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Your search keyword '"Bogorad, Roman L"' showing total 24 results
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24 results on '"Bogorad, Roman L"'

4. Liver-Specific siRNA-Mediated Stat3 or C3 Knockdown Improves the Outcome of Experimental Autoimmune Myocarditis

Author

Avalle, Lidia, primary, Marino, Francesca, additional, Camporeale, Annalisa, additional, Guglielmi, Chiara, additional, Viavattene, Daniele, additional, Bandini, Silvio, additional, Conti, Laura, additional, Cimino, James, additional, Forni, Marco, additional, Zanini, Cristina, additional, Ghigo, Alessandra, additional, Bogorad, Roman L., additional, Cavallo, Federica, additional, Provero, Paolo, additional, Koteliansky, Victor, additional, and Poli, Valeria, additional

Published
2020
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5. Liquid-crystal organization of liver tissue

Author

Morales-Navarrete, Hernán, primary, Nonaka, Hidenori, additional, Scholich, André, additional, Segovia-Miranda, Fabián, additional, de Back, Walter, additional, Meyer, Kirstin, additional, Bogorad, Roman L, additional, Koteliansky, Victor, additional, Brusch, Lutz, additional, Kalaidzidis, Yannis, additional, Jülicher, Frank, additional, Friedrich, Benjamin M, additional, and Zerial, Marino, additional

Published
2019
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6. Author response: Liquid-crystal organization of liver tissue

Author

Morales-Navarrete, Hernán, primary, Nonaka, Hidenori, additional, Scholich, André, additional, Segovia-Miranda, Fabián, additional, de Back, Walter, additional, Meyer, Kirstin, additional, Bogorad, Roman L, additional, Koteliansky, Victor, additional, Brusch, Lutz, additional, Kalaidzidis, Yannis, additional, Jülicher, Frank, additional, Friedrich, Benjamin M, additional, and Zerial, Marino, additional

Published
2019
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7. Liquid-crystal organization of liver tissue

Author

Morales-Navarrete, Hernán, primary, Nonaka, Hidenori, additional, Scholich, André, additional, Segovia-Miranda, Fabián, additional, de Back, Walter, additional, Meyer, Kirstin, additional, Bogorad, Roman L., additional, Koteliansky, Victor, additional, Brusch, Lutz, additional, Kalaidzidis, Yannis, additional, Jülicher, Frank, additional, Friedrich, Benjamin M., additional, and Zerial, Marino, additional

Published
2018
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8. Large-Scale Quantitative Proteomics Identifies the Ubiquitin Ligase Nedd4-1 as an Essential Regulator of Liver Regeneration

Author

Bachofner, Marc, Speicher, Tobias, Bogorad, Roman L, Muzumdar, Sukalp, Derrer, Carina P, Hürlimann, Fabrizio, Böhm, Friederike, Nanni, Paolo, Kockmann, Tobias, Kachaylo, Ekaterina, Meyer, Michael, Padrissa-Altés, Susagna, Graf, Rolf, Anderson, Daniel G, Koteliansky, Victor, Auf dem Keller, Ulrich, Werner, Sabine, University of Zurich, and Werner, Sabine

Subjects
1309 Developmental Biology, 1307 Cell Biology, 1300 General Biochemistry, Genetics and Molecular Biology, 1312 Molecular Biology, 570 Life sciences, biology, 610 Medicine & health, 10071 Functional Genomics Center Zurich, 10217 Clinic for Visceral and Transplantation Surgery
Published
2017

9. Partial DNA-guided Cas9 enables genome editing with reduced off-target activity

Author

Yin, Hao, primary, Song, Chun-Qing, additional, Suresh, Sneha, additional, Kwan, Suet-Yan, additional, Wu, Qiongqiong, additional, Walsh, Stephen, additional, Ding, Junmei, additional, Bogorad, Roman L, additional, Zhu, Lihua Julie, additional, Wolfe, Scot A, additional, Koteliansky, Victor, additional, Xue, Wen, additional, Langer, Robert, additional, and Anderson, Daniel G, additional

Published
2018
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11. Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing

Author

Yin, Hao, primary, Song, Chun-Qing, additional, Suresh, Sneha, additional, Wu, Qiongqiong, additional, Walsh, Stephen, additional, Rhym, Luke Hyunsik, additional, Mintzer, Esther, additional, Bolukbasi, Mehmet Fatih, additional, Zhu, Lihua Julie, additional, Kauffman, Kevin, additional, Mou, Haiwei, additional, Oberholzer, Alicia, additional, Ding, Junmei, additional, Kwan, Suet-Yan, additional, Bogorad, Roman L, additional, Zatsepin, Timofei, additional, Koteliansky, Victor, additional, Wolfe, Scot A, additional, Xue, Wen, additional, Langer, Robert, additional, and Anderson, Daniel G, additional

Published
2017
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12. Control of liver size by RNAi-mediated multiplex knockdown and its application for discovery of regulatory mechanisms

Author

Yin, Hao, Bogorad, Roman L., Barnes, Carmen, Walsha, Stephen, Zhuang, Iris, Nonaka, Hidenori, Ruda, Vera, Kuchimanchi, Satya, Nechev, Lubomir, Akinc, Akin, Xue, Wen, Zerial, Marino, Langer, Robert, Anderson, Daniel G., and Koteliansky, Victor

Subjects
Hepatocyte Growth Factor, Gene Expression, Cell Cycle Proteins, YAP-Signaling Proteins, Genomics, Organ Size, Protein Serine-Threonine Kinases, Phosphoproteins, Serine-Threonine Kinase 3, Article, Mice, Inbred C57BL, Mice, Liver, Genes, Neurofibromatosis 2, Proto-Oncogene Proteins, Animals, Nanoparticles, RNA Interference, Tumor Suppressor Protein p53, Adaptor Proteins, Signal Transducing, Hepatomegaly
Abstract

The Hippo pathway controls organ size through a negative regulation of the transcription co-activator Yap1. The overexpression of hyperactive mutant Yap1 or deletion of key components in the Hippo pathway leads to increased organ size in different species. Analysis of interactions of this pathway with other cellular signals corroborating organ size control is limited in part due to the difficulties associated with development of rodent models.Here, we develop a new model of reversible induction of the liver size in mice using siRNA-nanoparticles targeting two kinases of the Hippo pathway, namely, mammalian Ste20 family kinases 1 and 2 (Mst1 and Mst2), and an upstream regulator, neurofibromatosis type II (Nf2).The triple siRNAs nanoparticle-induced hepatomegaly in mice phenocopies one observed with Mst1(-/-)Mst2(-/-) liver-specific depletion, as shown by extensive proliferation of hepatocytes and activation of Yap1. The simultaneous co-treatment with a fourth siRNA nanoparticle against Yap1 fully blocked the liver growth. Hippo pathway-induced liver enlargement is associated with p53 activation, evidenced by its accumulation in the nuclei and upregulation of its target genes. Moreover, injections of the triple siRNAs nanoparticle in p53(LSL/LSL) mice shows that livers lacking p53 expression grow faster and exceed the size of livers in p53 wild-type animals, indicating a role of p53 in controlling Yap1-induced liver growth.Our data show that siRNA-nanoparticulate manipulation of gene expression can provide the reversible control of organ size in adult animals, which presents a new avenue for the investigation of complex regulatory networks in liver.

Published
2015

13. Large-Scale Quantitative Proteomics Identifies the Ubiquitin Ligase Nedd4-1 as an Essential Regulator of Liver Regeneration

Author

Bachofner, Marc, primary, Speicher, Tobias, additional, Bogorad, Roman L., additional, Muzumdar, Sukalp, additional, Derrer, Carina P., additional, Hürlimann, Fabrizio, additional, Böhm, Friederike, additional, Nanni, Paolo, additional, Kockmann, Tobias, additional, Kachaylo, Ekaterina, additional, Meyer, Michael, additional, Padrissa-Altés, Susagna, additional, Graf, Rolf, additional, Anderson, Daniel G., additional, Koteliansky, Victor, additional, auf dem Keller, Ulrich, additional, and Werner, Sabine, additional

Published
2017
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14. Cell-Cycle-Targeting MicroRNAs as Therapeutic Tools against Refractory Cancers

Author

Hydbring, Per, primary, Wang, Yinan, additional, Fassl, Anne, additional, Li, Xiaoting, additional, Matia, Veronica, additional, Otto, Tobias, additional, Choi, Yoon Jong, additional, Sweeney, Katharine E., additional, Suski, Jan M., additional, Yin, Hao, additional, Bogorad, Roman L., additional, Goel, Shom, additional, Yuzugullu, Haluk, additional, Kauffman, Kevin J., additional, Yang, Junghoon, additional, Jin, Chong, additional, Li, Yingxiang, additional, Floris, Davide, additional, Swanson, Richard, additional, Ng, Kimmie, additional, Sicinska, Ewa, additional, Anders, Lars, additional, Zhao, Jean J., additional, Polyak, Kornelia, additional, Anderson, Daniel G., additional, Li, Cheng, additional, and Sicinski, Piotr, additional

Published
2017
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15. Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

Author

Yin, Hao, primary, Song, Chun-Qing, additional, Dorkin, Joseph R, additional, Zhu, Lihua J, additional, Li, Yingxiang, additional, Wu, Qiongqiong, additional, Park, Angela, additional, Yang, Junghoon, additional, Suresh, Sneha, additional, Bizhanova, Aizhan, additional, Gupta, Ankit, additional, Bolukbasi, Mehmet F, additional, Walsh, Stephen, additional, Bogorad, Roman L, additional, Gao, Guangping, additional, Weng, Zhiping, additional, Dong, Yizhou, additional, Koteliansky, Victor, additional, Wolfe, Scot A, additional, Langer, Robert, additional, Xue, Wen, additional, and Anderson, Daniel G, additional

Published
2016
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16. Regulation of Liver Metabolism by the Endosomal GTPase Rab5

Author

Zeigerer, Anja, primary, Bogorad, Roman L., additional, Sharma, Kirti, additional, Gilleron, Jerome, additional, Seifert, Sarah, additional, Sales, Susanne, additional, Berndt, Nikolaus, additional, Bulik, Sascha, additional, Marsico, Giovanni, additional, D’Souza, Rochelle C.J., additional, Lakshmanaperumal, Naharajan, additional, Meganathan, Kesavan, additional, Natarajan, Karthick, additional, Sachinidis, Agapios, additional, Dahl, Andreas, additional, Holzhütter, Hermann-Georg, additional, Shevchenko, Andrej, additional, Mann, Matthias, additional, Koteliansky, Victor, additional, and Zerial, Marino, additional

Published
2015
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17. Residue 146 regulates prolactin receptor folding, basal activity and ligand-responsiveness: Potential implications in breast tumorigenesis

Author

Zhang, Chi, primary, Cherifi, Ibtissem, additional, Nygaard, Mads, additional, Haxholm, Gitte W., additional, Bogorad, Roman L., additional, Bernadet, Marie, additional, England, Patrick, additional, Broutin, Isabelle, additional, Kragelund, Birthe B., additional, Guidotti, Jacques-Emmanuel, additional, and Goffin, Vincent, additional

Published
2015
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18. Control of hepatocyte proliferation and survival by Fgf receptors is essential for liver regeneration in mice

Author

Padrissa-Altés, Susagna, primary, Bachofner, Marc, additional, Bogorad, Roman L, additional, Pohlmeier, Lea, additional, Rossolini, Thomas, additional, Böhm, Friederike, additional, Liebisch, Gerhard, additional, Hellerbrand, Claus, additional, Koteliansky, Victor, additional, Speicher, Tobias, additional, and Werner, Sabine, additional

Published
2014
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19. Loss of α-catenin elicits a cholestatic response and impairs liver regeneration

Author

Herr, Keira Joann, primary, Tsang, Ying-hung Nicole, additional, Ong, Joanne Wei En, additional, Li, Qiushi, additional, Yap, Lai Lai, additional, Yu, Weimiao, additional, Yin, Hao, additional, Bogorad, Roman L., additional, Dahlman, James E., additional, Chan, Yee Gek, additional, Bay, Boon Huat, additional, Singaraja, Roshni, additional, Anderson, Daniel G., additional, Koteliansky, Victor, additional, Viasnoff, Virgile, additional, and Thiery, Jean Paul, additional

Published
2014
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22. Loss of α-catenin elicits a cholestatic response and impairs liver regeneration.

Author

Keira Joann Herr, Ying-hung Nicole Tsang, Joanne Wei En Ong, Qiushi Li, Lai Lai Yap, Weimiao Yu, Hao Yin, Bogorad, Roman L., Dahlman, James E., Yee Gek Chan, Boon Huat Bay, Singaraja, Roshni, Anderson, Daniel G., Koteliansky, Victor, Viasnoff, Virgile, and Thiery, Jean Paul

Subjects
LIVER regeneration, CATENINS, LIVER disease treatment, LIVER cells, CELL communication, CELL size, CELL proliferation
Abstract

The liver is unique in its capacity to regenerate after injury, during which hepatocytes actively divide and establish cell-cell contacts through cell adhesion complexes. Here, we demonstrate that the loss of α-catenin, a well-established adhesion component, dramatically disrupts liver regeneration. Using a partial hepatectomy model, we show that regenerated livers from α-catenin knockdown mice are grossly larger than control regenerated livers, with an increase in cell size and proliferation. This increased proliferation correlated with increased YAP activation, implicating α-catenin in the Hippo/YAP pathway. Additionally, α-catenin knockdown mice exhibited a phenotype reminiscent of clinical cholestasis, with drastically altered bile canaliculi, elevated levels of bile components and signs of jaundice and inflammation. The disrupted regenerative capacity is a result of actin cytoskeletal disorganisation, leading to a loss of apical microvilli, dilated lumens in the bile canaliculi, and leaky tight junctions. This study illuminates a novel, essential role for α-catenin in liver regeneration. [ABSTRACT FROM AUTHOR]

Published
2014
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23. Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

Author

Yin, Hao, Song, Chun-Qing, Dorkin, Joseph R, Zhu, Lihua J, Li, Yingxiang, Wu, Qiongqiong, Park, Angela, Yang, Junghoon, Suresh, Sneha, Bizhanova, Aizhan, Gupta, Ankit, Bolukbasi, Mehmet F, Walsh, Stephen, Bogorad, Roman L, Gao, Guangping, Weng, Zhiping, Dong, Yizhou, Koteliansky, Victor, Wolfe, Scot A, Langer, Robert, Xue, Wen, and Anderson, Daniel G

Abstract

The combination of Cas9, guide RNA and repair template DNA can induce precise gene editing and the correction of genetic diseases in adult mammals. However, clinical implementation of this technology requires safe and effective delivery of all of these components into the nuclei of the target tissue. Here, we combine lipid nanoparticle–mediated delivery of Cas9 mRNA with adeno-associated viruses encoding a sgRNA and a repair template to induce repair of a disease gene in adult animals. We applied our delivery strategy to a mouse model of human hereditary tyrosinemia and show that the treatment generated fumarylacetoacetate hydrolase (Fah)-positive hepatocytes by correcting the causative Fah-splicing mutation. Treatment rescued disease symptoms such as weight loss and liver damage. The efficiency of correction was >6% of hepatocytes after a single application, suggesting potential utility of Cas9-based therapeutic genome editing for a range of diseases.

Published
2017
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24. Corrigendum: Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype.

Author

Yin, Hao, Xue, Wen, Chen, Sidi, Bogorad, Roman L, Benedetti, Eric, Grompe, Markus, Koteliansky, Victor, Sharp, Phillip A, Jacks, Tyler, and Anderson, Daniel G

Subjects
ANIMAL disease models, GENOMICS
Abstract

A correction to the article "Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype" published in a previous issue of 2014 is presented.

Published
2014
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