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1. The neurophysiological brain-fingerprint of Parkinson’s disease

Author

Breitner, John, Poirier, Judes, Baillet, Sylvain, Bellec, Pierre, Bohbot, Véronique, Chakravarty, Mallar, Collins, Louis, Etienne, Pierre, Evans, Alan, Gauthier, Serge, Hoge, Rick, Ituria-Medina, Yasser, Multhaup, Gerhard, Münter, Lisa-Marie, Rajah, Natasha, Rosa-Neto, Pedro, Soucy, Jean-Paul, Vachon-Presseau, Etienne, Villeneuve, Sylvia, Amouyel, Philippe, Appleby, Melissa, Ashton, Nicholas, Auld, Daniel, Ayranci, Gülebru, Bedetti, Christophe, Beland, Marie-Lise, Blennow, Kaj, Westman, Ann Brinkmalm, Cuello, Claudio, Dadar, Mahsa, Daoust, Leslie-Ann, Das, Samir, Dauar-Tedeschi, Marina, De Beaumont, Louis, Dea, Doris, Descoteaux, Maxime, Dufour, Marianne, Farzin, Sarah, Ferdinand, Fabiola, Fonov, Vladimir, Gonneaud, Julie, Kat, Justin, Kazazian, Christina, Labonté, Anne, Lafaille-Magnan, Marie-Elyse, Lalancette, Marc, Lambert, Jean-Charles, Leoutsakos, Jeannie-Marie, Mahar, Laura, Mathieu, Axel, McSweeney, Melissa, Meyer, Pierre-François, Miron, Justin, Near, Jamie, NewboldFox, Holly, Nilsson, Nathalie, Orban, Pierre, Picard, Cynthia, Binette, Alexa Pichet, Poline, Jean-Baptiste, Rabipour, Sheida, Salaciak, Alyssa, Settimi, Matthew, Subramaniapillai, Sivaniya, Tam, Angela, Tardif, Christine, Théroux, Louise, Tremblay-Mercier, Jennifer, Tullo, Stephanie, Ulku, Irem, Vallée, Isabelle, Zetterberg, Henrik, Nair, Vasavan, Pruessner, Jens, Aisen, Paul, Anthal, Elena, Barkun, Alan, Beaudry, Thomas, Benbouhoud, Fatiha, Brandt, Jason, Carmo, Leopoldina, Carrier, Charles Edouard, Cheewakriengkrai, Laksanun, Courcot, Blandine, Couture, Doris, Craft, Suzanne, Dansereau, Christian, Debacker, Clément, Desautels, René, Dubuc, Sylvie, Duclair, Guerda, Eisenberg, Mark, El-Khoury, Rana, Faubert, Anne-Marie, Fontaine, David, Frappier, Josée, Frenette, Joanne, Gagné, Guylaine, Gervais, Valérie, Giles, Renuka, Gordon, Renee, Jack, Clifford, Jutras, Benoit, Khachaturian, Zaven, Knopman, David, Kostopoulos, Penelope, Lapalme, Félix, Lee, Tanya, Lepage, Claude, Leppert, Illana, Madjar, Cécile, Maillet, David, Maltais, Jean-Robert, Mathotaarachchi, Sulantha, Mayrand, Ginette, Michaud, Diane, Montine, Thomas, Morris, John, Pagé, Véronique, Pascoal, Tharick, Peillieux, Sandra, Petkova, Mirela, Pogossova, Galina, Rioux, Pierre, Sager, Mark, Saint-Fort, Eunice Farah, Savard, Mélissa, Sperling, Reisa, Tabrizi, Shirin, Tariot, Pierre, Teigner, Eduard, Thomas, Ronald, Toussaint, Paule-Joanne, Tuwaig, Miranda, Venugopalan, Vinod, Verfaillie, Sander, Vogel, Jacob, Wan, Karen, Wang, Seqian, Yu, Elsa, Beaulieu-Boire, Isabelle, Blanchet, Pierre, Bogard, Sarah, Bouchard, Manon, Chouinard, Sylvain, Cicchetti, Francesca, Cloutier, Martin, Dagher, Alain, Degroot, Clotilde, Desautels, Alex, Dion, Marie Hélène, Drouin-Ouellet, Janelle, Dufresne, Anne-Marie, Dupré, Nicolas, Duquette, Antoine, Durcan, Thomas, Fellows, Lesley K., Fon, Edward, Gagnon, Jean-François, Gan-Or, Ziv, Genge, Angela, Jodoin, Nicolas, Karamchandani, Jason, Lafontaine, Anne-Louise, Langlois, Mélanie, Leveille, Etienne, Lévesque, Martin, Melmed, Calvin, Monchi, Oury, Montplaisir, Jacques, Panisset, Michel, Parent, Martin, Pham-An, Minh-Thy, Postuma, Ronald, Pourcher, Emmanuelle, Rao, Trisha, Rivest, Jean, Rouleau, Guy, Sharp, Madeleine, Soland, Valérie, Sidel, Michael, Wing Sun, Sonia Lai, Thiel, Alexander, Vitali, Paolo, da Silva Castanheira, Jason, Wiesman, Alex I., Hansen, Justine Y., and Misic, Bratislav

Published
2024
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5. Thin‐Film Organic Heteroepitaxy

Author

Dull, Jordan T., primary, He, Xu, additional, Viereck, Jonathan, additional, Ai, Qianxiang, additional, Ramprasad, Ritika, additional, Otani, Maria Clara, additional, Sorli, Jeni, additional, Brandt, Jason W., additional, Carrow, Brad P., additional, Tinoco, Arthur D., additional, Loo, Yueh‐Lin, additional, Risko, Chad, additional, Rangan, Sylvie, additional, Kahn, Antoine, additional, and Rand, Barry P., additional

Published
2023
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6. Subjective Cognitive Decline Is Associated With Altered Default Mode Network Connectivity in Individuals With a Family History of Alzheimer’s Disease

Author

Aisen, Paul, Anthal, Elena, Appleby, Melissa, Ayranci, Gülebru, Barkun, Alan, Beaudry, Thomas, Bellec, Pierre, Benbouhoud, Fatiha, Bohbot, Veronique, Brandt, Jason, Breitner, John, Carmo, Leopoldina, Carrier Charles, Edouard, Chakravarty, Mallar, Cheewakriengkrai, Laksanun, Collins, Louis, Courcot, Blandine, Couture, Doris, Craft, Suzanne, Cuello, Claudio, Dadar, Mahsa, Dansereau, Christian, DasSamir, Marina, Dauar-Tedeschi, Dea, Doris, Debacker, Clement, Desautels, Rene, Dubuc, Sylvie, Duclair, Guerda, Dufour, Marianne, Eisenberg, Mark, El-Khoury, Rana, Etienne, Pierre, Evans, Alan, Faubert, Anne-Marie, Ferdinand, Fabiola, Fonov, Vladimir, Fontaine, David, Frappier, Josée, Joanne, Frenette, Gagne, Guylaine, Gauthier, Serge, Gervais, Valérie, Giles, Renuka, Gonneaud, Julie, Gordon, Renee, Hoge, Rick, Hyman, Bradley, Ituria-Medina, Yasser, Jack, Clifford, Kat, Justin, Kazazian, Christina, Khachaturian, Zaven, Knopman, David, Kostopoulos, Penelope, Labonte, Anne, Lafaille-Magnan, Marie-Elyse, Lee, Tanya, Leoutsakos, Jeannie-Marie, Lepage, Claude, Leppert, Illana, Madjar, Cécile, Mahar, Laura, Maillet, David, Maltais, Jean-Robert, Mathieu, Axel, Mathotaarachchi, Sulantha, Maultaup, Gerhard, Mayrand, Ginette, Meyer, Pierre-François, Michaud, Diane, Miron, Justin, Montine, Thomas, Morris, John, Münter, Lisa-Marie, Nair, Vasavan, Near, Jamie, Newbold-Fox, Holly, Orban, Pierre, Page, Véronique, Pascoal, Tharick, Petkova, Mirela, Picard, Cynthia, Pichet Binette, Alexa, Pogossova, Galina, Poirier, Judes, Pruessner, Jens, Rajah, Natasha, Rioux, Pierre, Rosa-Neto, Pedro, Sager, Mark, Saint-Fort, Eunice Farah, Savard, Mélissa, Sperling, Reisa, Tabrizi, Shirin, Tam, Angela, Tardif, Christine, Tariot, Pierre, Teigner, Eduard, Theroux, Louise, Thomas, Ronald, Toussaint, Paule-Joanne, Tremblay-Mercier, Jennifer, Tuwaig, Miranda, Vallee, Isabelle, Venugopalan, Vinod, Verfaillie, Sander, Villeneuve, Sylvia, Vogel, Jacob, Wan, Karen, Wang, Seqian, Yu, Elsa, Verfaillie, Sander C.J., Vachon-Presseau, Etienne, Ossenkoppele, Rik, Scheltens, Philip, van der Flier, Wiesje M., and Breitner, John C.S.

Published
2018
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7. Diet in Brain Health and Neurological Disorders : Risk Factors and Treatments

Author

Brandt, Jason

Abstract

The role of nutrition in health and disease has been appreciated from time immemorial. Around 400 B.C., Hippocrates wrote “Let food by thy medicine and medicine be thy food.” In the 12th century, the great philosopher and physician Moses Maimonides wrote “any disease that can be treated by diet should be treated by no other means.” Now, in the 21st century, we are bombarded by claims in the media of “superfoods,” wondrous nutritional supplements, and special diets that promise to cure or prevent disease, improve health and restore functioning. Much of the focus has been on neurological disease, brain health and psychological functioning (behavior, cognition, and emotion). The hyperbole aside, there has been considerable progress in the past decade in our understanding of the contribution of specific nutrients and dietary patterns to brain development, physiology, and functioning. This Special Issue of Brain Sciences is devoted to the latest research on the role of nutritional deficiencies and excesses in the genesis of brain dysfunction, and use of diet for the prevention and treatment of brain and mental disorders. Basic laboratory and clinical research studies of the immature, adult, and aged nervous system are all welcome.

Published
2019

14. Resting-state MRI functional connectivity as a neural correlate of multidomain lifestyle adherence in older adults at risk for Alzheimer's disease.

Author

Ai, Meishan, Morris, Timothy P., Zhang, Jiahe, de la Colina, Adrián Noriega, Tremblay-Mercier, Jennifer, Villeneuve, Sylvia, Whitfield-Gabrieli, Susan, Kramer, Arthur F., Geddes, Maiya R., Aisen, Paul, Anthal, Elena, Appleby, Melissa, Bellec, Pierre, Benbouhoud, Fatiha, Bohbot, Véronique, Brandt, Jason, Breitner, John C. S., Brunelle, Céline, Chakravarty, Mallar, and Cheewakriengkrai, Laksanun

Subjects
DISEASE risk factors, FUNCTIONAL magnetic resonance imaging, OLDER people, FUNCTIONAL connectivity, LARGE-scale brain networks
Abstract

Prior research has demonstrated the importance of a healthy lifestyle to protect brain health and diminish dementia risk in later life. While a multidomain lifestyle provides an ecological perspective to voluntary engagement, its association with brain health is still under-investigated. Therefore, understanding the neural mechanisms underlying multidomain lifestyle engagement, particularly in older adults at risk for Alzheimer's disease (AD), gives valuable insights into providing lifestyle advice and intervention for those in need. The current study included 139 healthy older adults with familial risk for AD from the Prevent-AD longitudinal aging cohort. Self-reported exercise engagement, cognitive activity engagement, healthy diet adherence, and social activity engagement were included to examine potential phenotypes of an individual's lifestyle adherence. Two adherence profiles were discovered using data-driven clustering methodology [i.e., Adherence to healthy lifestyle (AL) group and Non-adherence to healthy lifestyle group]. Resting-state functional connectivity matrices and grey matter brain features obtained from magnetic resonance imaging were used to classify the two groups using a support vector machine (SVM). The SVM classifier was 75% accurate in separating groups. The features that show consistently high importance to the classification model were functional connectivity mainly between nodes located in different prior-defined functional networks. Most nodes were located in the default mode network, dorsal attention network, and visual network. Our results provide preliminary evidence of neurobiological characteristics underlying multidomain healthy lifestyle choices. [ABSTRACT FROM AUTHOR]

Published
2023
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17. Amyloid and Tau Pathology Associations With Personality Traits, Neuropsychiatric Symptoms, and Cognitive Lifestyle in the Preclinical Phases of Sporadic and Autosomal Dominant Alzheimer’s Disease

Author

Pichet Binette, Alexa, primary, Vachon-Presseau, Étienne, additional, Morris, John, additional, Bateman, Randall, additional, Benzinger, Tammie, additional, Collins, D. Louis, additional, Poirier, Judes, additional, Breitner, John C.S., additional, Villeneuve, Sylvia, additional, Allegri, Ricardo, additional, Amtashar, Fatima, additional, Bateman, Randy, additional, Berman, Sarah, additional, Bodge, Courtney, additional, Brandon, Susan, additional, Brooks, William (Bill), additional, Buck, Jill, additional, Buckles, Virginia, additional, Chea, Sochenda, additional, Chhatwal, Jasmeer, additional, Chrem, Patricio, additional, Chui, Helena, additional, Cinco, Jake, additional, Clifford, Jack, additional, Cruchaga, Carlos, additional, D‘Mello, Mirelle, additional, Donahue, Tamara, additional, Douglas, Jane, additional, Edigo, Noelia, additional, Erekin-Taner, Nilufer, additional, Fagan, Anne, additional, Farlow, Marty, additional, Farrar, Angela, additional, Feldman, Howard, additional, Flynn, Gigi, additional, Fox, Nick, additional, Franklin, Erin, additional, Fujii, Hisako, additional, Gant, Cortaiga, additional, Gardener, Samantha, additional, Ghetti, Bernardino, additional, Goate, Alison, additional, Goldman, Jill, additional, Gordon, Brian, additional, Graff-Radford, Neill, additional, Gray, Julia, additional, Gurney, Jenny, additional, Hassenstab, Jason, additional, Hirohara, Mie, additional, Holtzman, David, additional, Hornbeck, Russ, additional, DiBari, Siri Houeland, additional, Ikeuchi, Takeshi, additional, Ikonomovic, Snezana, additional, Jerome, Gina, additional, Jucker, Mathias, additional, Karch, Celeste, additional, Kasuga, Kensaku, additional, Kawarabayashi, Takeshi, additional, Klunk, William (Bill), additional, Koeppe, Robert, additional, Kuder-Buletta, Elke, additional, Laske, Christoph, additional, Lee, Jae-Hong, additional, Levin, Johannes, additional, Marcus, Daniel, additional, Martins, Ralph, additional, Mason, Neal Scott, additional, Masters, Colin, additional, Maue-Dreyfus, Denise, additional, McDade, Eric, additional, Montoya, Lucy, additional, Mori, Hiroshi, additional, Nagamatsu, Akem, additional, Neimeyer, Katie, additional, Noble, James, additional, Norton, Joanne, additional, Perrin, Richard, additional, Raichle, Marc, additional, Ringman, John, additional, Roh, Jee Hoon, additional, Salloway, Stephen, additional, Schofield, Peter, additional, Shimada, Hiroyuki, additional, Shiroto, Tomoyo, additional, Shoji, Mikio, additional, Sigurdson, Wendy, additional, Sohrabi, Hamid, additional, Sparks, Paige, additional, Suzuki, Kazushi, additional, Swisher, Laura, additional, Taddei, Kevin, additional, Wang, Jen, additional, Wang, Peter, additional, Weiner, Mike, additional, Wolfsberger, Mary, additional, Xiong, Chengjie, additional, Xu, Xiong, additional, Tam, Angela, additional, Labonté, Anne, additional, Pichet Binette, Alexa, additional, Faubert, Anne-Marie, additional, Mathieu, Axel, additional, Madjar, Cécile, additional, Carrier, Charles Edouard, additional, Dansereau, Christian, additional, Kazazian, Christina, additional, Lepage, Claude, additional, Picard, Cynthia, additional, Maillet, David, additional, Michaud, Diane, additional, Couture, Doris, additional, Dea, Doris, additional, Cuello, Claudio, additional, Barkun, Alan, additional, Evans, Alan, additional, Courcot, Blandine, additional, Tardif, Christine, additional, Debacker, Clément, additional, Jack, Clifford R., additional, Fontaine, David, additional, Knopman, David S., additional, Maultaup, Gerhard, additional, Near, Jamie, additional, Leoutsakos, Jeannie-Marie, additional, Maltais, Jean-Robert, additional, Brandt, Jason, additional, Pruessner, Jens, additional, Morris, John C., additional, Cheewakriengkrai, Laksanun, additional, Münter, Lisa-Marie, additional, Collins, Louis, additional, Chakravarty, Mallar, additional, Sager, Mark A., additional, Dauar-Tedeschi, Marina, additional, Eisenberg, Mark, additional, Rajah, Natasha, additional, Aisen, Paul, additional, Toussaint, Joanne, additional, Rosa-Neto, Pedro, additional, Bellec, Pierre, additional, Kostopoulos, Penelope, additional, Etienne, Pierre, additional, Tariot, Pierre N., additional, Orban, Pierre, additional, Sperling, Reisa A., additional, Hoge, Rick, additional, Thomas, Ronald G., additional, Gauthier, Serge, additional, Craft, Suzanne, additional, Montine, Thomas J., additional, Nair, Vasavan, additional, Bohbot, Véronique, additional, Venugopalan, Vinod, additional, Fonov, Vladimir, additional, Ituria-Medina, Yasser, additional, Khachaturian, Zaven S., additional, Teigner, Eduard, additional, Anthal, Elena, additional, Yu, Elsa, additional, Ferdinand, Fabiola, additional, Pogossova, Galina, additional, Mayrand, Ginette, additional, Duclair, Guerda, additional, Gagné, Guylaine, additional, Newbold-Fox, Holly, additional, Leppert, Illana, additional, Vallée, Isabelle, additional, Vogel, Jacob W., additional, Tremblay-Mercier, Jennifer, additional, Frenette, Joanne, additional, Frappier, Josée, additional, Kat, Justin, additional, Miron, Justin, additional, Wan, Karen, additional, Mahar, Laura, additional, Carmo, Leopoldina, additional, Théroux, Louise, additional, Dadar, Mahsa, additional, Dufour, Marianne, additional, Lafaille-Magnan, Marie-Elyse, additional, Appleby, Melissa, additional, Savard, Mélissa, additional, Tuwaig, Miranda, additional, Petkova, Mirela, additional, Rioux, Pierre, additional, Meyer, Pierre-François, additional, El-Khoury, Rana, additional, Gordon, Renee, additional, Giles, Renuka, additional, Das, Samir, additional, Wang, Seqian, additional, Tabrizi, Shirin, additional, Mathotaarachchi, Sulantha, additional, Dubuc, Sylvie, additional, Lee, Tanya, additional, Beaudry, Thomas, additional, Gervais, Valérie, additional, Pagé, Véronique, additional, Gonneaud, Julie, additional, Ayranci, Gülebru, additional, Pascoal, Tharick A., additional, Desautels, René, additional, Benbouhoud, Fatiha, additional, Saint-Fort, Eunice Farah, additional, Verfaillie, Sander C.J., additional, Farzin, Sarah, additional, Salaciak, Alyssa, additional, Tullo, Stephanie, additional, Vachon-Presseau, Etienne, additional, Daoust, Leslie-Ann, additional, Köbe, Theresa, additional, Spreng, Nathan, additional, McSweeney, Melissa, additional, Nilsson, Nathalie, additional, Pishnamazi, Morteza, additional, and Bedetti, Christophe, additional

Published
2021
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22. Update on psychogenic nonepileptic seizures

Author

Brandt, Jason and Puente, Antonio N.

Subjects
Somatoform disorders -- Diagnosis -- Risk factors -- Care and treatment, Seizures (Medicine) -- Diagnosis -- Risk factors -- Care and treatment, Health, Psychology and mental health
Abstract

Psychogenic nonepileptic seizures (PNES) are episodes of altered movement, sensation, or reported experience that mimic epileptic seizures (ES) but are not the result of abnormal electrical discharges from the brain. [...]

Published
2015

28. Regional Hypoperfusion Predicts Decline in Everyday Functioning at Three-Year Follow-Up in Older Adults without Dementia.

Author

Sanchez, Danielle L., Thomas, Kelsey R., Edmonds, Emily C., Bondi, Mark W., Bangen, Katherine J., Brandt, Jason, and Alzheimer’s Disease Neuroimaging Initiative

Subjects
OLDER people, ALZHEIMER'S disease, COGNITION disorders, DEMENTIA, CEREBRAL circulation, MILD cognitive impairment, RESEARCH, PREDICTIVE tests, TIME, RESEARCH methodology, ACTIVITIES of daily living, MAGNETIC resonance imaging, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies, RESEARCH funding, QUESTIONNAIRES, LONGITUDINAL method
Abstract

Background: Increasing evidence indicates that cerebrovascular dysfunction may precede cognitive decline in aging and Alzheimer's disease (AD). Reduced cerebral blood flow (CBF) is associated with cognitive impairment in older adults. However, less is known regarding the association between CBF and functional decline, and whether CBF predicts functional decline beyond cerebrovascular and metabolic risk factors.Objective: To examine the association between regional CBF and functional decline in nondemented older adults.Method: One hundred sixty-six (N = 166) participants without dementia from the Alzheimer's Disease Neuroimaging Initiative underwent neuropsychological testing and neuroimaging. Pulsed arterial spin labeling magnetic resonance imaging was acquired to quantify resting CBF. Everyday functioning was measured using the Functional Assessment Questionnaire at baseline and annual follow-up visit across three years.Results: Adjusting for age, education, sex, cognitive status, depression, white matter hyperintensity volume, cerebral metabolism, and reference (precentral) CBF, linear mixed effects models showed that lower resting CBF at baseline in the medial temporal, inferior temporal, and inferior parietal lobe was significantly associated with accelerated decline in everyday functioning. Results were similar after adjusting for conventional AD biomarkers, including cerebrospinal fluid (CSF) amyloid-β (Aβ) and hyperphosphorylated tau (p-tau) and apolipoprotein E (APOE) ɛ4 positivity. Individuals who later converted to dementia had lower resting CBF in the inferior temporal and parietal regions compared to those who did not.Conclusion: Lower resting CBF in AD vulnerable regions including medial temporal, inferior temporal, and inferior parietal lobes predicted faster rates of decline in everyday functioning. CBF has utility as a biomarker in predicting functional declines in everyday life and conversion to dementia. [ABSTRACT FROM AUTHOR]

Published
2020
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29. Identifying neuropsychologically impaired physicians.

Author

Del Bene, Victor A. and Brandt, Jason

Subjects
*UROLOGISTS, *PHYSICIANS, *NEUROPSYCHOLOGICAL tests, *COGNITION disorders, *COGNITIVE testing, *MEDICAL errors
Abstract

Objective: With the increasing focus on reducing medical errors and the aging of the physician workforce has come growing concern for cognitive impairment among physicians. This study sought to establish and validate an approach to detecting neuropsychological impairment among physicians. Method: The neuropsychological test performance of 30 physicians referred clinically for neuropsychological evaluations was compared to that of 39 normal community-practicing urologists. We derived 9 key variables from the cognitive and motor tests as dependent variables. Impairment among the clinically-referred doctors was operationalized as scoring ≤5th percentile of the community physicians on at least 3, 4, 5, or 6 of the 9 variables. Using this approach, all clinically-referred physicians were classified as either "impaired" or "ambiguous." Results: A cutoff of ≥5 impaired test scores provided the best balance among competing models. Using this criterion, 14 of the clinically-referred doctors (46%) were impaired and 16 remained ambiguous. The impaired physicians: (1) were older, (2) were more often suspected of having a neurodegenerative disorder, and (3) were more likely to have discontinued practicing medicine. These findings serve as initial validation of our methodology. Conclusions: Using conservative criteria derived from normal community physicians, we could identify a substantial subgroup of clinically-referred physicians who are unambiguously neurocognitively impaired. Replication and refinement of our method with larger samples are recommended, as are the development of specialty-specific criteria for impairment. [ABSTRACT FROM AUTHOR]

Published
2020
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30. Influence of sex differences in interpreting learning and memory within a clinical sample of older adults.

Author

Brunet, Hannah E., Caldwell, Jessica Z. K., Brandt, Jason, and Miller, Justin B.

Subjects
OLDER people, VERBAL memory, VERBAL learning, MEMORY disorders, MEMORY testing, HUMAN sexuality, MEMORY
Abstract

Sex is an important factor to consider when evaluating memory with older adults. This present study aimed to examine sex differences in memory within a clinical sample of older adults (N = 1084). Raw learning and recall scores on the Hopkins Verbal Learning Test, Revised (HVLT-R) and Brief Visuospatial Memory Test, Revised (BVMT-R) were compared between sexes within the entire sample and cohorts stratified by age. Within the entire sample, women outperformed men in HVLT-R learning and recall, and there were no sex differences in BVMT-R performance. These sex differences, however, were absent or reversed for those with impaired HVLT-R performance and functional deficits, indicating that women retain an early advantage in verbal memory, which is lost with greater indication of disease severity. These findings indicate that women retain an advantage in verbal learning and memory, at least before significant levels of impairment, within a sample of older adults seen at an outpatient neurology clinic, which may have implications for diagnosing memory disorders. [ABSTRACT FROM AUTHOR]

Published
2020
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31. Metabolic Syndrome and Cognitive Trajectories in the Framingham Offspring Study.

Author

Bangen, Katherine J., Armstrong, Nicole M., Au, Rhoda, Gross, Alden L., and Brandt, Jason

Subjects
METABOLIC syndrome, ALZHEIMER'S disease, NEUROPSYCHOLOGICAL tests, COGNITIVE ability, RESEARCH, AGE distribution, RESEARCH methodology, COGNITION, EVALUATION research, MEDICAL cooperation, SEX distribution, COMPARATIVE studies, SURVIVAL analysis (Biometry), APOLIPOPROTEINS, RESEARCH funding, SMOKING, EDUCATIONAL attainment, LONGITUDINAL method
Abstract

Metabolic syndrome (MetS) has been linked to increased risk of developing cognitive impairment and dementia including Alzheimer's disease. It remains unclear whether and at what stage in the adult lifespan MetS and its components begin to alter the trajectory of cognitive performance. In the present study, 2,892 Framingham Offspring participants completed health assessments every four years since 1971 and underwent repeat neuropsychological testing from 1999 to 2014. We estimated the associations of levels and changes in cognitive trajectories with hazard of MetS using a joint growth/survival model. All models were adjusted for baseline age, sex, education, and smoking status. Findings showed that both mid-life and late-life MetS were associated with lower level of cognitive functioning but not cognitive trajectories. Associations were strongest among those who were nondemented and apolipoprotein (APOE) ɛ4 noncarriers. In addition, individuals with the most rapid cognitive decline were more likely to have MetS. The pattern of results showed that associations between MetS and cognition varied, depending upon whether the sample was stratified by genetic and cognitive status and whether we considered cognitive performance as a continuous variable or examined categorical groupings. Given that mid-life MetS was associated with poorer cognition at age 55, cognitive changes may occur early during the MetS process. Our findings suggest that those with MetS are at greater risk of dementia given their lower level of cognitive functioning and also suggest that MetS may be a risk factor for decline in the absence of known risk factors including the APOEɛ4 allele. [ABSTRACT FROM AUTHOR]

Published
2019
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38. Association between serotonin denervation and resting-state functional connectivity in mild cognitive impairment

Author

Barrett, Frederick S., primary, Workman, Clifford I., additional, Sair, Haris I., additional, Savonenko, Alena V., additional, Kraut, Michael A., additional, Sodums, Devin J., additional, Joo, Jin J., additional, Nassery, Najlla, additional, Marano, Christopher M., additional, Munro, Cynthia A., additional, Brandt, Jason, additional, Zhou, Yun, additional, Wong, Dean F., additional, and Smith, Gwenn S., additional

Published
2017
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39. Health-Care Use and Cost in Dementia Caregivers: Longitudinal Results from the Predictors Caregiver Study

Author

Zhu, Carolyn W., Scarmeas, Nikolaos, Ornstein, Katherine, Albert, Marilyn, Brandt, Jason, Blacker, Deborah, Sano, Mary, and Stern, Yaakov

Subjects
Medical care, Cost of, Caregivers, Dementia, Alzheimer's disease
Abstract

OBJECTIVE: To examine the effects of caregiver and patient characteristics on caregivers' medical care use and cost. METHODS: One hundred forty-seven caregiver/patient dyads were followed annually for 6 years in three academic Alzheimer's disease centers in the United States. Logistic, negative binomial, and generalized linear mixed models were used to examine overall effects of caregiver/patient characteristics on caregivers' hospitalizations, doctor visits, outpatient tests and procedures, and prescription and over-the-counter medications. RESULTS: Patients' comorbid conditions and dependence were associated with increased health-care use and costs of caregivers. Increases in caregiver depressive symptoms are associated with increases in multiple domains of caregivers' health-care use and costs. DISCUSSION: Findings suggest expanding our focus on dementia patients to include family caregivers to obtain a fuller picture of effects of caregiving. Primary care providers should integrate caregivers' needs in health-care planning and delivery. Clinical interventions that treat patients and caregivers as a whole will likely achieve the greatest beneficial effects.

Published
2015
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40. Neuropsychological predictors of patient-reported cognitive decline after deep brain stimulation in Parkinson's disease.

Author

Mills, Kelly A., Donohue, Kristyn, Swaminathan, Aathman, Leoutsakos, Jeannie-Marie, Smith, Gwenn, and Brandt, Jason

Subjects
PARKINSON'S disease, DEEP brain stimulation, IMPULSE control disorders, VERBAL memory, THERAPEUTIC complications, PROBLEM solving
Abstract

Background: Deep brain stimulation (DBS) is effective for treatment of motor complications of dopaminergic therapy in Parkinson's disease (PD) but occasionally has been associated with multidomain cognitive decline. Patient- and caregiver-reported cognitive decline are clinically meaningful and increasingly recognized as important to consider when evaluating therapeutic interventions for PD. Objective: The objective was to assess presurgical neuropsychological and clinical factors associated with PD patient- and caregiver-reported cognitive decline in two or more domains after DBS. Method: A single telephone survey was used to assess patient- and caregiver-reported cognitive decline in five domains at both one and four months after DBS surgery. Decline in two or more domains was considered multidomain cognitive decline (MDCD). Baseline demographic, clinical, and neuropsychological factors were compared in those with or without MDCD. Preoperative neuropsychological measures were evaluated as risk factors and regressed on the presence of MDCD, with demographic covariates, using multiple logistic regression. Results: Preoperative performance in verbal recognition memory, language knowledge, and verbal processing decline were associated with postoperative, patient-reported MDCD in the first four weeks. MDCD at four months after DBS was associated with worse preoperative verbal reasoning, verbal recall, and semantic verbal fluency. Caregiver-reported MDCD one month after DBS was associated with poorer baseline verbal memory recognition accuracy/discriminability, visuospatial problem solving, and constructional praxis. Conclusion: Poor presurgical performance in verbal memory recognition, language processing, and visuospatial performance is associated with patient- or caregiver-reported decline following DBS surgery. Posterior cortical dysfunction seems to portend significant self-reported cognitive decline following deep brain stimulation. [ABSTRACT FROM AUTHOR]

Published
2019
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45. Using Neuropsychological Process Scores to Identify Subtle Cognitive Decline and Predict Progression to Mild Cognitive Impairment.

Author

Alzheimer’s Disease Neuroimaging Initiative, Brandt, Jason, Thomas, Kelsey R., Edmonds, Emily C., Bondi, Mark W., Eppig, Joel, Salmon, David P., and Alzheimer’s Disease Neuroimaging Initiative

Subjects
*MILD cognitive impairment, *NEUROPSYCHOLOGICAL tests, *ALZHEIMER'S disease, *DEMENTIA, *EARLY diagnosis, *DISEASE progression, *RESEARCH, *RESEARCH methodology, *EVALUATION research, *MEDICAL cooperation, *PSYCHOLOGICAL tests, *COMPARATIVE studies, *RESEARCH funding, *PROPORTIONAL hazards models, *DISEASE complications
Abstract

Background: We previously operationally-defined subtle cognitive decline (SCD) in preclinical Alzheimer's disease (AD) using total scores on neuropsychological (NP) tests. NP process scores (i.e., provide information about how a total NP score was achieved) may be a useful tool for identifying early cognitive inefficiencies prior to objective impairment seen in mild cognitive impairment (MCI) and dementia.Objective: We aimed to integrate process scores into the SCD definition to identify stages of SCD and improve early detection of those at risk for decline.Methods: Cognitively "normal" participants from the Alzheimer's Disease Neuroimaging Initiative were classified as "early" SCD (E-SCD; >1 SD below norm-adjusted mean on 2 process scores or on 1 process score plus 1 NP total score), "late" SCD (L-SCD; existing SCD criteria of >1 SD below norm-adjusted mean on 2 NP total scores in different domains), or "no SCD" (NC). Process scores considered in the SCD criteria were word-list intrusion errors, retroactive interference, and learning slope. Cerebrospinal fluid AD biomarkers were used to examine pathologic burden across groups.Results: E-SCD and L-SCD progressed to MCI 2.5-3.4 times faster than the NC group. Survival curves for E-SCD and L-SCD converged at 7-8 years after baseline. The combined (E-SCD+L-SCD) group had improved sensitivity to detect progression to MCI relative to L-SCD only. AD biomarker positivity increased across NC, SCD, and MCI groups.Conclusions: Process scores can be integrated into the SCD criteria to allow for increased sensitivity and earlier identification of cognitively normal older adults at risk for decline prior to frank impairment on NP total scores. [ABSTRACT FROM AUTHOR]

Published
2018
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50. Subjective Cognitive Decline Is Associated With Altered Default Mode Network Connectivity in Individuals With a Family History of Alzheimer’s Disease

Author

Verfaillie, Sander C.J., Pichet Binette, Alexa, Vachon-Presseau, Etienne, Tabrizi, Shirin, Savard, Mélissa, Bellec, Pierre, Ossenkoppele, Rik, Scheltens, Philip, van der Flier, Wiesje M., Breitner, John C.S., Villeneuve, Sylvia, Aisen, Paul, Anthal, Elena, Appleby, Melissa, Ayranci, Gülebru, Barkun, Alan, Beaudry, Thomas, Bellec, Pierre, Benbouhoud, Fatiha, Bohbot, Veronique, Brandt, Jason, Breitner, John, Carmo, Leopoldina, Carrier Charles, Edouard, Chakravarty, Mallar, Cheewakriengkrai, Laksanun, Collins, Louis, Courcot, Blandine, Couture, Doris, Craft, Suzanne, Cuello, Claudio, Dadar, Mahsa, Dansereau, Christian, DasSamir, Marina, Dauar-Tedeschi, Dea, Doris, Debacker, Clement, Desautels, Rene, Dubuc, Sylvie, Duclair, Guerda, Dufour, Marianne, Eisenberg, Mark, El-Khoury, Rana, Etienne, Pierre, Evans, Alan, Faubert, Anne-Marie, Ferdinand, Fabiola, Fonov, Vladimir, Fontaine, David, Frappier, Josée, Joanne, Frenette, Gagne, Guylaine, Gauthier, Serge, Gervais, Valérie, Giles, Renuka, Gonneaud, Julie, Gordon, Renee, Hoge, Rick, Hyman, Bradley, Ituria-Medina, Yasser, Jack, Clifford, Kat, Justin, Kazazian, Christina, Khachaturian, Zaven, Knopman, David, Kostopoulos, Penelope, Labonte, Anne, Lafaille-Magnan, Marie-Elyse, Lee, Tanya, Leoutsakos, Jeannie-Marie, Lepage, Claude, Leppert, Illana, Madjar, Cécile, Mahar, Laura, Maillet, David, Maltais, Jean-Robert, Mathieu, Axel, Mathotaarachchi, Sulantha, Maultaup, Gerhard, Mayrand, Ginette, Meyer, Pierre-François, Michaud, Diane, Miron, Justin, Montine, Thomas, Morris, John, Münter, Lisa-Marie, Nair, Vasavan, Near, Jamie, Newbold-Fox, Holly, Orban, Pierre, Page, Véronique, Pascoal, Tharick, Petkova, Mirela, Picard, Cynthia, Pichet Binette, Alexa, Pogossova, Galina, Poirier, Judes, Pruessner, Jens, Rajah, Natasha, Rioux, Pierre, Rosa-Neto, Pedro, Sager, Mark, Saint-Fort, Eunice Farah, Savard, Mélissa, Sperling, Reisa, Tabrizi, Shirin, Tam, Angela, Tardif, Christine, Tariot, Pierre, Teigner, Eduard, Theroux, Louise, Thomas, Ronald, Toussaint, Paule-Joanne, Tremblay-Mercier, Jennifer, Tuwaig, Miranda, Vallee, Isabelle, Venugopalan, Vinod, Verfaillie, Sander, Villeneuve, Sylvia, Vogel, Jacob, Wan, Karen, Wang, Seqian, and Yu, Elsa

Abstract

Both subjective cognitive decline (SCD) and a family history of Alzheimer’s disease (AD) portend risk of brain abnormalities and progression to dementia. Posterior default mode network (pDMN) connectivity is altered early in the course of AD. It is unclear whether SCD predicts similar outcomes in cognitively normal individuals with a family history of AD.

Published
2018
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