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1. Brain-based classification of youth with anxiety disorders: transdiagnostic examinations within the ENIGMA-Anxiety database using machine learning

Author

Bruin, Willem B., Zhutovsky, Paul, van Wingen, Guido A., Bas-Hoogendam, Janna Marie, Groenewold, Nynke A., Hilbert, Kevin, Winkler, Anderson M., Zugman, Andre, Agosta, Federica, Åhs, Fredrik, Andreescu, Carmen, Antonacci, Chase, Asami, Takeshi, Assaf, Michal, Barber, Jacques P., Bauer, Jochen, Bavdekar, Shreya Y., Beesdo-Baum, Katja, Benedetti, Francesco, Bernstein, Rachel, Björkstrand, Johannes, Blair, Robert J., Blair, Karina S., Blanco-Hinojo, Laura, Böhnlein, Joscha, Brambilla, Paolo, Bressan, Rodrigo A., Breuer, Fabian, Cano, Marta, Canu, Elisa, Cardinale, Elise M., Cardoner, Narcís, Cividini, Camilla, Cremers, Henk, Dannlowski, Udo, Diefenbach, Gretchen J., Domschke, Katharina, Doruyter, Alexander G. G., Dresler, Thomas, Erhardt, Angelika, Filippi, Massimo, Fonzo, Gregory A., Freitag, Gabrielle F., Furmark, Tomas, Ge, Tian, Gerber, Andrew J., Gosnell, Savannah N., Grabe, Hans J., Grotegerd, Dominik, Gur, Ruben C., Gur, Raquel E., Hamm, Alfons O., Han, Laura K. M., Harper, Jennifer C., Harrewijn, Anita, Heeren, Alexandre, Hofmann, David, Jackowski, Andrea P., Jahanshad, Neda, Jett, Laura, Kaczkurkin, Antonia N., Khosravi, Parmis, Kingsley, Ellen N., Kircher, Tilo, Kostic, Milutin, Larsen, Bart, Lee, Sang-Hyuk, Leehr, Elisabeth J., Leibenluft, Ellen, Lochner, Christine, Lui, Su, Maggioni, Eleonora, Manfro, Gisele G., Månsson, Kristoffer N. T., Marino, Claire E., Meeten, Frances, Milrod, Barbara, Jovanovic, Ana Munjiza, Mwangi, Benson, Myers, Michael J., Neufang, Susanne, Nielsen, Jared A., Ohrmann, Patricia A., Ottaviani, Cristina, Paulus, Martin P., Perino, Michael T., Phan, K. Luan, Poletti, Sara, Porta-Casteràs, Daniel, Pujol, Jesus, Reinecke, Andrea, Ringlein, Grace V., Rjabtsenkov, Pavel, Roelofs, Karin, Salas, Ramiro, Salum, Giovanni A., Satterthwaite, Theodore D., Schrammen, Elisabeth, Sindermann, Lisa, Smoller, Jordan W., Soares, Jair C., Stark, Rudolf, Stein, Frederike, Straube, Thomas, Straube, Benjamin, Strawn, Jeffrey R., Suarez-Jimenez, Benjamin, Sylvester, Chad M., Talati, Ardesheer, Thomopoulos, Sophia I., Tükel, Raşit, van Nieuwenhuizen, Helena, Werwath, Kathryn, Wittfeld, Katharina, Wright, Barry, Wu, Mon-Ju, Yang, Yunbo, Zilverstand, Anna, Zwanzger, Peter, Blackford, Jennifer U., Avery, Suzanne N., Clauss, Jacqueline A., Lueken, Ulrike, Thompson, Paul M., Pine, Daniel S., Stein, Dan J., van der Wee, Nic J. A., Veltman, Dick J., and Aghajani, Moji

Published
2024
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6. Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group

Author

Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Amod, Alyssa R., Laansma, Max A., Van Velzen, Laura S., Aghajani, Moji, Hilbert, Kevin, Oh, Hyuntaek, Salas, Ramiro, Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Blair, James R., Blair, Karina S., Hirsch, Joy, Pantazatos, Spiro P., Schneier, Franklin R., Talati, Ardesheer, Roelofs, Karin, Volman, Inge, Blanco-Hinojo, Laura, Cardoner, Narcís, Pujol, Jesus, Beesdo-Baum, Katja, Ching, Christopher R. K., Thomopoulos, Sophia I., Jansen, Andreas, Kircher, Tilo, Krug, Axel, Nenadić, Igor, Stein, Frederike, Dannlowski, Udo, Grotegerd, Dominik, Lemke, Hannah, Meinert, Susanne, Winter, Alexandra, Erb, Michael, Kreifelts, Benjamin, Gong, Qiyong, Lui, Su, Zhu, Fei, Mwangi, Benson, Soares, Jair C., Wu, Mon-Ju, Bayram, Ali, Canli, Mesut, Tükel, Raşit, Westenberg, P. Michiel, Heeren, Alexandre, Cremers, Henk R., Hofmann, David, Straube, Thomas, Doruyter, Alexander G. G., Lochner, Christine, Peterburs, Jutta, Van Tol, Marie-José, Gur, Raquel E., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Filippi, Courtney A., Gold, Andrea L., Harrewijn, Anita, Zugman, André, Bülow, Robin, Grabe, Hans J., Völzke, Henry, Wittfeld, Katharina, Böhnlein, Joscha, Dohm, Katharina, Kugel, Harald, Schrammen, Elisabeth, Zwanzger, Peter, Leehr, Elisabeth J., Sindermann, Lisa, Ball, Tali M., Fonzo, Gregory A., Paulus, Martin P., Simmons, Alan, Stein, Murray B., Klumpp, Heide, Phan, K. Luan, Furmark, Tomas, Månsson, Kristoffer N. T., Manzouri, Amirhossein, Avery, Suzanne N., Blackford, Jennifer Urbano, Clauss, Jacqueline A., Feola, Brandee, Harper, Jennifer C., Sylvester, Chad M., Lueken, Ulrike, Veltman, Dick J., Winkler, Anderson M., Jahanshad, Neda, Pine, Daniel S., Thompson, Paul M., Stein, Dan J., and Van der Wee, Nic J. A.

Published
2023
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9. Correction: Neural correlates of automatic emotion regulation and their association with suicidal ideation in adolescents during the first 90-days of residential care

Author

Dobbertin, Matthew, primary, Blair, Karina S., additional, Aloi, Joseph, additional, Bajaj, Sahil, additional, Bashford-Largo, Johannah, additional, Mathur, Avantika, additional, Zhang, Ru, additional, Carollo, Erin, additional, Schwartz, Amanda, additional, Elowsky, Jaimie, additional, Ringle, J. L., additional, Tyler, Patrick, additional, and Blair, R. James, additional

Published
2024
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10. Neural correlates of automatic emotion regulation and their association with suicidal ideation in adolescents during the first 90-days of residential care

Author

Dobbertin, Matthew, primary, Blair, Karina S., additional, Aloi, Joseph, additional, Bajaj, Sahil, additional, Bashford-Largo, Johannah, additional, Mathur, Avantika, additional, Zhang, Ru, additional, Carollo, Erin, additional, Schwartz, Amanda, additional, Elowsky, Jaimie, additional, Ringle, J. L., additional, Tyler, Patrick, additional, and Blair, R. James, additional

Published
2024
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14. Cortical and subcortical brain structure in generalized anxiety disorder: findings from 28 research sites in the ENIGMA-Anxiety Working Group

Author

Harrewijn, Anita, Cardinale, Elise M., Groenewold, Nynke A., Bas-Hoogendam, Janna Marie, Aghajani, Moji, Hilbert, Kevin, Cardoner, Narcis, Porta-Casteràs, Daniel, Gosnell, Savannah, Salas, Ramiro, Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Blair, Karina S., Blair, James R., Hammoud, Mira Z., Milad, Mohammed R., Burkhouse, Katie L., Phan, K. Luan, Schroeder, Heidi K., Strawn, Jeffrey R., Beesdo-Baum, Katja, Jahanshad, Neda, Thomopoulos, Sophia I., Buckner, Randy, Nielsen, Jared A., Smoller, Jordan W., Soares, Jair C., Mwangi, Benson, Wu, Mon-Ju, Zunta-Soares, Giovana B., Assaf, Michal, Diefenbach, Gretchen J., Brambilla, Paolo, Maggioni, Eleonora, Hofmann, David, Straube, Thomas, Andreescu, Carmen, Berta, Rachel, Tamburo, Erica, Price, Rebecca B., Manfro, Gisele G., Agosta, Federica, Canu, Elisa, Cividini, Camilla, Filippi, Massimo, Kostić, Milutin, Munjiza Jovanovic, Ana, Alberton, Bianca A. V., Benson, Brenda, Freitag, Gabrielle F., Filippi, Courtney A., Gold, Andrea L., Leibenluft, Ellen, Ringlein, Grace V., Werwath, Kathryn E., Zwiebel, Hannah, Zugman, André, Grabe, Hans J., Van der Auwera, Sandra, Wittfeld, Katharina, Völzke, Henry, Bülow, Robin, Balderston, Nicholas L., Ernst, Monique, Grillon, Christian, Mujica-Parodi, Lilianne R., van Nieuwenhuizen, Helena, Critchley, Hugo D., Makovac, Elena, Mancini, Matteo, Meeten, Frances, Ottaviani, Cristina, Ball, Tali M., Fonzo, Gregory A., Paulus, Martin P., Stein, Murray B., Gur, Raquel E., Gur, Ruben C., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Harper, Jennifer, Myers, Michael, Perino, Michael T., Sylvester, Chad M., Yu, Qiongru, Lueken, Ulrike, Veltman, Dick J., Thompson, Paul M., Stein, Dan J., Van der Wee, Nic J. A., Winkler, Anderson M., and Pine, Daniel S.

Published
2021
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18. Latent profiles of substance use, early life stress, and attention/externalizing problems and their association with neural correlates of reinforcement learning in adolescents

Author

Crum, Kathleen I., primary, Aloi, Joseph, additional, Blair, Karina S., additional, Bashford-Largo, Johannah, additional, Bajaj, Sahil, additional, Zhang, Ru, additional, Hwang, Soonjo, additional, Schwartz, Amanda, additional, Elowsky, Jaimie, additional, Filbey, Francesca M., additional, Dobbertin, Matthew, additional, and Blair, R. James, additional

Published
2023
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22. Brain-Based Classification of Youth with Anxiety Disorders: an ENIGMA-ANXIETY Transdiagnostic Examination using Machine Learning

Author

Bruin, Willem B., primary, Zhutovsky, Paul, additional, van Wingen, Guido, additional, Bas-Hoogendam, Janna Marie, additional, Groenewold, Nynke A., additional, Hilbert, Kevin, additional, Winkler, Anderson M., additional, Zugman, André, additional, Agosta, Federica, additional, Åhs, Fredrik, additional, Andreescu, Carmen, additional, Antonacci, Chase, additional, Asami, Takeshi, additional, Assaf, Michal, additional, Barber, Jacques, additional, Bauer, Jochen, additional, Bavdekar, Shreya, additional, Beesdo-Baum, Katja, additional, Benedetti, Francesco, additional, Bernstein, Rachel, additional, Björkstrand, Johannes, additional, Blair, Robert, additional, Blair, Karina S., additional, Blanco-Hinojo, Laura, additional, Böhnlein, Joscha, additional, Brambilla, Paolo, additional, Bressan, Rodrigo, additional, Breuer, Fabian, additional, Cano, Marta, additional, Canu, Elisa, additional, Cardinale, Elise M, additional, Cardoner, Narcís, additional, Cividini, Camilla, additional, Cremers, Henk, additional, Dannlowski, Udo, additional, Diefenbach, Gretchen J., additional, Domschke, Katharina, additional, Doruyter, Alexander, additional, Dresler, Thomas, additional, Erhardt, Angelika, additional, Filippi, Massimo, additional, Fonzo, Gregory, additional, Freitag, Gabrielle Felice, additional, Furmark, Tomas, additional, Ge, Tian, additional, Gerber, Andrew J., additional, Gosnell, Savannah, additional, Grabe, Hans J., additional, Grotegerd, Dominik, additional, Gur, Ruben C., additional, Gur, Raquel E., additional, Hamm, Alfons O., additional, Han, Laura K. M., additional, Harper, Jennifer, additional, Harrewijn, Anita, additional, Heeren, Alexandre, additional, Hoffman, David, additional, Jackowski, Andrea P., additional, Jahanshad, Neda, additional, Jett, Laura, additional, Kaczkurkin, Antonia N., additional, Khosravi, Parmis, additional, Kingsley, Ellen, additional, Kircher, Tilo, additional, Kostić, Milutin, additional, Larsen, Bart, additional, Lee, Sang-Hyuk, additional, Leehr, Elisabeth, additional, Leibenluft, Ellen, additional, Lochner, Christine, additional, Lui, Su, additional, Maggioni, Eleonora, additional, Manfro, Gisele Gus, additional, Månsson, Kristoffer, additional, Marino, Claire, additional, Meeten, Frances, additional, Milrod, Barbara, additional, Munjiza, Ana, additional, Irungu, Benson, additional, Myers, Michael, additional, Neufang, Susanne, additional, Nielsen, Jared, additional, Ohrmann, Patricia, additional, Ottaviani, Cristina, additional, Paulus, Martin P, additional, Perino, Michael T., additional, Phan, K Luan, additional, Poletti, Sara, additional, Porta-Casteràs, Daniel, additional, Pujol, Jesus, additional, Reinecke, Andrea, additional, Ringlein, Grace, additional, Rjabtsenkov, Pavel, additional, Roelofs, Karin, additional, Salas, Ramiro, additional, Salum, Giovanni, additional, Satterthwaite, Theodore D., additional, Schrammen, Elisabeth, additional, Sindermann, Lisa, additional, Smoller, Jordan, additional, Soares, Jair, additional, Stark, Rudolf, additional, Stein, Frederike, additional, straube, thomas, additional, Straube, Benjamin, additional, Strawn, Jeffrey, additional, Suarez-Jimenez, Benjamin, additional, Sylvester, Chad M., additional, Talati, Ardesheer, additional, Thomopoulos, Sophia I, additional, Tükel, Raşit, additional, van Nieuwenhuizen, Helena, additional, Werwath, Katy E., additional, Wittfeld, Katharina, additional, Wright, Barry, additional, Wu, Mon-Ju, additional, Yang, Yunbo, additional, Zilverstand, Anna, additional, Zwanzger, Peter, additional, Blackford, Jennifer, additional, Avery, Suzanne, additional, Clauss, Jacqueline, additional, Lueken, Ulrike, additional, Thompson, Paul, additional, Pine, Daniel, additional, Stein, Dan J., additional, van der Wee, Nic, additional, Veltman, Dick, additional, and Aghajani, Moji, additional

Published
2022
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23. Impact of Sleep Quality on the Association Between Unease and Physical Exercise During Initial Stages of COVID-19 Pandemic in India

Author

Bajaj, Sahil, Blair, Karina S, Zhang, Ru, Bashford-Largo, Johannah, Dobbertin, Matthew, and Blair, R James

Subjects
Nature and Science of Sleep, Research Letter
Abstract

Sahil Bajaj,1,2 Karina S Blair,1,2 Ru Zhang,1,2 Johannah Bashford-Largo,1,2 Matthew Dobbertin,1,2 R James Blair1,2 1Multimodal Clinical Neuroimaging Laboratory (MCNL), Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, USA; 2Program for Trauma and Anxiety (PTAC), Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, USACorrespondence: Sahil BajajCenter for Neurobehavioral Research, Boys Town National Research Hospital, 14015 Flanagan Blvd. Suite #102, Boys Town, NE, USAEmail sahil.bajaj@boystown.org

Published
2020

25. Different forms of childhood maltreatment have different impacts on the neural systems involved in the representation of reinforcement value

Author

Blair, Karina S., primary, Aloi, Joseph, additional, Bashford-Largo, Johannah, additional, Zhang, Ru, additional, Elowsky, Jaimie, additional, Lukoff, Jennie, additional, Vogel, Steven, additional, Carollo, Erin, additional, Schwartz, Amanda, additional, Pope, Kayla, additional, Bajaj, Sahil, additional, Tottenham, Nim, additional, Dobbertin, Matthew, additional, and Blair, R. James, additional

Published
2022
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27. Alcohol and Cannabis Use Disorder Symptom Severity, Conduct Disorder, and Callous-Unemotional Traits and Impairment in Expression Recognition

Author

Blair, Robert James R., primary, Bashford-Largo, Johannah, additional, Zhang, Ru, additional, Mathur, Avantika, additional, Schwartz, Amanda, additional, Elowsky, Jaimie, additional, Tyler, Patrick, additional, Hammond, Christopher J., additional, Filbey, Francesca M., additional, Dobbertin, Matthew, additional, Bajaj, Sahil, additional, and Blair, Karina S., additional

Published
2021
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30. Individual associations of adolescent alcohol use disorder versus cannabis use disorder symptoms in neural prediction error signaling and the response to novelty

Author

Aloi, Joseph, primary, Crum, Kathleen I., additional, Blair, Karina S., additional, Zhang, Ru, additional, Bashford-Largo, Johannah, additional, Bajaj, Sahil, additional, Schwartz, Amanda, additional, Carollo, Erin, additional, Hwang, Soonjo, additional, Leiker, Emily, additional, Filbey, Francesca M., additional, Averbeck, Bruno B., additional, Dobbertin, Matthew, additional, and Blair, R. James R., additional

Published
2021
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31. Threat‐of‐shock decreases emotional interference on affective stroop performance in healthy controls and anxiety patients.

Author

Lago, Tiffany R., Blair, Karina S., Alvarez, Gabriella, Thongdarong, Amanda, Blair, James R., Ernst, Monique, and Grillon, Christian

Subjects
*AFFECT (Psychology), *ANXIETY, *EMOTIONAL conditioning, *ATTENTION control, *COGNITIVE interference
Abstract

Patients with anxiety disorders suffer from impaired concentration, potentially as a result of stronger emotional interference on attention. Studies using behavioural measures provide conflicting support for this hypothesis. Elevated state anxiety may be necessary to reliably document differences in emotional interference in patients versus healthy controls. The present study examines the effect of experimentally induced state anxiety (threat‐of‐shock) on attention interference by emotional stimuli. Anxiety patients (n = 36) and healthy controls (n = 32) completed a modified affective Stroop task during periods of safety and threat‐of‐shock. Results indicated that in both patients and controls, threat decreased negative, but not positive or neutral, emotional interference on attention (both p <.001). This finding supports a threat‐related narrowing of attention whereby a certain level of anxiety decreases task‐irrelevant processing. [ABSTRACT FROM AUTHOR]

Published
2022
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33. methods in : The experience of the generalized anxiety disorder working group

Author

Zugman, André, Harrewijn, Anita, Cardinale, Elise M., Zwiebel, Hannah, Freitag, Gabrielle F., Werwath, Katy E., Bas-Hoogendam, Janna M., Groenewold, Nynke A., Aghajani, Moji, Hilbert, Kevin, Cardoner, N. (Narcís), Porta-Casteràs, Daniel, Gosnell, Savannah, Salas, Ramiro, Blair, Karina S., Blair, James R., Hammoud, Mira Z., Milad, Mohammed, Burkhouse, Katie, Phan, K. Luan, Schroeder, Heidi K., Strawn, Jeffrey R., Beesdo-Baum, Katja, Thomopoulos, Sophia I., Grabe, Hans J., Van der Auwera, Sandra, Wittfeld, Katharina, Nielsen, Jared A., Buckner, Randy, Smoller, Jordan W., Mwangi, Benson, Soares, Jair C., Wu, Mon-Ju, Zunta-Soares, Giovana B., Jackowski, Andrea P., Pan, Pedro M., Salum, Giovanni A., Assaf, Michal, Diefenbach, Gretchen J., Brambilla, Paolo, Maggioni, Eleonora, Hofmann, David, Straube, Thomas, Andreescu, Carmen, Berta, Rachel, Tamburo, Erica, Price, Rebecca, Manfro, Gisele G., Critchley, Hugo D., Makovac, Elena, Mancini, Matteo, Meeten, Frances, Ottaviani, Cristina, Agosta, Federica, Canu, Elisa, Cividini, Camilla, Filippi, Massimo, Kostić, Milutin, Munjiza, Ana, Filippi, Courtney A., Leibenluft, Ellen, Alberton, Bianca A. V., Balderston, Nicholas L., Ernst, Monique, Grillon, Christian, Mujica-Parodi, Lilianne R., van Nieuwenhuizen, Helena, Fonzo, Gregory A., Paulus, Martin P., Stein, Murray B., Gur, Raquel E., Gur, Ruben C., Kaczkurkin, Antonia N., Larsen, Bart, Satterthwaite, Theodore D., Harper, Jennifer, Myers, Michael, Perino, Michael T., Yu, Qiongru, Sylvester, Chad M., Veltman, Dick J., Lueken, Ulrike, Van der Wee, Nic J. A., Stein, Dan J., Jahanshad, Neda, Thompson, Paul M., Pine, Daniel S., Winkler, Anderson M., and Universitat Autònoma de Barcelona

Subjects
Generalized anxiety disorder, Meta-analyses, Data sharing, Neuroimaging, Mega-analyses
Abstract

The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega-analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between-country transfer of subject-level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as the approach taken to implement them. The goal is to document the approach and help guide other research groups working with large brain imaging data sets as they develop their own analytic pipelines for mega-analyses. This report summarizes the background information and rationale for the various methodological decisions made by the ENIGMA-GAD group. The aim of this work is to help guide other research groups working with large brain imaging data sets

Published
2020

39. Mega‐analysis methods in ENIGMA: The experience of the generalized anxiety disorder working group.

Author

Zugman, André, Harrewijn, Anita, Cardinale, Elise M., Zwiebel, Hannah, Freitag, Gabrielle F., Werwath, Katy E., Bas‐Hoogendam, Janna M., Groenewold, Nynke A., Aghajani, Moji, Hilbert, Kevin, Cardoner, Narcis, Porta‐Casteràs, Daniel, Gosnell, Savannah, Salas, Ramiro, Blair, Karina S., Blair, James R., Hammoud, Mira Z., Milad, Mohammed, Burkhouse, Katie, and Phan, K. Luan

Subjects
ANXIETY disorders, GENERALIZED anxiety disorder, BRAIN imaging, CURIOSITIES & wonders, QUALITY control
Abstract

The ENIGMA group on Generalized Anxiety Disorder (ENIGMA‐Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega‐analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between‐country transfer of subject‐level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as the approach taken to implement them. The goal is to document the approach and help guide other research groups working with large brain imaging data sets as they develop their own analytic pipelines for mega‐analyses. [ABSTRACT FROM AUTHOR]

Published
2022
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40. Mega‐analysis methods in ENIGMA : The experience of the generalized anxiety disorder working group

Author

Zugman, André, primary, Harrewijn, Anita, additional, Cardinale, Elise M., additional, Zwiebel, Hannah, additional, Freitag, Gabrielle F., additional, Werwath, Katy E., additional, Bas‐Hoogendam, Janna M., additional, Groenewold, Nynke A., additional, Aghajani, Moji, additional, Hilbert, Kevin, additional, Cardoner, Narcis, additional, Porta‐Casteràs, Daniel, additional, Gosnell, Savannah, additional, Salas, Ramiro, additional, Blair, Karina S., additional, Blair, James R., additional, Hammoud, Mira Z., additional, Milad, Mohammed, additional, Burkhouse, Katie, additional, Phan, K. Luan, additional, Schroeder, Heidi K., additional, Strawn, Jeffrey R., additional, Beesdo‐Baum, Katja, additional, Thomopoulos, Sophia I., additional, Grabe, Hans J., additional, Van der Auwera, Sandra, additional, Wittfeld, Katharina, additional, Nielsen, Jared A., additional, Buckner, Randy, additional, Smoller, Jordan W., additional, Mwangi, Benson, additional, Soares, Jair C., additional, Wu, Mon‐Ju, additional, Zunta‐Soares, Giovana B., additional, Jackowski, Andrea P., additional, Pan, Pedro M., additional, Salum, Giovanni A., additional, Assaf, Michal, additional, Diefenbach, Gretchen J., additional, Brambilla, Paolo, additional, Maggioni, Eleonora, additional, Hofmann, David, additional, Straube, Thomas, additional, Andreescu, Carmen, additional, Berta, Rachel, additional, Tamburo, Erica, additional, Price, Rebecca, additional, Manfro, Gisele G., additional, Critchley, Hugo D., additional, Makovac, Elena, additional, Mancini, Matteo, additional, Meeten, Frances, additional, Ottaviani, Cristina, additional, Agosta, Federica, additional, Canu, Elisa, additional, Cividini, Camilla, additional, Filippi, Massimo, additional, Kostić, Milutin, additional, Munjiza, Ana, additional, Filippi, Courtney A., additional, Leibenluft, Ellen, additional, Alberton, Bianca A. V., additional, Balderston, Nicholas L., additional, Ernst, Monique, additional, Grillon, Christian, additional, Mujica‐Parodi, Lilianne R., additional, Nieuwenhuizen, Helena, additional, Fonzo, Gregory A., additional, Paulus, Martin P., additional, Stein, Murray B., additional, Gur, Raquel E., additional, Gur, Ruben C., additional, Kaczkurkin, Antonia N., additional, Larsen, Bart, additional, Satterthwaite, Theodore D., additional, Harper, Jennifer, additional, Myers, Michael, additional, Perino, Michael T., additional, Yu, Qiongru, additional, Sylvester, Chad M., additional, Veltman, Dick J., additional, Lueken, Ulrike, additional, Van der Wee, Nic J. A., additional, Stein, Dan J., additional, Jahanshad, Neda, additional, Thompson, Paul M., additional, Pine, Daniel S., additional, and Winkler, Anderson M., additional

Published
2020
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42. Sexual Abuse in Adolescents Is Associated With Atypically Increased Responsiveness Within Regions Implicated in Self-Referential and Emotional Processing to Approaching Animate Threats

Author

Blair, Karina S., primary, Bashford-Largo, Johannah, additional, Shah, Niraj, additional, Lukoff, Jennie, additional, Elowsky, Jaimie, additional, Vogel, Steven, additional, Emmert, Amanda, additional, Zhang, Ru, additional, Dobbertin, Matthew, additional, Pollak, Seth, additional, and Blair, James R., additional

Published
2020
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43. Alcohol use disorder and cannabis use disorder symptomatology in adolescents is associated with dysfunction in neural processing of future events

Author

Aloi, Joseph, primary, Blair, Karina S., additional, Meffert, Harma, additional, White, Stuart F., additional, Hwang, Soonjo, additional, Tyler, Patrick M., additional, Crum, Kathleen I., additional, Thornton, Laura C., additional, Mobley, Alita, additional, Killanin, Abraham D., additional, Filbey, Francesca M., additional, Pope, Kayla, additional, and Blair, R. James, additional

Published
2020
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45. Interaction of irritability and anxiety on emotional responding and emotion regulation: a functional MRI study.

Author

Crum, Kathleen I., Hwang, Soonjo, Blair, Karina S., Aloi, Joseph M., Meffert, Harma, White, Stuart F., Tyler, Patrick M., Leibenluft, Ellen, Pope, Kayla, and Blair, R. J. R.

Subjects
SELF-control, MAGNETIC resonance imaging, ANXIETY, EMOTION regulation
Abstract

Background: Irritability and anxiety frequently co-occur in pediatric populations. Studies separately looking at the neural correlates of these symptoms have identified engagement of similar neural systems – particularly those implicated in emotional processing. Both irritability and anxiety can be considered negative valence emotional states that might relate to emotion dysregulation. However, previous work has not examined the neural responding during the performance of an emotion regulation task as a function of interaction between irritability and anxiety simultaneously. Methods: This fMRI study involved 155 participants (90 with significant psychopathologies and 92 male) who performed the Affective Stroop Task, designed to engage emotion regulation as a function of task demands. The Affective Reactivity Index (ARI) was used to index irritability and the Screen for Child Anxiety Related Emotional Disorders (SCARED) was used to index anxiety. Results: Levels of irritability, but not anxiety, was positively correlated with responses to visual images within the right rostro-medial prefrontal cortex and left anterior cingulate cortex during view trials. The second region of ventral anterior cingulate cortex showed a condition-by-emotion-by-ARI score-by-SCARED score interaction. Specifically, anxiety level was significantly correlated with a decreased differential BOLD response to negative relative to neutral view trials but only in the presence of relatively high irritability. Conclusions: Atypical maintenance of emotional stimuli within the rostro-medial prefrontal cortex may exacerbate the difficulties faced by adolescents with irritability. Moreover, increased anxiety combined with significant irritability may disrupt an automatic emotional conflict-based form of emotion regulation that is particularly associated with the ventral anterior cingulate cortex. [ABSTRACT FROM AUTHOR]

Published
2021
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47. Association of Different Types of Childhood Maltreatment With Emotional Responding and Response Control Among Youths

Author

Blair, Karina S., primary, Aloi, Joseph, additional, Crum, Kathleen, additional, Meffert, Harma, additional, White, Stuart F., additional, Taylor, Brittany K., additional, Leiker, Emily K., additional, Thornton, Laura C., additional, Tyler, Patrick M., additional, Shah, Niraj, additional, Johnson, Kimberly, additional, Abdel-Rahim, Heba, additional, Lukoff, Jennie, additional, Dobbertin, Matthew, additional, Pope, Kayla, additional, Pollak, Seth, additional, and Blair, R. James, additional

Published
2019
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48. Differential dysfunctions related to alcohol and cannabis use disorder symptoms in reward and error-processing neuro-circuitries in adolescents

Author

Aloi, Joseph, primary, Meffert, Harma, additional, White, Stuart F., additional, Blair, Karina S., additional, Hwang, Soonjo, additional, Tyler, Patrick M., additional, Thornton, Laura C., additional, Crum, Kathleen I., additional, Adams, Kathryn O., additional, Killanin, Abraham D., additional, Filbey, Francesca, additional, Pope, Kayla, additional, and Blair, R. James R., additional

Published
2019
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50. Alcohol use disorder and cannabis use disorder symptomatology in adolescents is associated with dysfunction in neural processing of future events.

Author

Aloi, Joseph, Blair, Karina S., Meffert, Harma, White, Stuart F., Hwang, Soonjo, Tyler, Patrick M., Crum, Kathleen I., Thornton, Laura C., Mobley, Alita, Killanin, Abraham D., Filbey, Francesca M., Pope, Kayla, and Blair, R. James

Subjects
*ALCOHOLISM, *OXYGEN in the blood, *TEENAGERS, *MARIJUANA abuse, *PREMOTOR cortex, *BRAIN, *RESEARCH, *SUBSTANCE abuse, *RESEARCH methodology, *MAGNETIC resonance imaging, *MEDICAL cooperation, *EVALUATION research, *COMPARATIVE studies, *RESEARCH funding, *EMOTIONS
Abstract

Two of the most commonly used substances by adolescents in the United States are cannabis and alcohol. Cannabis use disorder (CUD) and alcohol use disorder (AUD) are associated with impairments in decision-making processes. One mechanism for impaired decision-making in these individuals is thought to be an inability to adequately represent future events during decision-making. In the current study involving 112 adolescents, we used a comparative optimism task to examine the relationship between relative severity of CUD/AUD (as indexed by the CUD/AUD Identification Tests [CUDIT/AUDIT]) and atypical function within neural systems underlying affect-based neural represenation future events. Greater CUDIT scores were negatively related to responses within subgenual anterior and posterior cingulate cortex when processing high-intensity potential future positive and negative events. There was also a particularly marked negative relationship between CUD symptoms and blood oxygen level-dependent (BOLD) responses within visual and premotor cortices to high-intensity, negatively valenced potential future events. However, AUD symptom severity was not associated with dysfunction within these brain regions. These data indicate that relative risk/severity of CUD is associated with reduced responsiveness to future high-intensity events. This may impair decision-making where future significant consequences should guide response choice. [ABSTRACT FROM AUTHOR]

Published
2021
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