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Your search keyword '"Borowczyk, Julia"' showing total 16 results
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16 results on '"Borowczyk, Julia"'

11. Keratinocyte-specific ablation of Mcpip1 impairs skin integrity and promotes local and systemic inflammation

Author

Konieczny, Piotr, primary, Lichawska-Cieslar, Agata, additional, Kwiecinska, Patrycja, additional, Cichy, Joanna, additional, Pietrzycka, Roza, additional, Szukala, Weronika, additional, Declercq, Wim, additional, Devos, Michael, additional, Paziewska, Agnieszka, additional, Rumienczyk, Izabela, additional, Kulecka, Maria, additional, Mikula, Michal, additional, Fu, Mingui, additional, Borowczyk, Julia, additional, Santamaria-Babí, Luis F, additional, and Jura, Jolanta, additional

Published
2019
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13. Effect of silver nanoparticles on human primary keratinocytes

Author

Szmyd, Radoslaw, primary, Goralczyk, Anna Grazyna, additional, Skalniak, Lukasz, additional, Cierniak, Agnieszka, additional, Lipert, Barbara, additional, Filon, Francesca Larese, additional, Crosera, Matteo, additional, Borowczyk, Julia, additional, Laczna, Eliza, additional, Drukala, Justyna, additional, Klein, Andrzej, additional, and Jura, Jolanta, additional

Published
2016
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14. Fenofibrate enhances barrier function of endothelial continuum within the metastatic niche of prostate cancer cells

Author

Piwowarczyk, Katarzyna, primary, Wybieralska, Ewa, additional, Baran, Jarosław, additional, Borowczyk, Julia, additional, Rybak, Paulina, additional, Kosińska, Milena, additional, Włodarczyk, Anna Julia, additional, Michalik, Marta, additional, Siedlar, Maciej, additional, Madeja, Zbigniew, additional, Dobrucki, Jerzy, additional, Reiss, Krzysztof, additional, and Czyż, Jarosław, additional

Published
2014
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15. Fenofibrate enhances barrier function of endothelial continuum within the metastatic niche of prostate cancer cells

Author

Piwowarczyk, Katarzyna, Wybieralska, Ewa, Baran, Jarosaw, Borowczyk, Julia, Rybak, Paulina, Kosiska, Milena, Wodarczyk, Anna Julia, Michalik, Marta, Siedlar, Maciej, Madeja, Zbigniew, Dobrucki, Jerzy, Reiss, Krzysztof, and Czy, Jarosaw

Abstract

Objective:Extravasation of circulating cancer cells is an important step of the metastatic cascade and a potential target for anti-cancer strategies based on vasoprotective drugs. Reports on anti-cancer effects of fenofibrate (FF) prompted us to analyze its influence on the endothelial barrier function during prostate cancer cell diapedesis.Research design and methods:In vitroco-cultures of endothelial cells with cancer cells imitate the ‘metastatic niche’ in vivo.We qualitatively and quantitatively estimated the effect of 25 μM FF on the events which accompany prostate carcinoma cell diapedesis, with the special emphasis on endothelial cell mobilization.Results:Fenofibrate attenuated cancer cell diapedesis via augmenting endothelial cell adhesion to the substratum rather than through the effect on intercellular communication networks within the metastatic niche. The inhibition of endothelial cell motility was accompanied by the activation of PPARα-dependent and PPARα-independent reactive oxygen species signaling, Akt and focal adhesion kinase (FAK) phosphorylation, in the absence of cytotoxic effects in endothelial cells.Conclusions:Fenofibrate reduces endothelial cell susceptibility to the paracrine signals received from prostate carcinoma cells, thus inhibiting endothelial cell mobilization and reducing paracellular permeability of endothelium in the metastatic niche. Our data provide a mechanistic rationale for extending the clinical use of FF and for the combination of this well tolerated vasoactive drug with the existing multidrug regimens used in prostate cancer therapy.

Published
2015
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16. A methylome and transcriptome analysis of normal human scar cells reveals a role for FOXF2in scar maintenance

Author

Stevenson, Andrew W., Melton, Phillip E., Moses, Eric.K., Wallace, Hilary J., Wood, Fiona M., Rea, Suzanne, Danielsen, Patricia L., Alghamdi, Mansour, Hortin, Nicole, Borowczyk, Julia, Deng, Zhenjun, Manzur, Mitali, and Fear, Mark W.

Abstract

Scar is maintained for life and increases in size during periods of growth such as puberty. Epigenetic changes in fibroblasts after injury may underpin the maintenance and growth of scar. Here, we, combined methylome and transcriptome data from normotrophic mature scar and contralateral uninjured normal skin fibroblasts to identify potential regulators of scar maintenance. 219 significantly differentially expressed and 1199 significantly differentially methylated promoters were identified, of which there were 12 genes both significantly differentially methylated and expressed. Of these the two transcription factors, Forkhead Box F2 (FOXF2) and Mohawk Homeobox (MKX) were selected for further analysis. Immunocytochemistry and qPCR suggested FOXF2 but not MKX had elevated expression in scar fibroblasts. Using RNASeq, FOXF2knockdown was shown to significantly reduce expression of extracellular matrix related genes, whilst MKXdid not appear to affect similar pathways. Finally, FOXF2knockdown was also shown to significantly decrease collagen I production in scar and keloid fibroblasts. This study provides insights into the maintenance of normotrophic scar, suggesting FOXF2is an important regulator of this process. Targeting genes responsible for maintenance of scar phenotype may ameliorate scar appearance and improve patient outcomes in the future.

Published
2021
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