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307 results on '"Bonci, Antonello"'

2. Optogenetics

Author

Michaelides, Michael, Bonci, Antonello, Pfaff, Donald W., editor, Volkow, Nora D., editor, and Rubenstein, John L., editor

Published
2022
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3. Development and use of a high-throughput screen to identify novel modulators of the corticotropin releasing factor binding protein

Author

Haass-Koffler, Carolina L., Francis, T. Chase, Gandhi, Pauravi, Patel, Reesha, Naemuddin, Mohammad, Nielsen, Carsten K., Bartlett, Selena E., Bonci, Antonello, Vasile, Stefan, Hood, Becky L., Suyama, Eigo, Hedrick, Michael P., Smith, Layton H., Limpert, Allison S., Roberto, Marisa, Cosford, Nicholas D.P., and Sheffler, Douglas J.

Published
2022
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4. High-potency ligands for DREADD imaging and activation in rodents and monkeys.

Author

Bonaventura, Jordi, Eldridge, Mark AG, Hu, Feng, Gomez, Juan L, Sanchez-Soto, Marta, Abramyan, Ara M, Lam, Sherry, Boehm, Matthew A, Ruiz, Christina, Farrell, Mitchell R, Moreno, Andrea, Galal Faress, Islam Mustafa, Andersen, Niels, Lin, John Y, Moaddel, Ruin, Morris, Patrick J, Shi, Lei, Sibley, David R, Mahler, Stephen V, Nabavi, Sadegh, Pomper, Martin G, Bonci, Antonello, Horti, Andrew G, Richmond, Barry J, and Michaelides, Michael

Subjects
Brain, Animals, Haplorhini, Humans, Rodentia, Fluorine Radioisotopes, Clozapine, Designer Drugs, Ligands, Positron-Emission Tomography, Neuronal Tract-Tracers, Neuroanatomical Tract-Tracing Techniques, HEK293 Cells, Biomedical Imaging, Neurosciences
Abstract

Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are a popular chemogenetic technology for manipulation of neuronal activity in uninstrumented awake animals with potential for human applications as well. The prototypical DREADD agonist clozapine N-oxide (CNO) lacks brain entry and converts to clozapine, making it difficult to apply in basic and translational applications. Here we report the development of two novel DREADD agonists, JHU37152 and JHU37160, and the first dedicated 18F positron emission tomography (PET) DREADD radiotracer, [18F]JHU37107. We show that JHU37152 and JHU37160 exhibit high in vivo DREADD potency. [18F]JHU37107 combined with PET allows for DREADD detection in locally-targeted neurons, and at their long-range projections, enabling noninvasive and longitudinal neuronal projection mapping.

Published
2019

8. Cooperative synaptic and intrinsic plasticity in a disynaptic limbic circuit drive stress-induced anhedonia and passive coping in mice

Author

Pignatelli, Marco, Tejeda, Hugo A., Barker, David J., Bontempi, Leonardo, Wu, Jocelyn, Lopez, Alejandra, Palma Ribeiro, Sissi, Lucantonio, Federica, Parise, Eric M., Torres-Berrio, Angélica, Alvarez-Bagnarol, Yocasta, Marino, Rosa A. M., Cai, Zhao-Lin, Xue, Mingshan, Morales, Marisela, Tamminga, Carol A., Nestler, Eric J., and Bonci, Antonello

Published
2021
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9. Cell-Type-Specific Control of Brainstem Locomotor Circuits by Basal Ganglia.

Author

Roseberry, Thomas K, Lee, A Moses, Lalive, Arnaud L, Wilbrecht, Linda, Bonci, Antonello, and Kreitzer, Anatol C

Subjects
Mesencephalon, Basal Ganglia, Neural Pathways, Neurons, Animals, Mice, Inbred C57BL, Mice, Transgenic, Mice, Brain Mapping, Motor Activity, GABAergic Neurons, Optogenetics, Neurosciences, 1.1 Normal biological development and functioning, Underpinning research, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

The basal ganglia (BG) are critical for adaptive motor control, but the circuit principles underlying their pathway-specific modulation of target regions are not well understood. Here, we dissect the mechanisms underlying BG direct and indirect pathway-mediated control of the mesencephalic locomotor region (MLR), a brainstem target of BG that is critical for locomotion. We optogenetically dissect the locomotor function of the three neurochemically distinct cell types within the MLR: glutamatergic, GABAergic, and cholinergic neurons. We find that the glutamatergic subpopulation encodes locomotor state and speed, is necessary and sufficient for locomotion, and is selectively innervated by BG. We further show activation and suppression, respectively, of MLR glutamatergic neurons by direct and indirect pathways, which is required for bidirectional control of locomotion by BG circuits. These findings provide a fundamental understanding of how BG can initiate or suppress a motor program through cell-type-specific regulation of neurons linked to specific actions.

Published
2016

13. Optogenetics: 10 years after ChR2 in neurons—views from the community

Author

Adamantidis, Antoine, Arber, Silvia, Bains, Jaideep S, Bamberg, Ernst, Bonci, Antonello, Buzsáki, György, Cardin, Jessica A, Costa, Rui M, Dan, Yang, Goda, Yukiko, Graybiel, Ann M, Häusser, Michael, Hegemann, Peter, Huguenard, John R, Insel, Thomas R, Janak, Patricia H, Johnston, Daniel, Josselyn, Sheena A, Koch, Christof, Kreitzer, Anatol C, Lüscher, Christian, Malenka, Robert C, Miesenböck, Gero, Nagel, Georg, Roska, Botond, Schnitzer, Mark J, Shenoy, Krishna V, Soltesz, Ivan, Sternson, Scott M, Tsien, Richard W, Tsien, Roger Y, Turrigiano, Gina G, Tye, Kay M, and Wilson, Rachel I

Subjects
Biomedical and Clinical Sciences, Neurosciences, Genetics, Neurological, Action Potentials, Animals, Channelrhodopsins, Humans, Neurons, Optogenetics, Psychology, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Published
2015

14. Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead

Author

Ekhtiari, Hamed, Tavakoli, Hosna, Addolorato, Giovanni, Baeken, Chris, Bonci, Antonello, Campanella, Salvatore, Castelo-Branco, Luis, Challet-Bouju, Gaëlle, Clark, Vincent P., Claus, Eric, Dannon, Pinhas N., Del Felice, Alessandra, den Uyl, Tess, Diana, Marco, di Giannantonio, Massimo, Fedota, John R., Fitzgerald, Paul, Gallimberti, Luigi, Grall-Bronnec, Marie, Herremans, Sarah C., Herrmann, Martin J., Jamil, Asif, Khedr, Eman, Kouimtsidis, Christos, Kozak, Karolina, Krupitsky, Evgeny, Lamm, Claus, Lechner, William V., Madeo, Graziella, Malmir, Nastaran, Martinotti, Giovanni, McDonald, William M., Montemitro, Chiara, Nakamura-Palacios, Ester M., Nasehi, Mohammad, Noël, Xavier, Nosratabadi, Masoud, Paulus, Martin, Pettorruso, Mauro, Pradhan, Basant, Praharaj, Samir K., Rafferty, Haley, Sahlem, Gregory, Salmeron, Betty jo, Sauvaget, Anne, Schluter, Renée S., Sergiou, Carmen, Shahbabaie, Alireza, Sheffer, Christine, Spagnolo, Primavera A., Steele, Vaughn R., Yuan, Ti-fei, van Dongen, Josanne D.M., Van Waes, Vincent, Venkatasubramanian, Ganesan, Verdejo-García, Antonio, Verveer, Ilse, Welsh, Justine W., Wesley, Michael J., Witkiewitz, Katie, Yavari, Fatemeh, Zarrindast, Mohammad-Reza, Zawertailo, Laurie, Zhang, Xiaochu, Cha, Yoon-Hee, George, Tony P., Frohlich, Flavio, Goudriaan, Anna E., Fecteau, Shirley, Daughters, Stacey B., Stein, Elliot A., Fregni, Felipe, Nitsche, Michael A., Zangen, Abraham, Bikson, Marom, and Hanlon, Colleen A.

Published
2019
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20. Optogenetics

Author

Michaelides, Michael, Bonci, Antonello, Pfaff, Donald W., editor, and Volkow, Nora D., editor

Published
2016
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23. Thorase variants are associated with defects in glutamatergic neurotransmission that can be rescued by Perampanel

Author

Umanah, George K. E., Pignatelli, Marco, Yin, Xiling, Chen, Rong, Crawford, Joshua, Neifert, Stewart, Scarffe, Leslie, Behensky, Adam A., Guiberson, Noah, Chang, Melissa, Ma, Erica, Kim, Jin Wan, Castro, Cibele C., Mao, Xiaobo, Chen, Li, Andrabi, Shaida A., Pletnikov, Mikhail V., Pulver, Ann E., Avramopoulos, Dimitrios, Bonci, Antonello, Valle, David, Dawson, Ted M., and Dawson, Valina L.

Published
2017
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29. The Interplay between Chronic Pain, Opioids, and the Immune System.

Author

Malafoglia, Valentina, Ilari, Sara, Vitiello, Laura, Tenti, Michael, Balzani, Eleonora, Muscoli, Carolina, Raffaeli, William, and Bonci, Antonello

Subjects
CHRONIC pain, OPIOID receptors, CANCER pain, OPIOID abuse, IMMUNE system, OPIOID peptides
Abstract

Chronic pain represents one of the most serious worldwide medical problems, in terms of both social and economic costs, often causing severe and intractable physical and psychological suffering. The lack of biological markers for pain, which could assist in forming clearer diagnoses and prognoses, makes chronic pain therapy particularly arduous and sometimes harmful. Opioids are used worldwide to treat chronic pain conditions, but there is still an ambiguous and inadequate understanding about their therapeutic use, mostly because of their dual effect in acutely reducing pain and inducing, at the same time, tolerance, dependence, and a risk for opioid use disorder. In addition, clinical studies suggest that opioid treatment can be associated with a high risk of immune suppression and the development of inflammatory events, worsening the chronic pain status itself. While opioid peptides and receptors are expressed in both central and peripheral nervous cells, immune cells, and tissues, the role of opioids and their receptors, when and why they are activated endogenously and what their exact role is in chronic pain pathways is still poorly understood. Thus, in this review we aim to highlight the interplay between pain and immune system, focusing on opioids and their receptors. [ABSTRACT FROM AUTHOR]

Published
2022
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34. Chronic Pain: What Does It Mean? A Review on the Use of the Term Chronic Pain in Clinical Practice

Author

Raffaeli,William, Tenti,Michael, Corraro,Annette, Malafoglia,Valentina, Ilari,Sara, Balzani,Eleonora, Bonci,Antonello, Raffaeli,William, Tenti,Michael, Corraro,Annette, Malafoglia,Valentina, Ilari,Sara, Balzani,Eleonora, and Bonci,Antonello

Abstract

William Raffaeli,1 Michael Tenti,1 Annette Corraro,2 Valentina Malafoglia,1 Sara Ilari,3 Eleonora Balzani,4 Antonello Bonci1,5 1ISAL Foundation, Institute for Research on Pain, Rimini, Italy; 2Leiden University, Faculty of Social and Behavioural Sciences, Leiden, The Netherlands; 3Institute of Research for Food Safety & Health (IRC_FSH), Department of Health Sciences, University ‘Magna Graecia’ of Catanzaro, Catanzaro, Italy; 4Department of Surgical Science, University of Turin, Torino, Italy; 5Global Institutes on Addictions, Miami, FL, USACorrespondence: William RaffaeliFondazione ISAL, Via San Salvador, 204, Rimini, 47922, ItalyTel +390541725166Fax +390541725164Email isal@fondazioneisal.itAbstract: Chronic pain is nowadays used as an umbrella term referring to a wide range of clinical conditions, such as fibromyalgia, migraine, or long-standing pain states without actual known causes. However, labeling a patient’s clinical condition with the term “chronic pain”, when dealing with pain lasting longer than 3 months, might be misleading. This paper aims at analyzing the possible pitfalls related to the use of the term “chronic pain” in the clinical field. It appears, indeed, that the term “chronic pain” shows a semantic inaccuracy on the basis of emerging scientific evidences on the pathogenesis of different long-standing pain states. The major pitfalls in using this label emerge in clinical settings, especially with patients having a biomedical perspective on pain or from different cultures, or with healthcare providers of other medical specialties or different disciplines. A label solely emphasizing temporal features does not help to discern the multifaceted complexity of long-standing pain states, whose onset, maintenance and exacerbation are influenced by a complex and interdependent set of bio-psycho-social factors. Thus, finding a more meaningful name might be imp

Published
2021

35. Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons

Author

Klawonn, Anna, Fritz, Michael, Castany Quintana, Silvia, Pignatelli, Marco, Canal, Carla, Similä, Fredrik, Tejeda, Hugo A., Levinsson, Julia, Jaarola, Maarit, Jakobsson, Johan, Hidalgo, Juan, Heilig, Markus, Bonci, Antonello, Engblom, David, Klawonn, Anna, Fritz, Michael, Castany Quintana, Silvia, Pignatelli, Marco, Canal, Carla, Similä, Fredrik, Tejeda, Hugo A., Levinsson, Julia, Jaarola, Maarit, Jakobsson, Johan, Hidalgo, Juan, Heilig, Markus, Bonci, Antonello, and Engblom, David

Abstract

Microglia are activated in many neurological diseases and have been suggested to play an important role in the development of affective disorders including major depression. To investigate how microglial signaling regulates mood, we used bidirectional chemogenetic manipulations of microglial activity in mice. Activation of microglia in the dorsal striatum induced local cytokine expression and a negative affective state characterized by anhedonia and aversion, whereas inactivation of microglia blocked aversion induced by systemic inflammation. Interleukin-6 signaling and cyclooxygenase-1 mediated prostaglandin synthesis in the microglia were critical for the inflammation-induced aversion. Correspondingly, microglial activation led to a prostaglandin-dependent reduction of the excitability of striatal neurons. These findings demonstrate a mechanism by which microglial activation causes negative affect through prostaglandin-dependent modulation of striatal neurons and indicate that interference with this mechanism could milden the depressive symptoms in somatic and psychiatric diseases involving microglial activation., Funding Agencies|Swedish Medical Research CouncilSwedish Medical Research Council (SMRC)European Commission; Knut and Alice Wallenberg FoundationKnut & Alice Wallenberg Foundation; Swedish Brain Foundation; Linkoping Parkinson Foundation; Lars Hierta Memorial Foundation; County Council of Ostergotland; [SAF2014-56546-R]; [RTI2018-101105B-I00]; [B18P0023]

Published
2021
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37. Microglial activation elicits a negative affective state through prostaglandin-mediated modulation of striatal neurons

Author

Klawonn, Anna M., primary, Fritz, Michael, additional, Castany, Silvia, additional, Pignatelli, Marco, additional, Canal, Carla, additional, Similä, Fredrik, additional, Tejeda, Hugo A., additional, Levinsson, Julia, additional, Jaarola, Maarit, additional, Jakobsson, Johan, additional, Hidalgo, Juan, additional, Heilig, Markus, additional, Bonci, Antonello, additional, and Engblom, David, additional

Published
2021
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38. VGLUT modulates sex differences in dopamine neuron vulnerability to age-related neurodegeneration

Author

Buck, Silas A., primary, Steinkellner, Thomas, additional, Aslanoglou, Despoina, additional, Villeneuve, Michael, additional, Bhatte, Sai H., additional, Childers, Victoria C., additional, Rubin, Sophie A., additional, De Miranda, Briana R., additional, O’Leary, Emma I., additional, Neureiter, Elizabeth G., additional, Fogle, Keri J., additional, Palladino, Michael J., additional, Logan, Ryan W., additional, Glausier, Jill R., additional, Fish, Kenneth N., additional, Lewis, David A., additional, Greenamyre, J. Timothy, additional, Bonci, Antonello, additional, McCabe, Brian D., additional, Cheetham, Claire E. J., additional, Hnasko, Thomas S., additional, and Freyberg, Zachary, additional

Published
2020
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41. Cooperative synaptic and intrinsic plasticity in a disynaptic limbic circuit drive stress-induced anhedonia and passive coping in mice

Author

Pignatelli, Marco, primary, Tejeda, Hugo A., additional, Barker, David J., additional, Bontempi, Leonardo, additional, Wu, Jocelyn, additional, Lopez, Alejandra, additional, Palma Ribeiro, Sissi, additional, Lucantonio, Federica, additional, Parise, Eric M., additional, Torres-Berrio, Angélica, additional, Alvarez-Bagnarol, Yocasta, additional, Marino, Rosa A. M., additional, Cai, Zhao-Lin, additional, Xue, Mingshan, additional, Morales, Marisela, additional, Tamminga, Carol A., additional, Nestler, Eric J., additional, and Bonci, Antonello, additional

Published
2020
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43. Identification of MOR-Positive B Cell as Possible Innovative Biomarker (Mu Lympho-Marker) for Chronic Pain Diagnosis in Patients with Fibromyalgia and Osteoarthritis Diseases

Author

Raffaeli, William, primary, Malafoglia, Valentina, additional, Bonci, Antonello, additional, Tenti, Michael, additional, Ilari, Sara, additional, Gremigni, Paola, additional, Iannuccelli, Cristina, additional, Gioia, Chiara, additional, Di Franco, Manuela, additional, Mollace, Vincenzo, additional, Vitiello, Laura, additional, Tomino, Carlo, additional, and Muscoli, Carolina, additional

Published
2020
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44. Transcranial electrical and magnetic stimulation (tES and TMS) for addiction medicine: A consensus paper on the present state of the science and the road ahead

Author

Ekhtiari, H., Tavakoli, H., Addolorato, Giovanni, Baeken, C., Bonci, Antonello, Campanella, Salvatore, Castelo-Branco, L., Challet-Bouju, G., Clark, V. P., Claus, E., Dannon, P. N., Del Felice, A., den Uyl, T., Diana, Maria Letizia, Di Giannantonio, Massimo, Fedota, J. R., Fitzgerald, P., Gallimberti, L., Grall-Bronnec, M., Herremans, S. C., Herrmann, M. J., Jamil, A., Khedr, E., Kouimtsidis, C., Kozak, K., Krupitsky, E., Lamm, C., Lechner, W. V., Madeo, G., Malmir, N., Martinotti, Giovanni, Mcdonald, W. M., Montemitro, C., Nakamura-Palacios, E. M., Nasehi, M., Noel, X., Nosratabadi, M., Paulus, M., Pettorruso, Mauro, Pradhan, B., Praharaj, S. K., Rafferty, H., Sahlem, G., Salmeron, B. J., Sauvaget, A., Schluter, R. S., Sergiou, C., Shahbabaie, A., Sheffer, C., Spagnolo, P. A., Steele, V. R., Yuan, T. -F., van Dongen, J. D. M., Van Waes, V., Venkatasubramanian, G., Verdejo-Garcia, A., Verveer, I., Welsh, J. W., Wesley, M. J., Witkiewitz, K., Yavari, F., Zarrindast, M. -R., Zawertailo, L., Zhang, X., Cha, Y. -H., George, T. P., Frohlich, F., Goudriaan, A. E., Fecteau, S., Daughters, S. B., Stein, E. A., Fregni, F., Nitsche, M. A., Zangen, A., Bikson, M., Hanlon, C. A., Addolorato G. (ORCID:0000-0002-1522-9946), Bonci A., Campanella S., Diana M., di Giannantonio M., Martinotti G., Pettorruso M., Ekhtiari, H., Tavakoli, H., Addolorato, Giovanni, Baeken, C., Bonci, Antonello, Campanella, Salvatore, Castelo-Branco, L., Challet-Bouju, G., Clark, V. P., Claus, E., Dannon, P. N., Del Felice, A., den Uyl, T., Diana, Maria Letizia, Di Giannantonio, Massimo, Fedota, J. R., Fitzgerald, P., Gallimberti, L., Grall-Bronnec, M., Herremans, S. C., Herrmann, M. J., Jamil, A., Khedr, E., Kouimtsidis, C., Kozak, K., Krupitsky, E., Lamm, C., Lechner, W. V., Madeo, G., Malmir, N., Martinotti, Giovanni, Mcdonald, W. M., Montemitro, C., Nakamura-Palacios, E. M., Nasehi, M., Noel, X., Nosratabadi, M., Paulus, M., Pettorruso, Mauro, Pradhan, B., Praharaj, S. K., Rafferty, H., Sahlem, G., Salmeron, B. J., Sauvaget, A., Schluter, R. S., Sergiou, C., Shahbabaie, A., Sheffer, C., Spagnolo, P. A., Steele, V. R., Yuan, T. -F., van Dongen, J. D. M., Van Waes, V., Venkatasubramanian, G., Verdejo-Garcia, A., Verveer, I., Welsh, J. W., Wesley, M. J., Witkiewitz, K., Yavari, F., Zarrindast, M. -R., Zawertailo, L., Zhang, X., Cha, Y. -H., George, T. P., Frohlich, F., Goudriaan, A. E., Fecteau, S., Daughters, S. B., Stein, E. A., Fregni, F., Nitsche, M. A., Zangen, A., Bikson, M., Hanlon, C. A., Addolorato G. (ORCID:0000-0002-1522-9946), Bonci A., Campanella S., Diana M., di Giannantonio M., Martinotti G., and Pettorruso M.

Abstract

There is growing interest in non-invasive brain stimulation (NIBS) as a novel treatment option for substance-use disorders (SUDs). Recent momentum stems from a foundation of preclinical neuroscience demonstrating links between neural circuits and drug consuming behavior, as well as recent FDA-approval of NIBS treatments for mental health disorders that share overlapping pathology with SUDs. As with any emerging field, enthusiasm must be tempered by reason; lessons learned from the past should be prudently applied to future therapies. Here, an international ensemble of experts provides an overview of the state of transcranial-electrical (tES) and transcranial-magnetic (TMS) stimulation applied in SUDs. This consensus paper provides a systematic literature review on published data – emphasizing the heterogeneity of methods and outcome measures while suggesting strategies to help bridge knowledge gaps. The goal of this effort is to provide the community with guidelines for best practices in tES/TMS SUD research. We hope this will accelerate the speed at which the community translates basic neuroscience into advanced neuromodulation tools for clinical practice in addiction medicine.

Published
2019

46. Astrocyte redox dysregulation causes prefrontal hypoactivity: sulforaphane treats non-ictal pathophysiology in ALDH7A1-mediated epilepsy

Author

Faust, Travis E., primary, Xin, Wendy, additional, Lee, Brian, additional, Agarwal, Amit, additional, Saha, Sneha, additional, Palen, Trexy, additional, Cash-Padgett, Tyler, additional, Wood, Daniel, additional, Bonci, Antonello, additional, Fahey, Jed W., additional, Jaaro-Peled, Hanna, additional, Bergles, Dwight E., additional, and Sawa, Akira, additional

Published
2019
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