558, Botti, Paul; https://orcid.org/0000-0002-2268-1121, Rosi, Andrea; https://orcid.org/0000-0003-0286-2889, Hofmeister, Jeremy; https://orcid.org/0000-0002-0071-8499, Yilmaz, Hasan, Carrera, Emmanuel, Brina, Olivier, Reymond, Philippe, Muster, Michel, Kulcsar, Zsolt; https://orcid.org/0000-0002-6805-5150, Lovblad, Karl-Olof, and Machi, Paolo

Abstract

BACKGROUND Bilateral and simultaneous occlusion of the anterior circulation is a rare event in patients with acute ischemic stroke. Although endovascular treatment is feasible and safe, the endovascular strategy to be used remains a subject of debate. OBJECTIVE To assess the different endovascular strategies proposed for the treatment of a bilateral, simultaneous anterior circulation occlusion following acute ischemic stroke. METHODS We present a retrospective study of the clinical and radiological records of all patients with a bilateral, simultaneous anterior circulation occlusion treated at our center between January 2019 and December 2022. Following the PRISMA guidelines, we also conducted a systematic review of the literature. RESULTS Two patients with a bilateral and simultaneous middle cerebral artery occlusion were treated at our center during the study period. A TICI score ≥2b was obtained in 4 out of 4 occlusions. Modified Rankin Scale (mRS) at 90 days was 0 and 4, respectively. The literature review retrieved reports on 22 patients. The most frequent bilateral occlusion sites were internal carotid artery-middle cerebral artery. The clinical presentation was severe in most patients. A combined thrombectomy technique proved to have the highest number of first-pass recanalization. A TICI ≥2b was obtained in 95% of patients and an mRS ≤2 was found in 31.8% of patients. CONCLUSIONS In patients with bilateral and simultaneous occlusion of the anterior circulation, endovascular treatment using a combined technique appears to be rapid and effective. The clinical evolution of this patient population strongly depends on the severity of the onset symptoms.

Published
2023

17. Effectiveness of the preventive administration of vasoactive amines in counterbalancing significant patient blood pressure drops following nimodipine administration during mechanical thrombectomy procedures

Author

Bernava, Gianmarco; https://orcid.org/0000-0003-2037-5558, Tesoro, Rosa, Boto, José, Challita, Myriam, Rosi, Andrea, Hofmeister, Jeremy; https://orcid.org/0000-0002-0071-8499, Yilmaz, Hasan, Carrera, Emmanuel, Brina, Olivier, Reymond, Philippe, Muster, Michel, Kulcsar, Zsolt, Lovblad, Karl-Olof, Machi, Paolo, Bernava, Gianmarco; https://orcid.org/0000-0003-2037-5558, Tesoro, Rosa, Boto, José, Challita, Myriam, Rosi, Andrea, Hofmeister, Jeremy; https://orcid.org/0000-0002-0071-8499, Yilmaz, Hasan, Carrera, Emmanuel, Brina, Olivier, Reymond, Philippe, Muster, Michel, Kulcsar, Zsolt, Lovblad, Karl-Olof, and Machi, Paolo

Abstract

BACKGROUND Focal vasospasm (FV) of the occluded vessel can occur during the endovascular treatment of acute ischemic stroke (AIS). Nimodipine is commonly used to treat vasospasm and can play a role in distinguishing it from artery narrowing due to iatrogenic dissection or residual clot. However, nimodipine administration can result in arterial hypotension and subsequent enlargement of the ischemic core. OBJECTIVE To assess the efficacy of preventive and continuous vasoactive amine infusion to counterbalance nimodipine-induced hypotension. METHODS We reviewed data from a prospective registry of patients treated for AIS between January 2019 and January 2022 who were administered nimodipine. All patients were equipped with an arterial cannula for invasive blood pressure measurement and given vasoactive amines preemptively before general anesthesia and throughout the procedure. Data obtained from invasive monitoring of mean arterial blood pressure (MABP) in a time-lapse of 25 min before and after nimodipine administration were analyzed. RESULTS MABP significantly decreased after nimodipine administration but remained within the recommended range (81.79 ± 0.49 mmHg). Nimodipine was effective in reducing FV caused by stent retriever passage in 76.3% of cases. Furthermore, it proved valuable in diagnosing iatrogenic dissection (9.2%), residual clot (10.5%), or intracranial stenosis (4%). CONCLUSIONS Infusion of vasoactive amines effectively counteracted the intraarterial nimodipine effect, thus avoiding frank arterial hypotension during endovascular treatment. Nimodipine has been useful in differentiating the diagnosis of FV resulting from mechanical thrombectomy and other potential causes, such as iatrogenic dissection or residual clot.

Published
2023

18. Global Impact of the COVID-19 Pandemic on Cerebral Venous Thrombosis and Mortality

Author

Nguyen, Thanh N, Qureshi, Muhammad M, Klein, Piers, Yamagami, Hiroshi, Abdalkader, Mohamad, Mikulik, Robert, Sathya, Anvitha, Mansour, Ossama Yassin, Czlonkowska, Anna, Hannah, Lo, Field, Thalia S, Charidimou, Andreas, Banerjee, Soma, Yaghi, Shadi, Siegler, James E, Sedova, Petra, Kwan, Joseph, de Sousa, Diana Aguiar, Demeestere, Jelle, Inoa, Violiza, Omran, Setareh Salehi, Zhang, Liqun, Michel, Patrik, Strambo, Davide, Marto, João Pedro, Nogueira, Raul G, Kristoffersen, Espen Saxhaug, Tsivgoulis, Georgios, Lereis, Virginia Pujol, Alice, Ma, Enzinger, Christian, Gattringer, Thomas, Rahman, Aminur, Bonnet, Thomas, Ligot, Noémie, De Raedt, Sylvie, Lemmens, Robin, Vanacker, Peter, Vandervorst, Fenne, Conforto, Adriana Bastos, Hidalgo, Raquel C T, Mora Cuervo, Daissy Liliana, de Oliveira Neves, Luciana, Lameirinhas da Silva, Isabelle, Martíns, Rodrigo Targa, Rebello, Letícia C, Santiago, Igor Bessa, Sadelarova, Teodora, Kalpachki, Rosen, Alexiev, Filip, Cora, Elena Adela, Kelly, Michael E, Peeling, Lissa, Pikula, Aleksandra, Chen, Hui-Sheng, Chen, Yimin, Yang, Shuiquan, Roje Bedekovic, Marina, Čabal, Martin, Tenora, Dusan, Fibrich, Petr, Dušek, Pavel, Hlaváčová, Helena, Hrabanovska, Emanuela, Jurák, Lubomír, Kadlčíková, Jana, Karpowicz, Igor, Klečka, Lukáš, Kovář, Martin, Neumann, Jiří, Paloušková, Hana, Reiser, Martin, Rohan, Vladimir, Šimůnek, Libor, Skoda, Ondreij, Škorňa, Miroslav, Šrámek, Martin, Drenck, Nicolas, Sobh, Khalid, Lesaine, Emilie, Sabben, Candice, Reiner, Peggy, Rouanet, Francois, Strbian, Daniel, Boskamp, Stefan, Mbroh, Joshua, Nagel, Simon, Rosenkranz, Michael, Poli, Sven, Thomalla, Götz, Karapanayiotides, Theodoros, Koutroulou, Ioanna, Kargiotis, Odysseas, Palaiodimou, Lina, Barrientos Guerra, José Dominguo, Huded, Vikram, Nagendra, Shashank, Prajapati, Chintan, Sylaja, P N, Sani, Achmad Firdaus, Ghoreishi, Abdoreza, Farhoudi, Mehdi, Sadeghi Hokmabadi, Elyar, Hashemilar, Mazyar, Sabetay, Sergiu Ionut, Rahal, Fadi, Acampa, Maurizio, Adami, Alessandro, Longoni, Marco, Ornello, Raffaele, Renieri, Leonardo, Romoli, Michele, Sacco, Simona, Salmaggi, Andrea, Sangalli, Davide, Zini, Andrea, Sakai, Kenichiro, Fukuda, Hiroki, Fujita, Kyohei, Imamura, Hirotoshi, Kosuke, Miyake, Sakaguchi, Manabu, Sonoda, Kazutaka, Matsumaru, Yuji, Ohara, Nobuyuki, Shindo, Seigo, Takenobu, Yohei, Yoshimoto, Takeshi, Toyoda, Kazunori, Uwatoko, Takeshi, Sakai, Nobuyuki, Yamamoto, Nobuaki, Yamamoto, Ryoo, Yazawa, Yukako, Sugiura, Yuri, Baek, Jang-Hyun, Lee, Si Baek, Seo, Kwon-Duk, Sohn, Sung-Il, Lee, Jin Soo, Arsovska, Anita Ante, Chieh, Chan Yong, Wan Zaidi, Wan Asyraf, Wan Yahya, Wan Nur Nafisah, Gongora-Rivera, Fernando, Martinez-Marino, Manuel, Infante-Valenzuela, Adrian, Dippel, Diederik, van Dam-Nolen, Dianne H K, Teddy Y, Wu, Punter, Martin, Adebayo, Tajudeen Temitayo, Bello, Abiodun H, Sunmonu, Taofiki Ajao, Wahab, Kolawole Wasiu, Sundseth, Antje, Al Hashmi, Amal M, Ahmad, Saima, Rashid, Umair, Rodriguez-Kadota, Liliana, Vences, Miguel Ángel, Yalung, Patrick Matic, Jon Stewart Hao, Dy, Brola, Waldemar, Dębiec, Aleksander, Dorobek, Malgorzata, Karlinski, Michal Adam, Labuz-Roszak, Beata M, Lasek-Bal, Anetta, Sienkiewicz-Jarosz, Halina, Staszewski, Jacek, Sobolewski, Piotr, Wiącek, Marcin, Zielinska-Turek, Justyna, Araújo, André Pinho, Rocha, Mariana, Castro, Pedro, Ferreira, Patricia, Nunes, Ana Paiva, Fonseca, Luísa, Pinho E Melo, Teresa, Rodrigues, Miguel, Silva, M Luis, Ciopleias, Bogdan, Dimitriade, Adela, Falup-Pecurariu, Cristian, Hamid, May Adel, Venketasubramanian, Narayanaswamy, Krastev, Georgi, Haring, Jozef, Ayo-Martin, Oscar, Hernandez-Fernandez, Francisco, Blasco, Jordi, Rodríguez-Vázquez, Alejandro, Cruz-Culebras, Antonio, Moniche, Francisco, Montaner, Joan, Perez-Sanchez, Soledad, García Sánchez, María Jesús, Guillán Rodríguez, Marta, Bernava, Gianmarco, Bolognese, Manuel, Carrera, Emmanuel, Churojana, Anchalee, Aykac, Ozlem, Özdemir, Atilla Özcan, Bajrami, Arsida, Senadim, Songul, Hussain, Syed I, John, Seby, Krishnan, Kailash, Lenthall, Robert, Asif, Kaiz S, Below, Kristine, Biller, Jose, Chen, Michael, Chebl, Alex, Colasurdo, Marco, Czap, Alexandra, de Havenon, Adam H, Dharmadhikari, Sushrut, Eskey, Clifford J, Farooqui, Mudassir, Feske, Steven K, Goyal, Nitin, Grimmett, Kasey B, Guzik, Amy K, Haussen, Diogo C, Hovingh, Majesta, Jillela, Dinesh, Kan, Peter T, Khatri, Rakesh, Khoury, Naim N, Kiley, Nicole L, Kolikonda, Murali K, Lara, Stephanie, Grace, Li, Linfante, Italo, Loochtan, Aaron I, Lopez, Carlos D, Lycan, Sarah, Male, Shailesh S, Nahab, Fadi, Maali, Laith, Masoud, Hesham E, Min, Jiangyong, Orgeta-Gutierrez, Santiago, Mohamed, Ghada A, Mohammaden, Mahmoud, Nalleballe, Krishna, Radaideh, Yazan, Ramakrishnan, Pankajavalli, Rayo-Taranto, Bliss, Rojas-Soto, Diana M, Ruland, Sean, Simpkins, Alexis N, Sheth, Sunil A, Starosciak, Amy K, Tarlov, Nicholas E, Taylor, Robert A, Voetsch, Barbara, Zhang, Linda, Duong, Hai Quang, Dao, Viet-Phuong, Huynh Vu, Le, Pham, Thong Nhu, Ton, Mai Duy, Tran, Anh Duc, Zaidat, Osama O, Machi, Paolo, Dirren, Elisabeth, Rodríguez Fernández, Claudio, Escartín López, Jorge, Fernández Ferro, Jose Carlos, Mohammadzadeh, Niloofar, Suryadevara, Neil C, de la Cruz Fernández, Beatriz, Bessa, Filipe, Jancar, Nina, Brady, Megan, Scozzari, Dawn, SVIN COVID-19 Global COVID Stroke Registry, Neurology, Radiology & Nuclear Medicine, Society of Vascular and Interventional Neurology, Nguyen, Thanh N., Nogueira, Raul G., Clinical sciences, Neuroprotection & Neuromodulation, Biology, Neurologian yksikkö, HUS Neurocenter, and Helsinki University Hospital Area

Subjects
Stroke, Vaccine-induced immune thrombotic thrombocytopenia, SDG 3 - Good Health and Well-being, Cerebral venous thrombosis, SARS-CoV-2, 3112 Neurosciences, COVID-19, Mortality, Neurology (clinical), Cardiology and Cardiovascular Medicine, 3124 Neurology and psychiatry
Abstract

[Background and Purpose] Recent studies suggested an increased incidence of cerebral venous thrombosis (CVT) during the coronavirus disease 2019 (COVID-19) pandemic. We evaluated the volume of CVT hospitalization and in-hospital mortality during the 1st year of the COVID-19 pandemic compared to the preceding year., [Methods] We conducted a cross-sectional retrospective study of 171 stroke centers from 49 countries. We recorded COVID-19 admission volumes, CVT hospitalization, and CVT in-hospital mortality from January 1, 2019, to May 31, 2021. CVT diagnoses were identified by International Classification of Disease-10 (ICD-10) codes or stroke databases. We additionally sought to compare the same metrics in the first 5 months of 2021 compared to the corresponding months in 2019 and 2020 (ClinicalTrials.gov Identifier: NCT04934020)., [Results] There were 2,313 CVT admissions across the 1-year pre-pandemic (2019) and pandemic year (2020); no differences in CVT volume or CVT mortality were observed. During the first 5 months of 2021, there was an increase in CVT volumes compared to 2019 (27.5%; 95% confidence interval [CI], 24.2 to 32.0; P, [Conclusions] During the 1st year of the COVID-19 pandemic, CVT hospitalization volume and CVT in-hospital mortality did not change compared to the prior year. COVID-19 diagnosis was associated with higher CVT in-hospital mortality. During the first 5 months of 2021, there was an increase in CVT hospitalization volume and increase in CVT-related mortality, partially attributable to VITT., The study was funded by the Society of Vascular and Interventional Neurology research pilot grant.

Published
2022
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19. Global impact of the COVID-19 pandemic on stroke volumes and cerebrovascular events

Author

Nguyen, Thanh N., Qureshi, Muhammad M., Klein, Piers, Yamagami, Hiroshi, Mikulik, Robert, Czlonkowska, Anna, Abdalkader, Mohamad, Sedova, Petra, Sathya, Anvitha, Lo, Hannah C., Mansour, Ossama Yassin, Iversen, Helle Klingenberg, Truelsen, Thomas Clement, Wienecke, Troels, Sobh, Khalid, Ylikotila, Pauli, Alpay, Kemal, Strbian, Daniel, Bernady, Patricia, Casenave, Philippe, Dan, Maria, Vanguru, Husitha Reddy, Faucheux, Jean-Marc, Gentric, Jean-Christophe, Magro, Elsa, Sabben, Candice, Reiner, Peggy, Rouanet, Francois, Bohmann, Ferdinand O., Boskamp, Stefan, Mbroh, Joshua, Nagel, Simon, Lesaine, Emilie, Nolte, Christian H., Ringleb, Peter A., Rosenkranz, Michael, Poli, Sven, Thomalla, Götz, Karapanayiotides, Theodoros, Koutroulou, Ioanna, Kargiotis, Odysseas, Palaiodimou, Lina, Barrientos Guerra, Jose Dominguo, Tsivgoulis, Georgios, Huded, Vikram, Menon, Bindu, Nagendra, Shashank, Prajapati, Chintan, Sylaja, P.N., Krishna Pramana, Nyoman Angga, Sani, Achmad Firdaus, Ghoreishi, Abdoreza, Farhoudi, Mehdi, Hokmabadi, Elyar Sadeghi, Loochtan, Aaron I., Raya, Tariq Abu, Kalmanovich, Shani Avnery, Ronen, Levite, Sabetay, Sergiu Ionut, Acampa, Maurizio, Adami, Alessandro, Castellan, Lucio, Longoni, Marco, Ornello, Raffaele, Renieri, Leonardo, Demeestere, Jelle, Bigliani, Claudia Rolla, Romoli, Michele, Sacco, Simona, Salmaggi, Andrea, Sangalli, Davide, Zini, Andrea, Doijiri, Ryosuke, Fukuda, Hiroki, Fujinaka, Toshiyuki, Fujita, Kyohei, Uchino, Ken, Imamura, Hirotoshi, Sakai, Nobuyuki, Kanamaru, Takuya, Kimura, Naoto, Kono, Ryuhei, Miyake, Kosuke, Sakaguchi, Manabu, Sakai, Kenichiro, Sonoda, Kazutaka, Todo, Kenichi, Inoa, Violiza, Miyashita, Fumio, Tokuda, Naoki, Matsumaru, Yuji, Matsumoto, Shoji, Ohara, Nobuyuki, Shindo, Seigo, Takenobu, Yohei, Yoshimoto, Takeshi, Toyoda, Kazunori, Uwatoko, Takeshi, Goyal, Nitin, Yagita, Yoshiki, Yamada, Takehiro, Yamamoto, Nobuaki, Yamamoto, Ryoo, Yazawa, Yukako, Sugiura, Yuri, Waweru, Peter Kuria, Baek, Jang-Hyun, Lee, Si Baek, Seo, Kwon-Duk, Charidimou, Andreas, Sohn, Sung-Il, Arsovska, Anita Ante, Chan, Yong Chieh, Wan Zaidi, Wan Asyraf, Jaafar, Ainul Syahrilfazli, Gongora-Rivera, Fernando, Martinez-Marino, Manuel, Infante-Valenzuela, Adrian, Groppa, Stanislav, Leahu, Pavel, Siegler, James E., Coutinho, Jonathan M., Rinkel, Leon A., Dippel, Diederik W.J., van Dam-Nolen, Dianne H.K., Ranta, Annemarei, Wu, Teddy Y., Adebayo, Tajudeen Temitayo, Bello, Abiodun H., Nwazor, Ernest Okwundu, Sunmonu, Taofiki Ajao, Yaghi, Shadi, Wahab, Kolawole Wasiu, Ronning, Ole Morten, Sandset, Else Charlotte, Al Hashmi, Amal M., Ahmad, Saima, Rashid, Umair, Rodriguez-Kadota, Liliana, Vences, Miguel Ángel, Yalung, Patrick Matic, Hao Dy, Jon Stewart, de Sousa, Diana Aguiar, Pineda-Franks, Maria Carissa, Co, Christian Oliver, Brola, Waldemar, Debiec, Aleksander, Dorobek, Malgorzata, Karlinski, Michal Adam, Labuz-Roszak, Beata M., Lasek-Bal, Anetta, Sienkiewicz-Jarosz, Halina, Staszewski, Jacek, Mohammaden, Mahmoud H., Sobolewski, Piotr, Wiacek, Marcin, Zielinska-Turek, Justyna, Araujo, Andre Pinho, Rocha, Mariana, Castro, Pedro, Cruz, Vitor Tedim, Ferreira, Paulo Venancio, Ferreira, Patricia, Nunes, Ana Paiva, Haussen, Diogo C., Fonseca, Luisa, Marto, João Pedro, Melo, Teresa Pinho e, Rodrigues, Miguel, Silva, M. Luis, Dimitriade, Adela, Falup-Pecurariu, Cristian, Hamid, May Adel, Venketasubramanian, Narayanaswamy, Krastev, Georgi, Kristoffersen, Espen Saxhaug, Mako, Miroslav, Ayo-Martin, Oscar, Hernández-Fernández, Francisco, Blasco, Jordi, Rodríguez-Vázquez, Alejandro, Cruz-Culebras, Antonio, Moniche, Francisco, Montaner, Joan, Perez-Sanchez, Soledad, García Sánchez, María Jesús, Lereis, Virginia Pujol, Guillán Rodríguez, Marta, Jood, Katarina, Nordanstig, Annika, Mazya, Michael V., Moreira, Tiago T.P., Bernava, Gianmarco, Beyeler, Morin, Bolognese, Manuel, Carrera, Emmanuel, Dobrocky, Tomas, Scollo, Sergio Daniel, Karwacki, Grzegorz Marek, Keller, Emanuela, Hsieh, Chang Yang, Boonyakarnkul, Surawan, Churojana, Anchalee, Aykac, Ozlem, Ozdemir, Atilla Özcan, Bajrami, Arsida, Senadim, Songul, Hussain, Syed Irteza, Campbell, Bruce C. V., John, Seby, Banerjee, Soma, Kwan, Joseph, Krishnan, Kailash, Lenthall, Robert, Matthews, Ashok, Wong, Ken, Zhang, Liqun, Altschul, Dorothea, Asif, Kaiz S., Ma, Alice, Bahiru, Zeelalem, Below, Kristine, Biller, José, Ruland, Sean, Chaudry, Saqib A., Chen, Michael, Chebl, Alex, Cibulka, Jackie, Cistrunk, Leon, Clark, Judith, Thomas, James Orton, Colasurdo, Marco, Czap, Alexandra, de Havenon, Adam, D'Amato, Salvatore, Dharmadhikari, Sushrut, Grimmett, Kasey B., Dmytriw, Adam A., Etherton, Mark R., Ezepue, Chizoba, Farooqui, Mudassir, Parsons, Mark W., Feske, Steven K., Fink, Lauren, Gasimova, Ulviyya, Guzik, Amy K., Hakemi, Maryam, Hovingh, Majesta, Khan, Muhib, Jillela, Dinesh, Kan, Peter T., Khatri, Rakesh, Singhal, Shaloo, Khawaja, Ayaz M., Khoury, Naim N., Kiley, Nicole L., Kim, Benny S., Kolikonda, Murali K., Kuhn, Anna Luisa, Lara, Stephanie, Linares, Guillermo, Linfante, Italo, Lukovits, Timothy G., Slater, Lee-Anne, Lycan, Sarah, Male, Shailesh S., Maali, Laith, Mancin, John, Masoud, Hesham, Mohamed, Ghada A., Monteiro, Andre, Nahab, Fadi, Nalleballe, Krishna, Ortega-Gutierrez, Santiago, Tomazini Martins, Rodrigo, Puri, Ajit S., Radaideh, Yazan, Rahangdale, Rahul H., Rai, Ansaar, Ramakrishnan, Pankajavalli, Reddy, Aravind B., Rojas-Soto, Diana M., Romero, Jose Rafael, Rost, Natalia S., Rothstein, Aaron, Enzinger, Chris, Omran, Setareh Salehi, Sheth, Sunil A., Siddiqui, Adnan H., Starosciak, Amy K., Tarlov, Nicholas E., Taylor, Robert A., Wang, Michael J., Wolfe, Jared, Wong, Ka-Ho, Le, Huynh Vu, Gattringer, Thomas, Nguyen, Quy Viet, Pham, Thong Nhu, Nguyen, Trung Thanh, Phan, Hoang Thi, Ton, Mai Duy, Fischer, Urs, Michel, Patrik, Strambo, Davide, Martins, Sheila O., Zaidat, Osama O., Rahman, Aminur, Nogueira, Raul G., Bonnet, Thomas, Ligot, Noemie, De Raedt, Sylvie, Lemmens, Robin, Vanacker, Peter, Vandervorst, Fenne, Conforto, Adriana Bastos, Hidalgo, Raquel C.T., de Oliveira Neves, Luciana, Martins, Rodrigo Targa, Mora Cuervo, Daissy Liliana, Rebello, Leticia C., Santiago, Igor Bessa, Lameirinhas da Silva, Isabelle, Sakelarova, Teodora, Kalpachki, Rosen, Alexiev, Filip, Catanese, Luciana, Cora, Elena Adela, Goyal, Mayank, Hill, Michael D., Kelly, Michael E., Khosravani, Houman, Lavoie, Pascale, Peeling, Lissa, Pikula, Aleksandra, Rivera, Rodrigo, Chen, Hui-Sheng, Chen, Yimin, Huo, Xiaochuan, Miao, Zhongrong, Yang, Shuiquan, Bedekovic, Marina Roje, Bralic, Marina, Budincevic, Hrvoje, Corredor-Quintero, Angel Basilio, Lara-Sarabia, Osvaldo E., Cabal, Martin, Tenora, Dusan, Fibrich, Petr, Herzig, Roman, Hlaváčová, Helena, Hrabanovska, Emanuela, Hlinovsky, David, Jurak, Lubomir, Kadlcikova, Jana, Karpowicz, Igor, Klecka, Lukas, Kovar, Martin, Lauer, David, Neumann, Jiri, Palouskova, Hana, Reiser, Martin, Rekova, Petra, Rohan, Vladimir, Skoda, Ondrej, Škorňa, Miroslav, Sobotková, Lenka, Sramek, Martin, Zakova, Lenka, Christensen, Hanne, Drenck, Nicolas, and Repositório da Universidade de Lisboa

Abstract

© 2022 American Academy of Neurology, Background and objectives: Declines in stroke admission, IV thrombolysis (IVT), and mechanical thrombectomy volumes were reported during the first wave of the COVID-19 pandemic. There is a paucity of data on the longer-term effect of the pandemic on stroke volumes over the course of a year and through the second wave of the pandemic. We sought to measure the effect of the COVID-19 pandemic on the volumes of stroke admissions, intracranial hemorrhage (ICH), IVT, and mechanical thrombectomy over a 1-year period at the onset of the pandemic (March 1, 2020, to February 28, 2021) compared with the immediately preceding year (March 1, 2019, to February 29, 2020). Methods: We conducted a longitudinal retrospective study across 6 continents, 56 countries, and 275 stroke centers. We collected volume data for COVID-19 admissions and 4 stroke metrics: ischemic stroke admissions, ICH admissions, IVT treatments, and mechanical thrombectomy procedures. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases. Results: There were 148,895 stroke admissions in the 1 year immediately before compared with 138,453 admissions during the 1-year pandemic, representing a 7% decline (95% CI [95% CI 7.1-6.9]; p < 0.0001). ICH volumes declined from 29,585 to 28,156 (4.8% [5.1-4.6]; p < 0.0001) and IVT volume from 24,584 to 23,077 (6.1% [6.4-5.8]; p < 0.0001). Larger declines were observed at high-volume compared with low-volume centers (all p < 0.0001). There was no significant change in mechanical thrombectomy volumes (0.7% [0.6-0.9]; p = 0.49). Stroke was diagnosed in 1.3% [1.31-1.38] of 406,792 COVID-19 hospitalizations. SARS-CoV-2 infection was present in 2.9% ([2.82-2.97], 5,656/195,539) of all stroke hospitalizations. Discussion: There was a global decline and shift to lower-volume centers of stroke admission volumes, ICH volumes, and IVT volumes during the 1st year of the COVID-19 pandemic compared with the prior year. Mechanical thrombectomy volumes were preserved. These results suggest preservation in the stroke care of higher severity of disease through the first pandemic year.

Published
2023

20. Three-dimensional rotational angiography improves mechanical thrombectomy recanalization rate for acute ischaemic stroke due to middle cerebral artery M2 segment occlusions

Author

Rosi, Andrea, primary, Bernava, Gianmarco, additional, Hofmeister, Jeremy, additional, Nicolò, Madruzzato, additional, Boto, José, additional, Yilmaz, Hasan, additional, Reymond, Philippe, additional, Brina, Olivier, additional, Muster, Michel, additional, Carrera, Emmanuel, additional, Lövblad, Karl-Olof, additional, and Machi, Paolo, additional

Published
2022
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21. In vitro evaluation of how the presence of the stent retriever and microcatheter influences aspiration parameters in thrombectomy according to their position inside the aspiration catheter

Author

Bernava, Gianmarco, primary, Brina, Olivier, additional, Reymond, Philippe, additional, Rosi, Andrea, additional, Hofmeister, Jeremy, additional, Yilmaz, Hasan, additional, Muster, Michel, additional, Kulcsar, Zsolt, additional, Lovblad, Karl-Olof, additional, and Machi, Paolo, additional

Published
2022
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23. In vitro evaluation of how the presence of the stent retriever and microcatheter influences aspiration parameters in thrombectomy according to their position inside the aspiration catheter

Author

Bernava, Gianmarco, Brina, Olivier, Reymond, Philippe, Rosi, Andrea, Hofmeister, Jeremy, Yilmaz, Hasan, Muster, Michel, Kulcsar, Zsolt, Lovblad, Karl-Olof, Machi, Paolo, University of Zurich, and Bernava, Gianmarco

Subjects
2728 Neurology (clinical), 10043 Clinic for Neuroradiology, 2741 Radiology, Nuclear Medicine and Imaging, 610 Medicine & health, 2705 Cardiology and Cardiovascular Medicine
Published
2022
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24. In vitro evaluation of how the presence of the stent retriever and microcatheter influences aspiration parameters in thrombectomy according to their position inside the aspiration catheter

Author

Bernava, Gianmarco; https://orcid.org/0000-0003-2037-5558, Brina, Olivier, Reymond, Philippe, Rosi, Andrea; https://orcid.org/0000-0003-0286-2889, Hofmeister, Jeremy, Yilmaz, Hasan, Muster, Michel, Kulcsar, Zsolt; https://orcid.org/0000-0002-6805-5150, Lovblad, Karl-Olof, Machi, Paolo, Bernava, Gianmarco; https://orcid.org/0000-0003-2037-5558, Brina, Olivier, Reymond, Philippe, Rosi, Andrea; https://orcid.org/0000-0003-0286-2889, Hofmeister, Jeremy, Yilmaz, Hasan, Muster, Michel, Kulcsar, Zsolt; https://orcid.org/0000-0002-6805-5150, Lovblad, Karl-Olof, and Machi, Paolo

Abstract

BACKGROUND Several variations of the combined thrombectomy technique for acute ischemic stroke using a stent retriever and aspiration catheter have been described. The aim of our study was to assess how the presence of the microcatheter and stent retriever affect the basic aspiration parameters, namely, flow rate and aspiration force, depending on their position within the aspiration catheter. METHODS Two experimental set-ups were designed to assess changes in flow rate and aspiration force according to the position of the stent retriever and microcatheter within the aspiration catheter. RESULTS The transition of the stent retriever and microcatheter from the distal to proximal position resulted in a progressive increase in the flow rate, but with no impact on aspiration force. Additionally, the size of the stent retriever had no significant effect on flow rate changes and the reduction in flow rate was related to the microcatheter diameter. Negative pressure generated inside the aspiration catheter impacted on its distal segment located beyond the radiopaque marker, thus leading to its partial collapse. As a consequence, the measured aspiration force was lower than the theoretical aspiration force level for all tested aspiration catheters. CONCLUSIONS In our experimental model, the position of the stent retriever and microcatheter within the aspirator catheter affected the flow rate, but not the aspiration force. Negative pressure generated within the aspiration catheter appeared to determine a partial collapse of the distal segment that resulted in a less effective aspiration force than the theoretical aspiration force level.

Published
2022

25. Multimodality Characterization of the Clot in Acute Stroke

Author

LaGrange, Daniela Dumitriu, primary, Wanke, Isabel, additional, Machi, Paolo, additional, Bernava, Gianmarco, additional, Vargas, Maria, additional, Botta, Daniele, additional, Berberat, Jatta, additional, Muster, Michel, additional, Platon, Alexandra, additional, Poletti, Pierre-Alexandre, additional, and Lövblad, Karl-Olof, additional

Published
2021
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27. Global Impact of COVID-19 on Stroke Care and IV Thrombolysis

Author

Nogueira, Raul, Qureshi, Muhammad, Abdalkader, Mohamad, Martins, Sheila Ouriques, Yamagami, Hiroshi, Qiu, Zhongming, Mansour, Ossama Yassin, Sathya, Anvitha, Czlonkowska, Anna, Tsivgoulis, Georgios, Aguiar de Sousa, Diana, Demeestere, Jelle, Mikulik, Robert, Vanacker, Peter, Siegler, James, Kõrv, Janika, Biller, Jose, Liang, Conrad, Sangha, Navdeep, Zha, Alicia, Czap, Alexandra, Holmstedt, Christine Anne, Turan, Tanya, Ntaios, George, Malhotra, Konark, Tayal, Ashis, Loochtan, Aaron, Ranta, Annamarei, Mistry, Eva, Alexandrov, Anne, Huang, David, Yaghi, Shadi, Raz, Eytan, Sheth, Sunil, Mohammaden, Mahmoud, Frankel, Michael, Bila Lamou, Eric Guemekane, Aref, Hany, Elbassiouny, Ahmed, Hassan, Farouk, Menecie, Tarek, Mustafa, Wessam, Shokri, Hossam, Roushdy, Tamer, Sarfo, Fred, Alabi, Tolulope Oyetunde, Arabambi, Babawale, Nwazor, Ernest, Sunmonu, Taofiki Ajao, Wahab, Kolawole, Yaria, Joseph, Mohammed, Haytham Hussein, Adebayo, Philip, Riahi, Anis, Sassi, Samia Ben, Gwaunza, Lenon, Ngwende, Gift Wilson, Sahakyan, David, Rahman, Aminur, Ai, Zhibing, Bai, Fanghui, Duan, Zhenhui, Hao, Yonggang, Huang, Wenguo, Li, Guangwen, Li, Wei, Liu, Ganzhe, Luo, Jun, Shang, Xianjin, Sui, Yi, Tian, Ling, Wen, Hongbin, Wu, Bo, Yan, Yuying, Yuan, Zhengzhou, Zhang, Hao, Zhang, Jun, Zhao, Wenlong, Zi, Wenjie, Leung, Thomas, Chugh, Chandril, Huded, Vikram, Menon, Bindu, Pandian, Jeyaraj Durai, Sylaja, Pn, Usman, Fritz Sumantri, Farhoudi, Mehdi, Hokmabadi, Elyar Sadeghi, Horev, Anat, Reznik, Anna, Sivan Hoffmann, Rotem, Ohara, Nobuyuki, Sakai, Nobuyuki, Watanabe, Daisuke, Yamamoto, Ryoo, Doijiri, Ryosuke, Tokuda, Naoki, Yamada, Takehiro, Terasaki, Tadashi, Yazawa, Yukako, Uwatoko, Takeshi, Dembo, Tomohisa, Shimizu, Hisao, Sugiura, Yuri, Miyashita, Fumio, Fukuda, Hiroki, Miyake, Kosuke, Shimbo, Junsuke, Sugimura, Yusuke, Yagita, Yoshiki, Takenobu, Yohei, Matsumaru, Yuji, Yamada, Satoshi, Kono, Ryuhei, Kanamaru, Takuya, Yamazaki, Hidekazu, Sakaguchi, Manabu, Todo, Kenichi, Yamamoto, Nobuaki, Sonoda, Kazutaka, Yoshida, Tomoko, Hashimoto, Hiroyuki, Nakahara, Ichiro, Kondybayeva, Aida, Faizullina, Kamila, Kamenova, Saltanat, Zhanuzakov, Murat, Baek, Jang-Hyun, Hwang, Yangha, Lee, Jin Soo, Lee, Si Baek, Moon, Jusun, Park, Hyungjong, Seo, Jung Hwa, Seo, Kwon-Duk, Sohn, Sung Il, Young, Chang Jun, Ahdab, Rechdi, Wan Zaidi, Wan Asyraf, Aziz, Zariah Abdul, Basri, Hamidon Bin, Chung, Law Wan, Ibrahim, Aznita Binti, Ibrahim, Khairul Azmi, Looi, Irene, Tan, Wee Yong, Yahya, Nafisah Wan, Groppa, Stanislav, Leahu, Pavel, Al Hashmi, Amal, Imam, Yahia Zakaria, Akhtar, Naveed, Pineda-Franks, Maria Carissa, Co, Christian Oliver, Kandyba, Dmitriy, Alhazzani, Adel, Al-Jehani, Hosam, Tham, Carol Huilian, Mamauag, Marlie Jane, Venketasubramanian, Narayanaswamy, Chen, Chih-Hao, Tang, Sung-Chun, Churojana, Anchalee, Akil, Esref, Aykaç, Özlem, Ozdemir, Atilla Ozcan, Giray, Semih, Hussain, Syed Irteza, John, Seby, Le Vu, Huynh, Tran, Anh Duc, Nguyen, Huy Hoang, Nhu Pham, Thong, Nguyen, Thang Huy, Nguyen, Trung Quoc, Gattringer, Thomas, Enzinger, Christian, Killer-Oberpfalzer, Monika, Bellante, Flavio, de Blauwe, Sofie, Vanhooren, Geert, de Raedt, Sylvie, Dusart, Anne, Lemmens, Robin, Ligot, Noemie, Pierre Rutgers, Matthieu, Yperzeele, Laetitia, Alexiev, Filip, Sakelarova, Teodora, Bedeković, Marina Roje, Budincevic, Hrvoje, Cindric, Igor, Hucika, Zlatko, Ozretic, David, Saric, Majda Seferovic, Pfeifer, František, Karpowic, Igor, Cernik, David, Sramek, Martin, Skoda, Miroslav, Hlavacova, Helena, Klecka, Lukas, Koutny, Martin, Vaclavik, Daniel, Skoda, Ondrej, Fiksa, Jan, Hanelova, Katerina, Nevsimalova, Miroslava, Rezek, Robert, Prochazka, Petr, Krejstova, Gabriela, Neumann, Jiri, Vachova, Marta, Brzezanski, Henryk, Hlinovsky, David, Tenora, Dusan, Jura, Rene, Jurák, Lubomír, Novak, Jan, Novak, Ales, Topinka, Zdenek, Fibrich, Petr, Sobolova, Helena, Volny, Ondrej, Krarup Christensen, Hanne, Drenck, Nicolas, Klingenberg Iversen, Helle, Simonsen, Claus, Truelsen, Thomas Clement, Wienecke, Troels, Vibo, Riina, Gross-Paju, Katrin, Toomsoo, Toomas, Antsov, Katrin, Caparros, Francois, Cordonnier, Charlotte, Dan, Maria, Faucheux, Jean-Marc, Mechtouff, Laura, Eker, Omer, Lesaine, Emilie, Ondze, Basile, Peres, Roxane, Pico, Fernando, Piotin, Michel, Pop, Raoul, Rouanet, Francois, Gubeladze, Tatuli, Khinikadze, Mirza, Lobjanidze, Nino, Tsiskaridze, Alexander, Nagel, Simon, Ringleb, Peter Arthur, Rosenkranz, Michael, Schmidt, Holger, Sedghi, Annahita, Siepmann, Timo, Szabo, Kristina, Thomalla, Götz, Palaiodimou, Lina, Sagris, Dimitrios, Kargiotis, Odysseas, Klivenyi, Peter, Szapary, Laszlo, Tarkanyi, Gabor, Adami, Alessandro, Bandini, Fabio, Calabresi, Paolo, Frisullo, Giovanni, Renieri, Leonardo, Sangalli, Davide, Pirson, Anne, Uyttenboogaart, Maarten, van den Wijngaard, Ido, Kristoffersen, Espen Saxhaug, Brola, Waldemar, Fudala, Małgorzata, Horoch-Lyszczarek, Ewa, Karlinski, Michal, Kazmierski, Radoslaw, Kram, Pawel, Rogoziewicz, Marcin, Kaczorowski, Rafal, Luchowski, Piotr, Sienkiewicz-Jarosz, Halina, Sobolewski, Piotr, Fryze, Waldemar, Wisniewska, Anna, Wiszniewska, Malgorzata, Ferreira, Patricia, Ferreira, Paulo, Fonseca, Luisa, Marto, João Pedro, Pinho E Melo, Teresa, Nunes, Ana Paiva, Rodrigues, Miguel, Tedim Cruz, Vítor, Falup-Pecurariu, Cristian, Krastev, Georgi, Mako, Miroslav, de Leciñana, María Alonso, Arenillas, Juan, Ayo-Martin, Oscar, Cruz Culebras, Antonio, Tejedor, Exuperio Diez, Montaner, Joan, Pérez-Sánchez, Soledad, Tola Arribas, Miguel Angel, Rodriguez Vasquez, Alejandro, Mayza, Michael, Bernava, Gianmarco, Brehm, Alex, Machi, Paolo, Fischer, Urs, Gralla, Jan, Michel, Patrik, Psychogios, Marios-Nikos, Strambo, Davide, Banerjee, Soma, Krishnan, Kailash, Kwan, Joseph, Butt, Asif, Catanese, Luciana, Demchuk, Andrew, Field, Thalia, Haynes, Jennifer, Hill, Michael, Khosravani, Houman, Mackey, Ariane, Pikula, Aleksandra, Saposnik, Gustavo, Scott, Courtney Anne, Shoamanesh, Ashkan, Shuaib, Ashfaq, Yip, Samuel, Barboza, Miguel, Barrientos, Jose Domingo, Portillo Rivera, Ligia Ibeth, Gongora-Rivera, Fernando, Novarro-Escudero, Nelson, Blanco, Anmylene, Abraham, Michael, Alsbrook, Diana, Altschul, Dorothea, Alvarado-Ortiz, Anthony, Bach, Ivo, Badruddin, Aamir, Barazangi, Nobl, Brereton, Charmaine, Castonguay, Alicia, Chaturvedi, Seemant, Chaudry, Saqib, Choe, Hana, Choi, Jae, Dharmadhikari, Sushrut, Desai, Kinjal, Devlin, Thomas, Doss, Vinodh, Edgell, Randall, Etherton, Mark, Farooqui, Mudassir, Frei, Don, Gandhi, Dheeraj, Grigoryan, Mikayel, Gupta, Rishi, Hassan, Ameer, Helenius, Johanna, Kaliaev, Artem, Kaushal, Ritesh, Khandelwal, Priyank, Khawaja, Ayaz, Khoury, Naim, Kim, Benny, Kleindorfer, Dawn, Koyfman, Feliks, Lee, Vivien, Leung, Lester, Linares, Guillermo, Linfante, Italo, Lutsep, Helmi, Macdougall, Lisa, Male, Shailesh, Malik, Amer, Masoud, Hesham, Mcdermott, Molly, Mehta, Brijesh, Min, Jiangyong, Mittal, Manoj, Morris, Jane, Multani, Sumeet, Nahab, Fadi, Nalleballe, Krishna, Nguyen, Claude, Novakovic-White, Roberta, Ortega-Gutierrez, Santiago, Rahangdale, Rahul, Ramakrishnan, Pankajavalli, Romero, Jose Rafael, Rost, Natalia, Rothstein, Aaron, Ruland, Sean, Shah, Ruchir, Sharma, Malveeka, Silver, Brian, Simmons, Marc, Singh, Abhishek, Starosciak, Amy, Strasser, Sheryl, Szeder, Viktor, Teleb, Mohamed, Tsai, Jenny, Voetsch, Barbara, Balaguera, Oscar, Pujol Lereis, Virginia, Luraschi, Adriana, Almeida, Marcele Schettini, Cardoso, Fabricio Buchdid, Conforto, Adriana, de Deus Silva, Leonardo, Varrone Giacomini, Luidia, Oliveira Lima, Fabricio, Longo, Alexandre, Magalhães, Pedro, Martins, Rodrigo Targa, Mont'Alverne, Francisco, Mora Cuervo, Daissy Liliana, Costa Rebello, Leticia, Valler, Lenise, Zetola, Viviane Flumignan, Lavados, Pablo, Navia, Victor, Olavarría, Verónica, Almeida Toro, Juan Manuel, Amaya, Pablo Felipe Ricardo, Bayona, Hernan, Corredor, Angel, Rivera Ordonez, Carlos Eduardo, Mantilla Barbosa, Diana Katherine, Lara, Osvaldo, Patiño, Mauricio, Diaz Escobar, Luis Fernando, Dejesus Melgarejo Fariña, Donoband Edson, Cardozo Villamayor, Analia, Zelaya Zarza, Adolfo Javier, Barrientos Iman, Danny Moises, Rodriguez Kadota, Liliana, Campbell, Bruce, Hankey, Graeme, Hair, Casey, Kleinig, Timothy, Ma, Alice, Tomazini Martins, Rodrigo, Sahathevan, Ramesh, Thijs, Vincent, Salazar, Daniel, Yuan-Hao Wu, Teddy, Haussen, Diogo, Liebeskind, David, Yavagal, Dileep, Jovin, Tudor, Zaidat, Osama, Nguyen, Thanh, Magalhães, Pedro S.C., Emory University School of Medicine, Emory University [Atlanta, GA], Boston University School of Medicine (BUSM), Boston University [Boston] (BU), Lille Neurosciences & Cognition - U 1172 (LilNCog), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Max Super Speciality Hospital -Saket [New Delhi, Inde] (Max Saket), Dupuis, Christine, Lille Neurosciences & Cognition - U 1172 (LilNCog (ex-JPARC)), and Repositório da Universidade de Lisboa

Subjects
medicine.medical_specialty, MESH: Pandemics, HSJ NEU, Cross-sectional study, medicine.medical_treatment, [SDV]Life Sciences [q-bio], SVIN COVID-19 Global Stroke Registry, MESH: Hospitalization, 030204 cardiovascular system & hematology, Article, MESH: Stroke, COVID-19, cross-sectional studies, hospitalization, humans, pandemics, retrospective studies, SARS-CoV-2, stroke, 03 medical and health sciences, 0302 clinical medicine, MESH: Cross-Sectional Studies, Pandemic, Medicine, Humans, MESH: COVID-19, Thrombolytic Therapy, MESH: SARS-CoV-2, Stroke, Pandemics, Retrospective Studies, MESH: Thrombolytic Therapy, Rehabilitation, MESH: Humans, business.industry, Retrospective cohort study, MESH: Retrospective Studies, medicine.disease, Thrombolysis, Confidence interval, 3. Good health, Hospitalization, [SDV] Life Sciences [q-bio], Clinical research, Cross-Sectional Studies, Emergency medicine, Observational study, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract

© 2021 American Academy of Neurology, Objective: To measure the global impact of COVID-19 pandemic on volumes of IV thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with 2 control 4-month periods. Methods: We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes or classifications in stroke databases. Results: There were 91,373 stroke admissions in the 4 months immediately before compared to 80,894 admissions during the pandemic months, representing an 11.5% (95% confidence interval [CI] -11.7 to -11.3, p < 0.0001) decline. There were 13,334 IVT therapies in the 4 months preceding compared to 11,570 procedures during the pandemic, representing a 13.2% (95% CI -13.8 to -12.7, p < 0.0001) drop. Interfacility IVT transfers decreased from 1,337 to 1,178, or an 11.9% decrease (95% CI -13.7 to -10.3, p = 0.001). Recovery of stroke hospitalization volume (9.5%, 95% CI 9.2-9.8, p < 0.0001) was noted over the 2 later (May, June) vs the 2 earlier (March, April) pandemic months. There was a 1.48% stroke rate across 119,967 COVID-19 hospitalizations. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was noted in 3.3% (1,722/52,026) of all stroke admissions. Conclusions: The COVID-19 pandemic was associated with a global decline in the volume of stroke hospitalizations, IVT, and interfacility IVT transfers. Primary stroke centers and centers with higher COVID-19 inpatient volumes experienced steeper declines. Recovery of stroke hospitalization was noted in the later pandemic months.

Published
2021
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28. Global impact of COVID-19 on stroke care

Author

Nogueira, Raul G., Abdalkader, Mohamad, Qureshi, Muhammed M., Frankel, Michael R., Mansour, Ossama Yassin, Yamagami, Hiroshi, Qiu, Zhongming, Farhoudi, Mehdi, Siegler, James E, Yaghi, Shadi, Raz, Eytan, Sakai, Nobuyuki, Ohara, Nobuyuki, Piotin, Michel, Mechtouff, Laura, Eker, Omer, Chalumeau, Vanessa, Kleinig, Timothy J., Pop, Raoul, Liu, Jianmin, Winters, Hugh S., Shang, Xianjin, Rodriguez Vasquez, Alejandro, Blasco, Jordi, Arenillas, Juan F, Martinez-Galdamez, Mario, Brehm, Alex, Psychogios, Marios-Nikos, Lylyk, Pedro, Haussen, Diogo C., Al-Bayati, Alhamza R., Mohammaden, Mahmoud H., Fonseca, Luísa, Luís Silva, M., Montalverne, Francisco, Renieri, Leonardo, Mangiafico, Salvatore, Fischer, Urs, Gralla, Jan, Frei, Donald, Chugh, Chandril, Mehta, Brijesh P., Nagel, Simon, Mohlenbruch, Markus, Ortega-Gutierrez, Santiago, Farooqui, Mudassir, Hassan, Ameer E, Taylor, Allan, Lapergue, Bertrand, Consoli, Arturo, Campbell, Bruce C.V., Sharma, Malveeka, Walker, Melanie, Van Horn, Noel, Fiehler, Jens, Nguyen, Huy Thang, Nguyen, Quoc T., Watanabe, Daisuke, Zhang, Hao, Le, Huynh V., Nguyen, Viet Q., Shah, Ruchir, Devlin, Thomas, Khandelwal, Priyank, Linfante, Italo, Izzath, Wazim, Lavados, Pablo M., Olavarría, Veronica V., Sampaio Silva, Gisele, de Carvalho Sousa, Anna Verena, Kirmani, Jawad, Bendszus, Martin, Amano, Tatsuo, Yamamoto, Ryoo, Doijiri, Ryosuke, Tokuda, Naoki, Yamada, Takehiro, Terasaki, Tadashi, Yazawa, Yukako, Morris, Jane G., Griffin, Emma, Thornton, John, Lavoie, Pascale, Matouk, Charles, Hill, M. D, Demchuk, Andrew M., Killer-Oberpfalzer, Monika, Nahab, Fadi, Altschul, Dorothea, Ramos-Pachón, Anna, Pérez de la Ossa, Natalia, Kikano, Raghid, Boisseau, William, Walker, Gregory, Cordina, Steve M., Puri, Ajit, Luisa Kuhn, Anna, Gandhi, Dheeraj, Ramakrishnan, Pankajavalli, Novakovic-White, Roberta, Chebl, Alex, Kargiotis, Odysseas, Czap, Alexandra L, Zha, Alicia M, Masoud, Hesham E., Lopez, Carlos, Ozretic, David, Al-Mufti, Fawaz, Zie, Wenjie, Duan, Zhenhui, Yuan, Zhengzhou, Huang, Wenguo, Hao, Yonggang, Luo, Jun, Kalousek, Vladimir, Bourcier, Romain, Guile, Romain, Hetts, Steven, Al-Jehani, Hosam M., AlHazzani, Adel, Sadeghi-Hokmabadi, Elyar, Teleb, Mohamed, Payne, Jeremy, Lee, Jin Soo, Hong, Ji Man, Sohn, Sung-Il, Hwang, Yang-Ha, Shin, Dong Hoon, Roh, Hong Gee, Edgell, Randy, Khatri, Rakesh, Smith, Ainsley, Malik, Amer, Liebeskind, David, Herial, Nabeel, Jabbour, Pascal, Magalhaes, Pedro, Ozdemir, Atilla Ozcan, Aykac, Ozlem, Uwatoko, Takeshi, Dembo, Tomohisa, Shimizu, Hisao, Sugiura, Yuri, Miyashita, Fumio, Fukuda, Hiroki, Miyake, Kosuke, Shimbo, Junsuke, Sugimura, Yusuke, Beer-Furlan, Andre, Joshi, Krishna, Catanese, Luciana, Abud, Daniel Giansante, Neto, Octavio Giansante, Mehrpour, Masoud, Al Hashmi, Amal, Saqqur, Mahar, Mostafa, Abdulrahman, Fifi, Johanna T., Hussain, Syed, John, Seby, Gupta, Rishi, Sivan-Hoffmann, Rotem, Reznik, Anna, Sani, Achmad Fidaus, Geyik, Serdar, Akıl, Eşref, Churojana, Anchalee, Ghoreishi, Abdoreza, Saadatnia, Mohammad, Sharifipour, Ehsan, Ma, Alice, Faulder, Ken, Wu, Teddy, Leung, Lester, Malek, Adel, Voetsch, Barbara, Wakhloo, Ajay, Rivera, Rodrigo, Barrientos Iman, Danny Moises, Pikula, Aleksandra, Lioutas, Vasileios-Arsenios, Thomalla, Gotz, Birnbaum, Lee, Machi, Paolo, Bernava, Gianmarco, McDermott, Mollie, Kleindorfer, Dawn, Wong, Ken, Patterson, Mary S., Fiorot, Jose Antonio, Huded, Vikram, Mack, William, Tenser, Matthew, Eskey, Clifford, Multani, Sumeet, Kelly, Michael, Janardhan, Vallabh, Cornett, Oriana, Singh, Varsha, Murayama, Yuichi, Mokin, Maxim, Yang, Pengfei, Zhang, Xiaoxi, Yin, Congguo, Han, Hongxing, Peng, Ya, Chen, Wenhuo, Crosa, Roberto, Frudit, Michel E., Pandian, Jeyaraj D., Kulkarni, Anirudh, Yagita, Yoshiki, Takenobu, Yohei, Matsumaru, Yuji, Yamada, Satoshi, Kono, Ryuhei, Kanamaru, Takuya, Yamazaki, Hidekazu, Sakaguchi, Manabu, Todo, Kenichi, Yamamoto, Nobuaki, Sonoda, Kazutaka, Yoshida, Tomoko, Hashimoto, Hiroyuki, Nakahara, Ichiro, Cora, Elena, Volders, David, Ducroux, Celina, Shoamanesh, Ashkan, Ospel, Johanna, Kaliaev, Artem, Ahmed, Saima, Rashid, Umair, Rebello, Leticia C., Pereira, Vitor Mendes, Fahed, Robert, Chen, Michael, Sheth, Sunil A., Palaiodimou, Lina, Tsivgoulis, Georgios, Chandra, Ronil, Koyfman, Feliks, Leung, Thomas, Khosravani, Houman, Dharmadhikari, Sushrut, Frisullo, Giovanni, Calabresi, Paolo, Tsiskaridze, Alexander, Lobjanidze, Nino, Grigoryan, Mikayel, Czlonkowska, Anna, de Sousa, Diana A., Demeestere, Jelle, Liang, Conrad, Sangha, Navdeep, Lutsep, Helmi L., Ayo-Martín, Óscar, Cruz-Culebras, Antonio, Tran, Anh D., Young, Chang Y., Cordonnier, Charlotte, Caparros, Francois, De Lecinana, Maria Alonso, Fuentes, Blanca, Yavagal, Dileep, Jovin, Tudor, Spelle, Laurent, Moret, Jacques, Khatri, Pooja, Zaidat, Osama, Raymond, Jean, Martins, Sheila, Nguyen, Thanh N, Universitat Autònoma de Barcelona, and UAM. Departamento de Medicina

Subjects
Gerontology, 2019-20 coronavirus outbreak, medicine.medical_specialty, acute ischemic stroke, Hospitals, Low-Volume, Time Factors, Coronavirus disease 2019 (COVID-19), Medicina, Clinical Neurology, Stroke care, stroke care, Global Health, mechanical thrombectomy, Pandemic, Epidemiology, Health care, Global health, Medicine, Humans, Registries, Stroke, Retrospective Studies, Thrombectomy, Science & Technology, business.industry, Research, COVID-19, medicine.disease, Hospitalization, Cross-Sectional Studies, Peripheral Vascular Disease, Neurology, Cardiovascular System & Cardiology, epidemiology, Neurosciences & Neurology, business, Life Sciences & Biomedicine, Intracranial Hemorrhages, Hospitals, High-Volume, intracranial hemorrhage
Abstract

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAM, Background: The COVID-19 pandemic led to profound changes in the organization of health care systems worldwide. Aims: We sought to measure the global impact of the COVID-19 pandemic on the volumes for mechanical thrombectomy, stroke, and intracranial hemorrhage hospitalizations over a three-month period at the height of the pandemic (1 March–31 May 2020) compared with two control three-month periods (immediately preceding and one year prior). Methods: Retrospective, observational, international study, across 6 continents, 40 countries, and 187 comprehensive stroke centers. The diagnoses were identified by their ICD-10 codes and/or classifications in stroke databases at participating centers. Results: The hospitalization volumes for any stroke, intracranial hemorrhage, and mechanical thrombectomy were 26,699, 4002, and 5191 in the three months immediately before versus 21,576, 3540, and 4533 during the first three pandemic months, representing declines of 19.2% (95%CI, −19.7 to −18.7), 11.5% (95%CI, −12.6 to −10.6), and 12.7% (95%CI, −13.6 to −11.8), respectively. The decreases were noted across centers with high, mid, and low COVID-19 hospitalization burden, and also across high, mid, and low volume stroke/mechanical thrombectomy centers. High-volume COVID-19 centers (−20.5%) had greater declines in mechanical thrombectomy volumes than mid- (−10.1%) and low-volume (−8.7%) centers (p < 0.0001). There was a 1.5% stroke rate across 54,366 COVID-19 hospitalizations. SARS-CoV-2 infection was noted in 3.9% (784/20,250) of all stroke admissions. Conclusion: The COVID-19 pandemic was associated with a global decline in the volume of overall stroke hospitalizations, mechanical thrombectomy procedures, and intracranial hemorrhage admission volumes. Despite geographic variations, these volume reductions were observed regardless of COVID-19 hospitalization burden and pre-pandemic stroke/mechanical thrombectomy volumes

Published
2021

29. Global Impact of COVID-19 on Stroke Care and Intravenous Thrombolysis

Author

Nogueira, Raul G, Qureshi, Muhammed M, Abdalkader, Mohamad, Martins, Sheila Ouriques, Yamagami, Hiroshi, Qiu, Zhongming, Mansour, Ossama Yassin, Sathya, Anvitha, Czlonkowska, Anna, Tsivgoulis, Georgios, Aguiar de Sousa, Diana, Demeestere, Jelle, Mikulik, Robert, Vanacker, Peter, Siegler, James E, Kõrv, Janika, Biller, Jose, Liang, Conrad W, Sangha, Navdeep S, Zha, Alicia M, Czap, Alexandra L, Holmstedt, Christine Anne, Turan, Tanya N, Ntaios, George, Malhotra, Konark, Tayal, Ashis, Loochtan, Aaron, Ranta, Annamarei, Mistry, Eva A, Alexandrov, Anne W, Huang, David Y, Yaghi, Shadi, Raz, Eytan, Sheth, Sunil A, Mohammaden, Mahmoud H, Frankel, Michael, Bila Lamou, Eric Guemekane, Aref, Hany M, Elbassiouny, Ahmed, Hassan, Farouk, Menecie, Tarek, Mustafa, Wessam, Shokri, Hossam M, Roushdy, Tamer, Sarfo, Fred S, Alabi, Tolulope Oyetunde, Arabambi, Babawale, Nwazor, Ernest O, Sunmonu, Taofiki Ajao, Wahab, Kolawole, Yaria, Joseph, Mohammed, Haytham Hussein, Adebayo, Philip B, Riahi, Anis D, Ben Sassi, Samia, Gwaunza, Lenon, Ngwende, Gift Wilson, Sahakyan, David, Rahman, Aminur, Ai, Zhibing, Bai, Fanghui, Duan, Zhenhui, Hao, Yonggang, Huang, Wenguo, Li, Guangwen, Li, Wei, Liu, Ganzhe, Luo, Jun, Shang, Xianjin, Sui, Yi, Tian, Ling, Wen, Hongbin, Wu, Bo, Yan, Yuying, Yuan, Zhengzhou, Zhang, Hao, Zhang, Jun, Zhao, Wenlong, Zi, Wenjie, Leung, Thomas W, Chugh, Chandril, Huded, Vikram, Menon, Bindu, Pandian, Jeyaraj Durai, Sylaja, P N, Usman, Fritz Sumantri, Farhoudi, Mehdi, Hokmabadi, Elyar Sadeghi, Horev, Anat, Reznik, Anna, Hoffmann, Rotem Sivan, Ohara, Nobuyuki, Sakai, Nobuyuki, Watanabe, Daisuke, Yamamoto, Ryoo, Doijiri, Ryosuke, Tokuda, Naoki, Yamada, Takehiro, Terasaki, Tadashi, Yazawa, Yukako, Uwatoko, Takeshi, Dembo, Tomohisa, Shimizu, Hisao, Sugiura, Yuri, Miyashita, Fumio, Fukuda, Hiroki, Miyake, Kosuke, Shimbo, Junsuke, Sugimura, Yusuke, Yagita, Yoshiki, Takenobu, Yohei, Matsumaru, Yuji, Yamada, Satoshi, Kono, Ryuhei, Kanamaru, Takuya, Yamazaki, Hidekazu, Sakaguchi, Manabu, Todo, Kenichi, Yamamoto, Nobuaki, Sonoda, Kazutaka, Yoshida, Tomoko, Hashimoto, Hiroyuki, Nakahara, Ichiro, Kondybayeva, Aida, Faizullina, Kamila, Kamenova, Saltanat, Zhanuzakov, Murat, Baek, Jang-Hyun, Hwang, Yangha, Lee, Jin Soo, Lee, Si Baek, Moon, Jusun, Park, Hyungjong, Seo, Jung Hwa, Seo, Kwon-Duk, Sohn, Sung Il, Young, Chang Jun, Ahdab, Rechdi, Wan Zaidi, Wan Asyraf, Aziz, Zariah Abdul, Basri, Hamidon Bin, Chung, Law Wan, Ibrahim, Aznita Binti, Ibrahim, Khairul Azmi, Looi, Irene, Tan, Wee Yong, Yahya, Nafisah Wan, Groppa, Stanislav, Leahu, Pavel, Al Hashmi, Amal M, Imam, Yahia Zakaria, Akhtar, Naveed, Pineda-Franks, Maria Carissa, Co, Christian Oliver, Kandyba, Dmitriy, Alhazzani, Adel, Al-Jehani, Hosam, Tham, Carol Huilian, Mamauag, Marlie Jane, Venketasubramanian, Narayanaswamy, Chen, Chih-Hao, Tang, Sung-Chun, Churojana, Anchalee, Akil, Esref, Aykaç, Ozlem, Ozdemir, Atilla Ozcan, Giray, Semih, Hussain, Syed Irteza, John, Seby, Le Vu, Huynh, Tran, Anh Duc, Nguyen, Huy Hoang, Pham, Thong Nhu, Nguyen, Thang Huy, Nguyen, Trung Quoc, Gattringer, Thomas, Enzinger, Christian, Killer-Oberpfalzer, Monika, Bellante, Flavio, De Blauwe, Sofie, Vanhooren, Geert, De Raedt, Sylvie, Dusart, Anne, Lemmens, Robin, Ligot, Noemie, Rutgers, Matthieu Pierre, Yperzeele, Laetitia, Alexiev, Filip, Sakelarova, Teodora, Bedeković, Marina Roje, Budincevic, Hrvoje, Cindrić, Igor, Hucika, Zlatko, Ozretic, David, Saric, Majda Seferovic, Pfeifer, Frantiek, Karpowic, Igor, Cernik, David, Sramek, Martin, Skoda, Miroslav, Hlavacova, Helena, Klecka, Lukas, Koutny, Martin, Vaclavik, Daniel, Skoda, Ondrej, Fiksa, Jan, Hanelova, Katerina, Nevsimalova, Miroslava, Rezek, Robert, Prochazka, Petr, Krejstova, Gabriela, Neumann, Jiri, Vachova, Marta, Brzezanski, Henryk, Hlinovsky, David, Tenora, Dusan, Jura, Rene, Jurák, Lubomír, Novak, Jan, Novak, Ales, Topinka, Zdenek, Fibrich, Petr, Sobolova, Helena, Volny, Ondrej, Christensen, Hanne Krarup, Drenck, Nicolas, Iversen, Helle Klingenberg, Simonsen, Claus Z, Truelsen, Thomas Clement, Wienecke, Troels, Vibo, Riina, Gross-Paju, Katrin, Toomsoo, Toomas, Antsov, Katrin, Caparros, Francois, Cordonnier, Charlotte, Dan, Maria, Faucheux, Jean-Marc, Mechtouff, Laura, Eker, Omer, Lesaine, Emilie, Ondze, Basile, Peres, Roxane, Pico, Fernando, Piotin, Michel, Pop, Raoul, Rouanet, Francois, Gubeladze, Tatuli, Khinikadze, Mirza, Lobjanidze, Nino, Tsikaridze, Alexander, Nagel, Simon, Ringleb, Peter Arthur, Rosenkranz, Michael, Schmidt, Holger, Sedghi, Annahita, Siepmann, Timo, Szabo, Kristina, Thomalla, Götz, Palaiodimou, Lina, Sagris, Dimitrios, Kargiotis, Odysseas, Klivenyi, Peter, Szapary, Laszlo, Tarkanyi, Gabor, Adami, Alessandro, Bandini, Fabio, Calabresi, Paolo, Frisullo, Giovanni, Renieri, Leonardo, Sangalli, Davide, Pirson, Anne V, Uyttenboogaart, Maarten, van den Wijngaard, Ido, Kristoffersen, Espen Saxhaug, Brola, Waldemar, Fudala, Małgorzata, Horoch-Lyszczarek, Ewa, Karlinski, Michal, Kazmierski, Radoslaw, Kram, Pawel, Rogoziewicz, Marcin, Kaczorowski, Rafal, Luchowski, Piotr, Sienkiewicz-Jarosz, Halina, Sobolewski, Piotr, Fryze, Waldemar, Wisniewska, Anna, Wiszniewska, Malgorzata, Ferreira, Patricia, Ferreira, Paulo, Fonseca, Luisa, Marto, João Pedro, Pinho E Melo, Teresa, Nunes, Ana Paiva, Rodrigues, Miguel, Cruz, Vítor Tedim, Falup-Pecurariu, Cristian, Krastev, Georgi, Mako, Miroslav, Alonso de Leciñana, María, Arenillas, Juan F, Ayo-Martin, Oscar, Culebras, Antonio Cruz, Tejedor, Exuperio Diez, Montaner, Joan, Pérez-Sánchez, Soledad, Tola Arribas, Miguel Angel, Vasquez, Alejandro Rodriguez, Mazya, Michael, Bernava, Gianmarco, Brehm, Alex, Machi, Paolo, Fischer, Urs, Gralla, Jan, Michel, Patrik L, Psychogios, Marios-Nikos, Strambo, Davide, Banerjee, Soma, Krishnan, Kailash, Kwan, Joseph, Butt, Asif, Catanese, Luciana, Demchuk, Andrew, Field, Thalia, Haynes, Jennifer, Hill, Michael D, Khosravani, Houman, Mackey, Ariane, Pikula, Aleksandra, Saposnik, Gustavo, Scott, Courtney Anne, Shoamanesh, Ashkan, Shuaib, Ashfaq, Yip, Samuel, Barboza, Miguel A, Barrientos, Jose Domingo, Portillo Rivera, Ligia Ibeth, Gongora-Rivera, Fernando, Novarro-Escudero, Nelson, Blanco, Anmylene, Abraham, Michael, Alsbrook, Diana, Altschul, Dorothea, Alvarado-Ortiz, Anthony J, Bach, Ivo, Badruddin, Aamir, Barazangi, Nobl, Brereton, Charmaine, Castonguay, Alicia, Chaturvedi, Seemant, Chaudhry, Saqib A, Choe, Hana, Choi, Jae H, Dharmadhikari, Sushrut, Desai, Kinjal, Devlin, Thomas G, Doss, Vinodh T, Edgell, Randall, Etherton, Mark, Farooqui, Mudassir, Frei, Don, Gandhi, Dheeraj, Grigoryan, Mikayel, Gupta, Rishi, Hassan, Ameer E, Helenius, Johanna, Kaliaev, Artem, Kaushal, Ritesh, Khandelwal, Priyank, Khawaja, Ayaz M, Khoury, Naim N, Kim, Benny S, Kleindorfer, Dawn O, Koyfman, Feliks, Lee, Vivien H, Leung, Lester Y, Linares, Guillermo, Linfante, Italo, Lutsep, Helmi L, Macdougall, Lisa, Male, Shailesh, Malik, Amer, Masoud, Hesham, McDermott, Molly, Mehta, Brijesh P, Min, Jiangyong, Mittal, Manoj, Morris, Jane G, Multani, Sumeet S, Nahab, Fadi, Nalleballe, Krishna, Nguyen, Claude B, Novakovic-White, Roberta, Ortega-Gutierrez, Santiago, Rahangdale, Rahul H, Ramakrishnan, Pankajavalli, Romero, Jose Rafael, Rost, Natalia, Rothstein, Aaron, Ruland, Sean, Shah, Ruchir, Sharma, Malveeka, Silver, Brian, Simmons, Marc, Singh, Abhishek, Starosciak, Amy K, Strasser, Sheryl L, Szeder, Viktor, Teleb, Mohamed, Tsai, Jenny P, Voetsch, Barbara, Balaguera, Oscar, Pujol Lereis, Virginia A, Luraschi, Adriana, Almeida, Marcele Schettini, Cardoso, Fabricio Buchdid, Conforto, Adriana, De Deus Silva, Leonardo, Giacomini, Luidia Varrone, Lima, Fabricio Oliveira, Longo, Alexandre L, Magalhães, Pedro Sc, Martins, Rodrigo Targa, Mont'alverne, Francisco, Mora Cuervo, Daissy Liliana, Rebello, Leticia Costa, Valler, Lenise, Zetola, Viviane Flumignan, Lavados, Pablo M, Navia, Victor, Olavarría, Verónica V, Almeida Toro, Juan Manuel, Ricardo Amaya, Pablo Felipe, Bayona, Hernan, Corredor-Quintero, Angel Basilio, Rivera Ordonez, Carlos Eduardo, Mantilla Barbosa, Diana Katherine, Lara, Osvaldo, Patiño, Mauricio R, Diaz Escobar, Luis Fernando, Dejesus Melgarejo Farina, Donoband Edson, Villamayor, Analia Cardozo, Zelaya Zarza, Adolfo Javier, Barrientos Iman, Danny Moises, Kadota, Liliana Rodriguez, Campbell, Bruce, Hankey, Graeme J, Hair, Casey, Kleinig, Timothy, Ma, Alice, Martins, Rodrigo Tomazini, Sahathevan, Ramesh, Thijs, Vincent, Salazar, Daniel, Yuan-Hao Wu, Teddy, Haussen, Diogo C, Liebeskind, David, Yavagal, Dileep, Jovin, Tudor G, Zaidat, Osama O, and Nguyen, Thanh N

Subjects
610 Medicine & health
Abstract

OBJECTIVE The objectives of this study were to measure the global impact of the pandemic on the volumes for intravenous thrombolysis (IVT), IVT transfers, and stroke hospitalizations over 4 months at the height of the pandemic (March 1 to June 30, 2020) compared with two control 4-month periods. METHODS We conducted a cross-sectional, observational, retrospective study across 6 continents, 70 countries, and 457 stroke centers. Diagnoses were identified by their ICD-10 codes and/or classifications in stroke databases. RESULTS There were 91,373 stroke admissions in the 4 months immediately before compared to 80,894 admissions during the pandemic months, representing an 11.5% (95%CI, -11.7 to - 11.3, p

Published
2021
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30. Global impact of the COVID-19 pandemic on stroke care and intravenous thrombolysis

Author

Thanh Nguyen, Phuong, Qureshi, Muhammad, Martins, Sheila, Yamagami, Hiroshi, Qiu, Zhongming, Mansour, Ossama, Czlonkowska, Anna, Abdalkader, Mohamad, Sathya, Anvitha, de Sousa, Diana Aguiar, Demeestere, Jelle, Mikulik, Robert, Vanacker, Peter, Siegler, James, Korv, Janika, Biller, Jose, Liang, Conrad, Sangha, Navdeep, Zha, Alicia, Czap, Alexandra, Holmstedt, Christine, Turan, Tanya, Grant, Cheryl, Ntaios, George, Malhotra, Konard, Tayal, Ashis, Loochtan, Aaron, Mistry, Eva, Alexandrov, Anne, Huang, David, Yaghi, Shadi, Raz, Eytan, Sheth, Sunil, Frankel, Michael, Lamou, Eric Gueumekane Bila, Aref, Hany, Elbassiouny, Ahmed, Hassan, Farouk, Mustafa, Wessam, Menecie, Tarek, Shokri, Hossam, Roushdy, Tamer, Sarfo, Fred Stephen, Alabi, Tolulope, Arabambi, Babawale, Nwazor, Ernest, Sunmonu, Taofiki Ajao, Wahab, Kolawole W., Mohammed, Haythem Hussein, Adebayo, Philip B., Riahi, Anis, Ben Sassi, Samia, Gwaunza, Lenon, Rahman, Aminur, Ai, Zhibing, Bai, Fanghui, Duan, Zhenhui, Hao, Yonggang, Huang, Wenguo, Li, Guangwen, Li, Wei, Liu, Ganzhe, Luo, Jun, Shang, Xianjin, Sui, Yi, Tian, Ling, Wen, Hongbin, Wu, Bo, Yan, Yuying, Yuan, Zhengzhou, Zhang, Hao, Zhang, Jun, Zhao, Wenlong, Zi, Wenjie, Leung, Thomas K., Sahakyan, David, Chugh, Chandril, Huded, Vikram, Menon, Bindu, Pandian, Jeyaraj, Sylaja, P. N., Usman, Fritz Sumantri, Farhoudi, Mehdi, Sadeghi-Hokmabadi, Elyar, Reznik, Anna, Sivan-Hoffman, Rotem, Horev, Anat, Ohara, Nobuyuki, Sakai, Nobuyuki, Watanabe, Daisuke, Yamamoto, Ryoo, Doijiri, Ryosuke, Tokuda, Naoki, Yamada, Takehiro, Terasaki, Tadashi, Yazawa, Yukako, Uwatoko, Takeshi, Dembo, Tomohisa, Shimizu, Hisao, Sugiura, Yuri, Miyashita, Fumio, Fukuda, Hiroki, Miyake, Kosuke, Shimbo, Junsuke, Sugimura, Yusuke, Yagita, Yoshika, Takenobu, Yohei, Matsumaru, Yuji, Yamada, Satoshi, Kono, Ryuhei, Kanamaru, Takuya, Yamazaki, Hidekazu, Sakaguchi, Manabu, Todo, Kenichi, Yamamoto, Nobuaki, Sonodda, Kazutaka, Yoshida, Tomoko, Hashimoto, Hiroyuki, Nakahara, Ichiro, Faizullina, Kamila, Kamenova, Saltanat, Kondybayeva, Aida, Zhanuzakov, Murat, Baek, Jang-Hyun, Hwang, Yangha, Lee, Si Baek, Moon, Jusun, Park, Hyungjong, Seo, Jung Hwa, Seo, Kwon-Duk, Young, Chang Jun, Ahdab, Rechdi, Aziz, Zariah Abdul, Zaidi, Wan Asyraf Wan, Bin Basri, Hamidon, Chung, Law Wan, Husin, Mazlina, Ibrahim, Aznita Binti, Ibrahim, Khairul Azmi, Looi, Irene, Tan, Wee Yong, Yahya, Wan Nur Nafisah Wan, Groppa, Stanislav, Leahu, Pavel, Al Hashmi, Amal, Imam, Yehai Z., Akhtar, Naveed, Oliver, Christian, Kandyba, Dmitriy, Alhazzani, Adel, Al-Jehani, Hosam, Tham, Carol Huilian, Mamauag, Marlie Jane, Narayanaswamy, Ram, Chen, Chih-Hao, Tang, Sung-Chun, Churojana, Anchalee, Aykac, Ozlem, Ozdemir, Atilla Ozcan, Hussain, Syed Irteza, John, Seby, Huynh Le Vu, Anh Duc Tran, Huy Hoang Nguyen, Pham Nhu Thong, Nguyen, Thang, Nguyen, Trung, Gattringer, Thomas, Enzinger, Christian, Killer-Oberpfalzer, Monika, Bellante, Flavio, De Blauwe, Sofie, Van Hooren, Geert, De Raedt, Sylvie, Dusart, Anne, Ligot, Noemie, Rutgers, Matthieu, Yperzeele, Laetitia, Alexiev, Filip, Sakelarova, Teodora, Bedekovic, Marina Roje, Budincevic, Hrvoje, Cindric, Igor, Hucika, Zlatko, Ozretic, David, Saric, Majda Seferovic, Pfeifer, Frantisek, Karpowicz, Igor, Cernik, David, Sramek, Martin, Skoda, Miroslav, Hlavacova, Helena, Klecka, Lukas, Koutny, Martin, Vaclavik, Dan, Skoda, Ondrej, Fiksa, Jan, Hanelova, Katerina, Nevsimalova, Miroslava, Rezek, Robert, Prochazka, Petr, Krejstova, Gabriela, Neumann, Jiri, Vachova, Marta, Brzezanski, Henry, Hlinovsky, David, Tenora, Dusan, Jura, Rene, Jurak, Lubomir, Novak, Jan, Novak, Ales, Topinka, Zdenek, Fibrich, Petr, Sobolova, Helena, Volny, Ondrej, Christensen, Hanne Krarup, Drenck, Nicolas, Iversen, Helle, Simonsen, Claus, Truelsen, Thomas, Wienecke, Troels, Vibo, Riina, Gross-Paju, Katrin, Toomsoo, Toomas, Antsov, Katrin, Caparros, Francois, Cordonnier, Charlotte, Dan, Maria, Faucheux, Jean-Marc, Mechtouff, Laura, Eker, Omer, Lesaine, Emillie, Ondze, Basile, Pico, Fernando, Pop, Raoul, Rouanet, Francois, Gubeladze, Tatuli, Khinikadze, Mirza, Lobjanidze, Nina, Tsiskaridze, Alexander, Nagel, Simon, Ringleb, Peter Arthur, Rosenkranz, Michael, Schmidt, Holger, Sedghi, Annahita, Siepmann, Timo, Szabo, Kristina, Thomalla, Gotz, Palaiodimou, Lina, Sagris, Dimitrios, Kargiotis, Odysseas, Kaliaev, Artem, Liebeskind, David, Hassan, Ameer, Ranta, Anna, Devlin, Thomas, Zaidat, Osama, Castonguay, Alicia, Jovin, Tudor, Tsivgoulis, Georgios, Malik, Amer, Ma, Alice, Campbell, Bruce, Kleinig, Timothy, Wu, Teddy, Gongora, Fernando, Lavados, Pablo, Olavarria, Veronica, Lereis, Virginia Pujol, Corredor, Angel, Barbosa, Diana Mantilla, Bayona, Hernan, Barrientos, Jose Domingo, Patino, Mauricio, Thijs, Vincent, Pirson, Anne, Kristoffersen, Espen Saxhaug, Patrik, Michel, Fischer, Urs, Bernava, Gianmarco, Renieri, Leonardo, Strambo, Davide, Ayo-Martin, Oscar, Montaner, Joan, Karlinski, Michal, Cruz-Culebras, Antonio, Luchowski, Piotr, Krastev, Georgi, Arenillas, Juan, Gralla, Jan, Mangiafico, Salvatore, Blasco, Jordi, Fonseca, Luisa, Silva, M. Luis, Kwan, Joseph, Banerjee, Soma, Sangalli, Davide, Frisullo, Giovanni, Yavagal, Dileep, Uyttenboogaart, Maarten, Bandini, Fabio, Adami, Alessandro, de Lecina, Maria Alonso, Arribas, Miguel Angel Tola, Ferreira, Paulo, Cruz, Vitor Tedim, Nunes, Ana Paiva, Marto, Joao Pedro, Rodrigues, Miguel, Melo, Teresa, Saposnik, Gustavo, Scott, Courtney Anne, Shuaib, Ashfaq, Khosravani, Houman, Fields, Thalia, Shoamanesh, Ashkan, Catanese, Luciana, Mackey, Ariane, Hill, Michael, Etherton, Mark, Rost, Natalia, Lutsep, Helmi, Lee, Vivien, Mehta, Brijesh, Pikula, Aleksandra, Simmons, Marc, Macdougall, Lisa, Silver, Brian, Khandelwal, Priyank, Morris, Jane, Novakovic-White, Roberta, Ramakrishnan, Pankajavalli, Shah, Ruchir, Altschul, Dorothea, Almufti, Fawaz, Amaya, Pablo, Ordonez, Carlos Eduardo Rivera, Lara, Osvalda, Kadota, Liliana Rodriguez, Rivera, Ligia Ibeth Portillo, Novarro, Nelson, Escobar, Luis Diaz, Melgarejo, Donoband, Cardozo, Analia, Blanco, Anmylene, Zelaya, Javier Adolfo, Luraschi, Adriana, Gonzalez, Victor Hugo Navia, Almeida, Juan, Conforto, Adriana, Almeida, Marcele Schettini, Silva, Leonardo de Deus, Cuervo, Daissy Liliana Mora, Zetola, Viviane Flumignan, Martins, Rodrigo Targa, Valler, Lenise, Giacomini, Luidia Varrone, Cardoso, Fabricio Buchdid, Sahathevan, Ramesh, Hair, Casey, Hankey, Graeme, Salazar, Daniel, Lima, Fabricio Oliveira, Mont'Alverne, Francisco, Moises, Danny, Iman, Barrientos, Magalhaes, Pedro, Longo, Alexandre, Rebello, Leticia, Falup-Pecurariu, Cristian, Mazya, Michael, Wisniewska, Anna, Fryze, Waldemar, Kazmierski, Radoslaw, Wisniewska, Malgorzata, Horoch, Ewa, Sienkiewicz-Jarosz, Halina, Fudala, Malgorzata, Rogoziewicz, Marcin, Brola, Waldemar, Sobolewski, Piotr, Kaczorowski, Rafal, Stepien, Adam, Klivenyi, Peter, Szapary, Laszlo, van den Wijngaard, Ido, Demchuk, Andrew, Abraham, Michael, Alvarado-Ortiz, Tony, Kaushal, Ritesh, Ortega-Gutierrez, Santiago, Farooqui, Mudassir, Bach, Ivo, Badruddin, Aamir, Barazangi, Nobl, Nguyen, Claude, Brereton, Charmaine, Choi, Jae H., Dharmadhikari, Sushrut, Desai, Kinjal, Doss, Vinodh, Edgell, Randall, Linares, Guillermo, Frei, Donald, Chaturvedi, Seemant, Gandhi, Dheeraj, Chaudhry, Saqib, Choe, Hana, Grigoryan, Mikayel, Gupta, Rishi, Helenius, Johanna, Voetsch, Barbara, Khwaja, Ayaz, Khoury, Naim, Kim, Benny S., Kleindorfer, Dawn, McDermott, Molly, Koyfman, Feliks, Leung, Lester, Linfante, Italo, Male, Shailesh, Masoud, Hesham, Min, Jiangyong, Mittal, Manoj, Multani, Sumeet, Nahab, Fadi, Nalleballe, Krishna, Rahangdale, Rahul, Rafael, Jose, Rothstein, Aaron, Ruland, Sean, Sharma, Malveeka, Singh, Abishek, Starosciak, Amy, Strasser, Sheryl, Szeder, Viktor, Teleb, Mohamed, Tsai, Jenny, Mohammaden, Mahmoud, Pineda-Franks, Carissa, Asyraf, Wan, Trung Quoch Nguyen, Tarkanyi, Gabor, Haussen, Diogo, Balaguera, Oscar, Vasquez, Alejandro Rodriguez, Nogueira, Raul, Thanh Nguyen, Phuong, Qureshi, Muhammad, Martins, Sheila, Yamagami, Hiroshi, Qiu, Zhongming, Mansour, Ossama, Czlonkowska, Anna, Abdalkader, Mohamad, Sathya, Anvitha, de Sousa, Diana Aguiar, Demeestere, Jelle, Mikulik, Robert, Vanacker, Peter, Siegler, James, Korv, Janika, Biller, Jose, Liang, Conrad, Sangha, Navdeep, Zha, Alicia, Czap, Alexandra, Holmstedt, Christine, Turan, Tanya, Grant, Cheryl, Ntaios, George, Malhotra, Konard, Tayal, Ashis, Loochtan, Aaron, Mistry, Eva, Alexandrov, Anne, Huang, David, Yaghi, Shadi, Raz, Eytan, Sheth, Sunil, Frankel, Michael, Lamou, Eric Gueumekane Bila, Aref, Hany, Elbassiouny, Ahmed, Hassan, Farouk, Mustafa, Wessam, Menecie, Tarek, Shokri, Hossam, Roushdy, Tamer, Sarfo, Fred Stephen, Alabi, Tolulope, Arabambi, Babawale, Nwazor, Ernest, Sunmonu, Taofiki Ajao, Wahab, Kolawole W., Mohammed, Haythem Hussein, Adebayo, Philip B., Riahi, Anis, Ben Sassi, Samia, Gwaunza, Lenon, Rahman, Aminur, Ai, Zhibing, Bai, Fanghui, Duan, Zhenhui, Hao, Yonggang, Huang, Wenguo, Li, Guangwen, Li, Wei, Liu, Ganzhe, Luo, Jun, Shang, Xianjin, Sui, Yi, Tian, Ling, Wen, Hongbin, Wu, Bo, Yan, Yuying, Yuan, Zhengzhou, Zhang, Hao, Zhang, Jun, Zhao, Wenlong, Zi, Wenjie, Leung, Thomas K., Sahakyan, David, Chugh, Chandril, Huded, Vikram, Menon, Bindu, Pandian, Jeyaraj, Sylaja, P. N., Usman, Fritz Sumantri, Farhoudi, Mehdi, Sadeghi-Hokmabadi, Elyar, Reznik, Anna, Sivan-Hoffman, Rotem, Horev, Anat, Ohara, Nobuyuki, Sakai, Nobuyuki, Watanabe, Daisuke, Yamamoto, Ryoo, Doijiri, Ryosuke, Tokuda, Naoki, Yamada, Takehiro, Terasaki, Tadashi, Yazawa, Yukako, Uwatoko, Takeshi, Dembo, Tomohisa, Shimizu, Hisao, Sugiura, Yuri, Miyashita, Fumio, Fukuda, Hiroki, Miyake, Kosuke, Shimbo, Junsuke, Sugimura, Yusuke, Yagita, Yoshika, Takenobu, Yohei, Matsumaru, Yuji, Yamada, Satoshi, Kono, Ryuhei, Kanamaru, Takuya, Yamazaki, Hidekazu, Sakaguchi, Manabu, Todo, Kenichi, Yamamoto, Nobuaki, Sonodda, Kazutaka, Yoshida, Tomoko, Hashimoto, Hiroyuki, Nakahara, Ichiro, Faizullina, Kamila, Kamenova, Saltanat, Kondybayeva, Aida, Zhanuzakov, Murat, Baek, Jang-Hyun, Hwang, Yangha, Lee, Si Baek, Moon, Jusun, Park, Hyungjong, Seo, Jung Hwa, Seo, Kwon-Duk, Young, Chang Jun, Ahdab, Rechdi, Aziz, Zariah Abdul, Zaidi, Wan Asyraf Wan, Bin Basri, Hamidon, Chung, Law Wan, Husin, Mazlina, Ibrahim, Aznita Binti, Ibrahim, Khairul Azmi, Looi, Irene, Tan, Wee Yong, Yahya, Wan Nur Nafisah Wan, Groppa, Stanislav, Leahu, Pavel, Al Hashmi, Amal, Imam, Yehai Z., Akhtar, Naveed, Oliver, Christian, Kandyba, Dmitriy, Alhazzani, Adel, Al-Jehani, Hosam, Tham, Carol Huilian, Mamauag, Marlie Jane, Narayanaswamy, Ram, Chen, Chih-Hao, Tang, Sung-Chun, Churojana, Anchalee, Aykac, Ozlem, Ozdemir, Atilla Ozcan, Hussain, Syed Irteza, John, Seby, Huynh Le Vu, Anh Duc Tran, Huy Hoang Nguyen, Pham Nhu Thong, Nguyen, Thang, Nguyen, Trung, Gattringer, Thomas, Enzinger, Christian, Killer-Oberpfalzer, Monika, Bellante, Flavio, De Blauwe, Sofie, Van Hooren, Geert, De Raedt, Sylvie, Dusart, Anne, Ligot, Noemie, Rutgers, Matthieu, Yperzeele, Laetitia, Alexiev, Filip, Sakelarova, Teodora, Bedekovic, Marina Roje, Budincevic, Hrvoje, Cindric, Igor, Hucika, Zlatko, Ozretic, David, Saric, Majda Seferovic, Pfeifer, Frantisek, Karpowicz, Igor, Cernik, David, Sramek, Martin, Skoda, Miroslav, Hlavacova, Helena, Klecka, Lukas, Koutny, Martin, Vaclavik, Dan, Skoda, Ondrej, Fiksa, Jan, Hanelova, Katerina, Nevsimalova, Miroslava, Rezek, Robert, Prochazka, Petr, Krejstova, Gabriela, Neumann, Jiri, Vachova, Marta, Brzezanski, Henry, Hlinovsky, David, Tenora, Dusan, Jura, Rene, Jurak, Lubomir, Novak, Jan, Novak, Ales, Topinka, Zdenek, Fibrich, Petr, Sobolova, Helena, Volny, Ondrej, Christensen, Hanne Krarup, Drenck, Nicolas, Iversen, Helle, Simonsen, Claus, Truelsen, Thomas, Wienecke, Troels, Vibo, Riina, Gross-Paju, Katrin, Toomsoo, Toomas, Antsov, Katrin, Caparros, Francois, Cordonnier, Charlotte, Dan, Maria, Faucheux, Jean-Marc, Mechtouff, Laura, Eker, Omer, Lesaine, Emillie, Ondze, Basile, Pico, Fernando, Pop, Raoul, Rouanet, Francois, Gubeladze, Tatuli, Khinikadze, Mirza, Lobjanidze, Nina, Tsiskaridze, Alexander, Nagel, Simon, Ringleb, Peter Arthur, Rosenkranz, Michael, Schmidt, Holger, Sedghi, Annahita, Siepmann, Timo, Szabo, Kristina, Thomalla, Gotz, Palaiodimou, Lina, Sagris, Dimitrios, Kargiotis, Odysseas, Kaliaev, Artem, Liebeskind, David, Hassan, Ameer, Ranta, Anna, Devlin, Thomas, Zaidat, Osama, Castonguay, Alicia, Jovin, Tudor, Tsivgoulis, Georgios, Malik, Amer, Ma, Alice, Campbell, Bruce, Kleinig, Timothy, Wu, Teddy, Gongora, Fernando, Lavados, Pablo, Olavarria, Veronica, Lereis, Virginia Pujol, Corredor, Angel, Barbosa, Diana Mantilla, Bayona, Hernan, Barrientos, Jose Domingo, Patino, Mauricio, Thijs, Vincent, Pirson, Anne, Kristoffersen, Espen Saxhaug, Patrik, Michel, Fischer, Urs, Bernava, Gianmarco, Renieri, Leonardo, Strambo, Davide, Ayo-Martin, Oscar, Montaner, Joan, Karlinski, Michal, Cruz-Culebras, Antonio, Luchowski, Piotr, Krastev, Georgi, Arenillas, Juan, Gralla, Jan, Mangiafico, Salvatore, Blasco, Jordi, Fonseca, Luisa, Silva, M. Luis, Kwan, Joseph, Banerjee, Soma, Sangalli, Davide, Frisullo, Giovanni, Yavagal, Dileep, Uyttenboogaart, Maarten, Bandini, Fabio, Adami, Alessandro, de Lecina, Maria Alonso, Arribas, Miguel Angel Tola, Ferreira, Paulo, Cruz, Vitor Tedim, Nunes, Ana Paiva, Marto, Joao Pedro, Rodrigues, Miguel, Melo, Teresa, Saposnik, Gustavo, Scott, Courtney Anne, Shuaib, Ashfaq, Khosravani, Houman, Fields, Thalia, Shoamanesh, Ashkan, Catanese, Luciana, Mackey, Ariane, Hill, Michael, Etherton, Mark, Rost, Natalia, Lutsep, Helmi, Lee, Vivien, Mehta, Brijesh, Pikula, Aleksandra, Simmons, Marc, Macdougall, Lisa, Silver, Brian, Khandelwal, Priyank, Morris, Jane, Novakovic-White, Roberta, Ramakrishnan, Pankajavalli, Shah, Ruchir, Altschul, Dorothea, Almufti, Fawaz, Amaya, Pablo, Ordonez, Carlos Eduardo Rivera, Lara, Osvalda, Kadota, Liliana Rodriguez, Rivera, Ligia Ibeth Portillo, Novarro, Nelson, Escobar, Luis Diaz, Melgarejo, Donoband, Cardozo, Analia, Blanco, Anmylene, Zelaya, Javier Adolfo, Luraschi, Adriana, Gonzalez, Victor Hugo Navia, Almeida, Juan, Conforto, Adriana, Almeida, Marcele Schettini, Silva, Leonardo de Deus, Cuervo, Daissy Liliana Mora, Zetola, Viviane Flumignan, Martins, Rodrigo Targa, Valler, Lenise, Giacomini, Luidia Varrone, Cardoso, Fabricio Buchdid, Sahathevan, Ramesh, Hair, Casey, Hankey, Graeme, Salazar, Daniel, Lima, Fabricio Oliveira, Mont'Alverne, Francisco, Moises, Danny, Iman, Barrientos, Magalhaes, Pedro, Longo, Alexandre, Rebello, Leticia, Falup-Pecurariu, Cristian, Mazya, Michael, Wisniewska, Anna, Fryze, Waldemar, Kazmierski, Radoslaw, Wisniewska, Malgorzata, Horoch, Ewa, Sienkiewicz-Jarosz, Halina, Fudala, Malgorzata, Rogoziewicz, Marcin, Brola, Waldemar, Sobolewski, Piotr, Kaczorowski, Rafal, Stepien, Adam, Klivenyi, Peter, Szapary, Laszlo, van den Wijngaard, Ido, Demchuk, Andrew, Abraham, Michael, Alvarado-Ortiz, Tony, Kaushal, Ritesh, Ortega-Gutierrez, Santiago, Farooqui, Mudassir, Bach, Ivo, Badruddin, Aamir, Barazangi, Nobl, Nguyen, Claude, Brereton, Charmaine, Choi, Jae H., Dharmadhikari, Sushrut, Desai, Kinjal, Doss, Vinodh, Edgell, Randall, Linares, Guillermo, Frei, Donald, Chaturvedi, Seemant, Gandhi, Dheeraj, Chaudhry, Saqib, Choe, Hana, Grigoryan, Mikayel, Gupta, Rishi, Helenius, Johanna, Voetsch, Barbara, Khwaja, Ayaz, Khoury, Naim, Kim, Benny S., Kleindorfer, Dawn, McDermott, Molly, Koyfman, Feliks, Leung, Lester, Linfante, Italo, Male, Shailesh, Masoud, Hesham, Min, Jiangyong, Mittal, Manoj, Multani, Sumeet, Nahab, Fadi, Nalleballe, Krishna, Rahangdale, Rahul, Rafael, Jose, Rothstein, Aaron, Ruland, Sean, Sharma, Malveeka, Singh, Abishek, Starosciak, Amy, Strasser, Sheryl, Szeder, Viktor, Teleb, Mohamed, Tsai, Jenny, Mohammaden, Mahmoud, Pineda-Franks, Carissa, Asyraf, Wan, Trung Quoch Nguyen, Tarkanyi, Gabor, Haussen, Diogo, Balaguera, Oscar, Vasquez, Alejandro Rodriguez, and Nogueira, Raul

Published
2021

31. Global impact of the COVID-19 pandemic on stroke care and intravenous thrombolysis (1462)

Author

Nguyen, Thanh, primary, Qureshi, Muhammad, additional, Martins, Sheila, additional, Yamagami, Hiroshi, additional, Qiu, Zhongming, additional, Mansour, Ossama, additional, Czlonkowska, Anna, additional, Abdalkader, Mohamad, additional, Sathya, Anvitha, additional, de Sousa, Diana Aguiar, additional, Demeestere, Jelle, additional, Mikulik, Robert, additional, Vanacker, Peter, additional, Siegler, James, additional, Korv, Janika, additional, Biller, Jose, additional, Liang, Conrad, additional, Sangha, Navdeep, additional, Zha, Alicia, additional, Czap, Alexandra, additional, Holmstedt, Christine, additional, Turan, Tanya, additional, Grant, Cheryl, additional, Ntaios, George, additional, Malhotra, Konard, additional, Tayal, Ashis, additional, Loochtan, Aaron, additional, Mistry, Eva, additional, Alexandrov, Anne, additional, Huang, David, additional, Yaghi, Shadi, additional, Raz, Eytan, additional, Sheth, Sunil, additional, Frankel, Michael, additional, Lamou, Eric Gueumekane Bila, additional, Aref, Hany, additional, Elbassiouny, Ahmed, additional, Hassan, Farouk, additional, Mustafa, Wessam, additional, Menecie, Tarek, additional, Shokri, Hossam, additional, Roushdy, Tamer, additional, Sarfo, Fred Stephen, additional, Alabi, Tolulope, additional, Arabambi, Babawale, additional, Nwazor, Ernest, additional, Sunmonu, Taofiki Ajao, additional, Wahab, Kolawole W., additional, Mohammed, Haythem Hussein, additional, Adebayo, Philip B., additional, Riahi, Anis, additional, Ben Sassi, Samia, additional, Gwaunza, Lenon, additional, Rahman, Aminur, additional, Ai, Zhibing, additional, Bai, Fanghui, additional, Duan, Zhenhui, additional, Hao, Yonggang, additional, Huang, Wenguo, additional, Li, Guangwen, additional, Li, Wei, additional, Liu, Ganzhe, additional, Luo, Jun, additional, Shang, Xianjin, additional, Sui, Yi, additional, Tian, Ling, additional, Wen, Hongbin, additional, Wu, Bo, additional, Yan, Yuying, additional, Yuan, Zhengzhou, additional, Zhang, Hao, additional, Zhang, Jun, additional, Zhao, Wenlong, additional, Zi, Wenjie, additional, Leung, Thomas K., additional, Sahakyan, David, additional, Chugh, Chandril, additional, Huded, Vikram, additional, Menon, Bindu, additional, Pandian, Jeyaraj, additional, Sylaja, P.N., additional, Usman, Fritz Sumantri, additional, Farhoudi, Mehdi, additional, Sadeghi-Hokmabadi, Elyar, additional, Reznik, Anna, additional, Sivan-Hoffman, Rotem, additional, Horev, Anat, additional, Ohara, Nobuyuki, additional, Sakai, Nobuyuki, additional, Watanabe, Daisuke, additional, Yamamoto, Ryoo, additional, Doijiri, Ryosuke, additional, Tokuda, Naoki, additional, Yamada, Takehiro, additional, Terasaki, Tadashi, additional, Yazawa, Yukako, additional, Uwatoko, Takeshi, additional, Dembo, Tomohisa, additional, Shimizu, Hisao, additional, Sugiura, Yuri, additional, Miyashita, Fumio, additional, Fukuda, Hiroki, additional, Miyake, Kosuke, additional, Shimbo, Junsuke, additional, Sugimura, Yusuke, additional, Yagita, Yoshika, additional, Takenobu, Yohei, additional, Matsumaru, Yuji, additional, Yamada, Satoshi, additional, Kono, Ryuhei, additional, Kanamaru, Takuya, additional, Yamazaki, Hidekazu, additional, Sakaguchi, Manabu, additional, Todo, Kenichi, additional, Yamamoto, Nobuaki, additional, Sonodda, Kazutaka, additional, Yoshida, Tomoko, additional, Hashimoto, Hiroyuki, additional, Nakahara, Ichiro, additional, Faizullina, Kamila, additional, Kamenova, Saltanat, additional, Kondybayeva, Aida, additional, Zhanuzakov, Murat, additional, Baek, Jang-Hyun, additional, Hwang, Yangha, additional, Lee, Si Baek, additional, Moon, Jusun, additional, Park, Hyungjong, additional, Seo, Jung Hwa, additional, Seo, Kwon-Duk, additional, Young, Chang Jun, additional, Ahdab, Rechdi, additional, Aziz, Zariah Abdul, additional, Zaidi, Wan Asyraf Wan, additional, Basri, Hamidon Bin, additional, Chung, Law Wan, additional, Husin, Mazlina, additional, Ibrahim, Aznita Binti, additional, Ibrahim, Khairul Azmi, additional, Looi, Irene, additional, Tan, Wee Yong, additional, Yahya, Wan Nur Nafisah Wan, additional, Groppa, Stanislav, additional, Leahu, Pavel, additional, Al Hashmi, Amal, additional, Imam, Yehai Z., additional, Akhtar, Naveed, additional, Oliver, Christian, additional, Kandyba, Dmitriy, additional, Alhazzani, Adel, additional, Al-Jehani, Hosam, additional, Tham, Carol Huilian, additional, Mamauag, Marlie Jane, additional, Narayanaswamy, Ram, additional, Chen, Chih-Hao, additional, Tang, Sung-Chun, additional, Churojana, Anchalee, additional, Aykaç, Ozlem, additional, Özdemir, Atilla Özcan, additional, Hussain, Syed Irteza, additional, John, Seby, additional, Le Vu, Huynh, additional, Tran, Anh Duc, additional, Nguyen, Huy Hoang, additional, Thong, Pham Nhu, additional, Nguyen, Thang, additional, Nguyen, Trung, additional, Gattringer, Thomas, additional, Enzinger, Christian, additional, Killer-Oberpfalzer, Monika, additional, Bellante, Flavio, additional, De Blauwe, Sofie, additional, Van Hooren, Geert, additional, De Raedt, Sylvie, additional, Dusart, Anne, additional, Ligot, Noemie, additional, Rutgers, Matthieu, additional, Yperzeele, Laetitia, additional, Alexiev, Filip, additional, Sakelarova, Teodora, additional, Bedekovic, Marina Roje, additional, Budincevic, Hrvoje, additional, Cindric, Igor, additional, Hucika, Zlatko, additional, Ozretic, David, additional, Saric, Majda Seferovic, additional, Pfeifer, František, additional, Karpowicz, Igor, additional, Cernik, David, additional, Sramek, Martin, additional, Skoda, Miroslav, additional, Hlavacova, Helena, additional, Klecka, Lukas, additional, Koutny, Martin, additional, Vaclavik, Dan, additional, Skoda, Ondrej, additional, Fiksa, Jan, additional, Hanelova, Katerina, additional, Nevsimalova, Miroslava, additional, Rezek, Robert, additional, Prochazka, Petr, additional, Krejstova, Gabriela, additional, Neumann, Jiri, additional, Vachova, Marta, additional, Brzezanski, Henry, additional, Hlinovsky, David, additional, Tenora, Dusan, additional, Jura, Rene, additional, Jurak, Lubomir, additional, Novak, Jan, additional, Novak, Ales, additional, Topinka, Zdenek, additional, Fibrich, Petr, additional, Sobolova, Helena, additional, Volny, Ondrej, additional, Christensen, Hanne Krarup, additional, Drenck, Nicolas, additional, Iversen, Helle, additional, Simonsen, Claus, additional, Truelsen, Thomas, additional, Wienecke, Troels, additional, Vibo, Riina, additional, Gross-Paju, Katrin, additional, Toomsoo, Toomas, additional, Antsov, Katrin, additional, Caparros, Francois, additional, Cordonnier, Charlotte, additional, Dan, Maria, additional, Faucheux, Jean-Marc, additional, Mechtouff, Laura, additional, Eker, Omer, additional, Lesaine, Emillie, additional, Ondze, Basile, additional, Pico, Fernando, additional, Pop, Raoul, additional, Rouanet, Francois, additional, Gubeladze, Tatuli, additional, Khinikadze, Mirza, additional, Lobjanidze, Nina, additional, Tsiskaridze, Alexander, additional, Nagel, Simon, additional, Ringleb, Peter Arthur, additional, Rosenkranz, Michael, additional, Schmidt, Holger, additional, Sedghi, Annahita, additional, Siepmann, Timo, additional, Szabo, Kristina, additional, Thomalla, Gotz, additional, Palaiodimou, Lina, additional, Sagris, Dimitrios, additional, Kargiotis, Odysseas, additional, Kaliaev, Artem, additional, Liebeskind, David, additional, Hassan, Ameer, additional, Ranta, Anna, additional, Devlin, Thomas, additional, Zaidat, Osama, additional, Castonguay, Alicia, additional, Jovin, Tudor, additional, Tsivgoulis, Georgios, additional, Malik, Amer, additional, Ma, Alice, additional, Campbell, Bruce, additional, Kleinig, Timothy, additional, Wu, Teddy, additional, Gongora, Fernando, additional, Lavados, Pablo, additional, Olavarria, Veronica, additional, Lereis, Virginia Pujol, additional, Corredor, Angel, additional, Barbosa, Diana Mantilla, additional, Bayona, Hernan, additional, Barrientos, Jose Domingo, additional, Patino, Mauricio, additional, Thijs, Vincent, additional, Pirson, Anne, additional, Kristoffersen, Espen Saxhaug, additional, Patrik, Michel, additional, Fischer, Urs, additional, Bernava, Gianmarco, additional, Renieri, Leonardo, additional, Strambo, Davide, additional, Ayo-Martin, Oscar, additional, Montaner, Joan, additional, Karlinski, Michal, additional, Cruz-Culebras, Antonio, additional, Luchowski, Piotr, additional, Krastev, Georgi, additional, Arenillas, Juan, additional, Gralla, Jan, additional, Mangiafico, Salvatore, additional, Blasco, Jordi, additional, Fonseca, Luisa, additional, Silva, M. Luis, additional, Kwan, Joseph, additional, Banerjee, Soma, additional, Sangalli, Davide, additional, Frisullo, Giovanni, additional, Yavagal, Dileep, additional, Uyttenboogaart, Maarten, additional, Bandini, Fabio, additional, Adami, Alessandro, additional, de Lecina, Maria Alonso, additional, Arribas, Miguel Angel Tola, additional, Ferreira, Paulo, additional, Cruz, Vitor Tedim, additional, Nunes, Ana Paiva, additional, Marto, Joao Pedro, additional, Rodrigues, Miguel, additional, Melo, Teresa, additional, Saposnik, Gustavo, additional, Scott, Courtney Anne, additional, Shuaib, Ashfaq, additional, Khosravani, Houman, additional, Fields, Thalia, additional, Shoamanesh, Ashkan, additional, Catanese, Luciana, additional, Mackey, Ariane, additional, Hill, Michael, additional, Etherton, Mark, additional, Rost, Natalia, additional, Lutsep, Helmi, additional, Lee, Vivien, additional, Mehta, Brijesh, additional, Pikula, Aleksandra, additional, Simmons, Marc, additional, Macdougall, Lisa, additional, Silver, Brian, additional, Khandelwal, Priyank, additional, Morris, Jane, additional, Novakovic-White, Roberta, additional, Ramakrishnan, Pankajavalli, additional, Shah, Ruchir, additional, Altschul, Dorothea, additional, Almufti, Fawaz, additional, Amaya, Pablo, additional, Ordonez, Carlos Eduardo Rivera, additional, Lara, Osvalda, additional, Kadota, Liliana Rodriguez, additional, Rivera, Ligia Ibeth Portillo, additional, Novarro, Nelson, additional, Escobar, Luis Diaz, additional, Melgarejo, Donoband, additional, Cardozo, Analia, additional, Blanco, Anmylene, additional, Zelaya, Javier Adolfo, additional, Luraschi, Adriana, additional, Gonzalez, Victor Hugo Navia, additional, Almeida, Juan, additional, Conforto, Adriana, additional, Almeida, Marcele Schettini, additional, de Deus Silva, Leonardo, additional, Cuervo, Daissy Liliana Mora, additional, Zetola, Viviane Flumignan, additional, Martins, Rodrigo Targa, additional, Valler, Lenise, additional, Giacomini, Luidia Varrone, additional, Cardoso, Fabricio Buchdid, additional, Sahathevan, Ramesh, additional, Hair, Casey, additional, Hankey, Graeme, additional, Salazar, Daniel, additional, Lima, Fabricio Oliveira, additional, Mont’Alverne, Francisco, additional, Iman, Danny Moises Barrientos, additional, Magalhaes, Pedro, additional, Longo, Alexandre, additional, Rebello, Leticia, additional, Falup-Pecurariu, Cristian, additional, Mazya, Michael, additional, Wisniewska, Anna, additional, Fryze, Waldemar, additional, Kazmierski, Radoslaw, additional, Wisniewska, Malgorzata, additional, Horoch, Ewa, additional, Sienkiewicz-Jarosz, Halina, additional, Fudala, Malgorzata, additional, Rogoziewicz, Marcin, additional, Brola, Waldemar, additional, Sobolewski, Piotr, additional, Kaczorowski, Rafal, additional, Stepien, Adam, additional, Klivenyi, Peter, additional, Szapary, Laszlo, additional, van den Wijngaard, Ido, additional, Demchuk, Andrew, additional, Abraham, Michael, additional, Alvarado-Ortiz, Tony, additional, Kaushal, Ritesh, additional, Ortega-Gutierrez, Santiago, additional, Farooqui, Mudassir, additional, Bach, Ivo, additional, Badruddin, Aamir, additional, Barazangi, Nobl, additional, Nguyen, Claude, additional, Brereton, Charmaine, additional, Choi, Jae H., additional, Dharmadhikari, Sushrut, additional, Desai, Kinjal, additional, Doss, Vinodh, additional, Edgell, Randall, additional, Linares, Guillermo, additional, Frei, Donald, additional, Chaturvedi, Seemant, additional, Gandhi, Dheeraj, additional, Chaudhry, Saqib, additional, Choe, Hana, additional, Grigoryan, Mikayel, additional, Gupta, Rishi, additional, Helenius, Johanna, additional, Voetsch, Barbara, additional, Khwaja, Ayaz, additional, Khoury, Naim, additional, Kim, Benny S., additional, Kleindorfer, Dawn, additional, McDermott, Molly, additional, Koyfman, Feliks, additional, Leung, Lester, additional, Linfante, Italo, additional, Male, Shailesh, additional, Masoud, Hesham, additional, Min, Jiangyong, additional, Mittal, Manoj, additional, Multani, Sumeet, additional, Nahab, Fadi, additional, Nalleballe, Krishna, additional, Rahangdale, Rahul, additional, Rafael, Jose, additional, Rothstein, Aaron, additional, Ruland, Sean, additional, Sharma, Malveeka, additional, Singh, Abishek, additional, Starosciak, Amy, additional, Strasser, Sheryl, additional, Szeder, Viktor, additional, Teleb, Mohamed, additional, Tsai, Jenny, additional, Mohammaden, Mahmoud, additional, Pineda-Franks, Carissa, additional, Asyraf, Wan, additional, Nguyen, Trung QuocH, additional, Tarkanyi, Gabor, additional, Haussen, Diogo, additional, Balaguera, Oscar, additional, Vasquez, Alejandro Rodriguez, additional, and Nogueira, Raul, additional

Published
2021
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32. Experimental evaluation of direct thromboaspiration efficacy according to the angle of interaction between the aspiration catheter and the clot

Author

Bernava, Gianmarco, primary, Rosi, Andrea, additional, Boto, José, additional, Hofmeister, Jeremy, additional, Brina, Olivier, additional, Reymond, Philippe, additional, Muster, Michel, additional, Yilmaz, Hasan, additional, Kulcsar, Zsolt, additional, Carrera, Emmanuel, additional, Bouri, Mohamed, additional, Lovblad, Karl-Olof, additional, and Machi, Paolo, additional

Published
2021
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35. IER-SICH Nomogram to Predict Symptomatic Intracerebral Hemorrhage After Thrombectomy for Stroke

Author

Cappellari, Manuel, Mangiafico, Salvatore, Saia, Valentina, Pracucci, Giovanni, Nappini, Sergio, Nencini, Patrizia, Konda, Daniel, Sallustio, Fabrizio, Vallone, Stefano, Zini, Andrea, Bracco, Sandra, Tassi, Rossana, Bergui, Mauro, Cerrato, Paolo, Pitrone, Antonio, Grillo, Francesco, Saletti, Andrea, De Vito, Alessandro, Gasparotti, Roberto, Magoni, Mauro, Puglielli, Edoardo, Casalena, Alfonsina, Causin, Francesco, Baracchini, Claudio, Castellan, Lucio, Malfatto, Laura, Menozzi, Roberto, Scoditti, Umberto, Comelli, Chiara, Duc, Enrica, Comai, Alessio, Franchini, Enrica, Cosottini, Mirco, Mancuso, Michelangelo, Peschillo, Simone, De Michele, Manuela, Giorgianni, Andrea, Delodovici, Maria Luisa, Lafe, Elvis, Denaro, Maria Federica, Burdi, Nicola, Internò, Saverio, Cavasin, Nicola, Critelli, Adriana, Chiumarulo, Luigi, Petruzzellis, Marco, Doddi, Marco, Carolei, Antonio, Auteri, William, Petrone, Alfredo, Padolecchia, Riccardo, Tassinari, Tiziana, Pavia, Marco, Invernizzi, Paolo, Turcato, Gianni, Forlivesi, Stefano, Ciceri, Elisa Francesca Maria, Bonetti, Bruno, Inzitari, Domenico, Toni, Danilo, Limbucci, Nicola, Consoli, Arturo, Renieri, Leonardo, Fainardi, Enrico, Gandini, Roberto, Pampana, Enrico, Diomedi, Marina, Koch, Giacomo, Verganti, Luca, Sacchetti, Federico, Zelent, Gabriele, Bigliardi, Guido, Picchetto, Livio, Vandelli, Laura, Romano, Daniele Giuseppe, Cioni, Samuele, Gennari, Paola, Cerase, Alfonso, Martini, Giuseppe, Stura, Guido, Daniele, Dino, Naldi, Andrea, Papa, Rosario, Vinci, Sergio Lucio, Bernava, Gianmarco, Velo, Mariano, Caragliano, Antonio, Tessitore, Agostino, Buonomo, Orazio, Musolino, Rossella, La Spina, Paolino, Casella, Carmela, Carolina Fazio, Maria, Cotroneo, Masina, Onofrio, Marcello, Azzini, Cristiano, Casetta, Ilaria, Mardighian, Dikran, Frigerio, Michele, Costa, Angelo, Di Egidio, Vincenzo, Lattanzi, Ruggero, Assetta, Maurizio, Cester, Giacomo, Mavilio, Nicola, Serrati, Carlo, Piazza, Paolo, Epifani, Enrico, Andreone, Andrea, Castellini, Paola, Latte, Lilia, Grisendi, Ilaria, Vaudano, Giacomo, Comelli, Simone, Cavallo, Roberto, Chianale, Gigliola, Simonetti, Luigi, Taglialatela, Francesco, Isceri, Salvatore, Procaccianti, Gaetano, Zaniboni, Anna, Borghi, Annamaria, Bonatti, Giampietro, Ferro, Federica, Bonatti, Matteo, Dall’Ora, Elisa, Currò Dossi, Roberto, Turri, Emanuela, Turri, Mara, Puglioli, Michele, Lazzarotti, Guido, Lauretti, DARIO LUCA, Giannini, Nicola, Maccarone, Miriam, Orlandi, Giovanni, Chiti, Alberto, Guidetti, Giulio, Biraschi, Francesco, Falcou, Anne, Anzini, Alexia, Mancini, Alessandra, Fausti, Silvia, Di Mascio, Maria Teresa, Durastanti, Laura, Sbardella, Emilia, Mellina, Vittorio, Baruzzi, Fabio, Pellegrino, Carlo, Terrana, Alberto, Carimati, Federico, Ruggiero, Maria, Sanna, Antioco, Passarin, Maria Grazia, Colosimo, Cesare, Pedicelli, Alessandro, D’Argento, Francesco, Alexandre, Andrea, Frisullo, Giovanni, Zappoli, Federico, Martignoni, Alessandra, Cavallini, Anna, Persico, Alessandra, Valvassori, Luca, Piano, Mariangela, Agostoni, Elio, Motto, Cristina, Gatti, Antonella, Longoni, Marco, Guccione, Angelo, Tortorella, Rachele, Zampieri, Piergiuseppe, Zimatore, Domenico Sergio, Grazioli, Andrea, Ricciardi, Giuseppe Kenneth, Augelli, Raffaele, Bovi, Paolo, Tomelleri, Giampaolo, Micheletti, Nicola, Semeraro, Vittorio, Lucarelli, Nicola, Ganimede, Maria, Tinelli, Angelica, Pia Prontera, Maria, Pesare, Angela, Cagliari, Enrico, Quatrale, Rocco, Federico, Francesco, Passalacqua, Giovanni, Filauri, Pietro, Orlandi, Berardino, De Santis, Federica, Gabriele, Amleto, Tiseo, Cindy, Armentano, Antonio, Di Benedetto, Olindo, Silvagni, Umberto, Perrotta, Paolo, Crispino, Emanuela, Stancati, Furio, Rizzuto, Stefano, Pugliese, Pierfrancesco, Pisani, Ermanno, Siniscalchi, Antonio, Gaudiano, Carmen, Pirritano, Domenico, Del Giudice, Francesco, Calia, Stefano, Ganci, Giuseppe, Sugo, Annalisa, Scomazzoni, Francesco, Simionato, Franco, Roveri, Luisa, De Nicola, Maurizio, Giannoni, Mirko, Bruni, Stefano, Gambelli, Elena, Provinciali, Leandro, Carriero, Alessandro, Coppo, Lorenzo, Baldan, Julika, Paolo Nuzzi, Nunzio, Marcheselli, Simona, Corato, Manuel, Cotroneo, Enrico, Ricciardi, Fabrizio, Gigli, Renato, Pozzessere, Claudio, Pezzella, Francesca Romana, Corsi, Fabio, Squassina, Guido, Cobelli, Milena, Morassi, Mauro, Magni, Eugenio, Pepe, Fulvio, Bigni, Barbara, Costa, Paolo, Crabbio, Massimo, Griffini, Simona, Palmerini, Francesco, Piras, Maria Paola, Natrella, Massimiliano, Fanelli, Gianluca, Cristoferi, Massimo, Bottacchi, Edo, Corso, Giovanni, Tosi, Piera, Amistà, Pietro, Russo, Monia, Tettoni, Serena, Gallesio, Ivan, Mascolo, Maria Carmela, Meloni, Giovanni Battista, Fabio, Claudio, Maiore, Mario, Pintus, Francesco, Pischedda, Aldo, Manca, Antonio, Mongili, Claudia, Zanda, Bastianina, Sanna, Antonella, Baule, Antonio, Pappalardo, Maria Pia, Craparo, Giuseppe, Gallo, Cristina, Monaco, Serena, Mannino, Marina, Terruso, Valeria, Muto, Mario, Guarnieri, Gianluigi, Andreone, Vincenzo, Dui, Giovanni, Ticca, Anna, Salmaggi, Andrea, Iannucci, Giuseppe, Pinna, Vittore, Di Clemente, Loris, Perini, Francesco, De Boni, Antonella, De Luca, Cristina, De Giorgi, Franco, Corraine, Simona, Enne, Paolo, Ganau, Claudio, and Piras, Valeria

Subjects
Male, medicine.medical_specialty, Fibrinolytic Agents/therapeutic use Humans Male Middle Aged *Nomograms Postoperative Complications/etiology Risk Assessment Risk Factors Stroke/complications/drug therapy/*surgery Thrombectomy/*adverse effects Thrombolytic Therapy/adverse effects, medicine.medical_treatment, contraindications, Risk Assessment, NO, Brain Ischemia, Brain ischemia, Postoperative Complications, Fibrinolytic Agents, Risk Factors, contraindications ◼ logistic models ◼ nomograms ◼ standard of care ◼ thrombectomy, medicine, 80 and over, Humans, Thrombolytic Therapy, Stroke, contraindications, logistic models, nomograms, standard of care, thrombectomy, Aged, Cerebral Hemorrhage, Aged, 80 and over, Advanced and Specialized Nursing, Intracerebral hemorrhage, Receiver operating characteristic, business.industry, Thrombolysis, Nomogram, Middle Aged, medicine.disease, logistic models, nomograms, standard of care, thrombectomy, Female, Thrombectomy, Tissue Plasminogen Activator, Nomograms, Settore MED/26 - NEUROLOGIA, Neurology (clinical), Radiology, Cardiology and Cardiovascular Medicine, business, Fibrinolytic agent, Cohort study
Abstract

Background and Purpose— As a reliable scoring system to detect the risk of symptomatic intracerebral hemorrhage after thrombectomy for ischemic stroke is not yet available, we developed a nomogram for predicting symptomatic intracerebral hemorrhage in patients with large vessel occlusion in the anterior circulation who received bridging of thrombectomy with intravenous thrombolysis (training set), and to validate the model by using a cohort of patients treated with direct thrombectomy (test set). Methods— We conducted a cohort study on prospectively collected data from 3714 patients enrolled in the IER (Italian Registry of Endovascular Stroke Treatment in Acute Stroke). Symptomatic intracerebral hemorrhage was defined as any type of intracerebral hemorrhage with increase of ≥4 National Institutes of Health Stroke Scale score points from baseline ≤24 hours or death. Based on multivariate logistic models, the nomogram was generated. We assessed the discriminative performance by using the area under the receiver operating characteristic curve. Results— National Institutes of Health Stroke Scale score, onset-to-end procedure time, age, unsuccessful recanalization, and Careggi collateral score composed the IER-SICH nomogram. After removing Careggi collateral score from the first model, a second model including Alberta Stroke Program Early CT Score was developed. The area under the receiver operating characteristic curve of the IER-SICH nomogram was 0.778 in the training set (n=492) and 0.709 in the test set (n=399). The area under the receiver operating characteristic curve of the second model was 0.733 in the training set (n=988) and 0.685 in the test set (n=779). Conclusions— The IER-SICH nomogram is the first model developed and validated for predicting symptomatic intracerebral hemorrhage after thrombectomy. It may provide indications on early identification of patients for more or less postprocedural intensive management.

Published
2019

39. Endovascular Treatment of Spontaneous Intracranial Internal Carotid Dissection in a Young Patient Affected by Systemic Lupus Erythematosus: A Case Report

Author

Racchiusa, Sergio, Longo, Marcello, Bernava, Gianmarco, Pitrone, Antonio, Papa, Rosario, Granata, Francesca, Centorrino, Giuseppe, and Vinci, Sergio Lucio

Subjects
Internal carotid artery (ICA), immune system diseases, Dissection, Systemic lupus erythematosus (SLE), cardiovascular system, cardiovascular diseases, Systemic lupus erythematosus (SLE), Dissection, Internal carotid artery (ICA), skin and connective tissue diseases, Article
Abstract

Systemic lupus erythematosus (SLE) increases the risk of cerebrovascular events due to vascular changes, resulting in the weakening of the vessel walls. Moreover, patients with SLE have more incidence of arterial lesions such as dissections. Internal carotid dissection (ICA) is an infrequent cause of ischemic stroke, representing 2% of all ischemic events. We present a case of ischemic stroke, caused by a spontaneous dissection of intracranial ICA, treated with endovascular stent implantation, in a 22-year-old woman affected by SLE, newly diagnosed. ICA dissection with consequent ischemic stroke is an unusual first presentation of SLE disease. Our case highlights how, despite an infrequent occurrence, ICA dissection should be considered for young adults presenting with ischemic stroke, especially in those affected by SLE. This paper also shows the good technical result in the use of stenting in case of intracranial ICA dissection.

Published
2017

40. Posterior Fossa Arteriovenous Malformations: Experience with 14 Patients and a Systematic Review of the Literature.

Author

Corniola, Marco V., Meling, Torstein R., Bijlenga, Philippe, Bernava, Gianmarco, Machi, Paolo, and Schaller, Karl

Subjects
META-analysis, ARTERIOVENOUS malformation, INFRATENTORIAL brain tumors, CHRONIC pancreatitis, CRANIAL nerves, ALCOHOLISM
Abstract

Background The optimal management of posterior fossa arteriovenous malformations (pfAVMs) is a matter of debate. To advance this discussion, we present our clinical series and the results of a systematic literature review according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Methods Fourteen consecutive patients with pfAVMs were admitted between 2007 and 2018. Preoperative status, radiologic parameters, and outcome were assessed. A systematic literature review was performed according to the PRISMA-P guidelines. Results Ten patients presented with rupture (71%), of whom three had associated aneurysms (AAs). The treatments were microsurgery (n = 4), endovascular (n = 3), radiosurgery (n = 2), a combination of two or three treatment modalities (n = 3), or conservative (n = 2). At discharge, all four patients (100%) with unruptured pfAVMs had a good outcome (modified Rankin Scale [mRS]: 0–2). In contrast, in ruptured pfAVM cases, mRS was 0 to 2 in four patients (40%), mRS 3 to 4 in two (20%), mRS 5 in three (30%), and one patient (10%) died within 30 days after gamma knife treatment due to pancreatitis secondary to chronic alcohol abuse. At discharge, four patients (29%) had persistent preinterventional cranial nerve and/or focal neurologic deficits. The literature review identified 63 articles with 1,753 pfAVM patients. Overall, 66% of pfAVMs presented with rupture, and AAs were found in 20% of the cases, which is higher than in supratentorial AVMs (stAVMs). Conclusions Because pfAVMs are associated with higher rates of hemorrhagic presentation, higher rates of morbidity and mortality when ruptured, and have a higher incidence of AAs compared with stAVMs, early curative treatment is recommended as soon as the diagnosis is established, regardless of rupture status. [ABSTRACT FROM AUTHOR]

Published
2020
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41. Direct thromboaspiration efficacy for mechanical thrombectomy is related to the angle of interaction between the aspiration catheter and the clot.

Author

Bernava, Gianmarco, Rosi, Andrea, Boto, José, Brina, Olivier, Kulcsar, Zsolt, Czarnetzki, Christoph, Carrera, Emmanuel, Schaller, Karl, Lovblad, Karl-Olof, and Machi, Paolo

Subjects
THROMBOSIS surgery, ARTERIAL occlusions, BLOOD circulation, CATHETERS, CEREBRAL ischemia, KINEMATICS, SURGICAL stents, THROMBOSIS, VEIN surgery, TREATMENT effectiveness, SALVAGE therapy, STROKE patients
Abstract

Background Direct thromboaspiration has been reported as an effective mechanical treatment for acute ischemic stroke. We aimed to determine whether the angle of interaction between the aspiration catheter and the clot affects the success of clot removal in ischemic stroke patients with large vessel occlusion in the anterior and posterior circulation. Methods All patients treated at our institution by direct thromboaspiration as a firstline technique between January 2016 and December 2017 were enrolled in the study. We retrospectively reviewed baseline and procedural characteristics, the angle of interaction formed between the aspiration catheter and the clot, the modified Thrombolysis in Cerebral Infarction score, and the 3 month modified Rankin Scale score. Results 85 patients underwent direct thromboaspiration as the firstline treatment during the study period. 100 direct thromboaspiration passes were performed. An angle of interaction of ≥125.5° significantly influenced the success of clot removal (P<0.001) with good sensitivity and specificity, in particular for occlusion of the middle cerebral and basilar artery. The combination of aspiration with a stent retriever based thrombectomy was a valid rescue treatment in cases of standalone direct thromboaspiration failure. Conclusions In our series, an angle of interaction between the aspiration catheter and the clot of ≥125.5° was significantly associated with successful clot removal. The prediction of the angle of interaction on pretreatment imaging may help operators to select the most adequate mechanical thrombectomy technique on a case by case basis. [ABSTRACT FROM AUTHOR]

Published
2020
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43. Experimental comparison of first-pass effect between direct thromboaspiration and combined thrombectomy in the setting of distal basilar occlusion

Author

Seiffert, Reza, Brina, Olivier, Reymond, Philippe, Hofmeister, Jeremy, Bernava, Gianmarco, Rosi, Andrea, Michels, Lars, Kulcsar, Zsolt, Lovblad, Karl-Olof, and Machi, Paolo

Abstract

Background Studies investigating endovascular therapy in vertebro-basilar stroke have led to controversial results in the past, but recent randomized trials seem to show an effectiveness superiority of endovascular therapy versus best medical treatment. However, uncertainty remains concerning many aspects of thrombectomy in acute basilar artery occlusion, notably technical considerations. This study compared the first-pass effect of direct thromboaspiration and combined thrombectomy in the setting of distal basilar occlusion.Methods An in-vitro experimental set-up was used, consisting of a vascular phantom model and thrombus analogs of different consistencies to mimic human clots. Thrombus analogs were injected into the model through the vertebral artery and flowed to the basilar distal third to mimic a distal basilar occlusion. Ten procedures were performed for each thrombus analog stiffness and technique (direct thromboaspiration versus combined thrombectomy).Results Direct thromboaspiration showed an overall first-pass effect rate of 83.3% (25/30) and was particularly effective for ultra-soft and soft clot analogs, but decreased for hard clot analogs. Combined thrombectomy had an overall first-pass effect rate of 56.7% (17/30). The effect rate for ultra-soft and soft clot analogs was 60% and 50% for hard clot analogs. In the softer clot analogs, the stent-retriever device used for the combined thrombectomies tended to deviate the clot analog from a co-axial trajectory with the aspiration catheter.Conclusions In the context of distal basilar occlusion, our in-vitro results showed that higher first-pass effect rates were achieved with direct thromboaspiration compared to combined thrombectomy in all types of thrombus analogs.

Published
2024
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44. Endovascular treatment strategies for simultaneous bilateral anterior circulation occlusions in acute ischemic stroke: A single-center experience and systematic review of the literature

Author

Bernava, Gianmarco, Botti, Paul, Rosi, Andrea, Hofmeister, Jeremy, Yilmaz, Hasan, Carrera, Emmanuel, Brina, Olivier, Reymond, Philippe, Muster, Michel, Kulcsar, Zsolt, Lovblad, Karl-Olof, and Machi, Paolo

Abstract

Background Bilateral and simultaneous occlusion of the anterior circulation is a rare event in patients with acute ischemic stroke. Although endovascular treatment is feasible and safe, the endovascular strategy to be used remains a subject of debate.Objective To assess the different endovascular strategies proposed for the treatment of a bilateral, simultaneous anterior circulation occlusion following acute ischemic stroke.Methods We present a retrospective study of the clinical and radiological records of all patients with a bilateral, simultaneous anterior circulation occlusion treated at our center between January 2019 and December 2022. Following the PRISMA guidelines, we also conducted a systematic review of the literature.Results Two patients with a bilateral and simultaneous middle cerebral artery occlusion were treated at our center during the study period. A TICI score ≥2b was obtained in 4 out of 4 occlusions. Modified Rankin Scale (mRS) at 90 days was 0 and 4, respectively. The literature review retrieved reports on 22 patients. The most frequent bilateral occlusion sites were internal carotid artery-middle cerebral artery. The clinical presentation was severe in most patients. A combined thrombectomy technique proved to have the highest number of first-pass recanalization. A TICI ≥2b was obtained in 95% of patients and an mRS ≤2 was found in 31.8% of patients.Conclusions In patients with bilateral and simultaneous occlusion of the anterior circulation, endovascular treatment using a combined technique appears to be rapid and effective. The clinical evolution of this patient population strongly depends on the severity of the onset symptoms.

Published
2024
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45. Three-dimensional rotational angiography improves mechanical thrombectomy recanalization rate for acute ischaemic stroke due to middle cerebral artery M2 segment occlusions

Author

Rosi, Andrea, Bernava, Gianmarco, Hofmeister, Jeremy, Nicolò, Madruzzato, Boto, José, Yilmaz, Hasan, Reymond, Philippe, Brina, Olivier, Muster, Michel, Carrera, Emmanuel, Lövblad, Karl-Olof, and Machi, Paolo

Abstract

Background Occlusions of the middle cerebral artery (MCA) M2 segments can be difficult to address with mechanical thrombectomy (MTB) using standard projections and this can affect the final recanalization. Three-dimensional rotational angiography (3D-RA) allows to obtain a 3D model of cerebral vessels in a few seconds and to determine the best two-dimensional (2D) projections to be selected to evaluate and treat cerebrovascular diseases, such as aneurysms or vascular malformations. We aimed to determine if 3D-RA could be applied also in MTB.Methods A retrospective review of two patient cohorts treated during two time periods of 12 months before and after the introduction of 3D-RA use at our institution for MTB in M2 occlusions. Analyses were conducted to compare the two groups for procedural characteristics, such as timing, recanalization rate and complications and clinical outcome.Results One hundred acute ischaemic stroke (AIS) patients (3D-RA group = 57; controls = 43) underwent MTB for an M2 occlusion during the two study periods. Recanalization rates were significantly higher in cases treated with 3D-RA. The mean 3D technique thrombectomy time was compared to that of non-3D cases (47 vs. 49 min, respectively).Conclusions Our findings showed that 3D-RA is a useful tool to select specific working projections to AIS patients presenting an M2 occlusion by improving final recanalization compared to standard projections, without increasing the overall procedural time.

Published
2024
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46. Benchtop evaluation of a double stent retriever thrombectomy technique for acute ischemic stroke treatment

Author

Hofmeister, Jeremy, Bernava, Gianmarco, Rosi, Andrea, Reymond, Philippe, Brina, Olivier, Muster, Michel, Lovblad, Karl-Olof, and Machi, Paolo

Abstract

Background and purpose A mechanical thrombectomy technique using a double stent retriever approach has been reported for the treatment of patients with acute ischemic stroke. The purpose of this study was to perform a benchtop evaluation of the mechanism of action and efficacy of a double-stent retriever approach compared to a single-stent retriever approach.Materials and methods In vitro, mechanical thrombectomy procedures were performed in a vascular phantom reproducing an M1-M2 occlusion with two different clot analog consistencies (soft and hard). We compared the double stent retriever approach to the single stent retriever approach and recorded the recanalization rate, distal embolization, and retrieval forces of each mechanical thrombectomy procedure.Results The double stent retriever approach achieved a higher recanalization rate and lower embolic complications compared to the single stent retriever approach. This seems to stem from two facts: the greater probability of targeting the correct artery with two stents in the case of bifurcation occlusion, and an improved clot capture mechanism using the double stent retriever approach. However, the double stent retriever was associated with an increased initial retrieval force.Conclusions In vitro evaluation of the mechanism of action of the double stent retriever provided explanations that appear to support the high efficacy of such an approach in patient cohorts and could help operators when selecting the optimal mechanical thrombectomy strategy in cases of arterial occlusions difficult to treat with a single stent retriever.

Published
2024
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47. Effectiveness of the preventive administration of vasoactive amines in counterbalancing significant patient blood pressure drops following nimodipine administration during mechanical thrombectomy procedures

Author

Bernava, Gianmarco, Tesoro, Rosa, Boto, José, Challita, Myriam, Rosi, Andrea, Hofmeister, Jeremy, Yilmaz, Hasan, Carrera, Emmanuel, Brina, Olivier, Reymond, Philippe, Muster, Michel, Kulcsar, Zsolt, Lovblad, Karl-Olof, and Machi, Paolo

Abstract

Background Focal vasospasm (FV) of the occluded vessel can occur during the endovascular treatment of acute ischemic stroke (AIS). Nimodipine is commonly used to treat vasospasm and can play a role in distinguishing it from artery narrowing due to iatrogenic dissection or residual clot. However, nimodipine administration can result in arterial hypotension and subsequent enlargement of the ischemic core.Objective To assess the efficacy of preventive and continuous vasoactive amine infusion to counterbalance nimodipine-induced hypotension.Methods We reviewed data from a prospective registry of patients treated for AIS between January 2019 and January 2022 who were administered nimodipine. All patients were equipped with an arterial cannula for invasive blood pressure measurement and given vasoactive amines preemptively before general anesthesia and throughout the procedure. Data obtained from invasive monitoring of mean arterial blood pressure (MABP) in a time-lapse of 25 min before and after nimodipine administration were analyzed.Results MABP significantly decreased after nimodipine administration but remained within the recommended range (81.79 ± 0.49 mmHg). Nimodipine was effective in reducing FV caused by stent retriever passage in 76.3% of cases. Furthermore, it proved valuable in diagnosing iatrogenic dissection (9.2%), residual clot (10.5%), or intracranial stenosis (4%).Conclusions Infusion of vasoactive amines effectively counteracted the intraarterial nimodipine effect, thus avoiding frank arterial hypotension during endovascular treatment. Nimodipine has been useful in differentiating the diagnosis of FV resulting from mechanical thrombectomy and other potential causes, such as iatrogenic dissection or residual clot.

Published
2024
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48. Benchtop evaluation of a double stent retriever thrombectomy technique for acute ischemic stroke treatment.

Author

Hofmeister, Jeremy, Bernava, Gianmarco, Rosi, Andrea, Reymond, Philippe, Brina, Olivier, Muster, Michel, Lovblad, Karl-Olof, and Machi, Paolo

Abstract

A mechanical thrombectomy technique using a double stent retriever approach has been reported for the treatment of patients with acute ischemic stroke. The purpose of this study was to perform a benchtop evaluation of the mechanism of action and efficacy of a double-stent retriever approach compared to a single-stent retriever approach.In vitro, mechanical thrombectomy procedures were performed in a vascular phantom reproducing an M1-M2 occlusion with two different clot analog consistencies (soft and hard). We compared the double stent retriever approach to the single stent retriever approach and recorded the recanalization rate, distal embolization, and retrieval forces of each mechanical thrombectomy procedure.The double stent retriever approach achieved a higher recanalization rate and lower embolic complications compared to the single stent retriever approach. This seems to stem from two facts: the greater probability of targeting the correct artery with two stents in the case of bifurcation occlusion, and an improved clot capture mechanism using the double stent retriever approach. However, the double stent retriever was associated with an increased initial retrieval force.In vitro evaluation of the mechanism of action of the double stent retriever provided explanations that appear to support the high efficacy of such an approach in patient cohorts and could help operators when selecting the optimal mechanical thrombectomy strategy in cases of arterial occlusions difficult to treat with a single stent retriever. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Acute Stenting and Concomitant Tirofiban Administration for the Endovascular Treatment of Acute Ischemic Stroke Related to Intracranial Artery Dissections: A Single Center Experience and Systematic Review of the Literature

Author

Olivier Brina, Marco Vincenzo Corniola, Karl-Olof Lövblad, Zsolt Kulcsar, Hasan Yilmaz, Torstein R. Meling, Jeremy Hofmeister, Emmanuel Carrera, Gianmarco Bernava, M. Muster, Andrea Rosi, Philippe Reymond, Paolo Machi, University of Zurich, and Bernava, Gianmarco

Subjects
Male, Time Factors, Endovascular Procedures/adverse effects/instrumentation, medicine.medical_treatment, Intracranial Aneurysm/complications/diagnostic imaging/physiopathology/therapy, 0302 clinical medicine, Ischemic Stroke/diagnostic imaging/etiology/physiopathology/therapy, Stroke, Interventional neuroradiology, Rehabilitation, Endovascular Procedures, Intracranial Artery, Tirofiban, Middle Aged, Tirofiban/administration & dosage/adverse effects, 3. Good health, 2746 Surgery, Dissection, 2728 Neurology (clinical), Treatment Outcome, Administration, Intravenous, Female, Stents, Cardiology and Cardiovascular Medicine, medicine.drug, Adult, medicine.medical_specialty, Platelet Aggregation Inhibitors/administration & dosage/adverse effects, 610 Medicine & health, Revascularization, ddc:616.0757, 2705 Cardiology and Cardiovascular Medicine, 03 medical and health sciences, Young Adult, 10043 Clinic for Neuroradiology, medicine, Humans, cardiovascular diseases, Vascular Patency, Aged, Ischemic Stroke, Retrospective Studies, business.industry, Aneurysm, Dissecting/complications/diagnostic imaging/physiopathology/therapy, Stent, Intracranial Aneurysm, medicine.disease, ddc:616.8, Surgery, 2742 Rehabilitation, Aortic Dissection, Concomitant, Neurology (clinical), business, 030217 neurology & neurosurgery, Platelet Aggregation Inhibitors
Abstract

Background Intracranial artery dissection is an uncommon cause of acute ischemic stroke. Although acute stenting of the dissected arterial segment is a therapeutic option, the associated antiplatelet regimen remains a matter of debate. Objectives To evaluate the efficacy and safety of acute intracranial stenting together with concomitant intravenous administration of tirofiban and to perform a systematic review of the literature. Materials and methods A single-center, retrospective study of the clinical and radiological records of all patients treated at our center by intracranial stenting in the setting of acute ischemic stroke between January 2010 and December 2020. A systematic review of the literature was conducted according to the PRISMA-P guidelines for relevant publications from January 1976 to December 2020 on intracranial artery dissection treated by stent. Results Seven patients with intracranial artery dissections underwent acute stenting with concomitant tirofiban during the study period. Mid-term follow-up showed parent artery patency in 6/7 cases (85.7%). The modified Rankin Score was ≤ 0-2 at 3 months in 5/7 cases (71.4%). The literature review identified 22 patients with intracranial artery dissection treated with acute stenting in association with different antithrombotic therapies. Complete revascularization was obtained in 86.3% of cases with a modified Rankin Score of ≤ 0-2 in 68% of patients at 3-month follow-up. Conclusions Acute intracranial stenting together with intravenous tirofiban administration could be a therapeutic option in patients with intracranial artery dissection and a small ischemic core.

Published
2020

50. MRI patient selection for endovascular thrombectomy in acute ischemic stroke: correlation between pretreatment diffusion weighted imaging and outcome scores

Author

Agostino Tessitore, Alessandro Calamuneri, Marcello Longo, Sergio Vinci, Federica Vernuccio, Rosa Musolino, Giuseppe Centorrino, Antonio Armando Caragliano, Enricomaria Mormina, Federico Midiri, Francesca Granata, Rosario Papa, Gianmarco Bernava, Antonio Pitrone, Longo, Marcello, Bernava, Gianmarco, Calamuneri, Alessandro, Caragliano, Antonio A., Pitrone, Antonio, Papa, Rosario, Mormina, Enricomaria, Granata, Francesca, Musolino, Rosa, Tessitore, Agostino, Centorrino, Giuseppe, Midiri, Federico, Vernuccio, Federica, and Vinci, Sergio L.

Subjects
Male, medicine.medical_specialty, Radiology, Nuclear Medicine and Imaging, medicine.medical_treatment, Diffusion weighted imaging, Magnetic resonance, Revascularization, Stroke, Aged, Brain Ischemia, Diffusion Magnetic Resonance Imaging, Endovascular Procedures, Female, Humans, Thrombectomy, Tomography, X-Ray Computed, Treatment Outcome, Patient Selection, 03 medical and health sciences, 0302 clinical medicine, medicine, 030212 general & internal medicine, Neuroradiology, medicine.diagnostic_test, business.industry, Cerebral infarction, Interventional radiology, Magnetic resonance imaging, General Medicine, Thrombolysis, medicine.disease, Collateral circulation, Radiology, business, 030217 neurology & neurosurgery
Abstract

Introduction: Eligibility for endovascular treatment (EVT) in patients with acute ischemic stroke (AIS) depends, amongst other factors, on CT- or MR-based scores. The aim of this study was to investigate the role of Alberta Stroke Program Early CT score based on diffusion weighted imaging (MR-ASPECT) in the assessment of brain damage pre-EVT, patient selection for EVT and outcome. Materials and methods: We included in this study patients with National Institute of Health stroke score (NIHSS) at admission ≥ 8, MR-ASPECT ≥ 5 and anterior AIS, who were treated with EVT in our hospital. All patients were clinically evaluated at admission, post-EVT, discharge and at 3-month follow-up. We used MR-ASPECT to establish infarct core extension at admission. We evaluated ASPECT score at admission (CT-ASPECT-IN), 24 h after EVT and at discharge, NIHSS, modified Ranking Scale (mRS), Thrombolysis in Cerebral Infarction scale (TICI), onset-to-intervention-delay (OTID) and Collateral Circulation Score (CCS). Results: 68 patients (mean age 78 ± 11.9 years) were included in this study. 54.4 and 64.7% of patients had strong clinical improvement after 24 h from EVT and at discharge, respectively. NIHSS evaluated 24 h after EVT correlated with CCS, TICI and OTID. We observed a favourable outcome (mRS 0–2) in 52.9% of patients at 3-month follow-up. MR-ASPECT score correlated with post-EVT outcome better than CT-ASPECT-IN scores. Conclusion: MR-ASPECT score based on diffusion weighted imaging is useful for the selection of patients with AIS that can have a favourable outcome from EVT. A prompt EVT has huge impact on patient outcome.

Published
2018

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