209 results on '"Bohn, Laura M."'
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2. G protein signaling–biased mu opioid receptor agonists that produce sustained G protein activation are noncompetitive agonists
3. Improved cyclobutyl nabilone analogs as potent CB1 receptor agonists
4. Pharmacological Diversity in Opioid Analgesics: Lessons From Clinically Useful Drugs
5. Structure–activity relationship investigation of triazole-based kappa opioid receptor agonists
6. Comparison of morphine, oxycodone and the biased MOR agonist SR-17018 for tolerance and efficacy in mouse models of pain
7. Comparison of Agonist Activity between CB1 and CB2 Receptors with Orthosteric Site Mutations.
8. Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures
9. Toward Directing Opioid Receptor Signaling to Refine Opioid Therapeutics
10. Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation
11. A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal
12. A Novel Method for Analyzing Extremely Biased Agonism at G Protein–Coupled Receptors
13. βArrestins: Ligand-Directed Regulators of 5-HT2A Receptor Trafficking and Signaling Events
14. Crystal Structure of the Human Cannabinoid Receptor CB2
15. Structural and functional insights into the G protein-coupled receptors: CB1 and CB2
16. A Route to Potent, Selective, and Biased Salvinorin Chemical Space
17. Bias Factor and Therapeutic Window Correlate to Predict Safer Opioid Analgesics
18. Quantitating Ligand Bias Using the Competitive Model of Ligand Activity
19. Hyperactivity in Mice Induced by Opioid Agonists with Partial Intrinsic Efficacy and Biased Agonism Administered Alone and in Combination with Morphine
20. Hyperactivity in mice induced by opioid agonists with partial intrinsic efficacy and biased agonism; alone and in combination with morphine
21. Crystal Structure of the Human Cannabinoid Receptor CB1
22. Biased agonism: An emerging paradigm in GPCR drug discovery
23. Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus
24. Characterization of kappa opioid receptor mediated, dynorphin-stimulated [35S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting
25. Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif
26. Approaches to Assess Biased Signaling at the CB1R Receptor
27. Asymmetric Syntheses of (+)- and (−)-Collybolide Enable Reevaluation of kappa-Opioid Receptor Agonism
28. Community guidelines for GPCR ligand bias:IUPHAR review 32
29. Irreversible and noncompetitive mu opioid receptor agonists
30. Advances in Sulfonamide Kappa Opioid Receptor Antagonists: Structural Refinement and Evaluation of CNS Clearance
31. Community guidelines for GPCR ligand bias: IUPHAR review 32
32. Approaches to Assess Functional Selectivity in GPCRs: Evaluating G Protein Signaling in an Endogenous Environment
33. A Genetically Encoded F-19 NMR Probe Reveals the Allosteric Modulation Mechanism of Cannabinoid Receptor 1
34. Low Intrinsic Efficacy Alone Cannot Explain the Improved Side Effect Profiles of New Opioid Agonists
35. Low Intrinsic Efficacy Alone Cannot Explain the Improved Side Effect Profiles of New Opioid Agonists.
36. Some effects of putative G-protein biased mu-opioid receptor agonists in male rhesus monkeys
37. Decaf or regular? Energizing the caffeine receptor
38. Crystal structures of agonist-bound human cannabinoid receptor CB1
39. Novel Functionalized Cannabinoid Receptor Probes: Development of Exceptionally Potent Agonists
40. Low intrinsic efficacy alone cannot explain the improved side effect profiles of new opioid agonists
41. Comparison of morphine, oxycodone and the biased MOR agonist SR-17018 for tolerance and efficacy in mouse models of pain
42. A Genetically Encoded F-19 NMR Probe Reveals the Allosteric Modulation Mechanism of Cannabinoid Receptor 1.
43. O6C-20-nor-salvinorin A is a stable and potent KOR agonist
44. Probing the CB1 Cannabinoid Receptor Binding Pocket with AM6538, a High-Affinity Irreversible Antagonist
45. A G protein signaling-biased agonist at the μ-opioid receptor reverses morphine tolerance while preventing morphine withdrawal
46. Chapter Twelve - Approaches to Assess Biased Signaling at the CB1R Receptor
47. Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists
48. The effect of quinine in two bottle choice procedures in C57BL6 mice: Opioid preference, somatic withdrawal, and pharmacokinetic outcomes
49. Optimization of a Series of Mu Opioid Receptor (MOR) Agonists with High G Protein Signaling Bias
50. Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation
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