13 results on '"Bobak, D."'
Search Results
2. Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers
- Author
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Posth, C., Yu, H., Ghalichi, A., Rougier, H., Crevecoeur, I., Huang, Y., Ringbauer, H., Rohrlach, A., Nägele, K., Villalba-Mouco, V., Radzeviciute, R., Ferraz, T., Stoessel, A., Tukhbatova, R., Drucker, D., Lari, M., Modi, A., Vai, S., Saupe, T., Scheib, C., Catalano, G., Pagani, L., Talamo, S., Fewlass, H., Klaric, L., Morala, A., Rué, M., Madelaine, S., Crépin, L., Caverne, J., Bocaege, E., Ricci, S., Boschin, F., Bayle, P., Maureille, B., Le Brun-Ricalens, F., Bordes, J., Oxilia, G., Bortolini, E., Bignon-Lau, O., Debout, G., Orliac, M., Zazzo, A., Sparacello, V., Starnini, E., Sineo, L., van der Plicht, J., Pecqueur, L., Merceron, G., Garcia, G., Leuvrey, J., Garcia, C., Gómez-Olivencia, A., Połtowicz-Bobak, M., Bobak, D., Le Luyer, M., Storm, P., Hoffmann, C., Kabaciński, J., Filimonova, T., Shnaider, S., Berezina, N., González-Rabanal, B., Morales, G., R., M., Marín-Arroyo, A., López, B., Alonso-Llamazares, C., Ronchitelli, A., Polet, C., Jadin, I., Cauwe, N., Soler, J., Coromina, N., Rufí, I., Cottiaux, R., Clark, G., Straus, L., Julien, M., Renhart, S., Talaa, D., Benazzi, S., Romandini, M., Amkreutz, L., Bocherens, H., Wißing, C., Villotte, S., de Pablo, Fernández-López, J., Gómez-Puche, M., Esquembre-Bebia, M., Bodu, P., Smits, L., Souffi, B., Jankauskas, R., Kozakaitė, J., Cupillard, C., Benthien, H., Wehrberger, K., Schmitz, R., Feine, S., Schüler, T., Thevenet, C., Grigorescu, D., Lüth, F., Kotula, A., Piezonka, H., Schopper, F., Svoboda, J., Sázelová, S., Chizhevsky, A., Khokhlov, A., Conard, N., Valentin, F., Harvati, K., Semal, P., Jungklaus, B., Suvorov, A., Schulting, R., Moiseyev, V., Mannermaa, K., Buzhilova, A., Terberger, T., Caramelli, D., Altena, E., Haak, W., and Krause, J. more...
- Abstract
Modern humans have populated Europe for more than 45,000 years1,2. Our knowledge of the genetic relatedness and structure of ancient hunter-gatherers is however limited, owing to the scarceness and poor molecular preservation of human remains from that period3. Here we analyse 356 ancient hunter-gatherer genomes, including new genomic data for 116 individuals from 14 countries in western and central Eurasia, spanning between 35,000 and 5,000 years ago. We identify a genetic ancestry profile in individuals associated with Upper Palaeolithic Gravettian assemblages from western Europe that is distinct from contemporaneous groups related to this archaeological culture in central and southern Europe4, but resembles that of preceding individuals associated with the Aurignacian culture. This ancestry profile survived during the Last Glacial Maximum (25,000 to 19,000 years ago) in human populations from southwestern Europe associated with the Solutrean culture, and with the following Magdalenian culture that re-expanded northeastward after the Last Glacial Maximum. Conversely, we reveal a genetic turnover in southern Europe suggesting a local replacement of human groups around the time of the Last Glacial Maximum, accompanied by a north-to-south dispersal of populations associated with the Epigravettian culture. From at least 14,000 years ago, an ancestry related to this culture spread from the south across the rest of Europe, largely replacing the Magdalenian-associated gene pool. After a period of limited admixture that spanned the beginning of the Mesolithic, we find genetic interactions between western and eastern European hunter-gatherers, who were also characterized by marked differences in phenotypically relevant variants. Ancient DNA data generation Before the LGM LGM in southwestern and western Europe Post-LGM in the Italian peninsula Post-LGM in western and central Europe Post-14 ka to Neolithic Phenotypically relevant variants Discussion and conclusions Methods more...
- Published
- 2023
Catalog
3. Differential expression of endoplasmic reticulum stress-response proteins in different renal tubule subtypes of OVE26 diabetic mice
- Author
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Barati, Michelle T., Powell, David W., Kechavarzi, Bobak D., Isaacs, Susan M., Zheng, Shirong, Epstein, Paul N., Cai, Lu, Coventry, Susan, Rane, Madhavi J., and Klein, Jon B.
- Published
- 2016
4. Bottom-up, integrated -omics analysis identifies broadly dosage-sensitive genes in breast cancer samples from TCGA.
- Author
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Bobak D Kechavarzi, Huanmei Wu, and Thompson N Doman
- Subjects
Medicine ,Science - Abstract
The massive genomic data from The Cancer Genome Atlas (TCGA), including proteomics data from Clinical Proteomic Tumor Analysis Consortium (CPTAC), provides a unique opportunity to study cancer systematically. While most observations are made from a single type of genomics data, we apply big data analytics and systems biology approaches by simultaneously analyzing DNA amplification, mRNA and protein abundance. Using multiple genomic profiles, we have discovered widespread dosage compensation for the extensive aneuploidy observed in TCGA breast cancer samples. We do identify 11 genes that show strong correlation across all features (DNA/mRNA/protein) analogous to that of the well-known oncogene HER2 (ERBB2). These genes are generally less well-characterized regarding their role in cancer and we advocate their further study. We also discover that shRNA knockdown of these genes has an impact on cancer cell growth, suggesting a vulnerability that could be used for cancer therapy. Our study shows the advantages of systematic big data methodologies and also provides future research directions. more...
- Published
- 2019
- Full Text
- View/download PDF
5. THE LATE MAGDALENIAN IN POLAND — NEW DATA, NEW ISSUES
- Author
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Połtowicz-Bobak, M., primary and Bobak, D., additional
- Published
- 2022
- Full Text
- View/download PDF
6. Cultural evolution and environmental change in Central Europe between 40 and 15 ka
- Author
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Maier, Andreas, Stojakowits, P., Mayr, C., Pfeifer, S., Preusser, F., Zolitschka, B., Anghelinu, M., Bobak, D., Duprat-Oualid, F., Einwögerer, T., Hambach, U., Händel, M., Kaminská, L., Kämpf, L., Łanczont, M., Lehmkuhl, F., Ludwig, P., Magyari, E., Mroczek, P., Nemergut, A., Nerudová, Z., Niţă, L., Polanská, M., Połtowicz-Bobak, M., Rius, D., Römer, W., Simon, U., Škrdla, P., Újvári, G., Veres, D., Maier, Andreas, Stojakowits, P., Mayr, C., Pfeifer, S., Preusser, F., Zolitschka, B., Anghelinu, M., Bobak, D., Duprat-Oualid, F., Einwögerer, T., Hambach, U., Händel, M., Kaminská, L., Kämpf, L., Łanczont, M., Lehmkuhl, F., Ludwig, P., Magyari, E., Mroczek, P., Nemergut, A., Nerudová, Z., Niţă, L., Polanská, M., Połtowicz-Bobak, M., Rius, D., Römer, W., Simon, U., Škrdla, P., Újvári, G., and Veres, D. more...
- Abstract
The role of environmental change in the evolution of cultural traits is a topic of long-standing scientific debate with strongly contrasting views. Major obstacles for assessing environmental impacts on the evolution of material culture are the fragmentary nature of archaeological and – to a somewhat lesser extent – geoscientific archives and the insufficient chronological resolution of these archives and related proxy data. Together these aspects are causing difficulties in data synchronization. By no means does this paper attempt to solve these issues, but rather aims at shifting the focus from demonstrating strict chains of causes and events to describing roughly contemporaneous developments by compiling and comparing existing evidence from archaeology and geosciences for the period between 40 and 15 ka in Central Europe. Analysis of the archaeological record identifies five instances at around 33, 29, 23.5, 19, and 16 ka, for which evidence suggests an increased speed of cultural evolution. By comparing data from different geoscientific archives, we discuss whether or not these instances have common characteristics. We stress that common characteristics per se are no proof of causality; repeated co-occurrences of certain features over long periods of time, however, suggest that certain explanations may be more plausible than others. While all five cases roughly coincide with pronounced and rapid environmental changes, it is also observed that such conditions do not necessarily trigger major changes in the material culture. Increases and decreases in the diversity of cultural traits seem to be rather correlated with the overall demographic development. In compiling and comparing our data, we also identify periods with high need and potential for future research regarding the relation between environmental change and cultural evolution. more...
- Published
- 2020
7. Differential expression of endoplasmic reticulum stress-response proteins in different renal tubule subtypes of OVE26 diabetic mice
- Author
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Susan Coventry, David W. Powell, Michelle T. Barati, Jon B. Klein, Shirong Zheng, Lu Cai, Bobak D. Kechavarzi, Paul N. Epstein, Madhavi J. Rane, and Susan Isaacs
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Protein Disulfide-Isomerases ,Apoptosis ,Mice, Transgenic ,CHOP ,Biochemistry ,Cell Line ,Kidney Tubules, Proximal ,Diabetic nephropathy ,Mice ,eIF-2 Kinase ,03 medical and health sciences ,Downregulation and upregulation ,Internal medicine ,Diabetes Mellitus ,medicine ,Animals ,Humans ,Phosphorylation ,RNA, Small Interfering ,Kidney Tubules, Distal ,Protein disulfide-isomerase ,Protein kinase A ,Endoplasmic Reticulum Chaperone BiP ,Heat-Shock Proteins ,Transcription Factor CHOP ,Original Paper ,Membrane Glycoproteins ,Chemistry ,Endoplasmic reticulum ,Age Factors ,Cell Biology ,HSP40 Heat-Shock Proteins ,Endoplasmic Reticulum Stress ,medicine.disease ,Fibronectins ,Up-Regulation ,Disease Models, Animal ,Proteinuria ,030104 developmental biology ,Tubule ,Endocrinology ,Female ,RNA Interference - Abstract
Regulation of the endoplasmic reticulum (ER) stress-response pathway during the course of diabetes specifically in renal tubules is unclear. Since tubule cell dysfunction is critical to progression of diabetic nephropathy, this study analyzed markers of ER stress response and ER chaperones at different stages of diabetes and in different renal tubule subtypes of OVE26 type-1 diabetic mice. ER stress-response-induced chaperones GRP78, GRP94, and protein disulfide isomerase (PDI) were increased in isolated cortical tubules of older diabetic mice, while PDI was decreased in tubules of young diabetic mice. Immunofluorescence staining of kidneys from older mice showed GRP78 and PDI upregulation in all cortical tubule segments, with substantial induction of PDI in distal tubules. Protein kinase RNA-like endoplasmic reticulum kinase (PERK) phosphorylation was increased in cortical tubules of young diabetic mice, with no differences between older diabetic and control mice. Expression of ER stress-induced PERK inhibitor p58IPK was decreased and then increased in all tubule subtypes of young and older mice, respectively. Knockdown of PERK by small interfering RNA (siRNA) increased fibronectin secretion in cultured proximal tubule cells. Tubules of older diabetic mice had significantly more apoptotic cells, and ER stress-induced pro-apoptotic transcription factor C/EBP homologous protein (CHOP) was increased in proximal and distal tubules of diabetic mice and diabetic humans. CHOP induction in OVE26 mice was not altered by severity of proteinuria. Overexpression of CHOP in cultured proximal tubule cells increased expression of fibronectin. These findings demonstrate differential ER stress-response signaling in tubule subtypes of diabetic mice and implicate a role for PERK and CHOP in tubule cell matrix protein production. more...
- Published
- 2015
- Full Text
- View/download PDF
8. Bottom-up, integrated -omics analysis identifies broadly dosage-sensitive genes in breast cancer samples from TCGA
- Author
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Kechavarzi, Bobak D., primary, Wu, Huanmei, additional, and Doman, Thompson N., additional
- Published
- 2019
- Full Text
- View/download PDF
9. Bottom-up, integrated -omics analysis identifies broadly dosage-sensitive genes in breast cancer samples from TCGA
- Author
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Thompson N. Doman, Huanmei Wu, and Bobak D. Kechavarzi
- Subjects
Proteomics ,Big Data ,0301 basic medicine ,Gene Dosage ,Gene Expression ,Biochemistry ,0302 clinical medicine ,Breast Tumors ,Basic Cancer Research ,Databases, Genetic ,Gene duplication ,Medicine and Health Sciences ,RNA, Neoplasm ,Multidisciplinary ,Messenger RNA ,Systems Biology ,Genomics ,DNA, Neoplasm ,Neoplasm Proteins ,Nucleic acids ,Oncology ,Gene Knockdown Techniques ,030220 oncology & carcinogenesis ,Medicine ,Female ,Research Article ,DNA Copy Number Variations ,Science ,Systems biology ,Breast Neoplasms ,Computational biology ,Biology ,Gene dosage ,03 medical and health sciences ,Cancer Genomics ,Breast cancer ,Genomic Medicine ,Breast Cancer ,Genetics ,Cancer Genetics ,medicine ,Humans ,RNA, Messenger ,Gene ,Biology and life sciences ,Gene Expression Profiling ,Gene Amplification ,Cancers and Neoplasms ,Oncogenes ,Genes, erbB-2 ,Aneuploidy ,medicine.disease ,Gene expression profiling ,030104 developmental biology ,RNA ,Departures from Diploidy ,Protein Abundance - Abstract
The massive genomic data from The Cancer Genome Atlas (TCGA), including proteomics data from Clinical Proteomic Tumor Analysis Consortium (CPTAC), provides a unique opportunity to study cancer systematically. While most observations are made from a single type of genomics data, we apply big data analytics and systems biology approaches by simultaneously analyzing DNA amplification, mRNA and protein abundance. Using multiple genomic profiles, we have discovered widespread dosage compensation for the extensive aneuploidy observed in TCGA breast cancer samples. We do identify 11 genes that show strong correlation across all features (DNA/mRNA/protein) analogous to that of the well-known oncogene HER2 (ERBB2). These genes are generally less well-characterized regarding their role in cancer and we advocate their further study. We also discover that shRNA knockdown of these genes has an impact on cancer cell growth, suggesting a vulnerability that could be used for cancer therapy. Our study shows the advantages of systematic big data methodologies and also provides future research directions. more...
- Published
- 2019
- Full Text
- View/download PDF
10. The RESET project: Constructing a European tephra lattice for refined synchronisation of environmental and archaeological events during the last c. 100 ka
- Author
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Lowe, John J, Ramsey, Christopher Bronk, Housley, Rupert A., Lane, Christine S., Tomlinson, Emma L., Stringer, Chris, Davies, William, Barton, Nick, Pollard, Mark, Gamble, Clive, Menzies, Martin, Rohling, Eelco, Roberts, Andrew, Blockley, Simon, Cullen, Victoria, Grant, Katharine, Lewis, Mark, Macleod, Alison, White, Dustin, Albert, Paul, Hardiman, Mark, Lee, Sharen, Anna, Oh, Satow, Christopher, Cross, Joanna K., Law, Cassian Bramham, Todman, Anna, Bourne, Anna, Matthews, Ian, Müller, Wolfgang, Smith, Victoria, Wulf, Sabine, Anghelinu, M., Antl Weiser, W., Bar Yosef, O., Boric, D., Boscato, P., Ronchitelli, A., Chabai, V., Veselsky, A., Uthmeier, T., Farrand, W., Gjipali, I., Ruka, R., Güleç, E., Karavanic, I., Karkanas, P., King, T., Komšo, D., Koumouzelis, M., Kyparissi, N., Lengyel, G., Mester, Z., Neruda, P., Panagopoulou, E., Shalamanov Korobar, L., Tolevski, I., Sirakov, N., Guadelli, A., Guadelli, J. L., Ferrier, C., Skrdla, P., Slimak, L., Soler, N., Soler, J., Soressi, M., Tushabramishvilii, N., Zilhão, J., Angelucci, D., Albert, P., Bramham Law, C., Cullen, V. L., Lincoln, P., Staff, R., Flower, K., Aouadi Abdeljaouad, N., Belhouchet, L., Barker, G., Bouzouggar, A., Van Peer, P., Kindermann, K., Gerken, K., Niemann, H., Tipping, R., Saville, A., Ward, T., Clausen, I., Weber, M. J., Kaiser, K., Torksdorf, J. F., Turner, F., Veil, S., Nygaard, N., Pyne O'Donnell, S. D. F., Masojc, M., Nalepka, D., Jurochnik, A., Kabacinski, J., Antoine, P., Olive, M., Christensen, M., Bodu, P., Debout, G., Orliac, M., De Bie, M., Van Gils, M., Paulissen, E., Brou, L., Leesch, D., Hadorn, P., Thew, N., Riede, F., Heinen, M., Joris, O., Richter, J., Knipping, M., Stika, H. P., Friedrich, M., Conard, N., Malina, M., Kind, C. J., Beutelspacher, T., Mortensen, M. F., Burdukiewicz, J. M., Szynkiewicz, A., Poltowicz Bobak, M., Bobak, D., Wisniewski, A., Przezdziecki, M., Valde Nowak, P., Muzyczuk, A., Davies, L., Macleod, A., Morgan, P., Aydar, Erkan, Çubukçu, Evren, Brown, Richard, Coltelli, Mauro, Castro, Deborah Lo, Cioni, Raffaello, Derosa, Rosanna, Donato, Paola, Roberto, Alessio Di, Gertisser, Ralf, Giordano, Guido, Branney, Mike, Jordan, Nina, Keller, Jörg, Kinvig, Helen, Gottsman, Jo, Blundy, Jon, Marani, Michael, Orsi, Giovanni, Civetta, Lucia, Arienzo, Ilenia, Carandente, Antonio, Rosi, Mauro, Zanchetta, Giovanni, Seghedi, Ioan, Szakacs, Alex, Sulpizio, Roberto, Thordarson, Thor, Trincardi, Fabio, Vigliotti, Luigi, Asioli, Alesssandra, Piva, Andrea, Andric, M., Brauer, A., de Klerk, P., Filippi, M. L., Finsinger, W., Galovic, L., Jones, T., Lotter, A., Müller, U., Pross, J., Mangerud, J., Lohne, Ø., Pyne O'Donnell, S., Markovic, S., Pini, R., Ravazzi, C., Theuerkauf, M., Tzedakis, C., Margari, V., Veres, D., Wastegård, S., Ortiz, J. E., Torres, T., Díaz Bautista, A., Moreno, A., Valero Garcés, B., Lowick, S., Ottolini, Lusia, John J. Lowe a,, Christopher Bronk Ramsey, B, A, Rupert A. Housley, B, Christine S. Lane, C, Emma L. Tomlinson, Team, Reset, and Giordano, Guido more...
- Subjects
Archeology ,Environmental change ,Evolution ,Dansgaard–Oeschger and Heinrich events ,Abrupt environmental transitions (AETs) ,Dansgaard-Oeschger and Heinrich events ,Last Glacial stage ,Middle to Upper Palaeolithic ,Tephra database ,Tephra geochemistry ,Volcanic ash isochrons ,Geology ,Global and Planetary Change ,Ecology, Evolution, Behavior and Systematics ,Archeology (arts and humanities) ,Behavior and Systematics ,Glacial period ,Tephra ,Holocene ,Isochron dating ,Ecology ,Volcanic ash isochron ,Tephra geochemistr ,Quaternary science ,Archaeology ,Ecology, Evolution, Behavior and Systematic ,Dansgaard-Oeschger and Heinrich event ,Mainland ,Physical geography - Abstract
This paper introduces the aims and scope of the RESET project (. RESponse of humans to abrupt Environmental Transitions), a programme of research funded by the Natural Environment Research Council (UK) between 2008 and 2013; it also provides the context and rationale for papers included in a special volume of Quaternary Science Reviews that report some of the project's findings. RESET examined the chronological and correlation methods employed to establish causal links between the timing of abrupt environmental transitions (AETs) on the one hand, and of human dispersal and development on the other, with a focus on the Middle and Upper Palaeolithic periods. The period of interest is the Last Glacial cycle and the early Holocene (c. 100-8 ka), during which time a number of pronounced AETs occurred. A long-running topic of debate is the degree to which human history in Europe and the Mediterranean region during the Palaeolithic was shaped by these AETs, but this has proved difficult to assess because of poor dating control. In an attempt to move the science forward, RESET examined the potential that tephra isochrons, and in particular non-visible ash layers (cryptotephras), might offer for synchronising palaeo-records with a greater degree of finesse. New tephrostratigraphical data generated by the project augment previously-established tephra frameworks for the region, and underpin a more evolved tephra 'lattice' that links palaeo-records between Greenland, the European mainland, sub-marine sequences in the Mediterranean and North Africa. The paper also outlines the significance of other contributions to this special volume: collectively, these illustrate how the lattice was constructed, how it links with cognate tephra research in Europe and elsewhere, and how the evidence of tephra isochrons is beginning to challenge long-held views about the impacts of environmental change on humans during the Palaeolithic. © 2015 Elsevier Ltd., RESET was funded through Consortium Grants awarded by the Natural Environment Research Council, UK, to a collaborating team drawn from four institutions: Royal Holloway University of London (grant reference NE/E015905/1), the Natural History Museum, London (NE/E015913/1), Oxford University (NE/E015670/1) and the University of Southampton, including the National Oceanography Centre (NE/01531X/1). The authors also wish to record their deep gratitude to four members of the scientific community who formed a consultative advisory panel during the lifetime of the RESET project: Professor Barbara Wohlfarth (Stockholm University), Professor Jørgen Peder Steffensen (Niels Bohr Institute, Copenhagen), Dr. Martin Street (Romisch-Germanisches Zentralmuseum, Neuwied) and Professor Clive Oppenheimer (Cambridge University). They provided excellent advice at key stages of the work, which we greatly valued. We also thank Jenny Kynaston (Geography Department, Royal Holloway) for construction of several of the figures in this paper, and Debbie Barrett (Elsevier) and Colin Murray Wallace (Editor-in-Chief, QSR) for their considerable assistance in the production of this special volume. more...
- Published
- 2015
- Full Text
- View/download PDF
11. Differential expression of endoplasmic reticulum stress-response proteins in different renal tubule subtypes of OVE26 diabetic mice
- Author
-
Barati, Michelle T., primary, Powell, David W., additional, Kechavarzi, Bobak D., additional, Isaacs, Susan M., additional, Zheng, Shirong, additional, Epstein, Paul N., additional, Cai, Lu, additional, Coventry, Susan, additional, Rane, Madhavi J., additional, and Klein, Jon B., additional more...
- Published
- 2015
- Full Text
- View/download PDF
12. Author Correction: Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers.
- Author
-
Posth C, Yu H, Ghalichi A, Rougier H, Crevecoeur I, Huang Y, Ringbauer H, Rohrlach AB, Nägele K, Villalba-Mouco V, Radzeviciute R, Ferraz T, Stoessel A, Tukhbatova R, Drucker DG, Lari M, Modi A, Vai S, Saupe T, Scheib CL, Catalano G, Pagani L, Talamo S, Fewlass H, Klaric L, Morala A, Rué M, Madelaine S, Crépin L, Caverne JB, Bocaege E, Ricci S, Boschin F, Bayle P, Maureille B, Le Brun-Ricalens F, Bordes JG, Oxilia G, Bortolini E, Bignon-Lau O, Debout G, Orliac M, Zazzo A, Sparacello V, Starnini E, Sineo L, van der Plicht J, Pecqueur L, Merceron G, Garcia G, Leuvrey JM, Garcia CB, Gómez-Olivencia A, Połtowicz-Bobak M, Bobak D, Le Luyer M, Storm P, Hoffmann C, Kabaciński J, Filimonova T, Shnaider S, Berezina N, González-Rabanal B, González Morales MR, Marín-Arroyo AB, López B, Alonso-Llamazares C, Ronchitelli A, Polet C, Jadin I, Cauwe N, Soler J, Coromina N, Rufí I, Cottiaux R, Clark G, Straus LG, Julien MA, Renhart S, Talaa D, Benazzi S, Romandini M, Amkreutz L, Bocherens H, Wißing C, Villotte S, de Pablo JF, Gómez-Puche M, Esquembre-Bebia MA, Bodu P, Smits L, Souffi B, Jankauskas R, Kozakaitė J, Cupillard C, Benthien H, Wehrberger K, Schmitz RW, Feine SC, Schüler T, Thevenet C, Grigorescu D, Lüth F, Kotula A, Piezonka H, Schopper F, Svoboda J, Sázelová S, Chizhevsky A, Khokhlov A, Conard NJ, Valentin F, Harvati K, Semal P, Jungklaus B, Suvorov A, Schulting R, Moiseyev V, Mannermaa K, Buzhilova A, Terberger T, Caramelli D, Altena E, Haak W, and Krause J more...
- Published
- 2023
- Full Text
- View/download PDF
13. Palaeogenomics of Upper Palaeolithic to Neolithic European hunter-gatherers.
- Author
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Posth C, Yu H, Ghalichi A, Rougier H, Crevecoeur I, Huang Y, Ringbauer H, Rohrlach AB, Nägele K, Villalba-Mouco V, Radzeviciute R, Ferraz T, Stoessel A, Tukhbatova R, Drucker DG, Lari M, Modi A, Vai S, Saupe T, Scheib CL, Catalano G, Pagani L, Talamo S, Fewlass H, Klaric L, Morala A, Rué M, Madelaine S, Crépin L, Caverne JB, Bocaege E, Ricci S, Boschin F, Bayle P, Maureille B, Le Brun-Ricalens F, Bordes JG, Oxilia G, Bortolini E, Bignon-Lau O, Debout G, Orliac M, Zazzo A, Sparacello V, Starnini E, Sineo L, van der Plicht J, Pecqueur L, Merceron G, Garcia G, Leuvrey JM, Garcia CB, Gómez-Olivencia A, Połtowicz-Bobak M, Bobak D, Le Luyer M, Storm P, Hoffmann C, Kabaciński J, Filimonova T, Shnaider S, Berezina N, González-Rabanal B, González Morales MR, Marín-Arroyo AB, López B, Alonso-Llamazares C, Ronchitelli A, Polet C, Jadin I, Cauwe N, Soler J, Coromina N, Rufí I, Cottiaux R, Clark G, Straus LG, Julien MA, Renhart S, Talaa D, Benazzi S, Romandini M, Amkreutz L, Bocherens H, Wißing C, Villotte S, de Pablo JF, Gómez-Puche M, Esquembre-Bebia MA, Bodu P, Smits L, Souffi B, Jankauskas R, Kozakaitė J, Cupillard C, Benthien H, Wehrberger K, Schmitz RW, Feine SC, Schüler T, Thevenet C, Grigorescu D, Lüth F, Kotula A, Piezonka H, Schopper F, Svoboda J, Sázelová S, Chizhevsky A, Khokhlov A, Conard NJ, Valentin F, Harvati K, Semal P, Jungklaus B, Suvorov A, Schulting R, Moiseyev V, Mannermaa K, Buzhilova A, Terberger T, Caramelli D, Altena E, Haak W, and Krause J more...
- Subjects
- Humans, Europe ethnology, Gene Pool, History, Ancient, Archaeology, Genomics, Hunting, Paleontology, Human Genetics, Genome, Human genetics
- Abstract
Modern humans have populated Europe for more than 45,000 years
1,2 . Our knowledge of the genetic relatedness and structure of ancient hunter-gatherers is however limited, owing to the scarceness and poor molecular preservation of human remains from that period3 . Here we analyse 356 ancient hunter-gatherer genomes, including new genomic data for 116 individuals from 14 countries in western and central Eurasia, spanning between 35,000 and 5,000 years ago. We identify a genetic ancestry profile in individuals associated with Upper Palaeolithic Gravettian assemblages from western Europe that is distinct from contemporaneous groups related to this archaeological culture in central and southern Europe4 , but resembles that of preceding individuals associated with the Aurignacian culture. This ancestry profile survived during the Last Glacial Maximum (25,000 to 19,000 years ago) in human populations from southwestern Europe associated with the Solutrean culture, and with the following Magdalenian culture that re-expanded northeastward after the Last Glacial Maximum. Conversely, we reveal a genetic turnover in southern Europe suggesting a local replacement of human groups around the time of the Last Glacial Maximum, accompanied by a north-to-south dispersal of populations associated with the Epigravettian culture. From at least 14,000 years ago, an ancestry related to this culture spread from the south across the rest of Europe, largely replacing the Magdalenian-associated gene pool. After a period of limited admixture that spanned the beginning of the Mesolithic, we find genetic interactions between western and eastern European hunter-gatherers, who were also characterized by marked differences in phenotypically relevant variants., (© 2023. The Author(s).) more...- Published
- 2023
- Full Text
- View/download PDF
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