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2. The interaction of thrombocytopenia, hemorrhage, and platelet transfusion in venoarterial extracorporeal membrane oxygenation: a multicenter observational study

Author

Raasveld, Senta Jorinde, van den Oord, Claudia, Schenk, Jimmy, van den Bergh, Walter M., Oude Lansink - Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, Lorusso, Roberto, Delnoij, Thijs S. R., Dos Reis Miranda, Dinis, Scholten, Erik, Taccone, Fabio Silvio, Dauwe, Dieter F., De Troy, Erwin, Hermans, Greet, Pappalardo, Federico, Fominskiy, Evgeny, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, Donker, Dirk W., Meuwese, Christiaan L., De Bakker, Martin, Reddi, Benjamin, Henriques, José P. S., Broman, Lars Mikael, Dongelmans, Dave A., and Vlaar, Alexander P. J.

Published
2023
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8. Plasma Transfusion and Procoagulant Product Administration in Extracorporeal Membrane Oxygenation: A Secondary Analysis of an International Observational Study on Current Practices

Author

van Haeren, Maite M.T., Raasveld, Senta Jorinde, Karami, Mina, Miranda, Dinis Dos Reis, Mandigers, Loes, Dauwe, Dieter F., De Troy, Erwin, Pappalardo, Federico, Fominskiy, Evgeny, van den Bergh, Walter M., Oude Lansink-Hartgring, Annemieke, van der Velde, Franciska, Maas, Jacinta J., van de Berg, Pablo, de Haan, Maarten, Donker, Dirk W., Meuwese, Christiaan L., Taccone, Fabio Silvio, Peluso, Lorenzo, Lorusso, Roberto, Delnoij, Thijs S.R., Scholten, Erik, Overmars, Martijn, Ivancan, Višnja, Bojčić, Robert, de Metz, Jesse, van den Bogaard, Bas, de Bakker, Martin, Reddi, Benjamin, Hermans, Greet, Broman, Lars Mikael, Henriques, José P.S., Schenk, Jimmy, Vlaar, Alexander P.J., and Müller, Marcella C.A.

Published
2023
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9. Transfusion practice in patients receiving VV ECMO (PROTECMO): a prospective, multicentre, observational study

Author

Martucci, Gennaro, Arcadipane, Antonio, Pesenti, Antonio, Grasselli, Giacomo, Brioni, Matteo, De Pascale, Gennaro, Montini, Luca, Giani, Marco, Foti, Giuseppe, Bosa, Linda, Curcio, Pierfrancesco, Fanelli, Vito, Garofalo, Eugenio, Martin-Villen, Luis, Garcìa-Álvarez, Raquel, Lopez Sanchez, Marta, Principe, Nuno, Chica Saez, Violeta, Chico, Juan Ignacio, Gomez, Vanesa, Colomina-Climent, Joaquin, Riera, Jordi, Pacheco, Andres Francisco, Gorjup, Vojka, Goutay, Julien, Thibault, Duburcq, Szułdrzyński, Konstanty, Eller, Philipp, Lobmeyr, Elisabeth, Schellongowski, Peter, Schmidt, Matthieu, Combes, Alain, Lorusso, Roberto, Mariani, Silvia, Ranieri, Marco V., Suk, Pavel, Maly, Michal, Balik, Martin, Forestier, Jakob, Broman, Lars Mikael, Rizzo, Monica, Tuzzolino, Fabio, Tanaka, Kenichi, Holsworth, Tyler, Trethowan, Brian, Serra, Alexis, Agerstrand, Cara, Brodie, Dan, Cavayas, Yiorgos Alexandros, Tabatabai, Ali, Menaker, Jay, Galvagno, Samuel, Gannon, Whitney D., Rice, Todd W., Grandin, Wilson E., Nunez, Jose, Cheplic, Collette, Ramanan, Raj, Rivosecchi, Ryan, Cho, Young-Jae, Buabbas, Sarah, Jeon, Kyeongman, Kwan, Ming Chit, Sallam, Hend, Villanueva, Joy Ann, Aliudin, Jeffrey, Ait Hssain, Ali, Hoshino, Kota, Hara, Yoshitaka, Ramanathan, Kollengode, Maclaren, Graeme, Buscher, Hergen, Hssain, Ali Ait, Duburcq, Thibault, Gannon, Whitney D, Chico, Juan I, Broman, Lars M, Ranieri, Marco V, and Brodie, Daniel

Published
2023
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10. In-hospital and 6-month outcomes in patients with COVID-19 supported with extracorporeal membrane oxygenation (EuroECMO-COVID): a multicentre, prospective observational study

Author

Lorusso, Roberto, De Piero, Maria Elena, Mariani, Silvia, Di Mauro, Michele, Folliguet, Thierry, Taccone, Fabio Silvio, Camporota, Luigi, Swol, Justyna, Wiedemann, Dominik, Belliato, Mirko, Broman, Lars Mikael, Vuylsteke, Alain, Kassif, Yigal, Scandroglio, Anna Mara, Fanelli, Vito, Gaudard, Philippe, Ledot, Stephane, Barker, Julian, Boeken, Udo, Maier, Sven, Kersten, Alexander, Meyns, Bart, Pozzi, Matteo, Pedersen, Finn M, Schellongowski, Peter, Kirali, Kaan, Barrett, Nicholas, Riera, Jordi, Mueller, Thomas, Belohlavek, Jan, Lo Coco, Valeria, Van der Horst, Iwan C C, Van Bussel, Bas C T, Schnabel, Ronny M, Delnoij, Thijs, Bolotin, Gil, Lorini, Luca, Schmiady, Martin O, Schibilsky, David, Kowalewski, Mariusz, Pinto, Luis F, Silva, Pedro E, Kornilov, Igor, Blandino Ortiz, Aaron, Vercaemst, Leen, Finney, Simon, Roeleveld, Peter P, Di Nardo, Matteo, Hennig, Felix, Antonini, Marta Velia, Davidson, Mark, Jones, Tim J, Staudinger, Thomas, Mair, Peter, Kilo, Juliane, Krapf, Christoph, Erbert, Kathrin, Peer, Andreas, Bonaros, Nikolaos, Kotheletner, Florian, Krenner Mag, Niklas, Shestakova, Liana, Hermans, Greet, Dauwe, Dieter, Meersseman, Philippe, Stockman, Bernard, Nobile, Leda, Lhereux, Olivier, Nrasseurs, Alexandre, Creuter, Jacques, De Backer, Daniel, Giglioli, Simone, Michiels, Gregoire, Foulon, Pierre, Raes, Matthias, Rodrigus, Inez, Allegaert, Matthias, Jorens, Philippe, Debeucklare, Gerd, Piagnerelli, Michael, Biston, Patrick, Peperstraete, Harlinde, Vandewiele, Komeel, Germay, Olivier, Vandeweghe, Dimitri, Havrin, Sven, Bourgeois, Marc, Lagny, Marc-Gilbert, Alois, Genette, Lavios, Nathalie, Misset, Benoit, Courcelle, Romain, Timmermans, Philippe J, Yilmaz, Alaaddin, Vantomout, Michiel, Lehaen, Jerone, Jassen, Ame, Guterman, Herbert, Strauven, Maarten, Lormans, Piet, Verhamme, Bruno, Vandewaeter, catherine, Bonte, Frederik, Vionne, Dominique, Balik, Martin, Blàha, Jan, Lips, Michal, Othal, Michal, Bursa, Filip, Spacek, Radim, Christensen, Steffen, Jorgensen, Vibeke, Sorensen, Marc, Madsen, Soren A, Puss, Severin, Beljantsev, Aleksandr, Saiydoun, gabriel, Fiore, Antonio, Colson, Pascal, Bazalgette, Florian, Capdevila, Xavier, Kollen, Sebastien, Muller, Laurent, Obadia, Jean-Francois, Dubien, Pierre-Yves, Ajrhourh, Lucrezia, Guinot, Pierre G, Zarka, Jonathan, Besserve, Patricia, Malfertheiner, Maximilian V, Dreier, Esther, Heinze, Birgit, Akhyari, Payam, Lichtenberg, Artur, Aubin, Hug, Assman, Alexander, Saeed, Diyar, Thiele, Holger, Baumgaertel, Matthias, Schmitto, Jan D, Ruslan, Natanov, Haverich, Axel, Thielmann, Matthias, Brenner, Thorsten, Ruhpawar, Arjang, Benk, Christoph, Czerny, Martin, Staudacher, Dawid L, Beyersdorf, Fridhelm, Kalbhenn, Johannes, Henn, Philipp, Popov, Aron-Frederik, Iuliu, Torje, Muellenbach, Ralf, Reyher, Christian, Rolfes, Caroline, Lotz, Gosta, Sonntagbauer, Michael, Winkels, Helen, Fichte, Julia, Stohr, Robert, Kalverkamp, Sebastian, Karagiannidis, Christian, Schafer, Simone, Svetlitchny, Alexei, Hopf, Hans-Bernd, Jarczak, Dominik, Groesdonk, Heinirich, Rommer, Magdalena, Hirsch, Jan, Kaehny, Christian, Soufleris, Dimitros, Gavriilidis, Georgios, Pontikis, Kostantinos, Kyriakopoulou, Magdalini, Kyriakoudi, Anna, O'Brien, Serena, Conrick-Martin, Ian, Carton, Edmund, Makhoul, Maged, Ben-Ari, Josef, Hadash, Amir, Kogan, Alexander, Kassif Lerner, Reut, Abu-Shakra, Anas, Matan, Moshe, Balawona, Ahmad, Kachel, Erez, Altshuler, Roman, Galante, Ori, Fuchs, Lior, Almog, Yaniv, Ishay, Yaron S, Lichter, Yael, Gal-oz, Amir, Carmi, Uri, Nini, Asaph, Soroksky, Arie, Dekel, Hagi, Rozman, Ziv, Tayem, Emad, Ilgiyaev, Eduard, Hochman, Yuval, Miltau, daniel, Rapoport, Avigal, Eden, Arieh, Kompanietz, Dmitry, Yousif, Michael, Golos, Miri, Grazioli, Lorenzo, Ghitti, Davide, Loforte, Antonio, Di Luca, Daniela, Baiocchi, Massimo, Pacini, Davide, Cappai, Antioco, Meani, Paolo, Mondino, Michele, Russo, Claudio F, Ranucci, Marco, Fina, Dario, Cotza, Marco, Ballotta, Andrea, Landoni, Giovanni, Nardelli, Pasquale, Fominski, Eygeny V, Brazzi, Luca, Montrucchio, Giorgia, Sales, Gabriele, Simonetti, Umberto, Livigni, Sergio, Silengo, Daniela, Arena, Giulia, Sovatzis, Stefania S, Degani, Antonella, Riccardi, Mariachiara, Milanesi, Elisa, Raffa, Giuseppe, Martucci, Gennaro, Arcadipane, Antonio, Panarello, Giovanna, Chiarini, Giovanni, Cattaneo, Sergio, Puglia, Carmine, Benussi, Stefano, Foti, Giuseppe, Giani, Marco, Bombino, Michela, Costa, Maria Cristina, Rona, Roberto, Avalli, Leonello, Donati, Abele, Carozza, Roberto, Gasparri, Francesco, Carsetti, Andrea, Picichè, Marco, Marinello, Anna, Danzi, Vinicio, Zanin, Anita, Condello, Ignazio, Fiore, Flavio, Moscarelli, Marco, Nasso, Giuseppe, Speziale, Giuseppe, Sandrelli, Luca, Montalto, Andrea, Musumeci, Francesco, Circelli, Alessandro, Russo, Emanuele, Agnoletti, Vanni, Rociola, Ruggero, Milano, Aldo D, Pilato, Emanuele, Comentale, Giuseppe, Montisci, Andrea, Alessandri, Francesco, Tosi, Antonella, Pugliese, Francesco, Giordano, Giovanni, Carelli, Simone, Grieco, Domenico L, Dell'Anna, Antonio M, Antonelli, Massimo, Ramoni, Enrico, Zulueta, Josè, Del Giglio, Mauro, Petracca, Sebastiano, Bertini, Pietro, Guarracino, Fabio, De Simone, Luigi, Angeletti, Paolo M, Forfori, Francesco, Taraschi, Francesco, Quintiliani, Veronica N, Samalavicius, Robertas, Jankuviene, Agne, Scupakova, Nadezda, Urbonas, Karolis, Kapturauskas, Juozas, Soerensen, Gro, Suwalski, Piotr, Linhares Santos, Luis, Marques, Ana, Miranda, Marisa, Teixeira, Sonia, Salgueiro, Andrea, Pereira, Filipe, Ketskalo, Michail, Tsarenko, Sergey, Shilova, Alexandra, Afukov, Ivan, Popugaev, Konstantin, Minin, Sergei, Shelukhin, Daniil, Malceva, Olga, Gleb, Moroz, Skopets, Alexander, Kornelyuk, Roman, Kulikov, Alexandr, Okhrimchuk, Vadim, Turchaninov, Alexandr, Petrushin, Maxim, Sheck, Anastasia, Mekulov, Akhmed, Ciryateva, Svetlana, Urusov, Dmitry, Gorjup, Vojka, Golicnik, Alenka, Goslar, Tomaz, Ferrer, Ricard, Martinez-Martinez, Maria, Argudo, Eduard, Palmer, Neiser, De Pablo Sanchez, Raul, Juan Higuera, Lucas, Arnau Blasco, Lucas, Marquez, Josè A, Sbraga, Fabrizio, Fuset, Mari Paz, De Gopegui, Pablo Ruiz, Claraco, Luis M, De Ayala, Josè A, Peiro, Maranta, Ricart, Pilar, Martinez, Sergio, Chavez, Fernando, Fabra, Marc, Sandoval, elena, Toapanta, David, Carraminana, Albert, Tellez, Adrian, Ososio, Jeysson, Milan, Pablo, Rodriguez, Jorge, Andoni, Garcia, Gutierrez, Carola, Perez de la Sota, Enrique, Eixeres-Esteve, Andrea, Garcia-Maellas, Maria Teresa, Gutierrez-Gutierrez, Judit, Arboleda-Salazar, Rafael, Santa Teresa, Patricia, Jaspe, Alexis, Garrido, Alberto, Castaneda, Galo, Alcantara, Sara, Martinez, Nuria, Perez, Marina, Villanueva, Hector, Vidal Gonzalez, Anxela, Paez, Juan, Santon, Arnoldo, Perez, Cesar, Lopez, Marta, Rubio Lopez, Maria Isabel, Gordillo, Antonio, Naranjo-Izurieta, Jose, Munoz, Javier, Alcalde, Immaculada, Onieva, Fernando, Gimeno Costa, Ricardo, Perez, Francisco, Madrid, Isabel, Gordon, Monica, Albacete Moreno, Carlos L, Perez, Daniel, Lopez, Nayara, Martinenz, Domingo, Blanco-Schweizer, Pablo, Diez, Cristina, Perez, David, Prieto, Ana, Renedo, Gloria, Bustamante, Elena, Cicuendez, Ramon, Citores, Rafael, Boado, Victoria, Garcia, Katherine, Voces, Roberto, Domezain, Monica, Nunez Martinez, Jose Maria, Vicente, Raimundo, Martin, David, Andreu, Antonio, Gomez Casal, Vanesa, Chico, Ignacio, Menor, Eva Maria, Vara, Sabela, Gamacho, Jose, Perez-Chomon, Helen, Javier Gonzales, Francisco, Barrero, Irene, Martin-Villen, Luis, Fernandez, Esperanza, Mendoza, Maria, Navarro, Joaquin, Colomina Climent, Joaquin, Gonzales-Perez, Alfredo, Muniz-Albaceita, Guillermo, Amado, Laura, Rodriguez, Raquel, Ruiz, Emilio, Eiras, Maria, Grins, Edgars, Magnus, Rosen, Kanetoft, Mikael, Eidevald, Marcus, Watson, Pia, Vogt, Paul R, Steiger, Peter, Aigner, Tobias, Weber, Alberto, Grunefelder, Jurg, Kunz, Martin, Grapow, Martin, Aymard, Thierry, Reser, Diana, Agus, Gianluca, Consiglio, Jolanda, Haenggi, Matthias, Hansjoerg, Jenni, Iten, Manuela, Doeble, Thomas, Zenklusen, Urs, Bechtold, Xavier, Faedda, Giovanni, Iafrate, Manuel, Rohjer, Amanda, Bergamaschi, Layla, Maessen, Jos, Reis Miranda, Dinis, Endeman, H, Gommers, D, Meuwese, C, Maas, Jacinta, Van Gijlswijk, MJ, Van Berg, RN, Candura, Dario, Van der Linden, Marcel, Kant, Merijin, Van der Heijden, JJ, Scholten, Eric, Van Belle-van Haren, Nicole, Lagrand, WK, Vlaar, Alexander P, De Jong, Syste, Cander, Basar, Sargin, Murat, Ugur, Murat, Kaygin, Mehmet A, Daly, Kathleen, Agnew, Nicola, Head, Laura, Kelly, Laura, Anoma, Gunawardena, Russell, Clare, Aquino, Verna, Scott, Ian, Flemming, Lucy, Gillon, Stuart, Moore, Olivia, Gelandt, Elton, Auzinger, George, Patel, Sameer, and Loveridge, Robert

Published
2023
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11. Evolution of distal limb perfusion management in adult peripheral venoarterial extracorporeal membrane oxygenation with femoral artery cannulation

Author

Simons, Jorik, primary, Mees, Barend, additional, MacLaren, Graeme, additional, Fraser, John F, additional, Zaaqoq, Akram M, additional, Cho, Sung-Min, additional, Patel, Bhavesh M, additional, Brodie, Daniel, additional, Bělohlávek, Jan, additional, Belliato, Mirko, additional, Jung, Jae-Seung, additional, Salazar, Leonardo, additional, Meani, Paolo, additional, Mariani, Silvia, additional, Di Mauro, Michele, additional, Yannopoulos, Demetris, additional, Broman, Lars Mikael, additional, Chen, Yih-Sharng, additional, Riera, Jordi, additional, van Mook, Walther NKA, additional, and Lorusso, Roberto, additional

Published
2024
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18. Venovenous extracorporeal membrane oxygenation drainage cannula performance: From generalized to patient-averaged vessel model.

Author

Parker, Louis P., Fiusco, Francesco, Rorro, Federico, Svensson Marcial, Anders, Brismar, Torkel B., Broman, Lars Mikael, and Prahl Wittberg, Lisa

Subjects
EXTRACORPOREAL membrane oxygenation, OXYGENATORS, MEDICAL drainage, CATHETERS, LARGE eddy simulation models, ADULT respiratory distress syndrome
Abstract

Venovenous extracorporeal membrane oxygenation is used for respiratory support in the most severe cases of acute respiratory distress syndrome. Blood is drained from the large veins, oxygenated in an artificial lung, and returned to the right atrium (RA). In this study, we have used large eddy simulations to simulate a single-stage "lighthouse" drainage cannula in a patient-averaged model of the large veins and RA, including the return cannula. We compared the results with previous experimental and numerical studies of these cannulas in idealized tube geometries. According to the simulations, wall proximity at the drainage holes and the presence of the return cannula greatly increased drainage through the tip (33% at 5 L/min). We then simulated a multi-stage device in the same patient-averaged model, showing similar recirculation performance across the range of extracorporeal membrane oxygenation (ECMO) flow rates compared to the lighthouse cannula. Mean and maximum time-averaged wall shear stress were slightly higher for the lighthouse design. At high ECMO flow rates, the multi-stage device developed a negative caval pressure, which may be a cause of drainage obstruction in a clinical environment. Finally, through calculation of the energy spectra and vorticity field, we observed ring-like vortices inside the cannula originating from the side holes, most prominent in the proximal position. Our work highlights the important differences between a patient-derived and simplified venous model, with the latter tending to underestimate tip drainage. We also draw attention to the different dynamics of single-stage and multistage drainage cannulas, which may guide clinical use. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Survival and Long-Term Functional Status of COVID-19 Patients Requiring Prolonged ECMO Support

Author

Martínez Martínez, María, primary, Schmidt, Matthieu, additional, Broman, Lars Mikael, additional, Roncon-Albuquerque, Roberto, additional, Langouet, Elise, additional, Campos, Isabel, additional, Argudo, Eduard, additional, Domènech Vila, Josep Maria, additional, Martín Sastre, Sara, additional, Gallart, Elisabet, additional, Ferrer, Ricard, additional, Combes, Alain, additional, and Riera, Jordi, additional

Published
2023
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20. Outcomes of Extracorporeal Membrane Oxygenation in COVID-19–Induced Acute Respiratory Distress Syndrome: An Inverse Probability Weighted Analysis

Author

Raasveld, Senta Jorinde, Taccone, Fabio Silvio, Broman, Lars Mikael, Hermans, Greet, Meersseman, Philippe, Quintana Diaz, Manuel, Delnoij, Thijs S. R., van de Poll, Marcel, Gouvea Bogossian, Elisa, van Baarle, Floor L. F., Durak, Koray, Zayat, Rashad, Oude Lansink-Hartgring, Annemieke, Meuwese, Christiaan L., van der Heijden, Joris J., de Troy, Erwin, Dauwe, Dieter, Scholten, Erik, van der Velde, Franciska, Maas, Jacinta J., Dos Reis Miranda, Dinis, Kuijpers, Marijn, van den Brule, Judith, van den Bergh, Walter M., and Vlaar, Alexander P. J.

Published
2022
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22. Survival and Long-Term Functional Status of COVID-19 Patients Requiring Prolonged Extracorporeal Membrane Oxygenation Support.

Author

Martínez-Martínez, María, Schmidt, Matthieu, Broman, Lars Mikael, Roncon-Albuquerque Jr., Roberto, Langouet, Elise, Campos, Isabel, Argudo, Eduard, Domènech Vila, Josep Maria, Sastre, Sara Martín, Gallart, Elisabet, Ferrer, Ricard, Combes, Alain, and Riera, Jordi

Subjects
EXTRACORPOREAL membrane oxygenation, COVID-19, ADULT respiratory distress syndrome, FUNCTIONAL status, OXYGEN therapy
Abstract

Rationale: Severe cases of acute respiratory distress syndrome (ARDS) may require prolonged (>28 d) extracorporeal membrane oxygenation (ECMO). In nonresolving disease, recovery is uncertain, and lung transplant may be proposed. Objectives: This study aims to identify the variables influencing survival and to describe the functional status of these patients at 6 months. Methods: This was a retrospective, multicenter, observational cohort study including patients requiring ECMO support for coronavirus disease (COVID-19)-related ARDS for >28 days. Multivariate analysis was performed using Cox regression in preselected variables and in least absolute shrinkage and selection operator selected variables. In a post hoc analysis to account for confounders and differences in awake strategy use by centers, treatment effects of the awake strategy were estimated using an augmented inverse probability weighting estimator with robust standard errors clustered by center. Results: Between March 15, 2020 and March 15, 2021, 120 patients required ECMO for >28 days. Sixty-four patients (53.3%) survived decannulation, 62 (51.7%) were alive at hospital discharge, and 61 (50.8%) were alive at 6-month follow-up. In the multivariate analysis, age (1.09; 95% confidence interval [CI], 1.03–1.15; P = 0.002) and an awake ECMO strategy (defined as the patient being awake, cooperative, and performing rehabilitation and physiotherapy with or without invasive mechanical ventilation at any time during the extracorporeal support) (0.14; 95% CI, 0.03–0.47; P = 0.003) were found to be predictors of hospital survival. At 6 months, 51 (42.5%) patients were at home, 42 (84.3%) of them without oxygen therapy. A cutoff point of 47 ECMO days had a 100% (95% CI, 76.8–100%) sensitivity and 60% (95% CI, 44.3–73.6%) specificity for oxygen therapy at 6 months, with 100% specificity being found in 97 days. Conclusions: Patients with COVID-19 who require ECMO for >28 days can survive with nonlimiting lung impairment. Age and an awake ECMO strategy may be associated with survival. Longer duration of support correlates with need for oxygen therapy at 6 months. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Backflow at the inlet of centrifugal blood pumps enhanced by geometrical features.

Author

Rorro, Federico, Fiusco, Francesco, Broman, Lars Mikael, and Prahl Wittberg, Lisa

Subjects
CENTRIFUGAL pumps, EXTRACORPOREAL membrane oxygenation, SWIRLING flow, INLETS, BLOOD flow
Abstract

Extracorporeal life support (ECLS) includes life-saving support in severe acute cardiac and/or pulmonary failure. In the past 20 years, centrifugal pumps have become the primary choice to deliver the required blood flow. Pumps of various designs, with different approved operating ranges, are today available to clinicians. The use of centrifugal pumps in the low flow condition has been shown to increase hemolytic and thrombogenic risks of the treatment. Further, low flow operation has been associated with retrograde flow at the pump inlet. In this study, experimental and numerical methods have been applied to investigate the operating conditions and fluid dynamical mechanisms leading to reverse flow (or backflow) at the inlet. Reverse flow was predominantly observed in pumps having a top shroud covering the impeller blades, showing a relation between pump geometry and backflow. The shroud divides the pump volume above the impeller into two regions, separating the swirling reverse flow migrating toward the upper pump volute from the main flow, reducing the dissipation of the vortical structures, and allowing the swirling reverse flow to reach further in the pump inlet. At the inlet, backflow was observed as stable recirculation areas at the side of the pump inlet. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Transfusion of red blood cells in venoarterial extracorporeal membrane oxygenation: A multicenter retrospective observational cohort study

Author

Raasveld, Senta Jorinde, primary, Karami, Mina, additional, Schenk, Jimmy, additional, Dos Reis Miranda, Dinis, additional, Mandigers, Loes, additional, Dauwe, Dieter F., additional, De Troy, Erwin, additional, Pappalardo, Federico, additional, Fominskiy, Evgeny, additional, van den Bergh, Walter M., additional, Oude Lansink‐Hartgring, Annemieke, additional, van der Velde, Franciska, additional, Maas, Jacinta J., additional, van de Berg, Pablo, additional, de Haan, Maarten, additional, Donker, Dirk W., additional, Meuwese, Christiaan L., additional, Taccone, Fabio Silvio, additional, Peluso, Lorenzo, additional, Lorusso, Roberto, additional, Delnoij, Thijs S. R., additional, Scholten, Erik, additional, Overmars, Martijn, additional, Ivančan, Višnja, additional, Bojčić, Robert, additional, de Metz, Jesse, additional, van den Bogaard, Bas, additional, de Bakker, Martin, additional, Reddi, Benjamin, additional, Hermans, Greet, additional, Broman, Lars Mikael, additional, Henriques, José P. S., additional, and Vlaar, Alexander P. J., additional

Published
2023
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30. Extracorporeal membrane oxygenation for refractory cardiac arrest: a retrospective multicenter study

Author

Lunz, Dirk, Calabrò, Lorenzo, Belliato, Mirko, Contri, Enrico, Broman, Lars Mikael, Scandroglio, Anna Maria, and Patricio, Daniel

Subjects
Transplantation of organs, tissues, etc. -- Analysis, Cardiac arrest -- Analysis, Donation of organs, tissues, etc. -- Analysis, Health care industry
Abstract

Purpose The aim of this study was to assess the neurologic outcome following extracorporeal cardiopulmonary resuscitation (ECPR) in five European centers. Methods Retrospective database analysis of prospective observational cohorts of patients undergoing ECPR (January 2012-December 2016) was performed. The primary outcome was 3-month favorable neurologic outcome (FO), defined as the cerebral performance categories of 1-2. Survival to ICU discharge and the number of patients undergoing organ donation were secondary outcomes. A subgroup of patients with stringent selection criteria (i.e., age [less than or equal to] 65 years, witnessed bystander CPR, no major co-morbidity and ECMO implemented within 1 h from arrest) was also analyzed. Results A total of 423 patients treated with ECPR were included (median age 57 [48-65] years; male gender 78%); ECPR was initiated for OHCA in 258 (61%) patients. Time from arrest to ECMO implementation was 65 [48-84] min. Eighty patients (19%) had favorable neurological outcome. ICU survival was 24% (n = 102); 23 (5%) non-survivors underwent organ donation procedures. Favorable neurological outcome rate was lower (9% vs. 34%, p < 0.01) in out-of-hospital than in-hospital cardiac arrest and was significantly associated with shorter time from collapse to ECMO. The application of stringent ECPR criteria (n = 105) resulted in 38% of patients with favorable neurologic outcome. Conclusions ECPR was associated with intact neurological recovery in 19% of unselected cardiac arrest victims, with 38% favorable outcome if stringent selection criteria would have been applied., Author(s): Dirk Lunz [sup.1], Lorenzo Calabrò [sup.2] [sup.3], Mirko Belliato [sup.4], Enrico Contri [sup.4], Lars Mikael Broman [sup.5], Anna Maria Scandroglio [sup.2], Daniel Patricio [sup.3], Maximilian Malfertheiner [sup.6], Jacques Creteur [...]

Published
2020
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34. International Survey on Extracorporeal Membrane Oxygenation Transport

Author

Broman, Lars Mikael, Dirnberger, Daniel R., Malfertheiner, Maximilian V., Aokage, Toshiyuki, Morberg, Pål, Næsheim, Torvind, Pappalardo, Federico, Di Nardo, Matteo, Preston, Tom, Burrell, Aidan J.C., Daly, Ivonne, Harvey, Chris, Mason, Phillip, Philipp, Alois, Bartlett, Robert H., Lynch, William, Belliato, Mirko, and Taccone, Fabio Silvio

Published
2020
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37. Extracorporeal life support provision in COVID-19 patients - An international EuroELSO 2022 update survey

Author

Fleig, Marcel, primary, Müller, Thomas, additional, Antonini, Velia M, additional, Riera, Jordi, additional, Belliato, Mirko, additional, Broman, Lars Mikael, additional, Fowles, Jo-Anne, additional, Belohlavek, Jan, additional, Lorusso, Roberto, additional, Vercaemst, Leen, additional, Jones, Tim, additional, Roeleveld, Peter P, additional, Di Nardo, Matteo, additional, Barrett, Nicholas, additional, and Swol, Justyna, additional

Published
2023
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39. In-hospital and 6-month outcomes in patients with COVID-19 supported with extracorporeal membrane oxygenation (EuroECMO-COVID): a multicentre, prospective observational study

Author

Lorusso, Roberto, primary, De Piero, Maria Elena, additional, Mariani, Silvia, additional, Di Mauro, Michele, additional, Folliguet, Thierry, additional, Taccone, Fabio Silvio, additional, Camporota, Luigi, additional, Swol, Justyna, additional, Wiedemann, Dominik, additional, Belliato, Mirko, additional, Broman, Lars Mikael, additional, Vuylsteke, Alain, additional, Kassif, Yigal, additional, Scandroglio, Anna Mara, additional, Fanelli, Vito, additional, Gaudard, Philippe, additional, Ledot, Stephane, additional, Barker, Julian, additional, Boeken, Udo, additional, Maier, Sven, additional, Kersten, Alexander, additional, Meyns, Bart, additional, Pozzi, Matteo, additional, Pedersen, Finn M, additional, Schellongowski, Peter, additional, Kirali, Kaan, additional, Barrett, Nicholas, additional, Riera, Jordi, additional, Mueller, Thomas, additional, Belohlavek, Jan, additional, Lorusso, Roberto, additional, Lo Coco, Valeria, additional, Van der Horst, Iwan C C, additional, Van Bussel, Bas C T, additional, Schnabel, Ronny M, additional, Delnoij, Thijs, additional, Bolotin, Gil, additional, Lorini, Luca, additional, Schmiady, Martin O, additional, Schibilsky, David, additional, Kowalewski, Mariusz, additional, Pinto, Luis F, additional, Silva, Pedro E, additional, Kornilov, Igor, additional, Blandino Ortiz, Aaron, additional, Vercaemst, Leen, additional, Finney, Simon, additional, Roeleveld, Peter P, additional, Di Nardo, Matteo, additional, Hennig, Felix, additional, Antonini, Marta Velia, additional, Davidson, Mark, additional, Jones, Tim J, additional, Staudinger, Thomas, additional, Mair, Peter, additional, Kilo, Juliane, additional, Krapf, Christoph, additional, Erbert, Kathrin, additional, Peer, Andreas, additional, Bonaros, Nikolaos, additional, Kotheletner, Florian, additional, Krenner Mag, Niklas, additional, Shestakova, Liana, additional, Hermans, Greet, additional, Dauwe, Dieter, additional, Meersseman, Philippe, additional, Stockman, Bernard, additional, Nobile, Leda, additional, Lhereux, Olivier, additional, Nrasseurs, Alexandre, additional, Creuter, Jacques, additional, De Backer, Daniel, additional, Giglioli, Simone, additional, Michiels, Gregoire, additional, Foulon, Pierre, additional, Raes, Matthias, additional, Rodrigus, Inez, additional, Allegaert, Matthias, additional, Jorens, Philippe, additional, Debeucklare, Gerd, additional, Piagnarelli, Michael, additional, Biston, Patrick, additional, Peperstraete, Harlinde, additional, Vandewiele, Komeel, additional, Germay, Olivier, additional, Vandeweghe, Dimitri, additional, Havrin, Sven, additional, Bourgeois, Marc, additional, Lagny, Marc-Gilbert, additional, Alois, Genette, additional, Lavios, Nathalie, additional, Misset, Benoit, additional, Courcelle, Romain, additional, Timmermans, Philippe J, additional, Yilmaz, Alaaddin, additional, Vantomout, Michiel, additional, Lehaen, Jerone, additional, Jassen, Ame, additional, Guterman, Herbert, additional, Strauven, Maarten, additional, Lormans, Piet, additional, Verhamme, Bruno, additional, Vandewaeter, catherine, additional, Bonte, Frederik, additional, Vionne, Dominique, additional, Balik, Martin, additional, Blàha, Jan, additional, Lips, Michal, additional, Othal, Michal, additional, Bursa, Filip, additional, Spacek, Radim, additional, Christensen, Steffen, additional, Jorgensen, Vibeke, additional, Sorensen, Marc, additional, Madsen, Soren A, additional, Puss, Severin, additional, Beljantsev, Aleksandr, additional, Saiydoun, gabriel, additional, Fiore, Antonio, additional, Colson, Pascal, additional, Bazalgette, Florian, additional, Capdevila, Xavier, additional, Kollen, Sebastien, additional, Muller, Laurent, additional, Obadia, Jean-Francois, additional, Dubien, Pierre-Yves, additional, Ajrhourh, Lucrezia, additional, Guinot, Pierre G, additional, Zarka, Jonathan, additional, Besserve, Patricia, additional, Malfertheiner, Maximilian V, additional, Dreier, Esther, additional, Heinze, Birgit, additional, Akhyari, Payam, additional, Lichtenberg, Artur, additional, Aubin, Hug, additional, Assman, Alexander, additional, Saeed, Diyar, additional, Thiele, Holger, additional, Baumgaertel, Matthias, additional, Schmitto, Jan D, additional, Ruslan, Natanov, additional, Haverich, Axel, additional, Thielmann, Matthias, additional, Brenner, Thorsten, additional, Ruhpawar, Arjang, additional, Benk, Christoph, additional, Czerny, Martin, additional, Staudacher, Dawid L, additional, Beyersdorf, Fridhelm, additional, Kalbhenn, Johannes, additional, Henn, Philipp, additional, Popov, Aron-Frederik, additional, Iuliu, Torje, additional, Muellenbach, Ralf, additional, Reyher, Christian, additional, Rolfes, Caroline, additional, Lotz, Gosta, additional, Sonntagbauer, Michael, additional, Winkels, Helen, additional, Fichte, Julia, additional, Stohr, Robert, additional, Kalverkamp, Sebastian, additional, Karagiannidis, Christian, additional, Schafer, Simone, additional, Svetlitchny, Alexei, additional, Hopf, Hans-Bernd, additional, Jarczak, Dominik, additional, Groesdonk, Heinirich, additional, Rommer, Magdalena, additional, Hirsch, Jan, additional, Kaehny, Christian, additional, Soufleris, Dimitros, additional, Gavriilidis, Georgios, additional, Pontikis, Kostantinos, additional, Kyriakopoulou, Magdalini, additional, Kyriakoudi, Anna, additional, O'Brien, Serena, additional, Conrick-Martin, Ian, additional, Carton, Edmund, additional, Makhoul, Maged, additional, Ben-Ari, Josef, additional, Hadash, Amir, additional, Kogan, Alexander, additional, Kassif Lerner, Reut, additional, Abu-Shakra, Anas, additional, Matan, Moshe, additional, Balawona, Ahmad, additional, Kachel, Erez, additional, Altshuler, Roman, additional, Galante, Ori, additional, Fuchs, Lior, additional, Almog, Yaniv, additional, Ishay, Yaron S, additional, Lichter, Yael, additional, Gal-oz, Amir, additional, Carmi, Uri, additional, Nini, Asaph, additional, Soroksky, Arie, additional, Dekel, Hagi, additional, Rozman, Ziv, additional, Tayem, Emad, additional, Ilgiyaev, Eduard, additional, Hochman, Yuval, additional, Miltau, daniel, additional, Rapoport, Avigal, additional, Eden, Arieh, additional, Kompanietz, Dmitry, additional, Yousif, Michael, additional, Golos, Miri, additional, Grazioli, Lorenzo, additional, Ghitti, Davide, additional, Loforte, Antonio, additional, Di Luca, Daniela, additional, Baiocchi, Massimo, additional, Pacini, Davide, additional, Cappai, Antioco, additional, Meani, Paolo, additional, Mondino, Michele, additional, Russo, Claudio F, additional, Ranucci, Marco, additional, Fina, Dario, additional, Cotza, Marco, additional, Ballotta, Andrea, additional, Landoni, Giovanni, additional, Nardelli, Pasquale, additional, Fominski, Eygeny V, additional, Brazzi, Luca, additional, Montrucchio, Giorgia, additional, Sales, Gabriele, additional, Simonetti, Umberto, additional, Livigni, Sergio, additional, Silengo, Daniela, additional, Arena, Giulia, additional, Sovatzis, Stefania S, additional, Degani, Antonella, additional, Riccardi, Mariachiara, additional, Milanesi, Elisa, additional, Raffa, Giuseppe, additional, Martucci, Gennaro, additional, Arcadipane, Antonio, additional, Panarello, Giovanna, additional, Chiarini, Giovanni, additional, Cattaneo, Sergio, additional, Puglia, Carmine, additional, Benussi, Stefano, additional, Foti, Giuseppe, additional, Giani, Marco, additional, Bombino, Michela, additional, Costa, Maria Cristina, additional, Rona, Roberto, additional, Avalli, Leonello, additional, Donati, Abele, additional, Carozza, Roberto, additional, Gasparri, Francesco, additional, Carsetti, Andrea, additional, Picichè, Marco, additional, Marinello, Anna, additional, Danzi, Vinicio, additional, Zanin, Anita, additional, Condello, Ignazio, additional, Fiore, Flavio, additional, Moscarelli, Marco, additional, Nasso, Giuseppe, additional, Speziale, Giuseppe, additional, Sandrelli, Luca, additional, Montalto, Andrea, additional, Musumeci, Francesco, additional, Circelli, Alessandro, additional, Russo, Emanuele, additional, Agnoletti, Vanni, additional, Rociola, Ruggero, additional, Milano, Aldo D, additional, Pilato, Emanuele, additional, Comentale, Giuseppe, additional, Montisci, Andrea, additional, Alessandri, Francesco, additional, Tosi, Antonella, additional, Pugliese, Francesco, additional, Giordano, Giovanni, additional, Carelli, Simone, additional, Grieco, Domenico L, additional, Dell'Anna, Antonio M, additional, Antonelli, Massimo, additional, Ramoni, Enrico, additional, Zulueta, Josè, additional, Del Giglio, Mauro, additional, Petracca, Sebastiano, additional, Bertini, Pietro, additional, Guarracino, Fabio, additional, De Simone, Luigi, additional, Angeletti, Paolo M, additional, Forfori, Francesco, additional, Taraschi, Francesco, additional, Quintiliani, Veronica N, additional, Samalavicius, Robertas, additional, Jankuviene, Agne, additional, Scupakova, Nadezda, additional, Urbonas, Karolis, additional, Kapturauskas, Juozas, additional, Soerensen, Gro, additional, Suwalski, Piotr, additional, Linhares Santos, Luis, additional, Marques, Ana, additional, Miranda, Marisa, additional, Teixeira, Sonia, additional, Salgueiro, Andrea, additional, Pereira, Filipe, additional, Ketskalo, Michail, additional, Tsarenko, Sergey, additional, Shilova, Alexandra, additional, Afukov, Ivan, additional, Popugaev, Konstantin, additional, Minin, Sergei, additional, Shelukhin, Daniil, additional, Malceva, Olga, additional, Gleb, Moroz, additional, Skopets, Alexander, additional, Kornelyuk, Roman, additional, Kulikov, Alexandr, additional, Okhrimchuk, Vadim, additional, Turchaninov, Alexandr, additional, Petrushin, Maxim, additional, Sheck, Anastasia, additional, Mekulov, Akhmed, additional, Ciryateva, Svetlana, additional, Urusov, Dmitry, additional, Gorjup, Vojka, additional, Golicnik, Alenka, additional, Goslar, Tomaz, additional, Ferrer, Ricard, additional, Martinez-Martinez, Maria, additional, Argudo, Eduard, additional, Palmer, Neiser, additional, De Pablo Sanchez, Raul, additional, Juan Higuera, Lucas, additional, Arnau Blasco, Lucas, additional, Marquez, Josè A, additional, Sbraga, Fabrizio, additional, Fuset, Mari Paz, additional, De Gopegui, Pablo Ruiz, additional, Claraco, Luis M, additional, De Ayala, Josè A, additional, Peiro, Maranta, additional, Ricart, Pilar, additional, Martinez, Sergio, additional, Chavez, Fernando, additional, Fabra, Marc, additional, Sandoval, elena, additional, Toapanta, David, additional, Carraminana, Albert, additional, Tellez, Adrian, additional, Ososio, Jeysson, additional, Milan, Pablo, additional, Rodriguez, Jorge, additional, Andoni, Garcia, additional, Gutierrez, Carola, additional, Perez de la Sota, Enrique, additional, Eixeres-Esteve, Andrea, additional, Garcia-Maellas, Maria Teresa, additional, Gutierrez-Gutierrez, Judit, additional, Arboleda-Salazar, Rafael, additional, Santa Teresa, Patricia, additional, Jaspe, Alexis, additional, Garrido, Alberto, additional, Castaneda, Galo, additional, Alcantara, Sara, additional, Martinez, Nuria, additional, Perez, Marina, additional, Villanueva, Hector, additional, Vidal Gonzalez, Anxela, additional, Paez, Juan, additional, Santon, Arnoldo, additional, Perez, Cesar, additional, Lopez, Marta, additional, Rubio Lopez, Maria Isabel, additional, Gordillo, Antonio, additional, Naranjo-Izurieta, Jose, additional, Munoz, Javier, additional, Alcalde, Immaculada, additional, Onieva, Fernando, additional, Gimeno Costa, Ricardo, additional, Perez, Francisco, additional, Madrid, Isabel, additional, Gordon, Monica, additional, Albacete Moreno, Carlos L, additional, Perez, Daniel, additional, Lopez, Nayara, additional, Martinenz, Domingo, additional, Blanco-Schweizer, Pablo, additional, Diez, Cristina, additional, Perez, David, additional, Prieto, Ana, additional, Renedo, Gloria, additional, Bustamante, Elena, additional, Cicuendez, Ramon, additional, Citores, Rafael, additional, Boado, Victoria, additional, Garcia, Katherine, additional, Voces, Roberto, additional, Domezain, Monica, additional, Nunez Martinez, Jose Maria, additional, Vicente, Raimundo, additional, Martin, David, additional, Andreu, Antonio, additional, Gomez Casal, Vanesa, additional, Chico, Ignacio, additional, Menor, Eva Maria, additional, Vara, Sabela, additional, Gamacho, Jose, additional, Perez-Chomon, Helen, additional, Javier Gonzales, Francisco, additional, Barrero, Irene, additional, Martin-Villen, Luis, additional, Fernandez, Esperanza, additional, Mendoza, Maria, additional, Navarro, Joaquin, additional, Colomina Climent, Joaquin, additional, Gonzales-Perez, Alfredo, additional, Muniz-Albaceita, Guillermo, additional, Amado, Laura, additional, Rodriguez, Raquel, additional, Ruiz, Emilio, additional, Eiras, Maria, additional, Grins, Edgars, additional, Magnus, Rosen, additional, Kanetoft, Mikael, additional, Eidevald, Marcus, additional, Watson, Pia, additional, Vogt, Paul R, additional, Steiger, Peter, additional, Aigner, Tobias, additional, Weber, Alberto, additional, Grunefelder, Jurg, additional, Kunz, Martin, additional, Grapow, Martin, additional, Aymard, Thierry, additional, Reser, Diana, additional, Agus, Gianluca, additional, Consiglio, Jolanda, additional, Haenggi, Matthias, additional, Hansjoerg, Jenni, additional, Iten, Manuela, additional, Doeble, Thomas, additional, Zenklusen, Urs, additional, Bechtold, Xavier, additional, Faedda, Giovanni, additional, Iafrate, Manuel, additional, Rohjer, Amanda, additional, Bergamaschi, Layla, additional, Maessen, Jos, additional, Reis Miranda, Dinis, additional, Endeman, H, additional, Gommers, D, additional, Meuwese, C, additional, Maas, Jacinta, additional, Van Gijlswijk, MJ, additional, Van Berg, RN, additional, Candura, Dario, additional, Van der Linden, Marcel, additional, Kant, Merijin, additional, Van der Heijden, JJ, additional, Scholten, Eric, additional, Van Belle-van Haren, Nicole, additional, Lagrand, WK, additional, Vlaar, Alexander P, additional, De Jong, Syste, additional, Cander, Basar, additional, Sargin, Murat, additional, Ugur, Murat, additional, Kaygin, Mehmet A, additional, Daly, Kathleen, additional, Agnew, Nicola, additional, Head, Laura, additional, Kelly, Laura, additional, Anoma, Gunawardena, additional, Russell, Clare, additional, Aquino, Verna, additional, Scott, Ian, additional, Flemming, Lucy, additional, Gillon, Stuart, additional, Moore, Olivia, additional, Gelandt, Elton, additional, Auzinger, George, additional, Patel, Sameer, additional, and Loveridge, Robert, additional

Published
2022
Full Text
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40. The ELSO Maastricht Treaty for ECLS Nomenclature: abbreviations for cannulation configuration in extracorporeal life support - a position paper of the Extracorporeal Life Support Organization

Author

Broman, Lars Mikael, Taccone, Fabio Silvio, Lorusso, Roberto, Malfertheiner, Maximilian Valentin, Pappalardo, Federico, Di Nardo, Matteo, Belliato, Mirko, Bembea, Melania M., Barbaro, Ryan P., Diaz, Rodrigo, Grazioli, Lorenzo, Pellegrino, Vincent, Mendonca, Malaika H., Brodie, Daniel, Fan, Eddy, Bartlett, Robert H., McMullan, Michael M., and Conrad, Steven A.

Published
2019
Full Text
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46. Cannulation Strategies in ECLS

Author

Broman, Lars Mikael, Swoi, Justyna, Haide, Maximilean, Donker, Dirk W., Cardiovascular and Respiratory Physiology, and TechMed Centre

Published
2022

47. Blood Pumps for Extracorporeal Membrane Oxygenation: Platelet Activation During Different Operating Conditions

Author

Fiusco, Francesco, Broman, Lars Mikael, and Prahl Wittberg, Lisa

Subjects
low flow, Infant, Newborn, Pediatric Circulatory Support, computational fluid dynamics, centrifugal pump, Platelet Activation, Hemolysis, Extracorporeal Membrane Oxygenation, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Hydrodynamics, Humans, backflow, Assisted Circulation, ECMO, thrombogenicity
Abstract

Supplemental Digital Content is available in the text., Extracorporeal membrane oxygenation (ECMO) is a therapy used in severe cardiopulmonary failure. Blood is pumped through an artificial circuit exposing it to nonphysiologic conditions, which promote platelet activation and coagulation. Centrifugal pumps used at lower flow rates than their design point may lose pump efficiency and increase the risk of hemolysis. In this study, thrombogenic properties of two ECMO pumps designed for adult and neonatal use were evaluated using simulations in different flow scenarios. Three scenarios, adult pump in adult mode (4 L/min), adult pump in baby mode (300 ml/min), and neonatal pump used in its design point (300 ml/min), were simulated using computational fluid dynamics. The flow was numerically seeded with platelets, whose activation state was computed considering the stress history that acted along their respective path lines. Statistical distributions of activation state and residence time were drawn. The results showed that using the adult pump in baby mode increased the fraction of platelets with higher activation state confirming that low-pump flow rate impacts thrombogenicity. The neonatal pump showed a backflow at the inlet, which carried platelets in a retrograde motion contributing to an increased thrombogenic potential compared with the adult mode scenario.

Published
2021

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