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4. Documenting the Recovery of Vascular Services in European Centres Following the Initial COVID-19 Pandemic Peak: Results from a Multicentre Collaborative Study

Author

collaborative, The VERN COVER study, Ruffino, Maria Antonella, Chan, Sharon, Coughlin, Patrick, Awopetu, Ayoola, Stather, Philip, Lane, Tristan, Theodosiou, Dimitrios, Ahmed, Mohamed Abozeid, Vasudevan, Thodur, Ibrahim, Mohammed, Maadany, Faraj Al, Eljareh, Mohamed, Alkhafeefi, Fatimah Saad, Coscas, Raphael, Ünal, Ertekin Utku, Pulli, Raffaele, Zacà, Sergio, Angiletta, Domenico, Kotsis, Thomas, Moawad, Magdy, Tozzi, Matteo, Patelis, Nikolaos, Lazaris, Andreas M, Chuen, Jason, Croo, Alexander, Tsolaki, Elpiniki, Zenunaj, Gladiol, Kamal, Dhafer, Tolba, Mahmoud MH, Maresch, Martin, Khetarpaul, Vipul, Mills, Joseph, Gangwani, Gaurav, Elahwal, Mohamed, Khalil, Rana, Azab, Mohammed A, Mahomed, Anver, Whiston, Richard, Contractor, Ummul, Esposito, Davide, Pratesi, Carlo, Giacomelli, Elena, Troncoso, Martín Veras, Elkouri, Stephane, Johansson, Flavia Gentile, Dodos, Ilias, Benezit, Marie, Vidoedo, José, Rocha-Neves, João, Pereira-Neves, António Henrique, Dias-Neto, Marina Felicidade, Jácome, Ana Filipa Campos, Loureiro, Luis, Silva, Ivone, Garza-Herrera, Rodrigo, Canata, Victor, Bezard, Charlotte, Bowser, Kathryn, Tobar, Jorge Felipe, Vera, Carlos Gomez, Parra, Carolina Salinas, Lopez, Eugenia, Serra, Yvis Gadelha, Varela, Juan, Rubio, Vanessa, Victoria, Gerardo, Johnson, Adam, O’Banion, Leigh Ann, Makar, Ragai, Tantawy, Tamer Ghatwary, Storck, Martin, Jongkind, Vincent, falah, Orwa, McBride, Olivia, Isik, Arda, Papaioannou, Athanasios, Reis, Paulo Eduardo Ocke, Bracale, Umberto Marcello, Atkins, Ellie, Tinelli, Giovanni, Scott, Emma, Wales, Lucy, Sivaharan, Ashwin, Priona, Georgia, Nesbitt, Craig, Grainger, Tabitha, Shelmerdine, Lauren, Chong, Patrick, Bajwa, Adnan, Arwynck, Luke, Hadjievangelou, Nancy, Elbasty, Ahmed, Rubio, Oscar, Ricardo, Michael, Ulloa, Jorge H, Tarazona, Marcos, Pabon, Manuel, Pitoulias, Georgios, and Corless, Kevin

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Dentistry, Pediatric Research Initiative, Prevention, 6.4 Surgery, Evaluation of treatments and therapeutic interventions, VERN COVER study collaborative, AAA, COVID-19, PAD, Survey, Vascular surgery, Cardiovascular medicine and haematology, Clinical sciences
Abstract

ObjectiveTo document the recovery of vascular services in Europe following the first COVID-19 pandemic peak.MethodsAn online structured vascular service survey with repeated data entry between 23 March and 9 August 2020 was carried out. Unit level data were collected using repeated questionnaires addressing modifications to vascular services during the first peak (March - May 2020, "period 1"), and then again between May and June ("period 2") and June and July 2020 ("period 3"). The duration of each period was similar. From 2 June, as reductions in cases began to be reported, centres were first asked if they were in a region still affected by rising cases, or if they had passed the peak of the first wave. These centres were asked additional questions about adaptations made to their standard pathways to permit elective surgery to resume.ResultsThe impact of the pandemic continued to be felt well after countries' first peak was thought to have passed in 2020. Aneurysm screening had not returned to normal in 21.7% of centres. Carotid surgery was still offered on a case by case basis in 33.8% of centres, and only 52.9% of centres had returned to their normal aneurysm threshold for surgery. Half of centres (49.4%) believed their management of lower limb ischaemia continued to be negatively affected by the pandemic. Reduced operating theatre capacity continued in 45.5% of centres. Twenty per cent of responding centres documented a backlog of at least 20 aortic repairs. At least one negative swab and 14 days of isolation were the most common strategies used for permitting safe elective surgery to recommence.ConclusionCentres reported a broad return of services approaching pre-pandemic "normal" by July 2020. Many introduced protocols to manage peri-operative COVID-19 risk. Backlogs in cases were reported for all major vascular surgeries.

Published
2022

5. Which inflammatory marker, between systemic immune-inflammation index and neutrophil to eosinophil ratio, is associated with Peyronie’s disease and are there any implications for a better understanding of its mechanisms?

Author

Crocetto, Felice, Imbimbo, Ciro, Barone, Biagio, Turchino, Davide, Bracale, Umberto Marcello, Peluso, Antonio, Panagrosso, Marco, Falcone, Alfonso, Mirto, Benito Fabio, De Luca, Luigi, Sicignano, Enrico, Del Giudice, Francesco, Busetto, Gian Maria, Lucarelli, Giuseppe, Giampaglia, Gaetano, Manfredi, Celeste, Ferro, Matteo, and Tarantino, Giovanni

Published
2023
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11. Socio-Cultural Aspects of Diabetic Foot: An Ethnographic Study and an Integrated Model Proposal.

Author

Costa, Davide, Gallelli, Giuseppe, Scalise, Enrica, Ielapi, Nicola, Bracale, Umberto Marcello, and Serra, Raffaele

Subjects
DIABETIC foot, PEOPLE with diabetes, TRADITIONAL medicine, DIABETES, ECOLOGICAL houses, ETHNOLOGY
Abstract

Background: Diabetes mellitus (DM) is an ongoing and growing health problem worldwide, with a series of important complications such as diabetic foot that can significatively reduce the quality of life of affected patients. This study aims to explore the socio-cultural aspects of patients with diabetic foot, analyzing the following research question: "What are the socio-cultural aspects experienced by patients with diabetic foot?" Methods: A qualitative design using an ethnographic approach was applied to study the social and cultural aspects of Italian diabetic foot patients. Results: We included 20 key informants: 13 men and 7 women. Ages ranged from 54 to 71, with an average age of 61.2. The data analysis revealed five main themes: perceptions of diabetic foot, living with diabetic foot, impacts of culture and economic performance, barriers to health and diabetic foot, and home remedies and alternative medicine. Conclusions: This study provides a new perspective on the influence of cultural factors on the health of diabetic foot patients, showing various factors related to a lack of knowledge and training, fear, and acceptance of diabetic foot. This study also presents a new integrated model which will allow patients and practitioners to act on the various critical issues that emerged from our research. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Documenting the Recovery of Vascular Services in European Centres Following the Initial COVID-19 Pandemic Peak: Results from a Multicentre Collaborative Study

Author

Ruffino, Maria Antonella, Chan, Sharon, Coughlin, Patrick, Awopetu, Ayoola, Stather, Philip, Lane, Tristan, Theodosiou, Dimitrios, Ahmed, Mohamed Abozeid, Vasudevan, Thodur, Ibrahim, Mohammed, Al Maadany, Faraj, Eljareh, Mohamed, Alkhafeefi, Fatimah Saad, Coscas, Raphael, Ünal, Ertekin Utku, Pulli, Raffaele, Zacà, Sergio, Angiletta, Domenico, Kotsis, Thomas, Moawad, Magdy, Tozzi, Matteo, Patelis, Nikolaos, Lazaris, Andreas M., Chuen, Jason, Croo, Alexander, Tsolaki, Elpiniki, Zenunaj, Gladiol, Kamal, Dhafer, Tolba, Mahmoud MH., Maresch, Martin, Khetarpaul, Vipul, Mills, Joseph, Gangwani, Gaurav, Elahwal, Mohamed, Khalil, Rana, Azab, Mohammed A., Mahomed, Anver, Whiston, Richard, Contractor, Ummul, Esposito, Davide, Pratesi, Carlo, Giacomelli, Elena, Troncoso, Martín Veras, Elkouri, Stephane, Johansson, Flavia Gentile, Dodos, Ilias, Benezit, Marie, Vidoedo, José, Rocha-Neves, João, Pereira-Neves, António Henrique, Dias-Neto, Marina Felicidade, Campos Jácome, Ana Filipa, Loureiro, Luis, Silva, Ivone, Garza-Herrera, Rodrigo, Canata, Victor, Bezard, Charlotte, Bowser, Kathryn, Tobar, Jorge Felipe, Vera, Carlos Gomez, Parra, Carolina Salinas, Lopez, Eugenia, Serra, Yvis Gadelha, Varela, Juan, Rubio, Vanessa, Victoria, Gerardo, Johnson, Adam, O’Banion, Leigh Ann, Makar, Ragai, Tantawy, Tamer Ghatwary, Storck, Martin, Jongkind, Vincent, falah, Orwa, McBride, Olivia, Isik, Arda, Papaioannou, Athanasios, Ocke Reis, Paulo Eduardo, Bracale, Umberto Marcello, Atkins, Ellie, Tinelli, Giovanni, Scott, Emma, Wales, Lucy, Sivaharan, Ashwin, Priona, Georgia, Nesbitt, Craig, Grainger, Tabitha, Shelmerdine, Lauren, Chong, Patrick, Bajwa, Adnan, Arwynck, Luke, Hadjievangelou, Nancy, Elbasty, Ahmed, Rubio, Oscar, Ricardo, Michael, Ulloa, Jorge H., Tarazona, Marcos, Pabon, Manuel, Pitoulias, Georgios, Corless, Kevin, Ioannidis, Orestis, Friedrich, Oliver, Van Herzeele, Isabelle, Vijaynagar, Badri, Cohnert, Tina, Bell, Rachel, Moore, Hayley, Saha, Prakash, Gifford, Edward, Laine, Matti, Barkat, Adel, Karkos, Christos, Binti Safri, Lenny Suryani, Buitron, Gabriel, Del Castillo, Javier, Carrera, Paul, Salinas, Nilson, Biagioni, Rodrigo Bruno, Benites, Sergio, Mafla, César Andrés, Pian, Putera Mas, Albino, Pereira, Serrano, Ernesto, Marin, Andres, González, Marco, Foreroga, Marsha, Russo, Alejandro, Reyes, Andrés, Guglielmone, Daniel, Grillo, Lorena, Flumignan, Ronald, Palones, Francisco Gomez, Silveira, Pierre Galvagni, Ramely, Rosnelifaizur Bin, Edeiken, Sara, Chetter, Ian, Green, Lucy, Sudarsanam, Abhilash, Lyons, Oliver, Lemmon, Gary, Neville, Richard, Castelli, Mariano, Hinojosa, Carlos A., Carvajal, Rubén Rodríguez, Rivera, Aksim, Wong, Peng, Drudi, Laura, Perkins, Jeremy, Sieunarine, Kishore, Attia, Doaa, Atef, Mahmoud, Eftychios, Lostoridis, Weaver, Fred, Ren, Leong Chuo, Alomari, Mohannad, Jamjoom, Reda, Aljarrah, Qusai, Abbas, Ayman, Alomran, Faris, Kumar, Ambrish, Altoijri, Abdulmajeed, ElSanhoury, Kareem T., Alhumaid, Ahmed, Fekry, Tamer, Sekhar, Raghuram, Theodoridis, Panagiotis, Panagiotis, Theodoridis, Roditis, Konstantinos, Tsiantoula, Paraskevi, Antoniou, Afroditi, Soler, Raphael, Hasemaki, Natasha, Baili, Efstratia, Mpaili, Eustratia, Huasen, Bella, Wallace, Tom, Duncan, Andrew, Metcalfe, Matthew, Mannoia, Kristyn, Bechara, Carlos F., Tsilimparis, Nikolaos, Aranson, Nathan, Riding, David, Palena, Mariano, McDonnell, Ciarán, Mouawad, Nicolas J., Banegas, Shonda, Rossi, Peter, Oshodi, Taohid, Diaz, Rodney, Afifi, Rana, Dindyal, Shiva, Thapar, Ankur, Kordzadeh, Ali, Pullas, Gonzalo, Lin, Stephanie, Davies, Chris, Darvall, Katy, Kodama, Akio, Gooneratne, Thushan, Gunawansa, Nalaka, Munoz, Alberto, Jie, Ng Jun, Bradley, Nicholas, Al-Jundi, Wissam, Meyer, Felicity, Lee, Cheong, Malina, Martin, Renton, Sophie, Lui, Dennis, Batchelder, Andrew, Oszkinis, Grzegorz, Freyrie, Antonio, Giordano, Jacopo, Saratzis, Nikolaos, Tigkiropoulos, Konstantinos, Kyriakos, Stavridis, Popov, Guriy, Cheema, Muhammad Usman, Lapolla, Pierfrancesco, Ling Patricia, Yih Chun, Ennab, Raed, Ullery, Brant W., Pasenidou, Ketino, Tam, Jacky, Sidel, Gabriel, Jayaprakash, Vivek Vardhan, Bennett, Lisa, Hardy, Simon, Davies, Emma, Baker, Sara, Wijesinghe, Lasantha, Tam, Adam, McCune, Ken, Chana, Manik, Lowe, Chris, Goh, Aaron, Powezka, Katarzyna, Kyrou, Ioanna, Altaf, Nishath, Harkin, Denis, Travers, Hannah, Cragg, James, sharif, Atif, Akhtar, Tasleem, Chávez, José Antonio, Ordonez, Claudia, Mazzurco, Martin, Choke, Edward, Asghar, Imran, Summerour, Virginia, Dunlop, Paul, Morley, Rachel, Hardy, Thomas, Bevis, Paul, Cuff, Robert, Stavroulakis, Konstantinos, Beropoulis, Efthymios, Argyriou, Angeliki, Loftus, Ian, Azhar, Bilal, Sheth, Sharvil, Usai, Marco Virgilio, Choudhry, Asad, Nicole, Kira, Boyle, Emily, Joyce, Doireann, Abdelaty Hassan, Mohammed Hassan, Saltiel, Alberto, Frahm-Jensen, Gert, Antoniou, George, Elhadi, Muhammed, Kimyaghalam, Ali, Malgor, Rafael, O'Banion, Leigh Ann, Telve, Diego, Isaak, Andrej, Schmidli, Jürg, McKevitt, Kevin, Siddiqui, Tam, Asciutto, Giuseppe, Floros, Nikolaos, Papadopoulos, George, Kafetzakis, Alexandros, Koutsias, Stylianos G., Nana, Petroula, Giannoukas, Athanasios, Kakkos, Stavros, Moulakakis, Konstantinos G., Shafique, Natasha, Jawien, Arkadiusz, Popplewell, Matthew, Imray, Chris, Abayasekara, Kumar, Rowlands, Timothy, Kuhan, Ganesh, Rajagopalan, Sriram, Jaipersad, Anthony, Sadia, Uzma, Kobe, Isaac, Mittapalli, Devender, Enemosah, Ibrahim, Behrendt, Christian-Alexander, Beck, Adam, Almudhafer, Muayyad, Ancetti, Stefano, Jacobs, Donald, Jayakumar, Priya, Malekpour, Fatemeh, Shalhub, Sherene, Keldiyorov, Boboyor, Simon, Meryl, Khashram, Manar, Rich, Nicole, Shepherd, Amanda, Meecham, Lewis, Doherty, Daniel, and Benson, Ruth A.

Published
2022
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14. Clinical and Pathological Correlations in Chronic Venous Disease

Author

Serra, Raffaele, Bracale, Umberto Marcello, Chilà, Caterina, Renne, Maria, Mignogna, Chiara, Ielapi, Nicola, Ciranni, Salvatore, Torcia, Giuseppina, Bevacqua, Egidio, Di Taranto, Maria Donata, Mastroroberto, Pasquale, Serraino, Giuseppe Filiberto, Provenzano, Michele, and Andreucci, Michele

Published
2022
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18. The Shaggy Aorta Syndrome: An Updated Review

Author

Serra, Raffaele, Bracale, Umberto Marcello, Jiritano, Federica, Ielapi, Nicola, Licastro, Noemi, Provenzano, Michele, Andreucci, Michele, Pingitore, Armando, de Franciscis, Stefano, Mastroroberto, Pasquale, and Serraino, Giuseppe Filiberto

Published
2021
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19. Omics Science and Social Aspects in Detecting Biomarkers for Diagnosis, Risk Prediction, and Outcomes of Carotid Stenosis.

Author

Costa, Davide, Scalise, Enrica, Ielapi, Nicola, Bracale, Umberto Marcello, Faga, Teresa, Michael, Ashour, Andreucci, Michele, and Serra, Raffaele

Subjects
CAROTID artery stenosis, LIFE sciences, CAROTID artery, TRANSCRIPTOMES, ATHEROSCLEROTIC plaque, METABOLOMICS
Abstract

Carotid stenosis is characterized by the progressive narrowing of the carotid arteries due to the formation of atherosclerotic plaque, which can lead to stroke and death as major complications. Numerous biomarkers allow for its study and characterization, particularly those related to "omics" sciences. Through the most common research databases, we report representative studies about carotid stenosis biomarkers based on genomics, transcriptomics, proteomics, and metabolomics in a narrative review. To establish a priority among studies based on their internal validity, we used a quality assessment tool, the Scale for the Assessment of Narrative Review Articles (SANRA). Genes, transcriptomes, proteins, and metabolites can diagnose the disease, define plaque connotations, predict consequences after revascularization interventions, and associate carotid stenosis with other patient comorbidities. It also emerged that many aspects determining the patient's psychological and social sphere are implicated in carotid disease. In conclusion, when taking the multidisciplinary approach that combines human sciences with biological sciences, it is possible to comprehensively define a patient's health and thus improve their clinical management through precision medicine. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Managing Peripheral Artery Disease in Diabetic Patients: A Questionnaire Survey from Vascular Centers of the Mediterranean Federation for the Advancing of Vascular Surgery (MeFAVS)

Author

Giribono, Anna Maria, Ferrante, Liborio, de Donato, Gianmarco, Dinoto, Ettore, Bajardi, Guido, Illario, Maddalena, Bouayed, Mohamed N., Saleem, Ben R., Pulli, Raffaele, Gossetti, Bruno, Pane, Bianca, Castelli, Patrizio, Tozzi, Matteo, Sraieb, Tarek, Setacci, Francesco, Stella, Andrea, De Luca, Vincenzo, Bracale, Umberto Marcello, Ammollo, Raffaele Pio, Hussein, Emad A., Hoballah, Jamal J., Goeau-Brissonniere, Olivier, Taurino, Maurizio, Setacci, Carlo, Pecoraro, Felice, and Bracale, Giancarlo

Published
2020
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22. Endurant Stent Graft for Treatment of Abdominal Aortic Aneurysm Inside and Outside of the Instructions for Use for the Proximal Neck: A 14-Year, Single-Center Experience

Author

Accarino, Giulio, primary, De Vuono, Francesco, additional, Accarino, Giancarlo, additional, Fornino, Giovanni, additional, Puca, Aniello Enrico, additional, Fimiani, Rodolfo, additional, Parrella, Valentina, additional, Savarese, Giovanni, additional, Furgiuele, Sergio, additional, Vecchione, Carmine, additional, Galasso, Gennaro, additional, and Bracale, Umberto Marcello, additional

Published
2024
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26. Mid-Term Results of an Italian Multicentric Experience with the RoadsaverTM Dual-Layer Carotid Stent System

Author

Silvestri, Olga, primary, Accarino, Giulio, additional, Turchino, Davide, additional, Squizzato, Francesco, additional, Piazza, Michele, additional, Bastianon, Martina, additional, Di Gregorio, Sara, additional, Pratesi, Giovanni, additional, Antonello, Michele, additional, Costa, Davide, additional, Serra, Raffaele, additional, and Bracale, Umberto Marcello, additional

Published
2024
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27. Molecular Insight into Acute Limb Ischemia.

Author

Costa, Davide, Ielapi, Nicola, Perri, Paolo, Minici, Roberto, Faga, Teresa, Michael, Ashour, Bracale, Umberto Marcello, Andreucci, Michele, and Serra, Raffaele

Subjects
ATHEROSCLEROTIC plaque, EXTRACELLULAR matrix, MUSCLE cells, SMOOTH muscle, ISCHEMIA
Abstract

Acute limb ischemia (ALI) is defined as a sudden reduction in blood flow to a limb, resulting in cessation of blood flow and, therefore, cessation of the delivery of nutrients and oxygen to the tissues of the lower limb. Despite optimal treatment to restore blood flow to ischemic tissues, some patients may suffer from ischemia/reperfusion (I/R) syndrome, the most severe complication after a revascularization procedure used to restore blood flow. There are multiple molecular and cellular factors that are involved in each phase of ALI. This review focuses firstly on molecular and cellular factors of arterial thrombosis, highlighting the role of atherosclerotic plaques, smooth muscle cells (SMCs), and cytokine which may alter key components of the extracellular matrix (ECM). Then, molecular and cellular factors of arterial embolism will be discussed, highlighting the importance of thrombi composition. Molecular and cellular factors of ischemia/reperfusion syndrome are analyzed in depth, highlighting several important mechanisms related to tissue damage, such as inflammation, apoptosis, autophagy, necrosis, and necroptosis. Furthermore, local and general complications of ALI are discussed in the context of molecular alterations. Ultimately, the role of novel biomarkers and targeted therapies is discussed. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Risk of Bleeding in Elderly Patients Undergoing Transcatheter Aortic Valve Implantation or Surgical Aortic Valve Replacement.

Author

Jiritano, Federica, Serraino, Giuseppe Filiberto, Sorrentino, Sabato, Napolitano, Desirèe, Costa, Davide, Ielapi, Nicola, Bracale, Umberto Marcello, Mastroroberto, Pasquale, Andreucci, Michele, and Serra, Raffaele

Subjects
SURGICAL blood loss, CARDIOVASCULAR diseases risk factors, HYPERTENSION, HEART valve prosthesis implantation, SCIENTIFIC observation, HEMORRHAGIC stroke, MAJOR adverse cardiovascular events, AGE distribution, ISCHEMIC stroke, SURGICAL complications, SURGERY, PATIENTS, RETROSPECTIVE studies, MANN Whitney U Test, FISHER exact test, RISK assessment, TREATMENT effectiveness, HOSPITAL mortality, COMPARATIVE studies, T-test (Statistics), HYPERLIPIDEMIA, SEVERITY of illness index, REOPERATION, CHI-squared test, DESCRIPTIVE statistics, RED blood cell transfusion, LOGISTIC regression analysis, STATISTICAL models, DATA analysis software, AORTIC valve diseases, HEMORRHAGE, DISEASE risk factors, EVALUATION, OLD age
Abstract

Background: Bleeding complications are strong predictors of mortality and major morbidity in elderly patients undergoing surgical aortic valve replacement (SAVR) or transcatheter aortic valve implantation (TAVI). Despite the high prevalence of frailty in this population, little is known about its effects on bleeding risk. Methods: We conducted a retrospective observational study of 502 patients undergoing isolated SAVR or TAVI between January 2015 and February 2022. The occurrence of blood products transfusions and MACEs were the primary endpoints. In-hospital mortality was the secondary endpoint. Results: The Elderly group (age < 80 years old) included 475 subjects, whereas the Very Elderly group (age ≥ 80 years old) included 127 patients. The need for blood product transfusion was similar among the two groups, regardless of the type of procedure. MACEs occurred similarly between groups [SAVR: Elderly group: 7.9% vs. Very Elderly group: 8.6%, p = 0.864; TAVI: Elderly group: 5.5% vs. Very Elderly group: 8.7%, p = 0.378]. The was no difference in in-hospital mortality rate in patients submitted to TAVI, whereas very elderly patients had higher mortality rate compared to the elderly patients submitted to SAVR [SAVR: Elderly group: 0% vs. Very Elderly group: 2.8%, p = 0.024; TAVI: Elderly group: 4,8% vs. Very Elderly group: 8%, p = 0.389]. Conclusions: Age alone should not be considered as a predictive factor for post-operative adverse events or in-hospital mortality in elderly patients with severe symptomatic AS. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Hyperkalemia in CKD: an overview of available therapeutic strategies

Author

Costa, Davide, primary, Patella, Gemma, additional, Provenzano, Michele, additional, Ielapi, Nicola, additional, Faga, Teresa, additional, Zicarelli, Mariateresa, additional, Arturi, Franco, additional, Coppolino, Giuseppe, additional, Bolignano, Davide, additional, De Sarro, Giovambattista, additional, Bracale, Umberto Marcello, additional, De Nicola, Luca, additional, Chiodini, Paolo, additional, Serra, Raffaele, additional, and Andreucci, Michele, additional

Published
2023
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34. Metalloproteinases between History, Health, Disease, and the Complex Dimension of Social Determinants of Health

Author

Costa, Davide, primary, Ielapi, Nicola, additional, Minici, Roberto, additional, Bevacqua, Egidio, additional, Ciranni, Salvatore, additional, Cristodoro, Lucia, additional, Torcia, Giuseppina, additional, Di Taranto, Maria Donata, additional, Bracale, Umberto Marcello, additional, Andreucci, Michele, additional, and Serra, Raffaele, additional

Published
2023
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36. Sex Related Differences and Factors Associated With Peri-Procedural and One Year Mortality in Chronic Limb Threatening Ischaemia Patients

Author

Martelli, Eugenio, Zamboni, Matilde, Sotgiu, Giovanni, Saderi, Laura, Federici, Massimo, Sangiorgi, Giuseppe, Puci, Mariangela Valentina, Martelli, Allegra Rosa, Messina, Teresa, Frigatti, Paolo, Borrelli, Maria Pia, Ruotolo, Carlo, Ficarelli, Ilaria, Rubino, Paolo, Pezzo, Francesco, Carbonari, Luciano, Angelini, Andrea, Galeazzi, Edoardo, Calia di Pinto, Luca, Fiore, Franco Michelino, Palmieri, Armando, Ventoruzzo, Giorgio, Mazzitelli, Giulia, Ragni, Franco, Bozzani, Antonio, Forliti, Enzo, Castagno, Claudio, Volpe, Pietro, Massaro, Mafalda, Moniaci, Diego, Pagliasso, Elisa, Peretti, Tania, Ferrari, Mauro, Troisi, Nicola, Modugno, Piero, Maiorano, Maurizio, Bracale, Umberto Marcello, Panagrosso, Marco, Monaco, Mario, Giordano, Giovanni, Natalicchio, Giuseppe, Biello, Antonella, Celoria, Giovanni Maria, Amico, Alessio, Di Bartolo, Mauro, Martelli, Massimiliano, Munaò, Roberta, Razzano, Davide, Colacchio, Giovanni, Bussetti, Francesco, Lanza, Gaetano, Cardini, Antonio, Di Benedetto, Bartolomeo, De Laurentis, Mario, Taurino, Maurizio, Sirignano, Pasqualino, Cappiello, Pierluigi, Esposito, Andrea, Trimarchi, Santi, Romagnoli, Silvia, Padricelli, Andrea, Giudice, Giorgio, Crinisio, Adolfo, Di Nardo, Giovanni, Battaglia, Giuseppe, Tringale, Rosario, De Vivo, Salvatore, Compagna, Rita, Tolva, Valerio Stefano, D'Alessio, Ilenia, Curci, Ruggiero, Giovannetti, Simona, D'Arrigo, Giuseppe, Basile, Giusi, Frigerio, Dalmazio, Veraldi, Gianfranco, Mezzetto, Luca, Ippoliti, Arnaldo, Oddi, Fabio Massimo, and Settembrini, Alberto Maria

Published
2024
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37. Abdominal aortic aneurysm: natural history, pathophysiology and translational perspectives

Author

Accarino, Giulio, Giordano, Antonio Nicola, Falcone, Martina, Celano, Adriana, Vassallo, Maria Giovanna, Fornino, Giovanni, Bracale, Umberto Marcello, Vecchione, Carmine, Galasso, Gennaro, Accarino, Giulio, Giordano, Antonio Nicola, Falcone, Martina, Celano, Adriana, Vassallo, Maria Giovanna, Fornino, Giovanni, Bracale, Umberto Marcello, Vecchione, Carmine, and Galasso, Gennaro

Subjects
Abdominal aortic aneurysm, Primary prevention, Atherosclerosis, Smoking, Dyslipidemia, General Earth and Planetary Sciences, General Environmental Science
Abstract

An abdominal aortic aneurysm (AAA) is a degenerative pathology that affects the infrarenal segment of the aorta, leading to its progressive dilatation and eventually rupture. The infrarenal segment is involved in 80% of the aortic aneurisms, and represents alone 30% of all aneurysms. The natural history of the disease is characterized by the progressive increase of the aortic diameter associated with proportionally higher risk of rupture, particularly for cases with diameter greater than 5.5 cm. In case of rupture the mortality rate is very high, independently from the endovascular or surgical treatment. The most important risk factors are older age, smoking, hypertension, dyslipidemia, and family history of AAA. The most frequent form is “atherosclerotic”, but infectious, collagen disease-related, immune dysregulation-related, and post-traumatic AAA have also been described. Albeit multiple pathogenetic hypotheses have been proposed, the role of metallo-proteinases in the degeneration of the aortic wall seem to play a central role. Early detection of AAA is crucial for the identification and treatment before the onset of potentially life-threatening complications. Moreover, the individual risk stratification is fundamental for the clinical management and follow-up. The growing knowledge about the pathophysiology of AAA has the potential to lead to significant translational ad- vances. The challenge for the next years is to employ bioinformatic and genetic models, also based on artificial intel- ligence and machine learning approach, to develop novel screening methods and to stratify individuals at higher-risk or in the early stages of AAA.

Published
2023
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38. Metalloproteinases as Biomarkers and Sociomarkers in Human Health and Disease.

Author

Costa, Davide, Scalise, Enrica, Ielapi, Nicola, Bracale, Umberto Marcello, Andreucci, Michele, and Serra, Raffaele

Subjects
METALLOPROTEINASES, PROTEOLYTIC enzymes, BIOMARKERS, HEALTH literacy, PREDICTION models
Abstract

Metalloproteinases (MPs) are zinc-dependent enzymes with proteolytic activity and a variety of functions in the pathophysiology of human diseases. The main objectives of this review are to analyze a specific family of MPs, the matrix metalloproteinases (MMPs), in the most common chronic and complex diseases that affect patients' social lives and to better understand the nature of the associations between MMPs and the psychosocial environment. In accordance with the PRISMA extension for a scoping review, an examination was carried out. A collection of 24 studies was analyzed, focusing on the molecular mechanisms of MMP and their connection to the manifestation of social aspects in human disease. The complexity of the relationship between MMP and social problems is presented via an interdisciplinary approach based on complexity paradigm as a new approach for conceptualizing knowledge in health research. Finally, two implications emerge from the study: first, the psychosocial states of individuals have a profound impact on their overall health and disease conditions, which implies the importance of adopting a holistic perspective on human well-being, encompassing both physical and psychosocial aspects. Second, the use of MPs as biomarkers may provide physicians with valuable tools for a better understanding of disease when used in conjunction with "sociomarkers" to develop mathematical predictive models. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Mid-Term Results of an Italian Multicentric Experience with the Roadsaver TM Dual-Layer Carotid Stent System.

Author

Silvestri, Olga, Accarino, Giulio, Turchino, Davide, Squizzato, Francesco, Piazza, Michele, Bastianon, Martina, Di Gregorio, Sara, Pratesi, Giovanni, Antonello, Michele, Costa, Davide, Serra, Raffaele, and Bracale, Umberto Marcello

Subjects
MORTALITY risk factors, CAROTID artery surgery, PERIOPERATIVE care, RESEARCH, LENGTH of stay in hospitals, PATIENT aftercare, SCIENTIFIC observation, TRANSIENT ischemic attack, STROKE, CAROTID artery stenosis, SURGICAL stents, RETROSPECTIVE studies, SURGICAL complications, TREATMENT effectiveness, VASCULAR surgery, CORONARY restenosis, DESCRIPTIVE statistics, PROSTHETIC heart valves, KAPLAN-Meier estimator, EQUIPMENT & supplies, DISEASE risk factors, EVALUATION
Abstract

Background: Carotid artery stenting (CAS) using first-generation single-layer stents is widely accepted as a good alternative to standard carotid endarterectomy (CEA) but it is associated with worse outcomes in terms of both plaque prolapse and cerebral embolization. Aim: To evaluate the perioperative and midterm outcomes of CAS using the new-generation RoadsaverTM dual-layer micromesh-covered carotid stent. Methods: Herein, we present the results of an observational, retrospective, multicentric study on non-consecutive patients who underwent the CAS procedure between January 2017 and December 2022 at three Italian, high-volume vascular surgery centers. The inclusion criteria were the patients' eligibility for the CAS procedure in accordance with the current Italian guidelines, and the implantation of a Roadsaver stent. Both symptomatic and asymptomatic patients were included in the study. The patients requiring reintervention for carotid restenosis following CEA were also included. Perioperative data regarding procedural success was defined as the successful implantation of the device in the desired position, less than 30% residual stenosis, and the absence of intraoperative neurological complications. The primary outcome was any adverse cerebrovascular event such as stroke or transient ischemic attack (TIA) during the procedure and/or after discharge. The secondary outcomes were the need for further intervention, and all-cause death following procedure. Results: Three-hundred-fifty-three (353) patients were included in our study; the mean age was 74.3 years. A total of 5.9% of the patients were symptomatic on their operated side, while 7.3% had contralateral carotid occlusion. A cerebral embolic protection device (CPD) was employed in all patients. A total of 13.3% of the patients were operated on for restenosis after CEA Technical success was achieved in 96.9% of the cases with an intraoperative report of six TIAs (1.7%) and six ipsilateral strokes (1.7%). The mean hospital stay was 1.8 days. The thirty-day follow up showed one TIA and one more stroke. At the mean 35-month follow-up time, the primary outcome was present in six patients (1.7%), where four TIAs (1.1%) and two strokes (0.5%) were reported. Restenosis occurred in five patients (1.4%). Death for any cause was reported in 11 patients (3.1%). Conclusions: As most recent, high-quality studies show, the CAS procedure with second-generation devices such as the Roadsaver stent is safe and effective in preventing carotid-related cerebrovascular events in both symptomatic and asymptomatic patients. The intraoperative and postoperative cerebrovascular complication rate in high volume centers is very low, ensuring confidence in its employment for the CAS procedure along with a CPD as a valid alternative to CEA. [ABSTRACT FROM AUTHOR]

Published
2024
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44. Metalloproteinases in Cardiac Surgery: A Systematic Review

Author

Serraino, Giuseppe Filiberto, primary, Jiritano, Federica, additional, Costa, Davide, additional, Ielapi, Nicola, additional, Battaglia, Domenica, additional, Bracale, Umberto Marcello, additional, Mastroroberto, Pasquale, additional, Andreucci, Michele, additional, and Serra, Raffaele, additional

Published
2023
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46. Sex-Related Differences and Factors Associated with Peri-Procedural and 1-year Mortality in Chronic Limb-Threatening Ischemia Patients from the CLIMATE Italian Registry

Author

Martelli, Eugenio, primary, Zamboni, Matilde, additional, Sotgiu, Giovanni, additional, Saderi, Laura, additional, Federici, Massimo, additional, Sangiorgi, Giuseppe Massimo, additional, Puci, Mariangela Valentina, additional, Martelli, Allegra Rosa, additional, Messina, Teresa, additional, Frigatti, Paolo, additional, Borrelli, Maria Pia, additional, Ruotolo, Carlo, additional, Ficarelli, Ilaria, additional, Rubino, Paolo, additional, Pezzo, Francesco, additional, Carbonari, Luciano, additional, Angelini, Andrea, additional, Galeazzi, Edoardo, additional, Di Pinto, Luca Calia, additional, Fiore, Franco Michelino, additional, Palmieri, Armado, additional, Ventoruzzo, Giorgio, additional, Mazzitelli, Giulia, additional, Ragni, Franco, additional, Bozzani, Antonio, additional, Forliti, Enzo, additional, Castagno, Claudio, additional, Volpe, Pietro, additional, Massara, Mafalda, additional, Moniaci, Diego, additional, Pagliasso, Elisa, additional, Peretti, Tania, additional, Ferrari, Mauro, additional, Troisi, Nicola, additional, Modugno, Pietro, additional, Maiorano, Maurizio, additional, Bracale, Umberto Marcello, additional, Panagrosso, Marco, additional, Monaco, Mario, additional, Giordano, Giovanni, additional, Natalicchio, Giuseppe, additional, Biello, Antonella, additional, Celoria, Giovanni Maria, additional, Amico, Alessio, additional, Di Bartolo, Mauro, additional, Martelli, Massimiliano, additional, Munaó, Roberta, additional, Razzano, Davide, additional, Colacchio, Giovanni, additional, Bussetti, Francesco, additional, Lanza, Gaetano, additional, Cardini, Antonio, additional, Di Benedetto, Bartolomeo, additional, De Laurentis, Mario, additional, Taurino, Maurizio, additional, Sirignano, Pasqualino, additional, Cappiello, Pierluigi, additional, Esposito, Andrea, additional, Trimarchi, Santi, additional, Romagnoli, Silvia, additional, Padricelli, Andrea, additional, Giudice, Giorgio, additional, Crinisio, Adolfo, additional, Di Nardo, Giovanni, additional, Battaglia, Giuseppe, additional, Tringale, Rosario, additional, De Vivo, Salvatore, additional, Compagna, Rita, additional, Tolva, Valerio Stefano, additional, D'Alessio, Ilenia, additional, Curci, Ruggiero, additional, Giovannetti, Simona, additional, D'Arrigo, Giuseppe, additional, Basile, Giusi, additional, Frigerio, Dalmazio, additional, Veraldi, Gian Franco, additional, Mezzetto, Luca, additional, Ippoliti, Arnaldo, additional, Oddi, Fabio Massimo, additional, and Settembrini, Alberto Maria, additional

Published
2022
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48. Contributors

Author

Abecassis, Isaac Josh, primary, Agarwal, Vijay, additional, Agarwalla, Pankaj K., additional, Ahuja, Christopher S., additional, Alalade, Andrew Folusho, additional, Alli, Saira, additional, Aquilina, Kristian, additional, Armonda, Rocco A., additional, Baird, Lissa, additional, Bales, James W., additional, Bambakidis, Nicholas C., additional, Barrow, Daniel L., additional, Bauer, David F., additional, Beecher, Jeffrey S., additional, Bell, Randy S, additional, Belli, Antonio, additional, Benzel, Edward C., additional, Bonow, Robert H., additional, Bracale, Umberto Marcello, additional, Browd, Samuel R., additional, Bulsara, Ketan, additional, Cadotte, David W., additional, Cappabianca, Paolo, additional, Cavallo, Luigi Maria, additional, Chan, Alvin Y., additional, Chen, Roc Peng, additional, Chiarelli, Peter A., additional, Choudhri, Omar, additional, Chowdhary, Michelle, additional, Chu, Jason, additional, Cirivello, Michael J., additional, de Araújo Coimbra, Pablo Picasso, additional, Collins, Kelly L., additional, Daartz, Juliane, additional, de Divitiis, Oreste, additional, Deinsberger, Wolfgang, additional, Dekker, Simone E., additional, Dewan, Michael C., additional, Di Maio, Salvatore, additional, Ding, Dale, additional, Ellenbogen, Richard G., additional, Ene, Chibawanye, additional, Fehlings, Michael, additional, de Carvalho, Flávio Leitão, additional, Fink, James R., additional, Fink, Kathleen R. Tozer, additional, Fridley, Jared, additional, Ghobrial, George M., additional, Gleeson, Michael, additional, Goel, Atul, additional, Gokaslan, Ziya L., additional, Goodrich, James Tait, additional, Grant, Gerald A., additional, Gross, Bradley A., additional, Gruss, Joseph, additional, Halasz, Lia, additional, Hanak, Brian W., additional, Hankinson, Todd C., additional, Harrop, James S., additional, Heilman, Carl B., additional, Heller, Robert S., additional, Hoffer, S. Alan, additional, Hofstetter, Christoph P., additional, Hyam, Jonathan A., additional, Impastato, Kate, additional, Isik, Semra, additional, James, Greg, additional, Jha, R. Tushar, additional, Jones, Kristen E., additional, Jowdy, Patrick K., additional, Kalb, Samuel, additional, Keating, Robert F., additional, Kelly, Cory M., additional, Kitchen, Neil D., additional, Ko, Andrew L., additional, Koch, Matthew J., additional, Kondziolka, Douglas, additional, Kuo, Chao-Hung, additional, Larson, A. Noelle, additional, Lawton, Michael T., additional, Lee, Amy, additional, Levitt, Michael R., additional, Levy, Elad I., additional, Loeffler, Jay S., additional, Lucas, Timothy H, additional, Magge, Suresh N., additional, Marchan, Edward M., additional, Marsh, Henry, additional, Mason, Alexander M., additional, Mastorakos, Panagiotis, additional, McCracken, D. Jay, additional, Midha, Rajiv, additional, Morton, Ryan P., additional, Mueller, Kyle, additional, Mullin, Jeffrey P., additional, Nadi, Mustafa, additional, Nakaji, Peter, additional, Nerva, John D., additional, Niazi, Toba N., additional, Ojemann, Jeffrey G., additional, Oyelese, Adetokunbo, additional, Oyesiku, Nelson M., additional, Patel, Anoop P., additional, Peterson, Eric C., additional, Polly, David W., additional, Quach, Helen, additional, Rajan, Shobana, additional, Ravanpay, Ali, additional, Robinson, Leslie C., additional, Rocha, Ricardo, additional, Royce, Trevor J., additional, Rutka, James T., additional, Sekhar, Laligam N., additional, Selman, Warren, additional, Shah, Ashish H., additional, Shallwani, Hussain, additional, Sharma, Deepak, additional, Sharma, Mohan Raj, additional, Silbergeld, Daniel L., additional, Silva, Dulanka, additional, da Silva, Harley Brito, additional, Silveira, Luke, additional, Smith, Edward, additional, Solari, Domenico, additional, Soliman, Hesham, additional, Somma, Teresa, additional, Starke, Robert M., additional, Straus, David C., additional, Teo, Charles, additional, Toma, Ahmed, additional, Tseng, Yolanda D., additional, Tubbs, R. Shane, additional, Vakharia, Kunal, additional, Villa, Alessandro, additional, Wait, Scott D., additional, Walcott, Brian P., additional, Wathen, Connor, additional, Wellons, John C., additional, Wilson, Mark, additional, Wolf, Amparo, additional, Xu, Linda, additional, Yang, Tong, additional, Young, Christopher C., additional, and Zrinzo, Ludvic, additional

Published
2018
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49. Endoscopic Approaches to Skull Base Lesions

Author

Cappabianca, Paolo, primary, Villa, Alessandro, additional, Cavallo, Luigi Maria, additional, Somma, Teresa, additional, Bracale, Umberto Marcello, additional, de Divitiis, Oreste, additional, and Solari, Domenico, additional

Published
2018
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