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151 results on '"Bouffler, Simon"'

2. Radiation Adverse Outcome pathways (AOPs): examining priority questions from an international horizon-style exercise

Author

Chauhan, Vinita, primary, Beaton, Danielle, additional, Tollefsen, Knut Erik, additional, Preston, Julian, additional, Burtt, Julie J., additional, Leblanc, Julie, additional, Hamada, Nobuyuki, additional, Azzam, Edouard I., additional, Armant, Olivier, additional, Bouffler, Simon, additional, Azimzadeh, Omid, additional, Moertl, Simone, additional, Yamada, Yutaka, additional, Tanaka, Ignacia B., additional, Kaiser, Jan Christian, additional, Applegate, Kimberly, additional, Laurier, Dominique, additional, and Garnier-Laplace, Jacqueline, additional

Published
2024
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4. Radiotherapy for non-cancer diseases: benefits and long-term risks.

Author

Thariat, Juliette, Little, Mark P., Zablotska, Lydia B., Samson, Pamela, O'Banion, M. Kerry, Leuraud, Klervi, Bergom, Carmen, Girault, Gilles, Azimzadeh, Omid, Bouffler, Simon, and Hamada, Nobuyuki

Subjects
VENTRICULAR tachycardia, COVID-19, ALZHEIMER'S disease, OSTEOARTHRITIS, RADIOTHERAPY
Abstract

The discovery of X-rays was followed by a variety of attempts to treat infectious diseases and various other non-cancer diseases with ionizing radiation, in addition to cancer. There has been a recent resurgence of interest in the use of such radiotherapy for non-cancer diseases. Non-cancer diseases for which use of radiotherapy has currently been proposed include refractory ventricular tachycardia, neurodegenerative diseases (e.g. Alzheimer's disease and dementia), and Coronavirus Disease 2019 (COVID-19) pneumonia, all with ongoing clinical studies that deliver radiation doses of 0.5–25 Gy in a single fraction or in multiple daily fractions. In addition to such non-cancer effects, historical indications predominantly used in some countries (e.g. Germany) include osteoarthritis and degenerative diseases of the bones and joints. This narrative review gives an overview of the biological rationale and ongoing preclinical and clinical studies for radiotherapy proposed for various non-cancer diseases, discusses the plausibility of the proposed biological rationale, and considers the long-term radiation risks of cancer and non-cancer diseases. A growing body of evidence has suggested that radiation represents a double-edged sword, not only for cancer, but also for non-cancer diseases. At present, clinical evidence has shown some beneficial effects of radiotherapy for ventricular tachycardia, but there is little or no such evidence of radiotherapy for other newly proposed non-cancer diseases (e.g. Alzheimer's disease, COVID-19 pneumonia). Patients with ventricular tachycardia and COVID-19 pneumonia have thus far been treated with radiotherapy when they are an urgent life threat with no efficient alternative treatment, but some survivors may encounter a paradoxical situation where patients were rescued by radiotherapy but then get harmed by radiotherapy. Further studies are needed to justify the clinical use of radiotherapy for non-cancer diseases, and optimize dose to diseased tissue while minimizing dose to healthy tissue. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Statistical Integration of p-values for Enhancing Discovery of Radiotoxicity Gene Signatures

Author

Papiez, Anna, Kabacik, Sylwia, Badie, Christophe, Bouffler, Simon, Polanska, Joanna, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Kobsa, Alfred, Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Nierstrasz, Oscar, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Istrail, Sorin, Series editor, Pevzner, Pavel, Series editor, Waterman, Michael S., Series editor, Ortuño, Francisco, editor, and Rojas, Ignacio, editor

Published
2015
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10. THE DOSE AND DOSE-RATE EFFECTIVENESS FACTOR (DDREF)

Author

Wakeford, Richard, Azizova, Tamara, Dörr, Wolfgang, Garnier-Laplace, Jacqueline, Hauptmann, Michael, Ozasa, Kotaro, Rajaraman, Preetha, Sakai, Kazuo, Salomaa, Sisko, Sokolnikov, Mikhail, Stram, Dan, Sun, Quanfu, Wojcik, Andrzej, Woloschak, Gayle, Bouffler, Simon, Grosche, Bernd, Kai, Michiaki, Little, Mark P., Shore, Roy E., Walsh, Linda, and Rühm, Werner

Published
2019
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12. Radiation adverse outcome pathways (AOPs) are on the horizon: advancing radiation protection through an international Horizon-Style exercise

Author

Burtt, Julie J., primary, Leblanc, Julie, additional, Randhawa, Kristi, additional, Ivanova, Addie, additional, Rudd, Murray A., additional, Wilkins, Ruth, additional, Azzam, Edouard I., additional, Hecker, Markus, additional, Horemans, Nele, additional, Vandenhove, Hildegarde, additional, Adam-Guillermin, Christelle, additional, Armant, Olivier, additional, Klokov, Dmitry, additional, Audouze, Karine, additional, Kaiser, Jan Christian, additional, Moertl, Simone, additional, Lumniczky, Katalin, additional, Tanaka, Ignacia B., additional, Yamada, Yutaka, additional, Hamada, Nobuyuki, additional, Al-Nabulsi, Isaf, additional, Preston, R. Julian, additional, Bouffler, Simon, additional, Applegate, Kimberly, additional, Cool, Donald, additional, Beaton, Danielle, additional, Tollefsen, Knut Erik, additional, Garnier-Laplace, Jacqueline, additional, Laurier, Dominique, additional, and Chauhan, Vinita, additional

Published
2022
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16. Potential risks associated with the use of ionizing radiation for imaging and treatment of colorectal cancer in Lynch syndrome patients

Author

Sun, Mingzhu, primary, Moquet, Jayne, additional, Ellender, Michele, additional, Bouffler, Simon, additional, Badie, Christophe, additional, Baldwin-Cleland, Rachel, additional, Monahan, Kevin, additional, Latchford, Andrew, additional, Lloyd, David, additional, Clark, Susan, additional, Anyamene, Nicola A., additional, Ainsbury, Elizabeth, additional, and Burling, David, additional

Published
2022
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18. Funding for radiation research: past, present and future

Author

Cho, Kunwoo, Imaoka, Tatsuhiko, Klokov, Dmitry, Paunesku, Tatjana, Salomaa, Sisko, Birschwilks, Mandy, Bouffler, Simon, L. Brooks, Antone, K. Hei, Tom, Iwasaki, Toshiyasu, Ono, Tetsuya, Sakai, Kazuo, Wojcik, Andrzej, E. Woloschak, Gayle, Yamada, Yutaka, and Hamada, Nobuyuki

Abstract

Purpose: For more than a century, ionizing radiation has been indispensable mainly in medicine and industry. Radiation research is a multidisciplinary field that investigates radiation effects. Radiation research was very active in the mid- to late 20th century, but has then faced challenges, during which time funding has fluctuated widely. Here we review historical changes in funding situations in the field of radiation research, particularly in Canada, European Union countries, Japan, South Korea, and the US. We also provide a brief overview of the current situations in education and training in this field. Conclusions: A better understanding of the biological consequences of radiation exposure is becoming more important with increasing public concerns on radiation risks and other radiation literacy. Continued funding for radiation research is needed, and education and training in this field are also important.

Published
2019

21. Assessing radiation risk perception by means of a European stakeholder survey

Author

Della Monaca, Sara, primary, Dini, Valentina, additional, Grande, Sveva, additional, Palma, Alessandra, additional, Tkaczyk, Alan H, additional, Koch, Rein, additional, Murakas, Rein, additional, Perko, Tanja, additional, Duranova, Tatiana, additional, Salomaa, Sisko, additional, Roivainen, Päivi, additional, Willrodt, Christine, additional, Grigioni, Mauro, additional, and Bouffler, Simon, additional

Published
2021
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28. Adverse outcome pathways, key events, and radiation risk assessment.

Author

Preston, R. Julian, Rühm, Werner, Azzam, Edouard I., Boice, John D., Bouffler, Simon, Held, Kathryn D., Little, Mark P., Shore, Roy E., Shuryak, Igor, and Weil, Michael M.

Subjects
RADIATION carcinogenesis, HEALTH risk assessment, RADIOBIOLOGY, RISK assessment, RADIATION protection, RADIATION
Abstract

The overall aim of this contribution to the 'Second Bill Morgan Memorial Special Issue' is to provide a high-level review of a recent report developed by a Committee for the National Council on Radiation Protection and Measurements (NCRP) titled 'Approaches for Integrating Information from Radiation Biology and Epidemiology to Enhance Low-Dose Health Risk Assessment'. It derives from previous NCRP Reports and Commentaries that provide the case for integrating data from radiation biology studies (available and proposed) with epidemiological studies (also available and proposed) to develop Biologically-Based Dose-Response (BBDR) models. In this review, it is proposed for such models to leverage the adverse outcome pathways (AOP) and key events (KE) approach for better characterizing radiation-induced cancers and circulatory disease (as the example for a noncancer outcome). The review discusses the current state of knowledge of mechanisms of carcinogenesis, with an emphasis on radiation-induced cancers, and a similar discussion for circulatory disease. The types of the various informative BBDR models are presented along with a proposed generalized BBDR model for cancer and a more speculative one for circulatory disease. The way forward is presented in a comprehensive discussion of the research needs to address the goal of enhancing health risk assessment of exposures to low doses of radiation. The use of an AOP/KE approach for developing a mechanistic framework for BBDR models of radiation- induced cancer and circulatory disease is considered to be a viable one based upon current knowledge of the mechanisms of formation of these adverse health outcomes and the available technical capabilities and computational advances. The way forward for enhancing low-dose radiation risk estimates will require there to be a tight integration of epidemiology data and radiation biology information to meet the goals of relevance and sensitivity of the adverse health outcomes required for overall health risk assessment at low doses and dose rates. [ABSTRACT FROM AUTHOR]

Published
2021
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33. 343. A public facing survey on radiation risk perception set up within the CONCERT European Joint Programme: preliminary results

Author

Grande, Sveva, primary, Monaca, Sara Della, additional, Dini, Valentina, additional, Palma, Alessandra, additional, Fattibene, Paola, additional, Rosi, Antonella, additional, Tabocchini, Maria Antonella, additional, Duranova, Tatiana, additional, Perko, Tanja, additional, Pölzl-Viol, Christiane, additional, Tomkiv, Yevgeniya, additional, Turcanu, Catrinel, additional, Willrodt, Christine, additional, Grigioni, Mauro, additional, and Bouffler, Simon, additional

Published
2018
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45. Nonlinear ionizing radiation-induced changes in eye lens cell proliferation, cyclin D1 expression and lens shape

Author

Markiewicz, Ewa, Barnard, Stephen, Haines, Jackie, Coster, Margaret, van Geel, Orry, Wu, Weiju, Richards, Shane, Ainsbury, Elizabeth, Rothkamm, Kai, Bouffler, Simon, and Quinlan, Roy A.

Subjects
Male, Ionizing radiation, DNA Repair, Immunoblotting, cyclin D1, Models, Biological, Cell Line, Histones, Lens, Crystalline, Animals, Humans, DNA Breaks, Double-Stranded, Cyclin D1, Lymphocytes, γH2AX, Non-linear effect, lcsh:QH301-705.5, Cell Shape, Cell Proliferation, gH2AX, Research, X-Rays, Dose-Response Relationship, Radiation, Epithelial Cells, Mice, Inbred C57BL, lcsh:Biology (General), Microscopy, Fluorescence, Eye lens, DNA DSB, non-linear effect, Female, ionizing radiation, eye lens, Algorithms, Research Article
Abstract

Elevated cataract risk after radiation exposure was established soon after the discovery of X-rays in 1895. Today, increased cataract incidence among medical imaging practitioners and after nuclear incidents has highlighted how little is still understood about the biological responses of the lens to low-dose ionizing radiation (IR). Here, we show for the first time that in mice, lens epithelial cells (LECs) in the peripheral region repair DNA double strand breaks (DSB) after exposure to 20 and 100 mGy more slowly compared with circulating blood lymphocytes, as demonstrated by counts of γH2AX foci in cell nuclei. LECs in the central region repaired DSBs faster than either LECs in the lens periphery or lymphocytes. Although DSB markers (γH2AX, 53BP1 and RAD51) in both lens regions showed linear dose responses at the 1 h timepoint, nonlinear responses were observed in lenses for EdU (5-ethynyl-2′-deoxy-uridine) incorporation, cyclin D1 staining and cell density after 24 h at 100 and 250 mGy. After 10 months, the lens aspect ratio was also altered, an indicator of the consequences of the altered cell proliferation and cell density changes. A best-fit model demonstrated a dose-response peak at 500 mGy. These data identify specific nonlinear biological responses to low (less than 1000 mGy) dose IR-induced DNA damage in the lens epithelium.

Published
2015

46. Transcriptomic and proteomic analysis of mouse radiation-induced acute myeloid leukaemia (AML)

Author

Badie, Christophe, primary, Blachowicz, Agnieszka, additional, Barjaktarovic, Zarko, additional, Finnon, Rosemary, additional, Michaux, Arlette, additional, Sarioglu, Hakan, additional, Brown, Natalie, additional, Manning, Grainne, additional, Benotmane, M. Abderrafi, additional, Tapio, Soile, additional, Polanska, Joanna, additional, and Bouffler, Simon D., additional

Published
2016
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49. Genotoxic effects of high dose rate X-ray and low dose rate gamma radiation in ApcMin/+ mice.

Author

Graupner, Anne, Eide, Dag M., Brede, Dag A., Ellender, Michele, Lindbo Hansen, Elisabeth, Oughton, Deborah H., Bouffler, Simon D., Brunborg, Gunnar, and Olsen, Ann Karin

Subjects
GAMMA rays, IONIZING radiation, HIGH dynamic range imaging, COLON cancer, FLOW cytometry
Abstract

Risk estimates for radiation-induced cancer in humans are based on epidemiological data largely drawn from the Japanese atomic bomb survivor studies, which received an acute high dose rate (HDR) ionising radiation. Limited knowledge exists about the effects of chronic low dose rate (LDR) exposure, particularly with respect to the application of the dose and dose rate effectiveness factor. As part of a study to investigate the development of colon cancer following chronic LDR vs. acute HDR radiation, this study presents the results of genotoxic effects in blood of exposed mice. CBAB6 F1 Apc+/+ (wild type) and ApcMin/+ mice were chronically exposed to estimated whole body absorbed doses of 1.7 or 3.2 Gy 60Co-γ-rays at a LDR (2.2 mGy h−1) or acutely exposed to 2.6 Gy HDR X-rays (1.3 Gy min−1). Genotoxic endpoints assessed in blood included chromosomal damage (flow cytometry based micronuclei (MN) assay), mutation analyses ( Pig-a gene mutation assay), and levels of DNA lesions (Comet assay, single-strand breaks (ssb), alkali labile sites (als), oxidized DNA bases). Ionising radiation (ca. 3 Gy) induced genotoxic effects dependent on the dose rate. Chromosomal aberrations (MN assay) increased 3- and 10-fold after chronic LDR and acute HDR, respectively. Phenotypic mutation frequencies as well as DNA lesions (ssb/als) were modulated after acute HDR but not after chronic LDR. The ApcMin/+ genotype did not influence the outcome in any of the investigated endpoints. The results herein will add to the scant data available on genotoxic effects following chronic LDR of ionising radiation. Environ. Mol. Mutagen. 58:560-569, 2017. © 2017 The Authors Environmental and Molecular Mutagenesis published by Wiley Periodicals, Inc. on behalf of Environmental Mutagen Society [ABSTRACT FROM AUTHOR]

Published
2017
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