25 results on '"Bok Joo Kim"'
Search Results
2. Is distal segment ostectomy essential for stabilization of the condylar position in patients with facial asymmetry?
- Author
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Ki Eun Hong, Eun Sup Shin, Jun Park, Ji Eon Yun, Chul Hoon Kim, Jung Han Kim, and Bok Joo Kim
- Subjects
Distal segment ostectomy ,BSSRO ,Condyle position ,Mandibular prognathism ,Dentistry ,RK1-715 ,Surgery ,RD1-811 - Abstract
Abstract Background The purpose of this retrospective study was to evaluate the postoperative change in the position and stability of the mandibular condyle after bilateral sagittal split ramus osteotomy (BSSRO) and BSSRO with distal segmental ostectomy (DSO) in patients with facial asymmetry using 3D computed tomography. Methods The condyles of the patient diagnosed with facial asymmetry were divided into the deviated side (DS) and the non-deviated side (NDS). Group I, which was treated with BSSRO only, and Group II, which additionally received DSO along with BSSRO, were superimposed on the condyle using the pre-and postoperative 3D CT. The amount of condylar change in anteroposterior displacement, mediolateral displacement, and rotation was measured. The clinical symptoms of temporomandibular joint were also evaluated before and after surgery for each patient. Results Between Groups I and II, there was no statistically significant difference in the anteroposterior condylar position on both DS and NDS. And also, there was no statistical difference between the two groups in the mediolateral change on DS but, statistically significant difference on NDS. The change in the rotation of the condyle was observed to rotate inward from both condylar heads of Groups I and II, and a statistically significant difference was observed between the two groups on both DS and NDS. Moreover, no difference in clinical temporomandibular joint symptoms was observed after surgery in each DS and NDS condyle of the two groups. Conclusions As a result of analyzing the condylar position change of the group treated with BSSRO alone and the group treated with BSSRO and DSO in patients with facial asymmetry, there were statistically significant differences in the mediolateral displacement of NDS and the condyle rotation of NDS and DS. However, the anteroposterior condylar position did not show any difference in the bilateral condyles. In addition, since worsening clinical symptoms of bilateral temporomandibular joint were not observed before and after surgery in both groups, it is concluded that it is not necessary to accompany DSO in patients with facial asymmetry (minimum 3 mm, maximum 7 mm).
- Published
- 2021
- Full Text
- View/download PDF
3. Immediate implant placement following tooth extraction with simultaneous lateral sinus augmentation: a retrospective clinical study after at least 1 year of loading
- Author
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Bok-Joo Kim, Chul-Hoon Kim, and Jung-Han Kim
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Dental implant ,Immediate placement ,Sinus augmentation ,Survival rate ,Medicine ,Dentistry ,RK1-715 - Abstract
Abstract Background Lateral sinus augmentation is necessary when the residual bone height is insufficient in the posterior maxilla. Immediate implant placement following tooth extraction with lateral sinus augmentation will shorten the number of operations and treatment time. Purpose To evaluate radiologic and clinical results for at least 1 year after loading in patients who underwent tooth extraction, implant placement, and lateral sinus augmentation at the same time. Materials and methods We retrospectively evaluated 35 implants placed in 25 patients. Preoperative and postoperative CBCT were compared and analyzed for residual bone height (RBH) and increased bone height (IBH), the initial torque value (ITV), and the implant stability quotient (ISQ). A comparative evaluation was performed between a 1-stage (non-submerged) group and a 2-stage (submerged) group. After loading for at least 1 year, clinical and radiological evaluations were performed to evaluate the survival rate. Results One of the 35 implants failed in osseointegration, and the remaining 34 showed successful results. The failure-free survival rate at 1 year was 97.06% (95% CI, 91.38-100.0%). The RBH ranged from 3.1 to 9.6 mm (mean, 5.62 ± 1.68 mm), and the IBH ranged from 3 to 15.3 mm (mean, 8.87 ± 2.74 mm). Among the RBH, ITV, ISQ, treatment period, final bone height, and failure evaluation by stage of implant placement, only ISQ showed statistical significance between the groups (p < .001). A comparison of RBH, ITV, and ISQ, regardless of group, showed that each value tended to increase, but there were no statistically significant differences. Conclusions Immediate implant placement following tooth extraction with simultaneous lateral sinus augmentation is considered reliable even though the procedures had been performed at the same time.
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- 2021
- Full Text
- View/download PDF
4. The effect of autogenous tooth bone graft material without organic matter and type I collagen treatment on bone regeneration
- Author
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Min-Gu Kim, Jung-Han Lee, Gyoo-Cheon Kim, Dae-Seok Hwang, Chul-Hun Kim, Bok-Joo Kim, Jung-Han Kim, and Uk-Kyu Kim
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Tooth bone graft material ,Type I collagen ,Autogenous graft ,Dentistry ,RK1-715 ,Surgery ,RD1-811 - Abstract
Abstract Objectives The aim of this study is to examine the effect of particulate autogenous tooth graft removed with organic matter and type I collagen addition on bone regeneration and to validate the possibility of useful allograft material for jaw defects. Material and methods Autogenous tooth bone maker (Korean Dental Solution® KOREA) made particulate autogenous tooth not including organic matter. We used to the developed tooth grafts for experiment. Cell adhesion test with hemacytometer and energy dispersive X-ray spectroscopy (Supra40 VP®, Carl Zeiss, Germany) analysis about the particulate autogenous tooth and type I collagen were performed. Rabbits were divided into three groups: bone graft with organic matter (OM) removing particulate autogenous tooth group, bone graft with OM removing particulate autogenous tooth and type I collagen group, and a control group. Bone grafting was performed in rabbit’s calvaria. The rabbits were sacrificed at different interval at 1, 2, 4, and 6 weeks after bone grafting for the histopathologic observation and observed the effect of bone regeneration by SEM, H-E & Masson stains, osteocalcin IHC staining. Result In vitro cytopathological study showed affinity for cells, cell attachment pattern, and cell proliferation in the order of control group, OM-removed and collagen-treated group, OM-removed particulate autogenous tooth group. The results of the degree of mineralization were opposite to those of the previous cell experimental results, and the OM-removed group, OM-removed group and collagen-treated group were relatively higher than the control group. Histopathologic analysis showed that vascularization and neonatal bone formation were higher in particulate autogenous tooth group with removing OM and with addition of collagen than control group and group of OM removed only. Immunohistochemical analysis showed that osteocalcin (OSC) expression was not observed in the control group, but at 4 weeks groups, OSC expression was observed the OM removed and OM-removed-collagen-treated particulate autogenous tooth, and the degree of expression was somewhat stronger in group of the OM removed and collagen additionally treated particulate autogenous tooth. Conclusion Particles that do not contain organic matter, the saint tooth, was responsible for sufficient bone graft material through the role of space maintenance and bone conduction, and further improved bone formation ability through additional collagen treatment. Therefore, research on various extracellular substrates and autologous bone grafting materials is necessary, and through this, it is possible to lay the foundation for a new type of autologous bone grafting material with excellent academic and technical utility.
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- 2021
- Full Text
- View/download PDF
5. Tenting effect of dental implant on maxillary sinus lift without grafting
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Dong-Suk Song, Chul-Hoon Kim, Bok-Joo Kim, and Jung-Han Kim
- Subjects
Dental implant ,Bone formation ,Maxillary sinus augmentation ,Sinus lift ,Dentistry ,RK1-715 - Abstract
Background/purpose: Maxillary sinus lift without grafting is an alternative procedure that is used to lower the risk of infection and facilitate the surgical procedure. The objective of this study was to evaluate the tenting effect of the dental implant by measuring the amount and morphology of bone formation around it. Material and methods: 49 implants were placed in 26 patients by maxillary sinus lift without grafting. Radiographic images were taken preoperatively and at 6 months postoperatively and used to evaluate the height of the residual bone, the width of the maxillary sinus, the amount of bone formation, and the adjacent tooth. Results: The most common type of bone formed around the implant, as seen in 23 cases, was the same height as the apex of the implant; in 11 cases, it was 0–2 mm above the apex of the implant, and in 7 cases, 2 mm or more. Meanwhile, 5 cases showed defects. The tent type of bone formation, which showed more bone formation at the implant apex than in the surrounding bone, was overwhelmingly the most common. (80.4%) The amount of bone formation increased in proportion to the difference between the residual bone height and the implant length. (P
- Published
- 2020
- Full Text
- View/download PDF
6. Positional changes of the mandibular condyle in unilateral sagittal split ramus osteotomy combined with intraoral vertical ramus osteotomy for asymmetric class III malocclusion
- Author
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Jun Park, Bok-Joo Kim, Jung-Han Kim, Eun-Sup Shin, Ji-Eon Yun, Ki-Eun Hong, and Chul-Hoon Kim
- Subjects
Orthodontics ,Sagittal split ramus osteotomy ,business.industry ,medicine.medical_treatment ,Orthognathic surgery ,Temporomandibular joint disorder ,medicine.disease ,Intraoral vertical ramus osteotomy ,Condyle ,Chin ,medicine.anatomical_structure ,stomatognathic system ,Oral and maxillofacial surgery ,medicine ,Temporomandibular Joint Disorder ,Original Article ,Surgery ,Displacement (orthopedic surgery) ,Oral Surgery ,Malocclusion ,business ,Facial asymmetry ,Facial symmetry - Abstract
Objectives In the present study, the effects of sagittal split ramus osteotomy (SSRO) combined with intraoral vertical ramus osteotomy (IVRO) for the treatment of asymmetric mandible in class Ⅲ malocclusion patients were assessed and the postoperative stability of the mandibular condyle and the symptoms of temporomandibular joint disorder (TMD) evaluated. Materials and Methods A total of 82 patients who underwent orthognathic surgery for the treatment of facial asymmetry or mandibular asymmetry at the Department of Oral and Maxillofacial Surgery, Dong-A University Hospital, from 2016 to 2021 were selected. The patients that underwent SSRO with IVRO were assigned to Group I (n=8) and patients that received bilateral SSRO (BSSRO) to Group II (n=10, simple random sampling). Preoperative and postoperative three-dimensional computed tomography (CT) axial images obtained for each group were superimposed. The condylar position changes and degree of rotation on the superimposed images were measured, and the changes in condyle based on the amount of chin movement for each surgical method were statistically analyzed. Results Group I showed a greater amount of postoperative chin movement. For the amount of mediolateral condylar displacement on the deviated side, Groups I and II showed an average lateral displacement of 0.07 mm and 1.62 mm, respectively, and statistically significantly correlated with the amount of chin movement (P=0.004). Most of the TMD symptoms in Group I patients who underwent SSRO with IVRO showed improvement. Conclusion When a large amount of mandibular rotation is required to match the menton to the midline of the face, IVRO on the deviated side is considered a technique to prevent condylar torque. In the present study, worsening of TMD symptoms did not occur after orthognathic surgery in any of the 18 patients.
- Published
- 2021
7. Parameters affecting improvement of excessive daytime sleepiness in obstructive sleep apnea patients
- Author
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Sang Hoo Park, Woo Yong Bae, Sangjun Kim, Young Gun Kim, Young Bin Yun, Hyung Geun Lee, Bok Joo Kim, and Jung-han Kim
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Sleep Apnea, Obstructive ,Cholesterol ,Otorhinolaryngology ,Polysomnography ,Humans ,Disorders of Excessive Somnolence ,Retrospective Studies - Abstract
Obstructive sleep apnea (OSA) is a sleep-related breathing disorder caused by repetitive obstruction of the upper airway; this impairs gaseous exchange, resulting in hypoxia, hypercapnia, and frequent arousals. Excessive daytime sleepiness (EDS) is a common daytime symptom of OSA. EDS manifests as fatigue and impaired attention, leading to poor performance at work and falling asleep while driving, which is a major socioeconomic problem. Therefore, it is important to properly treat EDS and accurately predict the response to treatment. However, few studies have compared OSA patients showing and not showing improvement in EDS. Therefore, this study aimed to objectively analyze and compare EDS improvement and non-improvement groups.We retrospectively reviewed the medical records of 57 OSA patients with EDS. Patients were divided into two groups according to the improvement in EDS after positive airway pressure (PAP) device treatment. We analyzed differences in clinical records including patients' age, sex, history of smoking, hypertension, diabetes, myocardial infarction, and cerebrovascular disease between the two groups. Systolic, diastolic blood pressure, blood test including blood glucose, total cholesterol, high- and low-density lipoprotein cholesterol, and triglyceride levels were also analyzed. Polysomnography (PSG) data, PAP device treatment compliance and scores of questionnaires related to various psychiatric symptoms, subjective sleep quality between the two groups were also analyzed.There was no statistically significant difference in age, gender, or past medical history between the two groups. Systolic and diastolic blood pressure, and blood test results, were also not significantly different. Among the questionnaires related to various psychiatric symptoms, the groups showed statistically significant differences in Social Avoidance and Distress Scale (SADS) and Fear of Negative Evaluation (FNE) scores (P = 0.001 and 0.020, respectively). The group differences in the scores on the other questionnaires were not significantly different. Among the PSG items, significant group differences were observed in the percentage of stage 2 non-REM sleep (N2%, P = 0.023), apnea index (AI, P = 0.005), apnea-hypopnea index (AHI, P = 0.023), and frequency of 3 % oxygen desaturation (ODI3, P = 0.001). No obesity-related parameters showed significant group differences. The percentage of days on which a PAP device was used (out of 90 days; PAP%) and percentage of days on which a PAP device was used for4 h (Time4%) did not differ significantly.The SADS, FNE, AI, AHI, N2%, and ODI3 parameters differed significantly between the EDS improvement and non-improvement groups. These parameters may help clinicians treat and predict the prognosis of patients suffering with EDS.
- Published
- 2022
8. The effect of autogenous tooth bone graft material without organic matter and type I collagen treatment on bone regeneration
- Author
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Dae-Seok Hwang, Bok-Joo Kim, Uk-Kyu Kim, Jung-Han Lee, Chul-Hun Kim, Min-Gu Kim, Jung-Han Kim, and Gyoo-Cheon Kim
- Subjects
medicine.medical_specialty ,Tooth bone graft material ,biology ,RD1-811 ,business.industry ,Research ,medicine.medical_treatment ,Dentistry ,Calvaria ,RK1-715 ,Bone grafting ,Grafting ,Staining ,Autogenous graft ,Plastic surgery ,medicine.anatomical_structure ,medicine ,Osteocalcin ,biology.protein ,Surgery ,Type I collagen ,Bone regeneration ,business - Abstract
Objectives The aim of this study is to examine the effect of particulate autogenous tooth graft removed with organic matter and type I collagen addition on bone regeneration and to validate the possibility of useful allograft material for jaw defects. Material and methods Autogenous tooth bone maker (Korean Dental Solution® KOREA) made particulate autogenous tooth not including organic matter. We used to the developed tooth grafts for experiment. Cell adhesion test with hemacytometer and energy dispersive X-ray spectroscopy (Supra40 VP®, Carl Zeiss, Germany) analysis about the particulate autogenous tooth and type I collagen were performed. Rabbits were divided into three groups: bone graft with organic matter (OM) removing particulate autogenous tooth group, bone graft with OM removing particulate autogenous tooth and type I collagen group, and a control group. Bone grafting was performed in rabbit’s calvaria. The rabbits were sacrificed at different interval at 1, 2, 4, and 6 weeks after bone grafting for the histopathologic observation and observed the effect of bone regeneration by SEM, H-E & Masson stains, osteocalcin IHC staining. Result In vitro cytopathological study showed affinity for cells, cell attachment pattern, and cell proliferation in the order of control group, OM-removed and collagen-treated group, OM-removed particulate autogenous tooth group. The results of the degree of mineralization were opposite to those of the previous cell experimental results, and the OM-removed group, OM-removed group and collagen-treated group were relatively higher than the control group. Histopathologic analysis showed that vascularization and neonatal bone formation were higher in particulate autogenous tooth group with removing OM and with addition of collagen than control group and group of OM removed only. Immunohistochemical analysis showed that osteocalcin (OSC) expression was not observed in the control group, but at 4 weeks groups, OSC expression was observed the OM removed and OM-removed-collagen-treated particulate autogenous tooth, and the degree of expression was somewhat stronger in group of the OM removed and collagen additionally treated particulate autogenous tooth. Conclusion Particles that do not contain organic matter, the saint tooth, was responsible for sufficient bone graft material through the role of space maintenance and bone conduction, and further improved bone formation ability through additional collagen treatment. Therefore, research on various extracellular substrates and autologous bone grafting materials is necessary, and through this, it is possible to lay the foundation for a new type of autologous bone grafting material with excellent academic and technical utility.
- Published
- 2021
9. Immediate reconstruction of mandibular defect after treatment of medication-related osteonecrosis of the jaw (MRONJ) with rhBMP-2/ACS and miniplate: Review of 3 cases
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Kyung-Jin Kim, Bok-Joo Kim, Chul-Hoon Kim, Mu-seong Kim, and Jung-Han Kim
- Subjects
musculoskeletal diseases ,medicine.medical_specialty ,Radiography ,medicine.medical_treatment ,Miniplate ,Article ,Collagen sponge ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Medical history ,Stage (cooking) ,Case series ,business.industry ,Mandible ,food and beverages ,Bisphosphonate ,medicine.disease ,Medication-related osteonecrosis of the jaws ,Surgery ,Sequestrectomy ,030220 oncology & carcinogenesis ,030211 gastroenterology & hepatology ,Bone morphogenic protein ,business ,Osteonecrosis of the jaw - Abstract
Highlights • The pathogenesis of MRONJ is related to repression of osteoclast mediated bone remodeling. • rhBMP-2 can stimulate not only osteoblasts but also osteoclasts and induce new bone formation. • ACS has been proved to be a good carrier of rhBMP-2 with maximal efficacy. • Application of rhBMP-2/ACS can be a new approach to surgical treatment for MRONJ patients., Introduction The purpose of this study was to pursue, and to report the results of, mandibular reconstruction and rehabilitation of medication-related osteonecrosis of the jaw (MRONJ) patients having large critical-sized defects of the mandible using a combination of recombinant human bone morphogenetic protein-2 (rhBMP-2) and absorbable collagen sponge (ACS) with surgical miniplate without any grafting materials. Case presentation Three (3) patients aged 67 and 86 (2 patients) presented due to discomfort on the mandible. They all had a medical history of bisphosphonate and steroids treatment orally or intravenously, and all had been diagnosed as MRONJ stage 3. Sequestrectomy and saucerization were performed, and then a surgical miniplate (Hansolmedical, Korea) was adapted and fixed on the sound portion of the mandible. rhBMP-2 was loaded onto an ACS at a dose of 1.5 mg/cc. Several rhBMP-2 (Cowellmedi, Korea)/ACS (Ateloplug, TRMkorea, Korea) were placed into the bony defect with a surgical miniplate. All 3 patients recovered without complications. They all exhibited radiographic evidence of bone formation by 3 months postoperatively in every case. Conclusions All 3 patients were treated successfully with rhBMP-2/ACS and miniplate without any complications. This protocol reported herein represents a new approach to the surgical treatment of maxillofacial bone defects and deficiencies, especially in MRONJ patients.
- Published
- 2020
10. Is distal segment ostectomy essential for stabilization of the condylar position in patients with facial asymmetry?
- Author
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Jung Han Kim, Bok Joo Kim, Jun Park, Eun Sup Shin, Ji Eon Yun, Ki Eun Hong, and Chul-Hoon Kim
- Subjects
Orthodontics ,BSSRO ,medicine.medical_specialty ,RD1-811 ,business.industry ,Research ,medicine.medical_treatment ,RK1-715 ,Distal segment ostectomy ,Condyle position ,Mandibular prognathism ,Condyle ,Temporomandibular joint ,Plastic surgery ,medicine.anatomical_structure ,stomatognathic system ,Dentistry ,Oral and maxillofacial surgery ,medicine ,Surgery ,In patient ,Displacement (orthopedic surgery) ,Ostectomy ,business ,Facial symmetry - Abstract
Background The purpose of this retrospective study was to evaluate the postoperative change in the position and stability of the mandibular condyle after bilateral sagittal split ramus osteotomy (BSSRO) and BSSRO with distal segmental ostectomy (DSO) in patients with facial asymmetry using 3D computed tomography. Methods The condyles of the patient diagnosed with facial asymmetry were divided into the deviated side (DS) and the non-deviated side (NDS). Group I, which was treated with BSSRO only, and Group II, which additionally received DSO along with BSSRO, were superimposed on the condyle using the pre-and postoperative 3D CT. The amount of condylar change in anteroposterior displacement, mediolateral displacement, and rotation was measured. The clinical symptoms of temporomandibular joint were also evaluated before and after surgery for each patient. Results Between Groups I and II, there was no statistically significant difference in the anteroposterior condylar position on both DS and NDS. And also, there was no statistical difference between the two groups in the mediolateral change on DS but, statistically significant difference on NDS. The change in the rotation of the condyle was observed to rotate inward from both condylar heads of Groups I and II, and a statistically significant difference was observed between the two groups on both DS and NDS. Moreover, no difference in clinical temporomandibular joint symptoms was observed after surgery in each DS and NDS condyle of the two groups. Conclusions As a result of analyzing the condylar position change of the group treated with BSSRO alone and the group treated with BSSRO and DSO in patients with facial asymmetry, there were statistically significant differences in the mediolateral displacement of NDS and the condyle rotation of NDS and DS. However, the anteroposterior condylar position did not show any difference in the bilateral condyles. In addition, since worsening clinical symptoms of bilateral temporomandibular joint were not observed before and after surgery in both groups, it is concluded that it is not necessary to accompany DSO in patients with facial asymmetry (minimum 3 mm, maximum 7 mm).
- Published
- 2021
11. Implant Placement of Severe Alveolar Bone Resorption Site with Oroantral Fistula: A Case Report
- Author
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Bok-Joo Kim, Moo-Sung Kim, Do-Hee Kim, Kuk-Won Jang, Hee-Sung Hawng, Chul-Hun Kim, and Jung-Han Kim
- Subjects
Implant placement ,business.industry ,Oroantral fistula ,Medicine ,Dentistry ,business ,Dental alveolus ,Resorption - Published
- 2018
12. Comparison of recombinant human bone morphogenetic protein-2-infused absorbable collagen sponge, recombinant human bone morphogenetic protein-2-coated tricalcium phosphate, and platelet-rich fibrin-mixed tricalcium phosphate for sinus augmentation in rabbits
- Author
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Bok-Joo Kim, Mi-Ha Ju, and Chul-Hun Kim
- Subjects
Pathology ,medicine.medical_specialty ,Maxillary sinus ,Dentistry ,02 engineering and technology ,Bone morphogenetic protein ,Bone morphogenetic protein 2 ,03 medical and health sciences ,0302 clinical medicine ,BMP-2 ,medicine ,sinus augmentation ,absorbable collagen sponge ,Bone regeneration ,General Dentistry ,Sinus (anatomy) ,Bone decalcification ,business.industry ,Chemistry ,030206 dentistry ,021001 nanoscience & nanotechnology ,medicine.disease ,Platelet-rich fibrin ,lcsh:RK1-715 ,medicine.anatomical_structure ,lcsh:Dentistry ,Original Article ,TCP ,0210 nano-technology ,business ,PRF ,Calcification - Abstract
Background/purpose: Numerous grafting materials have been used in the bone regeneration of maxillary sinus to obtain a sufficient amount of new bone in implant dentistry. The objective of this study was to compare the potentials of Type I absorbable collagen sponge (ACS) impregnated with recombinant human bone morphogenetic protein (rhBMP)-2, rhBMP-2-coated tricalcium phosphate (TCP), platelet-rich fibrin-mixed TCP for enhancing bone regeneration in sinus augmentation in rabbits. Materials and methods: The sinus defects were grafted with rhBMP-2+ACS (Group A), rhBMP-2-coated TCP (Group B), and platelet-rich fibrin-mixed TCP (Group C). The specimens underwent decalcification, and were stained for histomorphometric analysis. Results: There were no significant differences in inflammatory features among the groups 1-week postoperation. In a histomorphometric analysis, the new bone formation ratio showed significant differences between groups at 2 weeks. rhBMP-2+ACS showed a larger and more rapid bone formation area at 2 weeks than those of Groups B and C. Conclusion: Our histological evaluation demonstrates that Type I ACS can be used as a carrier of rhBMP-2, and rhBMP-2+ACS showed rapid bone formation, remodeling, and calcification at Week 2 in rabbit. Keywords: absorbable collagen sponge, BMP-2, PRF, sinus augmentation, TCP
- Published
- 2017
13. Removal of submandibular calculi by surgical method and hydraulic power with curved needle: a case report
- Author
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Bok-Joo Kim, Shi-Hyun Lee, Chul-Hoon Kim, Seong-Ho Cho, Ji-Deuk Han, Jung-Han Kim, and Ji-Bong Jo
- Subjects
Salivary gland pathology ,medicine.medical_specialty ,Salivary gland calculi ,Case Report ,Salivary function ,Surgical methods ,03 medical and health sciences ,0302 clinical medicine ,Sialolithotomy ,Hydraulic power ,Medicine ,Sialolithiasis ,030223 otorhinolaryngology ,Sialoliths ,Salivary Gland Calculus ,Submandibular gland ,business.industry ,030206 dentistry ,medicine.disease ,Surgery ,Conservative treatment ,medicine.anatomical_structure ,Oral Surgery ,business ,Duct (anatomy) - Abstract
Sialolithiasis, the most common salivary gland pathology, is caused by calculi in the gland itself and its duct. While patients with small sialoliths can undergo conservative treatment, those with standard-size or larger sialoliths require sialolithotomy. In the present case study, we removed two sialoliths located beneath the mucosa in the posterior and anterior regions of Wharton's duct, respectively. For the posterior calculus, we performed sialolithotomy via an intra-oral approach; thereafter, the small anterior calculus near the duct orifice was removed by hydraulic power. This method has not previously been reported. There were no complications either during the operation or postoperatively, and the salivary function of the gland remained normal.
- Published
- 2017
14. Tenting effect of dental implant on maxillary sinus lift without grafting
- Author
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Jung-Han Kim, Chul-Hoon Kim, Bok-Joo Kim, and Dong-Suk Song
- Subjects
Maxillary sinus ,Dental implant ,Maxillary sinus augmentation ,Radiography ,medicine.medical_treatment ,Dentistry ,Sinus lift ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,General Dentistry ,business.industry ,030206 dentistry ,Grafting ,Tenting effect ,Apex (geometry) ,lcsh:RK1-715 ,medicine.anatomical_structure ,lcsh:Dentistry ,030220 oncology & carcinogenesis ,Bone formation ,Original Article ,Implant ,business - Abstract
Background/purpose Maxillary sinus lift without grafting is an alternative procedure that is used to lower the risk of infection and facilitate the surgical procedure. The objective of this study was to evaluate the tenting effect of the dental implant by measuring the amount and morphology of bone formation around it. Material and methods 49 implants were placed in 26 patients by maxillary sinus lift without grafting. Radiographic images were taken preoperatively and at 6 months postoperatively and used to evaluate the height of the residual bone, the width of the maxillary sinus, the amount of bone formation, and the adjacent tooth. Results The most common type of bone formed around the implant, as seen in 23 cases, was the same height as the apex of the implant; in 11 cases, it was 0–2 mm above the apex of the implant, and in 7 cases, 2 mm or more. Meanwhile, 5 cases showed defects. The tent type of bone formation, which showed more bone formation at the implant apex than in the surrounding bone, was overwhelmingly the most common. (80.4%) The amount of bone formation increased in proportion to the difference between the residual bone height and the implant length. (P Conclusion The amount of bone formation in the sinus lift without grafting increased in proportion to the length of the implants in the maxillary sinus due to the tenting effect of the implant in the maxillary sinus membrane.
- Published
- 2019
15. Cytoprotective effect of flavonoid-induced autophagy on bisphosphonate mediated cell death in osteoblast
- Author
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Bok-Joo Kim, Sang-Hun Shin, Bong-Soo Park, Su-Bin Yu, Chul-Hoon Kim, Jung-Han Kim, In-Ryoung Kim, Jae-Min Song, and Hae-Mi Kang
- Subjects
0301 basic medicine ,Programmed cell death ,medicine.medical_treatment ,Biochemistry ,Bone resorption ,Metabolic bone disease ,Bone remodeling ,03 medical and health sciences ,0302 clinical medicine ,Osteogenesis ,medicine ,Autophagy ,Humans ,Molecular Biology ,Cells, Cultured ,Cell Proliferation ,Flavonoids ,Osteoblasts ,Bone Density Conservation Agents ,Cell Death ,Diphosphonates ,business.industry ,Osteoblast ,Cell Differentiation ,Cell Biology ,Bisphosphonate ,medicine.disease ,030104 developmental biology ,medicine.anatomical_structure ,Cytoprotection ,030220 oncology & carcinogenesis ,Cancer research ,Bone Remodeling ,business - Abstract
With rapid economic growth and further developments in medical science, the entry into the aging population is currently increasing, as is the number of patients with metabolic diseases, such as hypertension, hyperlipidemia, heart disease, and diabetes. The current treatments for metabolic bone diseases, which are also on the rise, cause negative side effects. Bisphosphonates, which are used to treat osteoporosis, inhibit the bone resorption ability of osteoclasts and during prolonged administration, cause bisphosphonate-related osteonecrosis of the jaw (BRONJ). Numerous studies have shown the potential role of natural plant products as flavonoids in the protection against osteoporosis and in the influence of bone remodeling. Autophagy occurs after the degradation of cytoplasmic components within the lysosome and serves as an essential cytoprotective response to pathologic stress caused by certain diseases. In the present study, we hypothesized that the cytoprotective effects of flavonoids might be related to those associated with autophagy, an essential cytoprotective response to the pathologic stress caused by certain diseases, in osteoblasts. We demonstrated the cytoprotective effect of flavonoid-induced autophagy against the toxicity of zoledronate and the induction of autophagy by flavonoids to support osteogenic transcription factors, leading to osteoblast differentiation and bone formation. Further studies are necessary to clarify the connections between autophagy and osteogenesis. It would be helpful to shed light on methodological challenges through molecular biological studies and new animal models. The findings of the current study may help to delineate the potential role of flavonoids in the treatment of metabolic bone disease.
- Published
- 2017
16. The Effects of Kaempferol-Inhibited Autophagy on Osteoclast Formation
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Bok-Joo Kim, Sang-Hun Shin, In-Ryoung Kim, Hae-Mi Kang, Bong-Soo Park, Jung-Han Kim, Chul-Hoon Kim, and Chang-Ju Kim
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0301 basic medicine ,autophagy ,Cellular differentiation ,Osteoclasts ,Apoptosis ,Article ,Catalysis ,Inorganic Chemistry ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,Western blot ,Osteogenesis ,Osteoclast ,Sequestosome-1 Protein ,medicine ,Animals ,MTT assay ,RNA, Messenger ,Bone Resorption ,Kaempferols ,Physical and Theoretical Chemistry ,Molecular Biology ,bone remodeling ,Spectroscopy ,osteoclast differentiation ,medicine.diagnostic_test ,biology ,Chemistry ,RANK Ligand ,Organic Chemistry ,Autophagy ,Acid phosphatase ,bisphosphonate-related osteonecrosis of the jaw (BRONJ) ,Cell Differentiation ,osteoporosis ,flavonoids ,General Medicine ,Computer Science Applications ,Cell biology ,RAW 264.7 Cells ,030104 developmental biology ,medicine.anatomical_structure ,Gene Expression Regulation ,Proteolysis ,biology.protein ,Kaempferol - Abstract
Kaempferol, a flavonoid compound, is derived from the rhizome of Kaempferia galanga L., which is used in traditional medicine in Asia. Autophagy has pleiotropic functions that are involved in cell growth, survival, nutrient supply under starvation, defense against pathogens, and antigen presentation. There are many studies dealing with the inhibitory effects of natural flavonoids in bone resorption. However, no studies have explained the relationship between the autophagic and inhibitory processes of osteoclastogenesis by natural flavonoids. The present study was undertaken to investigate the inhibitory effects of osteoclastogenesis through the autophagy inhibition process stimulated by kaempferol in murin macrophage (RAW 264.7) cells. The cytotoxic effect of Kaempferol was investigated by MTT assay. The osteoclast differentiation and autophagic process were confirmed via tartrate-resistant acid phosphatase (TRAP) staining, pit formation assay, western blot, and real-time PCR. Kaempferol controlled the expression of autophagy-related factors and in particular, it strongly inhibited the expression of p62/SQSTM1. In the western blot and real time-PCR analysis, when autophagy was suppressed with the application of 3-Methyladenine (3-MA) only, osteoclast and apoptosis related factors were not significantly affected. However, we found that after cells were treated with kaempferol, these factors inhibited autophagy and activated apoptosis. Therefore, we presume that kaempferol-inhibited autophagy activated apoptosis by degradation of p62/SQSTM1. Further study of the p62/SQSTM1 gene as a target in the autophagy mechanism, may help to delineate the potential role of kaempferol in the treatment of bone metabolism disorders.
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- 2018
17. Temporomandibular joint disorder from skull-base osteomyelitis: a case report
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Suck Chul Lee, Bok Joo Kim, Jae Hyung Kim, and Chul-Hoon Kim
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Osteomyelitis ,medicine.medical_treatment ,Dentistry ,Arthrocentesis ,Physical examination ,Case Report ,medicine.disease ,Condyle ,Surgery ,Otitis ,medicine.anatomical_structure ,stomatognathic system ,Skull-base osteomyelitis ,Malignant external otitis ,Arthrocentesis with lavage ,medicine ,Temporomandibular Joint Disorder ,Ear canal ,medicine.symptom ,business ,Rare disease - Abstract
Skull-base osteomyelitis is a rare disease affecting the medulla of the temporal, sphenoid, and occipital bones. In general, it occurs due to external ear canal infections caused by malignant external otitis. Skull-base osteomyelitis usually affects elderly diabetic patients. The patient, a 58-year-old man, was referred for evaluation and management of the left jaw. Clinical examination of the patient revealed pain in the left jaw and mouth-opening deflection to the left. The maximum active mouth opening was measured to about 27 mm. Panoramic, CT, and CBCT revealed bone resorption patterns in the left condyle. Through control of diabetes, continued pharmacological treatment, arthrocentesis, and occlusal stabilization appliance therapy were carried out. The extent of active mouth opening was increased to 45 mm, and pain in the left jaw joint was alleviated. This was a case wherein complications caused by failure to control diabetes induced skull-base osteomyelitis. There is a need for continued discussion about the advantages and disadvantages of arthrocentesis with lavage for patients with skull-base osteomyelitis and other treatment options.
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- 2015
18. Reconstruction of extensive jaw defects induced by keratocystic odontogenic tumor via patient-customized devices
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Bok-Joo Kim, Seok-Yong Park, Chul-Hoon Kim, and Young-Jo Shin
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medicine.medical_specialty ,Decompression ,business.industry ,Fistula ,medicine.medical_treatment ,Enucleation ,Mandible ,Case Report ,medicine.disease ,Marsupialization ,Surgery ,Maxilla ,medicine ,Keratocystic Odontogenic Tumor ,Cyst ,business - Abstract
Keratocystic odontogenic tumors can occur in any area of the maxilla or mandible. According to their size, location, and relations with surrounding structures, they are treated by cyst enucleation or enucleation after either marsupialization or decompression. Enucleation is performed when cysts are not large and when only minor damage to adjacent anatomical structures is expected. Although marsupialization and decompression follow the same basic bone-regeneration principle, which is to say, by reducing the pressure within the cyst, the former leaves a large defect after healing due to the large fistula necessary to induce the conversion of the cyst-lining epithelia to oral epithelia; the latter leaves only a relatively small defect, because of the continuous washing carried out by means of a tube inserted into a small hole in the cyst. In the latter case too, a decompressor appropriate for the focal position is required, owing to the importance of maintaining the device and controlling for oral hygiene. We report herein decompression treatment with a patient-customized device for an extensive cyst in the anterior region of the mandible.
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- 2015
19. Facial asymmetry: a case report of localized linear scleroderma patient with muscular strain and spasm
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Bok-Joo Kim, Suck-Chul Lee, Chul-Hoon Kim, and Jae-Hyung Kim
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medicine.medical_specialty ,Parry-Romberg syndrome (PRS) ,business.industry ,medicine.medical_treatment ,Orthognathic surgery ,Soft tissue ,Case Report ,medicine.disease ,Surgery ,Scleroderma ,Plastic surgery ,stomatognathic diseases ,Atrophy ,medicine ,Linear Scleroderma ,medicine.symptom ,business ,Localized Scleroderma ,Facial asymmetry ,muscle spasm ,Soft-tissue facial asymmetry ,Facial symmetry - Abstract
Facial asymmetry is found in patients with or without cosmetic facial alterations. Some patients have facial asymmetry that manifests underlying skeletal problems, while others have only limited soft-tissue facial asymmetry. Orthognathic surgery brings about a dermatic change, as soft tissue covers underlying bones. Limited soft-tissue asymmetry, meanwhile, is difficult to correct. The treatment modalities for the creation or restoration of an esthetically pleasing appearance were autogenous fat grafts, cartilage graft, and silicon injections. A young female patient had right-side facial asymmetry. The clinical assessment involved visual inspection of the face and palpation to differentiate soft tissue and bone. Although the extra-oral examination found facial asymmetry with skin atrophy, the radiographic findings revealed no mandibular atrophy or deviation. She was diagnosed as localized scleroderma with muscle spasm. In conclusion, facial asymmetry patients with skeletal asymmetry can be esthetically satisfied by orthognathic surgery; however, facial atrophy patients with skin or subdermal tissue contraction need treatment by cosmetic dermatological surgery and orthodontic correction.
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- 2015
20. Use of artificial palate for improving facial support in the fabrication of a maxillary obturator: A case report
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Bok-Joo Kim, Hee-Kyoung Yoon, Hee-Seong Hwang, Chul-Hoon Kim, and Jung-Han Kim
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Orthodontics ,03 medical and health sciences ,0302 clinical medicine ,business.industry ,Artificial palate ,0206 medical engineering ,Maxillary obturator ,Medicine ,Dentistry ,030206 dentistry ,02 engineering and technology ,business ,020601 biomedical engineering - Published
- 2017
21. Lateral approach for maxillary sinus membrane elevation without bone materials in maxillary mucous retention cyst with immediate or delayed implant rehabilitation: case reports
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Bok-Joo Kim, Seong-Gwang Kim, Seong-Ho Cho, Ji-Deuk Han, Kuk-Won Jang, Jung-Han Kim, and Chul-Hun Kim
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Sinus Floor Augmentation ,medicine.medical_specialty ,Maxillary sinus ,Sinus lift ,Dentistry ,Case Report ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Local anesthesia ,Cyst ,Sinus (anatomy) ,Cysts ,Mucous retention cyst ,business.industry ,Dental implants ,030206 dentistry ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Implant ,Oral Surgery ,business ,Without bone graft ,030217 neurology & neurosurgery ,Sinus floor augmentation - Abstract
This case series study demonstrates the possibility of successful implant rehabilitation without bone augmentation in the atrophic posterior maxilla with cystic lesion in the sinus. Sinus lift without bone graft using the lateral approach was performed. In one patient, the cyst was aspirated and simultaneous implantation under local anesthesia was performed, whereas the other cyst was removed under general anesthesia, and the sinus membrane was elevated in a second process, followed by implantation. In both cases, tapered 11.5-mm-long implants were utilized. With all of the implants, good stability and appropriate bone height were achieved. The mean bone level gain was 5.73 mm; adequate bone augmentation around the implants was shown, the sinus floor was moved apically, and the cyst was no longer radiologically detected. Completion of all of the treatments required an average of 12.5 months. The present study showed that sufficient bone formation and stable implantation in a maxilla of insufficient bone volume are possible through sinus lift without bone materials. The results serve to demonstrate, moreover, that surgical treatment of mucous retention cyst can facilitate rehabilitation. These techniques can reduce the risk of complications related to bone grafts, save money, and successfully treat antral cyst.
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- 2017
22. Full-mouth rehabilitation by immediate implantation combined with orthognathic surgery: a clinical report
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Bok-Joo Kim, Hee-Seong Hwang, Chul-Hoon Kim, Ji-Ye Heo, and Hye-Rim Ahn
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0301 basic medicine ,medicine.medical_specialty ,030102 biochemistry & molecular biology ,business.industry ,medicine.medical_treatment ,Orthognathic surgery ,Dentistry ,030206 dentistry ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Clinical report ,Full mouth rehabilitation ,medicine ,business - Published
- 2016
23. Complication rates in patients using absorbable collagen sponges in third molar extraction sockets: a retrospective study
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Bok-Joo Kim, Hoon Cho, Hwi-Dong Jung, Young-Soo Jung, and Chul-Hoon Kim
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Molar ,medicine.medical_specialty ,Tooth extraction ,business.industry ,Incidence (epidemiology) ,Dentistry ,Postoperative complication ,Retrospective cohort study ,medicine.disease ,Collagen sponge ,Surgery ,Postoperative complications ,Hematoma ,Third molar ,medicine ,Oral and maxillofacial surgery ,Original Article ,Oral Surgery ,Osteitis ,Complication ,business - Abstract
Objectives The purpose of this study is to retrospectively evaluate the postoperative complication rates for absorbable type-I collagen sponge (Ateloplug; Bioland) use in third molar extraction. Materials and methods From January to August 2013, 2,697 total patients undergoing third molar extraction and type-I collagen sponge application in the Department of Oral and Maxillofacial Surgery at Yonsei University Dental Hospital (1,163 patients) and Dong-A University Hospital (1,534 patients) were evaluated in a retrospective study using their operation and medical records. Results A total of 3,869 third molars in 2,697 patients were extracted and the extraction sockets packed with type-I collagen sponges to prevent postoperative complications. As a result, the overall complication rate was 4.52%, with 3.00% experiencing surgical site infection (SSI), 1.14% showing alveolar osteitis, and 0.39% experiencing hematoma. Of the total number of complications, SSI accounted for more than a half at 66.29%. Conclusion Compared to previous studies, this study showed a relatively low incidence of complications. The use of type-I collagen sponges is recommended for the prevention of complications after third molar extraction.
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- 2015
24. The role of kaempferol-induced autophagy on differentiation and mineralization of osteoblastic MC3T3-E1 cells.
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In-Ryoung Kim, Seong-Eon Kim, Hyun-Su Baek, Bok-Joo Kim, Chul-Hoon Kim, In-Kyo Chung, Bong-Soo Park, and Sang-Hun Shin
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AUTOPHAGY ,ALKALINE phosphatase ,ANIMAL experimentation ,BONE resorption ,ASIAN medicine ,MOLECULAR structure ,POLYMERASE chain reaction ,RABBITS ,RESEARCH funding ,STAINS & staining (Microscopy) ,STATISTICS ,WESTERN immunoblotting ,DATA analysis ,REVERSE transcriptase polymerase chain reaction ,DATA analysis software ,OSTEOBLASTS ,FLAVONOLS ,DESCRIPTIVE statistics ,IN vitro studies ,ONE-way analysis of variance - Abstract
Background: Kaempferol, a kind of flavonol, has been reported to possess various osteogenic biological activities, such as inhibiting bone resorption of osteoclasts and promoting the differentiation and mineralization of preosteoblasts. However, the precise cellular mechanism of action of kaempferol in osteogenesis is elusive. Autophagy is a major intracellular degradation system, which plays an important role in cell growth, survival, differentiation and homeostasis in mammals. Recent studies showed that autophagy appeared to be involved in the degradation of osteoclasts, osteoblasts and osteocytes, potentially pointing to a new pathogenic mechanism of bone homeostasis and bone marrow disease. The potential correlation between autophagy, osteogenesis and flavonoids is unclear. Methods: The present study verified that kaempferol promoted osteogenic differentiation and mineralization and that it elevated osteogenic gene expression based on alkaline phosphatase (ALP) activity, alizarin red staining and quantitative PCR. And then we found that kaempferol induced autophagy by acridine orange (AO) and monodansylcadaverine (MDC) staining and autophagy-related protein expression. The correlation between kaempferol-induced autophagy and the osteogenic process was confirmed by the autophagy inhibitor 3-methyladenine (3-MA). Results: Kaempferol promoted the proliferation, differentiation and mineralization of osteoblasts at a concentration of 10 µM. Kaempferol showed cytotoxic properties at concentrations above 50 µM. Concentrations above 10 µM decreased ALP activity, whereas those up to 10 µM increased ALP activity. Kaempferol at concentrations up to 10 µM also increased the expression of the osteoblast- activated factors RUNX-2, osterix, BMP-2 and collagen I according to RT-PCR analyses. 10 µM or less, the higher of the concentration and over time, kaempferol promoted the activity of osteoblasts. Kaempferol induced autophagy. It also increased the expression of the autophagy-related factors beclin-1, SQSTM1/p62 and the conversion of LC3-II from LC3-I. The application of 3-MA decreased the activity of ALP and the autophagy induced by kaempferol. In the RT-PCR analysis, the expression of RUNX-2, osterix, BMP-2 and collagen I was decreased. Conclusion: The present study showed that kaempferol stimulated the osteogenic differentiation of cultured osteoblasts by inducing autophagy. [ABSTRACT FROM AUTHOR]
- Published
- 2016
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25. Comparison of recombinant human bone morphogenetic protein-2-infused absorbable collagen sponge, recombinant human bone morphogenetic protein-2-coated tricalcium phosphate, and platelet-rich fibrin-mixed tricalcium phosphate for sinus augmentation in rabbits
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Chul-Hun Kim, Mi-Ha Ju, and Bok-Joo Kim
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Dentistry ,RK1-715 - Abstract
Background/purpose: Numerous grafting materials have been used in the bone regeneration of maxillary sinus to obtain a sufficient amount of new bone in implant dentistry. The objective of this study was to compare the potentials of Type I absorbable collagen sponge (ACS) impregnated with recombinant human bone morphogenetic protein (rhBMP)-2, rhBMP-2-coated tricalcium phosphate (TCP), platelet-rich fibrin-mixed TCP for enhancing bone regeneration in sinus augmentation in rabbits. Materials and methods: The sinus defects were grafted with rhBMP-2+ACS (Group A), rhBMP-2-coated TCP (Group B), and platelet-rich fibrin-mixed TCP (Group C). The specimens underwent decalcification, and were stained for histomorphometric analysis. Results: There were no significant differences in inflammatory features among the groups 1-week postoperation. In a histomorphometric analysis, the new bone formation ratio showed significant differences between groups at 2 weeks. rhBMP-2+ACS showed a larger and more rapid bone formation area at 2 weeks than those of Groups B and C. Conclusion: Our histological evaluation demonstrates that Type I ACS can be used as a carrier of rhBMP-2, and rhBMP-2+ACS showed rapid bone formation, remodeling, and calcification at Week 2 in rabbit. Keywords: absorbable collagen sponge, BMP-2, PRF, sinus augmentation, TCP
- Published
- 2017
- Full Text
- View/download PDF
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